{"title":"Platelet-rich fibrin application after mandibular third molar extraction: an umbrella review.","authors":"Hao Yang, Jinghong Yu, Dongxue Wu","doi":"10.1007/s00784-024-06119-x","DOIUrl":"10.1007/s00784-024-06119-x","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was evaluate the effect of Platelet-Rich Fibrin (PRF) in patients after mandibular third molar extraction through an analysis of the most current literature on systematic reviews and meta-analyses.</p><p><strong>Data, sources and study selection: </strong>By using computer-assisted search technology, we comprehensively searched several reliable databases, such as China National Knowledge Infrastructure (CNKI), WanFang Data, the Chinese biomedical literature database, PubMed, Web of Science, EMBase, and the Cochrane Library, and performed a systematic retrospective meta-analysis on all of the collected studies on the therapeutic effects of PRF on patients after mandibular third molar extraction. A total of nine meta-analyses were performed in this study, and all nine studies were rated as high quality on the basis of the AMSTAR 2 criteria. Seven outcome indicators were extracted from the nine meta-analyses.</p><p><strong>Conclusion: </strong>According to the included studies, which all demonstrated high scientific quality, PRF application after mandibular third molar extraction significantly reduces postoperative pain and inflammation, accelerates soft tissue healing, and effectively lowers the incidence of complications such as dry socket and alveolar osteitis. However, PRF did not significantly affect trismus or bone density. The conclusion has reliable support and clinical significance.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"34"},"PeriodicalIF":3.1,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Clinical evaluation of single bond universal adhesive in non-carious cervical lesions: a 36-month retrospective study.","authors":"Hatice Tepe, Ozge Celiksoz, Batu Can Yaman","doi":"10.1007/s00784-024-06126-y","DOIUrl":"10.1007/s00784-024-06126-y","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the 36-month clinical performance of Single Bond Universal Adhesive (SBU; 3M ESPE, Germany) in non-carious cervical lesions (NCCLs) using different modes of adhesion according to the FDI criteria. The primary outcome was the retention loss of the restorations, while the secondary outcomes included marginal staining, marginal adaptation, post-operative sensitivity and tooth vitality, recurrence of caries erosion and abfraction, and tooth integrity, all evaluated according to the FDI criteria.</p><p><strong>Materials and methods: </strong>In this study, the SBU Adhesive was applied to 246 NCCLs of 25 patients using different modes of adhesion: Self-etch (SE), selective-enamel-etching (SLE), and etch-and-rinse (ER). All lesions were restored with the same nanohybrid resin composite. The restorations were evaluated at the 1st, the 6th, 12th, 18th, and 36th month using the FDI criteria. The differences between SE, SLE, and ER groups were tested using the Kruskal-Wallis and Mann-Whitney U tests where a value of p < 0.05 was accepted as a criterion for statistical significance.</p><p><strong>Results: </strong>After 36-month the recall rate was 96%. The retention loss rates were 29.33% for SE, 16.66% for SLE, and 3.89% for ER modes. Interactions between time periods and adhesive modes were found to be statistically significant (p < 0.05) for all FDI criteria. ER mode performed significantly better than SE mode for marginal staining, marginal adaptation and recurrence of caries, erosion and abfraction criteria after the 36th month (p < 0.05). There was no statistically significant difference between SE and SLE mode (p > 0.05), nor between SLE and ER mode (p > 0.05).</p><p><strong>Conclusions: </strong>After the 36-month evaluation of all adhesive modes used in the study, restorations performed with the ER adhesion mode were clinically good (2), while those performed with the SE adhesion mode and SLE adhesion mode were clinically satisfactory (3) according to the FDI criteria. The primary outcome, retention loss, was significantly lower in the ER mode compared to SE and SLE modes. For secondary outcomes, the ER mode showed better performance in marginal staining, marginal adaptation, and the recurrence of caries, erosion, and abfraction highlighting its clinical advantages for mid-term success in non-carious cervical lesions.