Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Micro-Focused Ultrasound on an Individual with Titanium Facial Implants: A Case Report.","authors":"Dissapong Panithaporn","doi":"10.2147/CCID.S533425","DOIUrl":"10.2147/CCID.S533425","url":null,"abstract":"<p><strong>Introduction: </strong>Both micro-focused ultrasound (MFU) and monopolar radiofrequency (MRF) interventions are relatively safe and well tolerated as a non-invasive approach to achieve rejuvenating effects, with patients reporting limited adverse effects. However, MRF uses an electrical current which can induce heating in metal, potentially causing burns or thermal injury in the skin or tissue around the implant, whereas MFU delivers focused high-energy ultrasound, which does not induce electrical currents in metal.</p><p><strong>Case presentation: </strong>This report describes the case of a 28-year-old Thai male, who received titanium implants in the mandible bone, the mandible chin, the maxillary bone and the zygoma bone, seven years before. Because of his wish for a more sculpted and lifted facial appearance, the patient was treated with Ulthera Legacy in 2021 and with Ulthera Prime in 2024. With Ulthera Prime, visualization has significantly improved, which decreased the need to skip areas, leading to improved, more consistent results.</p><p><strong>Conclusion: </strong>This case study suggests that Ulthera Prime could be an option for skin firming and lifting effects for people with facial implants. Further research will be needed to corroborate this finding in a larger population.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1769-1773"},"PeriodicalIF":2.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Cutaneous Horn on a Lower Extremity with Granuloma Annulare: A Rare Co-Occurrence.","authors":"Xiaolin Bu, Liwei Feng, Jing Guo, Rongzhu Yu, Xinling Bi","doi":"10.2147/CCID.S520386","DOIUrl":"10.2147/CCID.S520386","url":null,"abstract":"<p><p>A 65-year-old Asian male presented with a circular skin lesion on the flexor aspect of the right calf that first appeared at age 13 and gradually expanded peripherally. Six months prior to presentation, a dark brown, horn-like keratotic lesion with a hard texture emerged on the annular lesion, growing progressively without pain or pruritus. The cutaneous horn was surgically excised, and the annular lesion underwent biopsy. Pathological findings revealed abundant mucin in dermal collagen, dense histiocyte infiltration, and focal mild collagen degeneration, confirming a diagnosis of granuloma annulare complicated by a cutaneous horn.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1753-1756"},"PeriodicalIF":2.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyaluronic Acid Combined with Diluted and Hyperdiluted Calcium Hydroxylapatite to Treat the Periocular Area.","authors":"Julieta Spada, Jani Van Loghem","doi":"10.2147/CCID.S518475","DOIUrl":"10.2147/CCID.S518475","url":null,"abstract":"<p><strong>Purpose: </strong>A combination of fillers and other modalities is often required to address all signs of periorbital aging. Patients are injected for volume loss, and for hyperpigmentation are treated with a combination treatments with chemical peels and lasers, but multiple visits can be burdensome. To streamline the current treatment approach for the periocular area, the current study investigated the benefit of the treatment with a blend of Hyaluronic Acid (HA) and Calcium Hydroxylapatite (CaHA). This dual-filler strategy is designed to utilize the rheological and volume replacement capabilities of HA alongside the bioregenerative effects of CaHA while avoiding excessive edema and/or delayed swelling that may occur when HA is injected alone.</p><p><strong>Methods: </strong>One hundred and six adults were treated with a blend of crosslinked HA (22.5 mg/mL) and diluted/hyperdiluted CaHA. The filler ratio was chosen based on individual skin thickness and depth of palpebro-malar groove (PG) or supraorbital hollowness (SH). Assessments were performed at baseline (T0), 30, 60, 90, and 365 days. One patient underwent a comparative analysis of HA alone versus the HA-CaHA blend, evaluated through ultrasound, Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) scan post-injection.</p><p><strong>Results: </strong>All treated patients presented natural-looking results, less pronounced PG and SH with minimal edema on D30, and skin quality improvement with less laxity, wrinkling and pigmentation. No hyaluronidase injections for overcorrections were required. No severe complications were observed. For most patients, results varied according to the dilution of the blend; lower dilutions (1:1) lasted longer than higher dilution (1:4), even though results were still noticeable for patients treated with the latter (1:4) at the 1-year evaluation.