{"title":"Trends in accident-related traumatic dental injuries among children: a 10-year retrospective study of patients attending a university clinic.","authors":"Anika Islam, Spyridon N Papageorgiou, Blend Hamza","doi":"10.1007/s00784-025-06546-4","DOIUrl":"10.1007/s00784-025-06546-4","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze accident-related traumatic dental injury (TDI) data to determine the occurrence, characteristics, and types of dental injuries in primary and permanent dentitions of underage patients attending a university clinic.</p><p><strong>Materials and methods: </strong>A retrospective observational study was conducted at the Clinic of Orthodontics and Pediatric Dentistry of Zurich from 2010 to 2019 and involved children with accident-related TDIs from the ages of 0 to 18 years old. Data regarding patient- and trauma-related characteristics were extracted and analyzed statistically according to dentition, tooth, age, sex, and time elapsed before visiting the dentist at 5%.</p><p><strong>Results: </strong>The sample included 1,291 TDIs seen in a sample predominantly comprised of boys (59.8%), with a median age of 3.0 years (interquartile range 1.8-7.1 years), mostly in the deciduous dentition (71.6%) with ≥ 1 TDIs between 2010 and 2019. Accidents mainly occurred at home (45.6%) or outdoors (30.3%) and were primarily the result of falls (37.2%) or playtime (29.5%). Affected children often visited the dentist within the first 24 h (77.1%). Deciduous teeth (51.9%) and permanent teeth (37.2%; p = 0.001) primarily exhibited injuries to the periodontal tissue.</p><p><strong>Conclusion: </strong>This study found boys were more prone to TDI than girls. Significant differences were seen in the injury mechanisms between deciduous and permanent teeth. Moreover, injuries to the periodontal tissue, with or without tooth fractures, were the most common trauma found.</p><p><strong>Clinical relevance: </strong>Gaining insights into TDI patterns over time can help clinical practitioners develop more effective prevention measures.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"450"},"PeriodicalIF":3.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433922/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Danilo Cassiano Ferraz, Jáder Camilo Pinto, Ariadne Letra, Renato Menezes Silva, Letícia Chaves de Souza, Juliane Maria Guerreiro-Tanomaru, Mario Tanomaru-Filho
{"title":"Physicochemical properties and periodontal ligament stem cell response to NeoMTA 2.","authors":"Danilo Cassiano Ferraz, Jáder Camilo Pinto, Ariadne Letra, Renato Menezes Silva, Letícia Chaves de Souza, Juliane Maria Guerreiro-Tanomaru, Mario Tanomaru-Filho","doi":"10.1007/s00784-025-06538-4","DOIUrl":"10.1007/s00784-025-06538-4","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the physicochemical properties and cellular response of NeoMTA 2 as an endodontic sealer (NMTA2S) and root repair material (NMTA2R) compared to BioRoot RCS (BIR) and MTA Repair HP (MTAHP).</p><p><strong>Materials and methods: </strong>Setting time, flow, radiopacity, and solubility were evaluated based on ISO 6876/2012 standards. Volumetric change was measured using micro-computed tomography. Periodontal ligament stem cells (PDLSCs) were used for cell viability and messenger RNA expression assays.</p><p><strong>Results: </strong>NMTA2S had longer setting time than BIR (p < .05), while NMTA2R set longer than MTAHP (p < .05). All materials met ISO 6876 standards for radiopacity and flow, with similar solubility between NMTA2S and BIR, or NMTA2R and MTAHP (p > .05). NMTA2S decreased in volume, while BIR increased (p < .05). Volume changes were similar among root repair materials and immersion media (p > .05). All materials supported PDLSC viability. TNF was upregulated only in NMTA2S with the 6-hour eluate. COL1A1 and SPP1 were upregulated in all groups exposed to the 6-hour eluate. With the 24-hour eluate, only BIR sustained COL1A1 signaling, and did not significantly express SPP1. With the 48-hour eluate, COL1A1 was upregulated in all groups along with ALPL.