Clinical Oral Investigations最新文献

{"title":"Brief orofacial myofunctional therapy and tongue pressure as prediction factors for open bite correction: a randomized clinical trial.","authors":"Thagid Yasmin Leal, Daniela Garib, Henrique Eto, Raquel Rosa, Felicia Miranda, Asenate Soares, Ana Paula Fukushiro, Giédre Berretin-Felix","doi":"10.1007/s00784-025-06483-2","DOIUrl":"10.1007/s00784-025-06483-2","url":null,"abstract":"<p><strong>Objectives: </strong>To compare changes in tongue pressure during anterior open bite (AOB) treatment using a fixed palatal crib (PC) alone versus PC combined with brief orofacial myofunctional therapy (OMT), and to determine whether these changes predict overbite correction.</p><p><strong>Materials and methods: </strong>Thirty-two patients were divided into two groups: the PC group received a fixed palatal crib alone, while the PC-OMT group received PC plus weekly OMT sessions for the first two months. Lateral cephalometric radiographs and tongue pressure measurements using the Iowa Oral Performance Instrument (IOPI) were collected at baseline (T1) and after open bite correction or 12 months later when the appliance was removed (T2). Primary outcomes included changes in tongue pressure and overbite. Analysis of covariance (ANCOVA) controlled for initial open bite severity (p < 0.05). Linear regression analyzed the relationship between tongue pressure changes and overbite correction.</p><p><strong>Results: </strong>Each group included 16 patients (PC: 3 males, 13 females; mean age 8.65± 0.93 years; PC-OMT: 9 males, 7 females; mean age 7.97 ± 1.00 years). Both groups showed similar overbite improvements. Tongue pressure increased in all variables across groups; however, swallowing pressure increased significantly less in the PC-OMT group. Changes in tongue pressure were not associated with overbite correction.</p><p><strong>Conclusions: </strong>Treatment with PC alone or combined with brief OMT yielded comparable overbite corrections. The addition of OMT moderated tongue pressure increases during swallowing. Changes in tongue pressure did not predict open bite correction in mixed dentition.</p><p><strong>Clinical relevance: </strong>Brief OMT combined with PC may reduce atypical swallowing post-crib removal, supporting long-term treatment stability.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"407"},"PeriodicalIF":3.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical, radiographic and molecular efficacy of LLLT along with minimally invasive flaps in regeneration of periodontal intrabony defects: a randomized controlled clinical trial.","authors":"Prakash Psg, Kavitha Sanjeev, Sangeetha Subramanian, Abirami Thanigaimalai, Devapriya Appukuttan","doi":"10.1007/s00784-025-06493-0","DOIUrl":"10.1007/s00784-025-06493-0","url":null,"abstract":"<p><strong>Aim: </strong>The current study evaluates the effectiveness of low level laser therapy (LLLT) in intra-bony defect regeneration, by comparing the clinical, radiographic and molecular parameters between periodontitis patients with intra-bony defects treated with simplified papilla preservation flap(SPPF) alone and SPPF with adjunctive use of LLLT.</p><p><strong>Methodology: </strong>The current study is a randomized controlled clinical trial involving 64 sites, 32 sites treated with SPPF- control group and 32 sites treated with SPPF and adjunctive use of LLLT(SPPF + LLLT)- test group. Clinical parameters were evaluated at baseline, 6 months and 1 year post surgery. Radiographic defect depths were evaluated at baseline and 1 year post surgery. Molecular parameters- RUNX2, BMP-2, osteopontin and COL-1 are evaluated at 3, 7 and 14 days. The results were statistically analysed.</p><p><strong>Results: </strong>There was a statistically significant reduction in clinical parameters and radiographic defect depth seen in test group at the 6 months and one year post surgery when compared with control group (P < 0.05). In addition, the total number of sites with probing pocket depth more than 4 mm has reduced significantly in test group when compared to control group at 6 months and one year. RUNX2, BMP-2 and COL - 1 were significantly elevated in test group.</p><p><strong>Conclusion: </strong>The current study reports a significant improvement of clinical, radiographic and molecular parameters of intra-bony defect sites in periodontitis patients treated with SPPF + LLLT when compared to SPPF alone.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"404"},"PeriodicalIF":3.