Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Progress in the Application of Molecular Hydrogen in Medical Skin Cosmetology.","authors":"Nan Guo, Yating Zhang","doi":"10.2147/CCID.S500255","DOIUrl":"10.2147/CCID.S500255","url":null,"abstract":"<p><p>Molecular hydrogen is a colorless, tasteless, biologically active small-molecule gas with reducing properties, demonstrating therapeutic and preventive effects across various human systems. Its mechanisms of action include selective antioxidation, anti-inflammatory effects, apoptosis inhibition, and the regulation of gene expression and signaling pathways. In the skin, molecular hydrogen reduces oxidative damage by scavenging free radicals and inhibiting oxidative stress, leading to improvements in texture and tone. It also regulates the inflammatory response, alleviating redness, itching, and discomfort, while promoting skin repair and regeneration. Moreover, hydrogen activates antioxidant enzymes in skin cells, boosting their antioxidant capacity and delaying aging. Clinical trials show that molecular hydrogen significantly improves conditions like acne, chloasma, and skin sensitivity. However, research in skin cosmetology remains in its early stages, with unanswered questions regarding mechanisms of action, optimal dosage, and long-term safety. Further investigation through clinical trials is essential for expanding its applications in this field. Molecular hydrogen holds significant promise in skin cosmetology, and as research and technology evolve, it is expected to drive innovations and breakthroughs in skin care. This review examines the therapeutic potential, mechanisms, and clinical applications of molecular hydrogen in skin cosmetology, addressing challenges and proposing pathways for future advancements in this field.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"511-523"},"PeriodicalIF":1.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Injectable Hyaluronic Gel System on Skin Microbiota, Skin Defense Mechanisms and Integrity (Ex vivo Study).","authors":"Aleksei Y Prokopov, Zarema I Gazitaeva, Anna N Sidorina, Laurent Peno-Mazzarino, Nikita Radionov, Anna O Drobintseva, Igor M Kvetnoy","doi":"10.2147/CCID.S491685","DOIUrl":"10.2147/CCID.S491685","url":null,"abstract":"<p><strong>Objective: </strong>The influence of injectable hyaluronic gels on skin's microbiota is unclear. As well, skin microbiota is a key factor modulating final effect of injectable gels. The ex-vivo study was aimed at alterations following hyaluronic acid injection into the dermis in non-sterile skin surface conditions.</p><p><strong>Methods: </strong>Ex vivo human skin explants in the presence or absence of either <i>S. epidermidis or S. aureus</i>, were treated with either control excipient (0.9% sodium chloride) or test product (Hyaluronic acid injectable S, HA-S). Bacterial analysis was performed, as well as skin structural integrity. Histological imaging and immunostaining analysis in the presence of skin markers: epidermal (CD1a, Toll-like receptor 2 (TLR2), Beta-defensin-3 (BD3), CCN1) and dermal (DC-SIGN, Decorin) were then performed.</p><p><strong>Results: </strong>The injection of control excipient E and test product P, both associated with bacterial deposits, induced similar noticeable increase of <i>S. epidermidis</i> growth over 4 days, but no noticeable effect on growth of S. aureus. The injection of control excipient, associated with bacterial deposits, showed epidermal and dermal alterations increased with time. It was observed significant increase of epidermal CD1a, TLR2, CCN1 and dermal DC-SIGN, Decorin on Day 2. The injection of test product, associated with bacterial deposits, in contrast to injection of control excipient, associated with bacterial deposits, induced very slight but significant improvement of epidermal viability as well as significant decrease of epidermal TLR2, BD3, CCN1 and dermal DC-SIGN on Day 2.</p><p><strong>Conclusion: </strong>Our investigation showed that both intradermal injections, HA-based solution or control excipient, trigger short-term skin microbiota growth. We indicate strong influence of non-sterile skin surface conditions on human skin explant viability when skin barrier damaged by injection puncture and highlights differences of epidermal/dermal response depended on injected composition.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"459-473"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics Analysis of Oxidative Stress-Related Genes and Immune Infiltration Patterns in Vitiligo.","authors":"Mingmei Yang, Huiying Wang, Ruzhi Zhang","doi":"10.2147/CCID.S496781","DOIUrl":"10.2147/CCID.S496781","url":null,"abstract":"<p><strong>Background: </strong>Vitiligo is an autoimmune disorder characterized by pigment loss, and current treatment options remain inadequate.