Clinical Oral Implants Research最新文献

{"title":"Effect of Nonsurgical Mechanical Debridement With or Without Chlorhexidine Formulations in the Treatment of Peri-Implant Mucositis. A Randomized Placebo-Controlled Clinical Trial","authors":"Gaetano Isola, Alessandro Polizzi, Maria Santagati, Angela Alibrandi, Vincenzo Iorio-Siciliano, Luca Ramaglia","doi":"10.1111/clr.14405","DOIUrl":"10.1111/clr.14405","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To evaluate the treatment of peri-implant mucositis (PM) using a nonsurgical submarginal peri-implant instrumentation (NSPI) with or without chlorhexidine (CHX) solutions.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Fifty-six patients (28 per group) were randomly assigned to the test (NSPI + 0.12% mouthwash and subgingival CHX irrigation plus tongue brushing with 1% CHX gel) or the control group (NSPI + placebo mouthwash and subgingival placebo irrigation plus tongue brushing with placebo gel). At baseline, 1, 3, 6 months, bleeding on probing (BOP), probing pocket depth (PPD), modified gingival index (mGI), modified plaque index (mPlI), full-mouth plaque score (FMPS), full-mouth bleeding score (FMBS), and the proportions of \u0000 <i>Aggregatibacter actinomycetemcomitans</i>\u0000 , \u0000 <i>Porphyromonas gingivalis</i>\u0000 , \u0000 <i>Tannerella forsythia</i>, and \u0000 <i>Treponema denticola</i>\u0000 were recorded. The BOP reduction was set as a primary outcome. Data were analyzed to assess BOP reduction at a 6-month follow-up and to identify significant predictors of implant-site BOP through mixed generalized linear regression.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>After 6 months in both groups, a significant reduction of BOP, PD, mPlI, mGI, FMBS, and FMPS was noted (<i>p</i> < 0.05). However, at 6 months, the test group was more effective than the controls in reducing median BOP (∆values control/test: 39.3% [95% CI 37.4–42.3] vs. 48.7 [95% CI 46.5–51.2], <i>p</i> = 0.044), as well as mPlI (<i>p</i> = 0.041) and the proportion of \u0000 <i>Treponema denticola</i>\u0000 (<i>p</i> = 0.039). Moreover, the implant-sites BOP reduction was significantly influenced by test treatment (<i>p</i> < 0.001), history of periodontitis (<i>p</i> = 0.003), and a high number of cigarettes/day (<i>p</i> = 0.002), the proportion of \u0000 <i>Porphyromonas gingivalis</i>\u0000 (<i>p</i> = 0.021) and \u0000 <i>Tannerella forsythia</i>\u0000 (<i>p</i> = 0.032).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>NSPI + CHX showed better results compared to placebo in implant-sites BOP reduction. The high number of cigarettes/day and the proportion of \u0000 <i>Porphyromonas gingivalis</i>\u0000 and \u0000 <i>T. forsythia</i>\u0000 negatively influenced the BOP reduction in PM-treated patients.</p>\u0000 ","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 5","pages":"566-577"},"PeriodicalIF":4.8,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14405","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Long-Term Clinical Outcomes and Risk Indicator Analyses of Narrow-Diameter Implants in the Posterior Jaw: A Retrospective Cohort Study of 10 to 27 Years","authors":"Jingxian Zhu,&nbsp;Wei Sun,&nbsp;Shanyi Yang,&nbsp;Zhili Du,&nbsp;Rui Yang,&nbsp;Bin Shi,&nbsp;Wei Ji","doi":"10.1111/clr.14409","DOIUrl":"10.1111/clr.14409","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>To assess the long-term clinical outcomes and patient satisfaction with narrow-diameter implants (NDIs) in the posterior jaws and to identify the risk indicators for NDI failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>This retrospective study reviewed 479 patients with 666 NDIs (diameter ≤ 3.5 mm) -supported fixed prostheses in posterior jaws, with a minimum 10-year follow-up. Implant survival, success, complications, demographics, and implantation characteristics were collected. Risk indicators for posterior NDI failure were analyzed using multilevel Cox regression analyses with mixed effects. Patient satisfaction and oral health impact profile (OHIP) were surveyed in a random 10% sample.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Over a mean follow-up of 14.0 ± 3.6 years, implant survival was 95.9% at the implant level and 94.6% at the patient level. Success rates were 93.5% at the implant level and 91.6% at the patient level. Multilevel Cox regression analysis identified an implant length of 10 mm or less (<i>p</i> = 0.001) and the use of single crowns (<i>p</i> = 0.005) as significant risk indicators for posterior NDI failure. Patients showed high satisfaction (4.54/5) with posterior NDIs, and the mean OHIP score of 1.15 reflected an acceptable level of oral health.