Clinical Oral Investigations最新文献

筛选
英文 中文
Three-unit posterior monolithic fixed dental prostheses made from high-translucent shade-graded zirconia: 3-Year results from a prospective clinical pilot study. 由高透光性锆石制成的三单元后部整体固定义齿:一项前瞻性临床试验研究的三年结果。
IF 3.1 2区 医学
Clinical Oral Investigations Pub Date : 2024-12-16 DOI: 10.1007/s00784-024-06084-5
Jan-Frederik Güth, Christine Keul, Anja Liebermann, Josef Schweiger, Daniel Edelhoff, Oliver Schubert
{"title":"Three-unit posterior monolithic fixed dental prostheses made from high-translucent shade-graded zirconia: 3-Year results from a prospective clinical pilot study.","authors":"Jan-Frederik Güth, Christine Keul, Anja Liebermann, Josef Schweiger, Daniel Edelhoff, Oliver Schubert","doi":"10.1007/s00784-024-06084-5","DOIUrl":"https://doi.org/10.1007/s00784-024-06084-5","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the clinical performance of tooth-supported 3-unit fixed dental prostheses (FDPs) made from shade-graded monolithic 5Y-PSZ (partly stabilized zirconia) zirconia in terms of survival rate and the quality of restorations based on modified FDI criteria over three-years.</p><p><strong>Materials and methods: </strong>High-translucent shade-graded monolithic zirconia (Lava Esthetic, Solventum Dental Solutions) was used to manufacture maxillary or mandibular three-unit FDPs in the posterior region (N = 22) employing subtractive milling system (Amann Girrbach). All FDPs were bonded with a universal resin cement (Rely X Universal, Solventum Dental Solutions) and evaluated 4 weeks after cementation (baseline) and after 1, 2, and 3 years. The primary objective was to assess the survival and complication rates of the restorations. Furthermore, the quality of the restorations was evaluated based on selected and modified FDI (World Dental Federation) criteria, which encompass functional, aesthetic, and biological parameters. FDI criteria were analyzed using the Fisher-Freeman-Halton exact test.</p><p><strong>Results: </strong>Twenty-one patients were examined at 1 year, 2 years, and 3 years. The survival rate was 100%. No mechanical complications were observed. A total of 3 biological complications occurred. These were successfully managed without any residual functional impairment. All FDI criteria were found to be clinically acceptable or better.</p><p><strong>Conclusions: </strong>Monolithic shade-graded zirconia FDPs demonstrated 100% survival at 3 years with a low complication rate.</p><p><strong>Clinical relevance: </strong>Fixed 3-unit FDPs made of high-translucent monolithic zirconia might be a viable treatment option in the posterior region, preventing the chipping phenomenon and providing favorable aesthetics while allowing for an efficient digital workflow.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"17"},"PeriodicalIF":3.1,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142834086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Accuracy of digital jaw relation determination in different occlusal conditions - an in vitro study. 不同咬合条件下数字颌骨关系测定的准确性 - 一项体外研究。
IF 3.1 2区 医学
Clinical Oral Investigations Pub Date : 2024-12-14 DOI: 10.1007/s00784-024-06101-7
Daniel Hellmann, Felix M Knoch, Stefan Repky, Fatih Kilic, Bernd G Lapatki, Johanna Radeke
{"title":"Accuracy of digital jaw relation determination in different occlusal conditions - an in vitro study.","authors":"Daniel Hellmann, Felix M Knoch, Stefan Repky, Fatih Kilic, Bernd G Lapatki, Johanna Radeke","doi":"10.1007/s00784-024-06101-7","DOIUrl":"https://doi.org/10.1007/s00784-024-06101-7","url":null,"abstract":"<p><strong>Objectives: </strong>In orthodontics, accurate registration of jaw relationships is essential for correct diagnosis and treatment planning. Therefore, accuracy of the digital spatial registration of maxillary and mandibular models and - for the first time-the influence of dentition stage and malocclusion type on this procedure were investigated under controlled conditions.</p><p><strong>Materials and methods: </strong>Eight pairs of jaw models, representing different occlusal and developmental statuses (m1-m8), were scanned using two IOS types (PS: Primescan; TR: Trios4). Buccal scans for registering maxillary and mandibular models were repeated (n = 3). Reference scans were obtained using a desktop scanner (RDS; Ceramill Map 600). Arch-specific 3D coordinate systems were used to calculate the linear and angular deviations among different registrations. Trueness of registration by PS and TR was calculated using a statistical mixed-effect model (random-effect: model-type). Precision values of IOS registrations across m1-m8 were characterized as standard deviations (SDs).