Clinical Oral Implants Research最新文献

{"title":"Implant Therapy in Patients With Neurodegenerative Diseases—A Scoping Review","authors":"Lysandre David,&nbsp;Sabrina Maniewicz,&nbsp;Najla Chebib,&nbsp;Gabriel Gold,&nbsp;Murali Srinivasan,&nbsp;Frauke Müller","doi":"10.1111/clr.70080","DOIUrl":"10.1111/clr.70080","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The increasing longevity of populations has resulted in a growing number of older adults requiring prosthodontic care, including those with neurodegenerative diseases (NDs). Neurodegenerative diseases pose significant challenges to prosthodontic care, and it remains unclear whether implant therapy in this population achieves outcomes comparable to those observed in the general older population.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>A first systematic review was reframed to a scoping review using a PCC framework with Population (individuals with neurodegenerative diseases, who were partially or completely edentulous), Concept (implant therapy, planning, placement and maintenance, and any reported complications) and Context (dental and geriatric care settings).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The literature search identified 634 studies or case reports, of which none fulfilled the inclusion criteria. Seven papers (1 retrospective study, 2 prospective studies and 4 case reports) outside the inclusion criteria reported on patients with neurodegenerative diseases receiving implants, which suggest that dental implants seem to offer initial benefits in improving chewing efficiency, the quality of life and weight gain, especially in Parkinson's disease (PD) patients. However, their suitability for patients with advanced ND is uncertain.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Although high-level evidence on implant survival and success in patients with neurodegenerative diseases is lacking, the limited available evidence offers promising indications of reasonably successful implant treatments in early-stage cases. However, continuous monitoring of disease progression, oral health and denture management is crucial to retrofit the restoration when necessary.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 3","pages":"237-246"},"PeriodicalIF":5.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70080","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145994946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Performance of Ultra-Porous TiO2 Scaffold as Bone Graft Substitute in Human Alveolar Ridge Preservation—A Feasibility Study","authors":"Ingvild Nysæther,&nbsp;Håvard Jostein Haugen,&nbsp;Thaqif El Khassawna,&nbsp;Reem Jamous,&nbsp;Shoresh Afnan,&nbsp;Marco Santacroce,&nbsp;Linda Z. Arvidsson,&nbsp;Torben Hildebrand,&nbsp;S. Petter Lyngstadaas,&nbsp;Jan Eirik Ellingsen","doi":"10.1111/clr.70074","DOIUrl":"10.1111/clr.70074","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This study evaluates the safety and osteoconductive potential of a ceramic TiO₂ scaffold in human alveolar bone, hypothesising that placement in human extraction sockets is safe, supports bone ingrowth and preserves ridge dimensions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Nine subjects requiring the extraction of ≥ 1 premolar or molar tooth were enrolled. Full-thickness mucoperiosteal flaps were elevated. Following tooth extraction, porous ceramic TiO₂ scaffolds were adjusted chair-side, placed into the extraction socket and covered by a resorbable collagen membrane. After 6 months of healing, before dental implant placement, a biopsy was performed at the site where the scaffold had been placed. Histomorphometric and micro-CT analyses were made. CBCT images were made at baseline and at 6 months to assess alveolar ridge dimensional changes. Implants placed in regenerated bone were followed for 21 months.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Scaffold customisation with chairside adjustment was straightforward. No serious adverse events were observed during the 6 months following scaffold implantation. One scaffold was removed due to an early exposure, while the remaining 9 scaffolds successfully integrated. Two sites presented with minor soft tissue dehiscences at 1–2 weeks, which healed spontaneously. Micro-CT and histology confirmed new bone formation. Soft tissue healing was favourable, with no adverse reactions. Dimensional analysis revealed minimal changes in alveolar ridge width and height, indicating effective preservation of volume.