Clinical Oral Investigations最新文献

{"title":"Assessment of accuracy and efficiency of guided fixation of customized 3D miniplates vs Champy's technique in stabilization of mandibular angle fractures: A randomized controlled trial.","authors":"Arwa Hosni, Mohamed Shawky, Mohamed Ibrahim Sakr, Waleed El-Beialy, Mostafa Ezz, Mohammed Atef","doi":"10.1007/s00784-026-07118-w","DOIUrl":"10.1007/s00784-026-07118-w","url":null,"abstract":"<p><strong>Objectives: </strong>The objectives of this study were; (1) to assess the accuracy of virtual surgical planning (VSP) and computer aided design and manufacturing (CAD/CAM) in creating an anatomically oriented, bone-borne fracture reduction/plate positioning patient specific surgical guide (PSSG) and a customized three-dimensional (3D) miniplate to achieve anatomical reduction and stabilization of fractured segments in mandibular angle fractures (MAF) via a more esthetic, less complication-laden intraoral access, and (2) to evaluate efficiency of customized 3D miniplates in reestablishment of masticatory function.</p><p><strong>Methods: </strong>Twenty-four patients were included and randomly allocated into 2 groups; group I, where open reduction and internal fixation (ORIF) of MAF was performed using a fracture reduction/plate positioning PSSG and a customized 3D miniplate and group II, where ORIF of MAF was performed using a single 2.0 superior border miniplate (Champy's technique). Assessment of accuracy of VSP in group I was carried out by superimposition of 3D virtual models of virtually preoperatively reduced mandible over those of surgically reduced and stabilized mandibles at 1 week and 6 months postoperatively. Clinical assessments of maximum bite force in Newtons (N) using a bite force measurement device as well as occlusion status according to the following scale: satisfactory (no gap), mild derangement (gap of 1-2 mm) or marked derangement (gap more than 2 mm) were carried out at 1 week, 1, 3 and 6 months postoperatively.</p><p><strong>Results: </strong>In group I, superimposition of 3D virtual models of surgically reduced and stabilized mandibles at 1 week and 6 months over the virtually preoperatively reduced mandible revealed a mean surface deviation of 0.36 ± 0.09 mm and 0.45 ± 0.08 mm, respectively. Bite force measurements in group I were significantly higher (p < 0.001) than those in group II at 1 week (20.48 ± 3.20N-13.24 ± 2.83N), 1 month (69.52 ± 3.42N-41.16 ± 3.02N) and 3 months (147.45 ± 3.00N-139.50 ± 3.44N), respectively, with large effect sizes (PES > 0.29). At six months, there was also a statistically significant difference (p = 0.003) between both groups (166.66 ± 2.8N-162.31 ± 3.19N respectively) with higher bite force in group I, however, the effect size was moderate (PES = 0.13). Difference in postoperative occlusion status was statistically insignificant between both groups across all time points.</p><p><strong>Conclusion: </strong>Assessment of accuracy of VSP revealed a minimal amount of discrepancy between 3D virtual models of surgically reduced and stabilized mandibles over those of virtually preoperatively reduced mandibles. An anatomically oriented, bone-borne fracture reduction/plate positioning PSSG aided significantly in customized 3D miniplate positioning and fracture reduction. Fractures stabilized with a customized 3D miniplate were associated with higher bite forces when compared to single m","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633161/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105056","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Modality-specific quantitative radiologic characterization of diffuse sclerosing osteomyelitis of the mandible: a pilot study.","authors":"Katharina Theresa Obermeier, Wenko Smolka, Sven Otto, Anusha Abdullah, Gabriele Kaeppler, Eric Hesse, Ina Dewenter, Yoana Malenova","doi":"10.1007/s00784-026-07160-8","DOIUrl":"10.1007/s00784-026-07160-8","url":null,"abstract":"<p><strong>Objectives: </strong>Diffuse sclerosing osteomyelitis (DSO) of the mandible is a rare chronic inflammatory disease characterized by recurrent painful swelling and trismus. While advanced stages are known to show radiographically evident bone sclerosis, objective quantitative imaging criteria remain poorly defined. This study aimed to characterize modality-specific radiological features of DSO using intra-individual side-to-side comparison of bone density and cortical thickness.</p><p><strong>Materials and methods: </strong>This single-center retrospective study included 22 patients treated for DSO between 2010 and 2021. Pre-treatment panoramic radiographs were available for all patients, CT datasets for 6 patients, and CBCT for 3 patients. Bone density was quantified using relative grayscale values in panoramic radiography, Hounsfield units (HU) in CT, and gray values in CBCT. Cortical thickness was measured on CT using standardized regions of interest, with contralateral-side comparison. Two blinded observers performed all measurements.