</p><p><strong>Clinical relevance: </strong>Restorations performed with the SE adhesion mode of universal adhesives exhibit clinically acceptable behavior after 36 months of evaluation, although with less success than those performed with the ER adhesion mode.</p><p><strong>Clinical trial registration: </strong>Clinical trials number- NCT06227715, Clinical trials link: https://clinicaltrials.gov/study/NCT06227715.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"33"},"PeriodicalIF":3.1,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892620","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Daniele Moreira Cavalcante, Sandro J O Tavares, Luiz Otávio Purger, Pantaleo Scelza, Marco Antonio Gallito, Aline Saddock, Ricardo Tadeu Lopes, Miriam F Zaccaro Scelza
{"title":"Vertical root fractures and cracked teeth: post-endodontic root dentinal status through micro-CT assessment after ex vivo fiber post removal.","authors":"Daniele Moreira Cavalcante, Sandro J O Tavares, Luiz Otávio Purger, Pantaleo Scelza, Marco Antonio Gallito, Aline Saddock, Ricardo Tadeu Lopes, Miriam F Zaccaro Scelza","doi":"10.1007/s00784-024-06116-0","DOIUrl":"10.1007/s00784-024-06116-0","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate cracked teeth and vertical root fracture observable on micro-CT images of extracted roots of mandibular incisors, after fiber post removal.</p><p><strong>Materials and methods: </strong>Thirty mandibular incisors were selected with any degree of slight incisal wear inspected with the aid of a stereomicroscope under 12x magnification, in order to have a group of young adult specimens according to the criteria of Hugoson et al. A sample of twelve mandibular incisors were selected, aged between 20 and 30 years old, with similar dentine volume and thickness. The specimens were scanned in a micro-computed tomography (micro-CT) device and submitted to root canal shaping, root canal filling, post space preparation, post placement and post removal.</p><p><strong>Results: </strong>From a total of six experimental endodontic timepoints until post removal of 12 mandibular incisors, 64,800 cross-sectional images were analyzed and no vertical root fracture (VRF) or cracked tooth were detected.</p><p><strong>Conclusions: </strong>Micro-CT assessment after ex vivo fiber post removal did not detect vertical root fracture or cracked tooth formation in the root canal walls of mandibular incisors.</p><p><strong>Clinical relevance: </strong>This study highlighted that fiber post removal per se was not able to propagate VRF or cracked tooth formation or promoted any interruption of the integrity of human root dentin.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"32"},"PeriodicalIF":3.1,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892609","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A comparative study of Twin-Block and van Beek Headgear-Activator on the three-dimensional morphology of the upper airway in growing children with mandibular retraction in skeletal class II malocclusion.","authors":"Huilin Li, Danfeng Li, Liping Liu, Tian Yang, Yuqian Li, Jiali Tan","doi":"10.1007/s00784-024-06066-7","DOIUrl":"10.1007/s00784-024-06066-7","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the variations in the upper airway of children with skeletal Class II mandibular retrognathism treated with van Beek Headgear-Activator (vBHGA) and Twin-Block (TB) appliances.</p><p><strong>Materials and methods: </strong>40 children were involved in this retrospective study and divided into two intervention groups: the vBHGA group and the TB group, each comprising 20 individuals with an average age of 11.13 years. Employing Cone Beam Computed Tomography and Geometric Morphometric analysis, a comprehensive assessment of the upper airway's volume, minimum cross-sectional area (m-CSA), and 3D shape characteristics was conducted pre-and post-treatment.