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This clinical study confirms that TiO₂ scaffolds are a safe and effective option for promoting bone regrowth and preserving volume in human alveolar bone, thereby facilitating bone formation and maintaining ridge dimensions post-extraction.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>This trial was registered at ClinicalTrials.gov (NCT06269497) on 1 December 2022</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 3","pages":"327-344"},"PeriodicalIF":5.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145645019","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pannexin1 Inhibition Suppresses Porphyromonas gingivalis-Induced Ferroptosis in Peri-Implantitis by Regulating the NRF2/SLC7A11/GPX4 Pathway","authors":"Yujia Wang,&nbsp;Yiyi Zhu,&nbsp;Xingan Wang,&nbsp;Wenqi Su,&nbsp;Jiahong Shi,&nbsp;Cancan Zu,&nbsp;Lang Lei,&nbsp;Houxuan Li","doi":"10.1111/clr.70082","DOIUrl":"10.1111/clr.70082","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>Pannexin1 (Panx1), a channel-forming protein, has been implicated in multiple forms of programmed cell death. This study aimed to investigate the role and underlying molecular mechanisms of Panx1 in regulating ferroptosis during peri-implantitis (PI).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Panx1 expression in PI patients was evaluated through bioinformatics analysis and validated using clinical samples. In vitro, <i>Porphyromonas gingivalis</i>-stimulated osteoblasts were assessed for changes in Panx1 and ferroptosis-related markers. After Panx1 inhibition or knockdown, cellular iron content, reactive oxygen species levels, and lipid peroxidation were measured to evaluate ferroptosis. In vivo, a mouse model of <i>P. gingivalis</i>-induced PI was established to evaluate the effects of pharmacological Panx1 inhibition on ferroptosis and peri-implant bone loss.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Bioinformatic analysis revealed that Panx1 was significantly upregulated in PI tissue. Clinical samples confirmed that Panx1 expression at both gene and protein levels was markedly elevated in PI tissues compared to healthy controls. In vitro, <i>P. gingivalis</i> upregulated Panx1 expression and induced ferroptosis, characterized by increased lipid peroxidation, iron overload, and ROS accumulation. Panx1 inhibition or knockdown alleviated these ferroptosis-related changes and was associated with the upregulation of the NRF2/SLC7A11/GPX4 antioxidant signaling pathway. In vivo, Panx1-inhibited PI mice significantly restored the expression of key anti-ferroptosis proteins in peri-implant tissues and markedly reduced vertical and circumferential alveolar bone loss around implants compared to untreated PI mice.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Panx1 inhibition suppressed <i>P. gingivalis</i>-induced ferroptosis in PI accompanied by the upregulation of the NRF2/SLC7A11/GPX4 antioxidant pathway. Targeting Panx1 may provide a potential therapeutic strategy for treating PI.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 3","pages":"357-372"},"PeriodicalIF":5.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Neck Design on Peri-Implant Hard and Soft Tissues: A 12-Month Randomized Clinical Trial of Immediately Placed Implants","authors":"Cristina Porta-Ferrer,&nbsp;Basel Elnayef-Elsakan,&nbsp;Fernando Suárez-López del Amo,&nbsp;Jordi Caballé-Serrano,&nbsp;Marta Satorres-Nieto,&nbsp;Federico Hernández-Alfaro","doi":"10.1111/clr.70068","DOIUrl":"10.1111/clr.70068","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The objective of this RCT was to compare clinical and radiographic outcomes after immediate implant placement and temporization of two neck geometries: a traditional round neck (RN) and an innovative triangular neck (TN).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Thirty-six patients were enrolled and randomly assigned to TN (test) or RN (control) groups for an immediate implant placement and provisionalization protocol in the anterior maxilla. Buccal bone width (BBW) was assessed by cone-beam computed tomography (CBCT) immediately after implant placement and 4 months later, when the definitive crown was placed. The following parameters were measured on the day of surgery: insertion torque (IT), implant stability quotient (ISQ), crestal width (CW), and soft tissue thickness (STT) at 3 and 5 mm from the gingival margin. Postoperatively, at 4 and 12 months, the MBL, pocket depth (PD), bleeding on probing (BOP), CW, and STT at 3 and 5 mm were recorded.