Clinical Oral Investigations最新文献

{"title":"Correction to: Genetic risk factors for periodontitis: a genome-wide association study using UK Biobank data.","authors":"Chenyi Gao, Mark M Iles, David Timothy Bishop, Harriet Larvin, David Bunce, Bei Wu, Huabin Luo, Luigi Nibali, Susan Pavitt, Jianhua Wu, Jing Kang","doi":"10.1007/s00784-025-06286-5","DOIUrl":"10.1007/s00784-025-06286-5","url":null,"abstract":"","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"198"},"PeriodicalIF":3.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of an artificial intelligence-based model in diagnosing periodontal radiographic bone loss.","authors":"Luanny de Brito Avelino Cassiano, Jordão Paulino Cassiano da Silva, Agnes Andrade Martins, Matheus Targino Barbosa, Katryne Targino Rodrigues, Ádylla Rominne Lima Barbosa, Gabriela Ellen da Silva Gomes, Paulo Raphael Leite Maia, Patrícia Teixeira de Oliveira, Maria Luiza Diniz de Sousa Lopes, Ivanovitch Medeiros Dantas da Silva, Ana Rafaela Luz de Aquino Martins","doi":"10.1007/s00784-025-06283-8","DOIUrl":"https://doi.org/10.1007/s00784-025-06283-8","url":null,"abstract":"<p><strong>Objective: </strong>To develop an artificial intelligence model based on convolutional neural network for detecting and measuring periodontal radiographic bone loss (RBL).</p><p><strong>Materials and methods: </strong>Keypoint annotations were carried out in 595 digital bitewing radiographic images using a Computer Vision Annotation Tool. The dataset was splitted: 416 of these images were trained using the You Only Look Once version 8 architecture with pose estimation (YOLO-v8-pose), 119 images were destined for the validation set, and 60 images were used for the test set, resulting in a model capable of detecting keypoints related to the cementoenamel junction (CEJ) and alveolar bone crest (ABC). In order to evaluate the performance of the obtained model, the following metrics were analyzed: F1-Score, precision, sensitivity and mean average precision (mAP). Then, an algorithm was implemented to measure the RBL by calculating the Euclidean distance between CEJ and ABC.</p><p><strong>Results: </strong>The model achieved an F1-Score of 66,89%, precision of 61,1%, a sensitivity of 73,9% and an mAP of 73.8%.</p><p><strong>Conclusions: </strong>The developed model and its algorithm for identifying and measuring periodontal radiographic bone loss demonstrated promising performance, thereby presenting a potential tool for assisting in periodontal diagnosis. Further studies comparing the developed model with manual measurements performed by specialists are necessary for its validation.</p><p><strong>Clinical relevance: </strong>Applying artificial intelligence in clinical dental practice can support diagnosis, streamline clinical workflows, and inform treatment planning, representing a significant advancement in dental automation.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"195"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mussel-inspired remineralizing agent: effects on morphology and permeability of dentin after erosion and abrasion cycling protocol.","authors":"Joyce Figueiredo de Lima Marques, Milagros Falcon Aguilar, Waldemir Francisco Vieira-Junior, Vanessa Gallego Arias Pecorari, Klaus Rischka, Flávio Henrique Baggio Aguiar","doi":"10.1007/s00784-025-06276-7","DOIUrl":"https://doi.org/10.1007/s00784-025-06276-7","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effects on morphology and permeability of dentin after an erosive and abrasive cycling protocol followed by treatment with an experimental solution containing dopamine.</p><p><strong>Materials and methods: </strong>Dentin hypersensitivity was simulated in human dentin discs by applying EDTA for 5 min. After assessing maximum dentin permeability (initial), specimens were randomly allocated into four groups: distilled water (control), NaF 0.05% solution, a commercial solution (Colgate^® Sensitive Pró-AlívioTM), or an experimental solution containing dopamine and laccase (n = 15). An erosive/abrasive cycling protocol was applied, including 0.3% citric acid for 2 min 4x/day, brushing for 5 s 2x/day, treatments for 5 min 2x/day. Dentin permeability was reassessed (final). Percentage permeability for each time point was calculated relative to maximum permeability (%Lp) and analyzed by generalized linear mixed models (α = 0.05). Surface effects were analyzed by scanning electron microscopy.