Clinical Oral Implants Research最新文献

{"title":"Comparison Between Conventional and Artificial Intelligence-Assisted Setup for Digital Implant Planning: Accuracy, Time-Efficiency, and User Experience.","authors":"Panagiotis Ntovas, Laurent Marchand, Albrect Schnappauf, Matthew Finkelman, Marta Revilla-Leon, Wael Att","doi":"10.1111/clr.14382","DOIUrl":"10.1111/clr.14382","url":null,"abstract":"<p><strong>Objectives: </strong>To investigate the reliability and time efficiency of the conventional compared to the automatic artificial intelligence (AI) segmentation of the mandibular canal and registration of the CBCT with the model scan data, in relation to clinician's experience.</p><p><strong>Materials and methods: </strong>Twenty clinicians, 10 with a moderate and 10 with a high experience in computer-assisted implant planning, were asked to perform a bilateral localization of the mandibular canal, followed by a registration of the intraoral model scan with the CBCT. Subsequently, for each data set and each participant, the same operations were performed utilizing the AI tool. Statistical significance was assessed via a mixed model (using the PROC MIXED statement and the compound symmetry covariance structure).</p><p><strong>Results: </strong>The mean time for the segmentation of the mandibular canals and the registration of the models was 4.75 (2.03)min for the manual and 2.03 (0.36) min for the AI-automated operations (p < 0.001). The mean discrepancy in the mandibular canals was 0.71 (1.80) mm RMS error for the manual segmentation and 0.68 (0.36) RMS error for the AI-assisted segmentation (p > 0.05). For the registration between the CBCT and the intraoral scans, the mean discrepancy was 0.45 (0.16) mm for the manual and 0.37 (0.07) mm for the AI-assisted superimposition (p > 0.05).</p><p><strong>Conclusions: </strong>AI-automated implant planning tools are feasible options that can lead to a similar or better accuracy compared to the conventional manual workflow, providing improved time efficiency for both experienced and less experienced users. Further research including a variety of software and data sets is required to be able to generalize the outcomes of the present study.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142686267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Polydeoxyribonucleotide (PDRN) on Endosinus Bone Regeneration Following Sinus Floor Elevation: An Experimental In Vivo Pilot Study.","authors":"Hyunwoo Lim, Ji-Youn Hong, Seung-Il Shin, Jong-Hyuk Chung, Daniel S Thoma, Ronald E Jung, Hyun-Chang Lim","doi":"10.1111/clr.14378","DOIUrl":"https://doi.org/10.1111/clr.14378","url":null,"abstract":"<p><strong>Objective: </strong>To determine the effect of polydeoxyribonucleotide (PDRN) on endosinus bone regeneration in a rabbit sinus model at sequential healing time points.</p><p><strong>Materials and methods: </strong>Eighteen New Zealand white rabbits were used. Bilateral sinus floor elevation (SFE) was performed. Two groups were randomly assigned to each sinus: (1) test group, in which SFE was performed using collagenated bone substitute material soaked with PDRN (concentration 2.0 mg/mL, dose 0.5 mL), and (2) control group, in which SFE was performed using collagenated bone substitute material only. The experimental animals were sacrificed at 2, 4, and 8 weeks (n = 6 at each healing time point). Microcomputed tomography (micro-CT), histologic, and histomorphometric analyses were performed.</p><p><strong>Results: </strong>The micro-CT analysis revealed statistically significant increases in the mineralized tissue volume between 4 and 8 weeks (p < 0.05). Histologically, no specific intergroup difference was found in the pattern of new bone formation. Histomorphometrically, the area of newly formed bone (NB) was larger in the test group than in the control group at all healing time points (1.4 vs. 1.2 mm² at 2 weeks, 3.4 vs. 1.9 mm² at 4 weeks, and 5.7 vs. 4.5 mm² at 8 weeks; median value), but the difference was statistically significant only at 4 weeks (p < 0.05). NB in set regions of interest (ROI_C, ROI_W, and ROI_M) tended to be greater in the test group than in the control group without statistical significance (p > 0.05).</p><p><strong>Conclusions: </strong>PDRN appeared to enhance new bone formation at all healing time points, but the improvement was statistically significant only at 4 weeks.