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Two implants per group failed to integrate; in both groups, 1 year implant survival and success rates were 88.9%. At 4 months, BBW was not significantly different between groups (<i>p</i> &gt; 0.05). At 12 months, no significant differences were found in MBL, PD, BOP, CW, or STT (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This randomized trial did not demonstrate superiority of the triangular neck over the round neck at 12 months. Estimates and confidence intervals are compatible with small between-group differences. As the study was not designed or powered for equivalence, no equivalence claims are made.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>ClinicalTrials.gov identifier: NCT05944419</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 3","pages":"287-302"},"PeriodicalIF":5.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145583118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impact of a Bioadhesive Oral Wound Dressing Combined With Flowable Resin on Patient-Reported Outcomes After Palatal Graft Harvesting: A Randomized Clinical Trial","authors":"Sergio García-Moreno,&nbsp;Rosa María López-Pintor,&nbsp;Isabel Leco-Berrocal,&nbsp;Jesús Torres,&nbsp;José González-Serrano","doi":"10.1111/clr.70070","DOIUrl":"10.1111/clr.70070","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the effect of a cellulose-based oral wound dressing (OWD) stabilized with flowable resin (FR), in combination with hemostatic sponges, on patient-reported outcomes (PROMs) after palatal graft harvesting.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This randomized clinical trial included patients requiring soft tissue augmentation with dental implants. Participants were allocated to three groups: OWD and FR (OWDFR), cyanoacrylate (CY), or palatal plate (PP). The primary outcome was postoperative pain, assessed with a 10-cm visual analog scale (VAS) over 14 days. Secondary outcomes were analgesic consumption, oral health-related quality of life (OHIP-14), postoperative bleeding, and willingness to repeat the procedure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Sixty-one patients were enrolled. The OWDFR group reported lower VAS values on Days 1, 2, 3, and 7 compared with CY and PP (<i>p</i> &lt; 0.05). On Day 2, VAS scores were significantly lower in OWDFR, with mean differences of −1.94 versus CY and −2.12 versus PP (<i>p</i> &lt; 0.01). Analgesic intake differed significantly on Days 3 and 5; on Day 3, OWDFR consumed −0.89 tablets compared to PP and CY consumed −0.95 tablets compared to PP (both <i>p</i> &lt; 0.05). OHIP-14 scores were similar across groups, but OWDFR patients reported greater early postoperative comfort. No bleeding or adverse events occurred. All OWDFR patients were willing to repeat the procedure, compared with 90% in CY and 85% in PP.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>The combination of a bioadhesive OWD with FR appears to be a safe and minimally invasive method for protecting palatal donor sites. It reduces postoperative pain and analgesic use while enhancing comfort, supporting its incorporation into routine clinical protocols.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Protocol registered at clinicaltrials.gov (NCT06408792)</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 3","pages":"303-313"},"PeriodicalIF":5.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145484861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Buccal Bone Dimensional Changes Following Implant Placement and Guided Bone Regeneration With Submerged or Transmucosal Approach: A Cone Beam Computed Tomography Study","authors":"Haider Alramli,&nbsp;Robert Kelley,&nbsp;Stavros Sofos,&nbsp;Theofilos Koutouzis","doi":"10.1111/clr.70083","DOIUrl":"10.1111/clr.70083","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The aim was to compare buccal bone dimensional changes following implant placement with simultaneous guided bone regeneration (GBR), using either a submerged or transmucosal healing approach.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>In this randomized, controlled clinical study, twenty-eight patients with a single implant placed at a restorative-driven position and with at least 2 mm of the coronal aspect of the implant exposed were allocated to be treated with GBR, either with a submerged healing approach (SBM Group) or a transmucosal healing approach (TSM Group). Cone beam computed tomography (CBCT) studies were taken immediately following treatment (T0) and at 4 months (T1). Vertical bone gain (VGAIN) was the primary outcome variable. Defect resolution, radiographic vertical defect height (RVDH), and radiographic bone thickness (RBT) were evaluated and compared.