Clinical Oral Investigations最新文献

{"title":"3-Dimensional topographic enamel surface changes after different debonding techniques for aligner attachments: a micro-CT study.","authors":"Hilal Turkoglu, Ezgi Atik","doi":"10.1007/s00784-025-06188-6","DOIUrl":"10.1007/s00784-025-06188-6","url":null,"abstract":"<p><strong>Introduction: </strong>To evaluate topographic changes of enamel surface in 3-dimensional after different debonding methods of aligner attachments formed with 2 different composite resins.</p><p><strong>Methods: </strong>Vertical rectangular attachments were created on 88 premolar teeth and divided into two composite resin groups (Group 1:flowable, Group 2:packable) (N = 44). These were then divided into two subgroups (N = 22) using different debonding methods. In Group A, the attachments were firstly removed using an attachment debonding plier and then with white fiberglass. Following, the tooth surfaces were polished with blue fiberglass. In Group B, the excess attachment composite was removed with a 12-blade carbide bur, followed by a 24-blade carbide bur, and tooth surfaces were polished with Renew stone. The remaining composite volume was measured using Geomagic Control X software. Enamel surface roughness and morphological change were compared between the groups.</p><p><strong>Results: </strong>Residual composite resin volume did not show a statistically significant difference between composite resin groups (1-2 A). The enamel demineralization volume and area changes in Group 2 A were significantly higher than observed in 2B (p < 0.05). Roughness parameters Ra (T1-T0), Ra (T2-T0), Rq (T1-T0), and Sa (T1-T0) were significantly higher in Group 1B compared to Group 1 A (p < 0.05). Similarly, Ra (T1-T0), Sa (T1-T0), and Sq (T1-T0) parameters were significantly higher in Group 2B compared to Group 2 A (p < 0.05).</p><p><strong>Conclusions: </strong>Fiberglass with a debonding plier produced a smoother enamel surface compared to carbide burs, but caused significantly more enamel demineralization, as seen in micro-CT evaluations after polishing.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"89"},"PeriodicalIF":3.1,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762567/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143037009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the risk of extrusion with laser-activated irrigation techniques in root canal systems: a cadaver-based study.","authors":"Patrick Sofer, Mehrnaz Tahmasbi, Feng-Ming Wang, Madhu Nair, Matthew Kesterke, Poorya Jalali","doi":"10.1007/s00784-025-06165-z","DOIUrl":"10.1007/s00784-025-06165-z","url":null,"abstract":"<p><strong>Objectives: </strong>The objective of this study is to evaluate the incidence and volume of contrast medium extrusion when activated with a laser and to compare these outcomes with those of other irrigation techniques.</p><p><strong>Materials and methods: </strong>Sixteen cadaver mandibles containing 116 single-rooted teeth were prepared using conventional rotary instrumentation. The teeth were randomly assigned to four irrigation groups: side-vented needle, sonic irrigation, laser activation at the orifice, and laser activation at the middle third of the canal. Gastrografin, an iodinated contrast medium, was used to simulate irrigants. Cone Beam Computed Tomography (CBCT) scans were obtained pre- and post-irrigation to assess the incidence and volume of extrusion. Two blinded observers evaluated the images for the presence or absence of extrusion. Data were statistically analyzed using ANOVA and chi-square tests.</p><p><strong>Results: </strong>The observers reached a consensus on 116 out of 116 cases, resulting in a percent agreement of 100%. None of the experimental groups, side-vented needle (n = 29), sonic irrigation (n = 29), laser activation at the orifice (n = 29), and laser activation in the middle third (n = 29), demonstrated any radiographic evidence of extrusion.</p><p><strong>Conclusion: </strong>This cadaver-based model, combined with CBCT, provides a clinically relevant assessment of irrigant behavior during endodontic treatment. While the findings from this study suggest that LAI at the orifice or in the middle third of the canal may be a safe method for enhancing irrigation in endodontics, clinicians should remain cautious regarding the potential risks of irrigant extrusion.