Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"The Role of Biomechanical Forces in the Formation and Treatment of Pathological Scars.","authors":"Guangtong Cao, Mingmin Ye, Haiyan Wang, Yi Liu, Mengzhi Li","doi":"10.2147/CCID.S496253","DOIUrl":"10.2147/CCID.S496253","url":null,"abstract":"<p><p>Pathological scars, including hypertrophic scar and keloid are the result of excessive tissue repair and are influenced by biomechanical forces like tension, mechanical pressure, and stiffness. These forces significantly impact scar development and progression, affecting wound healing, collagen deposition, and tissue remodeling. Understanding how these mechanical stimuli contribute to scar development is essential for devising effective therapeutic interventions. Clinically, reducing wound tension and applying mechanical pressure are key strategies for managing pathological scars. Techniques like super-tension-reduction suturing, stress-shielding polymers, and force-modulating tissue bridges (FMTB) have been shown to effectively alleviate tension and reduce scar proliferation. Additionally, Pressure Garment Therapy (PGT) is widely used to treat hypertrophic scars by reducing tissue stiffness, limiting collagen buildup, and promoting collagen realignment. Despite challenges such as discomfort and uneven pressure application, ongoing research focuses on enhancing these therapies through mechanosensitive technologies to improve both efficacy and patient comfort. This review highlights the role of biomechanical forces in scar formation and discusses therapeutic approaches that target these forces to improve clinical outcomes.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2565-2571"},"PeriodicalIF":1.9,"publicationDate":"2024-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11570529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666442","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association Between Life's Essential 8 and Psoriasis in American Adults: A Cross-Sectional NHANES Study.","authors":"Weiqing Zhang, Zengze Yuan, Yihan Wang, Zhaokai Jin, Ziyue Luo, Xinchang Wang","doi":"10.2147/CCID.S476594","DOIUrl":"10.2147/CCID.S476594","url":null,"abstract":"<p><strong>Purpose: </strong>Life's Essentials 8 (LE8) is a new indicator developed by the American Heart Association to assess cardiovascular health, including diet, physical activity, nicotine exposure, sleep health, body mass index, blood lipids, blood glucose and blood pressure. And more and more studies have shown that this index can evaluate other diseases, such as chronic kidney disease, abdominal aortic calcification and so on. However, there is no relevant study to evaluate the association between LE8 and psoriasis. The purpose of this study was to investigate the relationship between LE8 and the prevalence of psoriasis in American adults.</p><p><strong>Patients and methods: </strong>The data are from the National Health and Nutrition Examination Survey (NHANES) of the United States from 2003 to 2006, 2009 to 2014. Psoriasis was the dependent variable. LE8 is an independent variable and is divided into three levels: high, medium and low. Multivariate logistic regression model was used to explore the relationship between LE8 and psoriasis.</p><p><strong>Results: </strong>A total of 13430 people were included in this study, including 391 patients with psoriasis and 13039 patients without psoriasis. The prevalence of psoriasis was 2.91%. In the fully adjusted logistic regression model, LE8 score was negatively correlated with psoriasis (OR=0.99; 95% CI, 0.98-0.99, P=0.0003). And this result still exists when LE8 is divided into high, medium and low groups. Compared with the low LE8 group, the high LE8 group had a 61% lower risk of psoriasis (OR=0.39; 95% CI, 0.26-0.57, p <0.0001).</p><p><strong>Conclusion: </strong>This cross-sectional study suggested that LE8 score was negatively correlated with psoriasis risk.