Clinical Oral Investigations最新文献

{"title":"Proliferative verrucous leukoplakia is associated with aggressive periodontal pathogens: a comparative study with oral lichen planus and chronic periodontitis cases.","authors":"Jan Liska, Veronika Liskova, Nikoleta Molnarova, Ondrej Topolcan, Petr Posta, Lukas Hauer","doi":"10.1007/s00784-025-06525-9","DOIUrl":"10.1007/s00784-025-06525-9","url":null,"abstract":"","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"470"},"PeriodicalIF":3.1,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457579/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145124653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The genetic basis of tooth impaction: a systematic review.","authors":"S Papadopoulos, I Ziakas, E Panteris, A Chatzigianni","doi":"10.1007/s00784-025-06520-0","DOIUrl":"10.1007/s00784-025-06520-0","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this review was to identify genes and genetic traits that cause tooth impaction by systematically collecting the best available evidence.</p><p><strong>Materials and methods: </strong>Relevant literature was searched on 10 databases up to March 2025 and search criteria were formulated using the PECOS and PRISMA guidelines. The eligibility criteria included case-control, cohort and cross-sectional observational studies, which examined human subjects regardless of age or sex and focused on the analysis of genes, alleles, gene variants, non-coding RNAs, or other genetic factors that cause tooth impaction. The risk of bias of eligible studies was evaluated using the Joanna Briggs Institute (JBI) Critical Appraisal Checklists.</p><p><strong>Results: </strong>Overall, 15 studies met the inclusion criteria. Several important genes were highlighted and mutations and polymorphism in these genes showed an increase in the risk of tooth impaction. Specifically, MSX1 rs12532, PAX9 rs4904210 and rs2073247, AXIN2 rs2240308, as well as MSX2 rs4868444 and ARNT2 rs140220410 revealed significant association with canine, third molar or general tooth impaction. Synergistic effects of some gene genotypes were also addressed. The third molar impaction was associated with specific long non-coding RNAs of the corresponding dental follicles, and with the individual's blood group. According to the JBI checklist, the studies showed high methodological quality.</p><p><strong>Conclusion: </strong>Three key genes, namely MSX1, PAX9 and AXIN2, appear to have an important role in tooth impaction. Moreover, limited evidence suggests that long non-coding RNAs and the type of individual's blood group could be potential biomarkers of tooth impaction. However, the contradictory results from the included studies reduce the certainty of any solid conclusions. Additional studies with large samples involving advanced methodologies for genetic testing are essential to pinpoint the underlying genetic factors of tooth impaction.</p><p><strong>Clinical relevance: </strong>Understanding the genetic factors and specific mutations behind tooth impaction, may enhance early diagnosis, prevention of impaction and treatment.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"469"},"PeriodicalIF":3.1,"publicationDate":"2025-09-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12454535/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145112168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of dry mouth on the pressure/pain sensitivity of the oral mucosa of patients using mandibular implant-supported overdenture prosthesis.","authors":"Ravza Eraslan, Duygu Kılıç, Simanur Bayyıldız, Deniz Danış Yılmaz, Hilal Sert","doi":"10.1007/s00784-025-06523-x","DOIUrl":"https://doi.org/10.1007/s00784-025-06523-x","url":null,"abstract":"","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"468"},"PeriodicalIF":3.1,"publicationDate":"2025-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145091312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resin infiltration and in-office dental bleaching on different substrates: hydrogen peroxide penetration, color change, and enamel morphology- an in vitro study.","authors":"Taynara S Carneiro, Bruno Baracco, Michel Wendlinger, Michael Willian Favoreto, Gabriel Cochinski, Gabrielle Centenaro, Laura Ceballos, Alessandro D Loguercio","doi":"10.1007/s00784-025-06569-x","DOIUrl":"https://doi.org/10.1007/s00784-025-06569-x","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the penetration of hydrogen peroxide into the pulp chamber, color change, and enamel morphology of human teeth with different substrates (sound and white spot), subjected to the application of a resin infiltration (RI) and in-office bleaching at different time intervals (immediately and 7 days after RI application).