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675166","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Minocycline on Early Wound Healing after Implant Placement: An In Vitro and Randomized Clinical Study.","authors":"Yanjun Zhang, Xiaobo Duan, Fei Xue, Xinyi Zhou, Quan Yuan, Xingmei Yang","doi":"10.1111/clr.14380","DOIUrl":"https://doi.org/10.1111/clr.14380","url":null,"abstract":"<p><strong>Objective: </strong>To determine the in vitro effects of minocycline on human gingival fibroblasts (HGFs), its clinical impact on early wound healing after implant placement, and its potential mechanism of action.</p><p><strong>Methods: </strong>First, we evaluated the in vitro proliferation, migration, and collagen production of HGFs treated with different concentrations of minocycline, as well as the underlying mechanism. Subsequently, we conducted a clinical trial and randomly assigned 40 partially edentulous patients to either the test (minocycline hydrochloride treatment) or control (blank control) group immediately after implant surgery. The early wound healing score (EHS), pain index, gingival index (GI), modified sulcus bleeding index (mSBI), and peri-implant crevicular fluid samples were assessed or collected 3 and/or 7 days after surgery.</p><p><strong>Results: </strong>In vitro, 1 μg/mL minocycline promoted the proliferation, migration, and collagen production of HGFs. Minocycline inhibited collagen degradation by downregulating the expression of matrix metalloproteinase-2 (MMP-2) and MMP-14 and upregulating tissue inhibitors of metalloproteinases-2. However, higher concentrations of minocycline, 10 and 100 μg/mL, exhibited adverse effects. In the randomised clinical trial, the test group showed significantly better clinical outcomes compared to the control group, with higher EHS and lower GI, mSBI, concentrations of IL-1β, IL-10, and TNF-α, and relative abundance of Streptococcus and gram-negative anaerobic bacteria.</p><p><strong>Conclusions: </strong>Small doses of minocycline (1 μg/mL) promoted the proliferation and migration of HGFs and inhibited collagen degradation in vitro. Locally delivered minocycline after implant surgery improves clinical outcomes by promoting early wound healing, relieving the inflammatory response, and decreasing early colonisation of gram-negative anaerobic bacteria.</p><p><strong>Trial registration: </strong>This clinical trial was registered in the Chinese Clinical Trial Registry (registration number: ChiCTR2100044680).</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142675097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Metal Artifact Reduction Tool of Two Cone Beam CT on the Detection of Bone Graft Loss Around Titanium and Zirconium Implants-An Ex Vivo Diagnostic Accuracy Study.","authors":"Michelle Chang, Henrique Mateus Alves Felizardo, Christiano Oliveira-Santos, Hugo Gaêta-Araujo","doi":"10.1111/clr.14381","DOIUrl":"10.1111/clr.14381","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study is to investigate the influence of metal artifact reduction (MAR) on two cone beam computed tomography (CBCT) units in the evaluation of bone graft loss adjacent to titanium (Ti) and zirconium (Zr) implants.</p><p><strong>Material and methods: </strong>Twelve Ti and twelve Zr implants were placed in the posterior region of dry human mandibles. Bone graft was applied to the level of the cover screw. Bone graft loss was simulated in half of the sample (6 Ti and 6 Zr) by removing the graft material up to the third implant thread on the buccal surface. CBCT images were acquired on two units, varying the application of MAR (OP300-off and on; Eagle 3D-standard, intermediate, and extreme). The images were assessed by five evaluators that scored the presence of graft loss according to a 5-point scale. The diagnostic values were calculated and compared by non-parametric tests with a significance level of 5%.</p><p><strong>Results: </strong>Higher diagnostic values were achieved with MAR activated in the OP300 unit, for Ti and Zr (p < 0.05). On the Eagle 3D unit, MAR in extreme mode resulted in lower diagnostic values for both types of implants (p < 0.05). The diagnostic values of Ti implants were higher than Zr implants (p < 0.05).</p><p><strong>Conclusion: </strong>The application of MAR influences the diagnosis of bone graft loss adjacent to Ti and Zr dental implants. However, the extreme mode of MAR in the Eagle 3D unit can impair the diagnostic task in both types of implants and should be avoided.