Clinical Oral Investigations最新文献

{"title":"Structural response of mandibular first molars in the presence of proximal contacts: finite element analysis with antagonist teeth and alternative loading applications.","authors":"Saúl Dorado, Jesús R Jimenez-Octavio, Paula Riaza, Ove A Peters, Ana Arias","doi":"10.1007/s00784-025-06290-9","DOIUrl":"https://doi.org/10.1007/s00784-025-06290-9","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the mechanical responses of a mandibular molar under functional loads using antagonist teeth and different loading applications and configurations.</p><p><strong>Methods: </strong>A cone-beam computed tomography of a human mandible and maxilla was used to build 16 different three-dimensional models, including four mandibular configurations [single-tooth model (first mandibular molar-M), and inclusion of mesial (mM), distal (Md) or both proximal contacts (mMd)] and occlusal load applications either with antagonist teeth or alternative Finite Element (FE) models [point load (PL), distributed surface load (SL) and rigid metal sphere (MS)]. FE analysis was performed. Equivalent von Mises (VM) stress was calculated along the entire dentin and periodontal ligament of the first mandibular molar. Maximum VM stresses were compared among the different mandibular configurations and loading applications.</p><p><strong>Results: </strong>The highest and lowest VM stress at 50 and 100 N corresponded respectively to the single-tooth SL model (5.78 and 11.5 MPa) and to occlusal load application with antagonist teeth and proximal contacts (2.08 and 3.58 MPa). Maximum VM stresses were consistently located at the cervical area of the mesial root and decreased when adjacent teeth were present.</p><p><strong>Conclusions: </strong>Highest stresses are located in the cervical area of the mesial root of mandibular molars, but the biomechanical behavior depends on the presence of proximal contacts and the loading methodologies used. Single-tooth models represent the worst structural scenario.</p><p><strong>Clinical relevance: </strong>Incorporating antagonist teeth and proximal contacts into FE models enhances the biofidelity of dental biomechanics simulations, enabling more accurate extrapolation to clinical conditions.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"214"},"PeriodicalIF":3.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reliability of Ashley Howes analysis in evaluating expansion potential: a cone beam computed tomography study.","authors":"Bhavika Agrawal, Bhadrinath Srinivasan, Sridevi Padmanabhan","doi":"10.1007/s00784-025-06287-4","DOIUrl":"https://doi.org/10.1007/s00784-025-06287-4","url":null,"abstract":"<p><strong>Objectives: </strong>In recent times orthodontic treatment trends has swung towards non -extraction treatment. The Ashley Howes analysis evaluates the possibility of expansion based on the apical base. The transversal arch expansion potential of the mandibular arch also plays a role when considering maxillary expansion and should not be disregarded. Although, meant for both maxillary and mandibular arches, the subsequent focus of the analysis had mostly been in the maxillary arch. The aim of this study was to correlate the Ashley Howes analysis with buccal bone thickness at different vertical levels, tooth inclination and apical base width at the region of first premolars measured on CBCT images in both maxillary and mandibular arches.</p><p><strong>Materials and methods: </strong>This retrospective study design evaluated pretreatment maxillary and mandibular study models and CBCTs of 84 patient records selected for the study. Based on the Ashley Howes analysis they were categorized into Group I (expansion not possible) and Group II (Expansion possible). The independent t-test was used for intergroup comparisons of CBCT parameters and Pearson correlation test was used to assess the relationship between expansion potential and CBCT parameters.</p><p><strong>Results: </strong>In both maxillary and mandibular arches, Group II was characterized by greater buccal bone thickness at all vertical levels, greater apical base width and less premolar inclination when compared to groups without expansion potential although these differences were not statistically significant except for the mandibular apical base width. Although correlation between expansion potential and buccal bone thickness was not statistically significant in both the arches, it showed a positive correlation to apical base width and a negative correlation with premolar inclination in the mandibular arch.</p><p><strong>Conclusion: </strong>The Ashley Howes analysis appears to reflect the relevant differences between extraction and non-extraction cases particularly in the mandibular arch.</p><p><strong>Clinical relevance: </strong>Ashley Howes analysis could still be an effective tool in evaluating expansion potential and should be performed in both maxillary and mandibular arches.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"211"},"PeriodicalIF":3.