</p><p><strong>Results: </strong>Quantitative analysis demonstrated significantly higher bone density on the affected side in panoramic radiography and CT (panoramic: 46.0 ± 4.0% vs. 39.0 ± 3.6%, p < 0.001; CT: 1220.9 ± 215.8 HU vs. 1108.0 ± 163.9 HU, p = 0.01). In the three available CBCT datasets, descriptively higher gray values were observed on the affected side. CT analysis revealed significantly increased cortical thickness (5.63 ± 0.96 mm vs. 3.86 ± 0.75 mm, p = 0.04). A blurred inferior alveolar nerve canal was consistently observed on panoramic radiographs.</p><p><strong>Conclusions: </strong>Quantitative side-to-side assessment provides an objective radiological description of DSO and may support imaging assessment when interpreted together with clinical and histopathological findings.</p><p><strong>Clinical relevance: </strong>In this selected cohort, DSO-affected regions showed relative densification, cortical thickening in the available CT examinations, and blurring of the inferior alveolar nerve canal on panoramic radiographs.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633303/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Condylar Bone Remodeling After TMJ Disc Repositioning Using Sutureless Screws Versus Suture Anchors for Anterior Disc Displacement Without Reduction: A Prospective Cohort Study.","authors":"Chunmei Li, Xingyu Lyu, Jiannan Zhao, Zhipeng Wang, Nan Jiang, Yiru Wang, Pinyin Cao","doi":"10.1007/s00784-026-07195-x","DOIUrl":"10.1007/s00784-026-07195-x","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;Temporomandibular joint (TMJ) disc repositioning is an effective treatment for anterior disc displacement without reduction (ADDWoR). This study aimed to evaluate the 12-month bone remodeling outcomes following sutureless repositioning screw fixation and to explore whether there is a significant difference in condylar bone remodeling compared with suture anchor fixation.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;This single-center prospective cohort study included patients with MRI-confirmed ADDWoR who underwent TMJ disc repositioning and fixation between June 2022 and December 2024. Patients were categorized into the sutureless repositioning screw group and the suture anchor group according to the fixation method. All patients underwent cone-beam computed tomography preoperatively (T0) and after 12 months postoperatively (T1). The primary outcome was condylar height. Secondary outcomes included condylar length and width; anterior, superior, and posterior joint spaces; glenoid fossa thickness; condylar osseous degeneration score; assessment of condylar osseous changes; and new bone formation. Continuous postoperative outcomes were analyzed using linear mixed-effects models with a patient-level random intercept, adjusting for the corresponding baseline value, age group, and fixation technique. Generalized estimating equations with patient-level clustering were used for the osseous degeneration score and binary remodeling outcomes. Age-by-technique interactions were additionally examined.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 69 patients (102 TMJs) were included, comprising 36 patients (55 joints) treated with sutureless repositioning screws and 33 patients (47 joints) treated with suture anchors. Both groups demonstrated favorable postoperative osseous remodeling over 12 months. In adjusted mixed-effects models, fixation technique was not independently associated with condylar height or any secondary continuous outcome. For the primary outcome, neither age group (β=0.237, 95% CI -0.068 to 0.542; P=0.128) nor fixation technique (β=0.192, 95% CI -0.104 to 0.489; P=0.204) was significantly associated with condylar height at T1. Age was independently associated with greater glenoid fossa thickness (β=0.408, 95% CI 0.137 to 0.678; P=0.003), a lower postoperative osseous degeneration score (β=-0.614, 95% CI -0.882 to -0.345; P&lt;0.001), and higher odds of osseous improvement (OR=4.699, 95% CI 1.650 to 13.379; P=0.004). The association between age and new bone formation did not reach statistical significance (OR=3.168, 95% CI 0.958 to 10.473; P=0.059). No significant age-by-technique interaction was observed for any evaluated outcome.