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring GPT-4o's multimodal reasoning capabilities with panoramic radiograph: the role of prompt engineering.","authors":"Yu-Tao Xiong, Wen-Jun Lian, Ya-Nan Sun, Wei Liu, Ji-Xiang Guo, Wei Tang, Chang Liu","doi":"10.1007/s00784-025-06498-9","DOIUrl":"10.1007/s00784-025-06498-9","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to evaluate GPT-4o's multimodal reasoning ability to review panoramic radiograph (PR) and verify its radiologic findings, while exploring the role of prompt engineering in enhancing its performance.</p><p><strong>Methods: </strong>The study included 230 PRs from West China Hospital of Stomatology in 2024, which were interpreted to generate the PR findings. A total of 300 instances of interpretation errors, were manually inserted into the PR findings. The ablation study was conducted to assess whether GPT-4o can perform reasoning on PR under a zero-shot prompt. Prompt engineering was employed to enhance the reasoning capabilities of GPT-4o in identifying interpretation errors with PRs. The prompt strategies included chain-of-thought, self-consistency, in-context learning, multimodal in-context learning, and their systematic integration into a meta-prompt. Recall, accuracy, and F1 score were employed to evaluate the outputs. Subsequently, the localization capability of GPT-4o and its influence on reasoning capability were evaluated.</p><p><strong>Results: </strong>In the ablation study, GPT-4o's recall increased significantly from 2.67 to 43.33% upon acquiring PRs (P < 0.001). GPT-4o with the meta prompt demonstrated improvements in recall (43.33% vs. 52.67%, P = 0.022), accuracy (39.95% vs. 68.75%, P < 0.001), and F1 score (0.42 vs. 0.60, P < 0.001) compared to the zero-shot prompt and other prompt strategies. The localization accuracy of GPT-4o was 45.67% (137 out of 300, 95% CI: 40.00 to 51.34). A significant correlation was observed between its localization accuracy and reasoning capability under the meta prompt (φ coefficient = 0.33, p < 0.001). The model's recall increased by 5.49% (P = 0.031) by providing accurate localization cues within the meta prompt.</p><p><strong>Conclusions: </strong>GPT-4o demonstrated a certain degree of multimodal capability for PR, with performance enhancement through prompt engineering. Nevertheless, its performance remains inadequate for clinical requirements. Future efforts will be necessary to identify additional factors influencing the model's reasoning capability or to develop more advanced models.</p><p><strong>Clinical relevance: </strong>Evaluating GPT-4o's capability to interpret and reason through PRs and exploring potential methods to enhance its performance before clinical application in assisting radiological assessments.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"405"},"PeriodicalIF":3.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of maxillofacial trauma in patients with alcohol use disorder : a cross-sectional study on awareness, practices and gaps.","authors":"Elavenil Panneerselvam, Rajkumar Krishnan","doi":"10.1007/s00784-025-06501-3","DOIUrl":"10.1007/s00784-025-06501-3","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the awareness and practices of oral and maxillofacial surgeons (OMFS) regarding the management of facial trauma in patients with Alcohol Use Disorder (AUD), focusing on alcohol withdrawal syndrome (AWS), perioperative abstinence and its psychological impact.</p><p><strong>Materials and methods: </strong>A cross-sectional, questionnaire-based study was conducted among 499 OMFS practitioners across India. An investigator-designed, validated, 17-item questionnaire covered six domains: alcohol history, abstinence, AWS management protocols, stress/quality of life and therapeutic alcohol use. Participants were stratified by clinical experience and leadership status. Data were analysed using descriptive statistics and Chi-square tests via Jamovi. Statistical significance was set at 0.05.</p><p><strong>Results: </strong>Most surgeons (95%) recorded alcohol-related history; 92% advised pre/post-operative abstinence, primarily for anaesthetic safety. Despite 97% awareness of AWS, 76% lacked familiarity with its prophylaxis. Only 28% reported existing institutional guidelines, of which two-thirds were unaware of specifics. Stress due to sudden abstinence was acknowledged by 95%, yet only 47.7% implemented mitigation strategies. Notably, 56% supported therapeutic alcohol use for AWS management. Surgeons with greater experience or leadership roles showed reduced abstinence durations, increased stress management, and greater awareness of AWS prophylaxis (statistically significant).</p><p><strong>Conclusions: </strong>Substantial gaps exist in standardized protocols and interdisciplinary approaches to managing trauma in AUD patients. These disparities are more pronounced among less experienced and non-leader surgeons.