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Rehabilitation of Partially Edentulous Maxilla With Unilateral Zygomatic Implants: A Retrospective Study up to 23 Years Follow-Up.","authors":"Shengchi Fan, Ruben Davo, Bilal Al-Nawas, Eduard Valmaseda Castellón","doi":"10.1111/clr.14377","DOIUrl":"https://doi.org/10.1111/clr.14377","url":null,"abstract":"<p><strong>Objectives: </strong>This retrospective study aimed to evaluate the clinical outcomes associated with zygomatic implant (ZI) rehabilitation in partially atrophic edentulous maxillae over a mean follow-up period of more than 10.3 years.</p><p><strong>Methods: </strong>All consecutive patients underwent ZI rehabilitation between 1999 and 2020, with a minimum follow-up period of 3 years. The primary outcome was the implant survaival rate. Secondary outcomes included the prosthesis success rate, complications, and Oral Health-Related Quality of Life.</p><p><strong>Results: </strong>Of the 21 patients, treated with 27 ZIs and 48 conventional implants (CIs), 9 (42.9%) were females. The mean follow-up was 10.3 ± 5.7 years (range 3.2-23.4). ZI and CI survival rates were 100% and 97.9%, respectively, with one CI that failed. Eleven patients received 12 CIs placed in the pterygoid and tuberosity region. Most of the implants (81.33%) were immediately loaded, with 17 patients (80.9%) receiving 21 acrylic bridges. Of the total of 26 definitive prosthesis, the success rate was 96.1%. Local inflammation (n = 2) and soft tissue recession (n = 1) were reported as complications, occurring at a mean follow-up of 4.5 and 3.2 years, respectively. The mean score of the OHIP-14 questionnaire was 1.19 ± 1.99.</p><p><strong>Conclusions: </strong>Unilateral ZI rehabilitation was a predictable option for patients with partially atrophic edentulous maxilla who have experienced previous graft or implant failures, or who require immediate loading. Splinting the ZI with CI for restoration appeared to be essential in unilateral ZI treatment. Complications were infrequent and could be managed effectively, with patient-reported outcomes indicating normalization in quality of life.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142638614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Alveolar Ridge Regeneration With Open Versus Closed Healing in Damaged Extraction Sockets: A Preclinical In Vivo Study.","authors":"Jae-Won Choi, Jin-Young Park, Jae-Kook Cha, Pham-Duong Hieu, Hwi-Dong Jung, Chang-Sung Kim","doi":"10.1111/clr.14376","DOIUrl":"https://doi.org/10.1111/clr.14376","url":null,"abstract":"<p><strong>Objective: </strong>The objective of this study was to compare open versus closed healing of soft and hard tissue following alveolar ridge preservation (ARP) procedures in damaged extraction sockets.</p><p><strong>Materials and methods: </strong>ARP was performed in five mongrel dogs using collagenated deproteinized bovine bone mineral (cDBBM) and a resorbable non-cross-linked collagen membrane (NCCM) in damaged extraction sockets, with each socket entrance left either open (open group) or closed (closed group). Clinical wound epithelization at the socket entrance and the dimensions of keratinized tissue were evaluated over time. Additionally, the augmented ridge dimensions and new bone formation were assessed radiographically and histologically at 8 weeks after surgery.</p><p><strong>Results: </strong>The dimensions of the socket entrance gradually decreased in the open group, and wound epithelization was almost complete within 4 weeks. The mucogingival junction was maintained more apically in the open group than in the closed group (0.14 ± 0.40 mm vs. -0.86 ± 0.71 mm [mean ± SD], p < 0.05). The augmented ridge dimensions did not differ significantly between the open and closed groups (93.1% ± 5.4% vs. 88.3% ± 11.2%, p > 0.05). Histological analyses revealed no significant differences in the amount of newly formed bone. However, membrane resorption in the crestal region was more pronounced in the open group.</p><p><strong>Conclusion: </strong>Open and closed healing approaches for ARP in extraction sockets with damaged buccal wall resulted in similar ridge dimensions and new bone formation. However, there was less reduction of the buccal bone crest and wider keratinized tissue width after open healing.