Clinical Oral Implants Research最新文献

{"title":"Peri‐Implant Conditions During Supportive Periodontal Care: A Prospective Study","authors":"Margherita Sforza, Pasquale Santamaria, Aliye Akcalı, Luigi Nibali","doi":"10.1111/clr.70026","DOIUrl":"https://doi.org/10.1111/clr.70026","url":null,"abstract":"AimTo assess peri‐implant conditions in a cohort of patients previously treated for periodontitis undergoing supportive periodontal care (SPC).Materials and MethodsA prospective observational study was carried out on previously treated periodontitis patients followed for 5 years in SPC. Peri‐implant diagnosis at baseline and the end of the 5‐year period was assessed.ResultsTwo hundred patients were included in the study. A total of 88 implants were present at baseline in 31 of those patients. A total of 55 (62.5%) implants were diagnosed as having healthy peri‐implant tissues, while 22 (25%) were diagnosed with peri‐implant mucositis and 11 (12.5%) with peri‐implantitis. Five‐year data are available for 68 implants in 23 patients. None of these implants was lost during the 5 years follow‐up. An additional 20 implants were placed during the study period, resulting in a total of 88 implants reassessed at the last study follow‐up, with peri‐implant diagnosis almost unchanged compared with baseline. None of the studied patient and implant factors were associated with implant diagnosis in a multilevel model with logistic regression target distribution.ConclusionsA small percentage of implants in a population undergoing SPC were diagnosed with peri‐implantitis, and peri‐implant conditions were maintained almost unchanged during 5 years of SPC.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"120 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144910958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Trends in the Prevention of Peri‐Implantitis: Spanish Society of Periodontology (SEPA) Foundation Survey Using the Delphi Method","authors":"Alberto Monje, Ana Molina, Olalla Argibay, Beatriz de Tapia, Jan Derks, Elena Figuero, Adrián Guerrero, Fernando Luengo, Eduardo Montero, Ignacio Sanz‐Martín, Ignacio Sanz‐Sánchez, Cristina Vallés, José Nart","doi":"10.1111/clr.70030","DOIUrl":"https://doi.org/10.1111/clr.70030","url":null,"abstract":"ObjectiveTo assess clinical trends to prevent peri‐implantitis in applying a two‐step survey based on the Delphi method.Material and MethodsA panel of participants aged < 45 years old selected by the Spanish Society of Periodontology (SEPA) was asked to answer a survey with 75 statements prepared by a steering committee. Items were divided into 5 major areas: etiopathogenesis and epidemiology, surgical, implant, and prosthetic‐related factors on the onset/progression of peri‐implantitis, and self‐ and professional‐administered oral hygiene. Degree of agreement or disagreement among participants was reported.ResultsIn total, 44 participants responded favorably to participate in the survey. From the 75 statements formulated, 35 were agreed on in a first round (46.7%). From the 40 statements that did not reach consensus, 16 were agreed on in a second round (40.0%). Overall, 51 out of 75 statements (68.0%) achieved consensus in a second round. From these, 36 (48.0%) were in agreement, while 15 (20.0%) were in disagreement. The sections that explored surgical‐related factors and prosthesis‐related factors of peri‐implantitis yielded the highest level of conflict (9/18 and 8/14 statements demonstrated indeterminate agreement, respectively). In the sections on the etiopathogenesis and epidemiology of peri‐implantitis and implant‐related factors, most items reached consensus (14/17 and 10/13 items, respectively). The section on self‐ and professional‐administered oral hygiene obtained the highest level of consensus, with only 1/13 items showing dissent among the participants.ConclusionThe results of this study on the clinical trends in the prevention of peri‐implantitis showed consensus agreement for ∼70% of the statements evaluated.