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2555-2563"},"PeriodicalIF":1.9,"publicationDate":"2024-11-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11568770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646938","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment of Mid-Face Aging with Calcium Hydroxylapatite: Focus on Retaining Ligament Support.","authors":"Mauricio Sato, Mariana Muniz, Luis Ricardo Coelho Ferreira","doi":"10.2147/CCID.S468447","DOIUrl":"10.2147/CCID.S468447","url":null,"abstract":"<p><p>The mid-face has been rendered as the cornerstone of facial aesthetic improvement, since treating the mid-face has also beneficial effects on neighboring esthetic units and therefore should be one of the first areas to be assessed. Retaining ligaments (RL) bind soft tissue layers of the face to the underlying facial skeleton. It remains controversial whether RL suffers laxity with aging or if changes in 42 bone and other structures where ligaments are inserted lead to altered mechanical function of the latter. Enhancement of the supportive effect of the ligaments could help restore the soft tissues to their original anatomical positions and achieve a lifting effect. While injectable hyaluronic acid implants have been used to improve ligament support, calcium hydroxylapatite has one of the highest viscoelasticities when compared with other dermal fillers and can induce collagen synthesis, which could provide long-term laxity correction. In this preliminary report of a case series, our goal was to describe the use of calcium hydroxylapatite in different dilutions and combinations for different aging profiles to treat the midface as an alternative for hyaluronic acid injections and to describe the ultrasonographic behavior in the long run.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2545-2553"},"PeriodicalIF":1.9,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Relationship Between Angiotensin-Converting Enzyme Gene I/D Polymorphism and Psoriasis, Including Psoriasis with Comorbid Hypertension and Diabetes.","authors":"Jiayun Liu, Rui Sun, Guomin Gao, Mogen Zhang, Huiping Fan, Xiaonan Ma, Yanhong Yu, Yanmei Yuan, Lulu Zhang, Changying Niu","doi":"10.2147/CCID.S482663","DOIUrl":"10.2147/CCID.S482663","url":null,"abstract":"<p><strong>Objective: </strong>The relationship between angiotensin-converting enzyme (ACE) insertion/deletion (I/D) gene polymorphism and psoriasis remains unclear. This study aims to analyze the association between ACE gene I/D polymorphism and the risk of psoriasis vulgaris in the Chinese Han population and to examine the correlation between ACE gene I/D polymorphism and psoriasis with comorbid hypertension and diabetes.</p><p><strong>Methods: </strong>A total of 358 patients with psoriasis vulgaris and 347 age- and sex-matched healthy volunteers from the Chinese Han population were selected. Clinical data, including blood pressure and fasting blood glucose, were collected from the patients. The ACE gene I/D polymorphism was analyzed using polymerase chain reaction (PCR). The association between ACE gene I/D polymorphism and psoriasis vulgaris, as well as comorbid hypertension and diabetes, was analyzed using the Pearson <i>χ²</i>-test.</p><p><strong>Results: </strong>The frequency of the ACE II genotype (OR = 1.84, 95% CI = 1.30, 2.61; <i>P</i> < 0.01) and the I allele (OR = 1.51, 95% CI = 1.22, 1.86; <i>P</i> < 0.01) was significantly higher in psoriasis patients compared to the control group. Conversely, the frequency of the ACE DD genotype (OR = 0.62, 95% CI = 0.44, 0.87; <i>P</i> < 0.01) and the D allele (OR = 0.66, 95% CI = 0.54, 0.82; <i>P</i> < 0.01) was significantly lower in psoriasis patients compared to the control group. No statistically significant differences were observed when stratified by blood pressure and blood glucose abnormalities (<i>P</i> > 0.05).</p><p><strong>Conclusion: </strong>The ACE II genotype and I allele are risk factors for psoriasis vulgaris in the Northern Chinese Han population.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2537-2543"},"PeriodicalIF":1.9,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11566204/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142646949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating the Properties of a Dual-Effect Facial Injectable: From Preclinical Data to Real-World Evidence.","authors":"Patricia Ormiga, Claudia A Hernández, Rogério de Lima Romeiro, Aude Bernardin, Fabio Sambatti Crema, Lauren Nakab, Lital Shklanovsky, Graeme Kerson","doi":"10.2147/CCID.S474587","DOIUrl":"10.2147/CCID.S474587","url":null,"abstract":"","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2533-2536"},"PeriodicalIF":1.9,"publicationDate":"2024-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11562601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Non-HDL to HDL Cholesterol Ratio (NHHR) and Psoriasis in Adults: A Cross-Sectional Study Using 2009-2014 Data.","authors":"Yizi Jiang, Min Jia","doi":"10.2147/CCID.S492053","DOIUrl":"10.2147/CCID.S492053","url":null,"abstract":"<p><strong>Background: </strong>Because of its possible significance in metabolic diseases, the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) has garnered attention as a novel and trustworthy lipid biomarker. Psoriasis may be linked to metabolic problems and obesity, according earlier research. Uncertainty surrounds the relationship between NHHR and the onset of psoriasis, though. The primary aim of this investigation was to examine the relationship between NHHR and psoriasis.