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":" ","pages":""},"PeriodicalIF":4.8,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142496365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Accuracy of Zygomatic Implant Placement Using Task‐Autonomous Robotic System or Dynamic Navigation: An In Vitro Study","authors":"Jinyan Chen, Baoxin Tao, Xinbo Yu, Yiqun Wu, Feng Wang","doi":"10.1111/clr.14373","DOIUrl":"https://doi.org/10.1111/clr.14373","url":null,"abstract":"ObjectivesTo evaluate and compare the accuracy of task‐autonomous robot‐assisted implant surgery (RAIS) and dynamic computer‐assisted implant surgery (dCAIS) for zygomatic implant placement.Materials and MethodsTen atrophic edentulous maxilla models requiring zygomatic implant (ZI) placement were randomly divided into the RAIS and dCAIS groups. Osteotomies and implant placement were performed under the guidance of a task‐autonomous robotic system or dynamic navigation system. A total of 20 ZIs were analyzed. The angular, coronal, lateral coronal, coronal depth, apical, lateral apical, and apical depth deviations were measured and analyzed between the two groups. The primary outcome parameters were the angular deviations between the planned and the placed ZIs. Data was subjected to descriptive and comparative statistical analysis. The significance of inter‐group differences for continuous variables was assessed with Student's two‐sample <jats:italic>t</jats:italic>‐tests, Welch two‐sample <jats:italic>t</jats:italic>‐tests, and Mann–Whitney <jats:italic>U</jats:italic> tests according to the distribution normality and variance homogeneity.ResultsZI placement deviations were compared between the RAIS and dCAIS groups, showing a mean angular deviation of 0.92 ± 0.40° versus 2.03 ± 0.53° (<jats:italic>p</jats:italic> &lt; 0.001), a mean (±SD) coronal deviation of 0.48 ± 0.25 mm versus 1.29 ± 0.46 mm (<jats:italic>p</jats:italic> &lt; 0.001), and a mean apical deviation of 0.88 ± 0.28 mm versus 1.96 ± 0.46 mm (<jats:italic>p</jats:italic> &lt; 0.001).ConclusionsFor computer‐guided ZI placement, task‐autonomous RAIS was superior to dCAIS in terms of accuracy.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"58 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142488807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A 10-year Retrospective Clinical Study to Identify Risk Indicators for Peri-Implant Bone Loss and Implant Failure.","authors":"Simon Windael,Bruno Collaert,Stefanie De Buyser,Stijn Vervaeke,Hugo De Bruyn","doi":"10.1111/clr.14375","DOIUrl":"https://doi.org/10.1111/clr.14375","url":null,"abstract":"AIMTo evaluate long-term survival and success of dental implants and evaluate indicators affecting the long-term outcome.MATERIALS AND METHODSImplant survival, success and crestal bone loss (BL) over time were evaluated. For covariates at patient level, Kaplan-Meier estimates of implant survival were compared between groups with the log-rank test. Observed mean bone loss (MBL) was plotted as a function of time. Cumulative frequencies of BL were plotted for different post-op times. Uni- and multivariate analysis was performed. Simple linear mixed and multiple linear mixed models for BL at 1, 5 and 10 years were fitted.RESULTS407 patients (221 women, 186 men; mean age 64.86 years (range 28-92, SD 10.11)), with 1482 implants, responded. Absolute implant survival was 94.74%; MBL was 0.81 mm (SD 1.58, range 0.00-17.00) after an average follow-up of 10.66 years (range 10-14, SD 0.87). Implant survival was influenced on implant level by smoking, implant width and early bone loss (EBL) > 0.5 mm; on patient level by a history of periodontitis. Indicators influencing MBL after the 1st year were abutment height, type of surgery and implant width, while after 5 and 10 years of function were abutment height, EBL > 0.5 mm and smoking.CONCLUSIONImplant survival was significantly affected by a history of periodontitis on patient level and by smoking, implant width and EBL > 0.5 mm on implant level. Late bone loss was significantly affected by abutment height, EBL > 0.5 mm and smoking.TRIAL REGISTRATIONB670201524796.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"9 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2024-10-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142488304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Oral Communication","authors":"","doi":"10.1111/clr.14365","DOIUrl":"10.1111/clr.14365","url":null,"abstract":"","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"35 S28","pages":"3-46"},"PeriodicalIF":4.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14365","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487561","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"e-Poster","authors":"","doi":"10.1111/clr.14366","DOIUrl":"10.1111/clr.14366","url":null,"abstract":"","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"35 S28","pages":"47-318"},"PeriodicalIF":4.8,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14366","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142487209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}