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical application of customized total temporomandibular joint prosthesis by 3D printing: a five-year follow-up study.","authors":"Qingyu Xu, Liang Huo, Xiang Wei, Zixian Jiao, Zixiang Han, Lingtong Bu, Minjie Chen, Jisi Zheng, Chi Yang","doi":"10.1007/s00784-025-06260-1","DOIUrl":"https://doi.org/10.1007/s00784-025-06260-1","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to evaluate the clinical efficacy and stability of customized total temporomandibular joint (TMJ) prosthesis by 3D printing from TMJ Yang's prosthesis system after five-years follow-up.</p><p><strong>Materials and methods: </strong>This prospective single-center case series study recruited patients required total TMJ prosthesis replacement from March 2016 to September 2022. Patient information was collected and followed up at 1 month, 3 months, 6 months, 1 year, 2 years and 5 years post-surgery. Using CT and panoramic scans to evaluate the prosthesis' position and bone integration. Pain, diet and mandibular function were evaluated by VAS score, and maximum interincisal opening, mouth opening deviation and mandibular maximum forward and lateral movement were recorded. Statistical analyses include descriptive statistics for demographic characteristics and paired t-tests and ANOVA for quantitative analysis.</p><p><strong>Results: </strong>49 consecutive patients with an average age of 52.88 ± 13.78 years were included. The mean follow-up time was 5.00 ± 1.88 years. There were no postoperative infections, and the wound healed well. Patients' postoperative facial shape and occlusion remained unchanged except for one patient improved the facial shape by second-stage genioplasty. The position of the prosthesis was stable and the bone integration was satisfactory. After surgery, pain, mandibular function, and diet improved significantly (P < 0.05) and remained stable 1 year later. The maximum interincisal opening increased (P < 0.05), with mouth opening deviation and movement on the affected side similar to preoperative levels, but movement on the unaffected side and forward movement decreased slightly.</p><p><strong>Conclusions: </strong>The customized total TMJ prosthesis by 3D printing from TMJ Yang's prosthesis system is safe, stable and effective during five years' clinical application.</p><p><strong>Clinical relevance: </strong>This study provides a new, safe and effective prosthesis option for temporomandibular joint reconstruction.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"210"},"PeriodicalIF":3.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735916","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does the early loss of primary teeth impact the oral health-related quality of life of children? A systematic review and meta-analysis.","authors":"Aurélio de Oliveira Rocha, Michely Cristina Goebel, Karina Cardoso, Lucas Menezes Dos Anjos, Mariane Cardoso, Filipe Colombo Vitali, Pablo Silveira Santos","doi":"10.1007/s00784-025-06291-8","DOIUrl":"https://doi.org/10.1007/s00784-025-06291-8","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic review aimed to assess the impact of early loss of primary teeth on children's Oral Health-Related Quality of Life (OHRQoL).</p><p><strong>Materials and methods: </strong>Electronic searches were conducted in eight databases, including grey literature, up to February 2025. The PECOS strategy was employed to identify studies evaluating the impact of early loss of primary teeth on children's OHRQoL. Studies evaluating permanent tooth loss were excluded. The risk of bias in the included studies was evaluated using Joanna Briggs' checklists for observational studies and the Cochrane RoB 2 tool for randomized clinical trials. A random-effect meta-analysis was conducted comparing the mean scores of OHRQoL questionnaires between children with and without early loss of primary teeth. The certainty of evidence was assessed using the GRADE approach.</p><p><strong>Results: </strong>Five studies were included in the systematic review and three in the meta-analysis. Three studies fulfilled all items of the risk of bias checklists. The meta-analysis revealed that children with early loss of primary molars scored an average of 14.38 points higher on the OHRQoL questionnaire (95% CI: 2.13-26.64) compared to those without early primary molar loss, indicating a poorer OHRQoL. The certainty of evidence was considered very low.</p><p><strong>Conclusions: </strong>The early loss of primary molars negatively impacted the OHRQoL of schoolchildren aged 8 to 10 years, as evidenced by higher OHRQoL scores.</p><p><strong>Clinical relevance: </strong>The findings directly affect clinical practice, indicating that early loss of primary molars is associated with poorer OHRQoL in children aged 8 to 10 years. This information is valuable for dentists, pediatricians, and other healthcare professionals involved in children's oral health care.</p><p><strong>Registration: </strong>This systematic review was registered under the protocol registration code CRD42023439971.