</p><p><strong>Results: </strong>The total volume, oropharynx volume, oropharynx m-CSA, and hypopharynx m-CSA significantly increased in both the vBHGA and TB groups (p < 0.05). The sole discrepancy between the two groups was observed in comparing the nasopharynx m-CSA (p < 0.05). A morphological difference was observed in the vBHGA group before and after treatment (p < 0.05), characterized by a wider and shorter airway, positioning of the posterior nasal spine closer to the anterior inferior area, and a more posterior nasopharyngeal wall. However, there were no significant shape differences between the two groups or before and after treatment within the TB group.</p><p><strong>Conclusion: </strong>It appears that both vBHGA and TB interventions contribute positively to alleviating upper airway constriction. Nonetheless, the vBHGA group exhibits more alterations in the configuration of the nasopharynx.</p><p><strong>Clinical relevance: </strong>Both orthodontic appliances have a positive impact on the upper airway but still have differences, emphasizing the need for individualized consideration when selecting orthodontic interventions.</p><p><strong>Clinical trial registration: </strong>This study was also registered with the Chinese Clinical Trial Registry with registration number ChiCTR2400086867.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"31"},"PeriodicalIF":3.1,"publicationDate":"2024-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jonathan Creeth, Gary Smith, Billy Franks, Anderson Hara, Domenick Zero
{"title":"Remineralisation of enamel erosive lesions by daily-use fluoride treatments: network meta-analysis of an in situ study set.","authors":"Jonathan Creeth, Gary Smith, Billy Franks, Anderson Hara, Domenick Zero","doi":"10.1007/s00784-024-06107-1","DOIUrl":"10.1007/s00784-024-06107-1","url":null,"abstract":"<p><strong>Objectives: </strong>Daily-use fluoride products are first-line protection against enamel wear from dietary-acid exposure (DAE). This study aimed to understand effects of fluoride concentration, fluoride salt, product form and ingredients in daily-use products on remineralisation and demineralisation, via network meta-analysis (NMA) of 14 studies using one well-established in-situ model. Remineralisation (surface-microhardness recovery, SHMR) after treatment, and protection against subsequent demineralisation (acid-resistance ratio, ARR) were measured.</p><p><strong>Materials and methods: </strong>Healthy participants, wearing intra-oral palatal appliances holding enamel specimens eroded with standardised DAE, used test products once. Enamel hardness was assessed (Knoop microhardness probe) pre-DAE; post-DAE; after 4 h intra-oral remineralisation; and after post-remineralisation DAE. NMA was performed using a mixed-models approach on subject-level data to estimate and compare means.</p><p><strong>Results: </strong>There was a dose-response for fluoride ion in toothpastes (0-1426ppm F; p < 0.001 for SMHR and ARR). One toothpaste (silica-based, 1150ppm F as NaF) showed a benefit for SMHR versus placebo [mean(standard error)]: 8.8%(0.6%) (33.0% vs. 24.2%; p < 0.001); for ARR: 0.27(0.03) (0.43 vs. 0.15; p < 0.001; 9 mutual studies). Use of fluoride mouthwash after fluoride toothpaste increased SMHR [2.4%(1.1%); p = 0.043; 3 studies]; the effect on ARR [0.08(0.05)] was not significant (p = 0.164). Negative effects of polyvalent metal ions and polyphosphates on SMHR (p < 0.05) were observed.</p><p><strong>Conclusions: </strong>NMA proved effective in discriminating between fluoride-based treatments in this in-situ study, highlighting the importance of fluoride ion to enamel protection and showing formulation ingredients can affect its performance.</p><p><strong>Clinical relevance: </strong>Daily-use fluoride products can protect enamel against dietary acids, but careful formulation is required for optimal performance.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"28"},"PeriodicalIF":3.1,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11671545/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892606","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Comparative analysis of the effect of self-assembling peptide P<sub>11</sub>-4 on enamel erosion: a confocal laser scanning microscopy study.","authors":"Buse Yilmaz Sen, Merve Akcay","doi":"10.1007/s00784-024-06115-1","DOIUrl":"10.1007/s00784-024-06115-1","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to comparatively assess the preventive and protective effects of the self-assembling peptide P<sub>11</sub>-4 on enamel erosion and evaluate the potential for enamel surface recovery when professional products are combined with home-use dental-care products during the erosive process.