Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Koebner Phenomenon Is an Indicator of Vitiligo Activity and Aggression [Letter].","authors":"Yingjian Tan, Yue Zeng, Rui Li","doi":"10.2147/CCID.S522969","DOIUrl":"10.2147/CCID.S522969","url":null,"abstract":"","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"443-444"},"PeriodicalIF":1.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention and Management of Complications With a Hyaluronic Acid-Calcium Hydroxyapatite Hybrid Injectable.","authors":"Wolfgang G Philipp-Dormston, Koenraad De Boulle, David B Eccleston, Rachna Murthy, Karim Sayed, Philippe Snozzi, Fernando Urdiales-Galvez","doi":"10.2147/CCID.S506038","DOIUrl":"10.2147/CCID.S506038","url":null,"abstract":"<p><strong>Background: </strong>A ready-to-use hyaluronic acid-calcium hydroxyapatite (HA-CaHA) hybrid injectable has a dual mode of action for soft-tissue augmentation. Although previous studies have reported a favorable safety profile for HA-CaHA, there is a need for guidelines and recommendations based on real-world clinical experience for the management of complications associated with HA-CaHA.</p><p><strong>Purpose: </strong>This publication provides guidelines and recommendations for the prevention and management of HA-CaHA-related complications. A case study example, treatment algorithms, and injection techniques are included to illustrate the management of complications.</p><p><strong>Materials and methods: </strong>On January 25, 2023, 13 European physicians were invited to an advisory board meeting to discuss strategies for optimizing patient care, minimizing adverse events (AEs), and identifying data gaps for the prevention and management of complications with HA-CaHA.</p><p><strong>Results: </strong>The management of a subset of AEs, including skin discoloration and edema, was discussed. Small group workshops also shared management algorithms for late noninflammatory adverse reactions, late inflammatory adverse reactions, localized vascular complications, and retinal vascular complications. Best practices for optimal injection techniques were discussed, and injection-technique protocols were developed for treatment sites. Treatment strategies for HA-CaHA-related complications are considered similar to treatment of those resulting from single-agent fillers, and knowledge of anatomy, aseptic technique, correct injection techniques, and appropriate posttreatment care is emphasized.</p><p><strong>Conclusion: </strong>These recommendations on the management of HA-CaHA-related complications may serve as a reference for the broad range of clinicians using HA-CaHA hybrid injectable for different indications and can help optimize patient outcomes and safety.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"431-441"},"PeriodicalIF":1.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Trends and Associations of Chilblains Prevalence with Connective Tissue Diseases, Including COVID-19 Incidence\" [Letter].","authors":"Yingjian Tan, Rui Li","doi":"10.2147/CCID.S521256","DOIUrl":"10.2147/CCID.S521256","url":null,"abstract":"","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"417-418"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermatosis Neglecta and Chilblain Lupus Erythematosus Occurred Post Surgery of Basal Cell Carcinoma: A Case Report.","authors":"Guomin Gao, Jiayun Liu, Rui Sun, Xuankai Liu, Dan Meng, Weiyuan Ma","doi":"10.2147/CCID.S509485","DOIUrl":"10.2147/CCID.S509485","url":null,"abstract":"<p><p>Dermatosis neglecta (DN) is a rare condition, often linked to psychosomatic disorders, with an unclear etiology. Chilblain lupus erythematosus (CHLE) constitutes a rare variant of cutaneous lupus erythematosus, frequently mistaken for idiopathic chilblain due to its chilblain-like lesions. To date, no instances of concurrent DN and CHLE occurring at the site of a skin flap or graft have been documented. Herein, we present a case that the occurrence of DN and CHLE developed on a skin flap at once. The simultaneous occurrence of DN and CHLE on a skin flap is exceptionally rare. Clinicians must exercise heightened vigilance due to the common misdiagnosis of CHLE. Various skin disorders can manifest on skin flaps and grafts post-transplantation. Thus, clinicians must remain vigilant for both recurrence and metastasis during post-operative monitoring, while also attending to patients' mental well-being and the condition of skin flaps.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"419-426"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Types and Characteristics of Hair Across the Globe: Results of a Multinational Study on 19,461 Individuals.","authors":"Frederic Flament, Aurelie Maudet, Philippe Barbarat, Meriem Jabnoun, Muriel Bayer-Vanmoen, Audrey Imbert Legrain, Stephanie Leclerc-Mercier, Charles Taieb, Charbel Skayem, Laurence Lebarbanchon","doi":"10.2147/CCID.S377009","DOIUrl":"10.2147/CCID.S377009","url":null,"abstract":"<p><strong>Introduction: </strong>Hair plays a critical role in enhancing physical appearance, self-esteem, and identity. However, the impact of hair characteristics on daily life has received limited attention. This study aimed to assess the types and characteristics of hair, their variations according to age, gender, ethnicity, and country, and their effects on individuals' daily lives.