Clinical Oral Investigations最新文献

{"title":"Immunopathogenesis and immunotherapy of diabetes-associated periodontitis.","authors":"Shuangshuang Li, Shuang Li, Lingxiao Meng, Ruihan Gao, Hongrui Liu, Minqi Li","doi":"10.1007/s00784-024-06141-z","DOIUrl":"10.1007/s00784-024-06141-z","url":null,"abstract":"<p><strong>Objectives: </strong>This paper aims to review the immunopathogenesis of Diabetes-associated periodontitis (DPD) and to propose a description of the research progress of drugs with potential clinical value from an immunotherapeutic perspective.</p><p><strong>Materials and methods: </strong>A comprehensive literature search was conducted in PubMed, MEDLINE, Embase, Web of Science, Scopus and the Cochrane Library. Inclusion criteria were studies on the association between diabetes and periodontitis using the Boolean operator \"AND\" for association between diabetes and periodontitis, with no time or language restrictions. Search terms included diabetes mellitus, periodontitis, immunopathogenesis, specific immunity, non-specific immunity, flora, estrogen, pharmacological treatment, immunotherapy.</p><p><strong>Results: </strong>Alterations in the subgingival flora environment in a hyperglycemic environment elicit an immune response. Overactivity/suppression of nonspecific immune cells and impaired cellular defenses trigger specific immune responses. Epigenetics as well as female hormones also play a role. There is already a small amount of clinical evidence for the role of metronidazole, subantimicrobial doses of doxycycline, minocycline hydrochloride, and metformin in the treatment of DPD. Some preclinical studies have also accumulated experimental evidence for the improved effects of vitamin D3 and other drugs on DPD.</p><p><strong>Conclusions: </strong>The development of diabetic periodontitis is immunologically linked to a state of immune imbalance and therefore holds great promise for the use of immunotherapeutic drugs.</p><p><strong>Clinical significance: </strong>Immunotherapy with drugs along with periodontal nonsurgical treatment could provide ideas for DPD treatment based on the immunopathogenesis of DPD.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"44"},"PeriodicalIF":3.1,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142926569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of different adhesive strategies and diamond burs on dentin bond strength of universal resin cements.","authors":"Chavakorn Atsavathavornset, Pipop Saikaew, Choltacha Harnirattisai, Hidehiko Sano","doi":"10.1007/s00784-024-06112-4","DOIUrl":"10.1007/s00784-024-06112-4","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the shear bond strength (SBS) of universal cements (UCs) to dentin prepared with different diamond burs using various adhesive strategies.</p><p><strong>Materials and methods: </strong>One-hundred-twenty molars were prepared to expose the mid-coronal dentin. The teeth were divided into two groups according to diamond bur preparations: coarse and super-fine grit burs. The specimens were bonded to lithium disilicate discs using two UCs (RelyX Universal, RXU and Panavia SA Luting Multi, PSA) with different adhesive strategies (self-adhesive, SA; self-etch, SE and etch-and-rinse, ER). SBS was measured using a universal testing machine. The cement-dentin interfaces were observed using scanning electron microscopy.</p><p><strong>Results: </strong>Dentin SBS was significantly influenced by the adhesive strategies and the type of UCs (p < 0.05) but not for the different diamond bur preparations (p > 0.05). UCs used with ER had significantly higher SBS values than UCs used in SA mode (P < 0.05), except for PSA with super-fine diamond bur. RXU in SE mode exhibited significantly higher SBS than SA mode (P < 0.05). Regarding UCs, RXU showed a higher SBS than PSA, particularly in the SE modes when the dentin was prepared with a coarse diamond bur (P < 0.05).</p><p><strong>Conclusion: </strong>The use of UCs combined with universal adhesives exhibited higher dentin bonding performance compared with the use of UCs alone.</p><p><strong>Clinical significance: </strong>The etch-and-rinse mode combined with a universal adhesive is recommended to achieve the highest dentin bond strength of universal cements.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"41"},"PeriodicalIF":3.