Clinical Oral Investigations最新文献

{"title":"Final incisor position across sagittal and vertical skeletal patterns in Chinese orthodontic patients with acceptable posttreatment profiles.","authors":"Zihan Meng, Ting Ma, Erkang Tian, Jiaxin Yang, Qingchen Feng, Chaoran Xue, Xianglong Han, Juan Li","doi":"10.1007/s00784-026-07131-z","DOIUrl":"10.1007/s00784-026-07131-z","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to describe the distribution of final incisor position in orthodontically treated Chinese patients with acceptable profile outcomes across different sagittal and vertical skeletal patterns.</p><p><strong>Materials and methods: </strong>Posttreatment lateral cephalograms of 727 patients aged ≥ 16 years were analyzed. Patients were stratified according to pretreatment sagittal skeletal classification (Class I, II, III) and vertical skeletal pattern (low, normal, high angle). Incisor inclination, anteroposterior position (AP position) and vertical level were compared among groups.</p><p><strong>Results: </strong>Incisor inclination differed significantly across both sagittal and vertical skeletal patterns, with angular differences reaching 12.09° (d > 1.0). Sagittal skeletal classification exerted a dominant influence on maxillary incisor AP position, with intergroup differences in U1-NA exceeding 2.3 mm (d > 1.14), whereas mandibular incisors demonstrated limited AP displacement (< 2 mm) despite marked angular variation. Pogonion-referenced indices (U1-Pog, L1-Pog) differed significantly across sagittal and vertical patterns (P < 0.001), reflecting systematic variation in incisor position relative to facial projection.</p><p><strong>Conclusions: </strong>Final incisor position did not converge toward a single common reference. Incisor inclination varied with both sagittal and vertical morphology. Anteroposterior position was associated mainly with sagittal pattern, especially in the maxillary incisors, whereas mandibular incisors showed limited anteroposterior displacement. Chin-referenced measurements provided additional information on final incisor position in relation to facial projection. These findings provide descriptive skeletal-pattern-conditioned reference distributions, rather than universal reference values or evidence-based optimal treatment targets.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ethical and regulatory aspects of facial scanning in dentistry: a scoping review.","authors":"Thanatchaporn Jindanil, Pierre Lahoud, Maxime Ducret, Raphael Richert, Jennifer K Wagner, Reinhilde Jacobs","doi":"10.1007/s00784-026-07132-y","DOIUrl":"10.1007/s00784-026-07132-y","url":null,"abstract":"<p><strong>Objectives: </strong>To provide an overview of facial scanners and scanning applications used in dentistry, focusing on clinical validation, certification status, and to identify ethical and regulatory concerns.</p><p><strong>Materials and methods: </strong>A literature search was performed with eligibility criteria that included studies in dentistry that used at least one facial scanner or smartphone scanning application in human facial region in any language. Scanners and applications identified from literature and International Dental Show 2025 were manually noted, and subsequently searched for detailed certification (medical, general, others) and technical information. Furthermore, studies explicitly/implicitly mention/discuss ethical and/or regulatory concerns were included.</p><p><strong>Results: </strong>Ninety-five scanners and 23 smartphone-based applications were identified, of which 90 scanners and all applications were clinically validated. Six scanners (6%, FusionFaceScanner, Carestream CS9600, Planmeca ProFace, Planmeca ProMax 3D Mid, Planmeca ProMax 3D ProFace, Planmeca Viso G7) were Medical Device Regulation-certified, 49% held other certifications, and 51% had unverifiable certification status. Among 19,789 records, six scientific studies discussed ethical concerns, including ethical approval, informed consent, privacy, accuracy, and medical regulatory obligations.</p><p><strong>Conclusion: </strong>Despite validation, publicly accessible, verifiable medical-related certification remained limited among the identified scanners, highlighting that ethical and regulatory considerations are underreported in the scientific literature rather than absent from clinical practice. Informed consent, data privacy, accuracy, and medical device compliance were addressed in the included studies.