</p><p><strong>Conclusion: </strong>Despite their longer setting times, NMTA2S and NMTA2R exhibited acceptable physicochemical and biological properties. Additionally, NMTA2S and NMTA2R appear to offer distinct advantages towards an osteogenic potential, which provides valuable insights for endodontic or reparative treatment choices.</p><p><strong>Clinical relevance: </strong>This study provides the first evidence of osteogenic gene expression in PDLSCs by NeoMTA 2, as an endodontic sealer and root repair material. The findings highlight NeoMTA 2's distinct biological response at different eluate time points, reinforcing its potential for endodontic and reparative applications.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"449"},"PeriodicalIF":3.1,"publicationDate":"2025-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Rongyin Sun, Yang Zhou, Qiyuan Pan, Ruolin Wang, Yifan Guo, Yaru Huo, Yanrou Zhao, Min Liu
{"title":"Changes and health inequalities in the global burden of periodontal diseases from 1990 to 2021: A population-based study.","authors":"Rongyin Sun, Yang Zhou, Qiyuan Pan, Ruolin Wang, Yifan Guo, Yaru Huo, Yanrou Zhao, Min Liu","doi":"10.1007/s00784-025-06558-0","DOIUrl":"https://doi.org/10.1007/s00784-025-06558-0","url":null,"abstract":"","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"447"},"PeriodicalIF":3.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032803","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Hisham Mahmoud Hamdy Abada, Mohamed Abd El Rahman El Shreif, Faten Mohamed Ahmed Ghonimy, Ebtesam Osama Abo El-Mal, Dana Saeed Abd Elmonem El Gemaie
{"title":"The effect of different obturation techniques on post-obturation pain and sealer extrusion in single-visit root canal treatment: a prospective clinical randomized study.","authors":"Hisham Mahmoud Hamdy Abada, Mohamed Abd El Rahman El Shreif, Faten Mohamed Ahmed Ghonimy, Ebtesam Osama Abo El-Mal, Dana Saeed Abd Elmonem El Gemaie","doi":"10.1007/s00784-025-06487-y","DOIUrl":"10.1007/s00784-025-06487-y","url":null,"abstract":"<p><strong>Objectives: </strong>Postoperative pain remains a significant concern in endodontics. The main aim of this clinical trial was to assess the impact of various obturation technique and sealer types on post-obturation pain and sealer extrusion in single-visit nonsurgical root canal treatments.</p><p><strong>Materials and methods: </strong>Study participants were recruited through consecutive sampling from patients referred to the Endodontic Department, Faculty of Dentistry, Institution University, diagnosed as asymptomatic irreversible pulpitis. The study was conducted on 150 cases that were equally and randomly allocated to each of the studied groups (30 for each group) as following; Group 1 - cold lateral compaction with CeraSeal (CLC-CS); Group 2 - continuous wave compaction with CeraSeal (CWC-CS); Group 3 - single cone technique with CeraSeal (SC-CS); Group 4 - Cold lateral compaction with AH Plus (CLC-AH); and Group 5 - continuous wave compaction with AH Plus (CWC-AH). All endodontic procedures were performed by a single experienced endodontist to standardize treatment protocols. The main outcomes were the post-obturation pain which was assessed using a visual analog scale (VAS) scale (0-10), and the incidence of sealer extrusion among the studied groups.</p><p><strong>Results: </strong>At 6, 24, and 72 h the postobturation pain score did not differ significantly between all studied groups. After 12 and 48 h CWC-CS and CLC-CS showed the lowest significant postobturation pain score respectively, and CWC-AH had the most significant postobturation pain score. During the study, none of the patients needed an emergency visit, the pain score was ranged from (0:1.4). Within the same group, the pain intensity began to significantly decrease for gp1 (CLC-CS) after 24 h, for gp3, gp4, and gp5 (SC-CS, CLC-AH, and CWC-AH, respectively) after 12 h, and for gp2 (CWC-CS) after 6 h. After 72 h, the level of pain in each group was around 0. Regardless of the type of sealer used, no significant difference was found between the type of obturation technique and the postoperative pain intensity (p = 0.124), while regardless of the type of obturation technique used, there was a significant difference in postoperative pain intensity and sealer type (p < 0.001). The incidence of sealer extrusion did not differ significantly between the tested groups (p = 0.499), the results showed that the presence of sealer extrusion was associated with higher significant pain score (p < 0.001).