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11698786/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920311","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Selective outcome reporting concerning antibiotics and third molar surgery.","authors":"Thalita Guarda Fagoni, Vanessa Cristina Rafalovich, Mariana Aparecida Brozoski, Maria Cristina Zindel Deboni, Natacha Kalline de Oliveira","doi":"10.1007/s00784-024-06130-2","DOIUrl":"10.1007/s00784-024-06130-2","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluates the selective outcome reporting (SOR) in clinical trials on antibiotic use in third molar surgeries. It explores how SOR may bias results and affect systematic reviews, potentially leading to misinterpretations of intervention efficacy.</p><p><strong>Materials and methods: </strong>A search was conducted on \"ClinicalTrials.gov\", \"Brazilian Registry of Clinical Trials\", \"International Clinical Trials Registry Platform\" and \"European Union Clinical Trials Register\" using the terms \"third molar\" and \"antibiotics\" up to December 2024. Two independent researchers selected eligible clinical trials. Data were extracted from registered protocols and corresponding publications. Discrepancies were analyzed using established criteria, and the risk of bias of published articles was assessed with Risk of Bias2.</p><p><strong>Results: </strong>Discrepancies between protocols and publications were found in 87.5% of cases, affecting outcomes in 68.7% of studies. SOR significantly influenced results in studies with one or more discrepancies. 75% of studies assess pain post-antibiotic therapy; of those, 50% found significant results. Only 31,25% of studies showed significant reductions in trismus or edema with antibiotic use. The risk of bias varied significantly across studies.</p><p><strong>Conclusions: </strong>The high rate of selective reporting stresses the need for transparent studies to clarify the role of antibiotics in the perioperative period. Researchers should adhere to best clinical practices, including protocol registration, accurate sample size calculations, and precision in reporting. Journals and reviewers must prioritize transparency to reduce bias and improve research quality.</p><p><strong>Clinical relevance: </strong>This study emphasizes the impact of SOR in clinical trials using antibiotics in third molar surgery. Clinicians should be more cautious in reading evidence based on randomized clinical trials with SORs.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"42"},"PeriodicalIF":3.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing periodontitis risk from specific dietary patterns: a systematic review and meta-analysis.","authors":"Ru-Yi Fan, Jia-Xi Chen, Li-Li Chen, Wei-Lian Sun","doi":"10.1007/s00784-024-06125-z","DOIUrl":"10.1007/s00784-024-06125-z","url":null,"abstract":"<p><strong>Aims: </strong>Our goal is to perform a meta-analysis to investigate the risk of periodontitis associated with specific dietary patterns.</p><p><strong>Methods: </strong>We employed the PRISMA methodology in a meta-analysis to examine the correlation between dietary patterns and the risk of periodontitis. We systematically searched three online databases from inception to November 2024 to identify relevant studies. Summary estimates with 95%CI were calculated to assess the relationship between specific dietary patterns and the risk of periodontitis. Cumulative estimates were synthesized using random-effects or fixed-effects models. Heterogeneity among studies was evaluated using Cochran's Q and I² statistics.</p><p><strong>Results: </strong>In total, we included 19 articles that analyzed 5 dietary patterns The study showed that a diet high in inflammation-promoting foods significantly raised the likelihood of periodontitis (OR = 1.39, 95% CI, 1.09-1.77), in contrast, dietary patterns like the mediterranean diet (OR = 0.96, 95% CI, 0.94-0.98), plant-based diet (OR = 0.92, 95% CI, 0.86-0.98), or dairy-rich diet (OR = 0.76, 95% CI, 0.66-0.87) lowered the risk of periodontitis. The analysis revealed no statistically significant association between a western diet (OR = 1.07; 95% CI, 0.86-1.33) and the risk of periodontitis.</p><p><strong>Conclusions: </strong>As dietary diversity and complexity continue to expand, there has been a concomitant increase in the prevalence of periodontal disease. This study has identified specific dietary patterns associated with the risk of periodontitis, particularly highlighting the heightened risk linked to pro-inflammatory diets. These findings emphasize the importance of implementing targeted dietary practices to reduce the incidence of this condition.