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Sutureless repositioning screw fixation achieved reliable condylar bone remodeling outcomes at the 12-month follow-up, with no independent difference detected compared with suture anchor fixation after adjustment. Age may be associated with selected postoperative bo","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105063","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary metabolic profile in patients with oral squamous cell carcinoma and potentially malignant disorders.","authors":"Lauriina Soiniemi, Eelis Hyvärinen, Jopi Mikkonen, Heli Jäsberg, Bina Kashyap, Arja Kullaa","doi":"10.1007/s00784-026-07192-0","DOIUrl":"10.1007/s00784-026-07192-0","url":null,"abstract":"<p><strong>Objectives: </strong>Oral Potential Malignant Lesions (OPMDs), including oral leukoplakia (OLK) and lichen planus (OLP), as well as Oral Squamous Cell Carcinoma (OSCC) are influenced by oral dysbiosis and might represent a disease continuum. Our hypothesis was that the oral salivary metabolomic reflects the association of those diseases. Hence, we aimed to study and compare salivary metabolites and metabolic pathways in OPMDs and OSCC.</p><p><strong>Material and methods: </strong>Unstimulated saliva samples were collected from 60 participants: OLK (n = 15), OLP (n = 15), OSCC (n = 15), and healthy controls (HCs; n = 15). Metabolites were quantified using NMR spectroscopy, and pathway analyses were performed with MetaboAnalyst 6.0.</p><p><strong>Results: </strong>Four metabolites (acetate, taurine, pyruvate, methylamine) were elevated, while proline was consistently decreased in all disease groups relative to HCs. Four key pathways were altered: pyruvate metabolism (in all disease groups), glutamate metabolism (in OLK and OSCC), taurine and hypotaurine metabolism (in OLP and OLK), and the glucose-alanine cycle. OLK shared more metabolic features with OSCC than with OLP.</p><p><strong>Conclusions: </strong>Salivary metabolomic profiling reveals distinct metabolic alterations across OPMDs and OSCC, supporting their potential continuum and reflecting disease-related biochemical reprogramming. These findings highlight salivary metabolomics as a promising, non-invasive tool for understanding pathogenesis and for future development of biomarkers.</p><p><strong>Clinical relevance: </strong>Divergent metabolic pathways in OLP and OLK may relate to their different pathogenesis and malignant transformation risks. Improved understanding of these pathways may support early diagnostics and targeted therapeutic strategies.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633301/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-term radiographic changes of extruded NeoSealer Flo in a simulated enlarged-apex model: influence of moisture and periapical support.","authors":"Andrea Spinelli, Valentina Pergola, Carlo Prati, Maria Giovanna Gandolfi, Fausto Zamparini","doi":"10.1007/s00784-026-07175-1","DOIUrl":"10.1007/s00784-026-07175-1","url":null,"abstract":"<p><strong>Objectives: </strong>To radiographically evaluate short-term changes in NeoSealer Flo extruded beyond enlarged apical preparations under different moisture and apical-support conditions.</p><p><strong>Materials and methods: </strong>Thirty-two extracted single-rooted human teeth were randomly allocated to four experimental conditions (n = 8 per group). Teeth were prepared with reciprocating NiTi instruments to size 50/0.05 and filled with a matched gutta-percha cone and a premixed bioceramic sealer. The conditions combined the presence or absence of sponge support around the apex with dry or phosphate-buffered saline PBS-moistened canals. Standardized radiographs were acquired immediately after filling (T0), at 7 days (T1), and at 28 days (T2). Intracanal radiopaque area (Area of the canal, AOC) and apically extruded radiopaque area (Area of Extrusion, AE) were traced within a calibrated 6 × 10-mm region of interest. Separate random-intercept linear mixed models included group, time, and their interaction; pairwise comparisons used Sidak adjustment.</p><p><strong>Results: </strong>Mean AOC changed by no more than 0.56 mm² within groups. The group-by-time interaction was not significant for AOC (Wald χ²(6) = 5.31, p = 0.505) but was significant for AE (Wald χ²(6) = 21.72, p = 0.001). From T0 to T2, mean AE changed by + 3.38 mm² (Group 1; dry/sponge), + 0.25 mm² (Group 2; moist/sponge), + 1.50 mm² (Group 3; dry/no sponge), and + 0.41 mm² (Group 4; moist/no sponge).</p><p><strong>Conclusions: </strong>Intracanal radiopaque area remained relatively stable over 28 days, whereas the extruded radiopaque area differed among experimental conditions. The largest mean increase occurred in the dry, sponge-supported group.</p><p><strong>Clinical relevance: </strong>Local moisture and periapical status may influence the radiopaque area of extruded NeoSealer Flo. However, the radiographic changes do not directly demonstrate material expansion, dissolution, resorption, or biological integration. Apical extrusion should be minimized in clinical practice.