</p><p><strong>Conclusion: </strong>The postoperative pain score after Single-Visit RCT for patient diagnosed as asymptomatic irreversible pulpitis was low to moderate pain score, presence of sealer extrusion increased the postoperative pain intensity. Regardless the type of sealer, different obturation techniques did not associated with postoperative pain intensity, while regardless the obturation technique, AH Plus sealer was associated with higher postoperative pain intensity tha","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"445"},"PeriodicalIF":3.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12422989/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032854","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ying Man, Chun Fan, Huijuan Qu, Chenxia Wang, Shuangshuang Li, Guizhen Cao
{"title":"Progesterone-induced activation of progesterone receptor alleviates alveolar bone resorption and inflammatory response in periodontitis.","authors":"Ying Man, Chun Fan, Huijuan Qu, Chenxia Wang, Shuangshuang Li, Guizhen Cao","doi":"10.1007/s00784-025-06473-4","DOIUrl":"https://doi.org/10.1007/s00784-025-06473-4","url":null,"abstract":"<p><strong>Objective: </strong>Progesterone (PG) and its target, progesterone receptor (PGR), are important regulators in inflammatory diseases. This study aimed to investigate the specific role of PG in periodontitis and to elucidate the underlying mechanisms involving PGR.</p><p><strong>Methods: </strong>Women with periodontitis, including 250 with PG deficiency, 250 with PG supplementation, and 245 controls (normal PG) were enrolled. The distance between the cemento-enamel junction to the alveolar bone crest (CEJ-ABC) and bone mineral density (BMD) were measured by cone beam computed tomography, and the levels of IL-6 and TNF-α in gingival crevicular fluid were measured by ELISA. In vitro, primary human periodontal mesenchymal stem cells (hPDLSCs) were isolated and treated with LPS in combination with PG and/or RU486 (a PGR antagonist). Osteogenic differentiation was assessed by immunofluorescence of Runx2, OCN, and ALP, and by Alizarin red staining. The inflammatory response was assessed by ELISA of IL-6 and TNF-α. Western blot was performed to evaluate the changes in the ERK/JNK/p38-MAPK signalling pathway.</p><p><strong>Results: </strong>Significantly higher CEJ-ABC and lower BMD were found in some teeth in the PG deficiency group than in the control and PG supplementation groups. The GCF levels of IL-6 and TNF-α were also significantly higher in the PG deficiency group. At the cellular level, PGR was up-regulated by PG in LPS-treated hPDLSCs. PG inhibits the effects of LPS on inducing inflammatory response (IL-6 and TNF-α) and inhibiting osteogenic differentiation (Runx2, OCN, ALP, and mineralised nodules) in hPDLSCs, but RU864 reversed the above effects of PG. Additionally, PG-induced activation of PGR inhibited the ERK/JNK/p38-MAPK signalling pathway in LPS-treated hPDLSCs.</p><p><strong>Conclusions: </strong>In women with periodontitis, the alveolar bone resorption and inflammation were more pronounced with PG deficiency. In vitro, PG-induced activation of PGR signalling inhibited inflammation and promoted osteogenesis in hPDLSCs. PG supplementation may be a potential strategy to alleviate periodontitis.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"446"},"PeriodicalIF":3.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032846","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nimet Gül Görgülü, Hatice Selin Güngörmek, Yaprak Kalkan, Başak Doğan
