{"title":"Oral Fine Motor Control in Patients With Anterior Maxillary Single Implants, Freestanding Teeth and Teeth Connected in 3-Unit Bridges: An Experimental In Vivo Study.","authors":"Nicole Winitsky, Aron Naimi-Akbar, Jan-Ivan Smedberg, Anastasios Grigoriadis","doi":"10.1111/clr.70136","DOIUrl":"https://doi.org/10.1111/clr.70136","url":null,"abstract":"<p><strong>Objectives: </strong>The oral fine motor control is compromised in patients with full-arch, bimaxillary bridges compared to those with natural teeth. No previous studies have examined the differences between the prosthetic treatments small anterior bridges and single anterior implants (SI). The aim of the study was to evaluate oral fine motor control in patients with single anterior tooth loss, comparing anterior teeth connected in 3-unit resin bonded bridges (RBB) and free-standing teeth adjacent to single implants (SI).</p><p><strong>Materials and methods: </strong>A standardized hold-and-split task was performed in 16 patients on two occasions: once, with a RBB in place and once after replacement with a SI. The four conditions connected tooth (CT), pontic (P), free-standing tooth (T), and single implant (SI) were tested. Outcome variables hold force, variability of hold force, split force, and duration of split were analyzed using paired sample t-test or Wilcoxon signed rank test, with a significance level set at p < 0.05.</p><p><strong>Results: </strong>The results showed significant differences between T and SI for all variables (p < 0.05) except for duration of split (p > 0.05), and between CT and P regarding hold force and duration of split. No significant differences were found between CT and T or P and SI for any of the outcome variables (p > 0.05).</p><p><strong>Conclusions: </strong>Oral fine motor control on a SI was compromised compared to a T and comparable to a P of a 3-unit RBB. However, splinting a tooth (CT) in a 3-unit anterior RBB does not seem to compromise the oral fine motor control.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":5.3,"publicationDate":"2026-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147855695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tonje Moen Eckhoff, Erik Klepsland Mauland, Anders Verket, Elisabeth Lind Melbye
{"title":"Reliability and Construct Validity of a Questionnaire for Assessment of Patient-Reported Outcomes in Implant Dentistry.","authors":"Tonje Moen Eckhoff, Erik Klepsland Mauland, Anders Verket, Elisabeth Lind Melbye","doi":"10.1111/clr.70110","DOIUrl":"10.1111/clr.70110","url":null,"abstract":"<p><strong>Objectives: </strong>The study aimed to evaluate the reliability and construct validity of a questionnaire assessing patient-reported outcomes following dental implant rehabilitation.</p><p><strong>Material and methods: </strong>A questionnaire was mailed to patients 8 years posttreatment to assess experiences with dental implant therapy, including satisfaction, oral function, perceived pretreatment information and complications. Patients completed the questionnaire again during a clinical examination. Internal consistency was evaluated using Cronbach's alpha and corrected item-total correlations (CITC), while test-retest reliability was assessed with intraclass correlation coefficients (ICC). Construct-related validity was examined through associations between questionnaire domains and oral health related quality of life (OHRQoL) measured by OHIP-14.</p><p><strong>Results: </strong>A total of 206 patients completed the questionnaire twice. For individual items, ICCs ranged from 0.39 to 0.75 and CITCs from 0.39 to 0.66. The full questionnaire had an alpha of 0.78 and an ICC of 0.78. Construct-related validity was supported through associations between the questionnaire domains patient satisfaction, pretreatment information and the OHIP-14 sum scores.</p><p><strong>Conclusions: </strong>The questionnaire demonstrated acceptable internal consistency reliability, good test-retest performance, and reasonable construct validity.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":"657-666"},"PeriodicalIF":5.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147282408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Vincenzo Iorio-Siciliano, Andrea Blasi, Leopoldo Mauriello, Peter Windisch, Giovanni E Salvi, Anton Sculean, Luca Ramaglia
