Clinical Oral Investigations最新文献

{"title":"Automatic mandibular third molar and mandibular canal relationship determination based on deep learning models for preoperative risk reduction.","authors":"Elham Tahsin Yasin, Mediha Erturk, Melek Tassoker, Murat Koklu","doi":"10.1007/s00784-025-06285-6","DOIUrl":"10.1007/s00784-025-06285-6","url":null,"abstract":"<p><strong>Objectives: </strong>This study explores the application of deep learning models for classifying the spatial relationship between mandibular third molars and the mandibular canal using cone-beam computed tomography images. Accurate classification of this relationship is essential for preoperative planning, as improper assessment can lead to complications such as inferior alveolar nerve injury during extractions.</p><p><strong>Materials and methods: </strong>A dataset of 305 cone-beam computed tomography scans, categorized into three classes (not contacted, nearly contacted, and contacted), was meticulously annotated and validated by maxillofacial radiology experts to ensure reliability. Multiple state-of-the-art convolutional neural networks, including MobileNet, Xception, and DenseNet201, were trained and evaluated. Performance metrics were analysed.</p><p><strong>Results: </strong>MobileNet achieved the highest overall performance, with an accuracy of 99.44%. Xception and DenseNet201 also demonstrated strong classification capabilities, with accuracies of 98.74% and 98.73%, respectively.</p><p><strong>Conclusions: </strong>These results highlight the potential of deep learning models to automate and improve the accuracy and consistency of mandibular third molars and the mandibular canal relationship classifications.</p><p><strong>Clinical relevance: </strong>The integration of such systems into clinical workflows could enhance surgical risk assessments, streamline diagnostics, and reduce reliance on manual analysis, particularly in resource-constrained settings. This study contributes to advancing the use of artificial intelligence in dental imaging, offering a promising avenue for safer and more efficient surgical planning.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"203"},"PeriodicalIF":3.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11933192/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Varying responses to periodontal treatment in different extent of plaque-induced gingivitis: a prospective cohort study.","authors":"Xuan Ying, Yue Dai, Guannan Bai, Zijian Cheng, Xia Cai","doi":"10.1007/s00784-025-06282-9","DOIUrl":"https://doi.org/10.1007/s00784-025-06282-9","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the clinical response to periodontal treatment in localized and generalized gingivitis using periodontal variables and patient-reported outcomes (PROs).</p><p><strong>Materials and methods: </strong>Sixty participants (30 with localized gingivitis, 30 with generalized gingivitis) underwent scaling, polishing, and oral hygiene instruction at baseline and monthly follow-ups until periodontal health was restored. Periodontal variables (bleeding on probing [BOP], gingival index [GI], and plaque index [PLI]) along with PROs on oral hygiene practices and the Self-Efficacy Scale for Self-Care (SESS) were assessed.</p><p><strong>Results: </strong>At 1-month follow-up, generalized gingivitis showed significantly greater improvements in BOP (p < 0.001) and GI (p < 0.001) versus localized gingivitis, with no intergroup difference in PLI reduction (p = 0.747). Periodontal health was achieved in 80% of localized cases versus 30% of generalized cases after single-session therapy (p < 0.001), with 70% of generalized cases requiring multiple re-treatments. Unresolved generalized cases had higher baseline BOP (p = 0.014) but similar baseline PLI (p = 0.322) and no significant differences in treatment-induced BOP (p = 0.137) or PLI changes (p = 0.563). SESS scores improved significantly in both groups, with greater SE-D score improvement in localized cases. Localized gingivitis had higher baseline prolonged brushing rates (> 2 min: 66.7% vs. 33.3%), but post-intervention oral hygiene did not differ between groups.</p><p><strong>Conclusions: </strong>Localized gingivitis responded well to single-session therapy, whereas generalized gingivitis required multiple treatments due to higher baseline inflammation, emphasizing the need for distinct clinical strategies.</p><p><strong>Clinical relevance: </strong>This study supports subtype-specific management in gingivitis, advocating single-session therapy for localized cases and staged interventions for generalized cases to optimize outcomes and reduce overtreatment.