Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Meyerson's Phenomenon Induced by Molluscum Contagiosum in an Adult: A Rare Case Report.","authors":"Daxing Wu, Jianzhong Xu, Lifeng Wu","doi":"10.2147/CCID.S537026","DOIUrl":"10.2147/CCID.S537026","url":null,"abstract":"<p><p>The Meyerson's phenomenon is an uncommon reactive process that can be triggered by various cutaneous lesions, including melanocytic nevi, capillary malformations, seborrheic keratoses, dermatofibromas, sebaceous nevi, and scars, among others. Here, we report a rare case of Meyerson's phenomenon induced by molluscum contagiosum in an adult, along with its dermoscopic features and treatment response.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1845-1848"},"PeriodicalIF":2.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323876/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Palmoplantar Keratodermas Complicated by Pseudoainhum and Literature Review.","authors":"Junhong Ye, Wen Li, Xianxu Yang, Yanhai Shi, Wen Lv","doi":"10.2147/CCID.S534631","DOIUrl":"10.2147/CCID.S534631","url":null,"abstract":"<p><p>A 43-year-old man who had presented diffuse plaques on both hands and feet for 10 years and constriction of the fifth digit of the right foot for 1 year was included in this case report. Diffuse hyperplastic yellow-brown plaques were observed in the palms of both hands and soles of both feet in this man. Yellowish crusting formed on the plaques. There was much white debris on the surface lesions. The fifth phalanx of the right foot was ring-shaped and narrowed, and the toe was globular. Color Doppler ultrasound examination revealed arteriosclerosis and multiple small plaques in the right lower limb vessel. An antero-posterior radiograph of the right foot showed constriction of the fifth phalanx. The man was diagnosed with palmoplantar keratodermas complicated by pseudoainhum.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1827-1831"},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case-Control Study Exploring the Association Between Cosmetic Use and Acne Risk: Implications for Prevention and Clinical Practice.","authors":"Kitman Choi, Hsingmei Liu, Yingying Zhu, Zhuoyu Jiang, Sha Lu","doi":"10.2147/CCID.S533950","DOIUrl":"10.2147/CCID.S533950","url":null,"abstract":"<p><strong>Background: </strong>Acne cosmetica refers to acne breakouts caused by cosmetics. Various factors within cosmetics can contribute to the occurrence of acne cosmetica. However, there is a lack of epidemiological surveys on the risk of acne caused by comedogenicity ingredients in cosmetics. This research seeks to examine the correlation between the cosmetics usage and the incidence of acne by focusing on three key factors: the kind of cosmetic exposure, the cosmetic exposure index, and the usage of cosmetic containing comedogenicity ingredients.</p><p><strong>Methods: </strong>We collected information from 151 participants in the case-control study who answered a self-administered questionnaire about cosmetics assessment. Participants were evaluated based on their cosmetic usage and exposure.</p><p><strong>Results: </strong>Our findings indicated that facial cleansers (<i>P</i>=0.04), foundation (<i>P=</i>0.03), and powders (<i>P=</i>0.01) were related with an increased risk of acne, with the impact ranking from greatest to least as facial cleansers > powders > foundation. When adjusting for variables such as age, occupation, parental history of acne, and the milk consumption, only the usage of powders remained a significant risk factor for acne [OR (95% CI): 3.47 (1.58-7.59), <i>P=</i>0.02]. Additionally, moisturizers were identified as independent risk factors for acne, with a higher usage dose correlating with an increased risk [OR (95% CI): 1.03 (1.01-1.05), <i>P=</i>0.03]. Furthermore, facial cleansers containing comedogenic ingredients were also discovered to be an independent risk factor for acne [OR (95% CI): 2.49 (1.23-4.90), <i>P=</i>0.01].</p><p><strong>Conclusion: </strong>Certain cosmetic products may elevate the risk of developing acne, with risk levels influenced by both the dosage of the products and their specific ingredients.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1833-1843"},"PeriodicalIF":2.2,"publicationDate":"2025-07-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12323874/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144788423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Immune Cells and Circulating Inflammatory Cytokines on Pathological Scars: A Mendelian Randomization Study.","authors":"Yang Xu, Weisheng Zhan, Juhua Zhao","doi":"10.2147/CCID.S532061","DOIUrl":"10.2147/CCID.S532061","url":null,"abstract":"<p><strong>Background: </strong>Pathological scars are the products of abnormal repair during the wound healing process. Previous researches have demonstrated that immune cells and inflammatory cytokines are closely associated with pathological scars. However, the causality between immune cells, inflammatory cytokines and pathological scars remains unclear.