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>NDIs in the posterior jaws demonstrated robust long-term success and high patient satisfaction. An implant length of 10 mm or less and the use of single crowns are potential risk indicators for posterior NDI failure.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Trial Registration</h3>\u0000 \u0000 <p>Chinese Clinical Trial Registry: ChiCTR2200062337 on 2022/08/02</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 5","pages":"613-625"},"PeriodicalIF":4.8,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143034995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Zirconia Barriers in Bone Regeneration Procedures: A Scoping Review","authors":"Xavier Uriarte,&nbsp;Andrés Landázuri,&nbsp;Heloisa Fonseca Marão,&nbsp;Natália Lucena,&nbsp;Eik Schiegnitz,&nbsp;Leonardo Díaz","doi":"10.1111/clr.14404","DOIUrl":"10.1111/clr.14404","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Purpose</h3>\u0000 \u0000 <p>To identify the current status and development of zirconia barriers in bone augmentation procedures in the maxillofacial area of adult human patients.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Two independent reviewers conducted an electronic literature search in PubMed/MEDLINE, Web of Science, Scopus, EBSCO, the Cochrane Library, and LILACS databases, as well as a manual search to identify eligible clinical studies up to April 15, 2024. The protocol was designed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews guidelines.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The initial electronic search resulted in 240 studies. The systematic application of inclusion and exclusion criteria resulted in 6 articles that met the purpose of the study. The included articles were 5 clinical case series and 1 case report, published between 2016 and 2023. Only 4 articles reported histological studies. A total of 40 sites regenerated with zirconium barriers were reported in 30 patients. Results were obtained with variability in bone gain values, between 0.9–8.0 mm horizontally and 1.4–12.0 mm vertically, in addition to a 30% complication rate.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Although the results obtained in the studies included in this scoping review are favorable with respect to the amount of bone formation and the reduced surgical time required, the number of complications is considered high. Moreover, due to a limited number of patients included in the case series and the short duration of follow-up, additional studies including a control group are required.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 4","pages":"411-422"},"PeriodicalIF":4.8,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143020689","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence in Detecting and Segmenting Vertical Misfit of Prosthesis in Radiographic Images of Dental Implants: A Cross-Sectional Analysis","authors":"Paniz Fasih,&nbsp;Amir Yari,&nbsp;Lotfollah Kamali Hakim,&nbsp;Nader Nasim Kashe","doi":"10.1111/clr.14406","DOIUrl":"10.1111/clr.14406","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>This study evaluated ResNet-50 and U-Net models for detecting and segmenting vertical misfit in dental implant crowns using periapical radiographic images.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Periapical radiographs of dental implant crowns were classified by two experts based on the presence of vertical misfit (reference group). The misfit area was manually annotated in images exhibiting vertical misfit. The resulting datasets were utilized to train the ResNet-50 and U-Net deep learning models. Then, 70% of the images were allocated for training, while the remaining 30% were used for validation and testing. Five general dentists categorized the testing images as “misfit” or “fit.” Inter-rater reliability with Cohen's kappa index and performance metrics were calculated. The average performance metrics of dentists and artificial intelligence (AI) were compared using the paired-samples <i>t</i> test.