{"title":"Evaluation of chemerin, fetuin-A, interleukin-34, and interleukin-13 levels following periodontal treatment in diabetes mellitus.","authors":"Nimet Gül Görgülü, Hatice Selin Güngörmek, Yaprak Kalkan, Başak Doğan","doi":"10.1007/s00784-025-06539-3","DOIUrl":"10.1007/s00784-025-06539-3","url":null,"abstract":"<p><strong>Objective: </strong>This cohort study investigated salivary and serum chemerin, fetuin-A, interleukin (IL)-34, and IL-13 changes in type 2 diabetes mellitus (T2DM) periodontitis following non-surgical periodontal therapy (NSPT).</p><p><strong>Materials and methods: </strong>A total of 110 participants were assigned to five groups (n = 22 each): non-periodontitis, non-periodontitis with T2DM, periodontitis (P), well-controlled T2DM periodontitis (WDM-P), and poorly controlled T2DM periodontitis (PDM-P). Periodontal parameters were recorded and biological samples collected at baseline and/or 3 months post-NSPT. Biomolecule levels were measured using ELISA.</p><p><strong>Results: </strong>All periodontitis groups improved in periodontal parameters after 3 months (p < 0.05), but the proportion of patients who responded poorly to NSPT was higher in the PDM-P group compared to the P group (p = 0.026). HbA1c decreased in WDM-P and PDM-P groups at 3 months (p < 0.05). All salivary biomolecules were individually associated with periodontitis (p < 0.05), and their combined model distinguished periodontitis (AUC: 0.94). Serum chemerin and fetuin-A were linked to T2DM (p < 0.05), and their combination predicted T2DM (AUC: 0.91). After NSPT, salivary fetuin-A increased, salivary IL-13 decreased in three periodontitis groups (p < 0.05), whereas salivary chemerin, IL-34, and serum IL-34 reduced only in P group (p < 0.05).</p><p><strong>Conclusion: </strong>Salivary fetuin-A and IL-13 appear involved in periodontitis pathogenesis, while serum chemerin and fetuin-A in the T2DM. T2DM may hinder inflammation resolution, particularly involving chemerin and IL-34.</p><p><strong>Clinical relevance: </strong>The distinct biomolecule changes in systemically healthy versus T2DM periodontitis patients suggests that T2DM may impair inflammation resolution, underscoring the importance of personalized periodontal treatment strategies. This study was retrospectively registered on ClinicalTrials.gov (NCT06135532) on November 11, 2023.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"448"},"PeriodicalIF":3.1,"publicationDate":"2025-09-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145032754","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Michele Paolantonio, Paolo De Ninis, Pasquale Santamaria, Giuseppe Balice, Matteo Serroni, Bruna Sinjari, Alessio Frisone, Stefania Di Gregorio, Luigi Romano, Giovanna Murmura, Beatrice Femminella
{"title":"Clinical comparison of two surgical techniques in obtaining complete root coverage of single RT1 gingival recessions.","authors":"Michele Paolantonio, Paolo De Ninis, Pasquale Santamaria, Giuseppe Balice, Matteo Serroni, Bruna Sinjari, Alessio Frisone, Stefania Di Gregorio, Luigi Romano, Giovanna Murmura, Beatrice Femminella","doi":"10.1007/s00784-025-06491-2","DOIUrl":"10.1007/s00784-025-06491-2","url":null,"abstract":"<p><strong>Objectives: </strong>This study aimed to compare the efficacy of the full-thickness palatal graft technique (FTPGT) and the coronally advanced flap with subepithelial connective tissue graft (CAF + SCTG) in achieving complete root coverage (CRC) in single gingival recessions (GR).</p><p><strong>Methods: </strong>Forty healthy patients with a single RT1 GR were randomized into two groups: 20 treated with CAF + SCTG and 20 with FTPGT. Baseline and 12-month measurements of GR, keratinized tissue width (KTW), probing depth (PD), clinical attachment level (CAL), and gingival thickness (GT) were recorded. CRC percentage, root coverage percentage (RC%), Root Coverage Esthetic Score (RES), patient-reported outcomes (PROs), and palatal wound healing were evaluated.