Clinical Oral Implants Research最新文献

{"title":"Patient‐Reported and Clinician‐Reported Esthetic Outcomes at Implant Sites Are Not Associated: A Systematic Review With Individual Participant Data Meta‐Analysis","authors":"Sofya Sadilina, Nicolas P. A. Müller, Franz J. Strauss, Ronald E. Jung, Daniel S. Thoma, Stefan P. Bienz","doi":"10.1111/clr.70019","DOIUrl":"https://doi.org/10.1111/clr.70019","url":null,"abstract":"ObjectivesThis systematic review aimed to determine whether patient‐reported outcomes (PROs) are associated with clinician‐reported outcomes (ClinROs) in terms of esthetics in patients with single implant‐supported crowns in the esthetic region.MethodsA systematic electronic search was conducted following a pre‐established protocol to identify randomized controlled trials (RCT) involving patients with single implant‐supported crowns in the esthetic region. Studies had to assess both patient‐ and clinician‐reported outcomes. A two‐stage individual participant data (IPD) meta‐analysis was conducted. First, each study was analyzed separately to obtain correlation coefficients. Second, these estimates were pooled using a random‐effects restricted maximum likelihood (REML) model.ResultsA total of 29 RCTs evaluating 1414 implant‐supported crowns were included, with IPD available for 14 trials evaluating 675 patients. At crown insertion, IPD meta‐analysis from 171 patients across four RCTs showed no significant correlations (<jats:italic>r</jats:italic> = 0.11, 95% CI [−0.04; 0.27], <jats:italic>p</jats:italic> = 0.16) between pink esthetic score (PES) and patient satisfaction with esthetics assessed with visual analogue scale (VAS). At the 1‐year follow‐up, IPD from 502 patients in 11 studies showed a negligible positive correlation (<jats:italic>r</jats:italic> = 0.09, 95% CI [−0.00; 0.18], <jats:italic>p</jats:italic> = 0.06) between PES or modified PES and VAS esthetic satisfaction. At 10‐year follow‐up, data from 80 patients in two studies showed no correlation between modified PES and VAS patient satisfaction (<jats:italic>r</jats:italic> = −0.05, 95% CI [−0.37; 0.27], <jats:italic>p</jats:italic> = 0.75). Regarding white esthetic score (WES) and VAS satisfaction, data from 376 patients in seven studies showed no significant correlations at the 1‐year follow‐up (<jats:italic>r</jats:italic> = 0.03, 95% CI [−0.08; 0.13], <jats:italic>p</jats:italic> = 0.60).ConclusionClinician‐reported outcomes, using PES and WES, showed no correlation with patient‐reported esthetic satisfaction, regardless of the follow‐up duration.Trial RegistrationPROSPERO number CRD42023394920","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"8 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144899108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flapless Mini Implants Immediately Loaded for Full-Arch Overdenture Rehabilitation: An Up-To-15-Year Retrospective Study.","authors":"Gerardo Pellegrino,Zoran Zaccheroni,Subhi Tayeb,Andrea Oliverio,Edoardo Mancuso,Lorenzo Bonifazi,Amerigo Giudice,Carlo Barausse,Pietro Felice","doi":"10.1111/clr.70017","DOIUrl":"https://doi.org/10.1111/clr.70017","url":null,"abstract":"OBJECTIVESThis study aimed to evaluate the survival rates of Mini Dental Implants (MDIs) placed in both the maxilla and the mandible, and their associated overdenture prostheses in edentulous patients over short-, medium-, and long-term follow-up periods.MATERIALS AND METHODSPatients rehabilitated with Mini Dental Implants (diameter ≤ 2.9 mm) as support for overdenture prostheses with a minimum follow-up period of 3 years were included in the study. Data from eligible patients were collected, and marginal bone loss (MBL) was assessed for each implant. The primary outcomes for the prostheses and implants included failure rates, complications, and implant-related MBL.RESULTSThe study analyzed 83 patients and 334 implants over an 8.09 ± 3.96-year mean follow-up. The cumulative implant survival rate at 15 years was 86.3% (95% CI: 79.5%-91.0%). Mean MBL increased from 0.09 ± 0.44 mm at implant placement to 1.79 ± 0.82 mm at 15 years, with Lodi Biomax implants exhibiting significantly lower annual bone loss compared to Dentatus Atlas implants (p < 0.001). The prosthetic survival rate was 95.45% (95% CI: 91.1-99.81). Longer follow-up (p = 0.018) and fewer adjustments (p < 0.001) reduced risks of complication occurrence. Additionally, Lodi Biomax implants had fewer complications compared to Dentatus Atlas (p = 0.039).CONCLUSIONMini Dental Implants with a diameter between 2.4 and 3 mm showed high survival rates over follow-ups of up to 15 years. Their use offers a viable prosthetic solution for edentulous patients, minimizing surgical invasiveness, rehabilitation time, and costs, particularly when a fixed prosthesis is either not feasible or not requested by the patient.