Clinical Oral Investigations最新文献

{"title":"Elevated levels of salivary interleukin-34 in patients suffering from Alzheimer's disease.","authors":"Reuben Clark, Ronaldo Lira-Junior, Leif Jansson, Maria Eriksdotter, Marianne Schultzberg, Pirkko Pussinen, Kåre Buhlin, Elisabeth A Boström","doi":"10.1007/s00784-025-06376-4","DOIUrl":"10.1007/s00784-025-06376-4","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate interleukin (IL)-34 and colony-stimulating factor (CSF)-1 levels in saliva, cerebrospinal fluid, and plasma in different stages of cognitive impairment. The study also examines the relationship between these biomarkers and periodontal status across different stages of cognitive impairment.</p><p><strong>Material and methods: </strong>A total of 230 individuals diagnosed with Alzheimer's disease (AD, n = 52), mild cognitive impairment (MCI, n = 51), subjective cognitive impairment (SCI, n = 51), and controls (n = 76) were enrolled. Participants underwent clinical and radiological oral examinations. Cerebrospinal fluid samples were collected from all groups except controls. Stimulated saliva and blood were collected during oral examination. IL-34 and CSF-1 levels were assessed using enzyme-linked immunosorbent assays.</p><p><strong>Results: </strong>Salivary IL-34 levels were increased in AD compared to SCI (p = 0.010) and controls (p < 0.001), and in MCI compared to controls (p < 0.001). Elevated salivary CSF-1 levels were observed in AD compared to SCI (p = 0.003). Salivary IL-34 was inversely associated with Mini-Mental State Examination (MMSE) scores (p < 0.010) and body mass index (p = 0.040), while CSF-1 was associated with age (p = 0.015). IL-34 and CSF-1 levels did not differ in cerebrospinal fluid between groups, and periodontal status did not affect the levels in any biofluid measured.</p><p><strong>Conclusion: </strong>Salivary IL-34 is increased in AD patients and is associated with MMSE scores.</p><p><strong>Clinical relevance: </strong>Identifying reliable biomarkers for AD is crucial for early detection and intervention. This study suggests that salivary IL-34 could serve as a potential biomarker for AD.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"303"},"PeriodicalIF":3.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089168/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative analysis of gingival crevicular fluid and peri-implant crevicular fluid by mid-infrared spectroscopy: a split mouth study.","authors":"Francisco Maligno, Ricardo N M J Páscoa, Pedro S Gomes","doi":"10.1007/s00784-025-06382-6","DOIUrl":"10.1007/s00784-025-06382-6","url":null,"abstract":"<p><strong>Objectives: </strong>This proof-of-concept study aimed to compare the biochemical composition of gingival crevicular fluid (GCF) and peri-implant crevicular fluid (PICF) under healthy conditions, through mid-infrared (MIR) spectroscopy.</p><p><strong>Materials and methods: </strong>Using a split-mouth design, GCF and PICF samples were collected from 12 participants and analyzed through MIR spectroscopy. Advanced chemometric models, including partial least squares-discriminant analysis, k-nearest neighbors, and support vector machine discriminant analysis, were applied to explore potential biochemical differences between the biofluids.</p><p><strong>Results: </strong>No cluster formation was observed with PCA, indicating a high degree of similarity between groups. The PLS-DA model didn't effectively discriminate between GCF and PICF with prediction rates of 62.5% (10/16) for calibration, 37.5% (6/16) for cross-validation, and 50% (4/8) for validation. The k-NN model, using k = 3 neighbors showed 25% (4/16) correct classification rates during calibration and a validation set accuracy of 50%. SVM-DA analysis showed a correct prediction rate of 37.5% (6/16) for calibration and 50% for cross-validation 50% (8/16) and 50% (4/8) in the validation phase. Nonetheless, subtle spectral differences were observed in spectral regions R1 (3982-2652 cm⁻¹) and R4 (1180-922 cm⁻¹), suggesting a slightly increased lipidic content and the presence of ethers and glycosidic bonds linked to carbohydrates, in PICF.</p><p><strong>Conclusions: </strong>The lack of significant biochemical differences between GCF and PICF under healthy conditions, as determined by MIR spectroscopy, suggests that implant-related changes in PICF composition are negligible.</p><p><strong>Clinical relevance: </strong>The demonstrated biochemical similarity between GCF and PICF under healthy conditions reinforces the potential of PICF as a reliable biofluid for diagnostic applications, including monitoring oral and systemic health biomarkers, without significant influence from implant-related factors.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"305"},"PeriodicalIF":3.