Clinical Oral Implants Research最新文献

{"title":"Comprehensive Update on Implants in Patients With Head and Neck Cancer (2021–2024): Systematic Review and Meta-Analysis of the Impact of Radiotherapy and Chemotherapy on Implant Survival","authors":"Shengchi Fan,&nbsp;Leonardo Diaz,&nbsp;Gustavo Sáenz-Ravello,&nbsp;Eduard Valmaseda-Castellon,&nbsp;Bilal Al-Nawas,&nbsp;Eik Schiegnitz","doi":"10.1111/clr.14450","DOIUrl":"10.1111/clr.14450","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to investigate implant outcomes in patients with head and neck cancer undergoing radiotherapy or chemotherapy by incorporating the latest research findings.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>The present review was conducted to update the focused question: What is the survival rate of implants placed in patients with head and neck cancer receiving radiotherapy or chemotherapy compared to non-irradiated patients? It built upon two previous systematic reviews (2014 and 2022) and provided an updated synthesis of the literature, focusing on clinical studies published between 2021 and 2024. The earlier reviews were included in the quantitative synthesis only to offer a broader longitudinal perspective.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nine studies were identified, with seven included in the quantitative synthesis and meta-analysis. The implant survival rate was significantly lower in irradiated patients (85.6%) compared to non-irradiated patients (90.0%) (RR = 1.62, 95% CI: 1.33–1.98, <i>p</i> &lt; 0.0001, <i>I</i>² = 0.2%). Additionally, implant failure risk was higher in grafted bone (RR = 2.03, 95% CI: 1.39–2.96, <i>p</i> = 0.0018, <i>I</i>² = 21.9%) than in native bone. Among irradiated patients, those receiving radiochemotherapy exhibited an even greater risk of implant failure (RR = 1.97, 95% CI: 1.09–3.56, <i>p</i> = 0.0331, <i>I</i>² = 0%) compared to non-irradiated patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Current evidence indicates that radiotherapy/chemotherapy significantly increases the risk of implant loss in patients with head and neck cancer, with higher radiation doses possibly being associated with increased peri-implant bone loss, while implants placed in native bone exhibit a lower risk of failure compared to those placed in grafted bone.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 9","pages":"1035-1052"},"PeriodicalIF":5.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14450","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medication-Related Osteonecrosis of the Jaws in Patients on Antiresorptive Medication With Dental Implants. A Scoping Review","authors":"Sanne Werner Moeller Andersen,&nbsp;Nishma Vandvig Hindocha,&nbsp;Iben Poulsen,&nbsp;Henning Schliephake,&nbsp;Simon Storgård Jensen","doi":"10.1111/clr.14453","DOIUrl":"10.1111/clr.14453","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Patients receiving antiresorptive medication (AR) for osteoporosis or cancer are at risk of medication-related osteonecrosis of the jaws (MRONJ), especially after surgical procedures. Dental implant (DI) placement in high-dose AR (HDAR) patients is widely discouraged, and thorough counseling is recommended for low-dose AR (LDAR) patients. However, data on the role of AR type, dose, and duration remain limited. This review evaluates MRONJ associated with DIs, focusing on AR type and accumulated dose, and identifies local and systemic risk factors.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This review follows the PCC framework for PRISMA-ScR, comparing patients on AR who developed DI-related MRONJ to those who did not, based on the available clinical evidence. A systematic search was conducted on April 13, 2024, in PubMed, Embase, and Cochrane Library. Two reviewers independently screened and extracted data; a third reviewer resolved disagreements. Data extraction included demographics, primary disease, AR type, dose, treatment duration, DI location, and MRONJ details.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of 2201 articles, 28 studies were included involving 76 patients with 215 DI (154 in LDAR, 61 in HDAR). The development of MRONJ was reported in 15 studies involving LDAR and four studies on HDAR.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Evidence was insufficient to confirm an association between accumulated AR dose and MRONJ associated with DIs. No specific risk factors were identified, emphasizing the need for standardized reporting on AR type, dosage, treatment duration, and intervals to facilitate comprehensive risk assessment. Until evidence-based guidelines emerge, DI therapy in HDAR or long-term LDAR patients should be limited to specialized centers.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 10","pages":"1173-1201"},"PeriodicalIF":5.