</p><p><strong>Clinical relevance: </strong>The findings underscore the need for targeted training, standardized clinical guidelines, and integration of psychiatric care in maxillofacial trauma management for patients with AUD, to improve outcomes and reduce complications related to AWS.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"409"},"PeriodicalIF":3.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820753","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micro-CT analysis of cement adaptation and porosity in 3D-Printed permanent resin crowns before and after chewing simulation.","authors":"Emel Arslan, Ali Keles","doi":"10.1007/s00784-025-06497-w","DOIUrl":"10.1007/s00784-025-06497-w","url":null,"abstract":"<p><strong>Objective: </strong>This study evaluates cementation gap, cement volume, and porosity levels in three-dimensional crown restorations using four permanent resin materials and printers, and examines changes after thermomechanical ageing.</p><p><strong>Materials and methods: </strong>In the study, phantom models prepared on the maxillary first premolar were used, and the digital scanning, CAD design, 3D printing, cementation, and ageing processes were carried out according to standard protocols. The samples were divided into four groups based on the permanent resin material used: Group C (Methacrylate-based resin), Group S (UDMA-based composite), Group P (Bis-GMA/TEGDMA-based), and Group V (Bis-EMA/UDMA-based). All samples were designed with a 50 μm virtual cementation gap and evaluated by micro-CT before and after ageing.</p><p><strong>Results: </strong>The findings showed statistically significant differences between the groups in terms of cementation gap and porosity volume (p < 0.001). The lowest void volume and porosity were measured in the group C, while the highest values were observed in the group S. No significant difference was observed between the groups in terms of total cement volume. Additionally, a strong positive correlation was found between cement volume and porosity.</p><p><strong>Conclusions: </strong>The obtained data reveal that the resin material used and the production process play a decisive role in the internal compatibility of restorations. Thermomechanical ageing, on the other hand, caused significant changes, particularly in structural properties. These results indicate that permanent resin restorations produced by 3D printing should be evaluated for their clinical viability considering cement gap and porosity behavior.</p><p><strong>Clinical relevance: </strong>This study has revealed that the cementation gap and porosity levels of permanent resin crowns produced with a 3D printer vary significantly depending on the type of material used and the production process. Therefore, in clinical applications, not only aesthetic and mechanical properties but also cementation compatibility and microstructural properties should be taken into consideration.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"408"},"PeriodicalIF":3.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Annexin A1 levels in polycystic ovary syndrome: impact of professional mechanical plaque removal.","authors":"Cansu Can Yasar, Seda Ates, Turgut Aksoy, Aysegul Yabaci Tak, Esra Demir, Sadiye Gunpinar","doi":"10.1007/s00784-025-06489-w","DOIUrl":"10.1007/s00784-025-06489-w","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the local inflammatory profile in women with polycystic ovary syndrome (PCOS) by assessing interleukin (IL)-6, IL-10, and annexin A1 (ANXA1) levels in saliva and gingival crevicular fluid (GCF), and to compare the clinical and biochemical responses to proffessional mechanical plaque removal (PMPR) between women with PCOS and systemically healthy individuals.</p><p><strong>Methods: </strong>Eighty women were allocated into four groups: (1) PCOS-healthy periodontium (PCOSH), (2) PCOS-gingivitis (PCOSG), (3) systemically healthy-gingivitis (SG), (4) systemically and periodontally healthy (SH). Clinical periodontal parameters and saliva/GCF samples were collected at baseline and 6 weeks after PMPR. IL-6, IL-10, and ANXA1 levels were measured by ELISA. Data were analyzed using one-way ANOVA, Kruskal-Wallis tests, and multiple linear regression.</p><p><strong>Results: </strong>Both gingivitis groups showed comparable clinical improvements and significant reductions in salivary IL-6 levels and the IL-6/IL-10 ratio following PMPR, independent of PCOS status. Notably, GCF ANXA1 levels increased in PCOSG but decreased in SG. In the PCOSG group, baseline levels of estradiol and follicle-stimulating hormone were significant predictors of changes in GCF ANXA1, as indicated by multiple regression analysis.</p><p><strong>Conclusion: </strong>PMPR may lead to similar clinical and local biochemical outcomes in patients with gingivitis, regardless of PCOS status. ANXA1 may have a specific role in modulating gingival inflammation in women with PCOS.