</p><p><strong>Conclusion: </strong>This study validates the use of a HA and CaHA blend (CaHA-CPM) for periocular rejuvenation, addressing various aging symptoms in this complex facial region.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1741-1752"},"PeriodicalIF":1.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Secondary Syphilis on Infant.","authors":"Zhe Cao, Zhen Hua Wang, Ai Juan Sun","doi":"10.2147/CCID.S515183","DOIUrl":"10.2147/CCID.S515183","url":null,"abstract":"<p><p>Secondary syphilis, a stage of sexually transmitted infection caused by Treponema pallidum, typically presents with a range of symptoms in adults. However, when this condition affects an infant, it becomes a rare and serious medical concern. This article explores a unique case of secondary syphilis in an infant, highlighting the diagnostic challenges, treatment options, and the importance of early intervention.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1737-1739"},"PeriodicalIF":1.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Link of Distinct Mental Disorders with Androgenetic Alopecia and Alopecia Areata: A Bidirectional Two-Sample Mendelian Randomization Study.","authors":"Chunyu Hu, Zhen Cheng, Yuanling Tao, Laixi Zhang, Yalan Zhang, Zongtao Chen","doi":"10.2147/CCID.S531734","DOIUrl":"10.2147/CCID.S531734","url":null,"abstract":"<p><strong>Background: </strong>The concern that mental states affect the hair-loss has been growing, but the causal evidence is still limited. We aimed to investigate whether and in which direction there is a causal link of distinct mental disorders with androgenetic alopecia (AGA) and alopecia areata (AA) in European population.</p><p><strong>Methods: </strong>We performed a bidirectional two-sample Mendelian randomization (MR) study to test their causality using summary statistics. The datasets of major depression disorder, anxiety disorder, panic attack, distress, and bipolar disorder were all accessed through the IEU OpenGWAS project. The datasets employed for AGA and AA analysis were sourced from the FinnGen release 10 databases, including 219,469 (220 AGA cases and 219,249 controls) and 394,872 (767 AA cases and 394,105 controls) participants, respectively. We utilized five extensively employed MR techniques to explore the bidirectional causal associations, including inverse variance weighted (IVW), weighted median, MR-Egger, weighted mode, and penalised weighted median.</p><p><strong>Results: </strong>Based on the IVW method, a bidirectional causal association was revealed whereby major depression disorder is associated with an increased risk of AA (OR: 1.59; 95% CI: 1.16-2.17) and vice versa (OR: 1.02; 95% CI: 1.00-1.03). Notably, the statistical power of MR estimates was both <80%. No association of any genetically predicted mental disorders with AGA was found. Sensitivity analyses substantiated the robustness and reliability of our findings.</p><p><strong>Conclusion: </strong>Our findings showed a bidirectional causal association between major depression disorder and AA, supporting the importance of therapies aimed at handling mental states for the prevention or treatment of AA rather than AGA.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1727-1736"},"PeriodicalIF":1.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms and Therapeutic Roles of Medicinal Plants in Skin Photoaging.","authors":"Xinxin Lei","doi":"10.2147/CCID.S538326","DOIUrl":"10.2147/CCID.S538326","url":null,"abstract":"<p><p>Photoaging refers to the cumulative skin damage primarily caused by exposure to ultraviolet (UV) radiation. This process results in the harmful effects of UV irradiation on skin cells, leading to alterations in the extracellular matrix, which consequently impacts the appearance and function of the skin. This review aims to elucidate how bioactive compounds from medicinal plants counteract UV-induced damage, as identified by current mechanistic and molecular studies. Over the past few decades, medicinal plants have garnered increasing attention for their potential therapeutic benefits in treating various human diseases. Numerous studies have explored the anti-photoaging properties of herbal remedies, revealing that various active compounds, extracts, and combinations of medicinal plants can mitigate photoaging in different skin cells through diverse signaling pathways. Compared to synthetic agents, herbal remedies offer lower toxicity profiles and are often perceived as safer alternatives, making them attractive options for long-term skin care and photoaging prevention. These findings suggest that herbal plants can reduce UV-induced skin damage primarily by inhibiting the production of reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and inflammatory mediators, while simultaneously promoting collagen synthesis. The underlying mechanisms of these effects are associated with key cellular pathways, including MAPK, NF-κB, Nrf2, and TGF-β/Smad. These findings suggest that herbal plants can reduce UV-induced skin damage by inhibiting reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and inflammatory mediators, while promoting collagen synthesis. This review provides novel insight into cell-specific mechanisms by which medicinal plants mitigate photoaging, laying the groundwork for their potential therapeutic application.