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12092536/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of TheraCal PT and Biodentine on inflammatory cell infiltration and hard tissue formation after pulpotomy in inflamed or healthy rat molars.","authors":"Tuba Gok, Guzide Cankaya, Yesari Eroksuz, Canan Akdeniz Incili, Suna Karadeniz Saygili","doi":"10.1007/s00784-025-06372-8","DOIUrl":"10.1007/s00784-025-06372-8","url":null,"abstract":"<p><strong>Objectives: </strong>TheraCal PT is a novel resin-modified calcium-silicate material introduced for vital pulp therapies. This study aimed to investigate the inflammation and hard tissue formation after pulpotomy treatment with Biodentine and TheraCal PT in inflamed or healthy rat molar teeth.</p><p><strong>Methods: </strong>This study consisted of six groups (n = 12, 72 teeth): negative control-no preparation (NC); positive control (PC); Biodentine-pulpitis teeth (BD-P), TheraCal PT-pulpitis teeth (TPT-P), Biodentine-healthy teeth (BD-H), TheraCal PT-healthy teeth (TPT-P). For PC, BD-P and TPT-P groups, teeth were induced with lipopolysaccharide for 12 h. Pulpotomy procedure was performed with Biodentine and TheraCal PT. Eight weeks later, pulpal inflammatory cell infiltration and hard tissue formation were evaluated by histological analysis. Pearson's chi-square test was performed.</p><p><strong>Results: </strong>There were significant differences among groups for inflammation and hard tissue formation (p <.05). PC group showed moderate to severe inflammation. Biodentine groups showed lower inflammation scores than TheraCal PT groups. Pulpitis-induced groups showed higher inflammation scores than healthy groups. In Biodentine groups, complete hard tissue formation was higher than incomplete hard tissue formation. TheraCal PT groups showed mostly incomplete or no hard tissue formation. Pulpitis-induced groups showed inferior hard tissue formation scores than healthy groups.</p><p><strong>Conclusions: </strong>TheraCal PT as a pulp capping material and inflamed pulp as a pre-treatment tooth condition showed inferior results in pulpotomy treatment. Biodentine exhibited favorable inflammatory pulpal responses and thicker hard tissue formation than TheraCal PT.</p><p><strong>Clinical relevance: </strong>The novel resin-modified calcium-silicate material showed inferior inflammatory cell infiltration and hard tissue formation results in pulpotomy-treated teeth with irreversible pulpitis.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"301"},"PeriodicalIF":3.1,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12085342/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, tomographic, and histological analysis of post-extraction dental sockets filled with particulate dentin or blood clot: pilot study of a randomized clinical trial.","authors":"Tobias Piton Fontana, Pedro Henrique Corazza, Dora Marise Medeiros de Castro, Aline Bassani Deconto, Letícia Copatti Dogenski, Matheus Albino Souza, Juliane Bervian, Gisele Rovani, Micheline Sandini Trentin, João Paulo De Carli","doi":"10.1007/s00784-025-06374-6","DOIUrl":"10.1007/s00784-025-06374-6","url":null,"abstract":"<p><strong>Objective: </strong>This preliminary study aims to compare the clinical, radiological, and histological outcomes of third molar socket repairs after dental extraction with and without the use of particulate dentin graft.</p><p><strong>Materials and methods: </strong>Ten patients requiring bilateral surgical extraction of impacted lower third molars were selected. One side received a blood clot (control side) and the other an autologous particulate dentin graft (experimental side). Postoperative evaluations at 7 and 21 days assessed pain, edema, trismus, suture dehiscence, and wound edge coaptation. At 120 days, CBCT was used to evaluate bone density, and a biopsy was performed for histological analysis. Data were analyzed using IBM SPSS software with descriptive statistics and paired t-test at a 5% significance level.</p><p><strong>Results: </strong>At 21 days, only one case of suture dehiscence occurred on the experimental side, compared to three on the control side. No differences in pain, edema, or trismus were observed between groups. Tomographic analysis showed no significant difference in the distance from the alveolar bone crest to the CEJ, but the experimental group had significantly higher bone density (p = 0.002). Histologically, the experimental side exhibited thicker, denser connective tissue with higher cellularity, collagen production, and multinucleated giant cells, while the control side showed typical connective tissue with fewer multinucleated cells.</p><p><strong>Conclusion: </strong>Particulate dentin grafting showed benefits in bone density and clinical stability, with a more advanced histological healing stage.</p><p><strong>Clinical relevance: </strong>Improve post-extraction socket healing, offering a promising alternative to traditional methods, particularly in terms of enhancing bone regeneration and clinical outcomes.