</p><p><strong>Clinical relevance: </strong>This study highlights the importance of managing gingivitis in women with PCOS, suggesting that periodontal treatment may result in comparable improvements. Additionally, the findings suggest a potential modulatory role for ANXA1 in the periodontal inflammatory response associated with PCOS.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"406"},"PeriodicalIF":3.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The low invasiveness design (LID) flap in immediate implant placement: a 20-patient case series on a novel flap design based on new insights into papilla vascularization.","authors":"D De Santis, S Wang, P Montagna, P Faccioni, A Zangani, F Balliu, F Melloni, F Gelpi","doi":"10.1007/s00784-025-06496-x","DOIUrl":"10.1007/s00784-025-06496-x","url":null,"abstract":"<p><strong>Objectives: </strong>This study presents a novel Low Invasiveness Design (LID) flap for Immediate Implant Placement (IIP) and evaluates its clinical and esthetic outcomes in a 20-patient retrospective case series. The LID flap is based on recent insights into papilla vascularization and aims to balance the benefits of flapless and conventional flap techniques.</p><p><strong>Materials and methods: </strong>Twenty patients requiring IIP in the anterior maxilla were treated with the LID flap. The study included non-smoking, systemically healthy individuals. Esthetic outcomes and patient satisfaction were assessed one year after final prosthetic rehabilitation respectively using the Pink Esthetic Score (PES) and the Visual Analogue Scale (VAS).</p><p><strong>Results: </strong>No implant failures or major complications were reported. A minor case of flap distress (5%) was observed and healed spontaneously without intervention. The mean PES was 12.35 ± 0.99, indicating satisfactory esthetic outcomes, while the mean VAS score was 9.15 ± 0.75. The flap design successfully preserved papilla height and granted soft tissue stability.</p><p><strong>Conclusions: </strong>The LID flap presents a promising approach for IIP, preserving soft tissue esthetics while ensuring surgical precision. The preliminary results suggest that this technique may provide an alternative to traditional flap designs.</p><p><strong>Clinical relevance: </strong>The LID flap may serve as an alternative to traditional incision designs in IIP procedures.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"410"},"PeriodicalIF":3.1,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12343692/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144820755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"- Comments on 'mapping the evolving trend of research on class III malocclusion: a bibliometric analysis' by Hu et al.","authors":"Yuh-Shan Ho, Nikolaos Christidis","doi":"10.1007/s00784-025-06495-y","DOIUrl":"10.1007/s00784-025-06495-y","url":null,"abstract":"","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"403"},"PeriodicalIF":3.1,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12336080/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144815932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of bleaching on white spot lesions: hydrogen peroxide permeability and color alteration.","authors":"Laryssa Mylenna Madruga Barbosa, Bruno Baracco, Taynara S Carneiro, Michael Willian Favoreto, Michel Wendlinger, Daniel Jiménez-Díez, Laura Ceballos, Alessandro D Loguercio","doi":"10.1007/s00784-025-06490-3","DOIUrl":"10.1007/s00784-025-06490-3","url":null,"abstract":"<p><strong>Objectives: </strong>To assess the penetration of hydrogen peroxide (HP) into the pulp chamber and the bleaching efficacy on teeth with white spot lesions (WSLs) compared to sound teeth, when subjected to both in-office and at-home bleaching treatments.</p><p><strong>Materials and methods: </strong>Forty premolars were allocated into four groups (n = 10 each): sound teeth and teeth with artificially induced WSLs, both subjected to at-home bleaching (16% carbamide peroxide) and in-office bleaching (35% hydrogen peroxide). WSLs were induced in half of the specimens using a 14-day pH-cycling protocol alternating between demineralizing and remineralizing solutions. HP permeability (µg/mL) and color parameters (L*, a*, b*, and WI_D) were quantitatively assessed using a Cary UV-Vis 100 spectrophotometer and a VITA Easyshade Advance 4.0 digital spectrophotometer, respectively. Statistical analyses were performed using two-way and three-way ANOVA, with post hoc comparisons by Tukey's, at a significance level of α = 0.05.