Clinical Oral Investigations最新文献

{"title":"Characterization of a new shape memory composite material for orthodontic aligners - a preliminary study.","authors":"Kang-Jie Cheng, Ang Wang, Yu-Xuan Ma, Ye Tian, Russell Wang, Yun-Feng Liu","doi":"10.1007/s00784-025-06486-z","DOIUrl":"10.1007/s00784-025-06486-z","url":null,"abstract":"<p><strong>Objective: </strong>Clear orthodontic appliances without metal brackets are highly favored by orthodontic patients due to their aesthetic appearance, easy to clean, and comfort. This pilot study aimed to investigate a new shape memory polyurethane (SMP) composite material for orthodontic applications.</p><p><strong>Methods: </strong>Finite element (FE) analysis was used to evaluate the mechanical performance of the composite material, which consists of polydl-lactide and hydroxyapatite (PDLLA/HA) model based on viscoelasticity and phase transition theories. Experimental characterization included determination of glass transition temperature (T_g), tensile properties, and creep behaviors. A customized UMAT subroutine was developed for Abaqus to simulate the thermodynamic process of shape memory effect based on the experimental data. Orthodontic forces generated by aligners fabricated from the composite were evaluated under simulated intraoral conditions.</p><p><strong>Results: </strong>The results showed a progressive decline in T_g of the SMP samples following immersion in water, with T_g values decreasing to 45, 37, and 35 ℃ after 5, 10, and 15 days, respectively. When displacing teeth 0.1, 0.2, and 0.3 mm facially using this aligner, the initial orthodontic forces recorded were approximately 0.16, 0.17, and 0.35 N, respectively, achieving 85.3% agreement with the FE simulation results.</p><p><strong>Conclusions: </strong>PDLLA/HA composite exhibits an appropriate and stable shape recovery force under simulated oral conditions, indicating its potential suitability for application in orthodontic treatment.</p><p><strong>Clinical relevance: </strong>Incorporating FE analysis enables the prediction of orthodontic forces exerted by clear aligners under various malocclusion conditions, thereby optimizing orthodontic treatment plans in clinical practice.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"399"},"PeriodicalIF":3.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793637","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fluoride application in middle childhood. A cross-sectional study.","authors":"Vera Wiesmüller, Stephanie Müller, Amelie Großhans, Ulrike Lepperdinger, Ines Kapferer-Seebacher","doi":"10.1007/s00784-025-06477-0","DOIUrl":"10.1007/s00784-025-06477-0","url":null,"abstract":"<p><strong>Objectives: </strong>Fluoride application is crucial for caries prevention; yet guidelines for middle childhood remain limited. This study evaluated the daily fluoride exposure of children aged six to 12 years and compare the findings with the available recommendations.</p><p><strong>Methods: </strong>Children applied their usual amount of toothpaste to a manual toothbrush, which was weighed before and after application. Additionally, data on residence in relation to fluoridation of tap water, frequency of oral hygiene practices, the oral hygiene products used, additional fluoride supplementation, and parental knowledge regarding fluoride prophylaxis was collected to determine daily fluoride exposure. The data were analysed in accordance with current recommendations.</p><p><strong>Results: </strong>The study included 458 children aged 8.0 ± 1.77 years. Age-appropriate toothpaste was used by 76.4%. The mean quantity of toothpaste utilised was 0.42 ± 0.27, while 0.5-0.75 g are recommended. The mean daily fluoride intake via toothpaste was found to be 1.01 ± 0.81 mg. 94.1% of the study cohort does not meet the recommendations of the German Society for Preventive Dentistry. Only a third of the cohort used at least one supplementary fluoride source in addition to toothpaste (37.7%). 43.48% of legal guardians expressed the opinion that fluoride prophylaxis is recommended for their child.</p><p><strong>Conclusions: </strong>The results highlight an urgent need for parental education.</p><p><strong>Clinical relevance: </strong>In an area of low-fluoridated drinking water children over six years should use a full brush length (>0.5 g) of fluoridated toothpaste (approximately 1450 ppm) twice daily, along with an additional fluoride source such as fluoridated salt, mouthwashes or gels. Study register of the University Hospital Innsbruck (clinical trial registration number 20220331-2872).</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"398"},"PeriodicalIF":3.