</p><p><strong>Patients and methods: </strong>This cross-sectional analysis used data from the National Health and Nutrition Examination Survey (NHANES) conducted between 2009 and 2014. The association between psoriasis and NHHR was examined using multivariate logistic regression, and smoothed curve fitting was done to explore the non-linear relationship. Furthermore, Subgroup and sensitivity studies were performed in order to confirm the robustness of the findings.</p><p><strong>Results: </strong>Psoriasis and NHHR were shown to be positively correlated in 15,951 adult individuals who were at least 20 years old. Psoriasis risk rose by 7% for each unit increase in NHHR [1.07 (1.01, 1.14)]. Individuals in the highest NHHR tertile were 39% more likely compared to those in the bottom tertile to have psoriasis [1.39 (1.09, 1.78)]. Across subgroups, this favorable connection remained consistent.</p><p><strong>Conclusion: </strong>Elevated NHHR levels are positively correlated with an upsurge chance of psoriasis in the adult population in the United States. The significance of NHHR as an indication for early psoriasis risk assessment is shown by this study.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2523-2531"},"PeriodicalIF":1.9,"publicationDate":"2024-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11561548/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unexpected Repigmentation of Vitiligo Universalis Following Hemodialysis Initiation: A Rare Case Report and Literature Overview.","authors":"Abdulaziz A Alnoshan, Fahad Hamoud Alrashdi, Rawan Abdulaziz AlDahash, Khalid Nabil Nagshabandi, Salman Alotaibi","doi":"10.2147/CCID.S482396","DOIUrl":"https://doi.org/10.2147/CCID.S482396","url":null,"abstract":"<p><p>Vitiligo is a chronic skin depigmentation disorder affecting 0.2-1.8% of the global population, with a significant prevalence in Saudi Arabia. Although not life-threatening, it severely impacts the quality of life and psychological well-being of patients. We report a rare instance of hemodialysis-induced skin repigmentation involving a 25-year-old woman with vitiligo universalis.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2519-2522"},"PeriodicalIF":1.9,"publicationDate":"2024-11-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11556327/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"FOXN3 Regulates Autophagic Activity to Suppress Drug Resistance in Melanoma Cells.","authors":"Yaqi Wang, Hui Su, Xiaopeng Wang, Chen Tu, Tong Xiao, Bincheng Ren, Shuang Wang","doi":"10.2147/CCID.S462854","DOIUrl":"https://doi.org/10.2147/CCID.S462854","url":null,"abstract":"<p><strong>Background: </strong>The forkhead box (FOX) family member FOXN3 has been reported to inhibit transcriptional activity associated with regulating tumor development. However, the role of FOXN3 in the pathogenesis of melanoma is not well understood.</p><p><strong>Objective: </strong>To investigate the biological functions of FOXN3 in drug resistance of melanoma.</p><p><strong>Materials and methods: </strong>The expression of FOXN3 in melanoma was investigated using Gene Expression profiling interactive analysis (GEPIA) and Linkedomics databases. Melanoma cell proliferation, invasion, and migration were assessed using the colony formation assay, the scratch wound healing test, the Transwell invasion assay, and the nude mice xenograft to determine the effects of FOXN3 over-expression and depletion. The functional role of the transcriptional regulator in melanoma cells was tested through chromatin immunoprecipitation, immunofluorescence.</p><p><strong>Results: </strong>FOXN3 was downregulated in melanoma. Over-expression of FOXN3 inhibited the proliferation and motility of melanoma cells, whereas FOXN3 knockdown significantly enhanced the proliferation and motility of melanoma cells. Overexpression of FOXN3 reduced autophagic activity in melanoma cells. Enhanced autophagic activity in drug-resistant melanoma cell lines is related to drug-sensitive cells, and significant differences in FOXN3 localization were observed when comparing melanoma cells that were sensitive and resistant to Vemurafenib. Additionally, FOXN3 has been identified as binding to the promoter region of the cancer antigen Fibrous Sheath Interacting Protein 1 (FSIP1), thereby regulating the expression of this gene.