</p><p><strong>Clinical relevance: </strong>As facial scans provide comprehensive information for esthetic- and facial-driven treatment planning, the findings of this study highlight the need for practitioners and researchers to remain cautious regarding device safety, regulatory compliance, and technological limitations.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13597567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical performance of glass hybrid and short fiber-reinforced composite restorations in MIH-affected molars: A 60-month split-mouth randomized controlled trial.","authors":"Nur Kodaman Dokumacıgil, Betül Şen Yavuz, Remziye Kaya, Betül Kargül","doi":"10.1007/s00784-026-07145-7","DOIUrl":"10.1007/s00784-026-07145-7","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to compare the 60-month clinical performance of glass hybrid (GH) and short fiber-reinforced composite (SFRC)-supported microhybrid composite restorations placed in MIH-affected first permanent molars following selective caries removal (SCR).</p><p><strong>Materials and methods: </strong>Thirty-one children (18 girls, 13 boys; 6-12 years) with MIH and at least two fully erupted first permanent molars exhibiting moderate-to-severe lesions (MIH-TNI scores 2 and 4) were enrolled. Following SCR, 62 molars were restored using a randomized split-mouth design. In each participant, one molar received a GH restoration (Equia Forte^® HT), whereas the other selected molar was restored with an SFRC material (EverX Flow™) covered with a microhybrid composite resin (G-Aenial^® Posterior). Clinical evaluations were performed at baseline and 6, 12, 24, 36, and 60 months using modified United States Public Health Service (USPHS) criteria.</p><p><strong>Results: </strong>Clinical performance deteriorated significantly over time for both materials (p < 0.001). GEE analysis showed no significant independent effect of material type on any modified USPHS criterion (p > 0.05), while time significantly affected retention, marginal adaptation, postoperative sensitivity, and secondary caries (p < 0.001). Kaplan-Meier analysis demonstrated significantly higher survival rates for SFRC-supported microhybrid composite than for GH restorations at 60-month (75.5% vs. 59.2%; p = 0.002).</p><p><strong>Conclusions: </strong>Both GH and SFRC-supported microhybrid composite restorations provided clinically acceptable long-term outcomes in MIH-affected molars after SCR. Although clinical performance per modified USPHS criteria was comparable, SFRC-supported microhybrid composite restorations demonstrated superior long-term survival.</p><p><strong>Clinical relevance: </strong>When long-term durability is a primary consideration, SFRC-supported microhybrid composite restorations may be preferred for the restorative management of MIH-affected molars.</p><p><strong>Clinical trial registration: </strong>ClinicalTrials.gov, NCT07733804.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The German S3-level guideline for the diagnosis and management of rare dental disorders.","authors":"Helena Dujic, Katharina Bücher, Ina Manuela Schüler, Peter Schmidt, Susann Hertel, Julia Timpel, Anahita Jablonski-Momeni, Reinhard Schilke, Ines Kapferer-Seebacher, Johannes Zschocke, Anja Liebermann, Jan Frederik Güth, Daniel Edelhoff, Roswitha Heinrich-Weltzien, Jan Kühnisch","doi":"10.1007/s00784-026-07142-w","DOIUrl":"10.1007/s00784-026-07142-w","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this German S3-level guideline project was to develop evidence-based recommendations to support professionals in the diagnosis and management of individuals with rare dental disorders. The research question was which form of dental care should be part of an age-related, long-term treatment for individuals affected by amelogenesis imperfecta, dentinogenesis imperfecta, ectodermal dysplasia, X-linked hypophosphatemia, hypophosphatasia or rare periodontal disorders.</p><p><strong>Materials and methods: </strong>The guideline development combines a systematic search of the literature, expert input from multiple disciplines and a structured consensus process. In addition to phrasing recommendations on clinical, radiological and genetic diagnostics, much emphasis has been placed on the development of disease-specific treatment recommendations. This article presents a summary of the German guideline.</p><p><strong>Results: </strong>A total of 41 evidence- and consensus-based recommendations covering interdisciplinary collaboration, diagnostics, preventive care, restorative and prosthetic treatment, and orthodontic and surgical interventions were developed. The recommendations emphasise the importance of tailoring dental care to the individual patient's needs.