Clinical Oral Investigations最新文献

{"title":"Prevalence of molar incisor hypomineralization and characteristics of affected first permanent and second primary molars among children in Jeddah.","authors":"Heba Jafar Sabbagh, Abdulaziz Abdullah Alharthi, Abdullah Muslih Almushali, Sultan Osama Jiffri, Meshari Hussain Alkalbi, Ghazal Abdulhadi Bokhari, Fatmah Yousef Aljehani, Nada Othman Bamashmous, Khlood Baghlaf","doi":"10.1007/s00784-025-06390-6","DOIUrl":"10.1007/s00784-025-06390-6","url":null,"abstract":"<p><strong>Background: </strong>Molar-incisor hypomineralization (MIH) results in teeth that are highly prone to dental caries, sensitive to temperature changes and challenging to restore due to the atypical cavities or coronal deformation.</p><p><strong>Objectives: </strong>This study aimed to assess the prevalence of MIH, the characteristics of affected first permanent molars (FPMs), and the relationship between MIH and hypomineralized second primary molars (HSPM) among primary school children in Jeddah, Saudi Arabia.</p><p><strong>Methods: </strong>Jeddah City was divided into three regions, and 12-schools were randomly selected through stratified sampling. The inclusion criteria involved 7 to 9 years old children who had at least one erupted FPM. The caries status was assessed using the World Health Organization (WHO) indices dmft/DMFT. The assessment of MIH was conducted based on the criteria established by the European Academy of Pediatric Dentistry at their meeting in Athens in 2003.</p><p><strong>Results: </strong>A total of 2,019 children participated with an MIH prevalence of MIH 18.3% (369 patients), and an HSPM prevalence of 1.8% (36 patients). The mean DMFT/dmft index was 5.99 ± 4.08. White creamy opacities were the most common presentation of FPMs and HSPM (about 80% of MIH-affected FPMs). A statistically significant association was found between MIH and HSPM and increased odds ratio of MIH with HSPM (P < 0.001, OR = 5.96, and 95% CI: 5.3-6.57).</p><p><strong>Conclusion: </strong>The prevalence of MIH was higher than compared to the reported Middle East studies. The white creamy opacities were the most common presentations of MIH. A strong association existed between MIH and HSPM and an increased risk of having MIH when the child was found to have HSPM.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"315"},"PeriodicalIF":3.1,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144149443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Predictive modelling of mandibular osteoradionecrosis in head and neck cancer patients: clinical and dosimetric insights.","authors":"Julian Leeder, Ali Modabber, Frank Hölzle, Michael J Eble, Ahmed Allam Mohamed","doi":"10.1007/s00784-025-06385-3","DOIUrl":"10.1007/s00784-025-06385-3","url":null,"abstract":"<p><strong>Introduction: </strong>Mandibular osteoradionecrosis (ORN) is a serious complication of radiotherapy (RT) for head and neck cancer (HNC), with an incidence of 3-15%. ORN results from radiation-induced bone necrosis and may require surgical intervention. This study investigates clinical and dosimetric predictors of ORN risk and develops a predictive model for individualized risk assessment.</p><p><strong>Materials and methods: </strong>This retrospective case-control study included 298 HNC patients treated with RT or chemoradiotherapy between January 2012 and May 2020. Dosimetric parameters, including mandibular V10-V60, mean dose (Dmean), and maximum dose (Dmax), were analyzed alongside clinical data such as age, tumor site, smoking history, and dental extractions.</p><p><strong>Results: </strong>Over a median follow-up of 32.4 months, 20 patients (6.7%) developed ORN, with a 5-year cumulative incidence of 7.4%. Multivariate analysis identified mandibular V50 (HR = 1.05, p = 0.0015) and post-RT dental extractions (HR = 2.51, p < 0.0001) as significant ORN risk factors, while age was protective (HR = 0.96, p = 0.047). A V50 cutoff of 25.4 cm³ was most predictive (p = 0.0016). The multivariate model incorporating V50, age, and dental extractions demonstrated strong accuracy (C-index: 0.815, AUC: 0.8).