</p><p><strong>Methods: </strong>A study was conducted between February 2022 and June 2023 across nine countries: USA, France, Brazil, India, China, Mexico, Japan, South Africa, and Indonesia. A total of 19,461 participants aged 18 and older were selected using stratified, proportional sampling. Participants completed a structured digital questionnaire evaluating hair thickness, type, damage, and curl degree, alongside questions on stress, sleep, and well-being. Data were analyzed using descriptive statistics and statistical tests (<i>T</i>-test, Pearson's test).</p><p><strong>Results: </strong>Thin hair was reported by 23.7% of males and 29.2% of females. Dry hair was more common in females (38.9%) than males (32.1%). Damaged hair was reported by 47% of females and 30% of males. Ethnic differences showed that thick hair was most common in African (40.7%) and least in Asian (26.3%) populations. The impact of hair type on daily life varied significantly across countries. Individuals with damaged or dry hair experienced higher stress, lack of sleep, and poor well-being, especially in Japan, India, and France. Hair type (straight, wavy, curly, kinky) also affected personal and professional stress levels differently in each country.</p><p><strong>Conclusion: </strong>Our research shows that hair characteristics significantly influence daily life, self-image, and well-being, with notable variations by gender, ethnicity, and country. These findings highlight the need for interventions to address the psychological and social impacts of hair issues, contributing to better healthcare, body image, and product development.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"393-404"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Relationship Between Blood Metabolomics and Female Pattern Hair Loss: A Bidirectional Mendelian Randomization Study.","authors":"Lin Peng, Xu Zhao, Liangliang Shen, Lili Zhang, Yu Han, Lutong Li, Miao Jiang","doi":"10.2147/CCID.S494185","DOIUrl":"10.2147/CCID.S494185","url":null,"abstract":"<p><strong>Background: </strong>Metabolic disorders have been hypothesized to be associated with female-pattern hair loss. However, ambiguity persists regarding the causality and directionality of the relationship between blood metabolites and female hair loss patterns.</p><p><strong>Methods: </strong>To evaluate the causal relationship between 1400 blood metabolites and female pattern hair loss, we conducted a bidirectional Mendelian randomization analysis using publicly available summary data from genome-wide association studies. The primary analyses employed the inverse variance weighted method supplemented by the weighted median, MR-Egger, and weighted mode approaches. To control for multiple testing, the false discovery rate method was applied to adjust P values. The leave-one-out method was employed for the sensitivity analysis. Heterogeneity was evaluated using Cochran's Q value, whereas horizontal pleiotropy was assessed using MR-Egger intercept and MR-PRESSO. Additionally, metabolic pathway analysis was performed for the metabolites that demonstrated significant correlations. We further performed colocalization analysis to delve into the underlying causality.</p><p><strong>Results: </strong>After rigorous selection, 23 metabolites and 4 metabolic ratios were associated with female-pattern hair loss. There were no noticeable outliers, horizontal pleiotropy, or heterogeneity. Metabolic pathway analysis identified one significant pathway: fructose/mannose metabolism (P < 0.05). In the reverse analysis, dimethylglycine was identified as overlapping with the forward analysis results, thereby removing it from the final analysis.</p><p><strong>Conclusion: </strong>Through integration of genomic and metabolomic data, we identified blood metabolites that may be associated with the development of female pattern hair loss. Our findings provide novel insights into the pathogenic mechanisms of this condition. These findings have significant implications for early diagnosis, preventive measures, and treatment.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"383-392"},"PeriodicalIF":1.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cladribine Ameliorates Imiquimod Induced Murine Psoriasiform Dermatitis.","authors":"Jingwen Xue, Dan Shu, Yi Zhao","doi":"10.2147/CCID.S511351","DOIUrl":"10.2147/CCID.S511351","url":null,"abstract":"<p><strong>Background: </strong>Significant progress has been made in understanding the mechanisms of psoriasis, particularly the role of the interleukin (IL)-23/T-helper (Th) 17 axis, leading to novel, targeted therapies. However, many patients develop resistance to treatment over time. Thus, exploring new therapeutic strategies for severe refractory psoriasis remains crucial.