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"43"},"PeriodicalIF":3.1,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142920976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative evaluation of intraoral scanners and a spectrophotometer for percent correct shade identification in clinical dentistry.","authors":"Sascha Hein, Julian Nold, Matthias Masannek, Stephen Westland, Benedikt C Spies, Karl Thomas Wrbas","doi":"10.1007/s00784-024-06124-0","DOIUrl":"10.1007/s00784-024-06124-0","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to assess the percent correct shade identification of four intraoral scanners (IOS) and a spectrophotometer, focusing on how reliably each device selects the correct tooth shade compared to a visual observer's selection. The research question addresses how much clinicians can trust the device-selected shade without visual verification.</p><p><strong>Materials and methods: </strong>Sixteen participants with natural, unrestored teeth were included. The teeth evaluated were tooth 21 (left maxillary central incisor), tooth 23 (left maxillary canine), and tooth 26 (first left maxillary molar). Tooth color was measured using four IOS devices and the Vita Easyshade V in three regions: incisal, middle, and cervical. The nearest 3D Master shade selected by each device was compared to the visual observer's selection. The percent exact match, acceptable match (> 1.2, ≤ 2.7 ∆E_ab), and mismatch type A (< 2.7, ≤ 5.4 ∆E_ab) were calculated. Statistical analysis was performed using a chi-square test with a 95% confidence level.</p><p><strong>Results: </strong>The overall clinical pass rate was highest for Carestream (78.2%), followed by Easyshade (63.5%), Primescan (51.2%), Trios (39.5%), and Medit (31.3%). Carestream also recorded the highest rate of mismatch type A (47.7%). Significant differences between devices were observed for all categories (p < 0.05).</p><p><strong>Conclusions: </strong>Carestream demonstrated the highest overall clinical pass rate, while Medit exhibited the lowest. The study highlights the variability between devices in shade matching performance.</p><p><strong>Clinical relevance: </strong>This study highlights the importance of considering device performance when relying on IOS or spectrophotometers for shade selection without visual assessment, as the reliability can vary significantly across devices.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"39"},"PeriodicalIF":3.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11693619/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The determination of patient-based experiences with smartphone-based report of awake bruxism using a diary.","authors":"Anna Colonna, Daniele Manfredini, Alessandro Bracci, Ovidiu Ionut Saracutu, Marco Ferrari, Frank Lobbezoo","doi":"10.1007/s00784-024-06114-2","DOIUrl":"10.1007/s00784-024-06114-2","url":null,"abstract":"<p><strong>Objectives: </strong>In recent years, a smartphone-based ecological momentary assessment (EMA) approach for assessing awake bruxism (AB) has attracted growing interest, both in clinical and research settings. The present study was designed to investigate subjects' experience using an EMA-based smartphone application to detect factors that could hamper or facilitate its use for clinical and research purposes.</p><p><strong>Materials and methods: </strong>Thirty-two patients with temporomandibular disorders (TMDs) pain (14 males, 18 females; mean age 28.3 ± 12.1 years) were recruited at the Orofacial Pain Unit of the University of Siena, Siena, Italy. They were monitored for one week to collect data on their AB behaviors. Time investment, feelings, encountered difficulties, and reasons for not using the app were assessed in a diary with 5-point Likert scales. Descriptive analysis of quantitative data was assessed, and content analysis of textual data was performed.</p><p><strong>Results: </strong>Quantitative data showed a good experience with the app (median of 4). The main motivation to use the EMA-based smartphone application was to gain insight into their own AB behaviours. The most negative experience was the short time window available to answer to the alert.</p><p><strong>Conclusion: </strong>The EMA-based smartphone application was well accepted for multiple day evaluation.</p><p><strong>Clinical relevance: </strong>These results open up important clinical scenarios for AB evaluation as well as the possibility to carry out large-scale studies on general population samples and/or on selected subpopulations.