</p><p><strong>Materials and methods: </strong>Fifty-four sound human premolars were randomly distributed into six groups (n = 9), all subdivided according to substrate (sound and white spot): bleaching with 35% hydrogen peroxide only (HP); RI followed by immediate bleaching (RI/HPi); and RI followed by bleaching after 7 days (RI/HP7d). The concentration of hydrogen peroxide (µg/mL) was measured by UV-Vis spectrophotometry, color change was evaluated using a digital spectrophotometer (ΔE₀₀ and WI_D), and enamel surface morphology was analyzed by scanning electron microscopy (SEM) (α = 0.05).</p><p><strong>Results: </strong>In the groups without RI (HP), teeth with white spot lesions showed approximately 40% greater hydrogen peroxide penetration than sound teeth (p = 0.15). RI significantly reduced this penetration, regardless of the substrate or bleaching time (p > 0.02). According to WI_D values, the groups treated with RI (RI/HPi and RI/HP7d) achieved a final color similar to that of sound enamel treated with 35% HP. Enamel morphology was more homogeneous in the groups that received resin infiltration.</p><p><strong>Conclusions: </strong>The application of RI prior to in-office bleaching significantly reduced hydrogen peroxide penetration into the pulp chamber without compromising bleaching efficacy. In teeth with white spot lesions, it led to a final shade comparable to that of sound teeth and resulted in a more uniform enamel morphology.</p><p><strong>Clinical relevance: </strong>Resin infiltration is an effective, minimally invasive approach for treating white spot lesions, improving bleaching outcomes and limiting hydrogen peroxide penetration.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"465"},"PeriodicalIF":3.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Using injectable Platelet-Rich fibrin to improve recovery after impacted lower third molar extraction: a randomized controlled clinical trial.","authors":"Angelo Aliberti, Mauro Mariniello, Marco Bergaminelli, Pasquale Dolce, Dario Gargiulo, Gilberto Sammartino, Gianrico Spagnuolo, Roberta Gasparro","doi":"10.1007/s00784-025-06563-3","DOIUrl":"10.1007/s00784-025-06563-3","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this RCT was to clinically evaluate swelling, pain and wound healing following submucosal infiltration of injectable Platelet-Rich Fibrin (i-PRF) after extraction of impacted lower third molar.</p><p><strong>Materials and methods: </strong>The study was designed as a double-blinded, parallel group, randomized controlled clinical trial. 56 patients were divided into 2 groups: in the control group the socket was left to heal spontaneously, while the test group was treated with submucosal infiltration of i-PRF. Swelling was measured with a flexible ruler using the diagonals joining Trago and Pogonion, Gonion and labial cleft. The swelling was calculated as the sum of these diagonals before surgery, on day 3 and 7. Pain was assessed by VAS scale until the 7th postoperative day. Surgical wound healing was evaluated by the Healing Index by Landry on 3, 7 ,14 and 21st day postosperatively. The relation between duration of intervention and total swelling was also evaluated.</p><p><strong>Results: </strong>56 patients were enrolled in this study (28 for the test group and 28 for the control group). Randomization resulted in groups with similar baseline characteristics. No patients were lost during the follow-up and no adverse events were noted. On day 3 the total swelling was 12.7 ± 0.92 mm for control group and 12.1 ± 0.75 mm for test group; on day 7 it was 12.3 ± 0.88 mm for control group and 11.7 ± 0.73 mm for test group. A statistically significant difference was found on day 3 (p = 0.006) and on day 7 (p = 0.018). The relation between total swelling and duration of intervention was not statistically significant (p = 0.276). A significant reduction in pain scores was observed in the i-PRF group on days 1 and 3 (p < 0.001). Surgical wound healing also showed statistically significant improvement in the i-PRF group at all time points (days 3, 7, 14, and 21; p < 0.05).</p><p><strong>Conclusions: </strong>Within the limit of our study, this randomized controlled clinical trial suggests that submucosal infiltration of i-PRF after the extraction of impacted lower third molars effectively reduces postoperative swelling and pain, while also promoting faster wound healing.