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"11 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144915363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effect of Restorative Emergence Angle on Soft and Hard Tissue Around Splinted Implants: A Preclinical Study","authors":"Seung‐Ju Lee, Yuseung Yi, Frank Schwarz, Jungwon Lee, Ki‐Tae Koo","doi":"10.1111/clr.70035","DOIUrl":"https://doi.org/10.1111/clr.70035","url":null,"abstract":"ObjectiveTo investigate the impact of the restorative emergence angle and splinting configurations on peri‐implant soft and hard tissues.Materials and MethodsThirty implants were placed in the mandibular premolars (P2, P3, P4) of five beagle dogs. In a split‐mouth design, each animal received both narrow (NE) (emergence angle = 30°) and wide (WE) (emergence angle = 60°) abutments on each side of the mandible. The implants were subsequently splinted. Radiographic images were captured at 0, 4, 12, and 24 weeks post‐restoration. Biopsy samples were then collected for histomorphometric analysis and circularly polarized light examination. All analyses were performed based on the splinted positions: either the mesial or distal end of the terminal implant, the splinted zone of the terminal implant, or the splinted zone of the middle implant.ResultsRadiographic evaluation showed more pronounced bone remodeling in the WE group. In histomorphometric analysis, both the vertical distance from the implant shoulder to the alveolar bone crest and the infiltrated connective tissue areas were significantly larger in the WE group. Conversely, the NE group exhibited a longer connective tissue attachment. Analysis using circularly polarized light indicated a significantly reduced area fraction of collagen fibers in the peri‐implant epithelium of the WE group, as well as in the oral epithelium of the splinted zone.ConclusionA wide emergence angle of implant prostheses can compromise connective tissue attachment, hinder the formation of an adequate soft tissue seal, and potentially lead to marked bone remodeling.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"55 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144905847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Performance of Immediately Restored, Surface Modified Two‐Piece Zirconia Implants. A Prospective Case Series","authors":"G. Trimpou, A. Begić, K. Obreja, A. Montada, P. Parvini, F. Schwarz","doi":"10.1111/clr.70034","DOIUrl":"https://doi.org/10.1111/clr.70034","url":null,"abstract":"PurposeTo evaluate the short‐term success and survival rates of immediately restored surface modified two‐piece zirconia implants (CL).Material and MethodsA total of 23 patients had received CL implants (<jats:italic>n</jats:italic> = 26) for single‐tooth replacements in the anterior and posterior maxilla and mandible at healed extraction sites. Immediate implant restoration was accomplished if an insertion torque ≥ 30 Ncm was reached (Type 3–4 A protocol). Final occlusally screw‐retained crowns were provided after 3 months of healing.Implant survival and success (i.e., bleeding on probing—BOP, probing pocket depth—PD, mucosal recession—MR) were assessed at 6 and 12 months following final restoration.Patient‐reported outcomes were evaluated at 6 and 12 months.ResultsFive implants (<jats:italic>n</jats:italic> = 5 patients) could not be immediately restored, and four implants were lost during follow‐up. The survival rates amounted to 80%. For the final analysis, 16 patients with a total of 16 implants were evaluated. Minor changes to baseline (final restoration) were noted at 6 and 12 months for mean BOP (−3.3% ± 13.14%; 8.3% ± 16.9%), PD (−0.15 ± 0.48 mm; 0.08 ± 0.48 mm), and MR (0.0 ± 0.0 mm; 0.0 ± 0.0 mm) values. Mechanical and technical complications were not observed. Patients expressed an overall high satisfaction at 6 and 12 months.ConclusionsThe presented immediate restoration protocol may be associated with an increased risk for early implant losses.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"23 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144910960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Micro/Nano‐Roughened Self‐Glazed Zirconia Implant With Enhanced Osseointegration and Satisfactory Soft Tissue Sealing: An In Vitro and In Vivo Study","authors":"Minghao Zuo, Heng Zhang, Jialu Lv, Yanyan Zhou, Zhijian Xie, Yiqun Zhou","doi":"10.1111/clr.70021","DOIUrl":"https://doi.org/10.1111/clr.70021","url":null,"abstract":"ObjectivesThis study aimed to develop a novel self‐glazed zirconia (SZr) dental implant featuring micro/nano‐roughened thread and polished neck, and to examine its properties both in vitro and in vivo.Material and MethodsThe micro/nano‐roughened SZr surfaces (SZr‐MN) were manufactured using sandblasting and chemical vapor deposition. Surface topography, elemental composition, roughness, and contact angle were systematically characterized. <jats:styled-content style=\"fixed-case\"><jats:italic>Streptococcus mutans</jats:italic></jats:styled-content> and <jats:styled-content style=\"fixed-case\"><jats:italic>Porphyromonas