</p><p><strong>Results: </strong>At the 12-month evaluation, 19 patients in the FTPGT group achieved CRC compared to 12 in the CAF + SCTG group (p < 0.004). FTPGT showed significantly more GR reduction (0.7 mm ± 0.19), greater CAL gain (0.65 mm ± 0.20), increased GT (0.99 mm ± 0.27), p < 0.001, and KTW gain (2.95 mm ± 0.5), and a higher RC% (12.71 ± 3.82), p < 0.002. PROs did not significantly differ between treatments, nor did palatal healing parameters. CAF + SCTG showed superior RES scores compared to FTPGT (p < 0.0003).</p><p><strong>Conclusions: </strong>FTPGT is more effective than CAF + SCTG in achieving CRC and improving GT, KTW, CAL gain, and GR reduction, particularly in deep recessions. CAF + SCTG provides superior esthetic outcomes. PROs were comparable between the two techniques, but palatal healing was slower in the FTPGT group.</p><p><strong>Clinical relevance: </strong>FTPGT, especially in deep single recessions, could serve as an alternative to CAF + SCTG, as it is associated with greater CRC, greater GT and KTW. However, it is linked to slower healing of the palatal donor site. Clincaltrial.gov registration NCT04028037.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"444"},"PeriodicalIF":3.1,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029144","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Letter to the editor: Trends in incidence of untreated caries in permanent teeth in BRICS countries: an age-period-cohort analysis from 1992 to 2021 and projections for the next two decades.","authors":"Qixing Xia, Yanting Jiang, Yongwu Wang","doi":"10.1007/s00784-025-06532-w","DOIUrl":"https://doi.org/10.1007/s00784-025-06532-w","url":null,"abstract":"","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"443"},"PeriodicalIF":3.1,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Long Zhu, Si Liang, Yang Yang, Ziqi Su, Lijia Ou, Weimeng Zhang, Binjie Liu, Ousheng Liu, Hui Feng
{"title":"Association between vitamin K intake and periodontitis in American elderly population: a cross-sectional analysis of NHANES data.","authors":"Long Zhu, Si Liang, Yang Yang, Ziqi Su, Lijia Ou, Weimeng Zhang, Binjie Liu, Ousheng Liu, Hui Feng","doi":"10.1007/s00784-025-06527-7","DOIUrl":"10.1007/s00784-025-06527-7","url":null,"abstract":"<p><strong>Background: </strong>An increasing amount of data has been acquired on the close relationship between Vitamin K intake and the progression of periodontitis. The purpose of this study was to estimate whether Vitamin K intake is associated with periodontitis among older adults in America using information from the National Health and Nutrition Examination Survey (NHANES) database.</p><p><strong>Methods: </strong>A cross-sectional analysis of data on periodontal indices and vitamin K intake among American adults aged 60 years and older in the 2009-2014 NHANES database was extracted. Periodontitis was defined according to CDC/AAP criteria, classification of periodontitis and severity of periodontitis according to the degree and amount of attachment loss in the interproximal site, and vitamin K intake was categorized using optimal cutoff value. Univariate and multivariate logistic regression analyses were used to investigate the association between vitamin K intake and the risk of periodontitis.</p><p><strong>Results: </strong>Based on the information analysis of 2303 participants who met the inclusion criteria, the risk of periodontitis was lower in the elderly population with higher vitamin K intake. Especially, a statistically significant reduction in the prevalence of periodontitis was observed in elderly populations with vitamin K intake greater than 89.51 mg/d (OR = 0.648,95%Cl = 0.502-0.837, P value = 0.001) compared to those with vitamin K intake less than 89.51 mg/d. Subgroup analyses revealed that this association was more prominent in elderly people aged 60-69 years and 70-79 years, the female/male population, the Non-Hispanic White population, those with a poverty index of 1.3-3.5, education level over high school grad/GED, non-smokers, 1-5 drinks/month, non-alcohol drinkers, overweight, normal blood pressure and without diabetes.