Clinical Oral Investigations最新文献

{"title":"Microbial spectrum and resistance of odontogenic abscesses - microbiological analysis using next generation sequencing.","authors":"Felix Thol, Felix Benjamin Warwas, Nikolai Spuck, Franz-Josef Kramer, Nils Heim","doi":"10.1007/s00784-024-06097-0","DOIUrl":"10.1007/s00784-024-06097-0","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to map the microbiome of odontogenic abscesses using next-generation sequencing (NGS) to identify bacterial and fungal species, as well as antibiotic resistances.</p><p><strong>Materials and methods: </strong>Wound swabs were taken from patients treated for odontogenic abscesses at the Department of Oral and Maxillofacial Plastic Surgery, University Hospital Bonn. NGS was used to analyze the swabs, and bioinformatic analysis assigned the genetic material to microorganism profiles and identified antibiotic resistances.</p><p><strong>Results: </strong>Bacteria were detected in all samples from 51 patients. Anaerobes were found in 50 swabs, while aerobic bacteria were detected in 30. Four of the five most common bacterial genera were anaerobes (Fusobacterium, Prevotella, Parvimonas, Porphyromonas). A median of eight genera were identified per swab. Infections were mostly polymicrobial; only one case was a monoinfection with Streptococcus. Aerobic bacteria were less frequent in patients who had prior antibiotic therapy (p = 0.015). Fungi were present in 52.9% of cases, with Malassezia (33.3%), Aspergillus (9.8%), and Candida (3.9%) being the most common. Antibiotic resistance was detected in 66.7% of patients, mainly against lincosamides, macrolides and tetracyclines. Fusobacterium showed a 25.9% resistance rate to clindamycin.</p><p><strong>Conclusions: </strong>The microbiome of odontogenic abscesses is polymicrobial, dominated by anaerobic bacteria, and more extensive than indicated by traditional cultural diagnostics. NGS provides detailed pathogen diagnostics, aiding in precise and individualized antibiotic therapy.</p><p><strong>Clinical relevance: </strong>Improved understanding of the bacterial and fungal spectrum, along with current resistance patterns of odontogenic abscesses, is crucial for optimizing treatment outcomes. NGS offers rapid, accurate and detailed microbiome analysis, enhancing patient-specific therapeutic strategies.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"8"},"PeriodicalIF":3.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11631990/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of low-intensity pulsed ultrasound in orthodontic tooth movement and orthodontically induced root resorption in animal and human studies: a systematic review and meta-analysis.","authors":"Yifan Zhao, Qiao Su, Bo Zhang, Kai Xia, Lixing Zhao, Zhihe Zhao","doi":"10.1007/s00784-024-06096-1","DOIUrl":"10.1007/s00784-024-06096-1","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the efficacy of low-intensity pulsed ultrasound (LIPUS) in orthodontic tooth movement (OTM) and orthodontically induced root resorption (OIRR) across animal and human studies.</p><p><strong>Materials and methods: </strong>An electronic search in MEDLINE, Embase, Web of Science, Cochrane Library, National Knowledge Infrastructure, and Wanfang Database up to May 2024 identified 931 records screened using predefined PICOS criteria. 18 animal and 8 human studies met the inclusion criteria, with 12 suitable for meta-analysis. Methodological qualities for animal studies were assessed using the SYRCLE tool and ARRIVE guidelines. For clinical trials, the Cochrane RoB 2.0 tool and ROBINS-I were applied to evaluate the risk of bias in randomized clinical trials (RCTs) and controlled clinical trials (CCTs), respectively. Evidence quality was assessed using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) approach, and quantitative analysis employed RevMan software with an inverse variance method and random effects models for all included studies.</p><p><strong>Results: </strong>Most animal and human studies had a high or unclear risk of bias. LIPUS significantly accelerated OTM in rats, showing increases of 0.08 mm (95% CI, 0.02 to 0.13; P = 0.006), 0.11 mm (95% CI, 0.04 to 0.17; P = 0.001), and 0.11 mm (95% CI, 0.06 to 0.16; P < 0.0001) on days 5, 7, and 14. In clinical trials, LIPUS reduced treatment duration with clear aligners by 352.07 days (95% CI, -524.81 to -179.34; P < 0.0001), but had no significant effect on OIRR (P > 0.05). GRADE analysis indicated very low evidence quality for both outcomes.</p><p><strong>Conclusions: </strong>LIPUS may accelerate OTM but shows weak evidence for alleviating OIRR. More well-designed studies with standardized methodology are needed.