Clinical Oral Investigations最新文献

{"title":"Assessing the performance of an artificial intelligence based chatbot in the differential diagnosis of oral mucosal lesions: clinical validation study.","authors":"Nadav Grinberg, Sara Whitefield, Shlomi Kleinman, Clariel Ianculovici, Gilad Wasserman, Oren Peleg","doi":"10.1007/s00784-025-06268-7","DOIUrl":"https://doi.org/10.1007/s00784-025-06268-7","url":null,"abstract":"<p><strong>Objectives: </strong>Artificial intelligence (AI) is becoming more popular in medicine. The current study aims to investigate, primarily, if an AI-based chatbot, such as ChatGPT, could be a valid tool for assisting in establishing a differential diagnosis of oral mucosal lesions.</p><p><strong>Methods: </strong>Data was gathered from patients who were referred to our clinic for an oral mucosal biopsy by one oral medicine specialist. Clinical description, differential diagnoses, and final histopathologic diagnoses were retrospectively extracted from patient records. The lesion description was inputted into ChatGPT version 4.0 under a uniform script to generate three differential diagnoses. ChatGPT and an oral medicine specialist's differential diagnosis were compared to the final histopathologic diagnosis.</p><p><strong>Results: </strong>100 oral soft tissue lesions were evaluated. A statistically significant correlation was found between the ability of the Chatbot and the Specialist to accurately diagnose the cases (P < 0.001). ChatGPT demonstrated remarkable sensitivity for diagnosing urgent cases, as none of the malignant lesions were missed by the chatbot. At the same time, the specificity of the specialist was higher in cases of malignant lesion diagnosis (p < 0.05). The chatbot performance was reliable in two different events (p < 0.01).</p><p><strong>Conclusion: </strong>ChatGPT-4 has shown the ability to pinpoint suspicious malignant lesions and suggest an adequate differential diagnosis for soft tissue lesions, in a consistent and repetitive manner.</p><p><strong>Clinical relevance: </strong>This study serves as a primary insight into the role of AI chatbots, as assisting tools in oral medicine and assesses their clinical capabilities.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"188"},"PeriodicalIF":3.1,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical applications and classification of calcium silicate-based cements based on their history and evolution: a narrative review.","authors":"Kenta Tsuchiya, Salvatore Sauro, Hidehiko Sano, Jukka P Matinlinna, Monica Yamauti, Shuhei Hoshika, Yu Toida, Rafiqul Islam, Atsushi Tomokiyo","doi":"10.1007/s00784-025-06274-9","DOIUrl":"https://doi.org/10.1007/s00784-025-06274-9","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this narrative review was to analyze the evolution of the calcium silicate-based cement (CSC) products since 1993 and classify them to better understand their appropriate use in clinical practice and foster innovation in dental material development.</p><p><strong>Materials and methods: </strong>A narrative review of the relevant literature was conducted, collecting findings from computerized databases (PubMed, Science Direct, SCOPUS, and Web of Science) to provide historical background, classification, and modifications of CSCs published between 1993 and 2024.</p><p><strong>Results: </strong>We classified CSCs into six distinct generations based on previous literature. This classification revealed that the improvement in CSC's drawbacks, especially in physio-chemical properties, have led to the development of novel CSCs products. It also exhibited little to no variation in the bioactivity of CSCs across different generations and raised concerns regarding the biocompatibility of resin-modified CSC.</p><p><strong>Conclusions: </strong>No CSC has yet emerged as a potential gold-standard material for endodontic treatments. Therefore, clinical applications tailored to the characteristics of each generation of CSCs are essential. Future advancements are anticipated to enable CSCs to induce the regeneration of tissues such as dentin, cementum, periodontal ligament, and dental pulp by incorporating regulatory signals.