</p><p><strong>Results: </strong>As maximum deviations compared to RDS, PS showed caudal translation (0.11 ± 0.02 mm), while TR showed ventral translation (0.08 ± 0.06 mm), of the maxillary relative to the mandibular model. Maximum rotational values were calculated for tilting around the transverse axis (PS: anteinclination (0.25 ± 0.16°), TR: retroinclination (0.27 ± 0.16°)). These deviations varied with the malocclusion type. The lowest IOS precision was recorded for sagittal translation (PS: 0.013 ± 0.005 mm, TR: 0.021 ± 0.010 mm) and rotation around the transverse axis (PS: 0.051 ± 0.013°, TR: 0.076 ± 0.031°).</p><p><strong>Conclusions and clinical relevance: </strong>Registrations using buccal IOS scans showed quantifiable but clinically negligible 3D deviations from reference scan registrations, whereby the type of tooth and jaw misalignment did not appear to have a clinically relevant influence. Therefore, the examined IOSs appear to be suitable for digital jaw relation determination in everyday clinical orthodontic practice.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"16"},"PeriodicalIF":3.1,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142823785","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Application of dynamic navigation technology in oral and maxillofacial surgery.
IF 3.1 2区 医学
Clinical Oral Investigations Pub Date : 2024-12-13 DOI: 10.1007/s00784-024-06098-z
Fushi Wang, Xinjie Cai, Wei Sun, Chen Chen, Liuyan Meng
{"title":"Application of dynamic navigation technology in oral and maxillofacial surgery.","authors":"Fushi Wang, Xinjie Cai, Wei Sun, Chen Chen, Liuyan Meng","doi":"10.1007/s00784-024-06098-z","DOIUrl":"https://doi.org/10.1007/s00784-024-06098-z","url":null,"abstract":"<p><strong>Objectives: </strong>Dynamic navigation (DN) technology has ushered in a paradigm shift in dentistry, revolutionizing the precision of diverse procedures in oral and craniofacial surgery. This comprehensive review aims to review the manifold applications of DN, including implantology, endodontics, oral and dental surgeries, and other dental disciplines.</p><p><strong>Materials and methods: </strong>A thorough search of the online databases PubMed and Google Scholar was conducted up to March 2024. Publications associated with DN in the field of oral and maxillofacial surgery were sourced.</p><p><strong>Results: </strong>Narrative literature review.</p><p><strong>Conclusions: </strong>DN harnesses cone beam computerized tomography imaging, virtual design software, and motion tracking technology to construct a virtual model of the patient's oral cavity, affording real-time instrument tracking during procedures. Notably, in implantology, DN facilitates implant placement, enhances safety measures, and augments procedural efficiency. The application of DN in sinus lift procedures contributes to improved surgical outcomes and reduced complications. Within endodontics, DN guides root canal treatment (RCT), retreatment of failed RCT, and endodontic microsurgery, ensuring conservative access cavities and precise canal location. Beyond these, the versatility of DN extends to encompass maxillomandibular and orthognathic surgeries, tooth extraction, removal of foreign bodies, and facial reconstruction. However, it is crucial to acknowledge potential disadvantages and error-prone scenarios as DN technologies advance.</p><p><strong>Clinical significance: </strong>DN technology empowers dentists with high accuracy, heightened safety protocols, and increased procedural efficiency, culminating in enhanced patient outcomes across various dental procedures. As DN technology further expands, its pivotal role will advance in the future of oral and maxillofacial surgery.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"13"},"PeriodicalIF":3.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817449","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Early orthodontic treatment need over a 10-year period and evaluation of short-term intervention stability.