</p><p><strong>Objective: </strong>To investigate the effect of cladribine on imiquimod induced psoriasiform dermatitis in mice.</p><p><strong>Methods: </strong>We established an imiquimod (IMQ)-induced psoriasiform dermatitis mouse model to investigate cladribine's effects on skin immune cells. Mice were allocated to five groups: Control, IMQ, High-dose cladribine (30mg/kg), Low-dose cladribine (20mg/kg), and Methotrexate. We assessed cumulative scores, skin pathology, immunohistochemistry, flow cytometry, and serum cytokines. We also studied cladribine's long-term efficacy by reapplying IMQ for a second round (7 days) after five half-lives of cladribine.</p><p><strong>Results: </strong>Cladribine significantly ameliorated symptoms and pathological features of IMQ-induced psoriasis in both high and low-dose groups, with efficacy comparable to methotrexate. Cladribine dose-dependently reduced Th17 and Th1 cell frequencies in psoriatic skin, along with associated cytokines. High-dose cladribine demonstrated sustained inhibition of IMQ-induced psoriasis.</p><p><strong>Conclusion: </strong>These findings indicate that cladribine can ameliorate imiquimod-induced psoriasiform dermatitis in mice, exhibiting a dose-dependent and sustained therapeutic effect.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"405-415"},"PeriodicalIF":1.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus Recommendations for the Reconstitution and Aesthetic Use of Poly-D,L-Lactic Acid Microspheres - Comment on the Facial Injection Techniques [Response to Letter].","authors":"Fabiano Nadson Magacho-Vieira","doi":"10.2147/CCID.S519851","DOIUrl":"10.2147/CCID.S519851","url":null,"abstract":"","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"381-382"},"PeriodicalIF":1.9,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus Recommendations for the Reconstitution and Aesthetic Use of Poly-D,L-Lactic Acid Microspheres - Comment on the Reason of \"Fast Reconstitution\" [Response to Letter].","authors":"Fabiano Nadson Magacho-Vieira","doi":"10.2147/CCID.S519991","DOIUrl":"10.2147/CCID.S519991","url":null,"abstract":"","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"379-380"},"PeriodicalIF":1.9,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restless Legs Syndrome in Psoriasis: A Multicenter Study on Its Prevalence, Severity, and Impact on Patients.","authors":"Chuyen Thi Hong Nguyen, Nguyet Huu Minh Nguyen, Trung The Van","doi":"10.2147/CCID.S502902","DOIUrl":"10.2147/CCID.S502902","url":null,"abstract":"<p><strong>Purpose: </strong>Psoriasis is a chronic inflammatory skin disease often associated with multiple comorbidities, including restless leg syndrome (RLS). However, the prevalence and impact of RLS on quality of life and clinical outcomes in patients with psoriasis remain underexplored, particularly in Asian populations. In this study, we compared the prevalence of RLS in patients with psoriasis and healthy controls and evaluated the association between RLS and quality of life, sleep disturbances, and clinical severity of psoriasis.</p><p><strong>Patients and methods: </strong>This multicenter, cross-sectional study involved 212 participants (106 patients with psoriasis and 106 healthy controls) and was conducted from March to July 2024 at three major hospitals in Ho Chi Minh City, Vietnam. RLS was diagnosed according to the International Restless Leg Syndrome Study Group (IRLSSG) criteria. The RLS severity, sleep quality, quality of life, and psoriasis severity were assessed using the Restless Legs Syndrome Rating Scale, Pittsburgh Sleep Quality Index, Dermatology Life Quality Index, and Psoriasis Area and Severity Index (PASI), respectively.</p><p><strong>Results: </strong>The prevalence of RLS was significantly higher in patients with psoriasis than in healthy controls. Patients with psoriasis and RLS exhibited significantly poorer sleep quality and a greater impact on quality of life than those without RLS. The RLS group exhibited a higher PASI score, indicating more severe psoriasis. A strong positive correlation was observed between PASI and RLS severity.</p><p><strong>Conclusion: </strong>RLS is significantly more prevalent in patients with psoriasis and is associated with worse sleep quality, greater impairment of quality of life, and increased psoriasis severity. Early screening for RLS in patients with psoriasis using the IRLSSG criteria may facilitate timely intervention and improve outcomes.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"367-378"},"PeriodicalIF":1.9,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}