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"204"},"PeriodicalIF":3.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of a local application of 10% doxycycline gel in the prevention of medication-related osteonecrosis of the jaw in rats.","authors":"Henrique Hadad, Laís Kawamata de Jesus, Maísa Pereira-Silva, Maria Eduarda de Freitas Santana Oliveira, Naara Gabriela Monteiro, Pier Paolo Poli, Carlo Maiorana, Roberta Okamoto, Fernando Pozzi Semeghini Guastaldi, Juliano Milanezi de Almeida, Francisley Ávila Souza","doi":"10.1007/s00784-025-06279-4","DOIUrl":"https://doi.org/10.1007/s00784-025-06279-4","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate doxycycline on the prevention of MRONJ.</p><p><strong>Materials and methods: </strong>Seventy-two Wistar rats were sorted into 3 groups and subjected to tooth extractions. The first group received systemic saline solution (SAL), the second received zoledronic acid (ZA), and the third, besides the systemic ZA, the post-extraction socket received local application of doxycycline (DOXI) gel. Samples were collected and analyzed at 7, 14, and 28 postoperative days.</p><p><strong>Results: </strong>DOXI group presented higher percentage of vital bone area as compared with ZA at 7 (p = 0.0058), 14 (p < 0.0001), and 28 days (p < 0.0001). TRAP immunolabeling was lower in ZA and DOXI at 7 and 14 days, while OCN immunolabeling was similar between the ZA and DOXI, except at 7 days. At 14 and 28 days, DOXI group presented more collagen type 3 and 1 (p < 0.0001) as compared with ZA. RUNX2, ALP, OCN, and RANKL gene expression was downregulated in ZA at 7 days. Conversely, DOXI upregulated these markers and OPG over time (p < 0.05).</p><p><strong>Conclusion: </strong>Doxycycline is an effective local agent for preventing MRONJ, favoring alveolar bone healing.</p><p><strong>Clinical relevance: </strong>Although widely studied, MRONJ remains a significant challenge in dentistry. The search for preventive methods is important to assure safety for in patients under antiresorptive therapy that demand surgical dental treatment. Doxycycline is well-established in dentistry, and the proposal of using this medication as a gel makes it more appealing since it is applied locally and has negligible adverse effects.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"205"},"PeriodicalIF":3.1,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Orthodontic appliances and their diagnostic impact to brain MRI.","authors":"Lisa Latzko, Anna Schmit, Bernhard Glodny, Astrid E Grams, Christoph Birkl, Adriano G Crismani","doi":"10.1007/s00784-025-06275-8","DOIUrl":"10.1007/s00784-025-06275-8","url":null,"abstract":"<p><strong>Objective: </strong>The aim of this study was to display and quantify signal loss artifacts in 1.5T and 3T brain MRI on a volunteer with different orthodontic appliances.</p><p><strong>Materials and methods: </strong>In this experimental study, three different orthodontic appliances were examined on a 1.5T and a 3T MRI scanner in a healthy adult with normal dental occlusion: stainless-steel brackets paired with a nickel-titanium archwire; brackets, archwire, and stainless-steel molar bands; brackets, archwire, molar bands, and a stainless-steel trans-palatal archwire. Assessment of diverse anatomical structures, including different cerebral structures and blood vessels, was conducted using a six-point Likert scale.</p><p><strong>Results: </strong>Utilizing conventional stainless-steel brackets and a nickel-titanium archwire, with or without the inclusion of stainless-steel molar bands, all cerebral structures demonstrated satisfactory assessability with high diagnostic quality under both 1.5T and 3T MRI. For example, with an average rating of 85/85 for T2 and 77/85 for susceptibility-weighted imaging (SWI). Upon introduction of the stainless-steel trans-palatal archwire, additional artifacts were observed, predominantly manifesting in SWI (20/85), diffusion-weighted imaging (DWI) sequences (31/85), and phase contrast angiography (PCA) (17/20). Differences in artifact severity were mainly observed in the SWI and DWI sequences.</p><p><strong>Conclusion: </strong>Based on the findings of this study, it is not imperative to entirely remove orthodontic appliances to achieve sufficient diagnostic quality in brain MRI. In instances where SWI or DWI sequences are necessitated, the removal of solely the trans-palatal stainless-steel archwire should be contemplated, given its straightforward execution.