</p><p><strong>Materials and methods: </strong>Ninety-nine bovine incisors were divided into nine groups: a control group, four groups with the application of professional-products [P<sub>11</sub>-4 peptide (Curodont-Repair), stannous/Sn<sup>2+</sup> containing solution (8% Sn<sup>2+</sup>), casein-phosphopeptide-amorphous-calcium-phosphate fluoride/CPP-ACPF (MI Varnish), sodium fluoride/NaF (Profluorid)] and four groups with the combination of professional products and home-use daily dental care products [P<sub>11</sub>-4 peptide (Curodont Repair + Curodont Protect), stannous ions containing agents (8% Sn<sup>2+</sup>+Emofluor Gel Intensive-Care), CPP-ACPF (MI Varnish + MI Paste Plus), NaF (Profluorid + ReminPro)]. Professional products were applied once before a five-day erosive cycle, involving six 2-minute citric-acid exposures per day. In combined-groups, a home-use dental-care product was applied daily at the end of each cycle day. After the cycle, lesion depth and fluorescence were analyzed using confocal-laser-scanning-microscopy, and results were statistically evaluated using paired t-tests, ANOVA, and Tukey's post-hoc tests.</p><p><strong>Results: </strong>The P<sub>11</sub>-4 group was significantly more effective among the professional-only groups in both parameters (p<0.001). All combined-groups were determined to be statistically more successful than their respective professional-groups in both parameters (p<0.05). Based on lesion depth data, it was observed that the P<sub>11</sub>-4 and stannous-containing combined-groups showed statistically similar results (p>0.05). In terms of lesion fluorescence data, the P<sub>11</sub>-4 combined-group was found to be statistically more successful than all other study groups (p<0.05).</p><p><strong>Conclusion: </strong>The self-assembling peptide P<sub>11</sub>-4 was determined to exhibit the best preventive and protective anti-erosive effect in both professional and combined applications.</p><p><strong>Clinical relevance: </strong>A positive relationship was observed between the support of professional applications with home-use daily-dental-care products and protection against erosive lesions.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"29"},"PeriodicalIF":3.1,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of 850 nm LED irradiation on the alignment of crowded mandibular anterior teeth: a randomized controlled clinical trial.","authors":"Nasrin Farhadian, Amirfarhang Miresmaeili, Homa Farhadifard, Ziba Banisafar, Maryam Farhadian, Vahid Beiglar, Yousef Ahmadpour","doi":"10.1007/s00784-024-06044-z","DOIUrl":"10.1007/s00784-024-06044-z","url":null,"abstract":"<p><strong>Introduction: </strong>This study aims to determine if intraoral 850 nm LED irradiation could reduce the duration of lower anterior crowding alignment.</p><p><strong>Methods: </strong>In a parallel-designed, randomized controlled clinical trial 60 patients with 2 to 6 mm of lower incisor crowding who need non-extraction treatment, were randomly assigned to the intervention and control groups by block randomization (36 females, 24 males, mean age: 19.93 ± 3.05). MBT brackets (0.022 × 0.28-inch) were bonded for both groups and the NiTi wires in sequences were put in place until correction of crowding. The intra-oral LED device with a wavelength of 850 nm and power density of 70 mW/cm<sup>2</sup> was used for 5 min per day in the intervention group. The control group did not receive any light. The primary outcome was the duration of crowding correction. The patient's pain according the modified McGill pain questionnaire was the secondary outcome. The Cox regression model was used to compare groups. Mann-Whitney test was used for pain analysis.</p><p><strong>Results: </strong>The crowding at baseline was the same between the two groups (P > 0.05). Duration of treatment in the intervention group was 104.7 days (95% CI: 95.6 -113.8) and significantly shorter than 161.9 days (95% CI: 151.5 -171.2) in the control group. The control group experienced a significantly higher pain score of 6.8 (95% CI: 6.1-7.5) immediately after archwire placement than the intervention group 5.4 (95% CI: 4.6-6.3).</p><p><strong>Conclusions: </strong>Intra-oral LED 850 nm significantly decreased the relieving time of lower incisor crowding by up to 36% and reduced pain experience.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"30"},"PeriodicalIF":3.1,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142892605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clemens Raabe, Emilio Couso-Queiruga, Jennifer Tjokro, Daniel Buser, Michael M Bornstein, Manrique Fonseca, Frank Schwarz, Vivianne Chappuis