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"81"},"PeriodicalIF":3.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028111","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Co-culture of Helicobacter pylori with oral microorganisms in human saliva.","authors":"Konstantin Johannes Scholz, Annabelle Höhne, Annette Wittmer, Georg Häcker, Elmar Hellwig, Fabian Cieplik, Barbara Waidner, Ali Al-Ahmad","doi":"10.1007/s00784-025-06160-4","DOIUrl":"10.1007/s00784-025-06160-4","url":null,"abstract":"<p><strong>Objective: </strong>Helicobacter pylori is known for colonizing the gastric mucosa and instigating severe upper gastrointestinal diseases such as gastritis, gastroduodenal ulcers, and gastric cancer. To date, there is no data available on the oral cavity as transmission site, whether H. pylori can survive in the oral cavity or in human saliva. The aim of the study was to investigate the influence of oral microorganisms and human saliva on the survival of H. pylori in human saliva.</p><p><strong>Methods: </strong>H. pylori strains KE, a motile derivate of type strain H. pylori 26695, and H. pylori SS1, a clinical isolate from a gastric biopsy, were grown in human pooled saliva (pooled from 4 healthy human donors, 0.22 μm filter-sterilized) or in BBF (Brucella browth formula; control) either as mono-cultures or in co-culture with Streptococcus mutans, Streptococcus oralis, Actinomyces naeslundii, Lacticaseibacillus casei and Candida dubliniensis. Bacterial survival of H. pylori and the oral microorganisms were investigated using colony forming units (CFU) assay and MALDI-TOF MS at baseline and after 24, 48 and 168 h.</p><p><strong>Results: </strong>In saliva, H. pylori KE demonstrated enhanced survival in co-culture with S. mutans, A. naeslundii, and C. dubliniensis, enduring for at least 48 h. In contrast, L. casei and S. oralis inhibited H. pylori KE in saliva. H. pylori KE could not be cultured after 168 h in saliva, neither in mono- nor co-culture. In contrast, H. pylori SS1 in saliva could be cultured after 168 h in co-culture with S. mutans and C. dubliniensis, but not in mono-culture. In BBF, H. pylori KE could be cultured after 168 h with S. mutans, L. casei and C. dubliniensis, and H. pylori SS1 with L. casei and C. dubliniensis, but not with S. mutans. Notably, the co-cultured microorganisms survived at high CFU numbers similar to those of the monocultures.</p><p><strong>Conclusion: </strong>The study suggests that H. pylori can transiently survive in human saliva and even with presence of certain oral microorganisms. However, it may not be a permanent resident of the oral microbiota. The co-survival with oral microorganisms emphasizes the necessity for studying the role of the oral microbiota in the infectious and transmission cycle of H. pylori.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"79"},"PeriodicalIF":3.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11757641/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028036","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of molar incisor hypomineralization and demands for treatment according to the severity of its clinical manifestation.","authors":"Bianca Mattos Dos Santos Guerra, Roberta Costa Jorge, Patrícia Papoula Gorni Dos Reis, Gabriella de Freitas Machado, Tatiana Kelly da Silva Fidalgo, Vera Mendes Soviero","doi":"10.1007/s00784-024-06042-1","DOIUrl":"10.1007/s00784-024-06042-1","url":null,"abstract":"<p><strong>Aim: </strong>Assess the prevalence and severity of molar incisor hypomineralization (MIH) in children 6- to 12-year-old and correlate MIH severity with the complexity of treatment demands.</p><p><strong>Materials and methods: </strong>Between March and October 2023, 2,136 children were screened for MIH by two calibrated examiners. MIH severity was categorized in mild, moderate, severe, and very severe. Treatment requirements were categorized in basic, intermediate, and complex.</p><p><strong>Results: </strong>The prevalence of MIH was 15.5% (n = 331), 158 (47.7%) mild/moderate and 173 (52.3%) severe/very severe. Among the 126 children with atypical caries/restoration, cusp involvement was observed in 60.3%, endodontic treatment was necessary in 24.6%, only 15% needed restorations limited to two tooth surfaces with no cusp involvement. Extraction due to MIH was observed in 2.7%.