</p><p><strong>Clinical relevance: </strong>These results highlight the potential to reduce injury risk during orthodontic appliance removal, expedite imaging procedures, and consequently accelerate diagnostic processes, particularly crucial in emergencies.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"202"},"PeriodicalIF":3.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of collagenated bone substitutes for bone regeneration in two-wall-damaged extraction sockets without barrier membranes.","authors":"Seungho Jeong, Franz J Strauss, Hae Jee Shin, Jin-Young Park, Jae-Kook Cha, Jung-Seok Lee","doi":"10.1007/s00784-025-06281-w","DOIUrl":"https://doi.org/10.1007/s00784-025-06281-w","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate ridge dimensional changes following alveolar ridge augmentation in two-wall-damaged extraction sockets without a barrier membrane, using two types of collagenated bone substitutes i. cross-linked (CL-CB) and ii. non-cross-linked (NCL-CB).</p><p><strong>Materials and methods: </strong>Two-wall defects were created in mandibles of seven beagle dogs and treated in three groups: (i) no grafting (control), (ii) sockets filled with NCL-CB, and (iii) sockets filled with CL-CB. No barrier membrane was used. One animal was sacrificed after 1 week of healing for tissue assessments (n = 1), and the other six were sacrificed after 8 weeks of healing for microcomputed tomography (micro-CT) and histological analyses (n = 6).</p><p><strong>Results: </strong>Compared to unextracted sites, radiographic analysis revealed that the alveolar ridge dimension decreased to 83.29 ± 24.96% in group NCL-CB, 73.46 ± 16.59% in group CL-CB and 55.41 ± 12.95% in non-grafted sites (intergroup p = 0.062). Histological analysis showed that compared to baseline values the ridge area decreased to 68.75 ± 14.20% in the non-grafted group, 79.88 ± 20.05% in the NCL-CB group and 76.10 ± 21.09% in the CL-CB group with no significant differences between the groups (p > 0.05). Qualitative histological analyses revealed significantly less mineralized tissue in both test groups, amounting to 25.28 ± 10.40% in group NCL-CB, 29.86 ± 12.04% in group CL-CB, and 67.15 ± 14.35% in non-grafted sites (intergroup p < 0.05).</p><p><strong>Conclusion: </strong>The efficacy of alveolar ridge augmentation using either cross-linked or non-cross-linked collagenated bone substitutes alone might be limited in severely damaged sockets such as those with two-wall defects.</p><p><strong>Clinical relevance: </strong>In situations where sockets are extensively damaged, like those with two-wall defects, relying solely on soft-type bone block substitutes without a barrier membrane may not provide sufficient bone regeneration. This study highlights the importance of considering additional regenerative strategies, such as the use of barrier membranes, to enhance clinical outcomes.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"201"},"PeriodicalIF":3.1,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of long-term bond strength and mechanical properties of a recently launched light-cure resin cement for veneer cementation.","authors":"Hong Zhang, Yuan Yuan, Yu Toida, Papichaya Intajak, Hidehiko Sano, Atsushi Tomokiyo","doi":"10.1007/s00784-025-06269-6","DOIUrl":"https://doi.org/10.1007/s00784-025-06269-6","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to evaluate the initial and six-month bonding performance and mechanical properties of a recently launched light-cure resin cement compared to light-cure, dual-cure resin cements, and resin composite used for veneer cementation.</p><p><strong>Materials and methods: </strong>Four luting cements-Panavia Veneer LC (PVL), Variolink Esthetic LC (VEL), Panavia V5 (PV5), and Clearfil AP-X (APX)-were tested for microtensile bond strength (μTBS), Knoop hardness (KHN), degree of conversion (DC), and ultimate tensile strength (UTS) at 24-hour and 6-month. All values were subjected to statistical analysis (α = 0.05). Fracture mode and resin-dentin interfaces were observed via SEM.</p><p><strong>Results: </strong>One-way ANOVA revealed significant differences among the materials for each measured property at 24-hour and 6-month (p < 0.001). The PVL group demonstrated superior bond strength at both time points (24-hour: 58.72 MPa; 6-month: 59.13 MPa), comparable to APX. In contrast, the VEL group showed a significant decrease in μTBS from 24-hour (27.62 MPa) to 6-month (10.65 MPa) (p < 0.001). The dual-cure cement PV5 showed marked improvements in μTBS and mechanical properties beyond 24 h (p < 0.001). KHN and UTS were highest in APX. PVL and APX had higher DC values than VEL and PV5. SEM revealed variations in resin-dentin interfaces across the groups.