{"title":"Analysis of trends in the context of implant therapy in a university surgical specialty clinic: a 20-year retrospective study.","authors":"Clemens Raabe, Emilio Couso-Queiruga, Jennifer Tjokro, Daniel Buser, Michael M Bornstein, Manrique Fonseca, Frank Schwarz, Vivianne Chappuis","doi":"10.1007/s00784-024-06033-2","DOIUrl":"10.1007/s00784-024-06033-2","url":null,"abstract":"<p><strong>Objectives: </strong>To analyze the trends in the context of implant therapy in a 3-year patient population and compare it with data obtained over the last 20 years.</p><p><strong>Materials and methods: </strong>All adult subjects who received treatment in the context of implant therapy between 2020 and 2022 were included in this retrospective study. Data regarding patient demographics, indications and location of implant therapy, implant characteristics, surgical techniques, complications, and early implant failures were recorded and compared to data obtained in the years 2002-2004, 2008-2010, and 2014-2016.</p><p><strong>Results: </strong>Between 2020 and 2022, n = 1555 implants were placed in n = 1021 patients. The mean age at implant placement was 59.9 + 15.1 years, demonstrating an increase over time in the age group 61-80 years of 23.1% and > 80 years of 3.2% (p < 0.0001). Single tooth gaps (48.9%) remained the main indication. The use of narrow diameters ≤ 3.5 mm increased (9.4% vs. 26.6%, p < 0.0001), while implant lengths > 10 mm decreased (45.7% vs. 23.5%, p < 0.0001). A reduction in more invasive techniques and an increase in computer-assisted implant surgeries (CAIS) of 19.5% was found.</p><p><strong>Conclusions: </strong>The mean age of patients receiving dental implant therapy, with the use of narrow-diameter and shorter implants has progressively increased in the last 20 years. The observed trends suggest a transition from conventional to CAIS, accompanied by the introduction of minimally invasive surgical techniques.</p><p><strong>Clinical relevance: </strong>The adoption of narrower and shorter implants, along with minimally invasive techniques and CAIS, enables clinicians to tailor treatment plans that accommodate the unique needs of aging patients and optimize clinical outcomes.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"27"},"PeriodicalIF":3.1,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11666676/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142876322","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yang Li, Wen Li, Haotian Xiao, Weizhong Chen, Jie Lu, Nengwen Huang, Qingling Li, Kangwei Zhou, Ikuho Kojima, Yiming Liu, Yanjing Ou
{"title":"Automated classification of pathological differentiation in head and neck squamous cell carcinoma using combined radiomics models from CET1WI and T2WI.","authors":"Yang Li, Wen Li, Haotian Xiao, Weizhong Chen, Jie Lu, Nengwen Huang, Qingling Li, Kangwei Zhou, Ikuho Kojima, Yiming Liu, Yanjing Ou","doi":"10.1007/s00784-024-06110-6","DOIUrl":"10.1007/s00784-024-06110-6","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to develop an automated radiomics-based model to grade the pathological differentiation of head and neck squamous cell carcinoma (HNSCC) and to assess the influence of various magnetic resonance imaging (MRI) sequences on the model's performance.</p><p><strong>Materials and methods: </strong>We retrospectively analyzed MRI data from 256 patients across two medical centers, including both contrast-enhanced T1-weighted images (CET1WI) and T2-weighted images (T2WI). Regions of interest were delineated for radiomics feature extraction, followed by dimensionality reduction. An XGBoost classifier was then employed to build the predictive model, with its classification efficiency assessed using receiver operating characteristic curves and the area under the curve (AUC).