</p><p><strong>Objective: </strong>This study aims to identify oxidative stress-related biomarkers and hub genes associated with vitiligo diagnosis through genomic analysis and to examine the role of immune cell infiltration in the pathogenesis of vitiligo.</p><p><strong>Methods: </strong>The mRNA expression profile dataset GSE75819 was retrieved from the GEO database. Differential expression of oxidative stress-related genes in vitiligo was analyzed using R software. Protein-protein interaction (PPI) analysis, gene ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted on the differentially expressed genes (DEGs). Immune cell infiltration between vitiligo and normal control groups was assessed using the CIBERSORT algorithm. Additionally, two machine learning algorithms were employed to identify hub genes, perform enrichment analyses, and evaluate their correlation with immune infiltration.</p><p><strong>Results: </strong>A total of 415 Oxidative Stress-DEGs were identified in vitiligo, including 317 up-regulated and 98 down-regulated genes. PPI analysis highlighted the significance of certain ribosomal protein genes. KEGG enrichment analysis suggested an association between vitiligo and various neurodegenerative conditions, particularly through pathways such as oxidative phosphorylation and ribosome biogenesis. GO enrichment analysis indicated that the hub genes were significantly enriched in mitochondrial-related activities. Significant differences in immune infiltration patterns were observed between vitiligo patients and normal controls. Machine learning algorithms identified oxidative stress-related key genes associated with vitiligo, notably the DCT gene, whose expression was strongly linked to the activity of specific immune cell subsets and melanin biosynthetic pathways.</p><p><strong>Conclusion: </strong>Oxidative stress-related DEGs, ribosomal proteins, immune infiltration, and hub genes related to melanin biosynthesis, particularly DCT, are closely associated with the pathogenesis of vitiligo. These findings enhance our understanding of vitiligo and may aid in identifying therapeutic targets for the disease.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"475-489"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comorbidity Pattern in Patients with Moderate-to-Severe Plaque Psoriasis: Network Analysis of a Hospitalized Database in China.","authors":"Wenjuan Chen, Jianfeng Zheng, Xin Wang, Xingzi Li, Yangfeng Ding, Chen Peng, Yuling Shi","doi":"10.2147/CCID.S509739","DOIUrl":"10.2147/CCID.S509739","url":null,"abstract":"<p><strong>Introduction: </strong>Psoriasis is a chronic systemic inflammatory disorder characterized by a high prevalence of comorbid conditions, profoundly affecting patient quality of life and complicating treatment strategies. This study aims to analyze demographic characteristics, prevalence, age distribution, and gender differences of psoriatic comorbidities in hospitalized patients with moderate-to-severe psoriasis at a single center. Additionally, we explore the correlation between comorbidities and psoriasis through network analysis.</p><p><strong>Methods: </strong>A retrospective cross-sectional study was conducted using electronic medical records from the Shanghai Skin Disease Hospital, spanning 2021 to 2023. After removing duplicates, 506 patients diagnosed with plaque psoriasis were included. Comprehensive data on demographics, medical histories, laboratory indices, and comorbid conditions were collected. The Phenotypic Comorbidity Network (PCN) method was employed to examine coexistence patterns of psoriasis with various diseases.</p><p><strong>Results: </strong>79.64% of patients had at least one comorbidity, with Non-alcoholic Fatty Liver Disease (NAFLD), hypertension, hyperlipidemia, overweight/obesity, and hyperuricemia being the top five common comorbidities. The prevalence of these comorbidities increased substantially in the 30-40 and 50-70 age cohorts, notably in hepatic dysfunction and metabolic syndrome. Male patients showed a slightly higher propensity for comorbidities compared to females. Early-onset psoriasis (EOP) patients showed a higher risk for specific conditions than late-onset psoriasis (LOP) patients. PCN analysis identified hepatic dysfunction, hypertension, metabolic syndrome, NAFLD, obesity, hyperlipidemia, and diabetes as strongly associated with psoriasis.</p><p><strong>Conclusion: </strong>This study underscores the systemic nature of psoriasis and its association with diverse comorbidities, emphasizing the necessity of a holistic management approach that addresses both dermatological and comorbid conditions. Identifying key comorbidities guides clinicians in implementing targeted screening and preventive strategies, enhancing patient care and potentially alleviating the overall disease burden.