</p><p><strong>Conclusions: </strong>PVL demonstrated reliable and durable bonding performance, while PV5 showed improvements after 24 h, suggesting the need for extended curing time for optimal performance.</p><p><strong>Clinical relevance: </strong>PVL provides durable bonding and mechanical performance, making it a promising option for veneer cementation in clinical practice.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"199"},"PeriodicalIF":3.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effects of β-TCP and/or xenogeneic bone substitute on alveolar ridge preservation: a randomized clinical trial.","authors":"Liu Gao, Huilin Zhu, Yuqian Kou, Hongcheng Hu, Yuwei Wu, Zhihui Tang, Qing Li","doi":"10.1007/s00784-025-06272-x","DOIUrl":"https://doi.org/10.1007/s00784-025-06272-x","url":null,"abstract":"<p><strong>Objectives: </strong>After tooth extraction, the alveolar ridge undergoes significant absorption, and the alveolar ridge preservation (ARP) will alleviate the complexity of implantation operations in specific clinical occasions and then improve the functionality and aesthetics of subsequent restoration. However, the effectiveness of β-tricalcium phosphate (β-TCP) composite materials for ARP needs to be confirmed by more clinical trials and more sufficient evidence. This study was aimed at evaluating the effects of β-TCP coating porous bovine deproteinization bone (β-TCP/PBDB) on ARP when compared with Bio-Oss^®.</p><p><strong>Materials and methods: </strong>After baseline clinical examination, teeth extractions and the ARP were conducted randomly by β-TCP/PBDB or the Bio-Oss^®. A collagen sponge was applied over the bone substitutes. After 6 months, clinical examination and cone-beam computerized tomography (CBCT) imaging analysis were conducted to evaluate the changes in alveolar bone volume.</p><p><strong>Results: </strong>In the clinical trial, a total of 123 patients successfully completed the protocol. The surgical socket and the soft tissues healed well. The reduction of alveolar ridge width was 1.27 ± 1.32 mm, 0.89 ± 1.31 mm, and 0.63 ± 1.37 mm at three levels (1 mm, 3 mm, 5 mm) below the crest of alveolar ridge respectively using β-TCP/PBDB, while those were 1.12 ± 1.65 mm, 0.55 ± 1.41 mm, 0.56 ± 1.32 mm respectively in the Bio-Oss^® group. The reduction of alveolar ridge height was 0.75 ± 1.96 mm in buccal and 0.95 ± 1.96 mm in lingual using β-TCP/PBDB while those were 1.01 ± 2.44 mm and 0.99 ± 2.13 mm respectively in the Bio-Oss^® group. There is no significant difference in the width and height changes of the alveolar ridge compared to Bio-Oss^® (p > 0.05).</p><p><strong>Conclusions: </strong>This prospective, randomized, controlled clinical trial provided evidence that β-TCP/PBDB is a safe material and the effectiveness of β-TCP/PBDB in maintaining the volume and contour of the alveolar ridge is comparable to that of the Bio-Oss^® material.</p><p><strong>Clinical relevance: </strong>The β-TCP/PBDB can be used as one option of bone substitute material for ARP.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"200"},"PeriodicalIF":3.1,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143673303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction to: Genetic risk factors for periodontitis: a genome-wide association study using UK Biobank data.","authors":"Chenyi Gao, Mark M Iles, David Timothy Bishop, Harriet Larvin, David Bunce, Bei Wu, Huabin Luo, Luigi Nibali, Susan Pavitt, Jianhua Wu, Jing Kang","doi":"10.1007/s00784-025-06286-5","DOIUrl":"10.1007/s00784-025-06286-5","url":null,"abstract":"","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"198"},"PeriodicalIF":3.1,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11926037/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143669339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of an artificial intelligence-based model in diagnosing periodontal radiographic bone loss.","authors":"Luanny de Brito Avelino Cassiano, Jordão Paulino Cassiano da Silva, Agnes Andrade Martins, Matheus Targino Barbosa, Katryne Targino Rodrigues, Ádylla Rominne Lima Barbosa, Gabriela Ellen da Silva Gomes, Paulo Raphael Leite Maia, Patrícia Teixeira de Oliveira, Maria Luiza Diniz de Sousa Lopes, Ivanovitch Medeiros Dantas da Silva, Ana Rafaela Luz de Aquino Martins","doi":"10.1007/s00784-025-06283-8","DOIUrl":"https://doi.org/10.1007/s00784-025-06283-8","url":null,"abstract":"<p><strong>Objective: </strong>To develop an artificial intelligence model based on convolutional neural network for detecting and measuring periodontal radiographic bone loss (RBL).