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14453","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Air Powder Water-Jet Devices in Cleaning Implant Surfaces in a Non-Surgical Peri-Implantitis Treatment Simulation—A Laboratory Study","authors":"Kristina Bertl,&nbsp;Alexandra Isik,&nbsp;Tai Truong,&nbsp;Loukia M. Spineli,&nbsp;Patrick Heimel,&nbsp;Wolfgang Manschiebel,&nbsp;Andreas Stavropoulos","doi":"10.1111/clr.14452","DOIUrl":"10.1111/clr.14452","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the impact of implant surface and instrumentation time on the efficacy of two air powder water-jet (APWJ) devices in cleaning the implant surface in a simulation of non-surgical peri-implantitis treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Turned and modified surface implants (28 each) were coated with a biofilm imitation and mounted on resin models replicating peri-implant intra-osseous defects, including a soft tissue replica. The entire implant periphery was instrumented for 5 or 15s per implant sextant (i.e., in total 30 or 90s per implant), with one of two different APWJ devices using either a glycine or an erythritol powder. Residual biofilm imitation was automatically assessed on standardized photographs and expressed as percentage of the exposed implant surface.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Implant surface (<i>ε</i>²:0.253, <i>p</i> &lt; 0.001) and instrumentation time (<i>ε</i>²:0.044, <i>p</i> = 0.036) had a moderate and small effect, respectively, on the outcome, that is, instrumenting turned compared to modified surface implants as well as using a longer compared to a shorter instrumentation time resulted in less residual biofilm imitation. Complete biofilm imitation removal was achieved only in four turned implants, treated for 15s per sextant. Every second turned implant presented with a maximum of 5% residual biofilm imitation, while only two modified implants achieved this level of cleanliness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>In a non-surgical peri-implantitis treatment simulation with APWJ devices, superior biofilm imitation removal was achieved at turned implants, and a longer instrumentation time resulted in less residual biofilm imitation. Modified implants had high chances of incomplete biofilm imitation removal, especially at the apical part of the defect. Complete biofilm imitation removal was in general largely unpredictable.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 9","pages":"1075-1085"},"PeriodicalIF":5.3,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14452","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144319325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Irrigation, Bur Size and Rotational Speed on Thermographic Heat at Implant Site Osteotomy Interface. An In Vitro Study","authors":"Karl Paeßens,&nbsp;Leonard van Bebber,&nbsp;Holger Zipprich,&nbsp;Paul Weigl","doi":"10.1111/clr.14462","DOIUrl":"10.1111/clr.14462","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to evaluate the impact of drill diameter, rotational speed, and irrigation on critical heat generation (≥ 47°C) at the dynamic bone-drill interface during dental implant osteotomy in pre-existing pilot bone cavities.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Bone samples were cut such that immediate and direct thermographic measurements at the dynamic bone-drill interface were possible. Osteotomy cavities of 2.4 mm width were expanded to either 3.2 or 3.8 mm in cortical bovine bone with a thickness of 3.5 mm, using two-bladed twist drills at rotational speeds of 200, 600, or 1000 rpm, with or without saline irrigation. A logistic regression model was developed to predict the likelihood of reaching temperatures ≥ 47°C during osteotomy based on these parameters.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The absence of irrigation, major osteotomy diameter expansion, and higher rotational speeds were identified as significant risk factors for increasing the bone-drill interface temperature by more than 10°C (OR: irrigation 177.53; expansion step 9.94; speed by 400 rpm 4.94). No osteotomy performed at a low rotational speed (200 rpm) resulted in a critical temperature rise in either drill diameter group when irrigation was provided. However, temperatures exceeded 47°C across all groups when irrigation was absent.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Dental implant osteotomy procedures without irrigation result in critical heat stress at the bone-drill interface, even at low drilling speeds. Shortened protocols with large drill diameter differences of up to 1.4 mm can be safely implemented when drilling at 200 rpm with irrigation. Osteotomy protocols can therefore be shortened while maintaining safety.