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13633336/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105136","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of different dental local anesthesia techniques on salivary cortisol and secretory immunoglobulin a in pediatric patients: a randomized controlled clinical study.","authors":"Hazar Baha Karadeniz, Peris Celikel, Esra Laloglu","doi":"10.1007/s00784-026-07187-x","DOIUrl":"10.1007/s00784-026-07187-x","url":null,"abstract":"<p><strong>Objectives: </strong>Dental local anesthesia may elicit acute stress-related responses in children. This study compared salivary cortisol and secretory immunoglobulin A (s-IgA) responses to conventional anesthesia, conventional anesthesia following topical anesthesia, jet anesthesia, and computer-controlled local anesthesia delivery system (CCLAD), and examined associations between the biomarkers.</p><p><strong>Materials and methods: </strong>80 healthy children aged 6-9 years were randomly assigned to four anesthesia groups (n = 20/group). Behavioural, physiological, and biochemical responses were assessed using MCDAS, Frankl, SEM, heart rate, salivary cortisol, and s-IgA. Saliva was collected before and after anesthesia and analysed using standardized procedures.</p><p><strong>Results: </strong>SEM scores increased during anesthesia in all groups (p < 0.05) and were lower with CCLAD than conventional anesthesia (p = 0.004). Cortisol increased after conventional (4.59 ± 2.45 to 6.07 ± 2.78 nmol/L; p < 0.001) and jet anesthesia (6.49 ± 4.42 to 8.07 ± 5.51 nmol/L; p = 0.007), but not after conventional anesthesia following topical anesthesia or CCLAD (p > 0.05). s-IgA decreased after conventional and jet anesthesia (p < 0.001), with no significant changes in the other groups. Baseline s-IgA concentrations differed among groups (p < 0.001). Changes in cortisol and s-IgA were negatively correlated in the conventional anesthesia following topical anesthesia and CCLAD groups (p < 0.001).</p><p><strong>Conclusion: </strong>Taken together, the findings indicate that local anesthesia protocols are associated with different behavioural and biochemical response patterns in pediatric patients. CCLAD was associated with lower procedural SEM scores, while salivary cortisol and s-IgA responses varied across protocols. These patterns should not be interpreted as evidence that any technique definitively reduces psychological stress. Salivary s-IgA may have potential as a complementary stress-related biomarker, although further studies are needed to establish its clinical applicability.</p><p><strong>Clinical relevance: </strong>CCLAD was associated with lower SEM scores during anesthesia compared with conventional anesthesia, while no significant pre-to-post changes in salivary cortisol or s-IgA were observed in the CCLAD or conventional anesthesia following topical anesthesia groups. These findings may inform the clinical selection of anesthesia protocols; however, changes in cortisol and s-IgA should be interpreted as stress-related biomarker responses rather than direct evidence of reduced psychological stress.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative ultrasonographic and clinical assessment of major salivary glands in patients with chronic kidney disease and healthy controls.","authors":"Selinay Sari Kurt, Melike Yurttaş, Neslihan Tezcan","doi":"10.1007/s00784-026-07185-z","DOIUrl":"10.1007/s00784-026-07185-z","url":null,"abstract":"<p><strong>Aim: </strong>The aim of this study was to compare the ultrasonographic characteristics and clinical findings of the major salivary glands between patients with chronic kidney disease (CKD) and healthy controls.</p><p><strong>Materials & methods: </strong>The study included 23 CKD patients undergoing dialysis and 20 healthy controls. The size and parenchymal homogeneity of the parotid and submandibular glands were evaluated using ultrasonography. Clinical assessments included the measurement of resting salivary flow rate, evaluation of xerostomia symptoms via the Xerostomia Inventory (XI), and determination of oral hygiene status using the DMFT index. Statistical analyses were conducted via Fisher's exact test, the independent samples t-test, the Mann Whitney U test, or the Kruskal-Wallis test.</p><p><strong>Results: </strong>The mean age of the CKD patients was 58 years, whereas that of the controls was 54 years. Approximate two-dimensional cross-sectional areas (ATCAs) of ​​the parotid and submandibular glands were significantly greater in CKD patients (p < 0.05). Submandibular gland heterogeneity was greater in the patient group (p < 0.05). The salivary flow rate tended to be lower in CKD patients, whereas DMFT scores and XI scores were higher. (p = 0.678, p = 0.062, and p = 0.009, respectively). Multiple regression analysis revealed that, independent of age, the gland ATCAs were significantly greater in patients than in controls.