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"300"},"PeriodicalIF":3.1,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144085530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-dimensional pharyngeal airway and hyoid bone changes in skeletal class I malocclusion treated with extraction and non-extraction protocols: a comparative study of fixed orthodontic appliance and clear aligners.","authors":"Majedh Abdo Ali Al-Somairi, Yuwen Yan, Maged S Alhammadi, Naseem Ali Al-Worafi, Enas Senan Alyafrusee, Bushra Sufyan Almaqrami, Hasan M Sharhan, Barakat Al-Tayar, Bowen Zheng, Yi Liu","doi":"10.1007/s00784-025-06367-5","DOIUrl":"10.1007/s00784-025-06367-5","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to provide a comprehensive three-dimensional (3D) evaluation of fixed appliances (FAs) and clear aligners (CAs) on pharyngeal airway (PA) dimensions and hyoid bone (HB) positioning in skeletal Class I malocclusion patients treated with extraction and non-extraction protocols, comparing the effects within each protocol.</p><p><strong>Materials and methods: </strong>This retrospective study involved 120 adult patients divided into extraction and non-extraction groups, each further subdivided equally into those treated with FAs and CAs. PA segmentation and measurements were conducted with Dolphin 11.8 (Dolphin Imaging and Management Solutions, Chatsworth, CA). The PA was analyzed in the nasopharyngeal (NP), oropharyngeal (OP), and hypopharyngeal (HP), total pharyngeal (TP) airway, while HB parameters were measured using InVivo 6.0.3 (Anatomage, San Jose, CA). Descriptive and analytical statistics were performed, with a significance level set at P < 0.05.</p><p><strong>Results: </strong>None of the evaluated parameters showed a significant difference in the baseline, indicating almost comparable groups. Inter-group comparisons showed that within the non-extraction group, FAs caused greater decreases in OP sagittal width and HP lateral width and more significant increases in vertical hyoid position (H-FH) compared to CAs (P < 0.05). In the extraction group, FAs resulted in greater decreases in OP lateral width and volume, HP volume, and more significant H-FH increases than CAs (P < 0.05).</p><p><strong>Conclusion: </strong>Fixed appliances caused greater reductions in oropharyngeal and hypopharyngeal dimensions and more significant changes in hyoid bone position compared to clear aligners, particularly in extraction cases. Clinicians should consider these effects when selecting treatment modalities, especially for patients with airway concerns.</p><p><strong>Clinical relevance: </strong>Fixed appliances significantly impact pharyngeal airway dimensions and hyoid bone positioning, while clear aligners have milder effects, emphasizing the need for careful treatment planning.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"299"},"PeriodicalIF":3.1,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076539","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative analysis of substance removal during tooth preparation for full ceramic restorations using digitally generated preparation designs.","authors":"Kathrin Seidel, Kirsten Johannes, Eva Herrmann, Tuba Aini, Tugba Zahn, Jan-Frederik Güth","doi":"10.1007/s00784-025-06370-w","DOIUrl":"10.1007/s00784-025-06370-w","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to determine which factors most strongly affect volumetric tooth substance removal during preparation for full ceramic restorations and how these parameters interact. A novel digital method was used to design preparation geometries using three-dimensional (3D) graphic software.</p><p><strong>Materials and methods: </strong>A digital workflow involving Boolean operations was applied to an STL dataset of a maxillary first molar to generate 720 preparation designs. Each design varied by preparation angle, chamfer depth, finish line distance from the cementoenamel junction (CEJ), and occlusal reduction. Volumetric tooth removal was evaluated for each parameter, as well as for their combined effects.</p><p><strong>Results: </strong>All preparation parameters influenced tooth substance removal. The finish line distance from the CEJ showed the greatest effect, followed by chamfer depth. Preparation angle and occlusal reduction had less pronounced effects.</p><p><strong>Conclusions: </strong>Increasing the vertical finish line distance and minimizing chamfer depth substantially reduce tooth substance removal. While adequate occlusal clearance is essential, its effect on total volume loss is relatively minor. The influence of the preparation angle was more relevant for full crowns than for partial restorations.</p><p><strong>Clinical relevance: </strong>Clinicians are encouraged to favor partial restorations whenever possible, as they result in less invasive preparations, even when compared to full crowns made from high-strength materials with reduced thickness requirements such as monolithic zirconia. To preserve tooth structure, both the material's minimum thickness and the vertical position of the finish line should be carefully considered. These findings support a conservative preparation approach tailored to material properties and clinical requirements.