</p><p><strong>Materials and methods: </strong>Keypoint annotations were carried out in 595 digital bitewing radiographic images using a Computer Vision Annotation Tool. The dataset was splitted: 416 of these images were trained using the You Only Look Once version 8 architecture with pose estimation (YOLO-v8-pose), 119 images were destined for the validation set, and 60 images were used for the test set, resulting in a model capable of detecting keypoints related to the cementoenamel junction (CEJ) and alveolar bone crest (ABC). In order to evaluate the performance of the obtained model, the following metrics were analyzed: F1-Score, precision, sensitivity and mean average precision (mAP). Then, an algorithm was implemented to measure the RBL by calculating the Euclidean distance between CEJ and ABC.</p><p><strong>Results: </strong>The model achieved an F1-Score of 66,89%, precision of 61,1%, a sensitivity of 73,9% and an mAP of 73.8%.</p><p><strong>Conclusions: </strong>The developed model and its algorithm for identifying and measuring periodontal radiographic bone loss demonstrated promising performance, thereby presenting a potential tool for assisting in periodontal diagnosis. Further studies comparing the developed model with manual measurements performed by specialists are necessary for its validation.</p><p><strong>Clinical relevance: </strong>Applying artificial intelligence in clinical dental practice can support diagnosis, streamline clinical workflows, and inform treatment planning, representing a significant advancement in dental automation.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"195"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mussel-inspired remineralizing agent: effects on morphology and permeability of dentin after erosion and abrasion cycling protocol.","authors":"Joyce Figueiredo de Lima Marques, Milagros Falcon Aguilar, Waldemir Francisco Vieira-Junior, Vanessa Gallego Arias Pecorari, Klaus Rischka, Flávio Henrique Baggio Aguiar","doi":"10.1007/s00784-025-06276-7","DOIUrl":"https://doi.org/10.1007/s00784-025-06276-7","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effects on morphology and permeability of dentin after an erosive and abrasive cycling protocol followed by treatment with an experimental solution containing dopamine.</p><p><strong>Materials and methods: </strong>Dentin hypersensitivity was simulated in human dentin discs by applying EDTA for 5 min. After assessing maximum dentin permeability (initial), specimens were randomly allocated into four groups: distilled water (control), NaF 0.05% solution, a commercial solution (Colgate^® Sensitive Pró-AlívioTM), or an experimental solution containing dopamine and laccase (n = 15). An erosive/abrasive cycling protocol was applied, including 0.3% citric acid for 2 min 4x/day, brushing for 5 s 2x/day, treatments for 5 min 2x/day. Dentin permeability was reassessed (final). Percentage permeability for each time point was calculated relative to maximum permeability (%Lp) and analyzed by generalized linear mixed models (α = 0.05). Surface effects were analyzed by scanning electron microscopy.</p><p><strong>Results: </strong>A significant reduction in permeability occurred in all groups post-cycling and treatment (p < 0.05), with no significant differences between groups (p = 0.6082). All groups exhibited sparse surface deposits, with few occluded tubules. Tubules appeared smaller in diameter in the Colgate^® and experimental solution groups, while distilled water and NaF groups showed more open tubules.</p><p><strong>Conclusion: </strong>In this model, dopamine demonstrated a limited effect, showing no significant protection of the dentin surface or reduction in permeability, similar to the other tested solutions.</p><p><strong>Clinical relevance: </strong>Changes in the habits of modern society have increased the prevalence of tooth wear and dentin hypersensitivity. In this context, it is essential to develop not only new active ingredients to prevent or minimize mineral loss but also new treatment methods.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"193"},"PeriodicalIF":3.1,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}