</p><p><strong>Conclusion: </strong>V50 and post-RT dental extractions are key predictors of ORN. The developed nomogram enables personalized risk assessment, supporting treatment optimization. These findings emphasize the need for tailored RT planning and dental care to mitigate ORN risk, warranting validation in multi-institutional cohorts.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"313"},"PeriodicalIF":3.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12106553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141522","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated landmark-based mid-sagittal plane: reliability for 3-dimensional mandibular asymmetry assessment on head CT scans.","authors":"Sophie Alt, Laurent Gajny, Françoise Tilotta, Thomas Schouman, Gauthier Dot","doi":"10.1007/s00784-025-06397-z","DOIUrl":"10.1007/s00784-025-06397-z","url":null,"abstract":"<p><strong>Objective: </strong>The determination of the mid-sagittal plane (MSP) on three-dimensional (3D) head imaging is key to the assessment of facial asymmetry. The aim of this study was to evaluate the reliability of an automated landmark-based MSP to quantify mandibular asymmetry on head computed tomography (CT) scans.</p><p><strong>Materials and methods: </strong>A dataset of 368 CT scans, including orthognathic surgery patients, was automatically annotated with 3D cephalometric landmarks via a previously published deep learning-based method. Five of these landmarks were used to automatically construct an MSP orthogonal to the Frankfurt horizontal plane. The reliability of automatic MSP construction was compared with the reliability of manual MSP construction based on 6 manual localizations by 3 experienced operators on 19 randomly selected CT scans. The mandibular asymmetry of the 368 CT scans with respect to the MSP was calculated and compared with clinical expert judgment.</p><p><strong>Results: </strong>The construction of the MSP was found to be highly reliable, both manually and automatically. The manual reproducibility 95% limit of agreement was less than 1 mm for -y translation and less than 1.1° for -x and -z rotation, and the automatic measurement lied within the confidence interval of the manual method. The automatic MSP construction was shown to be clinically relevant, with the mandibular asymmetry measures being consistent with the expertly assessed levels of asymmetry.</p><p><strong>Conclusion: </strong>The proposed automatic landmark-based MSP construction was found to be as reliable as manual construction and clinically relevant in assessing the mandibular asymmetry of 368 head CT scans.</p><p><strong>Clinical relevance: </strong>Once implemented in a clinical software, fully automated landmark-based MSP construction could be clinically used to assess mandibular asymmetry on head CT scans.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"311"},"PeriodicalIF":3.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Growth pattern prediction of maxillary segments in infants with unilateral cleft lip and palate: a prospective in vivo study.","authors":"Sarah Bühling, Cedric Thedens, Sara Eslami, Iulia Dahmer, Babak Sayahpour, Nicolas Plein, Lukas Benedikt Seifert, Robert Sader, Stefan Kopp","doi":"10.1007/s00784-025-06378-2","DOIUrl":"10.1007/s00784-025-06378-2","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of the study was to identify the best prediction model for the growth pattern of the maxillary segments of infants with unilateral cleft lip and palate post birth and prior to the primary surgical cleft closure.</p><p><strong>Materials and methods: </strong>195 digital maxillary models of 50 infants with unilateral cleft lip and palate were collected during their preoperative alveolar molding therapy period. Intraoral scans were taken shortly after birth, at the monthly checkups and just before the surgical cleft closure at approximately 6 months of age. Surface measurements of maxillary segments were conducted using the diagnostic program OnyxCeph³™. For identifying the best fit for the growth pattern, mixed-effects regression models (fractional polynomials and B-splines) with the surface measurement as dependent variable, patient age (days) as predictor and the patient as random effect were fitted to the data. The best fit was selected according to the Akaike Information Criterium. A likelihood ratio test was performed for comparing the selected model with the intercept-only model.