IF 3.1 2区 医学
Clinical Oral Investigations Pub Date : 2024-12-13 DOI: 10.1007/s00784-024-06104-4
Maike Tabellion, Ines Caroline Loef, Constanze Charlotte Linsenmann, Jörg Alexander Lisson
{"title":"Early orthodontic treatment need over a 10-year period and evaluation of short-term intervention stability.","authors":"Maike Tabellion, Ines Caroline Loef, Constanze Charlotte Linsenmann, Jörg Alexander Lisson","doi":"10.1007/s00784-024-06104-4","DOIUrl":"10.1007/s00784-024-06104-4","url":null,"abstract":"<p><strong>Objective: </strong>Early orthodontic treatment with cost reimbursement within the framework of the German statutory health insurance (GKV) is only possible for a strictly defined malocclusion group as defined by the orthodontic indication groups (KIG). It is not yet clear whether the application of the KIG criteria and corresponding successful early orthodontic interventions result in no or significantly less need for treatment in the late mixed dentition or in the permanent dentition. This study therefore investigated short-term intervention stability from a 10-year-period.</p><p><strong>Materials and methods: </strong>Between 2009 and 2019, n = 661 patients were diagnosed with indication groups D (increased overjet), M (reversed overjet), B (scissors bite), K (crossbite), or P (lack of space) including orthodontic treatment need. N = 70 patients (35 female, 35 male) met the inclusion criteria of the study and had received early orthodontic treatment with a mean duration of 15.44 ± 2.20 months. Orthodontic indication groups (KIG) were evaluated at the beginning (aged 7.99 ± 1.44 years) and the end of early orthodontic treatment (aged 9.63 ± 1.49 years) and at a voluntary control or the beginning of additional orthodontic treatment (aged 11.85 ± 1.72 years). The evaluation included established procedures for categorization of orthodontic indication groups and their respective classification. Statistics included Chi-square test and Kendall´s tau-b. The level of significance was set at p < 0.05.</p><p><strong>Results: </strong>The results showed reversed overjet in 44.3% and crossbites in 41.4% of the patients as most common indication for early orthodontic treatment. At the end of early orthodontic treatment, no orthodontic treatment need was present in 87.1%. At the late mixed dentition, the treatment result of early orthodontic treatment was stable in N = 61 out of N = 70 patients.</p><p><strong>Conclusions: </strong>The results of our study confirm preventive benefits of early orthodontic treatment, especially in patients with transverse anomalies or reversed overjet.</p><p><strong>Clinical relevance: </strong>A short-term orthodontic intervention with correct indication during primary or early mixed dentition can prevent or reduce further treatment need during late mixed or permanent dentition, and should therefore not be postponed.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"12"},"PeriodicalIF":3.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11638389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impaired salivary gland function in children with osteogenesis imperfecta: a case-control study.
IF 3.1 2区 医学
Clinical Oral Investigations Pub Date : 2024-12-13 DOI: 10.1007/s00784-024-06100-8
Patrizia Defabianis, Rossella Ninivaggi, Norma Bocca, Luisa De Sanctis, Daniele Tessaris, Federica Romano
{"title":"Impaired salivary gland function in children with osteogenesis imperfecta: a case-control study.","authors":"Patrizia Defabianis, Rossella Ninivaggi, Norma Bocca, Luisa De Sanctis, Daniele Tessaris, Federica Romano","doi":"10.1007/s00784-024-06100-8","DOIUrl":"https://doi.org/10.1007/s00784-024-06100-8","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the present study was to evaluate salivary gland function and oral health status in Osteogenesis imperfecta (OI) children, comparing to a control group, and to investigate the possible influence of bisphosphonate (BP) treatment.</p><p><strong>Materials and methods: </strong>Patients aged 8-15 years with any OI molecularly confirmed and gender-matched healthy control were consecutively recruited at the Section of Pediatric Dentistry (Dental School-University of Turin). Comprehensive dental examinations were conducted to evaluate carious lesions, plaque and gingival index, stimulated saliva flow rate, pH, and buffer capacity.</p><p><strong>Results: </strong>A total al of 22 OI patients (mean age: 10.7 ± 2.4 years) and 22 age- and gender-matched healthy controls (mean age: 10.3 ± 2.3 years) were consecutively enrolled. In OI patients reduced saliva quality and quantity and poor oral health, were observed compared to healthy peers. OI subjects exhibited significantly lower stimulated salivary flow rates (SFR; P < 0.001), higher gingival inflammatory status (P = 0.003) and carious experience in both the deciduous (P = 0.038) and permanent dentition (P = 0.005) Stratifying data based on BP assumption, statistically significant differences in resting (P = 0.024) and stimulated SFR (P = 0.019) were observed as compared to OI subjects not using BP drugs.</p><p><strong>Conclusions: </strong>Pediatric OI patients show reduced SFR and poor oral health, highlighting the need for regular screenings and early salivary management.</p><p><strong>Clinical relevance: </strong>Impairment of salivary gland function is suggested by these preliminary data in pediatric patients with OI.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"14"},"PeriodicalIF":3.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817468","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Prospective clinical study of enamel wear caused by monolithic zirconia resin-bonded inlay-retained and wing-retained fixed partial dentures over 5 years.