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331857/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flap size as a confounding variable in flap perfusion measurement with the Oxygen-to-see (O2C) analysis system in microvascular head and neck reconstruction - a retrospective analysis.","authors":"Mark Ooms, Philipp Winnand, Marius Heitzer, Anna Bock, Marie Sophie Katz, Johannes Bickenbach, Frank Hölzle, Ali Modabber","doi":"10.1007/s00784-025-06468-1","DOIUrl":"10.1007/s00784-025-06468-1","url":null,"abstract":"<p><strong>Objectives: </strong>The Oxygen-to-see (O2C) analysis system is used for flap monitoring based on predefined threshold values for flap perfusion. However, flap size may be a confounding variable. The aim of this study was to investigate the relationship between flap size and flap perfusion in microvascular head and neck reconstruction.</p><p><strong>Materials and methods: </strong>Flap perfusion values measured with the O2C analysis system between 2011 and 2020 in 252 patients undergoing microvascular head and neck reconstruction with a radial free forearm flap (RFFF) or anterolateral thigh flap (ALTF) were retrospectively analyzed. Intraoperative and postoperative flap blood flow, hemoglobin concentration, and hemoglobin oxygen saturation at 8- and 2-mm tissue depths were compared between small (≤ median flap size) and large flaps (> median flap size) for RFFFs and ALTFs separately.</p><p><strong>Results: </strong>Intraoperative and postoperative hemoglobin concentration at a 2-mm tissue depth differed between small and large ALTFs (65.0 arbitrary units [AU] vs. 51.0 AU, p = 0.007; and 51.5 AU vs. 39.0 AU, p = 0.019). Both differences persisted in multivariable analysis (p < 0.001 and p = 0.012). Other differences were not observed or did not persist in multivariable analysis for RFFFs and ALTFs (all p > 0.05).</p><p><strong>Conclusions: </strong>Microvascular free flap perfusion is not related to flap size in terms of flap blood flow and hemoglobin oxygen saturation. This underscores the validity of predefined absolute threshold values in the context of flap monitoring based on perfusion measurement with the O2C analysis system.</p><p><strong>Clinical relevance: </strong>Flap perfusion measurement with the Oxygen-to-see (O2C) analysis system can be used for flap monitoring of small and large flaps.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"400"},"PeriodicalIF":3.1,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12331801/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144793638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of psychosis and oral health: case-control study.","authors":"Uta Christine Wölfle, Franziska Beck, Nils Werner, Vinay Pitchika, Katrin Heck, Matthias Folwaczny, Falk Schwendicke, Emanuel Boudriot, Sophie-Kathrin Greiner, Alkomiet Hasan, Peter Falkai, Lisa Löhrs, Caspar Victor Bumm","doi":"10.1007/s00784-025-06463-6","DOIUrl":"10.1007/s00784-025-06463-6","url":null,"abstract":"<p><strong>Objectives: </strong>Roughly one in eight individuals presents with psychiatric disorders which were proposed to significantly affect oral health. This study compared oral health of 112 patients (mean 28 years), 31 with schizophrenia spectrum disorders (SSD) or 33 with major depression/bipolar disorders (MDD/BD) to 52 healthy controls (HCG).</p><p><strong>Materials and methods: </strong>Oral health parameters, including caries experience (decayed-missed-filled teeth/surfaces-index DMFT/DMFS), the presence of plaque (plaque-index PI) and periodontal health (bleeding on probing BOP, periodontal probing depths PPD%), were evaluated by examiners blinded to psychiatric diagnoses. Descriptive statistics summarized demographic and clinical data. Group differences and associations with dental outcomes were analyzed using Chi-square or Mann-Whitney-U tests. Logistic regression identified predictors of oral health.</p><p><strong>Results: </strong>Patients with SSD or MDD/BD resented with significantly oorer oral health than HCG regarding DMFT (SSD = 9; MDD/BD = 10; HCG = 2), DMFS (SSD = 10; MDD/BD = 12; HCG = 1), PI (SSD = 2; MDD/BD = 2; HCG = 1), BOP (SSD = 20%; MDD/BD = 17%; HCG = 3)% and PPD% (SSD = 1%; MDD/BD = 0%; HCG = 0%) and smoked more often. Differences regarding dental anxiety were not significant (p = 0.112). Subgroup analysis showed no differences between SSD and MDD/BD.</p><p><strong>Conclusions: </strong>SSD and MDD/BD and smoking are key contributors to poor dental health shown by significantly worse DMFT, DMFS and PI, BOP. Probably this might additionally be enhanced by concomitant medication, with multiple psychiatric medication being associated with poorer oral health regarding DMFT, PI and BOP.</p><p><strong>Clinical relevance: </strong>Routine dental care and personalized oral hygiene training to address disease-specific risks are desirable for individuals with SSD or MDD/BD.