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"1 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144792119","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Antibacterial Effect of Combined Electrolytic and Chemical Decontamination Methods on Dental Implant Surfaces: In Vitro Study.","authors":"Verónica Odeh,Leire Virto,Enrique Garcia-Quismondo,David Herrera,Jesús Palma,Mariano Sanz","doi":"10.1111/clr.70012","DOIUrl":"https://doi.org/10.1111/clr.70012","url":null,"abstract":"OBJECTIVESTo evaluate the combined effect of direct electrical current and chlorhexidine digluconate (CHX) for decontaminating titanium implant surfaces, using a validated in vitro oral multispecies biofilm model.MATERIAL AND METHODSContaminated implant surfaces were tested using an electrochemical cell consisting of a three-electrode system immersed in a KI-AL electrolyte, the biofilm-coated implant being the working electrode, a platinum mesh the counter electrode, and an Ag/AgCl electrode the reference. Direct electrical currents (DC) were applied at two voltage levels (-3 V and-0.75 V) for 5 min, followed by a 1-min rinse in 0.12% CHX. The results were compared to 0.12% CHX alone. Untreated contaminated implants served as negative controls. The antibiofilm effect was evaluated by quantitative polymerase chain reaction with propidium monoazide and by scanning electron microscopy in three different implant zones (threads, valleys and transmucosal machined neck). The area of residual bacteria was also calculated by image analysis.RESULTSThe combined treatment significantly reduced the viable total bacterial counts ([-3 V + CHX] = 4.6 and [-0.75 V + CHX] = 4.9 logarithm colony forming units-LogCFU/mL), compared to the negative control group (6.1 LogCFU/mL) and 0.12% CHX alone (6.3 LogCFU/mL). The area of residual bacteria was also significantly reduced, removing over 95% of the biofilm in combined treatment groups, with slightly higher efficiency at -3 V. Electrolytic cleaning was able to reach all implant zones and no significant differences were found between [-3 V + CHX] and [-0.75 V + CHX] for any parameter.CONCLUSIONThe proposed combined treatments were more effective in reducing the vitality of multispecies biofilms on implant surfaces compared to CHX alone.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"31 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144792074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Marginal Bone Changes at Bone-Level Implants With Narrow or Standard Diameter Abutments: 1-Year Results of a Randomised Controlled Trial","authors":"Antonio Liñares,&nbsp;Lucía Maceiras,&nbsp;Lourdes Nóvoa,&nbsp;Alejandro González,&nbsp;Borja Rodríguez,&nbsp;Pilar Batalla,&nbsp;Yago Leira,&nbsp;Juan Blanco","doi":"10.1111/clr.70005","DOIUrl":"10.1111/clr.70005","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To evaluate changes in the peri-implant marginal bone level at implants restored with narrow or standard-diameter abutments after 12 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material &amp; Methods</h3>\u0000 \u0000 <p>Twenty-eight partially edentulous patients were randomly allocated to two groups. The test group consisted of 14 patients restored with a 2.9 mm diameter abutment (21 implants), while the control group included 14 patients restored with a 4.1 mm diameter abutment (17 implants). The primary outcome variable was the radiographic change in the peri-implant marginal bone level at 12 months, measured as the distance from the implant shoulder to the first bone-to-implant contact (fBIC). Secondary outcome variables included clinical peri-implant parameters, the papilla index, biological and mechanical complications, patient-reported outcomes (PROs) and professional aesthetic assessment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A per-protocol analysis was conducted on the 22 patients who completed all scheduled follow-up visits. At the patient level, the change in mean radiographic bone level from definitive prosthesis placement to 12 months showed a reduction in the distance from the implant shoulder to the fBIC of 0.16 ± 0.31 mm in the test group and 0.21 ± 0.34 mm in the control group, with no statistically significant differences between the groups. No statistically significant differences were observed between the two groups for any of the secondary outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Considering the limitations of this study, no significant differences in peri-implant marginal bone levels were found between bone-level implants restored with narrow and standard diameter abutments after 12-month follow-up. Additionally, no differences were observed in clinical variables, patient-reported outcomes, or complications.