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"491-501"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11878139/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143555961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Generalized Exanthematous Pustulosis in a 76-year-Old Man With Neuroendocrine Carcinoma of the Lung, Responsive to Ixekizumab.","authors":"Jing Zhang, Yue Chen, Duanni Xu, Shaoyin Ma, Yichuan Gan, Yuwu Luo","doi":"10.2147/CCID.S507667","DOIUrl":"https://doi.org/10.2147/CCID.S507667","url":null,"abstract":"<p><p>Acute generalized exanthematous pustulosis (AGEP) is a rare, painful, and pruritic drug-induced rash characterized by sterile pustules on an erythematous base, followed by desquamation. While commonly induced by antibiotics, cases associated with antineoplastic drugs have become more frequent in recent years. Here, we report a 76-year-old Chinese male with lung large-cell neuroendocrine carcinoma who developed erythema and pustules on his left lower leg, which spread to the trunk and limbs after the fourth cycle of immunotherapy and chemotherapy. Despite initial treatments with antihistamines, antibiotics, and systemic glucocorticoids, the patient's condition worsened with the development of extensive pustules and fever. Histopathological and laboratory findings confirmed AGEP, with elevated IL-17 levels. Following the discontinuation of immunotherapy and administration of the anti-IL-17 monoclonal antibody ixekizumab, the patient showed rapid improvement within 5 days, marked by a significant reduction in pustules and normalization of body temperature. This case underscores the role of IL-17 in AGEP's pathogenesis and suggests that IL-17 inhibitors such as ixekizumab may provide an effective treatment option for severe, refractory cases.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"453-458"},"PeriodicalIF":1.9,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11871916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing Causality Between Androgenetic Alopecia with Depression: A Bidirectional Mendelian Randomization Study.","authors":"Haiyang Li, Haibin Cai, Pingwei Li, Yibin Zeng, Yao Zhang","doi":"10.2147/CCID.S501182","DOIUrl":"10.2147/CCID.S501182","url":null,"abstract":"<p><strong>Background: </strong>Androgenetic alopecia (AGA) is the most common form of alopecia globally, which exerts a negative impact on patients' self-esteem and overall quality of life. Previous observational studies have found a significant increase in the prevalence of depression in AGA patients, but the causal relationship remains to be elucidated.</p><p><strong>Methods: </strong>In this study, we conducted a bidirectional Mendelian randomization (MR) using genome-wide association studies (GWAS) datasets. The available GWAS dataset of AGA was obtained from the Neale Lab consortium (n=154988). The dataset for depression was obtained from the ebi-a-GCST90038650 (n=484598). The main analysis method for determining the causal link between AGA and depression was inverse variance weighted (IVW). Subsequently, pleiotropy and heterogeneity tests were performed to determine the reliability of the results.</p><p><strong>Results: </strong>Utilizing the IVW method, depression does not significantly contribute to the incidence of AGA (IVW odds ratio [OR] = 1.101, 95% confidence interval [CI] =0.890-1.362, P = 0.374). Conversely, the data suggested a statistically significant association where AGA may precipitate the development of depression, with a notable increase in risk (IVW OR = 1.015, 95% CI = 1.002-1.029, P = 0.020).</p><p><strong>Conclusion: </strong>We are the first to use MR analysis to explore the causal relationship between AGA and depression, revealing an increased risk of depression in individuals with AGA.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"445-451"},"PeriodicalIF":1.9,"publicationDate":"2025-02-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11863785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143514866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Facial Multiple Melanocytic Nevus-Like Dark Macules Caused by Severe Acne Vulgaris by a Single Session of Intense Pulsed Light Treatment.","authors":"Jinxiang Yang, Jinwen Shen, Yuwei Kong, Lei Wang, Zhirong Yao, Jianying Liang, Xia Yu","doi":"10.2147/CCID.S497696","DOIUrl":"10.2147/CCID.S497696","url":null,"abstract":"<p><strong>Background and objective: </strong>The case report aims to demonstrate the therapeutic effects of a single session of intense pulsed light (IPL) treatment on facial multiple melanocytic nevus-like dark macules induced by severe acne vulgaris.