Effect of 0.8% Hyaluronic Acid-Based Gel on Clinical and Biomolecular parameters in the surgical periodontal treatment of Stage III periodontitis patients: a randomized, split-mouth clinical trial.
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引用次数: 0
Abstract
Objectives: This study aimed to assess the effect of the application of 0.8% hyaluronic acid (HA) gel together with open flap debridement (OFD) on clinical parameters and inflammatory and oxidative biomarkers in gingival crevicular fluid (GCF) of the patients with stage III periodontitis.
Materials and methods: This split-mouth study included 18 patients diagnosed with Stage III Grade B or C periodontitis. Quadrants were randomly assigned to test (OFD + 0.8% HA gel) and control groups (OFD alone). Clinical parameters and GCF samples were obtained at the treated sites at baseline (T0), at pre-surgery (T1), 1 month (T2) and 6 months (T3) post-surgery. Interleukin (IL)-6, IL-8, IL-10, IL-17 A, total antioxidant status (TAS), and total oxidant status (TOS) levels in GCF were analyzed using enzyme-linked immunosorbent assay.
Results: The lower GCF IL-6, IL-8, IL-17 A and TOS levels and higher GCF IL-10 and TAS levels were found after treatment (T1,T2,T3) compared to the T0 period in intragroup comparisons (P < 0.05). There were statistically significantly higher GCF IL-10 levels in the T2 and T3 periods and significantly lower GCF IL-17 A levels in the T3 period in the test group compared to the control group (P < 0.05), no significant difference was determined between the groups in GCF IL-6, IL-8, TAS and TOS levels during the time periods.
Conclusion: The local application of 0.8% HA gel with OFD provides to beneficial effect GCF IL-10 and IL-17 A levels in severe periodontitis patients.
Clinical relevance: The application of 0.8% HA gel addictive with OFD provides positive results in GCF IL-10 and IL-17 A levels in patients with Stage III periodontitis compared to OFD alone.
期刊介绍：
The journal Clinical Oral Investigations is a multidisciplinary, international forum for publication of research from all fields of oral medicine. The journal publishes original scientific articles and invited reviews which provide up-to-date results of basic and clinical studies in oral and maxillofacial science and medicine. The aim is to clarify the relevance of new results to modern practice, for an international readership. Coverage includes maxillofacial and oral surgery, prosthetics and restorative dentistry, operative dentistry, endodontics, periodontology, orthodontics, dental materials science, clinical trials, epidemiology, pedodontics, oral implant, preventive dentistiry, oral pathology, oral basic sciences and more.
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