IF 3.1 2区 医学
Clinical Oral Investigations Pub Date : 2024-12-13 DOI: 10.1007/s00784-024-06103-5
Wolfgang Bömicke, Julius Haas, Sinclair Awounvo, Peter Rammelsberg, Stefan Rues
{"title":"Prospective clinical study of enamel wear caused by monolithic zirconia resin-bonded inlay-retained and wing-retained fixed partial dentures over 5 years.","authors":"Wolfgang Bömicke, Julius Haas, Sinclair Awounvo, Peter Rammelsberg, Stefan Rues","doi":"10.1007/s00784-024-06103-5","DOIUrl":"10.1007/s00784-024-06103-5","url":null,"abstract":"<p><strong>Objectives: </strong>To prospectively evaluate the wear of posterior zirconia resin-bonded fixed partial dentures (RBFPDs) with polished occlusal surfaces and their natural enamel antagonists compared to contralateral controls in an enamel-enamel contact over 5 years.</p><p><strong>Materials and methods: </strong>In six patients with either an inlay- or wing-retained RBFPD made of monolithic 3 mol% yttria-stabilized tetragonal zirconia polycrystal (3Y-TZP), wear was evaluated indirectly using baseline and annual polyvinyl siloxane impressions. Resulting gypsum models were digitized and aligned by unchanged surface areas. Wear was analyzed by depth and area. For each parameter, descriptive statistics were used to express the degree of wear observed at yearly intervals for each group. A linear mixed regression analysis was performed to compare the enamel opposing 3Y-TZP group and the enamel-enamel controls at tooth level. All statistical tests were conducted at the 5% significance level.</p><p><strong>Results: </strong>After 5 years, the mean enamel wear depth of teeth opposing 3Y-TZP was 77 μm, compared to 54 μm for control teeth. No wear was observed on the 3Y-TZP RBFPDs. Maximum enamel wear depth and wear area were 229 μm and 9 mm², respectively, for teeth opposing 3Y-TZP, and 135 μm and 5 mm² for control teeth. Significant differences in mean enamel wear depth emerged after 2 years of observation.</p><p><strong>Conclusions: </strong>Polished 3Y-TZP caused more enamel wear than natural antagonists over 5 years, but the wear remained within the range reported for other commonly used indirect restorative materials.</p><p><strong>Clinical relevance: </strong>The clinical use of polished 3Y-TZP restorations appears to be justified in terms of natural antagonist wear behavior.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"15"},"PeriodicalIF":3.1,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11645306/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821919","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
A pilot study of the relationship between salivary microbial characteristics and endocrine and immune function in patients with burning mouth syndrome.
IF 3.1 2区 医学
Clinical Oral Investigations Pub Date : 2024-12-12 DOI: 10.1007/s00784-024-06102-6
Qianqian Zhang, Xinghan Li, Zhiyi Wang, Shijiao Shen, Junzhe Wang, Junyang Chen, Xiaoran Shi, Shichen Wang, Jun Cao, Yongqiang Deng, He Meng, Lin Ma
{"title":"A pilot study of the relationship between salivary microbial characteristics and endocrine and immune function in patients with burning mouth syndrome.","authors":"Qianqian Zhang, Xinghan Li, Zhiyi Wang, Shijiao Shen, Junzhe Wang, Junyang Chen, Xiaoran Shi, Shichen Wang, Jun Cao, Yongqiang Deng, He Meng, Lin Ma","doi":"10.1007/s00784-024-06102-6","DOIUrl":"https://doi.org/10.1007/s00784-024-06102-6","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the potential role of oral bacteria in the pathogenesis of burning mouth syndrome (BMS).</p><p><strong>Materials and methods: </strong>Fifteen patients with BMS and 15 healthy controls were enrolled in this study. The relative abundance and diversity of salivary bacterial strains were analyzed using metagenomic DNA sequencing. The functionality of non-redundant genes was obtained by comparing the mmseqs2 with the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. BMS relating salivary protein markers were detected using enzyme-linked immunosorbent assay (ELISA).</p><p><strong>Results: </strong>Partial least-squares discriminant analysis (PLS-DA) revealed that the salivary bacterial profiles of the BMS group (mean age: 38.9 ± 2.2 years) differed significantly from those of the control group (mean age: 34.1 ± 2.3 years) in terms of the abundance of dominant phyla, classes, orders, families, genera and species. Functional analysis revealed distinct endocrine and immune functions in the BMS group. The salivary cortisol and α-amylase levels were significantly higher, and salivary interleukn-6 levels were significantly lower in the BMS group than in the control group. Species contribution analysis of endocrine and immune functions revealed that Streptococcus mitis was an important contributor to endocrine and immune functions in the BMS group.</p><p><strong>Conclusions: </strong>Salivary dysbiosis related to endocrine and immune functions may be a possible cause of BMS.</p><p><strong>Clinical relevance: </strong>These findings could assist in the diagnosis and therapy of BMS.</p><p><strong>Clinical trial number: </strong>Not applicable.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"11"},"PeriodicalIF":3.1,"publicationDate":"2024-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142812429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Main genetic entities associated with tooth agenesis.
