Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Tranexamic Acid for the Treatment of Hyperpigmentation and Telangiectatic Disorders Other Than Melasma: An Update.","authors":"Tianyu Chen, Jing Xue, Qian Wang","doi":"10.2147/CCID.S479411","DOIUrl":"10.2147/CCID.S479411","url":null,"abstract":"<p><p>Tranexamic acid (TXA), a synthetic lysine analog, is a commonly used antifibrinolytic and procoagulant agent. Based on its good hemostatic efficacy, it is mainly used clinically for bleeding in trauma, various types of surgical and dental procedures and prevention of bleeding in patients with hemophilia. In recent years, studies have shown that TXA has the effects of anti-melanogenesis, anti-inflammation, anti-angiogenesis and promotes the recovery of the skin barrier, so it has been tried to be used as a treatment for hyperpigmentation and telangiectatic diseases. Oral, topical, intradermal injections and microneedling are all commonly used modes of administration. TXA for melasma is the most studied and has achieved indications in some countries, whereas it is still an off-label drug for many other dyschromia. We review the clinical use of TXA in hyperpigmentation and telangiectatic disorders other than melasma, such as post-inflammatory hyperpigmentation, Riehl's melanosis, rosacea, and post-acne erythema, to provide more evidence for the use of TXA in these disorders, and to provide safer and more cost-effective alternatives for the treatment of these diseases.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439988/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342956","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Identification of Upregulating Genes, Transcription Factors, and miRNAs in Vitiligo. In silico Study.","authors":"Ahmed Ibrahim AbdElneam, Mohammed Saleh Al-Dhubaibi, Saleh Salem Bahaj, Ghada Farouk Mohammed, Lina Mohammed Atef","doi":"10.2147/CCID.S480990","DOIUrl":"https://doi.org/10.2147/CCID.S480990","url":null,"abstract":"<p><strong>Background: </strong>Depigmentation of specific areas of the skin is a persistent and long-lasting dermatologic disorder known as vitiligo, stemming from the impairment and disruption of melanocytes both structurally and functionally, leading to the loss of pigmentation in those regions.</p><p><strong>Aim: </strong>Our objective was to identify the pivotal genes and upstream regulators, transcription factors (TFs), microRNAs (miRNAs), and pathways implicated in the pathogenesis of vitiligo.</p><p><strong>Methods: </strong>An integrated analysis was conducted using microarray datasets on vitiligo obtained from the Gene Expression Omnibus (GEO) database. The functional annotation and potential pathways of differentially expressed genes (DEGs) were additionally investigated through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) enrichment analyses. Various bioinformatics approaches were utilized, making use of publicly accessible databases to identify appropriate TFs and miRNAs.</p><p><strong>Results: </strong>Our investigation identified TYR, MLANA, TYRP1, PMEL, OCA2, SLC45A2, GPR143, DCT, TRPM1, and EDNRB as the most appropriate genes associated with vitiligo. Our suggestion is that the identified biological processes include developmental pigmentation (GO:0048066) and pigment metabolic processes (GO:0042440) as the most suitable biological processes. In contrast, the KEGG pathways that showed significance in our analysis are Tyrosine metabolism (Path: hsa00350) and Melanogenesis (Path: hsa04916). We hypothesized the involvement of ten TFs and 73 miRNAs in the regulation of genes related to vitiligo.</p><p><strong>Conclusion: </strong>TYR, MLANA, TYRP1, PMEL, OCA2, SLC45A2, GPR143, DCT, TRPM1, and EDNRB are the top ten genes that are pivotal in the progression and exhibition of vitiligo. The biological, cellular, molecular, and KEGG pathways of those genes has an imperative role in the pathogenesis of vitiligo. TFs and miRNAs that interact with this gene are listed, shedding light on the regulatory mechanisms governing the expression of these key genes in vitiligo.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11439351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Psoriasis and Pseudohernia of the Abdominal Wall at the Site of Herpes Zoster-Wolf's Isotopic Response.","authors":"Liwei Feng, Pei Liu, Meilin Huang, Linjie Tian, Xiaolin Bu","doi":"10.2147/CCID.S482555","DOIUrl":"https://doi.org/10.2147/CCID.S482555","url":null,"abstract":"<p><p>The patient, a 77-year-old Asian male presented with herpes zoster in the left lumbar and abdominal regions 9 weeks before presentation. The infection dried up after 2 weeks but was followed by an erythematous scaly rash in the same region with left-sided abdominal elevation. Pathological examination revealed continuous parakeratosis and Munro microabscesses. Abdominal computer tomography revealed no abnormalities, suggesting psoriasis with herpes zoster and Wolf's isotopic response to the pseudohernia of the abdominal wall.