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>A total of 638 radiographs were collected. The kappa values between dentists and AI ranged from 0.93 to 0.98, indicating perfect agreement. The ResNet-50 model achieved accuracy and precision of 92.7% and 87.5%, respectively, whereas dentists had a mean accuracy of 93.3% and precision of 89.6%. The sensitivity and specificity for AI were 90.3% and 93.8%, respectively, compared to 90.1% and 95.1% for dentists. The Dice coefficient yielded 88.9% for the ResNet-50 and 89.5% among the dentists. The U-Net algorithm produced a loss of 0.01 and an accuracy of 0.98. No significant difference was found between the average performance metrics of dentists and AI (<i>p</i> &gt; 0.05).</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>AI can detect and segment vertical misfit of implant prosthetic crowns in periapical radiographs, comparable to clinician performance.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 5","pages":"578-588"},"PeriodicalIF":4.8,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Accuracy, Surgical Time, and Learning Curve of Freehand, Static, and Dynamic Computer-Assisted Implant Surgery in an In Vitro Study","authors":"Joscha Gabriel Werny,&nbsp;Shengchi Fan,&nbsp;Leonardo Diaz,&nbsp;Bilal Al-Nawas,&nbsp;Keyvan Sagheb,&nbsp;Matthias Gielisch,&nbsp;Eik Schiegnitz","doi":"10.1111/clr.14403","DOIUrl":"10.1111/clr.14403","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p>This experimental study compared the accuracy of implant insertion using the free-hand (FH) technique, static computer-aided surgery (S-CAIS), or dynamic computer-assisted surgery (D-CAIS) and to evaluate the correlation of learning curves between surgeons' experience and surgical time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Thirty-six models were randomly assigned to three groups (FH, <i>n</i> = 12; S-CAIS, <i>n</i> = 12; D-CAIS, <i>n</i> = 12). Each model was planned to receive four implants in the maxillary anterior and posterior regions. Twelve participants, six experienced surgeons, and six dental students were included in this study. The primary outcome was the deviation between the planned and final implant placement from each group. Secondary outcomes were each technique's learning curve regarding surgical time.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>The average deviation at implant platform, apex and gradual deviation with FH technique were 1.31 ± 0.88 mm, 1.75 ± 0.9 mm and 6.67° ± 3.70°, respectively. The average deviation of implant platform, apex and angular in S-CAIS were 0.67 ± 0.32 mm, 1.00 ± 0.39 and 2.66° ± 1.77°, respectively. The average deviation of implant platform, apex and angular in D-CAIS were 1.14 ± 0.70 mm, 1.23 ± 0.58 and 3.20° ± 2.16°, respectively. Significant discrepancies at the implant platform, implant apex, and angular deviation were found between all surgical methods (<i>p</i> &lt; 0.016). Learning curves were evident after multiple implant insertions using both freehand and S-CAIS.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>The findings indicate that computer-assisted implant insertion leads to a more precise implant alignment than implants inserted freehand in an experimental set-up.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 5","pages":"555-565"},"PeriodicalIF":4.8,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14403","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction of Peri-Implant Buccal Bone Dehiscence Following Sub-Periosteal Peri-Implant Augmented Layer Technique With Either Block or Particulate Xenograft: A Retrospective Study","authors":"Mattia Severi,&nbsp;Franzini Chiara,&nbsp;Anna Simonelli,&nbsp;Chiara Scapoli,&nbsp;Leonardo Trombelli","doi":"10.1111/clr.14400","DOIUrl":"10.1111/clr.14400","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>To evaluate the effectiveness of Sub-periosteal Peri-implant Augmented Layer (SPAL) technique performed with deproteinized bovine bone mineral (DBBM), delivered either as particulate (pDBBM) or block (bDBBM), in correcting a peri implant bone dehiscence (PIBD). Implants showing a thick (≥ 2 mm) peri-implant buccal bone plate (PBBP) at placement were also examined.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Material and Methods</h3>\u0000 \u0000 <p>Patients with a PIBD ≥ 1 mm, treated with SPAL with either pDBBM (SPAL_particulate) or bDBBM (SPAL_block), and patients with an implant showing a PBBP ≥ 2 mm at insertion (CONTROL) were included. Re-entry was performed either at 6 months (SPAL groups) or 3 months (CONTROL). The rate of patients presenting no PIBD at re-entry was the primary outcome. Bone dehiscence height (BDH) and width (BDW), thickness of buccal tissues (BTT) and marginal bone level (MBL) were secondary outcomes.