IF 3.1 2区 医学
Clinical Oral Investigations Pub Date : 2024-12-11 DOI: 10.1007/s00784-024-05941-7
Francisco Cammarata-Scalisi, Colin E Willoughby, Jinia R El-Feghaly, Antonio Cárdenas Tadich, Maykol Araya Castillo, Shadi Alkhatib, Marwa Abd Elsalam Elsherif, Rabab K El-Ghandour, Riccardo Coletta, Antonino Morabito, Michele Callea
{"title":"Main genetic entities associated with tooth agenesis.","authors":"Francisco Cammarata-Scalisi, Colin E Willoughby, Jinia R El-Feghaly, Antonio Cárdenas Tadich, Maykol Araya Castillo, Shadi Alkhatib, Marwa Abd Elsalam Elsherif, Rabab K El-Ghandour, Riccardo Coletta, Antonino Morabito, Michele Callea","doi":"10.1007/s00784-024-05941-7","DOIUrl":"https://doi.org/10.1007/s00784-024-05941-7","url":null,"abstract":"<p><strong>Background: </strong>Tooth agenesis refers to the absence of one or more of the deciduous or permanent teeth. Tooth agenesis results from a series of disrupted reciprocal ectodermal mesenchymal interactions taking place during the early stages of tooth development.</p><p><strong>Methods: </strong>A narrative literature review was performed to describe the main genetic syndromes associated with tooth agenesis.</p><p><strong>Results and conclusions: </strong>The etiology of congenital tooth agenesis is multifactorial and include genetic, epigenetic, and environmental influences. Syndromes associated with chromosomal alterations, ectodermal dysplasia, Axenfeld-Rieger syndrome, oral-facial cleft syndromes, and syndromes with cancer predisposition are among the main entities presenting with tooth agenesis.</p><p><strong>Clinical relevance: </strong>Tooth agenesis disorders can affect the masticatory function and cause disfigurement leading to physiological and psychological complications. Early recognition of these entities is crucial to guide the management of the patient and to provide families with the appropriate genetic counseling.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"9"},"PeriodicalIF":3.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic potential of farnesoid X receptor agonists for modulating inflammation and periodontal regeneration.