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11430214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342952","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unveiling the Hidden Dangers: Massive Allergic Dermatitis After Hyaluronic Acid Injection.","authors":"Fengfeng Guo, Yuxi Xia, Qingqian Wei, Jun Zhuang, Jinge Li, Jintian Hu","doi":"10.2147/CCID.S477847","DOIUrl":"https://doi.org/10.2147/CCID.S477847","url":null,"abstract":"<p><p>The increasing use of hyaluronic acid (HA) implants has made adverse effects more apparent. Here, we present a rare case of massive allergic dermatitis due to HA injections. We performed dermoscopy and color ultrasound, which clarified that this was an allergic dermatitis caused by fillers, and analyzed the possible causes of the allergy. Common treatments were compared, and the advantages of 5-FU-based treatment regimens and their associated mechanisms were noted. A low dose of 5-fluorouracil and triamcinolone acetonide was administered to the patient's entire face and neck, and significant efficacy was achieved. We aimed to gather evidence on extensive dermatitis caused by HA injection, provide new perspectives and solutions for subsequent HA injections, and promote further research on the potential mechanisms of extensive skin inflammation and allergies caused by local HA injections.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11430385/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of 1060 nm Diode Laser for Non-Invasive Subcutaneous Fat Reduction in Mini-Pigs.","authors":"Yea-Jin Lee, Namgue Hong, Eun Seo Choi, Sun-Hyang Choi, Eun Young Kim, Hyeong Ju Park, Jin-Chul Ahn","doi":"10.2147/CCID.S471367","DOIUrl":"https://doi.org/10.2147/CCID.S471367","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the efficacy and safety of abdominal fat reduction in mini-pigs, utilizing at 1060 nm diode laser with a wavelength of 1060 nm.</p><p><strong>Patients and methods: </strong>The laser system non-invasively disrupts adipose tissue; its effectiveness and safety were evaluated by ultrasound imaging and histological analysis. Laser irradiation was performed with various powers, and the cooling function was activated to prevent skin surface damage.</p><p><strong>Results: </strong>The dermal tissue temperature increased to at least 43°C during laser exposure, leading to a decrease in abdominal fat thickness after 30 days. Blood tests revealed no significant changes in kidney and liver function but showed increased blood levels of nonessential free acids (NEFAs), likely due to the release of fatty tissue-derived free fatty acids. Histological evaluation demonstrated rapid transformation of adipose tissue into collagen, muscle fibers, and intracellular fibrous tissue.</p><p><strong>Conclusion: </strong>The 1060 nm laser showed promise as a non-invasive and safe tool for reducing abdominal fat.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11421435/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Relationship of Skin Microbiota on Psoriasis: A Mendelian Randomization Study","authors":"Yangjia Chen, Zhaocheng Zhuang, Zhixiang Rao","doi":"10.2147/ccid.s484366","DOIUrl":"https://doi.org/10.2147/ccid.s484366","url":null,"abstract":"<strong>Objective:</strong> Epidemiological investigations have indicated an association between skin microbiota imbalance and psoriasis, however, the causal relationship has not been confirmed through Mendelian randomization (MR). MR employed genetic instrumental variables (IVs) to evaluate the causal relationship between skin microbiota and psoriasis, providing new insights for potential treatments.<br/><strong>Methods:</strong> Summary statistics for psoriasis and related traits were available from FinnGen R10 and United Kingdom Biobank (UKB) consortium. The genome-wide association studies (GWAS) on skin microbiota in three skin microenvironments came from two population-based German cohorts. Several selection processes were used to determine the optimal instrumental variables. Five MR methods were performed and different sensitivity analyses approaches yield robustness evidence under different assumptions.