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 10","pages":"1335-1345"},"PeriodicalIF":5.3,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70005","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144747240","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Five Year Clinical, Radiographic and Soft Tissue Profilometric Outcomes at Two Narrow‐Diameter Implants to Replace Missing Maxillary Lateral Incisors","authors":"Andrea Roccuzzo, Jean‐Claude Imber, Jakob Lempert, Leonardo Mancini, Simon Storgård Jensen","doi":"10.1111/clr.70010","DOIUrl":"https://doi.org/10.1111/clr.70010","url":null,"abstract":"ObjectivesTo compare the 5‐year outcomes in patients with congenitally missing maxillary lateral incisors (MLIs) rehabilitated with two different narrow‐diameter implants (NDIs).Materials and MethodsOne‐hundred patients rehabilitated with a cement‐retained bi‐layered zirconia single‐unit crown on either a Ø2.9 mm (Test) (<jats:italic>n</jats:italic> = 50) or a Ø3.3 mm (Control) (<jats:italic>n</jats:italic> = 50) (T1) were assessed at 1‐, 3‐, and 5‐year follow‐up (T2, T3, T4). Clinical, radiographic, patient‐reported outcome measures (PROMs), biological/technical complications, and esthetic ones were recorded. After the acquisition of intraoral optical scans (IOS) (T4), three different soft tissue profilometric profiles (linear, concave, and convex) were identified.ResultsAt T4, 66 patients (<jats:italic>n</jats:italic> = 33 per group; drop‐outs <jats:italic>n</jats:italic> = 33; implant survival rate: 99%; early implant loss <jats:italic>n</jats:italic> = 1) were evaluated. Between T1 and T4, crestal bone level (CBL) changes at Ø3.3 and at Ø2.9 mm implants were comparable (difference: 0.24 mm; <jats:italic>p</jats:italic> &gt; 0.05). Despite the positive recorded esthetic scores (i.e., Score 1–2), at T4, 9.1% of Ø2.9 mm versus 18.2% of Ø3.3 mm implants displayed alveolar process deficiency (Score 3). The frequency of soft tissue profilometric profiles was linear (21.2% vs. 40.6%), concave (72.7% vs. 37.5%) and convex (6.1% vs. 21.9%) (Ø2.9 mm vs. Ø3.3 mm group [<jats:italic>p</jats:italic> &gt; 0.01]). Complications included decementation, ceramic chipping of the incisal edge (3× each), abutment loosening (1×) and a buccal fistula (3×). The statistically significant improved PROMs values at T1 remained stable up to T4 for both groups (<jats:italic>p</jats:italic> &gt; 0.05).ConclusionThe use of Ø2.9 or Ø3.3 mm implants showed comparable positive long‐term results. Clinicians can rely on both implant types to replace congenitally missing MLIs.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"15 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715664","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Clinician's Experience on the Accuracy of Dental Implant Placement by Dynamic Computer‐Assisted Surgery Systems: A Systematic Review and Meta‐Analysis","authors":"Lata Goyal, Komal Kaur Saroya, Hariram Sankar, Meghna Dewan, Kirti Chawla, Gunjan Pruthi","doi":"10.1111/clr.70009","DOIUrl":"https://doi.org/10.1111/clr.70009","url":null,"abstract":"AimTo synthesize evidence on the effect of clinicians' experience on the accuracy of implants placed using Dynamic Computer‐Assisted Surgery systems (dCAIS).MethodsPubMed, Scopus, EMBASE, and Cochrane Library were searched till April 19, 2025, for research reporting implant accuracy with dCAIS along with the influence of the operator's experience. Clinicians who had placed implants with dCAIS (dCAIS‐Ex) were compared with those without any prior experience with dCAIS (dCAIS‐IEx), irrespective of their experience with implant surgery; clinicians placing implants with dCAIS with or without prior experience in implant surgeries were also compared (IEx vs. I‐InEx). The risk of bias was assessed with ROBINS‐I for in vivo and QUIN tool for in vitro studies. Meta‐analyses were performed to evaluate implant accuracy (coronal, apical, and angular deviations) and operating time.Results4 in vivo and 10 in vitro studies were included. Pooled analysis of in vivo and in vitro studies showed significant differences in angular deviation [SMD = −0.35 (−0.69, −0.01), <jats:italic>p</jats:italic> = 0.04; SMD = −0.39 (−0.62, −0.17), <jats:italic>p</jats:italic> = 0.0007], where dCAIS‐Ex clinicians showed lower deviations than dCAIS‐IEx clinicians. No statistical difference was observed in implant accuracy between I‐Ex versus I‐IEx clinicians. Data was highly heterogeneous to report conclusive evidence on operating time with dCAIS between respective groups.ConclusionsThe influence of clinicians' experience was significant only on angular deviation when implants were placed by dCAIS‐Ex vs. dCAIS‐InEx clinicians. However, the small magnitude of difference might not be clinically perceptible. More randomized clinical trials with high quality and standardized methodology are required to synthesize meaningful evidence.