</p><p><strong>Clinical relevance: </strong>This comprehensive classification system would assist clinicians in choosing the appropriate CSCs for various clinical situations by considering critical factors. This systematic approach enables clinicians to rely on evidence-based material selection rather than marketing claims. Furthermore, the insights into their evolution, classification, and clinical applications would fill a knowledge gap for clinicians and researchers.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"187"},"PeriodicalIF":3.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In-patient comparison of marginal bone loss after 4 months in immediately loaded, submucosal, and transmucosal dental implants using 3D scanning: a prospective clinical trial.","authors":"Armin Sokolowski, Martin Lorenzoni, Elisabeth Steyer, Felix Marschner, Anke Pichler, Alwin Sokolowski","doi":"10.1007/s00784-025-06255-y","DOIUrl":"10.1007/s00784-025-06255-y","url":null,"abstract":"<p><strong>Objectives: </strong>This prospective observational study aimed to evaluate the clinical outcomes and impact of different treatment protocols - immediate loading using a round gold bar retained overdenture on two implants, submucosal healing, and transmucosal healing - on circumferential marginal bone levels around dental implants.</p><p><strong>Materials and methods: </strong>20 patients requiring six implants in the edentulous lower jaw were included. Within each patient, 2 implants were assigned to submucosal healing, transmucosal healing, or immediate loading protocols. Marginal bone loss (MBL) was evaluated using 3D scanning at implant placement and after 4 months while raising a full-thickness flap. Periotest values (PTVs), the oral health impact profile (OHIP-14) and regular clinical evaluations were conducted for up to 2 years.</p><p><strong>Results: </strong>The submucosal group exhibited the least mean vertical MBL (-0.22 mm), significantly lower than the immediate (-0.39 mm) and transmucosal (-0.36 mm) groups (P = .001). Peri-implant bone surface area reduction was lowest in the submucosal group (-0.87 mm²) compared to the transmucosal (-4.58 mm²) and immediate (-6.66 mm²) protocols (P = .002). One submucosal healed implant and two immediately loaded implants were lost. Immediate loading provided high patient comfort and demonstrated successful outcomes both in terms of clinical data (PTVs, MBL) and patient-reported outcome measures (OHIP-14, VAS).</p><p><strong>Conclusions: </strong>Submucosal and transmucosal healing protocols resulted in better marginal bone preservation compared to immediate loading. Although immediate loading enhanced patient comfort, it was associated with higher marginal bone loss.</p><p><strong>Clinical relevance: </strong>This study highlights the potential advantages of submucosal healing for marginal bone preservation and supports the use of three-dimensional scanning for precise bone loss evaluation, guiding clinical decision-making in implantology.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov Identifier: NCT06408506.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"186"},"PeriodicalIF":3.1,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11914237/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143646859","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vitro analysis of various mouthwashes: cytotoxic, apoptotic, genotoxic and antibacterial effects.","authors":"Dilşah Çoğulu, Aslı Aşık, Sunde Yılmaz Süslüer, Ceren Yücel Er, Aslı Topaloğlu, Ataç Uzel, Cumhur Gündüz","doi":"10.1007/s00784-025-06261-0","DOIUrl":"10.1007/s00784-025-06261-0","url":null,"abstract":"<p><strong>Objective: </strong>This study aims to investigate the cytotoxic, apoptotic, and genotoxic effects of eleven mouthwashes, which are hypothesized to pose potential toxic risks to oral mucosal tissues, through in-vitro experiments using human gingival fibroblast(hGF) cell cultures and to compare the antibacterial efficacy of these mouthwashes.