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"298"},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985945","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of immediate pre-endodontic dentin sealing on the cuspal deflection and fracture strength of endodontically treated teeth.","authors":"Ahmed I M Al-Rubaie, Abdulla M W Al-Shamma","doi":"10.1007/s00784-025-06371-9","DOIUrl":"10.1007/s00784-025-06371-9","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to measure and compare the effects of immediate pre-endodontic dentin sealing (IPDS) and late dentin hybridization (LDh), combined with two different irrigation protocols (NaOCl/EDTA or normal saline), on cuspal deflection (CD) and fracture strength (FS) of endodontically treated teeth.</p><p><strong>Materials and methods: </strong>Sixty maxillary first premolars were divided into four experimental groups (A1: LDh + NS, A2: LDh + NaOCl/EDTA, B1: IPDS + NS, B2: IPDS + NaOCl/EDTA) and two control groups (C: sound teeth, D: unrestored teeth). Teeth underwent standardized MOD cavity preparation, endodontic treatment, and restoration, except for group D was left without restoration. CD was measured after cavity preparation, 15 min post-restoration, and after thermocycling. FS was assessed using a universal testing machine.</p><p><strong>Results: </strong>No significant CD differences were found after cavity preparation. However, 15 min post-restoration, LDh groups (A1, A2) exhibited significantly higher CD than IPDS groups (B1, B2), with A2 group CD being higher than A1 group. After thermocycling, IPDS groups demonstrated greater cuspal relaxation compared to LDh groups. FS was highest in sound teeth (1533.2N) and lowest in unrestored teeth (571.5N). IPDS groups had significantly higher FS than LDh groups, with no significant difference between B1 and B2 groups.</p><p><strong>Conclusions: </strong>The study concluded that IPDS reduces CD and enhances FS compared to LDh, suggesting it as an effective step before endodontic treatment. NaOCl/EDTA irrigation influenced CD and FS in LDh groups but had no significant impact in IPDS groups.</p><p><strong>Clinical relevance: </strong>Dentin sealing before root canal treatment and prior to exposure to chemical substances (such as irrigation with NaOCl) enhances the structural integrity of endodontically treated teeth. This protective measure protects the freshly cut dentin from the detrimental effects of these substances, thereby improving the bonding strength and overall clinical outcomes.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"297"},"PeriodicalIF":3.1,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143970099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of copaiba oil-resin on dental sensitivity control and color change after bleaching: A randomized clinical trial.","authors":"Giovana Solheid Gil, Gabriela Monteiro Barbosa Xavier, Caio Augusto de Almeida Canelas, Rafael Rodrigues Lima, Ana Paula Drummond Rodrigues, Jesuina Lamartine Nogueira Araújo, Marcele Fonseca Passos, Cecy Martins Silva","doi":"10.1007/s00784-025-06375-5","DOIUrl":"10.1007/s00784-025-06375-5","url":null,"abstract":"<p><strong>Objective: </strong>This randomized clinical trial evaluated a copaiba oil-based gel in controlling dental sensitivity (DS) and color change after dental bleaching.</p><p><strong>Materials and methods: </strong>Seventy-five volunteers were randomized into three groups (n = 25): GC (placebo gel - negative control); GKF2% (gel of 5% potassium nitrate and 2% sodium fluoride - positive control); and GCO (copaiba oil gel). Three bleaching sessions were performed using 35% hydrogen peroxide (HP 35%), with 7-day intervals. The desensitizing gels were applied for 10 min in each group. The DS was evaluated over 21 days using a visual analog scale (VAS). Color evaluation was done with a spectrophotometer before and after bleaching using the CIEDE2000. The DS was assessed between groups (Kruskal-Wallis test) and within groups (Friedman test). The color change was analyzed using one-way ANOVA and Tukey's test.</p><p><strong>Results: </strong>GCO and GKF2% showed the lowest sensitivity values, with no significant difference (p < 0.05). In the intragroup analysis, GCO and GKF2% showed no differences across the three whitening sessions (p = 0.974, p = 0.213, p = 0.143, respectively). Conversely, GC exhibited an increase in DS after the last session (p = 0.035). All groups showed color change, without statistically significant differences between the groups (p = 0.725).</p><p><strong>Conclusion: </strong>The copaiba gel reduced dental sensitivity after treatment with 35% hydrogen peroxide, without affecting the bleaching effectiveness.</p><p><strong>Clinical relevance: </strong>The topical application of the experimental copaiba oil gel was effective in reducing dental sensitivity after bleaching with 35% hydrogen peroxide.