Clinical Oral Implants Research最新文献

{"title":"Peri-Implantitis Prevalence and Risk Indicators in Patients Seen at Periodontal Units in Malaysia: A Multicenter Cross-Sectional Study","authors":"Mohamad Adib Jaafar,&nbsp;Norhayati Abas,&nbsp;Khamiza Zainol Abidin,&nbsp;Normah Yacob,&nbsp;Norul Nurdiyana Nordin,&nbsp;Izni Iwani Majid,&nbsp;Zuhrah Mohd Sood,&nbsp;Lau Guat Syin,&nbsp;Heng Wei Chei,&nbsp;Tan Wan Jiun,&nbsp;Rasidah Ayob","doi":"10.1111/clr.70166","DOIUrl":"10.1111/clr.70166","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To determine the prevalence and identify risk indicators for peri-implant mucositis (PIM) and peri-implantitis (PI) among implant patients in Malaysian periodontal units.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This multicenter cross-sectional study included 352 patients with 647 implants (mean loading time 6.5 ± 4.0 years) across seven Malaysian states. Clinical evaluation included full-mouth plaque and bleeding scores (FMPS, FMBS), probing depth, tissue phenotype, and prosthetic condition. Peri-implant conditions were classified according to 2017 World Workshop definitions. Generalized Estimating Equation models identified risk indicators.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Healthy was observed in 53.7% of patients and 59.7% of implants. PIM affected 36.4% of patients and 31.5% of implants; PI affected 9.9% of patients and 8.8% of implants. Bone-level implants and keratinized tissue width (KTW) &lt; 2 mm were common risk indicators for both conditions. At patient level, FMBS ≥ 10% predicted PI (OR 2.41; 95% CI 1.19–5.05), and ≥ 3 implants were associated with PIM (OR 1.78; 95% CI 1.02–3.11). At implant level, PI was further associated with poor prosthetic condition (OR 4.94; 95% CI 2.38–10.26), splinted crowns (OR 3.48; 95% CI 1.06–11.42), and bridge restorations (OR 3.32; 95% CI 1.31–8.42). No associations were found for age, sex, smoking, or diabetes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Peri-implantitis affect one in ten implant patients. Due to modest sample size and wide confidence intervals, these findings are exploratory and hypothesis-generating. Potential risk indicators including elevated FMBS, reduced KTW, defective prostheses, and bone-level implants highlight the need for routine assessment of tissue phenotype and prosthetic integrity during maintenance care.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 11","pages":"1249-1259"},"PeriodicalIF":5.9,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148663433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Three-Year Follow-Up of Clinical, Radiographic, and Patient-Reported Outcomes for Zirconia and Titanium Implants in the Posterior Region: A Randomized Controlled Trial","authors":"Anina N. Zuercher,&nbsp;Ronald E. Jung,&nbsp;Stefan P. Bienz,&nbsp;Stephanie A. Wenk,&nbsp;Daniel S. Thoma,&nbsp;Marc Balmer","doi":"10.1111/clr.70176","DOIUrl":"10.1111/clr.70176","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To compare the 3-year clinical, radiographic, esthetic, and patient-reported outcomes of zirconia (Zr) and titanium (Ti) implants placed in posterior sites in a randomized, controlled within-subject design.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Forty-two patients each received one Zr and one Ti implant. Clinical and radiographic outcomes were evaluated at baseline, 1, and 3 years after crown delivery. Marginal bone levels (MBL), peri-implant soft-tissue parameters, technical complications, esthetic outcomes (Δ<i>E</i> values, VAS scores), and patient-reported measures were assessed. Thirty-nine patients (37 Zr; 39 Ti implants) were available at 3 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The 3-year survival rate was 100% for Ti and 94.9% for Zr implants. MBL remained stable after the initial remodeling phase, with no clinically relevant differences between materials. Peri-implant soft-tissue conditions (BOP, plaque presence, PD, KT) were similar for Zr and Ti. Two zirconia implants were lost during the observation period. Peri-implantitis was diagnosed in 7.9% of the implants, affecting three titanium and three zirconia implants. Technical complications differed between groups: chipping occurred significantly more often at Zr implant-supported crowns. Ti implants showed two screw-loosening events, while Zr implants showed two cases of decementation. Esthetic and patient-reported outcomes were comparable, with low perceived mucosal color differences and a slight preference for Zr sites, if detectable.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Zr and Ti implants showed similar peri-implant health, marginal bone stability, esthetic outcomes, and patient satisfaction after 3 years. Zr implants, however, demonstrated a slightly lower survival rate and more chipping.