</p><p><strong>Conclusions: </strong>For the first time, an evidence-based guideline is available for the dental management of individuals affected by rare dental disorders. The guideline provides practical guidance and highlights the need for interdisciplinary management approaches. Furthermore, the guideline establishes a foundation for standardised, evidence-based dental care.</p><p><strong>Clinical relevance: </strong>This guideline is expected to improve oral health outcomes and quality of life in this vulnerable patient group. Although developed in Germany, it may inform adoption or adaptation internationally, thereby fostering harmonised standards of care in different healthcare systems.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13597538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149024064","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of continuous chelation on the push-out bond strength of epoxy resin and calcium silicate sealers in oval root canals.","authors":"Rebecca R G Frota, Michael Solomonov, Gustavo De-Deus, Emmanuel J N L Silva, Felipe G Belladonna, Joe Ben-Itzhak, Erick M Souza, Diogo S Oliveira, Marco A Versiani","doi":"10.1007/s00784-026-07138-6","DOIUrl":"10.1007/s00784-026-07138-6","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the push-out bond strength (POBS) of AH Plus and TotalFill BC Sealer in long oval canals prepared with the Self-Adjusting File Infinitum (SAF Infinitum) system.</p><p><strong>Materials and methods: </strong>Thirty mandibular canines with long oval canals, selected by micro-CT analysis and anatomically matched, were assigned to three irrigation-protocol groups (n = 10): 2.5% NaOCl (4 min, 4 mL/min); 2.5% NaOCl/HEDP (4 min, 2 mL/min); and 2.5% NaOCl/HEDP (2 min, 2 mL/min). Each group was subdivided by sealer (AH Plus or TotalFill BC Sealer, n = 5) and filled using the single-cone technique. Roots were sectioned into coronal, middle, and apical slices for POBS testing and failure mode analysis. POBS was analyzed using a Gamma generalized linear mixed-effects model with a log link and tooth as a random intercept, followed by Bonferroni-adjusted pairwise comparisons (α = 0.05).</p><p><strong>Results: </strong>Neither irrigation protocol (P = 0.879) nor sealer (P = 0.769) significantly affected POBS, and no two- or three-way interactions were significant (all P > 0.7). In contrast, POBS differed significantly across root thirds (P < 0.001), with higher values in the apical than in the coronal (P = 0.001) and middle thirds (P < 0.001), and higher in the coronal than in the middle third (P = 0.005). Adhesive failure at the sealer-gutta-percha interface predominated overall (80% AH Plus, 93% TotalFill BC) and was universal in the middle third.</p><p><strong>Conclusions: </strong>In long oval canals prepared with SAF Infinitum, POBS differed significantly according to root third but not according to sealer type or irrigation protocol.</p><p><strong>Clinical relevance: </strong>When the SAF Infinitum system is used with a single-cone filling technique, short-term POBS does not appear to differ according to the irrigation protocol or sealer type under the conditions tested. Sealer and irrigation choices may therefore be guided by other biological and clinical considerations rather than by short-term push-out bond strength alone.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasonographic evaluation of masseter and temporalis muscle thickness and elasticity in individuals with bruxism and bruxism-related myogenous temporomandibular disorders.","authors":"Gözde Özcan, Meryem Kaygısız Yiğit, Meryem Etöz","doi":"10.1007/s00784-026-07140-y","DOIUrl":"10.1007/s00784-026-07140-y","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the thickness and elasticity characteristics of the masseter and temporalis muscles in individuals with probable bruxism and bruxism-related myogenous temporomandibular disorders (TMD) using ultrasonography and ultrasonographic elastography.</p><p><strong>Materials and methods: </strong>This comparative cross-sectional study included 60 patients and 30 healthy controls. Patients were divided into probable bruxism only (Group 1, n = 30) and probable bruxism with myogenous TMD (Group 2, n = 30). Bilateral masseter and temporalis muscle thickness was measured at rest and during maximum contraction. Strain elastography was performed using a tissue phantom reference. Intergroup comparisons were performed using one-way ANOVA with Bonferroni correction.