</p><p><strong>Results: </strong>A significant reduction in permeability occurred in all groups post-cycling and treatment (p < 0.05), with no significant differences between groups (p = 0.6082). All groups exhibited sparse surface deposits, with few occluded tubules. Tubules appeared smaller in diameter in the Colgate^® and experimental solution groups, while distilled water and NaF groups showed more open tubules.</p><p><strong>Conclusion: </strong>In this model, dopamine demonstrated a limited effect, showing no significant protection of the dentin surface or reduction in permeability, similar to the other tested solutions.</p><p><strong>Clinical relevance: </strong>Changes in the habits of modern society have increased the prevalence of tooth wear and dentin hypersensitivity. In this context, it is essential to develop not only new active ingredients to prevent or minimize mineral loss but also new treatment methods.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"193"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of photobiomodulation and selective caries removal in deep cavities on postoperative sensitivity, pulp vitality and dentin neoformation: randomized clinical trial and tomographic evaluation.","authors":"Thais de Mendonça Petta, Adan Lucas Pantoja de Santana, Ana Karoline Oliveira Nunes, Rayka Nohara Furtado Gomes da Silva, Giovana Monteiro Teles, Helder Henrique Costa Pinheiro, Marcia Martins Marques, Roberta Souza D'Almeida-Couto","doi":"10.1007/s00784-025-06263-y","DOIUrl":"https://doi.org/10.1007/s00784-025-06263-y","url":null,"abstract":"<p><strong>Objectives: </strong>This randomized clinical trial aimed to evaluate the effect of selective caries removal in deep cavities of posterior teeth associated or not by photobiomodulation (PBM) on postoperative sensitivity, pulp vitality, and dentin neoformation.</p><p><strong>Materials and methods: </strong>Twenty seven permanent molars with deep Class I cavities were allocated into three groups (n = 9): selective caries removal (Control), selective caries removal followed by infrared (IR; 810 nm) or red (R; 660 nm) laser irradiation. After the cavities were restored with a two-step self-etch adhesive and composite layers, the participants scored their tooth sensitivity perception on a visual analogue scale, as well as after 1, 3, and 6 months. Two teeth per group were randomly selected for cone beam computed tomography (CBCT) scanning upon restoration and after 6 months to evaluate the thickness, mineralization density, and area of neoformed dentin. The sensitivity scores among groups were statistically analyzed by the Friedman test (p < 0.05) while dentin neoformation aspects were descriptively compared.</p><p><strong>Results: </strong>All teeth remained vital, and the sensitivity mean scores were not significantly different among groups (p < 0.05). Most of the CBCT sections revealed dentin neoformation in all groups. The mineralization density of affected dentin and the remaining dentin area increased in all groups, albeit higher values were found in IR and R groups.</p><p><strong>Conclusion: </strong>Selective removal of infected dentin followed by mild self-etch adhesive application and composite restoration was effective in maintaining pulp vitality, attenuating postoperative sensitivity, and dentin neoformation after 6 months. PBM therapy improved the mineralization density and area of neoformed dentin.</p><p><strong>Clinical relevance: </strong>Selective caries removal in deep cavities is a regenerative, effective, safe, and simplified treatment that can be combined with photobiomodulation therapy to optimize dentin neoformation.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"192"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662445","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparision of crosslinked hyaluronic acid vs. enamel matrix derivative for periodontal regeneration: an 18-month follow-up randomized clinical trial.","authors":"Manuel Rodríguez-A, Jose María Montiel-Company, Francisco Alpiste-Illueca, Lucía Rodríguez-A, Vanessa Paredes-Gallardo, Andrés López-Roldán","doi":"10.1007/s00784-025-06278-5","DOIUrl":"10.1007/s00784-025-06278-5","url":null,"abstract":"<p><strong>Aim: </strong>To compare the effects of 1.8% hyaluronic acid (HA) and enamel matrix derivative (EMD) on periodontal regeneration in patients with periodontal bone defects, using clinical and radiographic parameters as outcome measures.</p><p><strong>Materials and methods: </strong>We included 53 patients with 53 intrabony defects in this study who were randomly assigned to either the HA (test) or EMD (control) groups. Clinical and radiographic parameters were evaluated at 6, 12, and 18 months after the surgery.