Clinical Oral Implants Research最新文献

{"title":"Influence of Implant Component Materials on Peri-Implant Soft Tissue Healing: A Comparative Histological and Immunohistochemical Study in Humans.","authors":"Lemmy Liegeois, Manon Borie, Geoffrey Lecloux, Dorien Van Hede, France Lambert","doi":"10.1111/clr.14391","DOIUrl":"https://doi.org/10.1111/clr.14391","url":null,"abstract":"<p><strong>Background: </strong>Recently, the importance of peri-implant soft tissue integration quality has been recognised as an essential factor in the long-term success of dental implant rehabilitation.</p><p><strong>Aim: </strong>The aim of this study was to explore the influence of three materials commonly used in implant dentistry, namely titanium (Ti), dental adhesive resin (Re) and polyetheretherketone (PEEK), on the peri-implant soft tissues.</p><p><strong>Methods: </strong>In this clinical randomised comparative study, 37 bone-level implants were placed, and experimental transmucosal healing abutments made of different materials were randomly assigned to each implant. These abutments were removed together with the surrounding soft tissues after 8 weeks. Immunohistochemical analyses were performed to determine the presence and localisation of different immune cells. In addition, clinical and radiographic data were collected and peri-implant bone remodeling was assessed.</p><p><strong>Results: </strong>Compared to the Ti and PEEK groups, Re abutments revealed a higher infiltration of macrophages in the connective tissue (p = 0.04) and neutrophils in the adjacent epithelium (p = 0.03). In the Re abutments, peri-implant bone remodeling was higher compared to the other groups (p = 0.01).</p><p><strong>Conclusion: </strong>The use of resin material as a transmucosal healing abutment should be carefully considered as it was associated with a higher presence of inflammatory cells at 8 weeks post-implantation as well as superior bone remodeling compared to PEEK and Ti.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142827570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Primary Stability of Dental Implants in Human Jawbones: Experiments & FE Analyses.","authors":"Patrik Wili, Cedric Rauber, Amal Saade, Salomé Bliggenstorfer, Valentina Ramirez-Garmendia, Ramon Schweizer, Ainara Irastorza-Landa, Vivianne Chappuis, Philippe Zysset","doi":"10.1111/clr.14386","DOIUrl":"https://doi.org/10.1111/clr.14386","url":null,"abstract":"<p><strong>Objectives: </strong>Primary stability (PS) is a key factor for promoting osseointegration and long-term success of dental implants particularly for immediate loading protocols. Beyond the current assessments of PS, an accurate pre-operative evaluation of PS would contribute to the improvement of surgical planning and treatment outcome. This study used biomechanical testing and homogenized finite element (hFE) analysis to objectively measure PS in the laboratory, and digitally estimate PS from prior μCT reconstructions.</p><p><strong>Material and methods: </strong>Thirty-five bone samples extracted from the jaws of two donors were examined. Twenty-two were finally evaluated for PS. After scanning of the samples with μCT, implants were inserted by two experienced surgeons, and various metrics such as μCT-based bone volume fraction (BV/TV), insertion torque (IT), and resonance frequency analysis (RFA) were assessed to determine PS. Mechanical tests were conducted to measure ultimate force (UFexp) as an objective indicator of PS while the hFE simulations were performed to estimate this same ultimate force (UFsim).</p><p><strong>Results: </strong>Higher correlation was found between UFsim and UFexp (R² = 0.85) than between BV/TV and UFexp (R² = 0.61), IT and UFexp (R² = 0.50), and RFA and UFexp (R² = 0.38). All variables demonstrated a statistically significant linear correlation with UFexp (p < 0.01).</p><p><strong>Conclusion: </strong>UFsim turns out to be a more reliable and objective indicator of PS than IT and RFA. The hFE analysis requires prior μCT reconstructions and is currently limited by numerical convergence problems. Despite these limitations, pre-operative hFE analysis emerges as a promising tool with a higher accuracy for estimation of PS than state of care techniques.