</p><p><strong>Conclusion: </strong>The prevalence of MIH was in accordance with previous literature. Whenever a restorative treatment was necessary, it often involved multiple tooth surfaces and cusps. The complexity of treatment demands increased with age. It is necessary that oral health policymakers pay special attention to children with MIH to ensure appropriate treatment.</p><p><strong>Clinical relevance: </strong>MIH represents a challenge, especially severe cases with enamel post-eruptive breakdown and caries, requiring extensive restorations. MIH prevalence was assessed in a considerable large sample and the correlation between MIH severity and the complexity of treatment demands was analyzed. More than half of children exhibiting atypical caries/restorations required complex restorative treatment, involving multiple tooth surfaces and cusps. The manuscript prompts a reflection on the importance of evaluating whether the restoration will extend to cusp areas before determining the appropriate technique and material for treatment.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"82"},"PeriodicalIF":3.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Masquelet technique combined with concentrated growth factors for the reconstruction of rabbit mandibular marginal bone defect.","authors":"Lingling Chen, Tao Wang, Meifang Chen, Cheng Feng, Jianzhe Wang, Zhenyu Shi, Ye Wu","doi":"10.1007/s00784-025-06180-0","DOIUrl":"10.1007/s00784-025-06180-0","url":null,"abstract":"<p><strong>Objective: </strong>Both the Masquelet technique (MT) and concentrated growth factors (CGF) reduce early graft loss and improve bone regeneration. This study aims to explore the efficacy of combining MT with CGF for mandibular defect repair by characterizing the induced membrane and assessing in vivo osteogenesis.</p><p><strong>Materials and methods: </strong>Three experimental groups were compared: negative control (NC), MT, and Masquelet combined with CGF (MTC). Four weeks after the first surgery, histopathology is used to identify the morphological structure of the induced membrane, evaluate the degree of vascularization, and the secretion levels of osteogenesis and angiogenesis-related growth factors. In vivo osteogenesis was assessed with a second autologous bone graft surgery 4 weeks later, and bone reconstruction was evaluated by micro-CT and histopathology.</p><p><strong>Results: </strong>CGF significantly increased the induced membrane thickness, vascularization, and growth factor secretion levels. Quantitative micro-CT analysis showed that the bone volume fraction (BV/TV) at 4 weeks post-surgery was higher in the MTC group (23.30 ± 1.15%) compared to the MT group (16.50 ± 1.29%) and NC group (12.62 ± 1.23%) (P < 0.05). By 12 weeks, the difference in BV/TV between MTC (32.59 ± 0.11%) and MT (29.89 ± 0.49%) reduced, indicating consistent bone regeneration. Trabecular parameters were consistently higher in the MTC group, highlighting enhanced osteogenesis.</p><p><strong>Conclusion: </strong>Combining the Masquelet technique with CGF effectively reduces early bone graft absorption and promotes bone repair. These findings suggest potential benefits for oral and maxillofacial bone defect treatment, though further studies are needed to confirm long-term efficacy.</p><p><strong>Clinical relevance: </strong>Integrating Masquelet technique and CGF in mandibular reconstruction may improve clinical outcomes by enhancing bone regeneration and reducing graft failure.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"80"},"PeriodicalIF":3.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028113","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence of distal caries in second molar associated with impacted mandibular third molar and the position and level of impaction: a systematic review and meta-analysis.","authors":"Pablo Revuelta-Cortés, Jorge Cortés-Bretón Brinkmann, María Argandoña-Flores, Fabián Pérez-González, Santiago Bazal-Bonelli, Cristina Madrigal Martínez-Pereda, Cristina Meniz-García","doi":"10.1007/s00784-024-06131-1","DOIUrl":"10.1007/s00784-024-06131-1","url":null,"abstract":"<p><strong>Objectives: </strong>The primary objective of this systematic review was to analyze the overall prevalence of distal caries in mandibular second molars (MSMs) associated with the presence of impacted mandibular third molars (IMTMs). Secondary objectives were to determine how IMTM position and level of impaction influence the occurrence of distal caries.