{"title":"Non-Surgical Submarginal Instrumentation of Peri-Implant Mucositis With Delivery of Sodium Hypochlorite/Amino Acids and Cross-Linked Hyaluronic Acid: A Randomized Clinical Trial.","authors":"Vincenzo Iorio-Siciliano, Andrea Blasi, Leopoldo Mauriello, Peter Windisch, Giovanni E Salvi, Anton Sculean, Luca Ramaglia","doi":"10.1111/clr.70109","DOIUrl":"10.1111/clr.70109","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the effects of submarginal instrumentation (SI) with or without adjunctive delivery of sodium hypochlorite (NaOCl)/amino acids and cross-linked hyaluronic acid (xHyA) gel in the treatment of peri-implant mucositis (PM).</p><p><strong>Material and methods: </strong>Forty implants supporting single-unit crowns diagnosed with PM in 40 patients were randomly assigned to test (SI + NaOCl/amino acids and xHyA) or control group (SI alone). The primary outcome was mean BoP change. Full-Mouth Plaque Score (FMPS), Full-Mouth Bleeding Score (FMBS), modified plaque index (mPlI), and probing depth (PD) were assessed as secondary outcomes. Clinical parameters were assessed at baseline, 3 and 6 months. Disease resolution was also recorded.</p><p><strong>Results: </strong>Two patients were lost during follow-up while 38 patients completed the study without adverse effects. After 6 months, all clinical parameters improved statistically significantly in both groups (p < 0.05). The change in mean BoP at 1, 3, and 6 months was 72.2% ± 24.3%, 70.4% ± 24.3%, and 63.0% ± 24.6% for test group and 70.0% ± 19.9%, 66.7% ± 24.8%, and 56.7% ± 30.8% for control group. The mean BoP change in experimental procedure was statistically significant at all investigation time points (p < 0.05). Regarding disease resolution, implants with initial PD ≤ 4 mm did not show differences among groups (p > 0.05); conversely, an initial PD = 5 mm yielded a statistically significant difference (p < 0.05). Disease resolution correlation with test group was statistically significant with a 3.77 odds ratio.</p><p><strong>Conclusion: </strong>Within the limitations of the present study, adjunctive delivery of NaOCl/amino acids and xHyA to SI yielded superior clinical outcomes compared with SI alone in the treatment of PM.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov: NCT05926297.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":"643-656"},"PeriodicalIF":5.3,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147316619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Ten-Year Post-Loading Outcomes of Subcrestally Placed Implants With Internal Conical Connections at 0.5 mm Versus 1.5 mm Depth: A Multicentre Within-Person Randomised Controlled Trial.","authors":"Marco Esposito,Riccardo Federico Visconti,Federico Gualini,Fabio Rigotti,Cristian Mazzarini,Diego Longhin,Mauro Grigoletto,Amerigo Giudice,Katia Greco,Sergio Salina","doi":"10.1111/clr.70135","DOIUrl":"https://doi.org/10.1111/clr.70135","url":null,"abstract":"OBJECTIVESTo evaluate whether placing single dental implants either 0.5 or 1.5 mm subcrestally in healed bone crests confers any clinical benefits.MATERIALS AND METHODSSixty partially edentulous patients requiring two single implant-supported crowns were enrolled in a split-mouth design across six centres. Each site was randomly assigned to receive an implant placed either 0.5 or 1.5 mm subcrestally. Patients were followed up to 10 years post-loading. Outcome measures included crown and implant failures, complications, aesthetics assessed using the Pink Esthetic Score (PES), peri-implant marginal bone level changes, and patient preference.RESULTSEight patients were lost to follow-up. No statistically significant differences were observed between groups regarding implant failures (7 vs. 3; p = 0.125), patients experiencing complications (10 [18.5%] vs. 7 [13%]; p = 0.508), PES (7.66 ± 3.14 vs. 7.46 ± 2.97, p = 0.510). Ten years post-loading, patients in the 0.5 mm group exhibited an average marginal bone loss of 0.38 ± 0.84 mm, while those in the 1.5 mm group showed 0.17 ± 0.45 mm, a difference that was not statistically significant (difference = -0.21 mm; 95% CI -0.47 to 0.04; p = 0.097). No patient preference for implant placement depth was noted. No significant differences in outcomes were found between centres.CONCLUSIONSSubcrestal implant placement at either 0.5 or 1.5 mm, when at least 1 mm of surrounding bone is present, seems not to affect the long-term outcomes.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"32 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147754545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Emilio A. Cafferata, Frank Schwarz, Ausra Ramanauskaite