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>No significant differences were found between the groups for defect height resolution, VGAIN, RVDH, and RBT (<i>p</i> &gt; 0.05). A significant reduction in RBT was found between T0 and T1 within the groups (<i>p</i> &lt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The study found no significant differences in buccal bone dimensional changes between submerged and transmucosal healing approaches when implants were placed with simultaneous GBR.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 3","pages":"373-382"},"PeriodicalIF":5.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145836135","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tobacco Smoking and Smoke-Free Products as Risk Factors for Dental Implants: A Systematic Review","authors":"Calciolari Elena,&nbsp;Corbella Stefano,&nbsp;Dourou Marina,&nbsp;Ercal Pinar,&nbsp;Donos Nikolaos","doi":"10.1111/clr.70108","DOIUrl":"10.1111/clr.70108","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This systematic review aimed to investigate the effect of tobacco smoking and smoke-free products as risk factors for dental implants.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Three databases were searched to identify studies reporting on the risk of implant failure/survival in tobacco smokers or smoke-free users as compared to non-smokers in studies with ≥ 1 year of follow-up post-implant loading. Data on biological complications and radiographic peri-implant crestal bone loss (CBL) were also collected. Meta-analyses computed the Odds Ratio (OR) of implant survival with its confidence interval by applying the DerSimonian and Laird's random effect method, with <i>p</i> set at &lt; 0.01.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Forty-five articles reporting on 44 studies were included, 41 of which reported on the effect of cigarette smoking, with a follow-up from 1 to up to 17 years. Overall, a significantly reduced implant survival both at implant and patient level was indicated in cigarette smokers (OR = 0.40, 95% CI 0.27; 0.61, <i>p</i> &lt; 0.001 and OR = 0.43, 95% CI 0.20; 0.90, <i>p</i> = 0.02, respectively). An increased CBL of 0.64 mm (95% CI 0.29; 0.99, <i>p</i> &lt; 0.001) was also suggested in cigarette smokers, and the majority of studies reported a higher incidence of peri-implantitis. Insufficient data are available for smoke-free users.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although tobacco smoking is not considered an absolute contraindication for implant therapy, evidence indicates that it has a detrimental effect on peri-implant tissues, leading to an increased risk of implant failure and crestal bone loss. Individual behavioural counselling for smoking cessation should always be integrated in the treatment plan of patients receiving implant-supported rehabilitations.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>PROSPERO number: CRD42024628116</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 3","pages":"262-286"},"PeriodicalIF":5.3,"publicationDate":"2026-03-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.70108","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147346399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"","authors":"","doi":"","DOIUrl":"","url":null,"abstract":"","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 5","pages":"643-656"},"PeriodicalIF":5.3,"publicationDate":"2026-02-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148092363","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"1st Global Consensus for Clinical Guidelines for the Rehabilitation of the Edentulous Maxilla: Single-Round Survey on Implant-Supported Fixed and Removable Prostheses","authors":"Guo-Hao Lin,&nbsp;Franz J. Strauss,&nbsp;Giulia Brunello,&nbsp;Charlotte Stilwell,&nbsp;Ronald E. Jung,&nbsp;Ina Kopp,&nbsp;Frank Schwarz,&nbsp;Hom-Lay Wang","doi":"10.1111/clr.70027","DOIUrl":"10.1111/clr.70027","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This single-round survey on prosthodontic rehabilitation of the edentulous maxilla is one of four clinician surveys commissioned prior to the first Global Consensus for Clinical Guidelines (GCCG). Within the GCCG aim of refining treatment protocols and enhancing patient care, this survey gathered expert insights into best practices, challenges, and treatment outcomes for these complex restorative procedures.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>The 25-item survey was sent to 230 identified experts from 41 countries in October 2024. Participation in the survey was voluntary and without incentives. Informed consent was obtained at the beginning of the survey. All data were collected, stored, and processed anonymously.