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Thirty-nine implants in 39 patients (14 in SPAL_particulate,14 in SPAL_block and 11 in CONTROL) were analyzed. No PIBD were found in SPAL_particulate whereas in SPAL_block one PIBD was present. Two patients in CONTROL presented a PIBD. A reduction in both BDH and BDW was observed in both SPAL_particulate (2.7 ± 1.6 mm for BDH and 3.9 ± 0.2 mm for BDW) and SPAL_block (2.5 ± 1.8 mm for BDH and 3.8 ± 1.1 mm for BDW). SPAL_block showed a higher BTT than SPAL_particulate at re-entry (3.6 ± 1.3 mm for SPAL_block and 2.6 ± 0.6 mm for SPAL_particulate, <i>p</i> = 0.0160). All groups showed similar MBL.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>SPAL performed with either a pDBBM or bDBBM is similarly effective in correcting a PIBD as well as in increasing BTT.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 4","pages":"481-493"},"PeriodicalIF":4.8,"publicationDate":"2025-01-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14400","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dental Implant Rehabilitation in Patients Carrying WNT10A Mutations With Different Molecular Statuses and Phenotypes: A Retrospective Cohort Study","authors":"Jiaqi Dou,&nbsp;Qinggang Dai,&nbsp;Xinbo Yu,&nbsp;Yining He,&nbsp;Yuwei Dai,&nbsp;Feng Wang,&nbsp;Yiqun Wu","doi":"10.1111/clr.14402","DOIUrl":"10.1111/clr.14402","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objectives</h3>\u0000 \u0000 <p><i>WNT10A</i> mutations are associated with tooth agenesis. This study aimed to assess the clinical outcomes of dental implants in patients carrying <i>WNT10A</i> mutations with different molecular statuses and phenotypes over a long-term follow-up period.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Materials and Methods</h3>\u0000 \u0000 <p>Patients with tooth agenesis were screened by whole-exome sequencing (WES) from January 2010 to September 2023. Carriers of pathogenic <i>WNT10A</i> mutations who underwent subsequent dental implant therapy were evaluated.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>WES identified 66 patients with tooth agenesis carrying <i>WNT10A</i> mutations. Of these, 27 patients (11 males/16 females; mean age 19.6 years) met the inclusion criteria. Homozygotes had significantly more missing teeth (24.4 ± 3.8) than heterozygotes (10.9 ± 5.1, <i>p</i> &lt; 0.0001) and compound heterozygotes (13.8 ± 3.5, <i>p</i> = 0.001). A total of 160 conventional implants were placed. Seven implants were lost in four patients before final prosthesis placement, resulting in overall failure rates of 14.8% at the subject level and 4.4% at the implant level. The 5-year cumulative survival rate (range: 0.23–12.74 years) was 85.2% and 95.6% at the subject and implant levels, respectively. The mean marginal bone loss (MBL) was 0.80 mm (95% CI: 0.59–1.02). Subgroup analysis revealed higher MBL in homozygotes (<i>p</i> = 0.002), sites requiring extensive bone augmentation (<i>p</i> = 0.016), anterior regions (<i>p</i> = 0.031), and full-arch bridge cases (<i>p</i> &lt; 0.0001). Patient satisfaction and OHIP-C49 scores were favorable.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusions</h3>\u0000 \u0000 <p>Implant rehabilitation is predictable for patients with <i>WNT10A</i> mutations. However, increased MBL observed in homozygotes with severe tooth agenesis and in cases requiring extensive alveolar bone augmentation highlights the importance of genetic diagnosis prior to implant therapy in patients with severe tooth agenesis.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 4","pages":"505-517"},"PeriodicalIF":4.8,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14402","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142988541","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"NOTIFICATION: Human Fetal Osteoblast Behavior on Zirconia Dental Implants and Zirconia Disks With Microstructured Surfaces. An Experimental In Vitro Study","authors":"","doi":"10.1111/clr.14395","DOIUrl":"10.1111/clr.14395","url":null,"abstract":"<p>NOTIFICATION: Delgado-Ruíz, R. A., G. Gomez Moreno, A. Aguilar-Salvatierra, A. Markovic, J. E. Mate-Sánchez, and J. L. Calvo-Guirado. 2016. “Human Fetal Osteoblast Behavior on Zirconia Dental Implants and Zirconia Disks With Microstructured Surfaces. An Experimental in Vitro Study,” <i>Clinical Oral Implants Research</i> 27, no. 11: e144–e153. https://doi.org/10.1111/clr.12585.</p><p>This notification is for the above article, published online on 25 March 2015 in Wiley Online Library (wileyonlinelibrary.com), and has been issued by agreement between the journal Editor-in-Chief, Lisa J. A. Heitz-Mayfield; and John Wiley &amp; Sons Ltd.