</p><p><strong>Clinical relevance: </strong>LIPUS could benefit OTM acceleration, but its effect on OIRR remains inconclusive.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"6"},"PeriodicalIF":3.1,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Smoking status and edentulism among older Chinese: a cohort study.","authors":"Jukun Song, Shengsui Li, Yadong Wu, Zhenglong Tang","doi":"10.1007/s00784-024-06091-6","DOIUrl":"10.1007/s00784-024-06091-6","url":null,"abstract":"<p><strong>Background: </strong>The harmful impact of tobacco smoke on health is widely recognized, linking it to various diseases. However, the link between tobacco smoke and edentulism in China's population hasn't been fully investigated. This study aims to fill this gap by exploring smoking habits and the possible connection between tobacco smoke and edentulism in a nationally representative Chinese cohort.</p><p><strong>Methods: </strong>This study used data from the 2011 China Longitudinal Study of Health and Retirement (CHARLS) and included 17,705 participants aged 45 years and older, and linked with follow-up data (2018). Smoking status (non-smoker, ex-smoker, smoker, pack-years of smoking, age at starting and ceasing smoking) was used as an independent variable, and edentulism was used as a dependent variable. Multivariable logistic regression analysis and curve fitting were used to evaluate the association between smoke status and edentulism. Subgroup analyses were then employed to examine the impact of subgroup factors on the link between smoking status and edentulism.</p><p><strong>Results: </strong>A total of 13,720 people were included in the study, 2,029 of whom were edentulism patients. The association between smoking duration (OR = 1.038, 95%CI = 1.031, 1.045) /Age at quitting smoking (OR = 1.026, 95%CI = 1.013, 1.039)/Smoking pack years (OR = 1.005, 95%CI = 1.002, 1.007) and risk of edentulism was significant, while Age start smoking (OR = 1.003, 95%CI = 0.995, 1.012) and Cigarettes consumed per day (OR = 0.998, 95%CI = 0.991, 1.006) was not associated with risk of edentulism. Compared with non-smokers, current smoker had a higher risk of edentulism (OR 1.274, 95% CI = 1.108, 1.465). Additionally, our results also revealed that there was a nonlinear trend between Smoking duration/Cigarettes consumed per day/Age at quitting smoking/ Age at starting smoking/pack-years of smoking and edentulism (P > 0.05).</p><p><strong>Conclusion: </strong>The research found a significant link between smoking habits and edentulism in nationally representative Chinese population.</p><p><strong>Clinical relevance: </strong>This study in China found a complex link between tobacco use and tooth loss among middle-aged and elderly individuals, highlighting the need for personalized smoking cessation strategies to improve dental health in this population.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"5"},"PeriodicalIF":3.1,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791091","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro bonding strength of denture teeth to denture base in CAD/CAM-milled, 3D-printed and conventional manufacturing processes.","authors":"Marcel Löscher, Sebastian Hahnel, Reinhold Lang, Martin Rosentritt","doi":"10.1007/s00784-024-06099-y","DOIUrl":"10.1007/s00784-024-06099-y","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the survival rates and fracture resistance of dentures made from different teeth (milled, 3D-printed, fabricated), bases (milled, 3D-printed, pressed) and bonding combinations.</p><p><strong>Materials and methods: </strong>Specimens (11 groups, n = 8 per group) were fabricated from combinations with a denture tooth (anterior tooth 21) and a denture base material. The groups consisted of combinations of teeth (6x), denture base materials (5x) and adhesive bonding options (4x). The teeth were printed, milled or prefabricated. The denture base was produced conventionally or was milled or 3D-printed. Two dentures were milled from one industrially produced block. The dentures were subjected to thermal and mechanical loading (TCML) and subsequent fracture test.</p><p><strong>Statistics: </strong>ANOVA, Bonferroni-test, Kaplan-Meier survival, Pearson correlation; α = 0.05.</p><p><strong>Results: </strong>Mean loading cycles varied between 221,869 (8), 367,610 (11), 513,616 (6) 875,371 (3) and 9,000,030 (4). ANOVA revealed significant (p ≤ 0.001) different surviving cycles. Log Rank test showed significantly (p < 0.001) different loading cycles. Fracture force after TCML varied between 129.8 +/- 97.1 N (3) and 780.8 +/- 62.5 N (9). ANOVA comparison revealed significant (p < 0.001) different fracture loadings between the individual systems. Correlation was found between fracture force and loading cycles (0.587, p < 0.001).