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1709-1726"},"PeriodicalIF":1.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Exosomes From Hypoxia-Induced Adipose-Derived Stem Cells on Ameliorating Photoaging.","authors":"Cuc Bach Huynh, Ngoc Bich Vu, Trung The Van, Phuc Van Pham","doi":"10.2147/CCID.S523936","DOIUrl":"10.2147/CCID.S523936","url":null,"abstract":"<p><strong>Introduction: </strong>Photoaging, a significant concern in cosmetic dermatology, involves complex skin damage that necessitates effective treatments. Exosomes derived from adipose-derived stem cells (ADSCs), particularly those generated under hypoxic conditions (hypADSC-Exo), have emerged as a promising cell-free therapeutic approach. This study investigates the effects of hypADSC-Exo on reducing human dermal fibroblast (HDF) senescence and mitigating signs of photoaging through topical application in a mouse model.</p><p><strong>Methods: </strong>Exosomes were isolated from hypoxia-induced human ADSCs via ultracentrifugation and identified using flow cytometry (CD9, CD63, CD81). Transmission electron microscopy (TEM) confirmed the vesicle morphology, while the Bradford assay and nanoparticle tracking analysis (NTA) assessed the protein content and size. In vitro, UV-induced senescent HDFs were treated with hypADSC-Exo. Cell morphology, senescence (SA-β-gal assay), proliferation (Alamar Blue), and gene expression (p16, p21 via qPCR) were evaluated. In vivo, photoaged mice received hypADSC-Exo treatments (50 or 100 μg/mL) twice weekly for six weeks. Skin parameters (wrinkles, thickness, hydration, elasticity) were evaluated biweekly. Skin biopsies were used to assess epidermal and dermal thickness, collagen density, and gene expression of collagen types 1, 3 and MMP-1, 2, and 3.</p><p><strong>Results: </strong>hypADSC-Exo exhibited a cup-shaped morphology under TEM and expressed exosomal markers CD9, CD63, and CD81. In vitro, hypADSC-Exo improved HDF morphology, reduced SA-β-gal activity, enhanced proliferation, and downregulated p16 and p21. In vivo, it reduced skin wrinkles and thickness. Treated mice exhibited improvement in hydration, elasticity, decreased epidermal and dermal thickness, and increased collagen density. Collagen types 1 and 3 increased slightly, while the levels of MMP-1, 2, and 3 decreased in the exosome group.</p><p><strong>Conclusion: </strong>Our findings demonstrate that hypADSC-Exo reduces senescence in UV-induced aged HDF and improves photoaging in mice. These effects likely result from decreased MMP-1, 2, 3 expression and increased collagen deposition, making hypADSC-Exo a promising therapy for photoaging.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1683-1702"},"PeriodicalIF":1.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Basal Cell Carcinoma Arising Within a Favre-Racouchot Syndrome Lesion: A Rare Case and Literature Review.","authors":"Hui Li, Shuhua Li, Tiantian Dong, Jun Liu, Yi Sun","doi":"10.2147/CCID.S531359","DOIUrl":"10.2147/CCID.S531359","url":null,"abstract":"<p><p>Concurrence of Favre-Racouchot syndrome (FRS), a chronic dermatosis, and skin cancer is rare. In this study, we present an exceptionally rare case of basal cell carcinoma (BCC) arising within a FRS lesion. An 84-year-old female farmer had a mass in the lower left limb for 30 years without medical treatment. Over the past year, especially in the month prior to this visit, the mass enlarged significantly. On examination, a well-defined, rounded mass measuring approximately 4 cm in diameter was noted on the anterior aspect of the left calf. The mass had a rough surface with papillary hyperplasia and a mild erythema at the base. Open and closed comedones were observed, but no cysts or yellowish nodules were present. Histopathological analysis showed degradation and reduction of elastic fibers in the lesion dermis, along with the presence of comedones and cysts. Furthermore, scattered basaloid cell nests of varying sizes were present in the dermis, with peripheral tumor cells arranged in a palisading pattern. Peritumoral clefts were observed and the cell nuclei were hyperchromatic and occupied most of the cell. BCC associated with FRS was diagnosed. The patient underwent complete surgical excision. No recurrence was observed over an 18-month follow-up period. In conclusion, concurrence of BCC and FRS is rare. Delayed diagnosis of this condition can lead to more invasive disease progression. To improve early detection for timely treatment, clinicians should maintain a high index of suspicion for malignant transformation in patients with longstanding FRS, particularly those presenting with rapidly evolving lesions.