</p><p><strong>Results: </strong>Group 2 demonstrated significantly greater masseter muscle thickness than controls and Group 1, particularly during contraction (p < 0.05). Masseter elasticity ratios were significantly higher in both patient groups than controls, with the highest values in Group 2. During maximum contraction, masseter elasticity ratios were 2.98 ± 1.24 in Group 1, 3.93 ± 2.23 in Group 2, and 2.29 ± 0.87 in controls. Temporalis muscle elasticity values were also significantly increased in Group 2.</p><p><strong>Conclusions: </strong>Individuals with probable bruxism and bruxism-related myogenous TMD demonstrated differences in masticatory muscle thickness and stiffness, particularly during maximum contraction. Ultrasonography and ultrasonographic elastography may provide complementary information regarding masticatory muscle characteristics and hyperactivity. Given the unadjusted analyses, these findings should be interpreted cautiously.</p><p><strong>Clinical relevance: </strong>Ultrasonography and ultrasonographic elastography may provide useful adjunctive, radiation-free imaging methods for evaluating masticatory muscle alterations in individuals with probable bruxism and bruxism-related myogenous TMD.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016182","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cystic fibrosis and its impact on the oral cavity and dental treatments - a scoping review.","authors":"Inês Lopes Cardoso, Maria Inês Guimarães, Elisa Le Cozic, Fernanda Leal","doi":"10.1007/s00784-026-07137-7","DOIUrl":"10.1007/s00784-026-07137-7","url":null,"abstract":"<p><strong>Objectives: </strong>Cystic fibrosis is an autosomal recessive disease caused by mutations in the CFTR gene, mainly affecting the respiratory and digestive systems. Advances in diagnosis and treatment have increased life expectancy, making cystic fibrosis a chronic condition requiring long-term multidisciplinary care. Consequently, oral health has gained importance, as disease manifestations and prolonged therapies may influence the oral cavity and dental management. This review aimed to analyse the available scientific evidence regarding the impact of cystic fibrosis on oral health and dental treatments. The guiding research question was: What is the impact of cystic fibrosis on the oral cavity and dental treatments?</p><p><strong>Methodology: </strong>A literature search was conducted in PubMed, Scopus, Web of Science and Cochrane Library using the keywords: cystic fibrosis, oral health, and dental treatment. After applying inclusion and exclusion criteria, 22 articles were selected.</p><p><strong>Results: </strong>Although findings remain heterogeneous, the included studies suggest that cystic fibrosis is associated with specific oral changes. In children, a lower prevalence of dental caries was frequently reported, often linked to prolonged antibiotic use. In adults, studies indicated a higher prevalence of untreated caries and poorer oral health status. Developmental enamel defects and salivary alterations were also commonly observed.</p><p><strong>Conclusions: </strong>Cystic fibrosis may significantly affect oral health, highlighting the need for individualized dental care focused on prevention, regular monitoring, and adaptation to each patient's specific needs.</p><p><strong>Clinical relevance: </strong>Individualized preventive and therapeutic strategies, regular monitoring, and integration of dental professionals into multidisciplinary teams may improve oral health outcomes, treatment adherence, and quality of life.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of 3D superimposition software on intraoral scanner accuracy and monitoring outcome.","authors":"Albert Mehl, Jenny Buhl, Andreas Ender","doi":"10.1007/s00784-026-07136-8","DOIUrl":"10.1007/s00784-026-07136-8","url":null,"abstract":"<p><strong>Objectives: </strong>To determine whether 3D superimposition software (\"Apps\") systematically affects 3D deviation outcomes derived from intraoral scanner (IOS) data, using two quantile‑range accuracy metrics (Q90_Q10_half and Q95_Q05_half).