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"296"},"PeriodicalIF":3.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of dental arch width changes on the effective space required to align anterior teeth.","authors":"Fayez Elkholy, Catrin Gerhart, Falko Schmidt, Bernd G Lapatki","doi":"10.1007/s00784-025-06361-x","DOIUrl":"10.1007/s00784-025-06361-x","url":null,"abstract":"<p><strong>Aim: </strong>Traditionally, the widest mesio-distal tooth dimensions are used to analyze space requirements in treatment planning. However, in reality, it is the arch form dependent interproximal contact locations that determine the space required for tooth alignment. The aim of this study was to evaluate the influence of expansion and constriction of dental arch width on the space required for alignment of upper and lower incisors.</p><p><strong>Materials and methods: </strong>Fifty digital dental arch model pairs were segmented and aligned using OnyxCeph 3D™ software (Image Instruments, Germany). 3D coordinates of actual interproximal contact points were extracted from the digital setups. The mesio-distal space requirement for each tooth was determined by measuring the linear distance between its interproximal contact points projected on the occlusal plane. The dental arch was then expanded and narrowed in 2-mm increments at its distal ends, and the space requirement for each incisor was determined again after each increment.</p><p><strong>Results: </strong>Statistical analysis using linear models revealed a small increase in space required for incisor alignment with increasing arch width (p < 0.05). An average increase in space requirement of 0.03 mm and 0.04 mm was observed per 1-mm expansion of the maxillary and mandibular arches, respectively. The corresponding values ​​for constriction were 0.05 mm per 1-mm arch width change for both jaws.</p><p><strong>Conclusion: </strong>The influence of dental arch form on the mesio-distal space required for incisor alignment is negligible. Hence, this factor may be ignored in the decision to apply dental arch expansion or premolar extraction in patients with anterior crowding.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"295"},"PeriodicalIF":3.1,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075255/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143968193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effective mechanical vibration frequency in canine tooth movement acceleration: a systematic review and network meta-analysis of randomized controlled trial studies.","authors":"Tadd Lalitwageewong, Chidchanok Leethanakul, Teepawat Witeerungrot","doi":"10.1007/s00784-025-06338-w","DOIUrl":"10.1007/s00784-025-06338-w","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to evaluate the effectiveness of various supplementary vibrational frequencies with orthodontic force on the rate of canine movement.</p><p><strong>Materials and methods: </strong>A literature search was conducted in PubMed, Embase, Cochrane, Scopus, ClinicalTrials.gov, and Google Scholar, with the final search on February 17, 2025. Randomized controlled trials (RCTs) involving participants undergoing orthodontic treatment with upper first premolar extraction, assessed the effect of different vibration frequencies on canine movement rate were included. Study quality was assessed using the Risk of Bias (RoB) 2. A random-effects model (DerSimonian and Laird method) for pairwise meta-analysis (PMA) and a frequentist-based network meta-analysis (NMA) estimated relative effects, with mean difference (MD) and 95% confidence interval (CI) calculated for all comparisons. The certainty of evidence was assessed using the Confidence in Network Meta-Analysis tool.</p><p><strong>Results: </strong>Ten RCTs examined the effects of five vibration frequencies. The RoB ranged from low to high. The PMA found vibrations significantly increased tooth movement (MD = 0.084 mm, 95% CI [0.004, 0.164]). Conversely, NMA showed no significant differences across all comparisons. The Surface Under the Cumulative Ranking Curve ranked 125 Hz as the most effective, followed by 100, 60, 30, and 0 Hz. The confidence in evidence ranged from low to moderate.</p><p><strong>Conclusions: </strong>The use of supplementary vibration in conjunction with orthodontic force statistically effectively accelerates tooth movement, with higher frequencies showing a tendency to yield better acceleration results.</p><p><strong>Clinical relevance: </strong>While vibration therapy demonstrated a statistically significant effect on canine movement, the magnitude of this effect was not sufficient to be considered clinically significant for orthodontic treatment. Further research is required to optimize the effectiveness.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"292"},"PeriodicalIF":3.1,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143985941","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}