</p><p><strong>Conclusion: </strong>Our research found a strong relationship between vitamin K intake and periodontitis among elderly people in the United States, suggesting vitamin K intake is a possible risk factor and may be a novel idea for the diagnosis and treatment of periodontitis.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"442"},"PeriodicalIF":3.1,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417290/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145022936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Teena Selvaraj, Jaideep Mahendra, Nikita Ravi, Pavithra H Dave, Muskan Bedi, Sivaraj Moti Ram Rao, Pradeep K Yadalam, Carlos M Ardila
{"title":"Estimation of salivary protectin D1 in periodontitis patients with metabolic syndrome following non-surgical periodontal therapy.","authors":"Teena Selvaraj, Jaideep Mahendra, Nikita Ravi, Pavithra H Dave, Muskan Bedi, Sivaraj Moti Ram Rao, Pradeep K Yadalam, Carlos M Ardila","doi":"10.1007/s00784-025-06514-y","DOIUrl":"10.1007/s00784-025-06514-y","url":null,"abstract":"<p><strong>Objectives: </strong>This study aims to assess periodontal and biochemical parameters and evaluate the salivary Protectin D1 levels in periodontitis patients with and without metabolic syndrome after non-surgical periodontal therapy.</p><p><strong>Materials and methods: </strong>Forty patients were categorized into two groups: 20 patients in Group P (systemically healthy patients with stage II/III grade B periodontitis) and 20 patients in Group P+MS (patients with stage II/III grade B periodontitis and metabolic syndrome). Parameters including age, gender, height, weight, body mass index, waist circumference, socio-economic status, oral hygiene index (OHI), modified gingival index (MGI), probing pocket depth, clinical attachment levels, fasting blood glucose, HDL-c, total triglycerides, and blood pressure were recorded. Saliva samples were collected before scaling and root planing (PMPR). Full-mouth subgingival instrumentation (SGI) was performed on day 10, followed by reassessment on day 30.</p><p><strong>Result: </strong>Demographic and baseline periodontal parameters were significantly higher in the P+MS group compared to the P group (p < 0.001). Both groups showed significant improvement in periodontal parameters after PMPR and SGI by the 30th day (p < 0.01). Salivary Protectin D1 levels increased significantly in both groups after treatment (p < 0.01), although no significant difference was observed between the groups at baseline and the 30th day. Protectin D1 levels positively correlated with HDL-c, blood pressure, and MGI at baseline, and with OHI, MGI, PPD, and CAL on the 30th day, but showed no significant association with periodontal parameters.</p><p><strong>Conclusion: </strong>Periodontitis patients with metabolic syndrome exhibited worse baseline periodontal and biochemical profiles than periodontitis-only patients. Non-surgical periodontal therapy significantly improved periodontal health in both groups, with a concurrent increase in salivary PD1 levels, though no intergroup difference in PD1 expression was observed. While PD1 correlated with HDL-c, blood pressure, and periodontal indices, it did not differentiate the therapeutic response between groups, suggesting PD1 may reflect general resolution of inflammation rather than MS-specific pathways. Further research is needed to elucidate the role of PD1 in periodontitis with comorbid metabolic syndrome.</p><p><strong>Clinical relevance: </strong>Protectin D1 holds promise as a biomarker for the effective management of periodontitis and metabolic syndrome, potentially aiding in both diagnosis and treatment strategies.</p>","PeriodicalId":10461,"journal":{"name":"Clinical Oral Investigations","volume":"29 10","pages":"441"},"PeriodicalIF":3.1,"publicationDate":"2025-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12414852/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145014024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}