gingivalis</jats:italic></jats:styled-content> were used to evaluate bacterial adhesion. Bone marrow mesenchymal stem cells (BMSCs) and human immortalized keratinocytes were used to assess cell adhesion, proliferation, and osteogenic differentiation. The sandblasting large‐grit acid‐etching treated titanium (Ti) surfaces (Ti‐SLA) served as the control. Ti and SZr implants were inserted into the mandibles of Beagle dogs, followed by radiological, fluorescent, and histomorphometric analyses after 8 and 12 weeks of healing.ResultsThe SZr‐MN surface exhibited micro‐scale ravines and gullies densely covered with curled, sheet‐like nano‐structures, which led to suitable roughness and improved hydrophilicity. Compared to the Ti‐SLA surface, the SZr‐MN surface demonstrated significantly reduced bacterial adhesion, along with increased adhesion and osteogenic differentiation of BMSCs. Consequently, the SZr implant achieved more extensive and denser surrounding bone tissue and enhanced osseointegration compared to the Ti implant, while both showed comparable dimensions of peri‐implant soft and hard tissues.ConclusionsThe novel SZr implant surfaces demonstrated excellent antibacterial activity, biocompatibility, and proosteogenic effect, leading to enhanced osseointegration and satisfactory soft tissue sealing. Our findings offer a unique perspective on improving the biological activity of zirconia dental implants.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"7 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Auxiliary Occlussal Devices on the Occlusal Accuracy of Multiple Implant‐Supported Restorations Fabricated Using Digital Workflow: A Randomized Control Trial","authors":"Yifan Zhang, Donghao Wei, Xi Jiang, Ping Di, Shuxin Ren","doi":"10.1111/clr.70029","DOIUrl":"https://doi.org/10.1111/clr.70029","url":null,"abstract":"ObjectiveThis study aimed to evaluate the effectiveness of auxiliary occlusal devices (AODs) in improving occlusal accuracy and reducing clinical adjustments in a fully digital workflow for multiple (3 or more) implant‐supported single crowns.Materials and MethodsTwenty‐nine patients with a total of 106 implant‐supported single crowns were enrolled. Participants were randomly assigned to either the test group (with AODs) or the control group (without AODs). Both groups underwent a digital workflow, and the morphology of restorations was recorded before and after occlusal adjustment using an intra‐oral scanner. Quantitative occlusal modifications, including grinding and porcelain additions, were calculated by 3D analysis software, and crown remake (occlusal deficiency &gt; 0.5 mm) was documented. Statistical analysis included the Mann–Whitney U test, Fisher's exact test, and generalized linear mixed model to assess the effects of group assignment, edentulous position, and their interaction on the amount of occlusal adjustment.ResultsThe test group exhibited significantly lower rates of porcelain addition (16.4% vs. 26.3%, <jats:italic>p</jats:italic> = 0.051) and crown remake (3.8% vs. 20.4%, <jats:italic>p</jats:italic> = 0.015) compared to the control group. The absolute amount of occlusal modification was significantly reduced in the AOD group (median 0.3290 mm) compared to the control (median 0.5273 mm, <jats:italic>p</jats:italic> = 0.001). Notably, free‐end saddle crowns showed a higher incidence of occlusal porcelain addition (<jats:italic>p</jats:italic> = 0.022), but the use of AODs in these cases significantly mitigated the need for adjustments (<jats:italic>p</jats:italic> = 0.007).ConclusionThe incorporation of AODs in a digital workflow significantly improves the precision of occlusal registration and reduces chairside modifications and remakes. AODs are especially beneficial in complex cases such as free‐end saddles and should be considered a valuable adjunct in digital implant prosthodontics.Trial RegistrationThis study was registered on the Chinese Clinical Trial Registry (<jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"https://www.chictr.org.cn/\">https://www.chictr.org.cn/</jats:ext-link>; ChiCTR2200064819)","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"38 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Relationship Between Intake of Proton Pump Inhibitors and Peri‐Implant Bone Microstructure by Using Fractal Analysis: A Retrospective Case–Control Study","authors":"Senem Reyhan Urcan, Alican Kuran, Deniz Akın Ankaralı, Umut Seki, Fatih Mehmet Coşkunses, Berkay Tokuc","doi":"10.1111/clr.70032","DOIUrl":"https://doi.org/10.1111/clr.70032","url":null,"abstract":"ObjectivesProton