</p><p>The notification has been agreed in response to third-party concerns regarding the prior publication of image elements and data in Figure 5 and Table 4. The corresponding author has clarified that this data was previously published as a summary of the study's preliminary findings in a non-scholarly journal 1. However, following an editorial review, it was determined that the article provides sufficient new findings to justify publication. Therefore, the journal has decided to issue this notification to inform and alert the readers.</p><p>\u0000 <b>Reference</b>\u0000 </p><p>1 Valoración de la adherencia celular sobre implantes de zirconio modificados por láser de femtosegundo. (Extracto del trabajo ganador del “Premio Dr. Manuel Serrano Martínez” 2010) <i>Impresiones</i>, pages 25-31.</p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 3","pages":"410"},"PeriodicalIF":4.8,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14395","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142974585","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abaloparatide Enhances Bone Regeneration in Extraction Socket Dental Implant Defects: An Experimental In Vivo Study","authors":"Jessica Latimer,&nbsp;Birtan Yilmaz,&nbsp;Balazs Feher,&nbsp;Takahiko Shiba,&nbsp;Tobias Fretwurst,&nbsp;Bruce Mitlak,&nbsp;Beate Lanske,&nbsp;Paul Kostenuik,&nbsp;William V. Giannobile","doi":"10.1111/clr.14397","DOIUrl":"10.1111/clr.14397","url":null,"abstract":"<div>\u0000 \u0000 \u0000 <section>\u0000 \u0000 <h3> Objective</h3>\u0000 \u0000 <p>Abaloparatide (ABL) is a synthetic parathyroid hormone-related protein analog developed as an anabolic drug to treat osteoporosis. ABL increases bone mineral density (BMD) of the long bones and spine; however, the influence of ABL on alveolar bone regeneration remains unknown. This study assessed the effects of systemic ABL administration on tooth extraction socket healing and dental implant osseointegration in a preclinical rodent model.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Methods</h3>\u0000 \u0000 <p>Sprague-Dawley rats received daily subcutaneous injection of ABL (25 μg/kg) or vehicle (VEH) at the time of maxillary first molar (M1) extraction surgery; animals underwent either: (1) unilateral M1 extraction followed by sacrifice at 10 or 42d or (2) bilateral M1 extraction followed by staged implant placement in osteotomies with standardized defects and sacrifice at 21 or 28d.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Results</h3>\u0000 \u0000 <p>Micro-computed tomography (micro-CT) analysis demonstrated that ABL increased bone volume fraction (<i>p</i> = 0.004) and bone mineral density (BMD) (<i>p</i> = 0.006) of regenerated extraction sockets at 42d. Micro-CT of the femur validated systemic effects of ABL, showing greater trabecular BMD after 6 (<i>p</i> &lt; 0.01), 9 (<i>p</i> &lt; 0.001), and 14 (<i>p</i> &lt; 0.001) weeks of treatment. Histomorphometry confirmed a higher mineralized bone area with ABL treatment in extraction sockets at 42d (<i>p</i> = 0.03) and in the regenerated peri-implant bone at 21d post-implant placement (<i>p</i> = 0.01) compared to control.</p>\u0000 </section>\u0000 \u0000 <section>\u0000 \u0000 <h3> Conclusion</h3>\u0000 \u0000 <p>Systemic ABL administration enhances osteogenesis in extraction sockets prior to implant placement and accelerates peri-implant bone formation in the early phase of healing in the present rodent model.</p>\u0000 </section>\u0000 </div>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 4","pages":"471-480"},"PeriodicalIF":4.8,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142945902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Additional Cover","authors":"","doi":"10.1111/clr.14399","DOIUrl":"10.1111/clr.14399","url":null,"abstract":"<p>The inside back cover image is based on the Original article <i>Comparison of Different Intraoral Scanners With Prefabricated Aid on Accuracy and Framework Passive Fit of Digital Complete-Arch Implant Impression: An In Vitro Study</i> by Xiao-Meng Zhang et al., https://doi.org/10.1111/clr.14353.\u0000\u0000 <figure>\u0000 <div><picture>\u0000 <source></source></picture><p></p>\u0000 </div>\u0000 </figure></p>","PeriodicalId":10455,"journal":{"name":"Clinical Oral Implants Research","volume":"36 1","pages":"ii"},"PeriodicalIF":4.8,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/clr.14399","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142935093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}