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"40"},"PeriodicalIF":3.1,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142914029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between life's essential 8 and periodontitis: evidence from NHANES 2009-2014.","authors":"Zhikang Wang, Rui Pu, Jing Zhang, Ying Wang, Guoli Yang","doi":"10.1007/s00784-024-06117-z","DOIUrl":"10.1007/s00784-024-06117-z","url":null,"abstract":"<p><strong>Objectives: </strong>To explore the relationship between Life's Essential 8 (LE-8) and periodontitis, specifically focusing on identifying the specific factors within LE-8 significantly linked to periodontitis.</p><p><strong>Materials and methods: </strong>This cross-sectional study utilized data from the National Health and Nutrition Examination Survey (2009-2014), involving 8160 participants with available LE-8 metrics and periodontal examination results. The LE-8 metrics, encompassing diet, physical activity, nicotine exposure, sleep health, body mass index, blood liquids, blood glucose, and blood pressure were collected for analysis. Periodontitis diagnosis followed CDC-AAP guidelines.</p><p><strong>Results: </strong>4049 subjects with periodontitis (mean age, 54.80 years; 57.93% male) and 4111 subjects without periodontitis (mean age, 48.66 years; 42.61% male) were included in this study. Periodontitis subjects had lower total LE-8 scores (64.62 [63.94, 65.30]) than periodontitis-free subjects (71.34 [70.65, 72.03]). The risk of periodontitis risk significantly decreased with increasing LE-8 score. Specific factors within LE-8, including avoidance of nicotine (Adjusted OR = 0.90 [0.88, 0.92]), healthy sleep (Adjusted OR = 0.95 [0.92, 0.99]), and healthy levels of blood glucose (Adjusted OR = 0.94 [0.90, 0.98]) were negatively associated with periodontitis presences.</p><p><strong>Conclusions: </strong>Higher scores in life's essential 8 metrics, particularly in nicotine exposure, sleep health, and blood glucose, may benefit periodontal health.</p><p><strong>Clinical relevance: </strong>Adopting a healthy lifestyle reduces the risk of periodontitis. Avoiding smoking, sufficient sleep, and stable blood glucose are linked to lower periodontitis risk. Healthcare professionals should advise individuals with lower life's essential 8 scores to prioritize oral care.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"37"},"PeriodicalIF":3.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Constructing two bifunctional tooth-targeting antimicrobial peptides for caries management: an in vitro study.","authors":"Pei Hu, Pan Chen, Gengyu Zhou, Jingyu Hu, Surong Chen, Yingjie Li, Yan Yang, Jingzhi Ma","doi":"10.1007/s00784-024-06139-7","DOIUrl":"10.1007/s00784-024-06139-7","url":null,"abstract":"<p><strong>Objectives: </strong>Caries is a significant public health challenge. Herein, novel tooth-targeting antimicrobial peptides (HABPs@AMPs) were developed by combining the antimicrobial peptide DJK-5 with hydroxyapatite (HA) binding peptides, providing a potential new strategy for caries management.</p><p><strong>Materials and methods: </strong>The minimal inhibitory concentration (MIC₁₀₀) and minimal biofilm inhibitory concentration (MBIC₁₀₀) values of HABPs@AMPs were determined via micro-broth dilution and crystal violet staining. The affinities of the peptides for HA were measured by mass depletion, and the abilities of peptides to inhibit Streptococcus mutans (S. mutans) biofilm formation and kill 3-day-old S. mutans biofilms were evaluated in HA disk and tooth slice biofilm models through confocal laser scanning microscopy. Biocompatibility with human gingival fibroblasts was evaluated via CCK8 assays.</p><p><strong>Results: </strong>The best performing peptides, DJK-5@SVA and SVA@DJK-5 exhibited MIC₁₀₀ and MBIC₁₀₀ values of 31.25 µg/mL, similar to DJK-5. DJK-5@linker2@YSL had the highest affinity for HA, followed by YSL@DJK-5, DJK-5@linker1@YSL, and DJK-5@SVA. Moreover, the biofilms on HABPs@DJK-5 coated surfaces had more dead bacteria by volume than those in the DJK-5 and SVA groups (p < 0.05). DJK-5@SVA outperformed SVA@DJK-5 and DJK-5 in killing 3-day-old S. mutans biofilms (p < 0.05). With the exception of established biofilms on tooth slices, DJK-5@SVA exhibited greater killing efficiency in the bottom half of the biofilms than in the top half. The CCK-8 assay results confirmed peptides' biocompatibility.</p><p><strong>Conclusions: </strong>DJK-5@SVA with good affinity for HA, has excellent biocompatibility and efficacy against S. mutans biofilms.</p><p><strong>Clinical relevance: </strong>HABPs@AMPs with effective inhibitory effects on the growth of S. mutans and biofilm formation, contributing to intraoral targeted application AMPs and providing a new strategy for caries management.