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"213"},"PeriodicalIF":3.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Intraoral Mandibular Osteotomy For Set-Back Surgery In Complex Mandibular Anatomy.","authors":"Mohammed Omara, Sherif Ali, Yassin Salah Alian, Nehal Ibrahim Shobair","doi":"10.1007/s00784-025-06239-y","DOIUrl":"10.1007/s00784-025-06239-y","url":null,"abstract":"<p><strong>Objective: </strong>Complex mandibular anatomy including rolled-out inferior mandibular border, thin rami with cortically adherent inferior alveolar nerve (IAN) complicate the application of the current mandibular osteotomies. This study aims to introduce an intraoral Inverted-L Ramus Osteotomy (ILRO) modified with IAN lateralization and intra-canal osteotomy for management of complex mandibular anatomical variations during mandibular setback surgery.</p><p><strong>Patients and methods: </strong>This prospective study included 20 skeletal class III patients (mean age: 21.6 ± 3.3 years) with complex mandibular anatomy indicated for mandibular setback surgery (mean setback: 6.05 ± 1.1 mm). Preoperative CBCT imaging, digital planning, and fabrication of cutting / drilling guides were performed. Surgery involved mandibular setback through the application of the ILRO modified with nerve lateralization and intra-canal osteotomy. IAN function evaluated preoperatively at intervals up to one year postoperatively. Data on bad splits and surgical duration were also analyzed.</p><p><strong>Results: </strong>The mean surgical duration was 2.26 ± 0.21 h, with bilateral IAN exposure completed in 11 ± 3.2 min per side. All 40 osteotomy sites were separated without bad splits. Neurosensory deficits were observed in 90% of patients at two months, decreasing to 35% at six months and 5% at one year.</p><p><strong>Conclusion: </strong>The introduced osteotomy overcomes the limitations of the traditional mandibular osteotomies in dealing with mandibular complex anatomy with adequate IAN protection and split segments integrity during mandibular setback surgery.</p><p><strong>Clinical relevance: </strong>The introduced osteotomy provides a safe alternative to the current mandibular osteotomies utilized in mandibular setback surgery.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"215"},"PeriodicalIF":3.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11953089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implant placement-associated tissue swelling: a digital three-dimensional and patient-based assessment.","authors":"Vrisiis Kofina, Juan Valencia Rincon, Swati Y Rawal, Andrew R Dentino, Shengtong Han, Dimitris N Tatakis","doi":"10.1007/s00784-025-06284-7","DOIUrl":"https://doi.org/10.1007/s00784-025-06284-7","url":null,"abstract":"<p><strong>Objectives: </strong>There is scarce evidence on immediate soft tissue and patient-reported outcome measures (PROMs) following implant surgery. This prospective study aimed to quantify post-implant placement intraoral swelling and to correlate it with PROMs.</p><p><strong>Materials and methods: </strong>Twenty-six patients undergoing standardized single implant placement (two-stage protocol) were recruited. Soft tissue swelling was recorded by intraoral scans immediately pre-surgery (PS) and post-operatively (IP), and at 2 (2d), 7 (7d) and 14 days (14d) and 2 months (2 m). Ridge width, height, and volume changes from IP were recorded. PROMs (pain, swelling, difficulty of mouth opening, and OHIP-14) were recorded pre- and post-operatively.</p><p><strong>Results: </strong>Ridge width (1.9±0.04 mm), height (1.4 ±0.02 mm) and volume (37.8±0.8%) peaked on 2d (p < 0.0001 vs. IP for all). Width returned to IP levels by 7d (p = 0.43; 7d vs. IP), and height and volume between 14d and 2 m (p≤0.002; all time points vs. IP). Patient-reported pain, swelling and difficulty of mouth opening exhibited a similar trajectory, while OHIP-14 values improved until 2 m (p < 0.0001 vs. PS). Ridge width differences IP/2d were correlated with patient-reported swelling (ρ = 0.53-0.54) and difficulty of mouth opening (ρ = 0.43-0.45) at 2d.</p><p><strong>Conclusion: </strong>Following implant placement, soft tissue exhibits maximal swelling at 2 days and patients experience the most significant pain, swelling and difficulty of mouth opening at the same time.</p><p><strong>Clinical relevance: </strong>The swelling timing and magnitude findings of the present study may assist clinicians when delivering and modifying temporary restorations (safety distance between restoration/tissue), as well as managing patient pain and swelling expectations following implant placement surgery.