</p><p><strong>Materials and methods: </strong>Healthy hGF cell lines were derived from individuals under ethical standards. The cytotoxic effects of the mouthwashes (Colgate 2in1,Colgate Optic White, Colgate Plax, Curasept, Elmex, Kloroben, Listerine Cool Mint, Listerine Zero, Meridol, Oral-B Pro Expert, Sensodyne Pronamel) were assessed in real-time using the xCELLigence system, which monitored cellular activity at 5-minute intervals over 72 h. Apoptotic effects of the IC50 concentrations of the mouthwashes on hGF cells were evaluated using Annexin V and Caspase-3 assays. Genotoxic effects at IC50 concentrations were analyzed through the Alexa Fluor^® 488 Mouse anti-H2AX assay. The antibacterial effect of mouthwashes on Streptococcus mutans and Lactobacillus rhamnosus was evaluated by modified microdilution method.</p><p><strong>Results: </strong>According to the analysis of the IC50 values, Meridol was found to be the most cytotoxic mouthwash, while Listerine Zero was the least cytotoxic. The mouthwashes can be ranked in order of their cytotoxicity as follows: Meridol(0.011) > Elmex(0.029) > Colgate 2in1(0.187) > Colgate Plax(0.478) > Colgate Optic White (0.534) > Sensodyne Pronamel(0.577) > Oral-B Pro Expert(0.638) > Kloroben(0.766) > Curasept(1.872) > Listerine Cool Mint(2.334) > Listerine Zero(7.267)(p < 0.05). The Annexin V assay showed no major apoptotic impacts on human gingival fibroblast cell line at the IC50 values of the mouthwashes, except for Colgate Plax, Kloroben, and Oral B Pro Expert. The IC50 values of the evaluated mouthwashes did not show a significant apoptotic effect on the hGF cell line as evaluated by Caspase-3 assay and no significant genotoxic effect was observed as evaluated by H2AX assay(p > 0.05). Colgate Plax showed the most effective antibacterial effect on Streptococcus mutans and Lactobacillus rhamnosus(p < 0.05).</p><p><strong>Conclusion: </strong>Mouthwash formulations showed varying cytotoxic effects on hGF and different antibacterial effectiveness. Essential oil-containing mouthwashes may be preferable to those with chlorhexidine or cetylpyridinium chloride, as they demonstrate less cytotoxicity, are more biocompatible, and have antibacterial efficacy.</p><p><strong>Clinical relevance: </strong>The low cytotoxicity and potent antibacterial properties of essential oils render them a more safer choice for inclusion in mouthwash compositions.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"183"},"PeriodicalIF":3.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In vivo reproducibility of tooth shade determination on intraoral scans compared to the dental spectrophotometric method.","authors":"Louisa Kupke, Christian Schwahn, Karl-Friedrich Krey, Anja Ratzmann","doi":"10.1007/s00784-025-06240-5","DOIUrl":"10.1007/s00784-025-06240-5","url":null,"abstract":"<p><strong>Objective: </strong>The purpose of the study was to assess the reproducibility of the color analysis determination module of an intraoral scanner in comparison with spectrophotometric tooth color measurement concerning ΔE and d(0M1).</p><p><strong>Materials and methods: </strong>The color of teeth (13-23) of 35 participants was electronically measured with the intraoral scanner CEREC Primescan AC compared to the spectrophotometer VITA Easyshade V with positioning splints. VITA classical A1-D4® served as a reference system.</p><p><strong>Results: </strong>Concerning repeated measurements, both methods achieved comparable intra-method (very good) and inter-method (good) reproducibility in terms of ΔE and d(0M1) for statistics of agreement and reliability. Intra-method there were differences in favor of the spectrophotometer. For ΔE < 3.7 and d(0M1) < 2.7/< 3.7, both methods recorded excellent agreement. The standard error of measurement of the intraoral scanner was larger and the smallest detectable color difference was smaller for the spectrophotometer. The Bland-Altman plots showed a similar distribution.</p><p><strong>Conclusion: </strong>The intra- and inter-method reproducibility of tooth color measurement with the intraoral scanner was comparable to the spectrophotometric method.</p><p><strong>Clinical relevance: </strong>Tooth shade determination with intraoral scanners can be regarded as an alternative to spectrophotometric methods in clinical practice.</p><p><strong>Trial registration: </strong>Deutsches Register klinischer Studien (DRKSID DRKS00025498, registration date 16.07.2021).</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"185"},"PeriodicalIF":3.