</p><p><strong>Materials and methods: </strong>PRISMA guidelines were followed. An automated search was conducted as well as a manual search for relevant clinical articles. The review included studies reporting IMTM and adjacent MSM presenting distal caries published in the last ten years. The quality of evidence was evaluated using the Newcastle-Ottawa Quality Assessment Scale.</p><p><strong>Results: </strong>Thirteen studies met the inclusion criteria and underwent analysis; they included a total of 13,788 patients. The overall prevalence of caries in MSMs adjacent to IMTMs was 29.89% (CI 95%: 21.05 - 38.74%; p < 0.001). Following Winter's classification, the mesioangular position was the most frequently associated with caries with 43.37% (CI 95%: 33.03 - 53.70%; p < 0.001). Following Pell & Gregory classification, position A was the most frequently associated with caries with 33.97% (CI 95%: 24.06 - 43.89%; p < 0.001).</p><p><strong>Conclusions: </strong>IMTMs in mesioangulated positions, especially if accompanied by level A impaction, present the highest risk of MSM distal caries.</p><p><strong>Clinical relevance: </strong>Knowing which positions and level of IMTMs are most frequently associated with distal caries in MSMs is crucial to implementing preventive measures.</p><p><strong>Review registration: </strong>This systematic review was registered in the International Prospective Register of Systematic Reviews (PROSPERO). Reg. number: CRD42023393143.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"83"},"PeriodicalIF":3.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of photobiomodulation on dentin hypersensitivity: a randomized controlled double-blind clinical trial.","authors":"María Victoria García Olazabal, Luis Eduardo Pascuali Moya, Rolf Wilhem Consolandich Cirisola, Laura Hermida Bruno, Federico Todeschini Safi, Ellen Sayuri Ando-Suguimoto, Priscila Larcher Longo, Cinthya Cosme Gutierrez Duran, Sandra Kalil Bussadori, Lara Jansiski Motta, Kristianne Porta Santos Fernandes, Raquel Agnelli Mesquita-Ferrari, Anna Carolina Ratto Tempestini Horliana","doi":"10.1007/s00784-025-06149-z","DOIUrl":"10.1007/s00784-025-06149-z","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate if photobiomodulation (PBM) can reduce dentin hypersensitivity (DH) through a randomized, controlled, double-blind clinical trial.</p><p><strong>Materials and methods: </strong>One hundred and twelve patients experiencing DH after non-surgical scaling and root planing (SRP) were enrolled and divided into the Experimental Group - SRP + PBM (660 nm, 1.061 J/cm²) and the Control Group - SRP + PBM simulation. The primary outcome was the assessment of DH through tactile and thermal stimulation using the visual analog scale (VAS) after seven days. Additionally, paracetamol was prescribed and quantified as needed. Also, the impact of oral health on participants' quality of life using the Oral Health Impact Profile (OHIP-14) questionnaire was applied. Outcome assessments occurred seven days and one-month post-application.</p><p><strong>Results: </strong>In both 7 and 30 days, pain values were significantly lower in the experimental group compared to the control group (P = 0.001 and < 0.001, respectively). No differences were observed between the groups regarding analgesic usage. The experimental group also showed a significant improvement in the impact of oral health on participants' quality of life (P < 0.001), with lower OHIP-14 scores at all time points (P = 0.008).</p><p><strong>Conclusions: </strong>These results suggest that photobiomodulation significantly reduces pain at 7- and 30-days following scaling and root planing. Additionally, it is associated with improvements in the oral health-related quality of life in patients with dentin hypersensitivity.</p><p><strong>Clinical trial registration: </strong>NCT05946265.