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"708 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144715665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Anatomically Based Multitask Deep Learning Radiomics Nomogram Predicts the Implant Failure Risk in Sinus Floor Elevation.","authors":"Yujie Zhu,Yang Liu,Yue Zhao,Qinyi Lu,Wendi Wang,Yuan Chen,Ping Ji,Tao Chen","doi":"10.1111/clr.70011","DOIUrl":"https://doi.org/10.1111/clr.70011","url":null,"abstract":"OBJECTIVESTo develop and assess the performance of an anatomically based multitask deep learning radiomics nomogram (AMDRN) system to predict implant failure risk before maxillary sinus floor elevation (MSFE) while incorporating automated segmentation of key anatomical structures.MATERIALS AND METHODSWe retrospectively collected patients' preoperative cone beam computed tomography (CBCT) images and electronic medical records (EMRs). First, the nn-UNet v2 model was optimized to segment the maxillary sinus (MS), Schneiderian membrane (SM), and residual alveolar bone (RAB). Based on the segmentation mask, a deep learning model (3D-Attention-ResNet) and a radiomics model were developed to extract 3D features from CBCT scans, generating the DL Score, and Rad Score. Significant clinical features were also extracted from EMRs to build a clinical model. These components were then integrated using logistic regression (LR) to create the AMDRN model, which includes a visualization module to support clinical decision-making.RESULTSSegmentation results for MS, RAB, and SM achieved high DICE coefficients on the test set, with values of 99.50% ± 0.84%, 92.53% ± 3.78%, and 91.58% ± 7.16%, respectively. On an independent test set, the Clinical model, Radiomics model, 3D-DL model, and AMDRN model achieved prediction accuracies of 60%, 76%, 82%, and 90%, respectively, with AMDRN achieving the highest AUC of 93%.CONCLUSIONThe AMDRN system enables efficient preoperative prediction of implant failure risk in MSFE and accurate segmentation of critical anatomical structures, supporting personalized treatment planning and clinical risk management.","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"52 1","pages":""},"PeriodicalIF":4.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144693309","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osseointegration in the Absence of Primary Stability: An Experimental Preclinical Mandibular Minipig Overpreparation In Vivo Model","authors":"Thomas Gill,&nbsp;Hansley Ooi,&nbsp;Emre Tezulas,&nbsp;Aviva Petrie,&nbsp;Simon Rawlinson,&nbsp;Mario Roccuzzo,&nbsp;Shakeel Shahdad","doi":"10.1111/clr.70006","DOIUrl":"10.1111/clr.70006","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The effect of osteotomy overpreparation, and thus lack of primary stability, on implant osseointegration and crestal bone volume maintenance was investigated by comparing placement of dental implants with either a standard osteotomy preparation (NP) or an overprepared osteotomy (OP) where the final osteotomy drill was larger in diameter than the implant placed.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Bone-level implants (Ø3.3 mm diameter) were placed in the mandible of minipigs with two preparation techniques: an NP (Group 1) and an OP to a final osteotomy of 3.5 mm in diameter (Group 2) and submerged for 2 and 8 weeks. An Implant Stability Quotient (ISQ) was measured for each implant at placement. Implant survival, defined histologically as the absence of fibrous encapsulation and the presence of direct bone-to-implant contact, osseointegration and crestal bone formation were analysed histologically and histomorphometrically to compare the preparation techniques.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A 100% survival for both preparation types was observed. The mean ISQ at insertion for Groups 1 and 2 was 69.35 a.u. (95% CI: 68.02–70.68) and 11.95 a.u. (95% CI: 10.53–13.37) respectively (<i>p</i> &lt; 0.001). At 2 and 8 weeks, there was no difference between the two groups for total bone-to-implant contact (tBIC) (<i>p</i> &gt; 0.05). Group 2 demonstrated significantly higher mean first bone-to-implant contact (fBIC), coronal bone-to-implant contact (cBIC) and bone-area-to-total-area (BATA) at 2 and 8 weeks compared to Group 1 (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Implants inserted into an overprepared osteotomy with no primary stability successfully osseointegrated. At 2 and 8 weeks, OP resulted in significantly more coronal bone apposition and maintenance of coronal bone volume as measured by fBIC, cBIC and BATA.