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633713","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Surface modification of polyether ether ketone (PEEK) via sulfonation and hydroxyapatite coating: impact on shear bond strength with resin composite.","authors":"Thae Phyu Htay, Chaimongkon Peampring, Putsadeeporn Thammajaruk","doi":"10.1007/s00784-025-06256-x","DOIUrl":"https://doi.org/10.1007/s00784-025-06256-x","url":null,"abstract":"<p><strong>Purpose: </strong>This study evaluates the effects of various polyetheretherketone (PEEK) surface treatments on its shear bond strength (SBS) with flowable resin composite.</p><p><strong>Methods: </strong>A total of 120 PEEK disks were categorized into five groups: untreated PEEK (control), sandblasted with 50 μm alumina (Sa PEEK), etched with 98% sulfuric acid for 1 min (S PEEK), hydroxyapatite-coated sulfonated PEEK (HA PEEK), and phosphoric acid-etched HA-coated PEEK (HAP PEEK). Each group was subdivided into two groups (n = 12): Scotchbond Universal Plus (Scb) and Single Bond Universal (Sib) adhesive application and bond with flowable resin composite. SBS was evaluated after thermocycling for 5000 cycles and the results were analyzed using two-way and one-way ANOVA, followed by Tukey's HSD (α = 0.05). Failure mode was analyzed using light and scanning electron microscope. Surface roughness and contact angle analysis of each surface treatment were also done.</p><p><strong>Results: </strong>HA PEEK exhibited the highest SBS in both Scb and Sib, while untreated PEEK showed the lowest. The effect of bonding agent can be seen only in S PEEK group where Sib demonstrated significantly higher SBS (P < 0.05) than Scb. Cohesive and mixed failures were observed in HA PEEK and HAP PEEK groups and others showed mostly adhesive failure. The wettability of PEEK increased after surface treatment except for Sa PEEK.</p><p><strong>Conclusions: </strong>HA PEEK consistently achieved the highest SBS, indicating that combining sulfonation with HA coating is an effective strategy to enhance bonding between PEEK and flowable resin composite.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"184"},"PeriodicalIF":3.1,"publicationDate":"2025-03-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143633650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anti-inflammatory and antimicrobial efficacy of coconut oil for periodontal pathogens: a triple-blind randomized clinical trial.","authors":"Simón Pardiñas López, Mónica E García-Caro, Juan A Vallejo, Pablo Aja-Macaya, Kelly Conde-Pérez, Paula Nión-Cabeza, Ismael Khouly, Germán Bou, Ana Isabel Rodríguez Cendal, Silvia Díaz-Prado, Margarita Poza","doi":"10.1007/s00784-025-06267-8","DOIUrl":"10.1007/s00784-025-06267-8","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the effect of coconut oil on the oral bacteriome and inflammatory response in patients with periodontitis by integrating next-generation sequencing analyses of pathogenic bacterial shifts and quantification of inflammatory markers, thereby assessing its potential as a natural adjunct to standard nonsurgical periodontal therapy.</p><p><strong>Materials and methods: </strong>A triple-blind clinical trial was conducted with 30 participants diagnosed with periodontitis, randomized into 3 groups: (1) coconut oil, (2) chlorhexidine and (3) placebo. Saliva and gingival crevicular fluid (GCF) samples were collected before treatment, one month after treatment, and one month post-non-surgical periodontal therapy. Bacterial DNA was extracted, and the V3-V4 region of the 16 S rRNA gene was PCR-amplified and sequenced using Illumina MiSeq technologies. Inflammatory biomarkers, including Interleukin-6 (IL-6) and tumor necrosis factor-alpha (TNF-α), were quantified from GCF samples.</p><p><strong>Results: </strong>Coconut oil treatment significantly reduced pathogenic bacterial families such as Spirochaetaceae and Tannerellaceae while promoting beneficial bacteria such as Streptococcaceae. At the genus and species levels, coconut oil reduced pathogens such as Tannerella forsythia and Treponema denticola along with increase in beneficial bacteria such as Streptococcus. The subgingival microbial dysbiosis index improved significantly in both coconut oil and chlorhexidine groups. Furthermore, the coconut oil demonstrated a reduction in IL-6 and TNF-α levels, indicating decreased local inflammation.