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142817427","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Performance of the Implant Disease Risk Assessment in Predicting Peri‐Implantitis: A Retrospective Study","authors":"Nathalia Vilela, Bruno C. V. Gurgel, Christina M. Rostant, Karin C. Schey, Krishna Mukesh Vekariya, Hélio D. P. da Silva, Claudio M. Pannuti, Poliana M. Duarte","doi":"10.1111/clr.14390","DOIUrl":"https://doi.org/10.1111/clr.14390","url":null,"abstract":"ObjectiveThis university‐based retrospective study aimed to assess the performance of the implant disease risk assessment (IDRA) in predicting peri‐implantitis.Material and MethodsPatients with implants loaded for at least 1 year were included. Peri‐implantitis development was the outcome, while the IDRA score and its eight vectors were the predictors. The IDRA score was calculated using an online tool. Data were analyzed using Cox proportional hazards models and ROC curve (AUC).ResultsAmong 480 implants in 235 patients, 7.9% of implants and 9.4% of patients developed peri‐implantitis. Implants at high risk for the “number of sites with PD ≥ 5 mm” vector had an increased risk (HR = 9.8, <jats:italic>p</jats:italic> = 0.004) of peri‐implantitis, compared to those at low risk for this parameter. Implants at moderate (HR = 4.8, <jats:italic>p</jats:italic> = 0.04) and high (HR = 10.0, <jats:italic>p</jats:italic> = 0.01) risk for the “distance from the restorative margin (RM) to bone crest (BC)” vector exhibited a higher risk of peri‐implantitis than implants at low risk for this parameter. The IDRA tool demonstrated an AUC of 0.66 (sensitivity = 0.80; specificity = 0.24) when estimated at implant level and an AUC of 0.61 (sensitivity = 0.91; specificity = 0.32) when calculated at patient level. The mixed‐effects Cox model did not reveal a significant association between the overall IDRA score and the development of peri‐implantitis (HR = 7.2, <jats:italic>p</jats:italic> = 0.18).ConclusionIDRA demonstrates good sensitivity but low specificity and suboptimal discriminatory capacity in predicting peri‐implantitis. The “number of sites with PD ≥ 5 mm” and “distance from RM to BC” emerged as the most effective predictors for peri‐implantitis.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"19 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-12-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142796938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Use of the Facial Sinus Wall as Bone Shell Onlay Graft for Maxillary Posterior Ridge Reconstruction: A Retrospective Case Series.","authors":"Stefan Krennmair, Michael Weinländer, Michael Malek, Thomas Forstner, Michael Stimmelmayr, Gerald Krennmair","doi":"10.1111/clr.14387","DOIUrl":"https://doi.org/10.1111/clr.14387","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the performance and clinical outcome of vertical and horizontal bone augmentation (VHBA) in posterior maxillary regions combining lateral window sinus floor elevation (LWSFE) with a horizontal bone shell technique applying the maxillary facial sinus wall as a bone plate.</p><p><strong>Materials and methods: </strong>In 18 patients, LWSFE was combined with a horizontal bone shield augmentation procedure utilizing the maxillary facial sinus bone wall as a lateral bone plate. Both the sinus cavity and the lateral bone box created were grafted with a mixture of autogenous bone/venous blood and bovine bone mineral. The primary aim was to assess the performance of combined techniques enabling subsequent implant placement. Using radiographic measurements (preoperative, after VHBA, at implant placement, and at follow-up), bone gain/reduction of augmented horizontal ridge width (HRW) and vertical bone height (VBH) were evaluated. Additionally, clinical outcome assessing implant survival/success rate, marginal bone loss (MBL), and implant health (mucositis/peri-implantitis) was evaluated.</p><p><strong>Results: </strong>For the combined VHBA techniques, HRW and VBH increased significantly (p < 0.001) from preoperative 3.5 ± 1.4 mm/3.6 ± 2.1 mm to 9.7 ± 1.9 mm/18.0 ± 1.6 mm post-augmentation. However, HRW and VBH dimensions decreased up to 8.9 ± 1.8 mm/17.1 ± 1.4 mm at implant placement and 8.6 ± 1.7 mm/16.7 ± 1.3 mm at follow-up evaluation (3.8 ± 1.8 years; p < 0.001, respectively). Augmented bone reduction was significantly higher (-7.7%) between the augmentation procedure and implant placement than in the post-implant-placement period (-2.5%). All implants survived (100%) representing peri-implant MBL of -0.9 ± 0.7 mm, pocket depth of 3.4 + 1.8 mm, and prevalences of 5%/0% for peri-implant mucositis/peri-implantitis.</p><p><strong>Conclusion: </strong>The combination of horizontal bone augmentation using local bone shield transfer from the maxillary facial sinus wall with LWSFE enables sufficient reconstruction of maxillary posterior ridge.