<br/><strong>Results:</strong> 449 SNPs were employed as IVs for 53 bacterial genera, with F-statistics between 20.18 and 42.44, indicating no evidence of weak instrument bias. <em>Bacteroides</em> was associated with psoriasis from UKB in IVW (OR, 95% CI: 0.914, 0.869– 0.961; <em>P</em> &lt; 0.001, P_B-H = 0.007). The taxon was also associated with psoriasis vulgaris (IVW: OR, 95% CI, 0.918, 0.872– 0.967; <em>P</em> = 0.001, <em>P</em>_B-H = 0.054) and psoriasis and related disorders (IVW: OR, 95% CI, 0.915, 0.875– 0.957; <em>P</em> &lt; 0.001, <em>P</em>_B-H = 0.008). Consistent causal estimates were identified in terms of both magnitude and direction, indicating a protective effect of <em>Bacteroides</em>.<br/><strong>Conclusion:</strong> The MR study found that <em>Bacteroides</em> in the antecubital fossa may protect against psoriasis, offering genetic proof that skin microbiota helps prevent the condition.<br/><br/><strong>Keywords:</strong> skin microbiota, psoriasis, Mendelian randomization, genus <em>Bacteroides</em>, autoimmune disease, AD<br/>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253488","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photodynamic Therapy for Condyloma Acuminatum and Cervical Intraepithelial Neoplasia Grade I in a Young Female Patient with Systemic Lupus Erythematosus: A Case Report","authors":"Na Zhang, Hongping Ge, Xinru Chen, Tianhui Ye, Weikang Shi, Meiyan Wang","doi":"10.2147/ccid.s479720","DOIUrl":"https://doi.org/10.2147/ccid.s479720","url":null,"abstract":"<strong>Abstract:</strong> Condyloma acuminatum (CA), commonly known as anogenital warts, is a prevalent sexually transmitted disease primarily caused by low risk human papillomavirus (HPV) types 6 and 11. This case report outlines the successful use of photodynamic therapy (PDT) to treat extensive condyloma acuminatum in a young female patient with systemic lupus erythematosus (SLE) undergoing immunosuppressive treatment. The patient also had cervical intraepithelial neoplasia grade I. Carbon dioxide laser treatment were initially used to remove some surface warts, followed by PDT, resulting in satisfactory outcomes. After seven sessions, the warty growths were successfully removed. Interdisciplinary collaboration, involving rheumatology, gynecology, and dermatology, facilitated comprehensive management. This case highlights the efficacy and safety of PDT in treating condyloma acuminatum and suggests its potential as an alternative treatment for young SLE patients with similar conditions.<br/><br/><strong>Keywords:</strong> condyloma acuminatum, photodynamic therapy, systemic lupus erythematosus<br/>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Causal Relationship Between Sex Hormones and Basal Cell Carcinoma: A Two-Sample Mendelian Randomization Study","authors":"Pan Luo, Dejin Gao, Chenglong Wang, Rui Guo, Qingguo Zhang","doi":"10.2147/ccid.s479500","DOIUrl":"https://doi.org/10.2147/ccid.s479500","url":null,"abstract":"<strong>Background:</strong> The primary aim of this study was to explore whether sex hormones affect the occurrence of basal cell carcinoma (BCC) from a genetic perspective using a two-sample Mendelian randomization (MR) study.<br/><strong>Methods:</strong> Exposure and outcome data for this MR analysis were derived from previously published GWAS studies. In this study, estradiol, sex hormone-binding globulin (SHBG), bioavailable testosterone, and total testosterone were used as exposures, and BCC was used as the outcome for the two-sample MR analysis. The random effects inverse variance weighted (IVW) model was the primary analytical model, and the simple mode, weighted median, MR-Egger, and weighted mode methods were applied as complementary approaches. Furthermore, the “leave-one-out” sensitivity analysis was performed to assess stability, Cochran’s Q test to evaluate heterogeneity, and the MR-Egger intercept test to analyze horizontal multiplicity.<br/><strong>Results:</strong> The two-sample MR analysis of the sex hormone and BCC showed that estradiol, sex hormone-binding globulin (SHBG), bioavailable testosterone, and total testosterone were not a causal factor in BCC (P&gt; 0.05). The results of the heterogeneity test and horizontal pleiotropic analysis showed that no heterogeneity or horizontal pleiotropic existed in all MR analyses (Cochran’s Q-P&gt; 0.05, Egger intercept-P&gt; 0.05).<br/><strong>Conclusion:</strong> The two-sample MR analysis showed that estrogen and testosterone did not affect the occurrence and development of BCC at the genetic level.