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"84"},"PeriodicalIF":3.1,"publicationDate":"2025-01-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143032470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adjunctive therapea - a promising method in the treatment of periodontal disease.","authors":"Viktoria Margaryan, Eduard Aghasyan, Lazar Yessayan, Hakob Khachatryan, Curd Bollen, Gagik Hakobyan","doi":"10.1007/s00784-025-06163-1","DOIUrl":"10.1007/s00784-025-06163-1","url":null,"abstract":"<p><strong>Objectives: </strong>The aim of the study is to compare the clinical efficacy of the application of \"Armenicum\" paste as an adjunct to SRP for the non-surgical treatment of patients with periodontitis.</p><p><strong>Methods: </strong>The current RCT prospective study was conducted on 157 patients with chronic periodontitis. The patients were blind randomly assigned into two groups: Group A (SRP + Armenicum\" paste) 81 patients (42 males and 39 females, 37 to 68 years) and Group B (SRP) 76 patients (39 males and 37 females, 37 to 68 years). Periodontal indices BOP, PPD, and DPI within each treatment group were measured before periodontal therapy, 3 and 6 months after the treatment. Group A underwent a periodontal treatment which included: supragingival and subgingival scaling, and additional use of local \"Armenicum\" paste. The Group B group only received supragingival and subgingival scaling.</p><p><strong>Results: </strong>In our study, the mean BOP, DPI, and PPD showed a statistically significant difference from baseline to 3 months and 6 months (p ≤ 0.05) in both Group A and Group B. But, mean BOP and mean PPD reduction gain was found to be greater in Group-A than Group B at 3 months and 6 months. No statistical differences in clinical indices were recorded depending on gender and age.</p><p><strong>Conclusion: </strong>These results indicate that topical \"Armenicum\" paste provides an effective adjunctive treatment of chronic periodontitis.</p><p><strong>Clinical relevance: </strong>The results of the current study showed that the adjunctive use of \"Armenicum\" reduced signs of inflammation compared to standard SRP treatment alone. Periodontal therapy using Armenicum paste application can be considered as a promising method in the treatment of periodontitis.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"78"},"PeriodicalIF":3.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143028032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Salivary proteomic analysis in patients with type 2 diabetes mellitus and periodontitis.","authors":"Monique Vieira Furukawa, Marissol Fernandes Oliveira, Rodrigo Augusto da Silva, Priscila Macedo Máximo, Aline Dionizio, Talita Mendes Oliveira Ventura, Sheila Cavalca Cortelli, José Roberto Corelli, Marília Afonso Rabelo Buzalaf, Emanuel Silva Rovai","doi":"10.1007/s00784-025-06171-1","DOIUrl":"10.1007/s00784-025-06171-1","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to compare the salivary protein profile in individuals with Type 2 Diabetes Mellitus (DM2) and periodontitis and their respective controls.</p><p><strong>Methods: </strong>Eighty participants were included in the study. The four groups were formed by individuals with DM2 and periodontitis (DM2 + P, n = 20), DM2 without periodontitis (DM2, n = 20), periodontitis without DM2 (P, n = 20) and individuals without periodontitis and without DM2 (H, n = 20). Periodontal clinical examinations were performed and unstimulated saliva was collected. Proteomic analysis was performed by shotgun mass spectrometry. The results were obtained by searching the Homo sapiens database of the UniProt catalog.</p><p><strong>Results: </strong>A total of 220 proteins were identified in saliva samples. In the comparison between DM2 + P and DM2 groups, 27 proteins were up-regulated [e.g. S100-A8 was 6 times up-regulated (humoral immune response pathway)]. The DM2 + P and P groups had 26 up-regulated proteins [e.g. Immunoglobulin lambda constant 7 more than 2 times up-regulated (complement activation pathway)]. The non-DM2 groups (P and H) presented 22 up-regulated proteins [e.g. Glyceraldehyde-3-phosphate dehydrogenase more than 2 times up-regulated (Peptidyl-cysteine S-nitrosylation pathway)]. The groups without periodontitis (DM2 and H) showed 23 were up-regulated proteins [e.g. Hemoglobin subunit alpha that was more than 10 times up-regulated (cellular oxidant detoxification pathway)].