</p><p><strong>Results: </strong>Clinical measurements at 6, 12, and 18 months after surgery demonstrated significant improvements in probing depth (PD), clinical attachment level (CAL), recession (REC), and bleeding on probing for both groups compared with baseline (p < 0.001). The EMD group exhibited the highest CAL gain of 2-3 mm at 6 months, observed in 14 of 26 (53.8%) defect sites. Conversely, the HA group demonstrated a CAL gain ≥ 4 mm at 18 months, observed in 13 of 27 (48.1%) defect sites. Radiographic assessments at 6, 12, and 18 months demonstrated significant improvements from baseline for both groups (p < 0.001).</p><p><strong>Conclusion: </strong>We found significant clinical and radiographic benefits of HA and EMD at 18 months, with some limitations in effectiveness for specific intraosseous defects.</p><p><strong>Clinical relevance: </strong>This study demonstrated that hyaluronic acid (HA), combined with minimally invasive techniques, enhances periodontal regeneration by improving PPD reduction, CAL gain, and radiographic bone filling, with cost-effectiveness, application, and bioavailability surpassing that of other biomaterials. Based on these results, HA can be considered a viable alternative to EMD in indicated cases.</p><p><strong>Clinical trial registration number: </strong>clinicalTrial.gov - NCT04274244.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"197"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11922988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and safety of three NiTi systems in endodontic retreatment of MB1 and MB2 root canals: a micro-CT and CBCT combined analysis.","authors":"Airton Oliveira Santos-Junior, Rocharles Cavalcante Fontenele, Karina Ines Medina Carita Tavares, Fernanda Ferrari Esteves Torres, Jáder Camilo Pinto, Pedro Luis Busto Rosim, Andréa Gonçalves, Marco Antonio Hungaro Duarte, Juliane Maria Guerreiro-Tanomaru, Mário Tanomaru-Filho","doi":"10.1007/s00784-025-06273-w","DOIUrl":"https://doi.org/10.1007/s00784-025-06273-w","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the performance in endodontic retreatment and pericervical dentin preservation using ProDesign Logic (PDL), Reciproc Blue (RB), and WaveOne Gold (WOG) NiTi systems in first (MB1) and second (MB2) mesiobuccal root canals of maxillary molars, using cone-beam computed tomography (CBCT) and micro-computed tomography (micro-CT).</p><p><strong>Materials and methods: </strong>MB1 and MB2 canals were prepared, filled, and randomized into four groups (n = 8). MB1 were retreated using PDL up to file 40/0.05 or RB R40 (40/0.06), while MB2 were retreated using PDL up to file 35/0.05 or WOG (35/0.06). Micro-CT scans were performed before and after retreatment to assess the remaining filling material, canal transportation, and canal centralization. Dentin removal and remaining dentin were measured at four levels below the furcation through CBCT scans analyzed with the e-Vol DX software, with micro-CT serving as the reference standard.</p><p><strong>Results: </strong>RB was more effective than PDL in removing MB1 filling material, while PDL outperformed WOG in the apical third of MB2 (p < 0.05). Overall, CBCT measurements for dentin removal were consistent with micro-CT in MB1 but occasionally underestimated in MB2 (p < 0.05). A significant reduction in MB2 danger zone dentin thickness below 0.5 mm was observed after retreatment (p < 0.05).</p><p><strong>Conclusions: </strong>RB was more effective in retreating MB1, while PDL was more efficient in the apical third of MB2. A substantial decrease in dentin thickness in the MB2 danger zone was noted after retreatment, regardless of the NiTi system or imaging modality used. Overall, CBCT scans provided consistent assessments of dentin.</p><p><strong>Clinical relevance: </strong>Selecting appropriate NiTi systems minimizes dentin removal in MB1 and MB2 danger zones, reducing the risk of perforation in the furcation area. CBCT reliably assesses dentin thickness, aiding clinical decisions and improving endodontic retreatment outcomes.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"194"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of intensive application of self-assembling peptide P11-4 with fluoride, casein phosphopeptide amorphous calcium phosphate fluoride and sodium fluoride on streptococcus mutans level in preschool children: a randomized controlled clinical trial.","authors":"Sarah M Khairy, Dalia M Talaat, Sara A M Essa, Karin M L Dowidar","doi":"10.1007/s00784-024-06133-z","DOIUrl":"10.1007/s00784-024-06133-z","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the effect of self-assembling peptide P11-4 with fluoride, casein phosphopeptide amorphous calcium phosphate fluoride (CPP-ACPF) varnish and 5% sodium fluoride varnish (NaF), on Streptococcus mutans (S. mutans) in dental plaque of preschoolers in addition to assessing change in plaque index after their intensive application.