pump inhibitors (PPIs) have been suggested to influence bone metabolism and osseointegration. This study aimed to assess the long‐term effects of PPI usage on trabecular bone patterns around dental implants through fractal analysis of periapical radiographs.Material and MethodsThis retrospective, matched case–control study analyzed a database of 27 PPI users (87 dental implants) and established a control group of 27 nonusers (88 dental implants), matching them by age, sex, smoking status, total follow‐up duration, and history of augmentation procedures. The final study population included 54 patients with a total of 175 dental implants, all of which were from the same brand and identical in composition and surface treatment. The primary predictor variable was PPI use, while the outcome measures included implant survival rate, crestal bone loss (CBL), and fractal dimension (FD) values assessed on periapical radiographs.ResultsThree PPI users experienced implant failure during a mean follow‐up period of 76.9 months, whereas no failures occurred in the nonuser group (<jats:italic>p</jats:italic> &gt; 0.05). Similarly, no significant differences were observed in CBL values between the two groups (<jats:italic>p</jats:italic> &gt; 0.05). However, the mean (standard deviation) FD values at the final follow‐up were 1.14 (0.07) for PPI users and 1.19 (0.05) for nonusers, showing a significant difference (<jats:italic>p</jats:italic> &lt; 0.01).ConclusionsThe findings of this study suggest that PPI use may have a detrimental impact on bone metabolism surrounding dental implants. Clinicians should be vigilant regarding possible trabecular alterations in the jawbones of patients undergoing PPI therapy.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"50 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In Vitro Assessment of a Novel Piranha‐Passivated Dental Implant Surface Against Oral Biofilm Formation","authors":"Paula Nuevo, Leire Virto, Honorato Ribeiro‐Vidal, Javier Gil, Mariano Sanz","doi":"10.1111/clr.70031","DOIUrl":"https://doi.org/10.1111/clr.70031","url":null,"abstract":"Background and ObjectivesPeri‐implantitis, a significant complication resulting from bacterial colonization on dental implants, presents a challenge in oral healthcare. Developing surfaces that inhibit bacterial adhesion while promoting tissue integration is crucial for improving implant outcomes. This study aims to evaluate bacterial colonization on a novel passivated surface for dental implants using an in vitro multispecies biofilm model.Materials and MethodsThree types of titanium implants (standard, citric acid‐passivated, and piranha‐passivated) were characterized by analyzing roughness, contact angle values, and surface energy after the passivation treatments. The capacity for biofilm formation on these implants was evaluated using quantitative polymerase chain reaction (qPCR), scanning electron microscopy (SEM), and confocal laser scanning microscopy (CLSM). Bacterial colonization and viability were assessed at 6, 12, and 24 h. In addition, the protein adsorption capacity of these surfaces was determined.ResultsTreatments increased hydrophilicity and polar surface energy, with no change in roughness. Although no statistically significant differences were found, a slightly lower concentration of primary and intermediate colonizers was observed on piranha‐treated surfaces compared to citric acid implants, particularly during the 24‐h incubation period. CLSM analyses revealed a higher percentage of dead bacteria on piranha‐passivated implants over time. Piranha passivation also resulted in the lowest fibrinogen adsorption.ConclusionThese findings suggest that piranha passivation may be a promising treatment for dental implant surfaces, potentially reducing the risk of peri‐implantitis. However, the inherent limitations of the in vitro approach necessitate further clinical trials to validate the efficacy of this surface modification in real‐world clinical settings.