</p><p><strong>Conclusions: </strong>Different survival rates and fracture forces were found for dentures made of different teeth (milled, 3D-printed, prefabricated), bases (milled, 3D-printed, pressed) and bonding combinations. Milled, pressed and prefabricated systems provided longer survival and fracture force than the other tested systems.</p><p><strong>Clinical relevance: </strong> Optimal tooth-base combinations can help to produce a denture that is stable and resistant during clinical application.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"4"},"PeriodicalIF":3.1,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11624253/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142791090","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of 30% silver diamine fluoride compared to atraumatic restorative treatment in arresting dentin caries lesions in preschoolers: a randomized clinical trial.","authors":"Gabriella Fernandes Rodrigues, Ana Lúcia Vollú, Tamiris Ramos Vargas, Luana Mota Kort Kamp, Thuany da Cunha Costa, Lais Rueda Cruz, Ronir Raggio Luiz, Fernanda Barja-Fidalgo, Andréa Fonseca-Gonçalves","doi":"10.1007/s00784-024-06081-8","DOIUrl":"10.1007/s00784-024-06081-8","url":null,"abstract":"<p><strong>Objective: </strong>To compare the efficacy of silver diamine fluoride (SDF) and atraumatic restorative treatment (ART) in arresting caries lesions. Variables such as treatment time, adverse effects/parental aesthetic perception, anxiety and patients' behavior were also evaluated.</p><p><strong>Materials and methods: </strong>Children (3.53 ± 1.03 years) with dentin caries lesions on the occlusal surface of primary molars were randomized into test (SDF) and control (ART) groups. To determine the presence of caries, dmf-t and ICDAS indexes were used. Caries lesions were also classified according to activity (active or inactive). The time required to perform treatments was recorded and the children's anxiety was assessed by a Facial Image Scale. The adverse events/aesthetic perception were registered by the operator and caregivers. The Frankl Behavioral Scale assessed patients' behavior. The chi-square/Fisher's exact and Mann-Whitney tests were used for comparisons between the groups.</p><p><strong>Results: </strong>Of the 118 participants who received treatment (SDF, n = 59; ART, n = 59), after 12-month follow-up, 91.5% (43/47) of caries lesions in the SDF and 90.2% (46/51) in the ART group were arrested (p = 1.000). After 24 months, 72% (18/25) were arrested in the SDF group and 95.2% (20/21) in the ART. The treatment times were 6.08 ± 1.72 and 13.58 ± 4.83, for SDF and ART, respectively (p < 0.001). No statistically significant difference of adverse effects, aesthetic perception, anxiety, and patients' behavior were found between the groups.</p><p><strong>Conclusions: </strong>SDF was similar to ART in arresting caries lesion but required less time for treatment. The anxiety, adverse effects/aesthetic perception and patients' behavior were also similar between the groups.   CLINICAL RELEVANCE: The use of SDF may be a faster and less invasive alternative for the treatment of caries lesions. Clinical trial registration number and date of registration: NCT03063307. September 2016.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"3"},"PeriodicalIF":3.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of Porphyromonas gingivalis with esophageal squamous cell carcinoma: a systematic review.","authors":"Avideh Maboudi, Kaveh Hajifathalian, Zeynab Negahban, Anahita Lotfizadeh, Mahmood Moosazadeh, Abbas Mesgarani, Tahereh Molania","doi":"10.1007/s00784-024-06094-3","DOIUrl":"https://doi.org/10.1007/s00784-024-06094-3","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to assess the correlation of Porphyromonas gingivalis (P. gingivalis) with esophageal squamous cell carcinoma (ESCC).</p><p><strong>Materials and methods: </strong>This systematic review evaluated case-control, cohort, and cross-sectional studies published between 1990 and 2024 that compared ESCC patients and healthy controls regarding the presence of P. gingivalis, risk of ESCC development, overall survival rate and prognosis of ESCC, lymph node metastasis, clinical stage of the disease, cancer cell proliferation and migration, efficacy of chemotherapy, invasion depth, and cell differentiation. Searching process was conducted in Web of Science, Scopus, PubMed, and Cochrane Library. The quality of included studies was assessed by the Newcastle Ottawa scale (NOS).</p><p><strong>Results: </strong>Of 270 articles, 11 underwent a systematic review with NOS scores ranging from 7 to 9. 5 studies found a correlation between P.gingivalis and overall survival rate of ESCC patients (P < 0.05). 