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>The trial is registered in the German Clinical Trials Register (DRKS) under the ID DRKS00008591</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 11","pages":"1350-1362"},"PeriodicalIF":5.9,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70176","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149151796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Outcomes of Fixed Dental Prostheses Supported by Teeth or Implants in the Posterior Region—A Long-Term Retrospective Multicenter Study","authors":"Zahra Athab Abduljabbar,&nbsp;Lars Hjalmarsson,&nbsp;Victoria Franke Stenport,&nbsp;Jir Barzangi,&nbsp;Anders Magnuson,&nbsp;Alf Eliasson","doi":"10.1111/clr.70169","DOIUrl":"10.1111/clr.70169","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Background</h3>\u0000 \u0000 <p>Few long-term studies compare tooth- and implant-supported fixed dental prostheses (FDPs) in the posterior region.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To compare the 5- and 10-year survival and complication outcomes of tooth- and implant-supported FDPs and to assess patient-reported effects.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>This retrospective multicenter clinical study investigates patients treated with 3–5 units tooth-supported fixed dental prostheses (TSFDPs) and 1–4 units implant-supported FDPs in the posterior region at two specialist dental clinics (2009–2019) using clinical and radiographical examinations and Oral Health Impact Profile-14 (OHIP-14). Survival, biological, and technical complications as well as patient-reported effects were recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 180 patients with 238 FDPs: 113 TSFDPs, 71 implant-supported crowns (ISCs), and 54 implant-supported fixed partial prostheses (ISFPPs) were examined after a mean follow-up of 10 years. The 5-year cumulative survival rate for TSFDPs and implant-supported FDPs was 98% (<i>p</i> = 0.71). The 10-year cumulative survival rates were 94% for TSFDPs and 93% for implant-supported FDPs (<i>p</i> = 0.87). Eight TSFDPs, three ISCs, and five ISFPPs failed. Biological complications were recorded in 24.8% of TSFDPs and in 9.6% of implant-supported FDPs (<i>p</i> = 0.012). Technical complications were recorded in 29.9% of TSFDPs and in 27% of implant-supported FDPs (<i>p</i> = 0.62). Low OHIP-14 scores were reported in patients with tooth-supported (4.8 ± 6.7), implant-supported (3 ± 4.3), and with both types of FDPs (3.5 ± 3.6). Scores that indicate a good OHRQoL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Tooth- and implant-supported FDPs had high survival rates after 5 and 10 years. Biological complications had the highest impact on prostheses failure.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 11","pages":"1260-1276"},"PeriodicalIF":5.9,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70169","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148768314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retrospective Evaluation of Zygomatic Implant Therapy in Patients With Severe Tooth Agenesis and Maxillary Deficiencies: Clinical Outcomes and Safety up to 15 Years of Follow-Up","authors":"Baoxin Tao,&nbsp;Feng Wang,&nbsp;Yihan Shen,&nbsp;Yiqun Wu","doi":"10.1111/clr.70174","DOIUrl":"10.1111/clr.70174","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>This retrospective study analyzed the clinical data of 27 patients with severe tooth agenesis who underwent zygomatic implants (ZIs) over the past 15 years, with an aim of evaluating the efficacy and safety of ZIs in patients with severe oligodontia and anodontia.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Patients who were diagnosed with severe oligodontia or anodontia and treated with ZI were included. All the patients received comprehensive preoperative assessments, including radiographic imaging, genetic testing, and multidisciplinary consultations to develop customized treatment plans. The treatment strategies primarily involved extensive bone grafting combined with multiple conventional implants (CIs) and a single ZI approach or the Quad Zygoma approach. Postoperative rehabilitation involved immediate or delayed loading with provisional prostheses, followed by definitive full-arch implant-supported restorations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Twenty-seven patients with 20 patients exhibiting syndromes, aged 18–37 years (mean age 22.63), were enrolled. A total of 85 ZIs and 42 CIs were placed in the maxilla. All the ZIs achieved successful osseointegration, yielding an early survival rate of 100%. The crude survival rates of ZIs and CIs were 98.5% (84/85) and 76.19% (32/42) at the implant level and 96.3% (26/27) and 64.71% (11/17) at the patient level, respectively, with a mean follow-up of 55.07 months (range: 13.27–179.2 months). The main complications associated with ZIs included maxillary sinus opacification and peri-implant soft-tissue recession.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>ZIs could be a treatment option for patients with severe oligodontia and anodontia. This study may support the feasibility and favorable outcomes of ZIs in the management of severe tooth agenesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 11","pages":"1313-1327"},"PeriodicalIF":5.9,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148964278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Risk Factors for Implant Failure and Peri-Implantitis: A Retrospective Cohort Study","authors":"Nathalia Vilela,&nbsp;Bruno C. V. Gurgel,&nbsp;Hélio D. P. da Silva,&nbsp;Claudio M. Pannuti,&nbsp;Poliana M. Duarte","doi":"10.1111/clr.70181","DOIUrl":"10.1111/clr.70181","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This retrospective cohort study evaluated patient-, implant-, site-, procedural-, biological-, and prosthesis/mechanics-related factors associated with early and late implant failure and peri-implantitis.