</p><p><strong>Results: </strong>The linear regression with mixed effects model showed the best fit for the total area, the area of the large segment and the area of the small segment. A highly significant association between the surface area and patient age was observed (p < 0.001). An increase of the area with time was estimated at 2.88 mm² per day for the total area, 1.62 mm² per day for the area of the large segment and 1.25 mm² per day for the area of the small segment. The likelihood ratio tests indicated that the linear regression models were significantly better than the intercept-only models for all the measured areas (p < 0.01).</p><p><strong>Conclusion: </strong>The growth pattern for the maxillary segments of patients with unilateral cleft lip and palate in the preoperative period can be best predicted by using a linear regression model. The growth curve model developed by the present study can be used in future treatment planning of patients with unilateral cleft lip and palate.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"312"},"PeriodicalIF":3.1,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12104111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144141077","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endoscopic surveillance of poor oral hygiene in vulnerable patients at pneumonia risk.","authors":"Wei-Kuo Chang, Yu-Ling Pan, Chung-Hsing Li","doi":"10.1007/s00784-025-06392-4","DOIUrl":"10.1007/s00784-025-06392-4","url":null,"abstract":"<p><strong>Objectives: </strong>This study evaluated the routine use of upper gastrointestinal (UGI) endoscopy combined with oral-pharynx-larynx surveillance to assess oral hygiene and its impact on pneumonia development in vulnerable patients.</p><p><strong>Materials and methods: </strong>This retrospective observational study included 411 hospitalized participants who underwent UGI endoscopy with concurrent oral-pharynx-larynx examination. Poor oral hygiene was identified based on endoscopic findings, including nasopharyngeal pooling secretions, diffuse inspissated oral secretions, and food particles, tartar, or plaque. Among these, 68 participants were identified with poor oral hygiene, while the remaining 343 participants comprised the control group. Records of basic and clinical characteristics were analyzed.</p><p><strong>Results: </strong>Gastroenterologists identified 2.6% (68/2,567) of participants with poor oral hygiene during endoscopy. The frequency of pneumonia was notably higher in the poor oral hygiene group (3.0 ± 1.5 episodes/person-year) compared to the control group (0.6 ± 2.0 episodes/person-year, p < 0.001). Multivariable analysis showed that poor oral hygiene significantly increased the risk of pneumonia requiring hospitalization (p < 0.001). Enteral tube feeding was also independently associated with increased pneumonia risk (p = 0.003). Kaplan-Meier analysis indicated a significantly higher cumulative incidence of pneumonia in the poor oral hygiene group.</p><p><strong>Conclusions: </strong>Poor oral hygiene identified during the endoscopic examination was significantly associated with an increased risk of pneumonia requiring hospitalization.</p><p><strong>Clinical relevance: </strong>Gastroenterologists can identify vulnerable patients with poor oral hygiene during endoscopy, providing an opportunity for referral to dentists or primary caregivers for timely intervention and management.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"310"},"PeriodicalIF":3.1,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103358/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recent innovations in endodontic irrigation and effects on smear layer removal: an ex-vivo study.","authors":"Ayfer Atav, Alessio Zanza, Aysenaz Gunes, Luca Testarelli, Massimo Galli, Qorri Erda, Michela Relucenti, Orlando Donfrancesco, Gianluca Gambarini","doi":"10.1007/s00784-025-06387-1","DOIUrl":"10.1007/s00784-025-06387-1","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the cleaning efficacy of different irrigation activation techniques in removing smear layers from root canals.