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-12-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794001","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of CAD/CAM Abutment Morphology on the Outcomes of Implant Therapy: A Randomized Controlled Trial.","authors":"Christopher A Barwacz, Madeline Swenson, Emilio Couso-Queiruga, Carissa Comnick, Xian Jin Xie, Gustavo Avila-Ortiz","doi":"10.1111/clr.14389","DOIUrl":"https://doi.org/10.1111/clr.14389","url":null,"abstract":"<p><strong>Objectives: </strong>Variations in transmucosal abutment contour design may affect the outcomes of implant therapy. This randomized controlled trial was primarily aimed at testing the effect that CAD/CAM zirconia abutments with either a concave or linear divergent transmucosal morphology have on peri-implant mucosal dynamics and indicators of peri-implant health at 1 year after final implant-supported prosthesis insertion in the anterior maxilla.</p><p><strong>Materials and methods: </strong>Following computer-guided implant placement and osseointegration, eligible subjects were randomized into either the experimental (concave morphology) or the control (linear divergent morphology) group. A comprehensive set of outcomes of interest related to peri-implant soft tissue dynamics, phenotypical features, and indicators of peri-implant health were assessed at different time points over a 1-year period after insertion of the final restoration.</p><p><strong>Results: </strong>Out of 60 initially recruited subjects, a total of 54 completed the study (n = 29 in the experimental group concave/n = 25 in the control group). Overall implant survival and restoration rates between master impression and 12 months were 100% and 98.2%, respectively. Although a trend for coronal migration of the buccal mucosa zenith, gain in mucosal thickness, and increased probing depth and bleeding on probing was observed in both groups, these changes were clinically negligible, and no substantial differences were observed between study groups regardless of variations in transmucosal abutment morphology.</p><p><strong>Conclusion: </strong>The use of either linear divergent or concave custom CAD/CAM zirconia abutments in a screw-retained, delayed loading approach yielded no significant differences.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implant-Supported Cantilever Fixed Dental Prosthesis in the Anterior Region: Effect of Implant Type and Aging In Vitro.","authors":"Nadja Rohr, Yotaro Iwauchi, Raffael Bernauer, Raphael Heuzeroth, Nicola U Zitzmann","doi":"10.1111/clr.14388","DOIUrl":"https://doi.org/10.1111/clr.14388","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate if the fracture load of implant-supported cantilever fixed dental prostheses (ICFDPs) in the anterior region is affected by the implant type and the aging protocol.</p><p><strong>Materials and methods: </strong>Sixty ICFDPs were prepared using multilayer monolithic zirconia for restoring bone-level (BL) and tissue-level (TL) titanium-zirconium implants. Fracture load was measured at baseline (no aging) or after aging in a chewing simulator loading the implant crown or the cantilever in a 30° angle (n = 10 per group). A two-way ANOVA was applied (α = 0.05) for the effects of implant type and aging protocol.</p><p><strong>Results: </strong>Implant type (p < 0.001) and aging (p < 0.001) had a significant effect on fracture load values. Baseline specimens of both BL (665 ± 62 N) and TL (554 ± 23 N) had significantly higher mean fracture load values than those of aged specimens(BL implant crown 545 ± 46 N, BL cantilever 563 ± 45 N, TL implant crown 455 ± 32 N, TL cantilever 476 ± 24 N) (p < 0.001). The loading position during aging did not affect fracture load values for BL (p = 0.980) nor TL (p = 0.749). BL implants failed by cement fracture and abutment deformation, while for TL the transmucosal part of the implant deformed.</p><p><strong>Conclusions: </strong>The fracture load values of anterior ICFDPs decrease with aging in a chewing simulator. BL implants are preferable over TL implants for anterior ICFDPs as higher fracture load values were achieved, and no implant deformation occurred.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142754787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 10-Year Follow-Up of Reconstructive Treatment of Peri-Implantitis Using Mineralized Dehydrated Allograft and Resorbable Membrane: A Retrospective Case Series.","authors":"Gerardo La Monaca, Nicola Pranno, Susanna Annibali, Antonella Polimeni, Maria Paola Cristalli","doi":"10.1111/clr.14385","DOIUrl":"https://doi.org/10.1111/clr.14385","url":null,"abstract":"<p><strong>Objectives: </strong>To evaluate the 10-year clinical and radiographic outcomes of peri-implantitis intrabony defects treated with mineralized dehydrated bone allograft (MDBA) and resorbable membrane in patients undergoing a regular supportive peri-implant/periodontal therapy (STP).