</p><p><strong>Materials and methods: </strong>A 17-year-old male with acne was assessed as Pillsbury IV according to the Pillsbury classification. After three sessions of photodynamic therapy (PDT), he experienced an increase in number and darkening of facial melanocytic nevus-like dark macules. We attempted to use broadband light (BBL) (SCITON Company, USA) (420nm, 8J, 180ms; 515nm, 13J, 20ms; 560nm, 16J, 24ms; 590nm, 16J, 24ms) therapy to improve post-inflammatory erythema (PIE) and post-inflammatory hyperpigmentation (PIH). Following a baseline assessment, we performed a single session of IPL treatment on the patient and evaluated the changes in melanocytic nevus-like dark macules, PIE, PIH, and sebum secretion through standardized photography.</p><p><strong>Results: </strong>Compared to the baseline, we observed a significant reduction of the patient's melanocytic nevus-like dark macules and a significant improvement in PIE, PIH, and sebum secretion after a single IPL treatment.</p><p><strong>Conclusions: </strong>This study provides preliminary evidence of the effects of IPL treatment on melanocytic nevi associated with severe acne vulgaris. Further research is warranted to elucidate the underlying mechanisms and promote the wider application of this treatment modality in managing acne sequelae.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"427-430"},"PeriodicalIF":1.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853118/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Koebner Phenomenon Is an Indicator of Vitiligo Activity and Aggression [Letter].","authors":"Yingjian Tan, Yue Zeng, Rui Li","doi":"10.2147/CCID.S522969","DOIUrl":"10.2147/CCID.S522969","url":null,"abstract":"","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"443-444"},"PeriodicalIF":1.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853826/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevention and Management of Complications With a Hyaluronic Acid-Calcium Hydroxyapatite Hybrid Injectable.","authors":"Wolfgang G Philipp-Dormston, Koenraad De Boulle, David B Eccleston, Rachna Murthy, Karim Sayed, Philippe Snozzi, Fernando Urdiales-Galvez","doi":"10.2147/CCID.S506038","DOIUrl":"10.2147/CCID.S506038","url":null,"abstract":"<p><strong>Background: </strong>A ready-to-use hyaluronic acid-calcium hydroxyapatite (HA-CaHA) hybrid injectable has a dual mode of action for soft-tissue augmentation. Although previous studies have reported a favorable safety profile for HA-CaHA, there is a need for guidelines and recommendations based on real-world clinical experience for the management of complications associated with HA-CaHA.</p><p><strong>Purpose: </strong>This publication provides guidelines and recommendations for the prevention and management of HA-CaHA-related complications. A case study example, treatment algorithms, and injection techniques are included to illustrate the management of complications.</p><p><strong>Materials and methods: </strong>On January 25, 2023, 13 European physicians were invited to an advisory board meeting to discuss strategies for optimizing patient care, minimizing adverse events (AEs), and identifying data gaps for the prevention and management of complications with HA-CaHA.</p><p><strong>Results: </strong>The management of a subset of AEs, including skin discoloration and edema, was discussed. Small group workshops also shared management algorithms for late noninflammatory adverse reactions, late inflammatory adverse reactions, localized vascular complications, and retinal vascular complications. Best practices for optimal injection techniques were discussed, and injection-technique protocols were developed for treatment sites. Treatment strategies for HA-CaHA-related complications are considered similar to treatment of those resulting from single-agent fillers, and knowledge of anatomy, aseptic technique, correct injection techniques, and appropriate posttreatment care is emphasized.</p><p><strong>Conclusion: </strong>These recommendations on the management of HA-CaHA-related complications may serve as a reference for the broad range of clinicians using HA-CaHA hybrid injectable for different indications and can help optimize patient outcomes and safety.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"431-441"},"PeriodicalIF":1.9,"publicationDate":"2025-02-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11853979/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499669","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comment on \"Trends and Associations of Chilblains Prevalence with Connective Tissue Diseases, Including COVID-19 Incidence\" [Letter].","authors":"Yingjian Tan, Rui Li","doi":"10.2147/CCID.S521256","DOIUrl":"10.2147/CCID.S521256","url":null,"abstract":"","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"417-418"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846528/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}