</p><p><strong>Methods: </strong>After obtaining genome-wide association studies (GWAS) data on immune cells, cytokines, hypertrophic scars, and keloids, we selected appropriate single - nucleotide polymorphisms (SNPs) for Mendelian randomization (MR) analysis. The inverse-variance weighted (IVW) method was used as the main analytical method. Sensitivity analyses were conducted to evaluate reliability of research findings.</p><p><strong>Results: </strong>Our research results indicated that 10 immunophenotypes can increase risk of hypertrophic scars, 5 immunophenotypes can decrease risk of hypertrophic scars, 3 inflammatory cytokines can increase risk of hypertrophic scars, and 2 inflammatory cytokines can decrease risk of hypertrophic scars. Meanwhile, 5 immunophenotypes can increase risk of keloids, 4 immunophenotypes can decrease risk of keloids, 1 inflammatory cytokine can increase risk of keloids, and 1 inflammatory cytokine can decrease risk of keloids.</p><p><strong>Conclusion: </strong>This study reveals the roles of immune phenotypes and cytokines in the pathogenesis of pathological scars, and provides valuable references in research areas such as early identification and intervention treatment of pathological scars.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1817-1826"},"PeriodicalIF":2.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317736/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Narrow-Margin Treatment with Modified Mohs Microsurgery for Extramammary Paget's Disease: A Retrospective Clinical Analysis.","authors":"Jing Yang, Jianna Yan, Hao Luo, Liang Li, Long Jiang, Xuewen Chen, Ling Wu, Jingxiu Chai, Huan Xue, Leimeng Gan, Yeqiang Liu, Jia Chen, Wu Fei, Yun Bai, Quangang Zhu, Zhongjian Chen, Lehang Guo, Yuchong Chen","doi":"10.2147/CCID.S516022","DOIUrl":"10.2147/CCID.S516022","url":null,"abstract":"<p><strong>Background: </strong>To investigate the clinical efficacy of narrow-margin modified Mohs microsurgery (mMMS) in the treatment of extramammary Paget's disease (EMPD).</p><p><strong>Methods: </strong>A retrospective cohort review was conducted on 52 patients with EMPD who were treated at the Skin Disease Hospital of Tongji University in Shanghai between 2017 and 2023. The primary objectives of this study were to assess the long-term local recurrence rates of tumors treated with narrow-margin mMMS and to explore the final margin width as well as the factors that may influence postoperative recurrence.</p><p><strong>Results: </strong>A total of 52 patients were included in this retrospective study. Most patients were male (n = 48, 92.3%) with a mean age of 69.5 years (SD:9.08, range:44-91). The follow-up rate was 78.7% (41/52), and the mean follow-up time was 36.17 months (SD:18.25, range 5.8-62.5). The recurrence rate was 9.7% (4/41) and the 5-year tumor-free rate was 85.9%. Approximate 95% of tumors with 1 cm of non-scrotal skin extension or 1.5 cm of scrotal skin extension could be completely cleared. Univariable analysis revealed that hypopigmented patches (HR=14.0, 95% CI=1.269,154.395, p = 0.031) correlated with tumors recurrence.</p><p><strong>Conclusion: </strong>Narrow-margin mMMS is the ideal therapy combine a disease control rate with more satisfying functional results. Determination of tumor boundaries requires attention to skin lesions with hypopigmented macules. The initial resection margins width of the extension cut can be reduced in non-scrotal skin lesions at the time of surgery to minimize pointless margin expansion.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1791-1799"},"PeriodicalIF":2.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317710/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774811","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High-Intensity Focused Ultrasound (HIFU) Treatment of Vulvar Lichen Sclerosus.","authors":"Jacek Calik, Bartosz Woźniak, Marek Murawski, Piotr Donizy, Natalia Sauer","doi":"10.2147/CCID.S525384","DOIUrl":"10.2147/CCID.S525384","url":null,"abstract":"<p><p>Vulvar lichen sclerosus (VLS) is a chronic, recurrent dermatosis predominantly affecting postmenopausal women. It is characterized by atrophic and sclerotic changes in the vulvar skin, often causing severe discomfort and functional impairment. Although potent topical corticosteroids remain the primary treatment, high-intensity focused ultrasound (HIFU) emerges as a promising alternative in recurrence cases. This study reports the case of a 73-year-old woman with VLS treated using HIFU, aiming to assess the safety and efficacy of this novel therapeutic approach. The patient presented