</p><p><strong>Materials and methods: </strong>Ninety lower premolars with straight root canals were assigned to six experimental groups (n = 15 each): control group, conventional irrigation, passive ultrasonic activation (PUI), distilled water laser-activated irrigation (LAI), PulpSucker irrigation, and iVac irrigation. Each canal was shaped to size 30/04 and irrigated with 5% NaOCl. The final rinse was performed according to the experimental group. After chemo-mechanical procedures, the teeth were split longitudinally and subjected to scanning electron microscopic (SEM) analysis for each root canal third (coronal, middle, and apical). The presence of smear layer was evaluated using a 5-grade scoring system at 500× and 1000× magnification. Following the Shapiro-Wilk test, data were statistically analyzed using the nonparametric Kruskal-Wallis test, followed by the post-hoc Dunn test with Bonferroni correction (α = 5%), to compare the effectiveness of smear layer removal. The Friedman test and post-hoc Wilcoxon signed-rank test with Bonferroni correction (α = 5%) were performed to assess significant differences in smear layer removal among the different tooth thirds.</p><p><strong>Results: </strong>Activated irrigation techniques significantly outperformed conventional irrigation (p <.05), with the iVac technique demonstrating the best results in smear layer removal in the apical third. LAI and PUI showed comparable results across all tooth thirds. Significant differences in cleaning efficacy were observed among the different tooth thirds within each experimental group, with the apical third exhibiting the highest presence of smear layer.</p><p><strong>Conclusion: </strong>Within the limitations of the study, irrigant activation demonstrated higher efficiency in smear layer removal from root canal systems compared to conventional irrigation techniques. iVac showed the best cleaning performance in each third, particularly in the apical third.</p><p><strong>Clinical relevance: </strong>iVac technology offers significant potential for improving clinical outcomes.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"309"},"PeriodicalIF":3.1,"publicationDate":"2025-05-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12103479/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144135946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of a 1% ibuprofen nanostructured topical gel in reducing in-office bleaching sensitivity following 35% hydrogen peroxide application: a randomized, controlled, triple-blind, split-mouth clinical trial.","authors":"Francisca Jennifer Duarte de Oliveira, Bárbara Faria de Sá Barbosa, Mariana Silva de Bessa, Patrick Wesley Marques de Boa, Kaiza de Sousa Santos, Arnóbio Antônio da Silva Júnior, Boniek Castillo Dutra Borges","doi":"10.1007/s00784-025-06386-2","DOIUrl":"10.1007/s00784-025-06386-2","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the efficacy of a 1% ibuprofen nanostructured topical gel in controlling in-office bleaching sensitivity (BS) and its impact on tooth color change.</p><p><strong>Methods: </strong>A randomized, controlled, triple-blind, split-mouth clinical trial was conducted with 40 participants. The nanostructured ibuprofen gel (I) and placebo (P) were applied for 10 min before and after bleaching (35% hydrogen peroxide; 1 × 50 min; two sessions, one week apart) on each hemi-arch, randomly assigned. Bleaching sensitivity (BS) was assessed using the Visual Analog Scale (VAS), calculating absolute risk, relative risk, and BS intensity. The color change was measured subjectively with the Vitapan Classical^® shade guide (ΔSGU) and objectively with the EasyShade^® spectrophotometer (ΔE, ΔE00, ΔWID). Statistical analyses were performed using the paired t-test, Wilcoxon, and McNemar tests (p < 0.05).</p><p><strong>Results: </strong>No statistically significant differences were found between I and P for absolute risk of BS (80% vs. 77%) or BS intensity at 1 h (0.6 vs. 0.8), 24 h (0.2 vs. 0.1), or 48 h (0.0 vs. 0.0). BS intensity was low to moderate. The color change was also statistically similar between groups: ΔE (12.81 ± 4.68 vs. 12.65 ± 5.32), ΔE00 (8.50 ± 3.71 vs. 8.52 ± 4.03), ΔWID (8.06 ± 7.55 vs. 8.34 ± 6.90), and ΔSGU (7.42 ± 2.94 for both).