</p><p><strong>Conclusion: </strong>FOXN3 functions as an important regulator of the development and progression of Vemurafenib-resistant melanoma cells, partly owing to its binding to the <i>FISP1</i>. As such, FOXN3 may represent a relevant target for therapeutic interventions in patients suffering from drug-resistant melanoma.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2505-2518"},"PeriodicalIF":1.9,"publicationDate":"2024-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11552389/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"An Overview of Commonly Used Natural Alternatives for the Treatment of Androgenetic Alopecia, with Special Emphasis on Rosemary Oil.","authors":"Nouf F Bin Rubaian, Haya Fahad Abdulaziz Alzamami, Baraa Abdulrazack Amir","doi":"10.2147/CCID.S470989","DOIUrl":"https://doi.org/10.2147/CCID.S470989","url":null,"abstract":"<p><p>Androgenetic alopecia is a chronic dermatological condition in which genetically predisposed individuals undergo progressive hair loss secondary to the effects of circulating androgens. It has been well documented that dihydrotestosterone binds to the androgenic receptors prevalent in the scalp, thus inducing miniaturization of the hair follicle. To date, the only FDA approved medications for the treatment of androgenetic alopecia are finasteride and minoxidil. A plethora of studies have been conducted testing the efficacy of various herbal compounds, but additional research is needed to further establish the concrete efficacy of such natural remedies in treating androgenetic alopecia. Of late, rosemary oil has gained mass popularity as a promising natural alternative. This review article will not only provide a detailed background on this ancient herbal component but will additionally overview all other major herbal alternatives including peppermint oil, tea tree oil, green tea, pumpkin seed oil, saw palmetto, and lavender oil and will summarize the latest clinical studies, which have tested their efficacy for the management of androgenetic alopecia.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2495-2503"},"PeriodicalIF":1.9,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11549889/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Chronic Nature of Generalized Pustular Psoriasis [Podcast].","authors":"Boni Elewski, Mark G Lebwohl","doi":"10.2147/CCID.S501061","DOIUrl":"https://doi.org/10.2147/CCID.S501061","url":null,"abstract":"<p><p>Generalized pustular psoriasis (GPP) is a rare, chronic, inflammatory skin disease characterized by persistent symptoms and sudden flares of painful, sterile pustules, and may be accompanied by systemic inflammation. Ongoing symptoms of GPP can have a serious impact on patient quality of life, morbidity, and mortality, and severe flares may be life-threatening if left untreated. Guidelines have been developed for the treatment of GPP flares; however, health care professionals and patients are lacking guidance on the management of long-term, persistent symptoms of GPP. Spesolimab is the only FDA-approved treatment for GPP and is approved for use in adults and pediatric patients aged 12 years or older and weighing at least 40 kg. Spesolimab recently gained FDA approval as a subcutaneous injection to treat GPP when patients are not experiencing a flare. In this podcast episode, we discuss what is known about the chronic disease burden of GPP and how persistent symptoms affect quality of life when patients are not experiencing a flare. We address the need for treatment guidelines for chronic GPP and discuss the results of the EFFISAYIL^® 2 clinical trial, which led to the approval of the subcutaneous formulation of spesolimab to treat GPP when patients are not experiencing a flare. Finally, we discuss what can be done to improve the treatment of patients with chronic GPP, both while experiencing a flare, and while living with persistent symptoms.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2487-2493"},"PeriodicalIF":1.9,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11551722/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142616100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}