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"36"},"PeriodicalIF":3.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909406","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"When trauma bites back: a systematic review on direct orofacial macrotrauma and temporomandibular disorders.","authors":"Loreine M L Helmer, Sebastiaan W R Dalmeijer, Michail Koutris, Ralph de Vries, Leander Dubois, Jan de Lange, Frank Lobbezoo","doi":"10.1007/s00784-024-06095-2","DOIUrl":"10.1007/s00784-024-06095-2","url":null,"abstract":"<p><strong>Objectives: </strong>Temporomandibular disorders (TMD) are musculoskeletal conditions with a multifactorial aetiology. The predictive role of direct orofacial macrotrauma in the development of TMD is considered controversial. This systematic review aims to elucidate the association between direct orofacial macrotrauma and TMD, and to identify potential factors involved in this relationship.</p><p><strong>Materials and methods: </strong>A comprehensive literature search of PubMed, Embase, and Web of Science databases up to November 1, 2023, was performed in collaboration with a medical information specialist, identifying 2,047 unique studies. Of these, 139 met the inclusion criteria of this investigation.</p><p><strong>Results: </strong>Our synthesis of the literature indicates a consistent association between TMD and direct orofacial macrotrauma in adults, while this relationship appears less defined in paediatric and adolescent populations. The association shows robustness across various TMD diagnoses and trauma locations, remaining not only immediately following the direct orofacial macrotrauma but also after long time, despite other interventions. These outcomes could be due to the physical effect of the trauma, but they might be associated with the psychosocial effect of the trauma as well.</p><p><strong>Conclusions: </strong>The evidence supports a robust, but complex, association between direct orofacial macrotrauma and TMD.</p><p><strong>Clinical relevance: </strong>This finding underscores the importance of considering both physical and psychosocial sequelae of trauma in the clinical management of direct orofacial macrotrauma and TMD.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"35"},"PeriodicalIF":3.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective, randomized clinical trial evaluating the clinical performance of a new universal adhesive in Class I and Class II restorations at 1 year.","authors":"Jorge Perdigão, Hooi Pin Chew, Ignatius K Lee, Kacie Woodis, Brian Hatch","doi":"10.1007/s00784-024-06121-3","DOIUrl":"10.1007/s00784-024-06121-3","url":null,"abstract":"<p><strong>Objective: </strong>This randomized controlled trial compared the 1-year clinical efficacy of Scotchbond Universal Adhesive Plus (SBU+) with that of its predecessor Scotchbond Universal Adhesive (SBU) to restore Class I and Class II preparations using the self-etch strategy in adult patients.</p><p><strong>Materials and methods: </strong>Fifty-one subjects participated in this study. Two posterior teeth in each subject were randomized to a restoration with SBU+ or to a restoration with SBU (control) using the self-etch strategy. Teeth were restored with Filtek Universal Restorative. Restorations were evaluated at baseline, 6 months and 1 year using the FDI criteria. The Wilcoxon signed-rank test was used to compare outcomes.</p><p><strong>Results: </strong>No restorations were graded as \"Insufficient/Unsatisfactory\" or \"Poor\" for any of the FDI criteria at the baseline, 6-month, or 1-year visits. At 1 year the retention rate was 100% for both SBU+ and SBU. For fracture of the restorative material 42/44 SBU+ restorations (95%) and 44/44 SBU restorations (100%) were graded \"Excellent/Very Good\" (p > 0.05). All restorations were clinically acceptable for marginal adaptation at 1 year with no statistical differences between the two adhesive materials. There were no recurrent caries lesions at the 1-year visit.</p><p><strong>Conclusions: </strong>The clinical efficacy of the SBU+ at 1-year was not different to that of its predecessor SBU in Class I and Class II restorations of adult patients using the self-etch strategy.</p><p><strong>Clinical relevance: </strong>The two dental adhesives used in this clinical trial showed excellent results in posterior restorations at 1 year without using a separate phosphoric etching step.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"38"},"PeriodicalIF":3.1,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142909422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}