IF 3.1 2区 医学
Clinical Oral Investigations Pub Date : 2024-12-11 DOI: 10.1007/s00784-024-06087-2
Jie Huang, Huang Zhang, Xusheng Fan, Yongwu Wang
{"title":"Therapeutic potential of farnesoid X receptor agonists for modulating inflammation and periodontal regeneration.","authors":"Jie Huang, Huang Zhang, Xusheng Fan, Yongwu Wang","doi":"10.1007/s00784-024-06087-2","DOIUrl":"https://doi.org/10.1007/s00784-024-06087-2","url":null,"abstract":"<p><strong>Objectives: </strong>Inflammation and osteoclast activity are important in various diseases, including periodontitis and osteoporosis. Farnesoid X receptor (FXR) has been identified as a promising target for modulating these processes. This study delved into the impact of FXR agonists on inflammation and periodontal regeneration using periodontitis models.</p><p><strong>Material and methods: </strong>The RAW264.7 and gingival fibroblast cells were divided into five groups: control, lipopolysaccharide (LPS), LPS combined with FXR agonist, LPS with si-FXR, and LPS with si-FXR alongside FXR agonist. FXR expression and pro-inflammatory cytokine levels were quantified. Osteoclast activity was evaluated by observing morphological alterations and tartrate-resistant acid phosphatase staining. The rats were used to establish periodontitis models and received varying doses of FXR agonist. Bone health metrics were assessed, and the expressions of runt-related transcription factor 2 (RUNX2), integrin-binding sialoprotein (IBSP), nuclear factor-kappa B (NF-kB), phosphorylated nuclear factor-kappa B (p-NF-kB), toll-like receptor 4 (TLR4), and toll-like receptor 2 (TLR2) were determined.</p><p><strong>Results: </strong>FXR suppressed the release of pro-inflammatory cytokines in both LPS-stimulated RAW264.7 and gingival fibroblast cells, while curbing osteoclastogenesis. In periodontitis rat models, FXR agonist administration caused notable enhancement in bone density. Moreover, FXR agonist mitigated periodontal inflammation, decreased periodontal index markers and suppressed the expressions of NF-kB, p-NF-kB, TLR4, and TLR2, but upregulated the expressions of RUNX2 and IBSP.</p><p><strong>Conclusion: </strong>The data underscores the potential of FXR agonists in attenuating inflammation and periodontal regeneration, both in vitro and in vivo. This suggests the potential therapeutic application of FXR agonists in conditions marked by inflammation and bone degradation.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"10"},"PeriodicalIF":3.1,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142806353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oral biofluid levels of Activin-A and interleukin-1beta in stage III periodontitis. III 期牙周炎患者口腔生物流体中的活化素-A 和白细胞介素-1beta 水平。
IF 3.1 2区 医学
Clinical Oral Investigations Pub Date : 2024-12-10 DOI: 10.1007/s00784-024-06088-1
Can Özden, Beral Afacan, Harika Atmaca İlhan, Timur Köse, Gülnur Emingil
{"title":"Oral biofluid levels of Activin-A and interleukin-1beta in stage III periodontitis.","authors":"Can Özden, Beral Afacan, Harika Atmaca İlhan, Timur Köse, Gülnur Emingil","doi":"10.1007/s00784-024-06088-1","DOIUrl":"https://doi.org/10.1007/s00784-024-06088-1","url":null,"abstract":"<p><strong>Objectives: </strong>Activin-A belongs to the transforming growth factor-beta superfamily and is a multifunctional cytokine that plays a role in inflammation, immune response, tissue repair and regeneration. Proinflammatory cytokine interleukin-1beta (IL-1β) can increase Activin-A expression in various cell types. This study aims to evaluate gingival crevicular fluid (GCF) and salivary Activin-A and IL-β levels in stage III periodontitis.</p><p><strong>Materials and methods: </strong>23 patients with stage III periodontitis, 26 with gingivitis and 26 periodontally healthy individuals were included. Full-mouth clinical periodontal indices were recorded, unstimulated whole saliva and GCF samples were obtained, Activin-A and IL-1β total amounts were determined by ELISA. Statistical comparisons were performed using non-parametric tests. Receiver operating characteristics curve was used for estimating the area under the curve (AUC).</p><p><strong>Results: </strong>Periodontitis group exhibited significantly lower GCF Activin-A levels but higher IL-1β levels than the periodontally healthy group (p < 0.05). Gingivitis group had similar GCF Activin-A and IL-1β levels to the periodontitis and periodontally healthy groups (p > 0.05). Salivary Activin-A and IL-1β concentrations were similar among study groups (p > 0.05). GCF Activin-A level showed an excellent diagnostic performance (an AUC value of 0.82 with 87% sensitivity) to discriminate periodontitis from periodontal health.</p><p><strong>Conclusions: </strong>For the first time, this study demonstrated oral biofluid levels of Activin-A in periodontal health and diseases. Within the limits of the study, it might be suggested that diseased sites in periodontitis are associated with reduced Activin-A and increased IL-1β levels in GCF.</p><p><strong>Clinical relevance: </strong>Reduced GCF Activin-A levels and the accompanying increase in IL-1β might be associated with diseased sites in stage III periodontitis.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"7"},"PeriodicalIF":3.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
相关产品
×
本文献相关产品
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信