</p><p><strong>Conclusions: </strong>Coconut oil treatment significantly modulated the oral microbiome and reduced inflammatory markers in patients with periodontitis, suggesting its potential as a natural and effective adjunct in periodontal therapy.</p><p><strong>Clinical relevance: </strong>This study highlights coconut oil's potential as a natural adjunct in periodontal therapy, effectively reducing pathogenic bacteria and inflammatory markers (IL-6, TNF-α). It offers a safe alternative to chlorhexidine, promoting microbiome balance and improved periodontal health.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"182"},"PeriodicalIF":3.1,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11909057/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630180","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retreatment or replacement of previous endodontically treated premolars with recurrent apical periodontitis? An 8-year historical cohort study.","authors":"Fausto Zamparini, Andrea Spinelli, Jacopo Lenzi, Ove A Peters, Maria Giovanna Gandolfi, Carlo Prati","doi":"10.1007/s00784-025-06238-z","DOIUrl":"10.1007/s00784-025-06238-z","url":null,"abstract":"<p><strong>Objectives: </strong>The study evaluated previously-endodontically-treated premolars affected by periapical lesions and/or secondary caries requiring a multidisciplinary decision between (non-surgical) retreatment or extraction and implant replacement over an 8-year minimum follow-up.</p><p><strong>Materials and methods: </strong>The decision-making was performed among a pool of patients attending a University Dental School. All patients presented at least one failing previously endodontically treated premolar. Recorded parameters were: structural conditions (residual coronal-structure, caries), periodontal and endodontic status (CEJ-MBL, initial-PAI, post-presence). Two experienced operators made the decision-making and classified teeth as retreatable and restorable (Endo-group) or suitable for extraction and implant replacement (Implant-group). Logistic regression and Cox-proportional-hazard analyses with clustered-standard-errors compared baseline-characteristics and treatment-outcomes. Odds-ratios (ORs) with 95% confidence-intervals (CIs) were reported for baseline-characteristics. Hazard-ratios (HRs) expressed the association of treatment-groups with time-to-event.</p><p><strong>Results: </strong>Ninety-six patients (n = 124 premolars) were enrolled (49 M;47 F; mean-age 53.1 ± 11.6 years). The decision-making splitted 54.8% treatments to Endo-group (n = 68) and 45.2% to Implant-group (n = 56). The 8-year survival were 85.1% for Endo-group and 98.2% for Implant-group. The 8-year success were 80.5% and 93.9%. The HR from Cox regression favored Implant-group (HR = 0.12, P = 0.049). The Endo-group showed the highest number of critical complications (15%) due to fractures, despite the healing of lesions. Implant-group had a higher percentage of minor prosthetic complications (14%).</p><p><strong>Conclusions: </strong>Endo-group demonstrated higher percentage of critical complications compared to Implant-group during the follow-up. Root fractures were accounted as main responsible, while periapical disease did not affect healing, survival and clinical longevity.</p><p><strong>Clinical significance: </strong>Insufficient crown structure was the major parameter associated with root fracture. In these cases, implant replacement strategy represented an adequate therapy justified by the higher success compared to root canal retreatment.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"181"},"PeriodicalIF":3.1,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11903559/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical performance of long-term temporary fixed dental prostheses fabricated from CAD/CAM resin-based composite.","authors":"Florian Dold, Karolina Mueller, Martin Butz, Sebastian Hahnel","doi":"10.1007/s00784-025-06259-8","DOIUrl":"10.1007/s00784-025-06259-8","url":null,"abstract":"<p><strong>Objectives: </strong>To determine the clinical performance of long-term temporary fixed dental prostheses (LTFDPs) manufactured from CAD/CAM temporary resin-based composite.