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 10","pages":"1346-1359"},"PeriodicalIF":5.3,"publicationDate":"2025-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70006","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144684290","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical and Radiographic Changes at Implants Supporting Fixed Partial Dental Prostheses With Cantilever Extensions. A Retrospective Study After at Least 10 Years of Loading","authors":"Alexios Bakopoulos,&nbsp;Haralampos Petridis,&nbsp;Konstantinos Michalakis,&nbsp;Lazaros Tsalikis,&nbsp;Ioannis Vouros","doi":"10.1111/clr.70000","DOIUrl":"10.1111/clr.70000","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Aim</h3>\u0000 \u0000 <p>To report clinical and radiographic changes at implants supporting Fixed Partial Dental Prostheses with Cantilever extensions (FPDPC's) after a loading time exceeding 10 years.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Patients with FPDPC's were reevaluated after a loading time of 10–21 years. A clinical and radiographic examination was conducted to assess Marginal bone level change (MBLc), biological, and prosthetic parameters. Pocket depth (PD), Attachment Level (CAL), Bleeding on Probing (BOP), and Presence of Plaque (PL) were also recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Nineteen patients with 21 FPDPC's supported by 47 implants were re-evaluated after a mean loading time of 13.3 ± 2.9 years (range: 10–21 years). Implant survival rate was 100% and implant success rate was 91.5%, accounting for 4 implants (8.5%) that presented with peri-implantitis. Twelve implants (25.5%) exhibited peri-implant mucositis. Three of the FPDPC's had to be replaced due to fracture of the cantilever teeth and one other FPDPC had abutment screw fracture which was corrected, leading to prosthetic survival and success rates of 86% and 81%, respectively. Mean MBLc from implant placement to time of re-evaluation was 0.99 ± 1.11 mm (95% CI: 0.67, 1.31, <i>p</i>-value &lt; 0.001). Mean PD at re-evaluation was 3.9 ± 1.6 mm, mean CAL was 1.2 ± 1.6 mm. Percentages of BOP and PL were 14.89% ± 23.11% and 26.6% ± 30.625 respectively.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Fixed partial dental prostheses with cantilever extensions are a reliable option if extensive bone grafting or sinus lifts are to be avoided, with 10-year results showing 100% implant survival, 90% implant success, and 86% and 81% prosthetic survival and success rates, respectively.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 10","pages":"1271-1286"},"PeriodicalIF":5.3,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70000","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144677553","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Neutrophil Extracellular Traps Induce Pyroptosis of Gingival Fibroblasts in Peri-Implantitis","authors":"Jiangbo Li,&nbsp;Zhixin Li,&nbsp;Kailibinuer Abuduwaili,&nbsp;Jiaying Song,&nbsp;Yue Sun,&nbsp;Zhuofan Chen,&nbsp;Danying Chen,&nbsp;Baoxin Huang","doi":"10.1111/clr.70002","DOIUrl":"10.1111/clr.70002","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study aimed to verify the release of neutrophil extracellular traps (NETs) in peri-implantitis and explore whether NETs induce pyroptosis and inflammatory responses in human gingival fibroblasts (HGFs).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Peri-implant soft tissue samples were collected from healthy individuals and patients with peri-implantitis. NETs and the expression of pyroptosis-related factors including NLRP3, Caspase1, GSDMD, and IL-1β were detected. In vitro, NETs induced from differentiated HL60 (dHL60) cells and human neutrophils were used to stimulate HGFs. Transcriptome sequencing analysis and functional enrichment analysis were performed to analyze the influence of NETs on programmed cell death and inflammatory-related signaling pathways in HGFs. Further investigations were conducted to explore the changes in cell viability, cell membrane permeability, and the expression levels of inflammatory factors and pyroptosis-related markers in HGFs treated with NETs in the presence or absence of DNase I.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Compared to healthy samples, the release of NETs was significantly elevated in soft tissues with peri-implantitis, accompanied by increased expression of NLRP3, Caspase1, GSDMD, and IL-1β. Functional enrichment analyses revealed that NETs activated signaling pathways related to pyroptosis and inflammatory responses of HGFs. Meanwhile, the results of the in vitro study revealed that NETs reduced cell viability, increased cell membrane permeability, and upregulated expression of inflammatory cytokines and pyroptosis markers in HGFs, which were partially reversed by DNase I treatment.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>NETs may exacerbate the pathological progression of peri-implantitis by inducing pyroptosis and inflammatory responses in HGFs. Targeting NETs may offer a potential therapeutic strategy to mitigate the inflammation in peri-implantitis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 10","pages":"1296-1311"},"PeriodicalIF":5.3,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144669400","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}