</p><p><strong>Materials and methods: </strong>The original study participants were 34 (34 defects). After mechanical debridement and chemical decontamination of implant surfaces, intrabony defects were filled with MDBA and covered by a resorbable membrane. Patients were enrolled in a maintenance program with a recall interval of 6 months. The primary outcome was the absence of additional marginal peri-implant bone loss ≥ 1.0 mm after surgery. The composite outcome was no additional marginal peri-implant bone loss ≥ 1.0 mm and the absence of probing depth (PD) ≥ 5 mm, bleeding on probing and suppuration.</p><p><strong>Results: </strong>Of the original 34 implants, 20 completed the 10-year follow-up, and three failed. Related to the primary outcome, the mean peri-implant marginal bone level changed from 4.78 mm (SD 1.84) at baseline to 3.10 mm (SD 1.73) after surgery and 3.71 mm (SD 1.78) at the follow-up end point. According to the composite outcome for disease resolution, 19 of the 34 original implants were successfully treated at the 10-year follow-up with a statistically significant difference between 1 (31/34 implants) and 5 years (20/34 implants) (p = 0.003) and 1 and 10 years (p = 0.001) but not between 5 and 10 years (p = 1.000).</p><p><strong>Conclusions: </strong>Ten years after the reconstructive treatment, followed by regular SPT, the cumulative successful treatment rate, according to the primary and the composite outcomes, was 58% (20/34 implants) and 53% (19/34) implants, respectively.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142750193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fixed Full‐Arch Maxillary Prostheses Supported by Four Versus Six Implants: 5‐Year Results of a Multicenter Randomized Clinical Trial","authors":"Marco Toia, Cristiano S. Moreira, Debora R. Dias, Enrico Corrà, Andrea Ravidà, Denis Cecchinato","doi":"10.1111/clr.14383","DOIUrl":"https://doi.org/10.1111/clr.14383","url":null,"abstract":"ObjectivesThis 5‐year multicenter randomized clinical trial assessed the non‐inferiority of maxillary implant‐supported fixed complete dentures (FCDs) with four (4‐I) compared to six implants (6‐I) in terms of radiographic marginal bone level (MBL) changes after 5 years in function.Materials and MethodsIndividuals were randomly assigned to the 4‐I or 6‐I groups. Follow‐ups occurred at 1, 3, and 5 years. At each visit, FCDs were unscrewed, clinical parameters (plaque index, bleeding on probing, pocket depth, and keratinized mucosa width) were recorded using a periodontal probe, periapical radiographs were obtained, and maintenance care was performed. MBL changes, incidence of techincal, prosthetic, and biological complications, treatments costs, and satisfaction were evaluated.ResultsOf 47 patients rehabiliated with 233 implants, survival rates were 99.3% for 6‐I and 100% for 4‐I (one early failure; 6‐I group). No significant MBL differences were observed at 5 years between and within the groups. Both groups showed a decrease in keratinized mucosa width and experienced prosthetic and biological complications, but no peri‐implantitis. The 4‐I exhibited a significantly higher incidence of technical complications (16.6% vs. 0%) Cost analysis favored 4‐I for initial and total costs. Clinician and patient satisfaction varied, with 4‐I preferred aesthetically and 6‐I functionally, particularly in speaking ability at earlier follow‐ups.ConclusionThe use of FCDs supported by four implants is non‐inferior to six implants in terms of radiographic MBL changes after 5 years in function. Both groups demonstrated comparable survival rates and incidence of biological and prosthetic complications. The 4‐I was associated with higher technical complications and reduced overall treatment cost.Trial Registration<jats:ext-link xmlns:xlink=\"http://www.w3.org/1999/xlink\" xlink:href=\"https://register.clinicaltrials.gov/\">ClinicalTrials.gov identifier</jats:ext-link>: NCT02405169","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"13 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-11-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142697130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective Clinical Study on the Accuracy of Static Computer-Assisted Implant Surgery in Patients With Distal Free-End Implants. Conventional Versus CAD-CAM Surgical Guides.","authors":"García-Mira Berta, Canullo Luigi, Peñarrocha-Diago Miguel, Balaguer-Martí José Carlos","doi":"10.1111/clr.14384","DOIUrl":"https://doi.org/10.1111/clr.14384","url":null,"abstract":"<p><strong>Objectives: </strong>To compare the accuracy of CAD-CAM and conventional guides in the static computer-assisted implant surgery (sCAIS) placement of distal free-end implants.