</p><p><strong>Conclusion: </strong>The novel 1% ibuprofen nanostructured topical gel was ineffective in reducing BS and did not affect tooth color change.</p><p><strong>Clinical relevance: </strong>The 1% ibuprofen nanostructured topical gel did not interfere with tooth color change but was ineffective in reducing the risk or intensity of in-office bleaching sensitivity. Although the formulation yielded positive results in a previous animal study, these outcomes were not replicated in humans, underscoring the need for clinical trials to confirm the efficacy of any approach for managing bleaching sensitivity, even if successful in animal models.</p><p><strong>Clinical trial registration number: </strong>RBR-4ng46xj.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"308"},"PeriodicalIF":3.1,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144126709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and accuracy of clear aligners in treatment of deep bite: a systematic review.","authors":"Fatemah Husain, Joseph Riccardi, Lia Alletto, Elizabeth Stellrecht, Arash Poursattar Bejehmir, Thikriat Al-Jewair","doi":"10.1007/s00784-025-06381-7","DOIUrl":"10.1007/s00784-025-06381-7","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic review evaluated the effectiveness and accuracy of clear aligners (CA) for dental and skeletal deep bite correction.</p><p><strong>Methods: </strong>Searches in PubMed, Embase, Cochrane, and grey literature were conducted from inception to May 2024. Studies included all age groups with dental and/or skeletal deep bite treated with CA, with or without control groups, using prospective or retrospective designs. Risk of bias was assessed through Risk Of Bias In Non-randomised Studies-of Interventions (\"ROBIN-I\").</p><p><strong>Results: </strong>Out of 829 studies screened, 18 were included. Eight studies assessed CA's effectiveness, eight evaluated CA accuracy, and two examined both. The effectiveness in bite opening ranged from 0.4 mm to 3.8 mm, while the accuracy in deep bite correction varied between 33% and 48.88% across all studies. According to GRADE, the evidence for both CA accuracy and effectiveness in deep bite treatment was rated as low quality due to high risk of bias, indirectness, and imprecision, despite consistent findings across studies.</p><p><strong>Conclusion: </strong>CA can effectively correct mild to moderate dentoalveolar deep bites; however, its efficacy in skeletal cases compared to full-fixed appliance (FFA) remains uncertain. Planned correction of deep bites with CA often falls short of the actual achieved correction, making overcorrection or refinements necessary for achieving the desired treatment outcomes. Due to the limited quality and methodological variability among the studies, recommending CA as a superior modality for deep bite correction remains premature.</p><p><strong>Clinical relevance: </strong>CA may be effective for dentoalveolar deep bites but often needs adjustments for accuracy and is less effective than FFA for skeletal cases.</p><p><strong>Registration: </strong>The review protocol was registered in PROSPERO (#CRD42022334078).</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"306"},"PeriodicalIF":3.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis of removable complete dentures considering the level of mandibular residual ridge resorption: a systematic review and meta-analysis.","authors":"Guilherme Almeida Borges, Maria Helena Rossy Borges, Caroline Dini, Raissa Micaella Marcello-Machado, Valentim A R Barão, Marcelo Ferraz Mesquita","doi":"10.1007/s00784-025-06379-1","DOIUrl":"10.1007/s00784-025-06379-1","url":null,"abstract":"<p><strong>Objective: </strong>To compare clinical outcomes in atrophic (AM) and non-atrophic (NAM) mandibles of edentulous patients rehabilitated with mandibular removable complete dentures (CD) or implant mandibular overdentures (IMO).</p><p><strong>Materials and methods: </strong>Non-randomized clinical studies were searched in 8 databases. Articles were assessed by the risk of bias in non-randomized studies of interventions. Datasets for CDs comparing AM and NAM were plotted [masticatory function, maximum occlusal biting force (MOBF), oral health-related quality of life (OHRQoL)]. Residual ridge (AM and NAM) data (masticatory function, OHRQoL, implant survival, marginal bone loss, and maintenance events) in IMO were also combined.