with significant discomfort due to VLS and had a history of limited response to previous treatments. HIFU therapy was applied using the System ONE-M device operating at 20 MHz, targeting specific lesions. The dermoscopic evaluation was performed pre- and post-treatment to assess the treatment response. Immediate post-procedural whitening of tissues was observed, followed by gradual healing over five months. The patient experienced significant symptom relief, including reduced pain and itching, with minimal adverse effects. The treated areas displayed nearly normal skin color, texture, and improved function within five months post-treatment. This case illustrates the potential of HIFU as an effective and precise non-invasive treatment for VLS, offering significant symptom relief while sparing healthy tissue. Further research is needed to refine treatment parameters and explore the broader clinical applicability of HIFU for VLS management.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1809-1815"},"PeriodicalIF":2.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12317702/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774809","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Features, Diagnostic Challenges, and Therapeutic Outcomes of 105 Pilomatricoma Cases.","authors":"Changpei Lu, Rongshuang Zhang, Lingbo Bi, Ting Luo, Wenbing Lai, Weixin Fan, Haixia Jing","doi":"10.2147/CCID.S518408","DOIUrl":"10.2147/CCID.S518408","url":null,"abstract":"<p><strong>Purpose: </strong>To conduct a retrospective review and analysis of clinical data on pilomatricoma over the past 9 years, with a focus on clinical characteristics, Diagnostic Challenges, and Therapeutic Outcomes.</p><p><strong>Patients and methods: </strong>We performed a retrospective study on patients diagnosed with pilomatricoma at our department from 2013 to 2022. Data collected from hospital and outpatient records, as well as pathological reports, included patient age, sex, onset, clinical and histopathological features, preoperative diagnosis, treatment methods, recurrence, and outcomes.</p><p><strong>Results: </strong>A total of 105 patients were included. The primary clinical manifestation was a slowly growing subcutaneous mass. The median age at excision was 14 years, with the youngest patient being 8 months old and the oldest 71 years old. Head and neck tumors accounted for 67.6% (n=71) of cases, followed by the upper limbs (20.9%, n=22), with other sites including the back and lower limbs. The male-to-female ratio was 1:1.6. Tumor diameter ranged from 0.4 to 5.0 cm, with a mean of 1.0 cm. Only one case exhibited recurrence. Differential diagnoses included epidermoid cyst, sebaceous cyst, and fibroma, among others. The characteristic histopathological features were eosinophilic ghost cells and basophilic basal-like cells arranged in irregular strands or clusters. The preoperative diagnosis was consistent with the pathological diagnosis in only 28 cases (26.7%). The optimal treatment approach is complete surgical excision, with a low recurrence rate of 1.0%. No cases of malignant transformation were observed.</p><p><strong>Conclusion: </strong>Pilomatricoma is a benign tumor with atypical morphology, often leading to misdiagnosis. Careful histopathological examination is crucial, and early excision demonstrates significant effectiveness in preventing recurrence.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1801-1807"},"PeriodicalIF":2.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12316045/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144774808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab as Immunomodulatory Rescue for Severe Recalcitrant Pemphigus Vulgaris: A Case Report and Literature Review.","authors":"Suphagan Boonpethkaew, Kumutnart Chanprapaph","doi":"10.2147/CCID.S535496","DOIUrl":"10.2147/CCID.S535496","url":null,"abstract":"<p><p>Standard treatment of pemphigus vulgaris (PV) includes corticosteroid, immunosuppressants, and biologics such as rituximab, a monoclonal antibody targeting CD20⁺ B cells. However, some patients develop resistance to rituximab, requiring alternative therapeutic approaches. We report a 15-year-old female with severe PV who developed rituximab refractoriness after an initially effective response. Despite treatment with a combination of intravenous immunoglobulin, corticosteroid, and immunosuppressants, the patient failed to achieve disease control. Consequently, dupilumab, an interleukin-4 receptor α antagonist, was initiated on a biweekly regimen. Her lesions showed dramatic improvement, with the pemphigus disease area index (PDAI) reaching 0. Her anti-desmoglein 1 antibody level became negative, and T helper (Th)-2 inflammatory markers, including eosinophil count and immunoglobulin E (IgE) level, was normalized, allowing corticosteroid tapering after the 8th dose (last dose) of dupilumab. She has maintained complete remission for at least 28 weeks with regular follow-ups. We additionally propose possible mechanisms underlying rituximab refractoriness and how dupilumab modulates this treatment response. Our case highlights dupilumab's potential in modulating Th-2-driven autoantibody production for PV patients with high peripheral eosinophils and IgE levels who have severe disease resistant to corticosteroids or rituximab.