</p><p><strong>Materials and methods: </strong>Retrospective data of 46 patients supplied with 73 LTFDPs (partial coverage crowns, crowns, fixed dental prostheses) manufactured from a CAD/CAM resin-based composite luted either temporarily, selfadhsesively, or adhesively were analyzed for failures and complications.</p><p><strong>Results: </strong>Datasets of 44 patients with 71 LTFDPs (12 partial-coverage crowns, 31 crowns, 28 fixed dental prostheses) were included in the analyses; median observation time was 362.0 days. Failures due to fracture occurred in 14.1% and decementation was observed in 18.1% of all LTFDPs. There was no statistically significant difference in failure rates between partial coverage crowns, crowns, and fixed dental prostheses. The probability of decementations was significantly higher in restorations that had been luted temporarily or selfadhesively than in those that had been luted adhesively.</p><p><strong>Conclusions: </strong>LTFDPs fabricated from resin-based temporary composite with low filler content feature relevant failure rates, which is independent on the type of restoration. Decementation is a frequently observed complication and dependent on the mode of luting.</p><p><strong>Clinical relevance: </strong>LTFDPs fabricated from resin-based composite have similar failure rates as reported for polymethyl methacrylate based LTFPDs. Adhesive luting might help to reduce the probability of decementation.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"179"},"PeriodicalIF":3.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11897085/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protective role of calcium-based agents in dental bleaching gels: insights from a systematic review and meta-analysis of clinical and laboratory evidence.","authors":"Gabriel Pereira Nunes, Renata de Oliveira Alves, Geórgia Rondó Peres, Matheus Henrique Faccioli Ragghianti, Priscila Toninatto Alves de Toledo, Alexandre Henrique Dos Reis Prado, Carla Ferreira-Baptista, Alberto Carlos Botazzo Delbem","doi":"10.1007/s00784-025-06265-w","DOIUrl":"https://doi.org/10.1007/s00784-025-06265-w","url":null,"abstract":"<p><strong>Objectives: </strong>This systematic review and meta-analysis (SRM) evaluated the effect of incorporating calcium-based bioactive agents in bleaching gels on dental structure preservation and whitening efficacy.</p><p><strong>Methods: </strong>A comprehensive search was conducted across databases up to November 2024. Two independent reviewers screened and selected clinical trials and in vitro studies evaluating the effects of calcium-based bioactive agents in bleaching gels, following predefined PICO criteria. Data extraction and quality assessments were performed using the Cochrane Collaboration tool and Joanna Briggs Institute Critical Appraisal Tools. Meta-analyses were conducted with RevMan software, using the mean difference as the effect measure.</p><p><strong>Results: </strong>Out of 4,289 articles identified, 56 met the inclusion criteria, consisting of 50 in vitro studies and 6 clinical trials. The agents evaluated included calcium ions, calcium gluconate, amorphous calcium phosphate, CPP-ACP, and calcium polyphosphate. Overall, all agents reduced the adverse effects associated with bleaching therapy, such as minimizing changes in the mechanical and morphological properties of enamel, reducing transamelodentinal diffusion, and clinically decreasing tooth sensitivity. None of the calcium-based agents interfered with the bleaching effect. In short, the studies demonstrated a low risk of bias.</p><p><strong>Conclusions: </strong>Calcium-based agents incorporated into bleaching gels reduced bleaching-induced changes in dental tissues and demonstrated clinical aesthetic results comparable to conventional gels. However, further clinical trials are needed to optimize formulations, application protocols, and confirm the findings of this study.</p><p><strong>Clinical relevance: </strong>This SRM provides evidence that these agents offer additional benefits by enhancing the biocompatibility and safety of whitening therapy over conventional treatments, guiding clinicians in material selection for whitening procedures.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 4","pages":"180"},"PeriodicalIF":3.1,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143613776","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}