</p><p><strong>Material and methods: </strong>A prospective, controlled, and blinded quasi-experimental study was done involving 27 patients (76 implants) distributed into two groups according to the surgical guide manufacturing approach used: conventional (control group [CG]) or CAD-CAM (test group [TG]). The implants were planned in the software and the surgical guides were manufactured. Fully guided implant placement was carried out and the deviations were measured along with secondary variables as potential confounding factors. Descriptive analyses were performed on mean, standard deviation (SD), and interquartile range (IQR). In the comparative/inferential analysis hypothesis, contrasts were made of the quantitative and qualitative variables and multiple linear models were generated to adjust for the different confounding variables recorded.</p><p><strong>Results: </strong>Coronal horizontal deviation (CHD) was significantly greater in CG (1.52 mm) versus TG (1.04 mm) (p = 0.004). Apical horizontal deviation (AHD) in turn was 1.67 versus 1.46 mm, respectively; angular deviation was 2.87 versus 3.64; and vertical deviation was -0.1 versus -0.05 mm, with no significant differences between the groups (p > 0.05). A greater sleeve height, positioning in premolars versus molars, and the use of shorter implants, were associated with greater accuracy in relation to CHD and/or AHD (p < 0.05). The implant success rate at 1 year was 92.1%, 90.7% in TG, and 100% in CG, being statistically significant (p = 0.026) at the implant level, but not significant at the patient level.</p><p><strong>Conclusions: </strong>The CAD-CAM surgical guides proved to be more accurate than the conventional guides in the sCAIS placement of distal free-end implants, with statistically significant differences being observed in terms of CHD. All implant failures occurred in TG (6 implants/3 patients).</p><p><strong>Trial registration: </strong>ClinicalTrials.gov identifier: NCT06404385.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142692711","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Regeneration of Chronic Alveolar Vertical Defects Using a Micro Dosage of rhBMP-2. An Experimental In Vivo Study.","authors":"Istvan A Urban, Sándor Farkasdi, Dieter D Bosshardt, Mauricio G Araujo, Andrea Ravidà, Kathrin Becker, Robert Kerberger, Hom-Lay Wang, Ulf M E Wikesjö, Gabor Varga, Muhammad H A Saleh","doi":"10.1111/clr.14379","DOIUrl":"https://doi.org/10.1111/clr.14379","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study is to compare the effect of the location of recombinant human bone morphogenetic protein 2 (rhBMP-2) from the native bone and the periosteum for vertical alveolar bone augmentation.</p><p><strong>Materials and methods: </strong>Mandibular, chronic, standardized, bilateral, and vertical defects in 12 beagle dogs were evaluated using four modalities: a xenograft alone (XENO; n = 6); rhBMP-2 alone (BMP; n = 6); a technique with rhBMP-2 close to the host bone covered by xenograft (SAN; n = 6); and a technique with rhBMP-2 close to the flap on top of the xenograft (LAS; n = 6). After 8 weeks, a series of in vivo inspections, fluorescence microscopy, histologic and histomorphometric evaluations, and micro-CT analyses.</p><p><strong>Results: </strong>After 8 weeks of healing, new bone formation correlated with proximity of rhBMP to the perforated membrane with BMP and LAS (p = 0.024). The highest total bone volume was found in the LAS group (45.1% ± 13.3%), followed by the SAN group (35.2% ± 6.7%), BMP group (33.1% ± 11.8%), followed by the XENO group (23.1% ± 6.5%). The SAN group demonstrated frequent seroma formation. Blood vessel formation was more pronounced in the LAS + rhBMP group, with a significant increase of 27.1% compared to the XENO group (p = 0.02). Micro-CT revealed a strong trend for higher bone volume in the BMP group (34.7%) compared to the XENO group (13.6%) (p = 0.06). Only rhBMP-2 groups demonstrated bone formation above the perforated membrane.</p><p><strong>Conclusion: </strong>The location of rhBMP-2 in relation to the biomaterial and periosteum influenced the effectiveness of vertical bone regeneration.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}