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1775-1782"},"PeriodicalIF":2.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Photodynamic Therapy, 2% Salicylic Acid, and Their Combination for Moderate Acne.","authors":"Liping Li, Yan Huang, Jindong Lai, Xinyu Lin","doi":"10.2147/CCID.S532029","DOIUrl":"10.2147/CCID.S532029","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the effectiveness of photodynamic therapy combined with 2% salicylic acid for treating moderate acne.</p><p><strong>Methods: </strong>This retrospective study included outpatients with moderate acne who consulted the Department of Dermatology at Suining First People's Hospital in Sichuan Province between April 2019 and December 2019. The patients were grouped into the photodynamic group, the salicylic acid group, and the combination therapy group, according to whether they received aminolevulinic acid photodynamic therapy, a 2% supramolecular salicylic acid topical masque applied once daily for 10 minutes and then washed off for four consecutive weeks, 2% salicylic acid therapy, or both treatments combined. The overall effective rate was calculated as the percentage of patients with a 60% or greater reduction in skin lesions. Adverse reactions were also collected.</p><p><strong>Results: </strong>A total of 66 patients were included, with 22 patients in each group. The combination therapy group had an overall effective rate of 72.73%, which was higher compared to the photodynamic group at 40.91% and the salicylic acid group at 22.73% (5 cases, <i>P</i> < 0.003). The skin lesions decreased in the photodynamic group, salicylic acid group, and combination therapy group by 11.72±4.80%, 8.62±3.16%, and 15.12±7.61% (<i>P</i>=0.01) at week one; 26.26±5.52%, 24.19±5.88%, and 33.11±8.90% (<i>P</i>=0.01) at week two; 42.63±7.25%, 39.21±9.91%, and 47.31±9.15% (<i>P</i>=0.01) at week three; and 58.84±9.45%, 52.35±8.75%, and 65.97±7.20% (<i>P</i>=0.01) at week four. Some patients experienced mild discomfort (redness, itching, pain), but no severe adverse reactions were reported.</p><p><strong>Conclusion: </strong>Photodynamic therapy combined with 2% salicylic acid therapy reduced the number of skin lesions in patients with moderate acne more than either treatment alone. The combination therapy may be tolerable with no severe adverse reactions.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1783-1790"},"PeriodicalIF":2.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celiac Disease and Skin Diseases: A Bidirectional Mendelian Randomization Study.","authors":"Chenyang Ge, Yizheng Wang, Xuegang Zhao, Jiawen Hao, Jing Zhang, Mengyuan Lu, Congying Li, Jianke Feng, Qingfu Zhang","doi":"10.2147/CCID.S533378","DOIUrl":"10.2147/CCID.S533378","url":null,"abstract":"<p><strong>Background: </strong>Research as shown that celiac disease (CD) is associated with skin diseases, but their causality remains unclear. Therefore, this Mendelian randomization (MR) study evaluated the causality between CD and skin diseases.</p><p><strong>Methods: </strong>Bidirectional MR analysis was performed on single nucleotide polymorphism (SNP) candidates identified from genome-wide association study (GWAS) datasets using inverse variance weighted (IVW), weighted median, MR-egger, weighted mode and simple mode. Multivariate MR (MVMR) analysis was subsequently conducted by adjusting for BMI, smoking, and alcohol use. Result reliability was assessed by horizontal pleiotropy and heterogeneity testing.</p><p><strong>Results: </strong>IVW analysis revealed that CD increased the risk of atopic dermatitis (OR = 1.042, 95% CI: 1.018-1.067, <i>P</i> = 5.75 × 10^-4) and cellulitis (OR = 1.026, 95% CI: 1.006-1.046, <i>P</i> = 9.18×10^-3). Additionally, psoriasis had a suggestive association with CD (OR=0.836, 95% CI: 0.710-0.983, <i>P</i> = 0.031). MVMR analysis demonstrated that CD had a direct effect on atopic dermatitis and cellulitis.</p><p><strong>Conclusion: </strong>CD contributes to higher risks of atopic dermatitis and cellulitis. Additionally, psoriasis is suggestively associated with CD. Nonetheless, further research is warranted to confirm these findings and to elucidate the underlying mechanisms.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1757-1768"},"PeriodicalIF":2.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}