5 studies found a significant correlation between P.gingivalis count and the risk of ESCC development (P < 0.05). 2 studies showed a significant correlation between lymph node metastasis and 3 studies showed a significant correlation between clinical TNM stage and P.gingivalis (P < 0.05).</p><p><strong>Conclusions: </strong>High P. gingivalis count increases the risk of development of ESCC, lymph node metastasis, progression to stages 3 and 4, proliferation and migration of cancer cells, and depth of invasion, decreases the overall survival rate and prognosis of the disease, and efficacy of chemotherapy, and results in poorer differentiation of cells.</p><p><strong>Clinical relevance: </strong>According to our findings, dental clinicians and patients should be informed about the significance of oral hygiene and its relationship with ESCC to prevent future life-threatening diseases.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"1"},"PeriodicalIF":3.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of exfoliative cytology in diagnosis of oral lesions.","authors":"Paulo Sergio Souza Pina, Alvaro Tolentino Mendes, Luciana Correa, Fabio Luiz Coracin, Suzana Cantanhede Orsini Machado de Sousa","doi":"10.1007/s00784-024-06080-9","DOIUrl":"https://doi.org/10.1007/s00784-024-06080-9","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to evaluate the use of oral exfoliative cytology and highlight its limited effectiveness in diagnosing oral diseases.</p><p><strong>Materials and methods: </strong>A total of 1000 consecutive cases of oral cytology were retrieved from the files of an Oral Pathology Service, comprising the period between January 2002 and December 2022. Patient data and clinical details of the lesions were collected, and all slides were reviewed. Categorical data were presented in absolute and relative frequency (%), while numerical data were expressed as the median with minimum and maximum values. The Chi-square (X²) test was employed for frequency comparisons, with a significance level of 5%.</p><p><strong>Results: </strong>Men constituted 64.6% (n = 646) of the cases, with a statistically significant predominance of white individuals (69.4%; n = 694). Of the 1000 evaluated cases, 87.8% (n = 878) were graded using Papanicolaou staining. Regarding provisional diagnoses, most clinicians (79.1%) suspected fungal lesions (n = 817). Analysis of the agreement between provisional and final cytological diagnoses revealed a statistically significant disagreement.</p><p><strong>Conclusions: </strong>This work reinforces the limited use of exfoliative cytology in diagnosing oral lesions.</p><p><strong>Clinical relevance: </strong>Exfoliative oral cytology should be restricted to specific cases, particularly for diagnosing fungal disease, and occasionally when oral cancer is suspected, but a biopsy cannot be performed at that time.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"2"},"PeriodicalIF":3.1,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor in response to \"Microbial colonization in the partially exposed nonabsorbable membrane during alveolar ridge preservation\" (Braz et al., clinical oral Investigations, https://doi.org/10.1007/s00784-024-05763-7.).","authors":"Eliane Porto Barboza, Beatriz Panariello","doi":"10.1007/s00784-024-06079-2","DOIUrl":"10.1007/s00784-024-06079-2","url":null,"abstract":"<p><strong>Objective: </strong>This letter addresses the recent study by Braz et al. published in Clinical Oral Investigations in 2024 ( https://doi.org/10.1007/s00784-024-05763-7 ), which reported that intentionally exposed d-PTFE membranes modulate microbial colonization in alveolar ridge preservation (ARP) sites, creating a more homogeneous and anaerobic community on both the inner and outer surfaces of the membrane.</p><p><strong>Materials and methods: </strong>We argue that the study's methodology may have skewed the results, particularly the inclusion of both intact and damaged extraction sockets (with loss of the buccal wall) and the absence of bone grafting.</p><p><strong>Results: </strong>The absence of bone graft might have contributed to membrane dislodgement and increased microbial contamination rather than the membrane's inherent properties.</p><p><strong>Conclusion: </strong>This critique is significant because it challenges the conclusion that the d-PTFE membrane itself is responsible for microbial colonization, highlighting the need to consider extrinsic factors and study design limitations.</p><p><strong>Clinical relevance: </strong>Our discussion aims to enhance the understanding of microbial dynamics in ARP procedures and emphasizes the need for caution when interpreting the study's findings, given the context of established clinical practices and existing evidence.