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"212"},"PeriodicalIF":3.1,"publicationDate":"2025-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735935","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of root canal therapy in auto-transplanted third molars: a systematic review, meta-analysis and case series report.","authors":"Xin Yang, Lu Yin, Danyang Guo, Junzhou Chi, Shaozhen Ma, Juanxiu Liu, Yue Chen, Shunyun Luo, Kun Tian","doi":"10.1007/s00784-025-06264-x","DOIUrl":"10.1007/s00784-025-06264-x","url":null,"abstract":"<p><strong>Objectives: </strong>The existing literature indicates insufficient conclusive evidence regarding the efficacy of root canal therapy (RCT) in conjunction with third molar autologous tooth transplantation (ATT). This systematic review aims to evaluate the long-term survival rates and complications associated with this method.</p><p><strong>Materials and methods: </strong>A comprehensive search was conducted across multiple databases, including PubMed, EMBASE (OVID), Web of Science (WOS), EBSCO, SpringerLink, Oxford, and ScienceDirect. This systematic review adhered to the guidelines set forth by the PRISMA and was registered in PROSPERO (CRD42024585817). This study calculated pooled survival rates, root resorption rates, and overall survival metrics. Subgroup analyses were performed to investigate the influence of follow-up duration, sample size, timing of endodontic treatment, and endodontic treatment on outcomes. Statistical significance was determined using an alpha value of 0.05, with 95% confidence intervals (CI) reported for pooled estimates. Heterogeneity was assessed using the I² statistic and Cochran's Q test.</p><p><strong>Results: </strong>Among the 17 included studies, the follow-up period ranged from 1 to 29 years. After excluding two studies with 100% survival rates, the overall 1-year survival rate was 96% (P < .0001). Studies with mixed samples showed a higher 20-year survival rate compared to those exclusively involving third molars (46.2% vs. 41.3%; P = 0.029). RCT significantly improved survival and success rates in third molar autotransplantation, though heterogeneity varies across studies. The success rate reflects the completeness of treatment and indicates the restoration of tooth function, whereas the survival rate focuses more on the long-term retention of the tooth. The higher risk difference (RD) observed in the RCT group suggests that RCT enhances both survival and success rates. This finding highlights the potential role of RCT in enhancing the success of ATT. However, significant heterogeneity was observed across studies (I² = 73%), and the difference between the two groups were not statistically significant (P = 0.37, I² = 0%). These results may be influenced by follow-up duration, timing of endodontic treatment, and sample size. Therefore, the conclusions should be read with caution.</p><p><strong>Conclusion: </strong>ATT of third molars with intact root formation represents a reliable approach for the replacement of missing teeth, demonstrating a high survival rate. Furthermore, RCT is associated with reduced complication rates and enhanced long-term survival.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"209"},"PeriodicalIF":3.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11950017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Atherogenic index of plasma and periodontitis in non-dyslipidemic adults: a nationwide study.","authors":"Tae-Gu Kang, Na-Yeong Kim, Sang-Min Lee, Ki-Ho Chung","doi":"10.1007/s00784-025-06277-6","DOIUrl":"https://doi.org/10.1007/s00784-025-06277-6","url":null,"abstract":"<p><strong>Background: </strong>This study investigated the association between atherogenic index of plasma (AIP)-related indices and periodontal diseases in adults without dyslipidemia using healthcare big data from Korea National Health & Nutrition Examination Survey (KNHANES).</p><p><strong>Methods: </strong>This cross-sectional study analyzed data from 16,343 adults in the 2010-2018 KNHANES. Periodontal status was assessed using the Community Periodontal Index (CPI), while AIP-related indices, including AIP, triglycerides (TG), and high-density lipoprotein cholesterol (HDL), were evaluated. Statistical analyses included chi-square tests and t-tests for group comparisons, multivariate logistic regression to calculate odds ratios (ORs) for periodontitis risk, and receiver operating characteristic (ROC) curve analysis to assess diagnostic accuracy.</p><p><strong>Results: </strong>Higher AIP-related indices (excluding HDL) were associated with an increased risk of periodontitis, while lower HDL levels also correlated with higher disease prevalence. (p < 0.0001). The AIP adjusted with waist-to-height ratio (AIP*WHtR) exhibited the highest diagnostic accuracy among all indices analyzed, with the highest area under the ROC curve (AUC), whereas HDL showed the lowest predictive value.</p><p><strong>Conclusions: </strong>AIP-related indices were significantly associated with periodontitis in adults without dyslipidemia, with higher AIP-related indices linked to an increased risk of periodontitis. Among these, AIP*WHtR exhibited the highest diagnostic accuracy. However, due to the cross-sectional study design, causality cannot be determined. Thus, longitudinal studies are required to validate the predictive value of AIP-related indices for periodontitis risk.