</p><p><strong>Results: </strong>In validation cohort, the AUC (macro/micro) values for models utilizing CET1WI, T2WI, and the combination of CET1WI and T2WI were 0.801/0.814, 0.741/0.798, and 0.885/0.895, respectively. The AUC for the three differentiations, ranging from well-differentiated to poorly differentiated, were 0.867, 0.909, and 0.837, respectively. The macro/micro precision, recall, and F1 scores of 0.688/0.736, 0.744/0.828, and 0.685/0.779 for the CET1WI + T2WI model.</p><p><strong>Conclusion: </strong>This study demonstrates that constructing a radiomics model based on CET1WI and T2WI sequences can be used to predict the pathological differentiation grading of HNSCC patients.</p><p><strong>Clinical relevance: </strong>This study suggests that a radiomics model integrating CET1WI and T2WI MRI sequences can effectively predict the pathological differentiation of HNSCC, providing an alternative diagnostic approach through non-invasive preoperative methods.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"25"},"PeriodicalIF":3.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Anna-Luisa Klotz, Stefanie Hagspiel, Christopher Büsch, Stephanie Zenthöfer, Peter Rammelsberg, Andreas Zenthöfer
{"title":"Mid-term survival and complications of double-crown-retained removable dental prostheses placed in the dental practice - a retrospective study.","authors":"Anna-Luisa Klotz, Stefanie Hagspiel, Christopher Büsch, Stephanie Zenthöfer, Peter Rammelsberg, Andreas Zenthöfer","doi":"10.1007/s00784-024-06090-7","DOIUrl":"10.1007/s00784-024-06090-7","url":null,"abstract":"<p><strong>Objectives: </strong>Clinical data on the performance of double-crown-retained removable dental prostheses (dcRDPs), especially beyond university studies, are rare. The objective of this retrospective clinical study was to evaluate the survival and complication-freeness probabilities of dcRDPs and to identify risk factors for failure and complications in a dental practice setting.</p><p><strong>Materials and methods: </strong>Anonymized practice data of 174 patients (56.9% female) fitted with a total of 213 dcRDPs (mean of 3.3 abutment teeth per dcRDP) were evaluated up to 11 years after prothesis placement (mean observation time of 3.9 years). Probabilities of survival and complication freeness were calculated on the prosthesis- and abutment level and visualized using the Kaplan-Meier method. Factors influencing failure and complications were computed using Cox regression analyses (R Ver. 7; alpha < 0.05).</p><p><strong>Results: </strong>During our observation period, 39 (18%) of the dcRDPs failed. The mean (95% CI) overall survival was 94% (90-97%) after 2 years and 86% (80-92%) after 5 years. DcRDP survival correlated with lower patient age and more abutment teeth (P < 0.05), while other analyzed factors did not. The probability of absence of prosthesis-related complications was 92% after 2 years and 80% after 5 years. The probability of no technical complications of abutments (teeth/implants) was 85% after 2 years and 78% after 5 years, and the probability of no biological complications was 87% after 2 years and 72% after 5 years. In total, 141 dcRDPs (66.2%) faced at least one complication during the observation period.</p><p><strong>Conclusions: </strong>Double-crown-retained prostheses fitted in a dental practice had acceptable mid-term survival rates and common technical and biological complications that were frequently easily manageable. However, prosthesis performance depended on the quality and number of abutment teeth/implants. Within the limitations of this retrospective analysis, the outcomes we observed in a dental practice are comparable to, albeit slightly worse than, those found in university studies.</p><p><strong>Clinical relevance: </strong>Evaluation of the clinical performance of dcRDPs fitted in a dental practice is important to estimate durability and complication patterns in order to weigh treatment decisions.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"26"},"PeriodicalIF":3.1,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11663171/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142871615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}