</p><p><strong>Results: </strong>23 studies were included. Only 1 was classified as low risk of bias. Superior masticatory performance was observed in the NAM group rehabilitated with CD (P <.001). NAM group rehabilitated with CD exhibited increased MOBF (P <.05). Once patients were treated with IMO, improvements were observed in swallowing threshold (number of cycles and time) in the NAM group (P <.05). Comparable results of OHRQoL were noted for both groups (AM and NAM) and rehabilitations (CD and IMO). Similar peri-implant outcomes were displayed for IMO rehabilitation in AM and NAM patients. Most common event for IMO wearers (AM and NAM) was replacement of retention insert.</p><p><strong>Conclusion: </strong>AM patients presented suboptimum masticatory function whether using CD or IMO. CD wearers with AM also had a reduced MOBF compared with NAM patients.</p><p><strong>Clinical relevance: </strong>Clinicians should carefully monitor residual ridge resorption to guide treatment planning and prognosis, particularly in cases of AMs. Our findings indicate that AMs may negatively impact the clinical performance of both CD and IMO rehabilitations.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"307"},"PeriodicalIF":3.1,"publicationDate":"2025-05-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of enamel remineralization potential and anticariogenic efficacy of polydopamine coated biogenic amorphous calcium phosphate.","authors":"M Madhana Madhubala, R Jayasree, T S Sampath Kumar, Janis Locs, Sekar Mahalaxmi","doi":"10.1007/s00784-025-06384-4","DOIUrl":"10.1007/s00784-025-06384-4","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to comparatively evaluate the enamel remineralization potential and antibacterial efficacy of polydopamine coated chicken eggshell derived amorphous calcium phosphate (PDA -EACP) and casein phosphopeptide-amorphous calcium phosphate (CPP-ACP).</p><p><strong>Materials and methods: </strong>EACP was synthesized from chicken eggshells, functionalized with PDA, and then characterized using high-resolution scanning electron microscopy with energy-dispersive X-ray spectroscopy (HRSEM-EDX), Fourier transform infrared spectroscopy (FTIR), and X-ray diffraction (XRD). 120 enamel slabs were demineralized and randomly divided into 5 groups for the following therapeutic treatments: Group I- Control (no treatment); Group II - CPP-ACP; Group III- EACP; Group IV- PDA; Group V- PDA-EACP and subjected to a 28-day pH cycling regimen. The remineralization effects were assessed by measuring changes in Vickers Microhardness (VMH), analyzing surface morphology using SEM and performing elemental and chemical analysis through EDX and XRD. Antibacterial efficacy was evaluated using agar diffusion, direct contact, and biofilm inhibition assays using fluorescent staining method against Streptococcus mutans.</p><p><strong>Results: </strong>Post-demineralization, VMH values dropped from 340 to 350 VHN to ~ 200-214 VHN. PDA-EACP showed the highest remineralization (330.4 ± 12.2 VHN), significantly greater than EACP (295.6 ± 10.4 VHN) and CPP-ACP (265.3 ± 9.8 VHN) (p < 0.001). EDX analysis showed Ca/P ratio increased to 2.31 ± 0.34 (EACP) and 1.69 ± 0.06 (PDA-EACP). XRD confirmed superior hydroxyapatite crystallization in PDA-EACP. PDA-EACP exhibited the largest inhibition zone (15.6 ± 1.3 mm) and highest biofilm reduction (72.6% bacterial death at 1:1 dilution).</p><p><strong>Conclusion: </strong>PDA-EACP enhances enamel remineralization and antibacterial activity more than CPP-ACP.</p><p><strong>Clinical relevance: </strong>PDA-EACP provides a biomimetic, cost-effective, and biocompatible alternative to synthetic remineralizing agents to treat early enamel lesions. Its strong adhesion potential, mineralization and antimicrobial properties could improve clinical outcomes in managing and preventing incipient carious lesions.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 6","pages":"302"},"PeriodicalIF":3.1,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}