<br/><br/>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142253490","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Turn Your AART into a HIT Using a Complete Range of Aesthetic Injectables: Methodology for Combining Products to Maximise Patient Outcomes","authors":"Andreas Nikolis, Luiz Eduardo Toledo Avelar, Alessandra Haddad, Stephanie Chuk Kwan Lam, Andrei Metelitsa, Heidi B Prather, Frank Rosengaus, Kaitlyn M Enright, Desislava Ognyanova Lazarova, Inna Prygoya, Fabio Iachetti","doi":"10.2147/ccid.s465155","DOIUrl":"https://doi.org/10.2147/ccid.s465155","url":null,"abstract":"<strong>Purpose:</strong> Optimizing outcomes of aesthetic treatments with injectable products usually requires a consideration of the entire face to ensure balance, along with combination treatments that align with the patient’s goals. To help injectors, a method of assessing the patient and developing an individualized, holistic treatment plan was developed. This methodology is termed Assessment, Anatomy, Range, and Treatment (AART™) and Holistic Individualized Treatments (HITs™). This article aims to describe and evaluate the novel and systematic AART-HIT™ methodology.<br/><strong>Methods:</strong> The AART-HIT™ methodology, including its associated diagnostic tool the Facial Assessment Scale (FAS™), were developed to aid injectors in completing a patient assessment in which the entire face is evaluated, the relevant anatomy is considered, the science behind the available range of products is understood, and the treatment plan is individualised for the patient. Specifically, the HITs™ are methodologic tools for practitioners to perform a standardized, full facial assessment and to create an individualized treatment approach to holistically address a patient’s aesthetic concerns. The use of this methodology in clinical practice was assessed via a survey, deployed to twenty-eight clinicians.<br/><strong>Results:</strong> Over 85% of participants agreed that the AART-HIT™ methodology was adequate for their needs. Additionally, 100% of participants agreed that the temporal sequencing of HITs™ and the FAS™ diagnostic tool was useful in clinical practice. Furthermore, over 70% of participants agreed that the anatomical locations identified in each HIT™ were sufficient, while over 80% responded that the HITs™ adequately represented the range of products. Finally, over 85% of participants agreed that the HITs™ covered different ethnic skin types and various patient ages and, over 80% of participants responded that they would not add additional elements to any of the 5 HITs™.<br/><strong>Conclusion:</strong> The AART-HIT™ methodology, including the FAS™ were comprehensive enough for clinical use in providing a personalised treatment plan for individual patients.<br/><br/><strong>Keywords:</strong> fillers, biostimulators, neuromodulators, hyaluronic acid, education, treatment techniques<br/>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142179885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erythema Papulatum Centrifugum: A Case Report of an Underrecognized Annular Erythema","authors":"Narikun Ketprapakorn, Poonkiat Suchonwanit","doi":"10.2147/ccid.s481193","DOIUrl":"https://doi.org/10.2147/ccid.s481193","url":null,"abstract":"<strong>Abstract:</strong> Erythema papulatum centrifugum (EPC), also known as erythema papulosa semicircularis recidivans, is a rare dermatological condition characterized by single or multiple annular or semi-annular centrifugally growing lesions surrounded by tiny erythematous papules typically observed on the trunk. EPC is prevalent, particularly in Japan and China, although only a few cases have been reported outside Asia. Herein, we present the case of a 47-year-old female from Thailand who experienced a pruritic annular erythematous rash on her right arm for two months. The diagnosis of EPC was established based on clinical manifestations and confirmed by histopathological examination. The lesions resolved after one month of treatment with 0.1% betamethasone valerate cream and avoiding warm weather. This case report contributes to the understanding of EPC, which may be underrecognized in clinical practice due to its self-limiting nature and frequent misdiagnosis. Furthermore, this article provides a comprehensive review of 17 previously reported cases of EPC, focusing on their detailed descriptions.<br/><br/><strong>Keywords:</strong> annular erythema, annular lesion, eccrine sweat gland, figurate erythema, perieccrine inflammation, sweating<br/>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142179887","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}