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>No clinical trial was included in the study</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 9","pages":"1126-1135"},"PeriodicalIF":5.3,"publicationDate":"2025-06-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14462","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144295970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Horizontal and Vertical Intraoral Scan Bodies on the Trueness of Complete-Arch Digital Implant Impressions: A Comparative In Vitro Study With Six Implants","authors":"Luís Azevedo,&nbsp;Andrea Laureti,&nbsp;Tiago Marques,&nbsp;João Pitta,&nbsp;Vincent Fehmer,&nbsp;Alessandro Pozzi,&nbsp;Irena Sailer","doi":"10.1111/clr.14463","DOIUrl":"10.1111/clr.14463","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the interaction between intraoral scan body (ISB) type, operator, and intraoral scanner (IOS) selection on the trueness of complete-arch digital implant impressions. This study also compared horizontal ISBs (H-ISBs) and vertical ISBs (V-ISBs) across four IOS devices.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Digital impressions of a definitive mandibular cast with six multi-unit analogs were made using four H-ISBs from different manufacturers (denoted as H-NB, H-NS, H-M6, and H-SF), with a V-ISB (V-EA) as the reference. Each ISB was scanned using a desktop scanner and by two operators who scanned each ISB system 10 times using four IOS devices i5D, PS, T3, T4, generating 400 digital impressions. Deviations were measured using root-mean-square (RMS) error (<i>α</i> = 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All independent variables (operator, IOS, ISB) significantly affected trueness (<i>p</i> &lt; 0.05). V-EA with i5D had the lowest trueness (78 [27] μm), while H-NS on PS showed the highest (12 [3] μm). H-M6 maintained high trueness across IOS devices. PS was the most stable IOS, while T4 showed the most variability.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Complete-arch digital impressions are influenced by ISBs, IOSs, and operators. H-ISBs demonstrated better trueness and consistency across IOSs and operators.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 9","pages":"1136-1145"},"PeriodicalIF":5.3,"publicationDate":"2025-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144265507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implant Survival in Patient Populations With a Mean Age of 65–75 Years Compared to Older Cohorts: A Systematic Review and Meta-Analysis","authors":"Samir Abou-Ayash,&nbsp;Monika Bjelopavlovic,&nbsp;Pedro Molinero-Mourelle,&nbsp;Martin Schimmel","doi":"10.1111/clr.14456","DOIUrl":"10.1111/clr.14456","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate implant survival and success rates in elderly patients, comparing younger old adults (65–75 years) to older implant patients (&gt; 75 years).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>A systematic search was conducted using Medline, Cochrane Library, and PubMed Central for clinical studies on implant therapy in patients aged 65 and older. Outcomes included implant survival and success rates, peri-implant parameters, bone-level changes (BLC), and type of restoration and retention. Three- and five-year survival and success rates, as well as implant loss per 100 implant-years, were estimated with 95% confidence intervals (CI). Poisson regression models and incidence rate ratios (IRR) were used to compare study groups, and meta-regression with restricted maximum likelihood estimation (REML) assessed BLC.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-seven studies with a total of 3892 implants were included. Patients &gt; 75 years had significantly higher five-year survival rates (96.8%, CI: 95.9–97.5) compared to the 65–75 age group (92.1%, CI: 83.0–96.4; <i>p</i> = 0.031), with lower implant loss rates per 100 implant-years. No significant difference in success rates was observed (<i>p</i> = 0.229). Although plaque and bleeding on probing (BOP) were more frequent in the older group, there was no significant difference in BLC (mean difference: 0.41 mm; <i>p</i> = 0.189). In patients &gt; 65 with implant overdentures, single attachments showed significantly higher implant loss rates than bars (<i>p</i> = 0.035).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Dental implants are a reliable treatment for older adults, including those over 75 years. Despite more frequent plaque and BOP in the older group, peri-implant bone remained stable. Splinting implants in overdenture wearers aged &gt; 65 is associated with 5.6 times higher survival rates.