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"397"},"PeriodicalIF":3.1,"publicationDate":"2025-08-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325445/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated classification of skeletal malocclusion in German orthodontic patients.","authors":"Eva Paddenberg-Schubert, Kareem Midlej, Sebastian Krohn, Erika Kuchler, Nezar Watted, Peter Proff, Fuad A Iraqi","doi":"10.1007/s00784-025-06485-0","DOIUrl":"10.1007/s00784-025-06485-0","url":null,"abstract":"<p><strong>Objectives: </strong>Precisely diagnosing skeletal class is mandatory for correct orthodontic treatment. Artificial intelligence (AI) could increase efficiency during diagnostics and contribute to automated workflows. So far, no AI-driven process can differentiate between skeletal classes I, II, and III in German orthodontic patients. This prospective cross-sectional study aimed to develop machine- and deep-learning models for diagnosing their skeletal class based on the gold-standard individualised ANB of Panagiotidis and Witt.</p><p><strong>Materials and methods: </strong>Orthodontic patients treated in Germany contributed to the study population. Pre-treatment cephalometric parameters, sex, and age served as input variables. Machine-learning models performed were linear discriminant analysis (LDA), random forest (RF), decision tree (DT), K-nearest neighbours (KNN), support vector machine (SVM), Gaussian naïve Bayes (NB), and multi class logistic regression (MCLR). Furthermore, an artificial neural network (ANN) was conducted.</p><p><strong>Results: </strong>1277 German patients presented skeletal class I (48.79%), II (27.56%) and III (23.64%). The best machine-learning model, which considered all input parameters, was RF with 100% accuracy, with Calculated_ANB being the most important (0.429). The model with Calculated_ANB only achieved 100% accuracy (KNN), but ANB alone was inappropriate (71-76% accuracy). The ANN with all parameters and Calculated_ANB achieved 95.31% and 100% validation-accuracy, respectively.</p><p><strong>Conclusions: </strong>Machine- and deep-learning methods can correctly determine an individual's skeletal class. Calculated_ANB was the most important among all input parameters, which, therefore, requires precise determination.</p><p><strong>Clinical relevance: </strong>The AI methods introduced may help to establish digital and automated workflows in cephalometric diagnostics, which could contribute to the relief of the orthodontic practitioner.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 8","pages":"396"},"PeriodicalIF":3.1,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12325434/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144783660","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of dental curing units and output modes regarding radiant flux, tip diameter, radiant emittance, scattering, and penetration depth.","authors":"Bora Korkut, Cevdet Can Saygili, Naci Murat, Ezgi Tuter Bayraktar, Rafael S Beolchi, Bilge Tarcin","doi":"10.1007/s00784-025-06482-3","DOIUrl":"10.1007/s00784-025-06482-3","url":null,"abstract":"<p><strong>Objective: </strong>To compare radiant flux, radiant emittance, light scattering, and penetration depth of high-power and low-power dental LED curing units (LCUs) and different output modes.</p><p><strong>Materials and methods: </strong>Ten different, brand-new dental LCUs and different output modes were tested by a laboratory-grade spectroradiometer to evaluate radiant flux and spectral emission. Two radiant emittance values were calculated using the radiant flux values for each curing unit/output mode, together with manufacturer's tip diameter or measured internal tip diameter. Light source width, scattering, total penetration depth (TPD), and main penetration depth (MPD) were also assessed through collected light beam images using Rhodamine B solution. Image processing was done using the Photoshop software to measure the distances. The deemed significance was set at < 0.050 for the statistical analyses.</p><p><strong>Results: </strong>Measured internal tip diameters were different than stated diameters for all LCUs except Valo X. Valo X Xtra Power mode delivered the highest radiant flux (2704 ± 5 mW), followed by Valo Grand Xtra Power mode (2576 ± 6 mW)(P <.001). The lowest radiant flux was from D Light Pro Low Power mode (449 ± 9 mW)(P <.001). Calculated radiant emittances based on the manufacturer's stated and measured internal tip diameters were up to 27.6% lower than the stated radiant emittances. A positive correlation was observed for TPD, light source width, and radiant emittance (P <.001). Scattering had negative correlations with TPD (P =.014), radiant emittance (P =.003), and tip diameter (P =.007).