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"208"},"PeriodicalIF":3.1,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718261","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of the accuracy of the image registration methods for the impressions of edentulous jaws.","authors":"Mingli Liu, Xiaotong Li, Zhe Qu","doi":"10.1007/s00784-025-06187-7","DOIUrl":"10.1007/s00784-025-06187-7","url":null,"abstract":"<p><strong>Objective: </strong>The aim of present study was to investigate the accuracy of two registration methods, best fit alignment and manual multi-point alignment followed by global registration, used in edentulous jaw impressions.</p><p><strong>Methods: </strong>Traditional complete denture impressions were taken via two methods: open-mouth and closed-mouth methods. The edentulous impression models, including maxilla:14 pairs and mandible:12 pairs, were scanned in the model scanner and saved in STL format. In the reverse engineering software Geomagic Control 2014, two registration methods, namely, best fit alignment and manual multi-point alignment combined with global registration, were used independently to align the open-mouth and closed-mouth impressions of the same patient, and the 3-dimensional (3D) deviation between the reference and test models was recorded. SPSS26.0, paired t test, significance criterion two-sided α = 0.05.</p><p><strong>Results: </strong>The nominal value threshold area was less in the best fit alignment group (maxilla 48.58%, mandible 44.16%) than in the manual + global registration group (maxilla 70.55%, mandible 66.27%), maxilla P = 0.000 < 0.05, mandible P = 0.014 < 0.05. The root mean square (RMS), average positive deviation and average negative deviation of the best fit alignment group were greater than those of the manual + global registration group, there were significant differences in the maxillary (P < 0.05), but not significant difference in the mandibular (P > 0.05).</p><p><strong>Conclusion: </strong>The manual multi-point combined global registration method is more accurate than the best fit alignment used in the registration of edentulous jaw impressions and is more effective for the maxilla.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"207"},"PeriodicalIF":3.1,"publicationDate":"2025-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947021/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143729024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary trimethylamine N-oxide: a novel non-invasive marker for periodontal inflammation.","authors":"Ceyhan C Serdar, Zeliha Guney, Nur Balci, Sema M Altingoz, Muhittin A Serdar, Sivge Kurgan","doi":"10.1007/s00784-025-06295-4","DOIUrl":"10.1007/s00784-025-06295-4","url":null,"abstract":"<p><strong>Objectives: </strong>Trimethylamine N-oxide (TMAO) has been implicated in systemic inflammatory pathways, emphasizing its potential as a biomarker. Elevated plasma TMAO levels have been associated with increased oxidative stress, leading to higher plasma concentrations of TNF-α, a key pro-inflammatory cytokine. Given this systemic inflammatory linkage, saliva-a non-invasive diagnostic medium-offers a unique opportunity to reflect both local and systemic inflammatory changes. This study aimed to evaluate the alterations in salivary and serum TMAO levels in periodontitis and assess the diagnostic potential of salivary TMAO as an indicator of periodontal inflammation.</p><p><strong>Materials and methods: </strong>Twenty-four patients with periodontitis (Stage III Grade B) and 24 healthy controls were included. Clinical parameters (probing depth (PD), plaque index (PI), bleeding on probing (BOP), and clinical attachment loss (CAL)) were recorded. TMAO levels in saliva and serum were measured using liquid chromatography-mass spectrometry (LC-MS/MS), and TNF-α levels were assessed using Enzyme-Linked ImmunoSorbent Assay (ELISA).</p><p><strong>Results: </strong>Salivary and serum TMAO levels and salivary TNF-α levels were significantly higher in the periodontitis group (p = 0.003, p = 0.004, and p = 0.031, respectively). Salivary TMAO showed positive correlations with periodontal parameters (p < 0.05) and salivary TNF-α levels. A significant positive correlation was also observed between salivary and serum TMAO levels (p < 0.001). Salivary TMAO was the accurate biomarker in differentiating between periodontitis and controls (sensitivity = 0.583, specificity = 0.833, AUC = 0.747).</p><p><strong>Conclusions: </strong>Salivary TMAO demonstrates potential as a non-invasive marker for periodontitis, showing correlations with clinical parameters and inflammatory markers. These findings suggest that TMAO may reflect both local and systemic inflammatory states associated with periodontal disease.</p><p><strong>Clinical relevance: </strong>Salivary TMAO may serve as a potential non-invasive indicator of periodontitis, as it reflects aspects of both local and systemic inflammation, offering insights into periodontal disease status.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"206"},"PeriodicalIF":3.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}