</p><p><strong>Methods: </strong>Sixty-six preschoolers were randomly assigned into three groups to receive triple applications of P11-4 with fluoride, CPP-ACPF varnish or NaF. S. mutans count in supragingival plaque samples was assessed at baseline (T0) and after the third application by 48 h (T1), one month (T2) and 3 months (T3). Multivariable linear regression compared the effect of these materials on S. mutans log count at various time intervals. Baseline plaque index was compared to that at T2 and T3.</p><p><strong>Results: </strong>All study groups presented a significant decrease in S. mutans count at T1, T2 and T3. Multivariable linear regression demonstrated a significant more reduction in S. mutans count in CPP-ACPF and NaF groups when compared to P11-4 with fluoride at T1. At T2 and T3, CPP-ACPF showed superior reduction in bacterial count than NaF and P11-4 with fluoride, with no significant difference between the latter two materials. Plaque index was significantly reduced at all study groups at T2 and T3, with CPP-ACPF being the most proficient.</p><p><strong>Conclusion: </strong>CPP-ACPF presented superior antibacterial effect when compared to P11-4 with fluoride or NaF which exhibited comparable antibacterial effect.</p><p><strong>Clinical relevance: </strong>Different remineralizing agents can have additive antibacterial effect against S. mutans that affects individual's future caries experience.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"196"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11923000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correlation of preoperative 18F-FDG-PET/CT tumor staging and maximum standardized uptake values with preoperative CT, postoperative tumor classification, and histopathological parameters of oral squamous cell carcinoma.","authors":"Gunnar Müller, Daniel A Veit, Philipp Becker, Daniel G E Thiem, Peer W Kämmerer, Birte Diekmeyer, Richard Werkmeister, Diana Heimes, Andreas Pabst","doi":"10.1007/s00784-025-06252-1","DOIUrl":"https://doi.org/10.1007/s00784-025-06252-1","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to correlate preoperative 18F-fluorodeoxyglucose-positron emission tomography/computed tomography (18F-FDG-PET/CT) tumor staging, and maximum standardized uptake values (SUV_max) with preoperative CT data, postoperative tumor classification, and histopathological parameters of oral squamous cell carcinoma (OSCC).</p><p><strong>Material and methods: </strong>Thirty-seven OSCC patients staged via full-body 18F-FDG-PET/CT, including contrast agent CT of the head and neck in 2020 and 2021, were enclosed. Patients received tumor resection and stage-dependent neck dissection. Preoperative clinical (c) 18F-FDG-PET/CT UICC tumor stages and TNM classifications were correlated to corresponding CT and to postoperative histopathological (p) UICC tumor stages and TNM classifications. SUV_max of the primary tumor was associated with pUICC and pTNM, including extranodal extension (ENE), perineural invasion (Pn), lymphatic spread (L), vascular invasion (V), tumor grading (G), and -thickness.</p><p><strong>Results: </strong>Comparing 18F-FDG-PET/CT and CT, cUICC, cT, and cN differed in 32.3%, 16.7%, and 37.8% of the cases, respectively. For 18F-FDG-PET/CT, a moderate correlation was found between c- and pUICC (0.494; p = 0.0018) with a misestimation of c- compared to pUICC in 43.2% of the cases. Comparing c- and pTNM, misestimations concerning c- and pT were seen in 51.4% and concerning c- and pN in 37.8% of the cases. An increased SUV_max significantly correlated with increased pT- and pUICC (adjusted Odds ratio 1.103; p = 0.042 and 1.126; p = 0.021, respectively). The predictive quality of an SUV_max cutoff value for detecting cervical lymph node metastases and G was poor, as indicated by the low AUC values from the ROC analysis. No correlations were found between SUV_max and ENE, Pn-, L-, and V-status. A strong correlation was found between SUV_max and tumor thickness with an adjusted coefficient of 1.034 (p = 0.01).</p><p><strong>Conclusion: </strong>The predictive value of 18F-FDG-PET/CT and SUV_max on histopathological tumor classification and parameters appears limited.