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1703-1708"},"PeriodicalIF":1.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12256777/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Deucravacitinib Improved Interstitial Pneumonia Along with KL-6 Reduction in a Patient with Psoriasis: A Case Report.","authors":"Yoshihito Mima, Tsutomu Ohtsuka, Norimichi Akiyama, Yuta Norimatsu","doi":"10.2147/CCID.S536534","DOIUrl":"10.2147/CCID.S536534","url":null,"abstract":"<p><p>This case report describes a patient with psoriasis and interstitial pneumonia (IP) presenting with linear opacities who was treated with deucravacitinib, aiming to highlight the potential role of deucravacitinib in improving IP. Psoriasis is a chronic immune-mediated skin disease involving T helper (Th) 17 cells, often accompanied by systemic comorbidities. Deucravacitinib, a selective oral tyrosine kinase 2 (TYK2) inhibitor targeting interleukin (IL)-23 and type I interferons, has shown strong efficacy and safety in psoriasis treatment. Interstitial pneumonia (IP) is a group of lung diseases characterized by inflammation, fibrosis, and progressive respiratory decline. Cytokines play key roles in its pathogenesis. Emerging evidence suggests that psoriasis has higher risks of IP, possibly due to shared IL-23/IL-17 pathway. The patient showed marked improvement in skin and lung findings, along with KL-6 levels after deucravacitinib treatment. TYK2 mediates downstream signaling of key pro-fibrotic and pro-inflammatory cytokines involved in IP. Therefore, we consider that deucravacitinib may have contributed to the improvement of IP by blocking these signaling pathways, thereby suppressing chronic T cell-driven inflammation and fibrosis. Further accumulation of cases and continued research will be essential in advancing discussions on the clinical utility of TYK2 inhibitors in IP management.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1677-1681"},"PeriodicalIF":1.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255260/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the Impact of Circulating Immune Cells on Acne Using Mendelian Randomization.","authors":"Xudong Wang, Shaoyu Guan, Zhikuan Xia, Xin Zhang, Yu Bai, Qiang Li, Haitao Li, Rongya Yang","doi":"10.2147/CCID.S525621","DOIUrl":"10.2147/CCID.S525621","url":null,"abstract":"<p><strong>Background: </strong>While growing evidence suggests the intricate relationship between immune cells and the pathogenesis of acne, the causative implications underlying these associations remain poorly characterized. This study aimed to elucidate the causal links between various immune cell phenotypes and the development of acne using Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>Leveraging data of 731 immune cell traits and acne from genome-wide association studies, we conducted a bidirectional MR analysis. Rigorous instrumental variables selection was followed by causal inference using five complementary methods, including MR-Egger, weighted median, simple mode, inverse variance weighted (IVW), and weighted mode methods. Heterogeneity and pleiotropy were evaluated using Cochran's Q test, MR-Egger intercept test, and leave-one-out analysis.</p><p><strong>Results: </strong>Genetically predicted alterations in 26 immune cell phenotypes demonstrated causal associations with acne risk. Notably, 18 immune cell types exhibited protective effects, such as CD25 on IgD+ (IVW: OR 0.922, 95% CI 0.868-0.979; <i>p</i> = 0.008), naive-mature B cell %lymphocytes (IVW: OR 0.824, 95% CI 0.698-0.972; <i>p</i> = 0.022), and CD19 on sw mem (IVW: OR 0.841, 95% CI 0.752-0.940; <i>p</i> = 0.002). Conversely, 8 immune cell types conferred increased risk, such as IgD+ CD38dim AC (IVW: OR 1.054, 95% CI 1.002-1.108; <i>p</i> = 0.043), CD25 on unsw mem (IVW: OR 1.058, 95% CI 1.005-1.114; <i>p</i> = 0.030), and CD28+ DN (CD4-CD8-) %DN (IVW: OR 1.117, 95% CI 1.019-1.225; <i>p</i> = 0.019). The absence of significant heterogeneity or horizontal pleiotropy (<i>p</i> > 0.05) strengthens the credibility to the observed associations.</p><p><strong>Conclusion: </strong>In conclusion, this research provides compelling genetic evidence for causal immunomodulatory influences on acne development, thus laying the groundwork for future investigational efforts aimed at uncovering targeted therapeutic strategies in acne management.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1665-1675"},"PeriodicalIF":1.9,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255251/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144625418","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}