</p><p><strong>Clinical relevance: </strong>The adjunctive use of injectable platelet-rich fibrin (i‑PRF) after surgical removal of impacted mandibular third molars may contribute to improve early postoperative outcomes by attenuating soft tissue inflammation, reducing pain intensity, and accelerating wound healing. By potentially lowering the need for nonsteroidal anti-inflammatory drugs (NSAIDs) and minimizing associated adverse effects, i‑PRF represents a minimally invasive, autologous approach that could enhance patient comfort, reduce recovery time, and support faster return to daily activities.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"467"},"PeriodicalIF":3.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449355/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145085025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endodontic treatment and management of patients under antiresorptive treatment: a scoping review on MRONJ risk.","authors":"Giulio Zavalloni, Andrea Spinelli, Martina Coppini, Rodolfo Mauceri, Giuseppina Campisi, Jacopo Lenzi, Maria Giovanna Gandolfi, Carlo Prati, Fausto Zamparini","doi":"10.1007/s00784-025-06543-7","DOIUrl":"10.1007/s00784-025-06543-7","url":null,"abstract":"<p><strong>Objectives: </strong>To summarize the current scientific evidence on the implications of root canal treatment (RCT) in patients receiving antiresorptive therapy and to outline best practices for managing such cases to prevent MRONJ.</p><p><strong>Materials and methods: </strong>A search strategy across PubMed, Web of Science and Scopus was performed. Clinical studies and reports on RCTs in patients on antiresorptive therapy were screened by two independent reviewers. Data on patient factors (sex, age, disease, treatment, outcome) and tooth-related aspects (procedure, diagnosis, anesthesia, irrigation, obturation, antibiotics) were extracted.</p><p><strong>Results: </strong>Of the 514 studies identified, 15 articles (133 patients) met inclusion criteria. One prospective study included 65 patients and 96 RCTs; the remaining patients were reported in case reports or series and in two retrospective studies. Endodontic protocols varied largely across studies. The most common indications for RCT were pulpitis (n = 62) and periapical lesions with acute endodontic diseases (n = 119). All patients were undergoing antiresorptive therapy with oral or intravenous bisphosphonates for the management of osteoporosis or oncologic conditions. RCT was performed in all cases using conventional protocols that included local anesthesia (in some cases without vasoconstrictors), mechanical instrumentation, chemical irrigation (most commonly with sodium hypochlorite) and root canal obturation. Five studies reported antibiotic use. The cases of MRONJ (n = 7, 5.3%; mean treatment duration was 49 months) appeared only in oncological patients.</p><p><strong>Conclusions: </strong>RCT appears to be a safe procedure for patients receiving bisphosphonates. Cases in which RCT appeared to act as a trigger for MRONJ are rare and ambiguous and seem primarily associated with procedural errors or high-risk patients. Although some recommendations for endodontic practice to prevent MRONJ have been proposed, there is a clear need for further research in this area.</p><p><strong>Clinical relevance: </strong>Dentists can safely perform RCT in patients undergoing bisphosphonate therapy. Some clinical recommendations based on the available literature are provided.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"466"},"PeriodicalIF":3.1,"publicationDate":"2025-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12449421/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145084973","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prognosis of multi-unit implant supported and combined tooth-implant supported fixed dental prostheses: a retrospective cohort study with a mean observation period of 4.27 years.","authors":"Moritz Waldecker, Peter Rammelsberg","doi":"10.1007/s00784-025-06548-2","DOIUrl":"10.1007/s00784-025-06548-2","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this retrospective cohort study was to evaluate survival of multi-unit FDPs in comparison to 3-unit fixed dental prostheses (FDPs).</p><p><strong>Materials and methods: </strong>434 FDPs placed in 326 patients were selected from a prospective clinical long-term study. 