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"107 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899288","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone Augmentation of Atrophic Alveolar Ridges Using a Synthetic Bone Substitute With Mesenchymal Stem Cells: A Randomized, Controlled Clinical Trial","authors":"Mariano Sanz, Cecilie Gjerde, Bjørn Tore Gjertsen, Alberto Ortiz‐Vigón, Nerea Sanchez, Alain Hoornaert, Jordi Caballe‐Serrano, Maria Giralt‐Hernando, Frederick Gaultier, Nicoleta Reinald, Else Marie Pinholt, Markus Rojewski, Helen Rouard, Nathalie Chevallier, Samih Mohamed‐Ahmed, Xieqi Shi, Tie‐Jun Shi, Hubert Schrezenmeier, Pierre Layrolle, Kamal Mustafa","doi":"10.1111/clr.70025","DOIUrl":"https://doi.org/10.1111/clr.70025","url":null,"abstract":"ObjectivesTo assess the efficacy and safety of a cell‐based therapy for 3D bone augmentation of severe alveolar bone defects prior to dental implant placement.Materials and MethodsA Phase 2 randomized controlled clinical trial evaluated the safety and efficacy of a cell therapy using expanded autologous iliac crest‐derived mesenchymal cells seeded on a synthetic bioabsorbable bone substitute covered with a non‐resorbable membrane. The control group received an autogenous bone block graft. After 5 months, CBCT scans were compared to measure the bone volume changes achieved after the regenerative surgery. Subsequently, dental implants were placed in the regenerated areas.ResultsA total of 48 patients were included and randomized (36 patients in the test group and 12 in the control group). However, seven patients did not reach the minimum required number of expanded MSCs and were therefore unable to be treated. The tested intervention demonstrated significantly greater gains in bone volume, with a mean difference of 480.01 mm<jats:sup>3</jats:sup> (<jats:italic>p</jats:italic> = 0.032). Similarly, the mean change in bone crest volume from baseline to 5 months was notably higher in the test group (1066.91 mm<jats:sup>3</jats:sup>) compared to the control group (586.9 mm<jats:sup>3</jats:sup>). Adverse reactions and patient morbidity were minor in both groups. Implants were placed on the regenerated bone, and all were integrated successfully in both groups.ConclusionsThe cell‐based therapy resulted in significant changes in bone volume compared to the control treatment, enabling dental implants in all patients. The procedure was associated with minimal adverse effects and patient morbidity.Trial Registration<jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"http://clinicaltrials.gov\">ClinicalTrials.gov</jats:ext-link>: NCT03373052, NCT04297813","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"15 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of a Gel Loaded With M101 on Bone and Peri‐Implantitis Healing: An Experimental In Vivo Study","authors":"Céline Stutz, Catherine Petit, Pierre‐Yves Gegout, Camille Le Gall, Maria Permuy, Mónica López‐Peña, Fernando Muñoz, Mario García González, Bénédicte Puissant, Yves Renaudineau, Franck Zal, Elisabeth Leize‐Zal, Olivier Huck","doi":"10.1111/clr.70022","DOIUrl":"https://doi.org/10.1111/clr.70022","url":null,"abstract":"ObjectivesThe aim of this study was to evaluate the effect of M101 gel in bone and peri‐implantitis healing and its safety of use.Materials and MethodsM101 gel and solution (1 g/L) were evaluated in four different models: (i) human osteoblast culture; (ii) mouse calvarial defect; (iii) extraction model in dogs; (iv) peri‐implantitis model in dogs. M101 cytocompatibility was evaluated in osteoblasts, and expression of ALP, Runx2, and BMP‐2 was determined. Calvarial defect was induced in mice by bone drilling, and healing was evaluated after 5 weeks. In dogs, peri‐implantitis was treated by non‐surgical and surgical approaches with or without M101 gel application. Analyses were performed after 2 months. Socket healing was evaluated by micro‐CT after tooth extraction. Local and systemic responses were evaluated after gel administration and intravenous injection.ResultsThe cytocompatibility of M101 was confirmed in osteoblasts, and ALP, Runx2, and BMP‐2 gene expression was increased after exposure (<jats:italic>p</jats:italic> &lt; 0.05). In mice, calvarial bone defect healing was 1.6 folds more in the M101 gel treated group than in the untreated group (<jats:italic>p</jats:italic> &lt; 0.001). In the extraction model, the local M101 gel application and systemic M101 administration did not induce an immunological response. In the peri‐implantitis dog model, M101 gel as an adjuvant to non‐surgical treatment led to improved PiPD reduction (<jats:italic>p</jats:italic> &lt; 0.05) when compared to non‐surgical treatment without M101 gel. No difference was observed when used as an adjunct to surgical treatment.ConclusionM101 may be a safe and interesting candidate as an adjuvant to improve bone healing and non‐surgical treatment in peri‐implantitis.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"25 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}