</p><p><strong>Conclusion: </strong>The presence of DM2 and periodontitis significantly impacts the salivary proteome. Our proteomic analysis demonstrated that changes in the S100 family proteins (S100A8 and S100 A9) are highly related to the presence of DM2 and periodontitis.</p><p><strong>Clinical relevance: </strong>Diabetes Mellitus (DM) and periodontitis are highly prevalent chronic diseases that present a wide variety of signs and symptoms. They present a bidirectional relationship, where patients with DM have a higher prevalence and severity of periodontitis, and patients with periodontitis have a higher prevalence of DM, worse glycemic control, and more diabetic complications. Diagnosing periodontitis requires specific clinical examinations, which require a highly trained operator. In this study, we used high throughput proteomics in order to evaluate non-invasive biomarkers for periodontitis in type 2 DM subjects. The results can contribute to earlier, more accurate, and less costly diagnosis of periodontitis in diabetic subjects, enabling better diabetes control.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"77"},"PeriodicalIF":3.1,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143022473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Upper airway changes after orthognathic surgery in patients with skeletal class III high-angle malocclusion and mandibular deviation.","authors":"Dong-Lan Mei, Li-Nan Liu, Li-Chi Han","doi":"10.1007/s00784-024-06105-3","DOIUrl":"10.1007/s00784-024-06105-3","url":null,"abstract":"<p><strong>Objectives: </strong>This study analyzed the differences in the upper airway of patients with skeletal Class III high-angle malocclusion with and without mandibular deviation, and further investigated whether there are differences in the changes in upper airway space after orthognathic surgery between the two groups.</p><p><strong>Materials and methods: </strong>15 patients with skeletal Class III high-angle malocclusion and mandibular deviation, and 15 patients without mandibular deviation were selected to explore the impact of mandibular deviation on the upper airway. Additionally, 16 patients with mandibular deviation undergoing orthodontic-orthognathic combined treatment, and 13 patients without mandibular deviation, were selected to investigate the differences in the changes in upper airway space after orthognathic surgery between the two groups.</p><p><strong>Results: </strong>In patients with skeletal Class III high-angle malocclusion, the deviation group showed significantly smaller sagittal diameter/maximum transverse diameter, cross-sectional area, volumes of oropharynx and hypopharynx, and total volume compared to the normal group, with all differences being statistically significant. After orthognathic surgery, the postoperative sagittal diameter/maximum transverse diameter of the oropharyngeal airway increased in the deviation group, while it decreased in the normal group. The postoperative reductions in cross-sectional area, volumes, and total volume of the oropharynx and hypopharynx were more pronounced in the normal group.</p><p><strong>Conclusion: </strong>In patients with skeletal Class III high-angle malocclusion, mandibular deviation results in narrowing of the lower portion of the upper airway. The orthognathic surgical correction of mandibular deviation compensates to some extent for the reduction in the cross-sectional area and volume of the upper airway caused by the surgery itself.</p><p><strong>Clinical relevance: </strong>For patients with skeletal Class III high-angle malocclusion with mandibular deviation, a thorough assessment of the upper airway should precede the selection of orthognathic surgery procedures. For patients with normal preoperative upper airway morphology, consideration may prioritize correction of facial aesthetics and occlusion. For patients with pre-existing narrow upper airways, as mandibular setback exacerbates narrowing and the compensatory effect of mandibular deviation correction on the airway is limited, it is suggested that these patients prioritize bimaxillary surgery or reduce the amount of mandibular setback to better promote postoperative respiratory function health.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 1","pages":"73"},"PeriodicalIF":3.1,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001321","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}