213 FDPs were solely implant-supported, 154 FDPs tooth-implant supported, and 67 FDPs were cantilever FDPs. The most FDPs had 3-units (n = 315), 95 FDPs had 4-units, and 24 FDPs had more than 4 units. The most FDPs had a unit/abutment relation of ≤ 1.5 (n = 336), and 98 FDPs had a relation of > 1.5. Kaplan-Meier curves were used to estimate the survival probability of the FDPs for the variables type of FDP support, number of units and loading factor. Univariate log-rank tests were used to test for differences between groups within variables.</p><p><strong>Results: </strong>The mean observation period was 4.27 years. In the observation period of up to 12.6 years 17 FDPs failed mainly through technical complications. The underlying causes were implant loss (n = 6), abutment tooth loss (n = 5), loosening of the abutment screw (n = 1), and extensive chipping (n = 5). Survival probability of all FDPs was ≥ 89,6% after 10 years. Log-rank tests revealed no significant differences between groups for all variables (support, number of units, and loading factor (p ≥ .339).</p><p><strong>Conclusions: </strong>Because of their promising prognosis 4-unit FDPs placed on implants or a combination of tooth and implant can be recommended as an alternative to 3-unit FDPs. A higher number of implants in relation to FDP units does not improve the prognosis of FDPs.</p><p><strong>Clinical relevance: </strong>Support, number of units and the loading factor do not influence the survival of FDPs. Therefore, 4-unit FDPs placed on implants or a combination of tooth and implant are a valuable treatment alternative to 3-unit FDPs.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"463"},"PeriodicalIF":3.1,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12443873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074566","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning in sex estimation using CBCT morphometric measurements of canines.","authors":"Alice Corrêa Silva-Sousa, Gustavo Dos Santos Cardoso, Antônio Castelo Branco, Erika Calvano Küchler, Flares Baratto-Filho, Amanda Pelegrin Candemil, Manoel Damião Sousa-Neto, Cristiano Miranda de Araujo","doi":"10.1007/s00784-025-06559-z","DOIUrl":"https://doi.org/10.1007/s00784-025-06559-z","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to assess measurements of the maxillary canines using Cone Beam Computed Tomography (CBCT) and develop a machine learning model for sex estimation.</p><p><strong>Materials and methods: </strong>CBCT scans from 610 patients were screened. The maxillary canines were examined to measure total tooth length, average enamel thickness, and mesiodistal width. Various supervised machine learning algorithms were employed to construct predictive models, including Decision Tree, Gradient Boosting Classifier, K-Nearest Neighbors (KNN), Logistic Regression, Multi-Layer Perceptron (MLP), Random Forest Classifier, Support Vector Machine (SVM), XGBoost, LightGBM, and CatBoost. Validation of each model was performed using a 10-fold cross-validation approach. Metrics such as area under the curve (AUC), accuracy, recall, precision, and F1 Score were computed, with ROC curves generated for visualization.</p><p><strong>Results: </strong>The total length of the tooth proved to be the variable with the highest predictive power. The algorithms that demonstrated superior performance in terms of AUC were LightGBM and Logistic Regression, achieving AUC values of 0.77 [CI95% = 0.65-0.89] and 0.75 [CI95% = 0.62-0.86] for the test data, and 0.74 [CI95% = 0.70-0.80] and 0.75 [CI95% = 0.70-0.79] in cross-validation, respectively. Both models also showed high precision values.</p><p><strong>Conclusions: </strong>The use of maxillary canine measurements, combined with supervised machine learning techniques, has proven to be viable for sex estimation.</p><p><strong>Clinical relevance: </strong>The machine learning approach combined with is a low-cost option as it relies solely on a single anatomical structure.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"461"},"PeriodicalIF":3.1,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Numerical simulation and functional evaluation of upper airway before and after twin block treatment with different respiratory pathways.","authors":"Shuai Chen, Yu Han, Jingying Wang, Xue Song","doi":"10.1007/s00784-025-06533-9","DOIUrl":"https://doi.org/10.1007/s00784-025-06533-9","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of this study was to evaluate the changes of upper airway ventilation function in children with mandible retrognathia under different respiratory pathways after Twin Block (TB) using computational fluid dynamics (CFD).