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 9","pages":"1053-1074"},"PeriodicalIF":5.3,"publicationDate":"2025-06-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14456","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144237736","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison of AI-Powered Tools for CBCT-Based Mandibular Incisive Canal Segmentation: A Validation Study","authors":"Maria Fernanda Silva da Andrade-Bortoletto,&nbsp;Thanatchaporn Jindanil,&nbsp;Rocharles Cavalcante Fontenele,&nbsp;Reinhilde Jacobs,&nbsp;Deborah Queiroz Freitas","doi":"10.1111/clr.14455","DOIUrl":"10.1111/clr.14455","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Identification of the mandibular incisive canal (MIC) prior to anterior implant placement is often challenging. The present study aimed to validate an enhanced artificial intelligence (AI)-driven model dedicated to automated segmentation of MIC on cone beam computed tomography (CBCT) scans and to compare its accuracy and time efficiency with simultaneous segmentation of both mandibular canal (MC) and MIC by either human experts or a previously trained AI model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>An enhanced AI model was developed based on 100 CBCT scans using expert-optimized MIC segmentation within the Virtual Patient Creator platform. The performance of the enhanced AI model was tested against human experts and a previously trained AI model using another 40 CBCT scans. Performance metrics included intersection over union (IoU), dice similarity coefficient (DSC), recall, precision, accuracy, and root mean square error (RSME). Time efficiency was also evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The enhanced AI model had IoU of 93%, DSC of 93%, recall of 94%, precision of 93%, accuracy of 99%, and RMSE of 0.23 mm. These values were significantly higher than those of the previously trained AI model for all metrics, and for manual segmentation for IoU, DSC, recall, and accuracy (<i>p</i> &lt; 0.0001). The enhanced AI model demonstrated significant time efficiency, completing segmentation in 17.6 s (125 times faster than manual segmentation) (<i>p</i> &lt; 0.0001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The enhanced AI model proved to allow a unique and accurate automated MIC segmentation with high accuracy and time efficiency. Besides, its performance was superior to human expert segmentation and a previously trained AI model segmentation.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 9","pages":"1086-1094"},"PeriodicalIF":5.3,"publicationDate":"2025-06-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14455","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144236839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ridge Preservation in Extraction Sockets of Periodontally Compromised Molars With and Without Primary Wound Closure: Histological and 1-Year Implant Outcomes of a Clinical Trial","authors":"Yiping Wei,&nbsp;Anqi Tao,&nbsp;Wenjie Hu,&nbsp;Liping Zhao,&nbsp;Tao Xu,&nbsp;Yunsong Liu","doi":"10.1111/clr.14459","DOIUrl":"10.1111/clr.14459","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare the histological outcomes and 1 year implant treatment outcomes following alveolar ridge preservation (ARP) in extraction sockets of periodontally compromised molars with and without primary wound closure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Patients requiring molar extraction owing to severe periodontitis were allocated to one of the following groups: (1) ARP with primary wound closure (control group), and (2) ARP with minimally invasive open healing (test group). Six months after ridge preservation, trephine cores were harvested for histologic and histomorphometric analysis. Implants were then placed, and implant stability was measured immediately as well as 6 months after placement. Clinical and radiographic examinations were performed after the final crown insertion and again at 1 year post-procedure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-nine patients (39 implants) completed the study. Histomorphometrically, based on 30 participants, the percentage of newly formed bone was 33.7% ± 16.0% and 30.5% ± 14.4% in control and test groups, respectively. Control and test groups showed no significant differences in primary and secondary implant stabilities. No statistically significant differences in any of the clinical measurements were detected between the two groups (<i>p</i> &gt; 0.05). Marginal bone levels remained stable with minimal changes from crown placement to 1 year, measuring 0.32 ± 0.57 mm for the control group and 0.23 ± 0.31 mm for the test group. The survival rates of the implants were 100% in both groups at 1-year post-loading.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ARP with/without primary wound closure resulted in no significant differences in new bone formation and 1 year implant treatment outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>This study was registered in the Chinese Clinical Trial Registry (ChiCTR-ONN-16009433)</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 9","pages":"1106-1114"},"PeriodicalIF":5.