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Of the 230 experts contacted, 123 accessed the survey and 121 provided consent and completed the questionnaire, resulting in a response rate of 52.6%. The survey responses identified 13 statements that reached consensus (&gt; 75% but ≤ 95% agreement) and five that reached strong consensus (&gt; 95% agreement). These 18 statements were derived from 6 items addressing the topics of anatomical landmarks for tooth positioning, preferred distal implant position, preferred minimum implant diameter, preferred retention method, relevant patient-reported outcomes, and relevant clinician-reported outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>This study gathered valuable expert insights to inform a consensus development process for establishing clinical practice guidelines for management of the edentulous maxilla. The survey identified 18 statements from six items that reached consensus or strong consensus among survey respondents. The items not achieving consensus served to reflect real-world implant treatment strategies, identify literature gaps, and highlight any inconsistencies between expert consensus and current evidence.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 S30","pages":"S121-S134"},"PeriodicalIF":5.3,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12930127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus Report of Group 1 of the 1st Global Consensus for Clinical Guidelines for the Rehabilitation of the Edentulous Maxilla: Number of Implants, Timing of Implant Placement and Loading","authors":"Nikos Donos,&nbsp;Ethan Ng,&nbsp;Claudio Mendes Pannuti,&nbsp;Giuseppe Alexandre Romito,&nbsp;Helena Cristina Oliveira Francisco,&nbsp;Samir Abou-Ayash,&nbsp;Gustavo Avila-Ortiz,&nbsp;Joao Manuel Mendez Carames,&nbsp;Paolo Casentini,&nbsp;Tali Chackartchi,&nbsp;Vivianne Chappuis,&nbsp;Stephen Chen,&nbsp;Paul Fugazzotto,&nbsp;William V. Giannobile,&nbsp;Yoshiyuki Hagiwara,&nbsp;Adam Hamilton,&nbsp;Saso Ivanovski,&nbsp;Sergio Kahn,&nbsp;Joseph Kan,&nbsp;France Lambert,&nbsp;Robert Alan Levine,&nbsp;Jose Manuel Navarro,&nbsp;Turker Ornekol,&nbsp;Michael Payer,&nbsp;Todd Schoenbaum,&nbsp;Manish Kumar Singh,&nbsp;Sejal Thacker,&nbsp;Gil Alcoforado","doi":"10.1111/clr.70063","DOIUrl":"10.1111/clr.70063","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>The 1st Global Consensus for Clinical Guidelines (GCCG) in Implant Dentistry introduced an innovative, evidence-based approach to developing patient-centered and practical recommendations for the rehabilitation of the edentulous maxilla. Within this framework, Group 1 aimed to formulate clinical recommendations on the number of implants required, timing of implant placement, and timing of loading.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Group 1 followed the S2k-level guideline framework of the Association of the Scientific Medical Societies in Germany (AWMF), using a structured nominal group technique. The evidence base included three systematic reviews evaluating clinician-reported outcomes (ClinROs) and patient-reported outcomes (PROs), supplemented by structured single-round international surveys involving expert clinicians, patients, and cross-disciplinary experts. Survey content covered diagnostics, treatment planning, clinical procedures, and maintenance care. Draft recommendations were discussed during the in-person consensus meeting in Boston (June 16–18, 2025) and finalized through anonymous plenary voting. Consensus was defined as ≥ 75% and ≤ 95% agreement and strong consensus as &gt; 95% agreement.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Group 1 formulated 12 clinical recommendations across the workflow domains of diagnostic tools, treatment planning, and treatment procedure. During plenary voting, three of these recommendations reached strong consensus, and nine achieved consensus. The number of voters per recommendation ranged from 61 to 90, with an average of 83.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>This consensus report provides structured, evidence-based recommendations on implant number, placement timing, and loading protocols for rehabilitation of the edentulous maxilla. These guidelines are intended to support individualized, patient-centered care while also identifying priority areas for future research.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"37 S30","pages":"S28-S48"},"PeriodicalIF":5.3,"publicationDate":"2026-02-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12930125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147275599","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}