</p><p><strong>Materials and methods: </strong>Two jaw‑sized reference models were digitized with a high‑resolution optical scanner (ATOS III) to generate reference STL meshes (REF_STL). Five IOS devices acquired ten scans per device and per jaw model, exported as STL meshes (IMP_STL): Emerald Green, iTero 5D, Medit i900, Primescan, and Trios 5. Each IMP_STL was trimmed (1 mm above gingival line) and superimposed to REF_STL in four Apps: commercial industrial software: Geomagic Control X and GOM Inspect, and open dentistry-focused software Medit Design (Compare) and Dentexion; resulting in total to N = 400 superimpositions. For each superimposition, Q90_Q10_half and Q95_Q05_half values were computed from point-wise signed surface distances. A linear mixed‑effects model tested factor App as fixed effect with random intercepts for factors Device and Jaw, followed by Bonferroni‑adjusted pairwise comparisons (α = 0.05).</p><p><strong>Results: </strong>App significantly influenced Q90_Q10_half (p < 0.01) and Q95_Q05_half (p < 0.001). Control X yielded higher adjusted means than Dentexion and Compare for Q90_Q10_half (both p < 0.01), while Dentexion, GOM, and Compare did not differ. For Q95_Q05_half, Control X exceeded all other Apps (all p < 0.01). Notably, IOS rankings were stable across Apps, indicating that software altered magnitude but not relative ordering.</p><p><strong>Conclusions: </strong>Evaluation software is a significant source of variability in 3D deviation metrics; Control X produced consistently higher (more conservative) quantile‑range values, particularly for Q95_Q05_half.</p><p><strong>Clinical relevance: </strong>Inter‑study comparisons in digital accuracy research should report the evaluation software and settings. Dentistry‑focused Apps (e.g., with automated tooth segmentation) may reduce operator‑dependent effects and facilitate clinically applicable monitoring.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588928/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of two biomimetic remineralizing systems on artificially demineralized enamel: Assessment of mineral recovery and orthodontic bracket bond strength.","authors":"Ascensión Vicente, Antonio J Ortiz-Ruiz, Clara Serna-Muñoz, Inmaculada Cabello, Yolanda Martínez-Beneyto","doi":"10.1007/s00784-026-07130-0","DOIUrl":"10.1007/s00784-026-07130-0","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the effect of two remineralizing systems (Regenerate™ and Orthocare™) on the mineral recovery of demineralized enamel and on the shear bond strength (SBS) of brackets.</p><p><strong>Methods: </strong>180 bovine teeth were divided into four groups: 1)Intact enamel, 2)Demineralized enamel, 3)Demineralized enamel/Regenerate™, and 4)Demineralized enamel treated/Orthocare™. Groups 2 to 4 were demineralized. All samples were brushed three times daily; groups 1 and 2 without toothpaste, and groups 3 and 4 were treated with Regenerate™ or Orthocare™. Outcomes were assessed by SBS, adhesive remnant area, field-emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), Raman spectroscopy, surface microhardness, and micro-computed tomography (micro-CT). Parametric or non-parametric tests according to data distribution (α = 0.05).</p><p><strong>Results: </strong>Demineralized enamel showed significantly lower SBS, adhesive remnant, surface microhardness, mineral density, calcium and phosphorus content, and phosphate-related Raman parameters than intact enamel (p < 0.05). FE-SEM revealed increased porosity. Neither remineralizing system significantly restored SBS compared with untreated demineralized enamel. However, both treatments promoted partial enamel remineralization, improved calcium (Ca) and phosphorus (P) levels (p < 0.001), increasing surface microhardness and mineral density (p < 0.05). Raman showed greater recovery of phosphate (I₉₆₀) and carbonate (I₁₀₇₀) peaks in the Regenerate™ group, indicating better mineralization and crystallinity recovery than Orthocare™.</p><p><strong>Conclusions: </strong>Both agents partially remineralized enamel without fully restoring sound enamel properties. Regenerate™ demonstrated better mineral recovery than Orthocare™. However, the newly formed hydroxyapatite appeared immature, and bond strength was not significantly improved compared with demineralized enamel.</p><p><strong>Clinical relevance: </strong>Remineralizing agents may improve demineralized enamel before orthodontic bonding without significantly affecting bracket bond strength.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149001393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Developmental enamel defects and hypomineralized second primary molars among preschool children in Kuwait: associations with caries severity and oral health-related quality of life.","authors":"Abrar Alanzi, Sahar Behzadi, Jagan Baskaradoss, Aishah Alsumait","doi":"10.1007/s00784-026-07139-5","DOIUrl":"10.1007/s00784-026-07139-5","url":null,"abstract":"","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}