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"28 12","pages":"685"},"PeriodicalIF":3.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of reactive soft tissue for alveolar ridge preservation: a prospective cohort study.","authors":"Shuang Jiang, Rui Sheng, Quan Yuan, Xingmei Yang","doi":"10.1007/s00784-024-06073-8","DOIUrl":"10.1007/s00784-024-06073-8","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to investigate the effect of alveolar ridge preservation (ARP) sealing using reactive soft tissue (RST) or collagen sponge (CS), in combination with deproteinized bovine bone mineral (DBBM), for teeth with bone deficiency.</p><p><strong>Materials and methods: </strong>In this study, 44 patients were recruited. During ARP therapy, RST or CS was applied for socket sealing. Horizontal and vertical bone dimensions were assessed before extraction (T0) and 6 months after ARP (T2). Modified Masse healing index (HI) was recorded to evaluate the soft tissue healing at 14 days after ARP (T1) and T2. Keratinized mucosa width (KMW) was measured at T0 and T2. Biopsies were collected during implant placement for histological analysis.</p><p><strong>Results: </strong>This study was finished by 40 patients. Horizontal ridge gains at 1, 3, and 5 mm below the crest were comparable in RST (4.37/5.57/4.16 mm) and CS (3.57/4.66/2.97 mm) groups. Similar vertical bone gains at both buccal and lingual sides were observed in RST and CS groups. Notably, the sockets in the RST group exhibited a significantly better early healing score (6) at T1 relative to the CS group (7) (p = 0.003). There was no significant difference in KMW changes as well as new bone proportion between the groups.</p><p><strong>Conclusions: </strong>RST and CS, when combined with DBBM, both effectively reduced ridge resorption in sockets with bone deficiency. RST demonstrated a more favorable effect on the early healing of sockets.</p><p><strong>Clinical relevance: </strong>RST is a promising socket sealing material in ARP, which reduces bone resorption, and promotes soft tissue healing.</p><p><strong>Trial registration: </strong>Clinical trial registration Number: ChiCTR2200061459.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"28 12","pages":"684"},"PeriodicalIF":3.1,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142779486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of submucosal dexamethasone on postoperative pain, swelling and trismus after periodontal surgery: a randomized clinical study.","authors":"Dicle Altindal, Anas Alsafadi, Basem Alshujaa, Ahmet Cemil Talmac, Bilal Ege, Metin Calisir, Nazli Zeynep Alpaslan","doi":"10.1007/s00784-024-06076-5","DOIUrl":"10.1007/s00784-024-06076-5","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study is to evaluate the effectiveness of submucosal 8 mg (2 mL) dexamethasone (DEX) on postoperative pain, swelling, chewing efficiency, trismus, healing, and discomfort after periodontal flap surgery (PFS).</p><p><strong>Methods: </strong>In this randomized controlled split-mouth study, 25 patients underwent PFS in the mandible, whereby postoperative, submucosal DEX was injected to the surgical field to the test group and submucosal normal saline was applied to the control group. Pain was evaluated using the Visual Analogue Scale (VAS) and the 101-point numeric rate scale in the first 8 h after PFS and on the 2nd, 3rd, 4th, and 7th days, whereas swelling, chewing efficiency, trismus, healing, discomfort and analgesic consumption were evaluated preoperatively on the 1st, 2nd and 7th days.</p><p><strong>Results: </strong>In the intergroup evaluation, the VAS-7th hour value of the test group was lower than the control group(p < 0.05). On the 1st day, it was observed that there was less swelling and more chewing efficiency in the test group than in the control group(p < 0.05). When time-dependent changes were examined, the decrease in mouth opening due to trismus in the control group was greater than that in the test group on the 1st and the 2nd days compared to the preoperative period(p < 0.05). Finally, postoperative healing, discomfort, and analgesic consumption were similar between groups.</p><p><strong>Conclusion: </strong>Within the limits of this study, the submucosal DEX may be an effective protocol in the management of pain, swelling, and trismus after PFS.</p><p><strong>Clinical relevance: </strong>Our findings shed light on the possible effects of DEX after PFS.</p><p><strong>Trial registration: </strong>This study was registered on ClinicalTrials.gov (NCT06119893).</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"28 12","pages":"681"},"PeriodicalIF":3.1,"publicationDate":"2024-12-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766757","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}