{"title":"EAO Monaco 2025—Report From the Joint 32nd EAO and SFPIO Congress","authors":"Emilio A. Cafferata, Frank Schwarz, Ausra Ramanauskaite","doi":"10.1111/clr.70133","DOIUrl":"https://doi.org/10.1111/clr.70133","url":null,"abstract":"","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"65 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Augmented Reality Improves Accuracy of Dynamic Computer-Assisted Implant Surgery: An In Vitro Analysis.","authors":"Arndt Guentsch,Shengtong Han","doi":"10.1111/clr.70134","DOIUrl":"https://doi.org/10.1111/clr.70134","url":null,"abstract":"OBJECTIVETo assess the accuracy of dynamic computer-assisted implant surgery (dCAIS) performed with and without augmented reality (AR) smart-glasses visualization under standardized laboratory conditions.MATERIALS AND METHODSA standardized typodont model with bounded and unbounded edentulous spaces was prepared to receive polyurethane blocks. Five implants were virtually planned using implant-planning software, and the plan was transferred to a miniaturized dynamic navigation system. Forty simulated surgeries (n = 40; total 200 osteotomies) were performed under two conditions: (a) standard screen-based guidance (dCAIS) and (b) smart-glasses guidance (dCAIS+SG) projecting real-time navigation data into the operator's field of view. Postoperative CBCT scans were used to compare planned and achieved osteotomies. The 3D deviation at the crestal level was defined as the primary outcome parameter. Means, standard deviations, and 95% confidence intervals were calculated, and data were analyzed using paired t-tests (trueness and precision).RESULTSThe mean 3D deviation at the crest was significantly lower with smart-glasses visualization (dCAIS: 0.32 ± 0.17 mm; dCAIS+SG: 0.27 ± 0.16 mm; p = 0.02), primarily due to reduced 2D mesiodistal deviation (0.20 ± 0.16 mm vs. 0.09 ± 0.07 mm; p < 0.0001). Angular deviation remained low and comparable between groups (0.40° ± 0.31° vs. 0.34° ± 0.35°; p = 0.2). Both workflows exhibited similar precision across all parameters.CONCLUSIONAR smart-glasses enhanced the trueness of dynamic navigation without affecting precision. Integrating AR into dCAIS enables continuous visualization of navigational data, potentially improving ergonomic workflow and maintaining visual focus on the surgical field.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"92 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147731416","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Effect of Crown Height and Retentive Height of Abutment on the Fracture Resistance of Fatigued Monolithic Zirconia Anterior Implant Crowns-An In Vitro Study.","authors":"Esha Zahid,Jaafar Abduo,Attila Gergely,Roy Judge,Carolina Perez-Rodriguez,Joseph Palamara","doi":"10.1111/clr.70130","DOIUrl":"https://doi.org/10.1111/clr.70130","url":null,"abstract":"OBJECTIVESThis laboratory study investigated the effect of two different retentive heights of Ti-base abutments (3.5 and 5.5 mm) and crown heights (13 and 16 mm) on the load at failure and survival of monolithic zirconia implant-supported crowns replacing a maxillary central incisor.MATERIALS AND METHODForty implant-supported crowns were divided into four groups (n = 10 each): short crown/long abutment (SCLA), short crown/short abutment (SCSA), long crown/long abutment (LCLA), and long crown/short abutment (LCSA). Specimens underwent thermal cycling and incremental mechanical cyclic loading starting at 450 N increasing by 50 N until failure. Load and cycles at failure, Weibull analysis, mode of failure, and fractographic assessments were performed.RESULTSMean load at failure was highest for the SCSA group (536.9 N ± 78.4 N), then SCLA (493.4 ± 53.2 N) and LCLA (491.3 ± 40.7 N), and lowest for the LCSA group (453.7 N ± 2.8 N). The differences were statistically significant (p = 0.035). Cycles at failure showed significant differences among groups (p < 0.001), with SCSA demonstrating the greatest cycles at failure (72,492 ± 44,551 cycles), then SCLA (43,630 ± 27,579 cycles) and LCLA (37,706 ± 18,826 cycles), and LCSA the lowest (8399 ± 7308 cycles). Short crowns showed abutment/screw fractures, while longer crowns had more crown fractures.CONCLUSIONCrown height significantly influenced load at failure and survival, with shorter crowns performing better. The retentive height of the Ti-base abutment had less impact; however, shorter abutments provided better mechanical performance when paired with shorter crowns, suggesting careful consideration for anterior restorations.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"15 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147719536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Crown Design, Cement Type and Margin Depth on the Removal of Cement Remnants Around Single Implant-Supported Restorations. An In-Vitro Study.","authors":"Shaza Bishti,Christiane Apeldorn,Anne Rittich,Stefan Wolfart,Taşkın Tuna","doi":"10.1111/clr.70129","DOIUrl":"https://doi.org/10.1111/clr.70129","url":null,"abstract":"OBJECTIVESTo assess the influence of crown design, cement type, and margin depth on the removal efficiency of residual cement around single implant-supported restorations.METHODSTwelve mandibular models with a missing first molar were fabricated and provided with single implant analogs (centrally/distally placed) and two different crown designs (non-cantilever/cantilever). Three of each design had either a superficial (SM = -1 mm) or a deep (DM = -2 mm) submucosal margin. Crown restorations were made from CAD/CAM titanium-base abutments and monolithic zirconia (n = 120). Three different cements (glass ionomer [GI], polycarboxylate [PC], dual-curing resin cement [RC]) were used in a standardized way for crown cementation. Ten dentists removed excess cement using metal scalers. The volumetric values of residual cement were calculated (mm3). Statistical analyses assessed the effects of the investigated variables on residual cement volume (p < 0.05).RESULTSThe overall analysis showed no significant differences in the volume of cement remnants between both crown designs (non-cantilever: 0.42 ± 0.96 mm3; cantilever: 0.52 ± 0.98 mm3; p > 0.05). For crown margin depth, a significantly higher cement volume for deeper margins (SM: 0.28 ± 0.62 mm3; DM: 0.68 ± 1.19 mm3; p < 0.05) was found. The highest volume of cement remnants was found in the non-cantilever_DM_RC (1.19 ± 1.83 mm3), whereas the lowest value was found in non-cantilever_SM_GI and cantilever_SM_GI (0.00 ± 0.00 mm3). While crown design alone showed no statistically significant effect, its interaction with cement type was associated with improved cement removal in the cantilever group.CONCLUSIONCrown margin depth emerged as the dominant factor influencing cement removal. Although cement type also affected residual cement, with glass ionomer showing lower values overall, crown design did not provide a consistent advantage.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"17 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Clemens Raabe,Manrique Fonseca,Vivianne Chappuis,Gustavo Avila-Ortiz,Diogo Moreira Rodrigues,Pablo Galindo-Moreno,Emilio Couso-Queiruga
{"title":"Association of Transmucosal Emergence Geometry and Peri-Implant Diseases Prevalence Around Bone- and Tissue-Level Implants: A Cross-Sectional Study.","authors":"Clemens Raabe,Manrique Fonseca,Vivianne Chappuis,Gustavo Avila-Ortiz,Diogo Moreira Rodrigues,Pablo Galindo-Moreno,Emilio Couso-Queiruga","doi":"10.1111/clr.70131","DOIUrl":"https://doi.org/10.1111/clr.70131","url":null,"abstract":"OBJECTIVESThis cross-sectional study primarily aimed at investigating the association between the transmucosal emergence geometry and the prevalence of peri-implant diseases in bone- and tissue-level implants (BL/TL). As secondary objectives, the association of other implant-, prosthesis-, and patient-related variables with crestal bone levels (CBL) and additional radiographic findings was