</p><p><strong>Materials and methods: </strong>This study included 20 patients with mandible retrognathia who underwent TB treatment, including 8 males and 12 females (age 10.67 ± 1.51 years). The airflow information obtained by using an oral and nasal thermistor was used as the boundary condition for CFD simulation to analyze the influence of different respiratory paths on upper airway flow.</p><p><strong>Results: </strong>After TB, the pressure drop, resistance, and shear force in the velopharynx (Vp) and glossopharynx (Gp) were significantly reduced during nasal breathing. Pearson correlation test showed that obstructive apnea index (OAI) was negatively correlated with the internal pressure of the upper airway, and positively correlated with the pressure drop, resistance, and maximum shear force of the upper airway, especially the velopharynx resistance, which showed a significant positive correlation. For patients with obvious oral breathing, the improvement of fluid dynamics parameters inside the glossopharyngeal region was more significant. The OAI was significantly positively correlated with the pressure drop and resistance in the glossopharynx region.</p><p><strong>Conclusions: </strong>For different respiratory pathways, TB can improve the ventilation function of patients with mandible retrognathia.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"459"},"PeriodicalIF":3.1,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioactive glass products for the treatment of dentin hypersensitivity: a scoping review.","authors":"João Vitor do Nascimento Santos, Pablo Winícius Sousa de Moraes, Matheus Nobrega Pereira, Juan Vitor Costa Leite, Gabriela de Alencar Pinto Magalhães, Kim Capehart, Ana Karina Maciel de Andrade, Renally Bezerra Wanderley E Lima","doi":"10.1007/s00784-025-06516-w","DOIUrl":"10.1007/s00784-025-06516-w","url":null,"abstract":"<p><strong>Objective: </strong>To systematically map and synthesize the current scientific evidence on the active ingredients and effectiveness of bioactive glass-containing products for the treatment of dentin hypersensitivity, and to identify knowledge gaps.</p><p><strong>Materials and methods: </strong>This scoping review followed PRISMA-ScR guidelines and was registered on the Open Science Framework platform. Searches were conducted in PubMed/MEDLINE, Embase, Scopus, and Web of Science up to March 2025. Studies of any evidence level investigating bioactive glasses, bioactive glass-ceramics, or related products for dentin hypersensitivity treatment, evaluating parameters like dentinal tubule occlusion, dental remineralization, or pain relief, were included. Descriptive analysis was applied to all included studies.</p><p><strong>Results: </strong>A total of 72 studies were reviewed, primarily in vitro (n = 46), with randomized clinical trials (n = 17) and reviews (n = 9) also represented. Calcium sodium phosphosilicate was the most analyzed bioactive glass (n = 33), often compared with arginine, nano-hydroxyapatite, potassium nitrate, and strontium acetate formulations. Products were commonly presented as toothpaste (n = 39), powder (n = 14), and gel (n = 6). In vitro studies frequently reported benefits in dentinal tubule occlusion, predominantly assessed by scanning electron microscopy. Clinical studies demonstrated reductions in dentin hypersensitivity-related pain, commonly assessed using air jet or cold-water stimuli combined with Visual Analog Scale (VAS) scores or the Schiff Cold Air Sensitivity Scale (SCSS), with follow-up periods ranging from 1 to 11 weeks.</p><p><strong>Conclusion: </strong>Toothpaste containing calcium sodium phosphosilicate was the most extensively studied bioactive glass-based product for dentin hypersensitivity treatment, with in vitro evidence supporting its effectiveness. Additional clinical research is needed to confirm these findings.</p><p><strong>Clinical significance: </strong>Bioactive glass products show promise in the treatment of dentin hypersensitivity. Given the variability in composition, evidence-based selection is key to ensuring effective treatment and improving patient outcomes.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"464"},"PeriodicalIF":3.1,"publicationDate":"2025-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145074533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}