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144224573","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bi-Layered Biphasic Calcium Phosphate Bone Substitute to Improve Bone Formation in Lateral Jaw Defects Applying the Principle of Guided Bone Regeneration (GBR)—A Pre-Clinical Randomized Controlled Study","authors":"Kiri N. Lang,&nbsp;Niklaus P. Lang,&nbsp;Fernando M. Muños Guzon,&nbsp;Nikola Saulacic","doi":"10.1111/clr.14460","DOIUrl":"10.1111/clr.14460","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate the application of a synthetic bi-layered biphasic calcium-phosphate (BBCP) bone substitute for its capacity for new bone formation in Guided Bone Regeneration (GBR) in an acute-defect model in Beagle dogs.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Standardized bone defects were created following the extraction of the maxillary ¹P¹, ²P², ⁴P⁴ and the mesial root of ³P³ in six Beagle dogs. The defects were treated according to the GBR principle using the tested material, synthetic bi-layered biphasic calcium-phosphate bone substitute (Group T), deproteinized bovine bone mineral (DBBM, positive control = PC), a mixture of the test substance and DBBM in a ratio of 1:1 (Group M) and a sham-operated empty control (negative control = NC). The defects were covered with a resorbable collagen barrier membrane. Bone formation was evaluated radiologically, microtomographically, and histomorphometrically after 11 weeks of healing.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>All biomaterials resulted in increased volume of the augmented bone compared to the negative control. The augmented ridge volume developed to a greater extent in the tested area and in the combination of the tested bone substitute and the DBBM compared to the positive control alone (DBBM). A significant increment in a mineralized tissue and bone-biomaterial contact was observed between the test groups and the positive control.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The synthetic BBCP appeared to result in greater bone formation volumes than the positive control (DBBM) and resulted in less contact with soft tissue. Hence, the tested material appeared to be at least as effective as the applied standard for lateral bone augmentation (DBBM).</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 9","pages":"1115-1125"},"PeriodicalIF":5.3,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14460","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144233392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multifactorial Analysis of Trueness in Computer-Assisted Implant Surgery: A Retrospective Study","authors":"Weie Song,&nbsp;Chen Deng,&nbsp;Chenyu Rao,&nbsp;Yilin Luo,&nbsp;Xingmei Yang,&nbsp;Yingying Wu,&nbsp;Yili Qu,&nbsp;Yi Man","doi":"10.1111/clr.14458","DOIUrl":"10.1111/clr.14458","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To investigate the clinically acceptable deviation threshold and the factors associated with trueness across three computer-assisted implant surgery (CAIS) approaches: static CAIS (s-CAIS), dynamic CAIS (d-CAIS), and robotic CAIS (r-CAIS).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A total of 314 implants in 194 patients were retrospectively included, with preoperative and postoperative CBCT scans collected. Outcome measures included platform, apex, and angular deviations, which were assessed by registering postoperative CBCT scans to preoperative implant plans using a jawbone matching technique. Generalized linear mixed models (GLMM) were employed to identify significant factors associated with implant trueness.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>In r-CAIS, mean global deviations were 0.65 ± 0.137 mm (platform), 0.73 ± 0.39 mm (apex), and 1.66° ± 0.99° (angular), significantly smaller than s-CAIS and d-CAIS (<i>p</i> &lt; 0.01). Deviations in d-CAIS were 1.15 ± 0.55 mm, 1.23 ± 0.56 mm, and 2.87° ± 1.71°, whereas s-CAIS showed 0.96 ± 0.56 mm, 1.32 ± 0.67 mm, and 3.42° ± 1.85°. No significant differences were found between s-CAIS and d-CAIS (<i>p</i> &gt; 0.01). All approaches met clinical acceptability thresholds of 1.5 mm for linear and 5° for angular deviation (<i>p</i> &lt; 0.01). Analysis revealed that bone inclinations exceeding 45° significantly increased implant deviations at apex and angular (<i>p</i> &lt; 0.01). Additionally, deviations were greater in the molar region, particularly at the second molar (<i>p</i> &lt; 0.01).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>All three CAIS approaches demonstrated clinically acceptable trueness, with the r-CAIS showing superior performance. Bone inclination and molar placement were identified as key factors contributing to increased deviations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Chinese Clinical Trial Registry: ChiCTR2400083777</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 9","pages":"1095-1105"},"PeriodicalIF":5.3,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144201427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}