</p><p><strong>Conclusions: </strong>The radiant emittance can deviate from the manufacturer's stated values by up to 27.6%. Regular spectroradiometer measurements can be beneficial in this regard to adjust the curing time and thereby calibrate the clinical curing dose. Greater penetration depth can be expected when using LCUs with greater radiant emittance and tip diameter, while the curing mode was considered ineffective on the scattering pattern.</p><p><strong>Clinical relevance: </strong>Effective light-curing is a complicated clinical procedure in dentistry requiring many parameters. There might be some deviations in these features from the manufacturer's stated values. Clinicians should select the LCUs by considering the radiant flux, tip diameter, radiant emittance, light scattering, and penetration depth features to succeed in clinical restorative procedures.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 8","pages":"395"},"PeriodicalIF":3.1,"publicationDate":"2025-08-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From infancy to toddlerhood: A 3D analysis of facial asymmetry in children with and without orofacial clefts.","authors":"Katarína Martinková, Lenka Kožejová Jaklová, Karolina Kočandrlová, Jiří Borský, Ján Dupej, Alexander Morávek, Jana Velemínská","doi":"10.1007/s00784-025-06484-1","DOIUrl":"10.1007/s00784-025-06484-1","url":null,"abstract":"<p><strong>Objectives: </strong>This study investigates facial directional asymmetry (DA) in early childhood. Using 3D imaging, it aims to assess the DA progression in healthy controls and children with unilateral cleft lip (CL) and unilateral cleft lip and palate (UCLP) following early neonatal cheiloplasty and palatoplasty.</p><p><strong>Materials & methods: </strong>The sample consisted of 105 children (groups: cleft 42, control 63) aged 0.2-2 years. DA was analysed using geometric morphometrics, including 3D landmark-based and polygonal mesh analyses. Multivariate statistics were used for assessing DA significance and age group differences.</p><p><strong>Results: </strong>Controls showed no DA in landmarks and only mild protrusion of the right hemiface, increasing with age. In groups with cleft, DA was more pronounced in UCLP and especially in the middle of the face. While older UCLP children showed more asymmetrical faces, DA in children with CL became more comparable to that in controls with increasing age. Older children showed no statistical difference between control and CL in the landmark and polygonal maps parts.</p><p><strong>Conclusions: </strong>After surgical treatment, a DA pattern was identified, and it was specific for both cleft types and age categories. For both diagnoses, the most notable feature is the protrusion at the cleft site, likely related to post-surgical scarring, but in the UCLP group, it is also the hypoplastic nasal wing and a growth insufficiency of the cheek on the cleft side.</p><p><strong>Clinical relevance: </strong>3D methodologies provide insight into asymmetry progression and surgical outcomes, supporting improved cleft management for enhanced aesthetic and functional results.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 8","pages":"394"},"PeriodicalIF":3.1,"publicationDate":"2025-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144768513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with oral candidosis and hyposalivation in intensive care unit patients: a prospective cohort study.","authors":"Sarah Emily Melo da Silva, Romana Rênery Fernandes, Maria Eduarda Marques da Silva, Héverton Oliveira Duarte, Rosângela Oliveira da Câmara, Maria Luiza Diniz de Sousa Lopes, Ana Rafaela Luz de Aquino Martins, Éricka Janine Dantas Da Silveira","doi":"10.1007/s00784-025-06465-4","DOIUrl":"10.1007/s00784-025-06465-4","url":null,"abstract":"<p><strong>Objective: </strong>To separately investigate the occurrence of oral candidosis and hyposalivation in Intensive Care Unit (ICU) patients and identify contributing factors.</p><p><strong>Methods: </strong>A prospective cohort study was conducted with 100 ICU patients in a hospital in northeastern Brazil. Detailed intraoral examinations were performed daily by calibrated dentists, and sociodemographic and general health-related data were extracted from medical records. Pearson's Chi-square or Fisher's exact test assessed variable associations. Survival analysis estimated the onset time of oral candidosis and hyposalivation and their associations with risk factors.