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Electronic health record data from a university center were analyzed. Forty patient-, implant/site-, biologic-, and prosthesis-related variables were evaluated in relation to early failure, late failure, and peri-implantitis. Bivariate and survival analyses were performed, followed by mixed-effects regression models appropriate to each outcome. Robustness was assessed via clustered bootstrap resampling, penalized regression, and sensitivity analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 264 patients and 554 implants were assessed. Cumulative implant failure was 6.8% (3.4% early; 3.4% late), and peri-implantitis incidence was 7.6%. In multivariable analyses, self-reported penicillin allergy (OR = 7.9; 95% CI: 2.7–23.7) and anterior implant location (OR = 5.4; 95% CI: 2.0–14.0) were associated with higher odds of early implant failure, whereas antihypertensive medication use (OR = 0.26; 95% CI:0.08–0.91) was associated with lower odds (<i>p</i> &lt; 0.05). Late implant failure was associated with hypertension (HR = 2.1; 95% CI: 1.3–3.3), previously grafted sites (HR = 1.4; 95% CI:1.0–1.9), and bone-level implants (HR = 10.4; 95% CI: 5.5–19.5). In cluster-robust sensitivity analysis, the association between bone-level implants and late implant failure was attenuated but remained significant (HR = 3.38; 95% CI: 1.96–5.84). Peri-implantitis was associated with periodontitis (HR = 3.6; 95% CI: 1.89–6.97), excess cement (HR = 2.7; 95% CI: 1.25–5.88), and PLCBL (HR = 2.1; 95% CI: 1.09–4.13) (<i>p</i> &lt; 0.05). Robustness analyses generally supported the direction of the identified associations, although some effect estimates were attenuated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Implant failure and peri-implantitis are associated with distinct, potentially modifiable patient- and treatment-related factors. Recognition of these factors may help identify patients and implants at increased risk of adverse outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 11","pages":"1386-1401"},"PeriodicalIF":5.9,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70181","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149043547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Pterygoid Implant Placement With Augmented and Mixed Reality Navigation: An In Vitro Study","authors":"Wen Ma,&nbsp;Jiang Fu,&nbsp;Florian Beuer,&nbsp;Gülce Cakmak,&nbsp;Stefano Pieralli,&nbsp;Shenghui Liao,&nbsp;Ming Li,&nbsp;Zhen Mao","doi":"10.1111/clr.70173","DOIUrl":"10.1111/clr.70173","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the accuracy of augmented reality (AR) and mixed reality (MR)-assisted technologies for pterygoid implant trajectory guidance under anatomically challenging posterior maxillary conditions in the in vitro experimental model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Cone beam computed tomography datasets from eight patients were used to reconstruct three-dimensional (3D) models of the pterygoid-maxillary complex. Virtual implant placement was performed in planning software, and the corresponding standard tessellation language (STL) files were exported as the preoperative reference. For each patient, four resin models were fabricated and randomly assigned within the patient to the four implant placement techniques (free hand [FH]; static guide [SG]; AR; MR), resulting in 32 models in total. A surgeon placed 36 implants in all models according to group designs. Following implant placement, each model was digitized, and STL datasets were generated. These were superimposed with the preoperative reference STL in 3D analysis software, allowing calculation of angular and linear deviation. One-way repeated measures ANOVA was applied to compare deviations among groups, with significance set at <i>p</i> &lt; 0.05.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The SG group demonstrated the highest accuracy (coronal deviation 0.86 ± 0.73 mm; apical deviation 1.26 ± 0.60 mm; angular deviation 3.77° ± 1.84°). In contrast, the FH, AR, and MR groups exhibited greater deviations in all parameters, with the MR group showing the largest errors—particularly in apical deviation (3.81 ± 1.47 mm) and angular deviation (12.37 ± 5.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Within the limitations of the in vitro model, the AR and MR-assisted technologies tested in this study demonstrated limited accuracy for pterygoid implant placement.