</p><p><strong>Conclusion: </strong>This study suggests that dimensional and structural changes may occur in the major salivary glands of CKD patients on dialysis. Significant differences in ATCAs of salivary glands and heterogeneity versus controls, independent of age, suggest that CKD may be associated with alterations in gland morphology. Although no significant differences were found in salivary flow rate or DMFT scores between groups, increased XI scores were observed in patients with CKD, suggesting a possible association between CKD and impaired oral health-related symptoms.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of post-curing level and phosphorylcholine modification on a 3D-printable resin for definitive crowns.","authors":"Engin Sacu, Neslihan Tekce, Ahmet Erdem, Duygu Cetin, Safa Tuncer, Mustafa Demirci","doi":"10.1007/s00784-026-07186-y","DOIUrl":"10.1007/s00784-026-07186-y","url":null,"abstract":"<p><strong>Objectives: </strong>This in vitro study evaluated the effects of 2 wt% 2-methacryloyloxyethyl phosphorylcholine (MPC) and post-curing level on degree of conversion, water sorption, and Bis-EMA release from a 3D-printable resin for definitive crowns.</p><p><strong>Materials and methods: </strong>VarseoSmile Crown plus and its 2 wt% MPC-modified formulation were fabricated by digital light processing and post-cured with 2 × 2000, 4 × 2000, or 8 × 2000 flashes. Degree of conversion and water sorption were evaluated in 10 specimens per group, and Bis-EMA release in 5. Degree of conversion was measured before and after 10,000 thermocycles by FTIR-ATR, water sorption after thermocycling, and Bis-EMA release at 24 h and 14 days by HPLC-UV. Statistical significance was set at α = 0.05.</p><p><strong>Results: </strong>Higher post-curing levels increased degree of conversion and reduced Bis-EMA release (P < 0.05), but did not affect water sorption (P = 0.294). MPC reduced degree of conversion and increased water sorption (P < 0.05), but did not affect 24-hour or cumulative 14-day Bis-EMA release (P = 0.130 and P = 0.083, respectively). Bis-EMA release from Lava Ultimate remained below the detection limit.</p><p><strong>Conclusions: </strong>Increasing post-curing improved polymerization and reduced Bis-EMA release. MPC reduced degree of conversion and increased water sorption without significantly affecting Bis-EMA release. After thermocycling, degree of conversion increased only at the lowest post-curing level.</p><p><strong>Clinical relevance: </strong>Appropriate post-curing may limit Bis-EMA release from definitive 3D-printed crowns. Although MPC modification was associated with lower degree of conversion and greater water sorption, the magnitude of the observed difference in degree of conversion may be of limited clinical relevance.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105079","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The oral und systemic health risks of sugar consumption: an umbrella review.","authors":"J P Woelber, N Wirth, A Dallmer-Zerbe, C Tennert","doi":"10.1007/s00784-026-07191-1","DOIUrl":"10.1007/s00784-026-07191-1","url":null,"abstract":"<p><strong>Objective: </strong>The recommendation of free sugar reduction in dental practice is mostly given with regard to caries prevention but has also further health impacts. This umbrella review aimed to comprehensively display the shared health consequences of sugar consumption in both oral and general health.</p><p><strong>Materials and methods: </strong>Within an umbrella review, two independent reviewers identified and analysed systematic reviews examining free sugar consumption alone or as a part of dietary patterns and its association to described diseases in three databases (Epistemonikos, Pubmed, Cochrane Library). Electronic databases were searched up to March 2026, findings were synthesised narratively. Risk of bias was assessed using AMSTAR-2.</p><p><strong>Results: </strong>The literature search identified 10,593 articles, of which 633 were further assessed for eligibility. Finally, 228 articles were included after full-text analysis. Results showed that sugar intake was consistently associated with increased risks of 18 generalised negative health outcomes. Strongest evidence was found for type 2 diabetes, obesity, cardiovascular and all-cause mortality, oral diseases, irritable bowel syndrome, and cognitive disorders. Furthermore, a positive association was found between excessive sugar consumption and cancer, non-alcoholic fatty liver disease, kidney disease, gout, asthma, poor sleep, reduced bone density, mood disorders, telomere shortening, and fertility impairments. AMSTAR-2 showed that most reviews had low or critically low methodological quality, while about one third demonstrated moderate to high confidence. Most studies (68%) investigated sugar in form of sugar-sweetened beverages.