explored.MATERIAL AND METHODSPatients with non-molar single tooth implant-supported prostheses were retrospectively identified for inclusion. Clinical and radiographic examinations were performed cross-sectionally to assess peri-implant diseases (peri-implant mucositis, peri-implantitis), emergence geometry at the transmucosal region (profile type, emergence angles at two levels, and prosthetic platform height), and peri-implant radiographic variables, including CBL. Data were analyzed using multivariate regression.RESULTSA total of 332 implants (166 BL/166 TL) in 266 patients (60 ± 17 years) were evaluated at a mean of 11.2 ± 1.5 years after implant placement. Peri-implant mucositis was significantly influenced by the crown emergence angle (Level 2; OR = 1.03, p = 0.01) and peri-implantitis by implant diameter (OR = 3.82, p < 0.0001). Crown emergence angles > 30° in BL implants and > 48° in TL implants were consistently associated with peri-implant diseases. Mean CBL was 0.54 ± 1.34 mm, with lower values in TL (-0.24 mm; p = 0.036), females (-0.27 mm, p = 0.029), and implants with greater platform height (-0.175 mm/mm, p = 0.01). Peri-implant sheathing was detected in 13.4% of implants, showing no association with implant-related characteristics.CONCLUSIONSWider crown emergence angles were associated with peri-implant diseases, whereas wider implant diameters were associated with increased peri-implantitis prevalence. TL implant design and greater platform height were associated with reduced CBL.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"321 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147663675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ting Wang, Yuchen Shan, Tymour Forouzanfar, Junwei Liang, Zimu Zhao, Ping Sun, Gang Wu, Haiyan Lin
{"title":"The Efficacy of Three Combinatory Decontamination Protocols and BMP ‐2‐Incorporated BioCaP ‐Based Regenerative Material in Treating Implants With Peri‐Implantitis In Vivo","authors":"Ting Wang, Yuchen Shan, Tymour Forouzanfar, Junwei Liang, Zimu Zhao, Ping Sun, Gang Wu, Haiyan Lin","doi":"10.1111/clr.70126","DOIUrl":"https://doi.org/10.1111/clr.70126","url":null,"abstract":"Objective To screen decontamination efficacy of three combinatory protocols and to evaluate the regenerative efficacy of bone morphogenetic protein 2‐incorporated biomimetic calcium phosphate granules (BMP2‐inc. BioCaP) in treating implants with peri‐implantitis. Material and Methods Peri‐implantitis model was established on 24 dental implants in 6 beagle dogs. The implants were decontaminated using mechanical curettage (MC) with either Chlorhexidine (CHX), photodynamic therapy (PDT), or both. The decontamination efficacy was assessed by measuring modified Sulcus Bleeding Index (mSBI), probing pocket depth (PPD), peri‐implant sulcular fluid (PISF), and inflammatory cytokines of crevicular fluid (IL‐8, IL‐1β). Thereafter, GBR surgery was performed either without (Control) or with deproteinized bovine bone mineral (DBBM) or with BMP2‐inc. BioCaP. Three fluoresceins were consequentially injected to assess bone growth rates. Eight weeks post‐surgery, samples were subjected to micro‐CT, confocal laser scanning microscopy and histomorphometric analyses. Results MC + CHX + PDT was associated with the lowest levels of mSBI, PPD, PISF, IL‐1β, and IL‐8 2 weeks post decontamination. Eight weeks post GBR surgery, BMP2‐inc. BioCaP yielded significantly higher bone volume fraction, trabecular thickness, trabecular number, bone mineral density, and significantly lower trabecular separation than DBBM and Control. BMP2‐inc. BioCaP bore significantly higher total fluorescence intensities than DBBM and Control at 2, 4, and 6 weeks, and was also associated with significantly higher bone‐to‐implant contact and new bone height than DBBM and Control. Conclusions Within the limitations of this study, MC + CHX + PDT decontamination and BMP‐2‐incorporated BioCaP showed an application potential in treating peri‐implantitis. Further studies with a long monitoring span are necessary before clinical application.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"43 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147636049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}