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 11","pages":"1301-1312"},"PeriodicalIF":5.9,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148909277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteogenic Outcomes and Associated Modifiable Factors of 3D-Printed Individual Titanium Mesh Exposure: A Retrospective Analysis","authors":"Minxue Yang,&nbsp;Yaxin Bai,&nbsp;Yuling Yang,&nbsp;Yujie Zhu,&nbsp;Houqi Zhou,&nbsp;Yuanding Huang,&nbsp;Tao Chen","doi":"10.1111/clr.70171","DOIUrl":"10.1111/clr.70171","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To identify independent risk factors for titanium mesh exposure following 3D-printed individualized titanium mesh (3D-PITM)-assisted alveolar bone augmentation and to evaluate the impact of exposure on bone regeneration outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Method</h3>\u0000 \u0000 <p>This retrospective study included 52 patients with severe alveolar bone defects who underwent 3D-PITM-assisted guided bone regeneration (GBR) between January 2019 and August 2025, comprising 25 patients with mesh exposure and 27 without. Demographic characteristics and surgery-related variables were collected; univariate analysis and multivariate logistic regression were performed to identify independent risk factors. Additionally, this study measured bone volume, bone height, and bone width at different time points to evaluate the impact of 3D-PITM exposure on bone augmentation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The results showed that smoking, thin gingival biotype, and maxillary defects were significantly associated with mesh exposure (<i>p</i> &lt; 0.05): smoking (OR = 5.16, 95% CI: 1.28–20.82, <i>p</i> = 0.021), thin gingival biotype (OR = 4.21, 95% CI: 1.05–16.82, <i>p</i> = 0.042), and maxillary defects (OR = 11.49, 95% CI: 1.25–105.68, <i>p</i> = 0.031). Regarding bone augmentation, the exposure group showed significantly greater resorption in bone volume (<i>p</i> = 0.0063), height (<i>p</i> &lt; 0.0001), and width (<i>p</i> &lt; 0.0001) than the nonexposure group. Moreover, early exposure resulted in more severe bone loss than late exposure across bone volume (<i>p</i> = 0.0048), height (<i>p</i> = 0.0019), and width (<i>p</i> &lt; 0.0001).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study found that 3D-PITM exposure significantly impairs bone regeneration, with smoking, thin gingival biotype, and maxillary defects identified as independent risk factors. Preoperative identification of these risk factors may help reduce mesh exposure and improve bone augmentation outcomes.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 11","pages":"1277-1289"},"PeriodicalIF":5.9,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148842924","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Premature Occlusal Contacts Induce MRONJ in Osseointegrated Dental Implants: An Experimental In Vivo Study","authors":"Eun-Bin Bae,&nbsp;Ahana Goswami,&nbsp;Jun Yaung,&nbsp;Soo Yeon Kim,&nbsp;Sherry S. Baik,&nbsp;Kaylyn A. Yu,&nbsp;Chan Park,&nbsp;Jung-Bo Huh,&nbsp;Jae-Young Kim,&nbsp;Christine Y. Hong,&nbsp;Sol Kim,&nbsp;Reuben H. Kim","doi":"10.1111/clr.70191","DOIUrl":"10.1111/clr.70191","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Medication-related osteonecrosis of the jaw (MRONJ) is a debilitating condition associated with antiresorptive agents (ARAs) and can occur around well-osseointegrated dental implants. Although implant presence–triggered osteonecrosis (IPTO) has been primarily linked to bacteria-related peri-implantitis, whether occlusal trauma contributes to IPTO remains unclear. Therefore, this study developed a novel premature occlusal contact (POC) mouse implant model to evaluate the effect of occlusal trauma on MRONJ development around osseointegrated implants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Eighteen mice underwent bilateral maxillary first molar extraction followed by immediate implant placement. After a 3-week healing period to allow osseointegration, mice were randomized to receive intravenous zoledronic acid (ZOL, 125 μg/kg) or saline vehicle (Veh) twice weekly (<i>n</i> = 9 per group). One week later, POC was induced in a split-mouth design by applying composite resin to one implant, whereas the contralateral implant served as a control. After 5 weeks of occlusal loading, mice were euthanized for μCT and histological analyses.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>μCT analysis revealed that POC reduced radiographic bone-to-implant contact (rBIC) in both Veh- and ZOL-treated mice. POC significantly increased empty lacunae around the implant neck in Veh-treated mice, whereas in ZOL-treated mice, POC induced extensive circumferential bone necrosis around the implant, accompanied by increased macrophage infiltration. No significant differences in peptidoglycan (PGN)-positive signals were observed among the experimental groups.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>These findings suggest that POC contributes to peri-implant osteonecrosis under ZOL treatment, supporting occlusal trauma as an important local factor in MRONJ development around osseointegrated dental implants.