</p><p><strong>Results: </strong>WSLs subjected to in-office bleaching exhibited higher HP penetration compared to the other groups (p < 0.05). After bleaching, WSLs showed significantly lower L* and WI_D values than sound teeth, regardless of the bleaching protocol or time point (p < 0.05). For a*, higher values were observed in WSLs after at-home bleaching, while for b* values no significant differences were found (p > 0.05). No significant difference in WI_D was observed between bleaching methods for WSLs teeth (p > 0.05).</p><p><strong>Conclusions: </strong>White spot lesions exhibited greater HP permeability and less favorable optical outcomes compared to sound teeth, particularly after in-office bleaching.</p><p><strong>Clinical relevance: </strong>Teeth with white spot lesions are more susceptible to HP diffusion and present less favorable whitening results. At-home bleaching may be a safer and more esthetically favorable conservative treatment option for managing white spot lesions.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"401"},"PeriodicalIF":3.1,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predicting anterior repositioning splint efficacy in disc displacement with reduction using MRI-based texture and quantitative analysis: a retrospective study.","authors":"Bo Gao, Yan Dong, Yidan Shan, Xin Xu, Chao Wang, Jie Min, Xiuxiu Lai, Baiping Fu","doi":"10.1007/s00784-025-06481-4","DOIUrl":"10.1007/s00784-025-06481-4","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objectives: &lt;/strong&gt;To quantitatively analyze potential factors influencing the efficacy of anterior repositioning splint (ARS) therapy in patients with disc displacement with reduction (DDWR), and to explore the prognostic value of MRI-based texture analysis.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Materials and methods: &lt;/strong&gt;82 patients with 140 joints of DDWR were conducted in the retrospective study from 2020 to 2022. The custom maxillary ARS was fabricated based on incisal edge-to-edge occlusal record. Patients were instructed to wear the ARS full-time and adjusted monthly for at least 6 months. MRI evaluation of 140 joints was conducted at four check-up time: pre-treatment (T0), the initiation of ARS insertion (T1), treatment completion (T2), and follow-up (T3). TMJ disc morphology and position were quantified based on MRI images, and post-ARS therapy outcomes were stratified into three categories: excellent, improved, or poor. In sequence, texture analysis (TA) of the retrodiscal tissue (RDT) was conducted based on MRI images. Five texture parameters were extracted and calculated using a gray-level co-occurrence matrix (GLCM). Statistical analysis including chi-square test, independent samples T test or Kruskal-Wallis test was conducted.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Among 82 DDWR patients (140 joints), 84 joints (60%) achieved excellent outcomes, characterized by high initial disc recapture (98.8%) and new bone formation (15.5%), after ARS treatment, while 47 joints (34%) showed improvement and 9 joints (6%) had poor results. Quantitative analysis revealed that mandibular protrusive distance was significantly greater in the excellent group (3.50 ± 1.70 mm) than in the improved group (2.80 ± 1.20 mm; P = 0.032). Longitudinal MRI images revealed significant reductions in disc displacement distance (mean Δ = 3.11 mm, P &lt; 0.01) and disc-condyle angle (mean Δ = 45.96°, P &lt; 0.01) after ARS treatment, although minor recurrence occurred during follow-up. Multivariable logistic regression analysis revealed that the TA parameter of Angular Second Moment(ASM) exhibited a strong positive association with clinical outcomes in both the excellent (adjusted OR = 9.545, 95% CI: 1.785-51.056, P &lt; 0.05) and improved (adjusted OR = 8.272, 95% CI: 1.568-43.636, P &lt; 0.05) groups compared to the poor group. Each unit increase in ASM was associated with approximately 9.5-fold and 8.3-fold higher odds of achieving excellent or improved outcomes, respectively.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;ARS treatment could be used to correct disc-condyle relationship and reduce disc displacement distance in patients with DDWR. Multiple factors influence ARS outcomes. The high disc recapture rate following ARS insertion was correlated with excellent therapeutic outcomes, and mandibular protrusive distance may influence the successful disc recapture. Texture analysis might be identified ASM as a potential predictive imaging biomarker.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical relevance: &lt;/strong&gt;ARS i","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 9","pages":"402"},"PeriodicalIF":3.1,"publicationDate":"2025-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144803767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}