</p><p><strong>Results: </strong>Among the 100 patients, 65% developed hyposalivation, and 11% presented oral candidiasis. The median age was 64 years, with a predominance of males. No significant associations were found between oral candidiasis and demographic or clinical variables. Hyposalivation was significantly linked to underlying renal disease, anemia, and the use of medications such as antibiotics, corticosteroids, anticholinergics, and bronchodilators. Co-occurrence of candidosis and hyposalivation were observed in 7 patients. There was no statistically significant association of the development of oral candidosis or hyposalivation with other oral changes. Anticoagulant use was significantly associated with a higher oral candidiasis-free survival rate. Underlying renal disease, antibiotic treatment, and orotracheal intubation were significantly associated with a reduced survival rate free from hyposalivation.</p><p><strong>Conclusions: </strong>Hyposalivation was highly prevalent and may be linked to the development of other oral conditions, such as oral candidosis. Understanding factors that contribute to hyposalivation and oral candidosis is essential for improving ICU healthcare and enhancing patient recovery.</p><p><strong>Clinical relevance: </strong>Early identification and management of hyposalivation should be prioritized in ICU protocols to enhance patient recovery and oral health care.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 8","pages":"392"},"PeriodicalIF":3.1,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of platelet-rich fibrin on microperfusion during early socket healing: a randomized controlled clinical trial.","authors":"Marie Sophie Katz, Mark Ooms, Marius Heitzer, Maurice Klein, Philipp Winnand, Timm Steiner, Frank Hölzle, Ali Modabber","doi":"10.1007/s00784-025-06470-7","DOIUrl":"10.1007/s00784-025-06470-7","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate and compare the early healing of fresh alveolar sockets treated with or without platelet-rich fibrin (PRF) using laser Doppler flowmetry and tissue spectrophotometry (LDF-TS). The primary outcome was gingival perfusion; secondary outcomes included clinical wound healing (based on the Landry Wound Healing Index) and patient-reported postoperative pain.</p><p><strong>Materials and methods: </strong>Sixty-two patients requiring single tooth extraction were randomized into two groups. In the PRF group, an advanced PRF (A-PRF+) plug was placed in the socket before suturing; in the control group, only suturing was performed. Gingival perfusion was measured at four sites preoperatively and on postoperative days 3 and 10 using LDF-TS. Patients rated pain, and wound healing was clinically assessed. Twelve patients were lost to follow-up, leaving 50 for analysis.</p><p><strong>Results: </strong>No significant differences were found between the PRF and control group regarding pain (day 3: p = 0.654; day 10: p = 0.329) or wound healing (day 3: p = 0.178; day 10: p = 0.595). Perfusion parameters also showed no significant group differences between baseline and day 10: oxygen saturation (SO₂: p = 0.884), relative hemoglobin (rHb: p = 0.387), and blood flow (p = 0.072).</p><p><strong>Conclusions: </strong>Gingival perfusion showed no significant group differences over 10 days. PRF did not significantly reduce pain or improve wound healing.</p><p><strong>Clinical relevance: </strong>PRF does not appear to significantly enhance healing, pain reduction, or perfusion in simple extractions. Future studies should use split-mouth designs and focus on more complex surgeries to better evaluate PRF's effects.</p><p><strong>Trial registration: </strong>All procedures performed in this study involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The study was performed according to the Consolidated Standards of Registered Trial (CONSORT) guidelines. The study was approved by the institutional Clinical Research Ethics Committee (Decision Number 23-105) and by the German Clinical Trials Register (File Number DRKS00032344, registered on October 11, 2023).</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 8","pages":"393"},"PeriodicalIF":3.1,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12307558/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Prediction of nodal disease in oral squamous cell carcinoma of the tongue: histopathological risk assessment with the focus on depth of invasion.","authors":"Friedrich Mrosk, Viktor Krom, Christian Doll, Lukas Mödl, Kilian Kreutzer, Jan Voss, Carsten Rendenbach, Max Heiland, Steffen Koerdt","doi":"10.1007/s00784-025-06469-0","DOIUrl":"10.1007/s00784-025-06469-0","url":null,"abstract":"","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 8","pages":"391"},"PeriodicalIF":3.1,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12304059/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}