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 11","pages":"1420-1430"},"PeriodicalIF":5.9,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70191","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149226485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Randomized Controlled Clinical Trial Comparing Screw-Retained Monolithic Zirconia Implant Crowns on Standardized Titanium Base Versus Customized Titanium Abutments– 3-Years Data","authors":"Jenni Hjerppe,&nbsp;Stephanie Wenk,&nbsp;Shunsuke Fukuba,&nbsp;Sven Mühlemann,&nbsp;Ronald E. Jung,&nbsp;Daniel S. Thoma","doi":"10.1111/clr.70165","DOIUrl":"10.1111/clr.70165","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To assess 3-year interim results of implant-supported monolithic zirconia single crowns on standardized titanium base vs. customized titanium abutments.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Patients in need of posterior implant were recruited. After implant healing time, patients were randomly allocated to: Ti-Base (<i>n</i> = 30) with a monolithic zirconia crown on a standardized Ti-Base abutment or Custom (<i>n</i> = 30) with a monolithic zirconia crown on a customized titanium abutment. Implant crowns were evaluated at Baseline (BL), 1-year (1Y-FU), and 3 years (3Y-FU) follow-ups for marginal bone level changes (MBL), survival, biological and technical outcomes, and PROMs. Chi-squared and Fisher's exact test were used to assess association between categorical variables, Mann–Whitney's test to compare the distribution of parameters between groups, with a significance level of 5<i>%</i> (α = 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Fifty-one patients (23 Custom, 28 Ti-Base) attended 3Y-FU visit. No implant crowns were lost. Similar median MBL changes from BL to 3Y-FU and comparable biological outcomes were observed in both groups (<i>p</i> &gt; 0.05). No major technical complications were observed, but one minor chipping of Ti-Base zirconia crown was recorded at 3Y-FU, resulting in a technical complication rate of 3.6% for this group. At the 3Y-FU, all patients in the Custom group and 26 patients (92.9%) in the Ti-Base group were very satisfied with the treatment (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Within the limitations of this interim analysis, monolithic zirconia single crowns on either standardized titanium base or customized titanium abutments demonstrated stable marginal bone levels, high survival rates, high patient satisfaction, and no major technical complications during the 3Y follow-up period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>\u0000 https://drks.de/search/en/trial/DRKS00012733\u0000 </p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 11","pages":"1233-1248"},"PeriodicalIF":5.9,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70165","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148675372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patients' Experiences and Satisfaction With Immediate-Loaded Zygomatic Implant Fixed Rehabilitation: A Qualitative Study","authors":"Anisha Rodrigues,&nbsp;Samer Abi Nader,&nbsp;Nach Daniel,&nbsp;Elham Emami","doi":"10.1111/clr.70172","DOIUrl":"10.1111/clr.70172","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To obtain an in-depth understanding of patients' perspectives, their experiences and satisfaction with immediate-loaded zygomatic implant (ILZI) fixed rehabilitation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>This qualitative study employed interpretive descriptive methodology and was conducted as the second phase of our previous quantitative study on patient-reported outcomes with ILZI fixed rehabilitation. An adapted version of Pernerger's model of patient satisfaction and the patient experience framework by Oben were used as theoretical frameworks for the study. Purposive sampling with maximum variation was used to select participants from Phase 1 of the study, and others aged over 18 years with completely edentulous atrophic maxilla who had received ILZI rehabilitation. In-depth, 40 to 60-min face-to-face or telephone interviews were conducted using an interview guide until data saturation was reached. The interviews were recorded with an audio recorder and transcribed verbatim. Data analysis included transcription, debriefing, coding, thematic analysis, triangulation, and interpretation.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirteen participants were interviewed (mean age, 68.2 ± 7.41 years). Drawing from the study's conceptual frameworks, four major themes were identified: <i>Tooth loss experience</i>, <i>Handling the burden of maxillary atrophy, The choice of immediate-loaded zygomatic implant rehabilitation</i> and <i>Satisfaction with immediate-loaded zygomatic implants</i>. Participants expressed positive experiences with the rehabilitation, high satisfaction, favorable functional and psychosocial outcomes and strong clinician-patient relationships.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study findings provide insights into ILZI fixed rehabilitation from the patient's perspective that can inform treatment planning and shared decision-making for individuals with atrophic edentulous maxilla.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 11","pages":"1290-1300"},"PeriodicalIF":5.9,"publicationDate":"2026-11-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70172","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148973428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}