</p><p><strong>Clinical relevance: </strong>18F-FDG-PET/CT can not unreservedly be recommended for primary OSCC staging. There is an urgent need to specify its indications in detail further.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"189"},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Microvascular free flaps in head and neck reconstruction: an analysis of outcomes in elderly patients.","authors":"Jakob Fenske, Philipp Lampert, Claudius Steffen, Henri Kreiker, Steffen Koerdt, Kilian Kreutzer, Max Heiland, Carsten Rendenbach","doi":"10.1007/s00784-025-06262-z","DOIUrl":"10.1007/s00784-025-06262-z","url":null,"abstract":"<p><strong>Objectives: </strong>Maxillofacial reconstruction using microvascular free flaps is a well-established procedure to restore facial defects across various patients. Elderly patients face increased perioperative risks due to higher prevalence of comorbidities. This study aims to evaluate the characteristics of patients aged ≥ 75 years and assess the impact of advanced age on outcomes in microvascular free flap reconstruction for head and neck defects.</p><p><strong>Methods: </strong>A retrospective analysis was conducted on patients who underwent microvascular free flap head and neck reconstruction between April 2017 and July 2023. After matching, patients aged ≥ 75 were compared to those < 75 years regarding comorbidities, surgical and treatment variables, complication rates and outcomes. Multivariate models were developed to test the influence of age on flap complications.</p><p><strong>Results: </strong>1050 patients met the inclusion criteria. 290 patients (28%) were ≥ 75 years old. Following case matching, 580 patients (276 females, mean age 74.1 ± 8.9 years) were included in the analysis. Patients ≥ 75 years had higher rates of comorbidities, co-medications and postoperative delirium. No significant differences were observed in flap complications between both groups in univariate analysis. Although one multivariate model suggested a potential non-linear effect of age on flap complications, this was not validated in another model.</p><p><strong>Conclusions: </strong>Despite the increased prevalence of comorbidities and perioperative risk factors, microvascular free flap reconstruction remains a safe and viable procedure for elderly patients when performed in a structured setting at a high-volume center, as complication rates do not appear to be directly influenced by age.</p><p><strong>Clinical relevance: </strong>Free Flap surgery is a safe procedure in elderly patients.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"190"},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919923/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in creeping attachment for soft tissue augmentation surgery.","authors":"Binyan Luo, Jianping Xiao, Fuhua Yan, Yanfen Li, Baochun Tan","doi":"10.1007/s00784-025-06270-z","DOIUrl":"https://doi.org/10.1007/s00784-025-06270-z","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate creeping attachment after soft tissue augmentation surgery in areas with gingival recession.</p><p><strong>Materials and methods: </strong>This study observed sites of gingival recession who underwent soft tissue augmentation surgery. Changes in gingival recession depth (RD), keratinized tissue height (KTH) and gingival thickness (GT) were measured at 1, 3, 6, and 12 months post-surgery. The changes in creeping attachment (CA) and mean root coverage (MRC) were calculated, and the relationship between the increase in GT and CA was analyzed.</p><p><strong>Results: </strong>A total of 58 sites in 24 patients were observed. At 1 month postoperatively, RD, KTH and GT improved in all patients with CA of 0.66 ± 0.40 mm and MRC of 22.9 ± 13.9%. All indicators further improved from 3 to 12 months post-surgery. There was a positive correlation between the increase in GT and CA from 1 to 6 months post-surgery.</p><p><strong>Conclusion: </strong>Significant changes in RD, KTH and GT were observed 1 month after soft tissue augmentation surgery, with all indicators stabilizing by 3 months. The increase of GT was positively correlated with CA, and the phenomenon of creeping attachment was still observed 1 year after the surgery.</p><p><strong>Clinical relevance: </strong>The study identified changes in creeping attachment after soft tissue augmentation surgery to help clinicians understand this phenomenon better.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"191"},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656297","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}