</p><p><strong>Conclusions: </strong>Within the limitations of this umbrella review, available evidence indicates that avoiding free sugar intake contributes to both reduced chronic disease burden and improved oral health. Against this background, avoiding free sugar, as recommended by dentists, is a key shared health factor that should be emphasized in the context of caries, periodontal disease, and in terms of general primary prevention.</p><p><strong>Clinical relevance: </strong>Dental advised and assisted sugar reduction is an important preventive measure not only for oral health but also for several general health outcomes. After synthesizing and evaluating the available systematic reviews, this study highlights the crucial need to reduce sugar consumption as an important factor in improving both systemic and oral health.</p><p><strong>Systematic review registration: </strong>The systematic review was registered in the international register for systematic reviews Prospero. Systematic review registration CRD42023380458.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627276/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of postoperative antibiotics in reducing complications following primary surgical closure of oroantral communications secondary to tooth extraction: a retrospective multicenter study.","authors":"Melih M Bakacak, Jean Pierre T F Ho, Erik H van der Meij, Willem H Schreuder, Johannes N Lodders","doi":"10.1007/s00784-026-07189-9","DOIUrl":"10.1007/s00784-026-07189-9","url":null,"abstract":"<p><strong>Objectives: </strong>Maxillary canine, premolar and molar extractions may result in oroantral communication (OAC). Surgical closure aims to prevent the development of a persistent oroantral fistula (OAF), thereby reducing the risk of maxillary sinusitis. There is no consensus regarding the benefit of the use of perioperative antibiotics. This study evaluated the effect of postoperative antibiotics on complications after primary OAC closure following tooth extraction.</p><p><strong>Materials and methods: </strong>Eligible patients were identified by retrospectively reviewing the medical records of patients who underwent surgical closure of an OAC at Amsterdam UMC-VUmc and Amsterdam UMC-AMC from 2000 to 2025. Among these patients, the associations of various exposures, including postoperative antibiotic use, with overall complications, infectious complications, and persistent OAF were assessed. Group differences were assessed using the chi-square and independent t-tests, while univariate and multivariable associations were assessed using logistic regression (p < 0.05). Number needed to be exposed to benefit (NNEB) and harm (NNEH) were calculated.</p><p><strong>Results: </strong>A total of 725 potentially eligible participants were identified, of whom 505 were eligible; 308 (61.0%) were male, and 251 (49.7%) received postoperative antibiotics. Overall complications occurred in 11.7%, infectious complications in 8.2%, and persistent OAF in 3.6%. Postoperative antibiotic use was significantly associated with fewer overall and infectious complications and fewer persistent OAFs. (NNEB 6.9, 6.9, and 21.4, respectively). Autoimmune disease and use of intra-alveolar hemostatic agent were associated with increased overall complications. Soft tissue (partial) impaction was associated with increased risk for infectious complications. Use of intra-alveolar hemostatic agent and soft tissue (partial) impaction were associated with increased risk for persistent OAF.</p><p><strong>Conclusion: </strong>Postoperative antibiotic use after primary OAC closure following tooth extraction was associated with reduced risk of overall and infectious complications and persistent OAFs. Prospective studies are needed to confirm these findings and guide antibiotic use.</p><p><strong>Clinical relevance: </strong>Oral healthcare professionals should be aware of the potential benefit of postoperative antibiotics in preventing complications. Therefore antibiotic prophylaxis could be considered in patients with obvious risk factors or if an uneventful outcome is highly desirable.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"30 10","pages":""},"PeriodicalIF":3.6,"publicationDate":"2026-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13627183/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}