Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"The Causal Relationship Between Circulating Metabolites and the Risk of Atopic Dermatitis: A Two-Sample Mendelian Randomization Study.","authors":"Jian Chen, Dan Jian, Bingxue Bai","doi":"10.2147/CCID.S484813","DOIUrl":"https://doi.org/10.2147/CCID.S484813","url":null,"abstract":"<p><strong>Background: </strong>Previous research has shown that metabolites (especially lipid-related metabolites) have a significant influence in the development of atopic dermatitis (AD). However, there is no evidence of a causal connection between metabolites and AD risk. The specific mechanisms require further elucidation. Our study employed a two-sample Mendelian randomization (TSMR) strategy to investigate how metabolite traits affect AD.</p><p><strong>Methods: </strong>Utilizing publicly accessible GWAS data, we conducted TSMR studies to investigate the relationship between 233 metabolites traits (213 lipid-related traits and 20 no lipid-related traits) and AD. Our TSMR study primarily employed the Inverse-variance weighted method and four ancillary methods to analyze causation. Sensitivity analysis was performed to guarantee the TSMR results were trustworthy. Reverse MR analysis was used for investigating reverse causality.</p><p><strong>Results: </strong>After analyzing GWAS datasets for metabolites and AD, 13 metabolites were identified as positive. The MR analysis result indicates that total cholesterol in very small VLDL, cholesterol esters in very small VLDL, free cholesterol in IDL, concentration of medium LDL particles, concentration of large LDL particle, concentration of chylomicrons and extremely large VLDL particles, triglyceride levels in chylomicrons and extremely large VLDL, total lipid levels in chylomicrons and extremely large VLD, phospholipid levels in chylomicrons and extremely large VLDL, phospholipids in medium LDL, phospholipids in large LDL, phospholipids in small LDL, ratio of 18:2 linoleic acid to total fatty acids exhibited negative effects on AD. Reverse MR result analysis found that ratio of 18:2 linoleic acid to total fatty acids in serum was decreased in patients with AD. Sensitivity analyses ensure the stability of our results.</p><p><strong>Conclusion: </strong>These findings highlight a definite correlation between metabolite and AD, demonstrating the significant role of 13 lipid-related metabolite traits. Our results significantly reduced the influence of unavoidable confounders and reverse causality. Our findings may set the framework for prospective therapeutic approaches and call for further investigation to validate them.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"567-577"},"PeriodicalIF":1.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Causal Relationships Between Gut Microbiota, Inflammatory Cytokines, and Inflammatory Dermatoses: A Mendelian Randomization Study.","authors":"Zirui Huang, Tao Lu, Jiahua Lin, Qike Ding, Xiaoting Li, Lihong Lin","doi":"10.2147/CCID.S496091","DOIUrl":"https://doi.org/10.2147/CCID.S496091","url":null,"abstract":"<p><strong>Background: </strong>Some studies have established a link between gut microbiota, inflammatory proteins, and inflammatory dermatoses. However, the mediating role of inflammatory proteins in the gut-skin axis remains unclear.</p><p><strong>Methods: </strong>Data on inflammatory proteins and gut microbiota were drawn from the GWAS catalog and MiBioGen consortium, with inflammatory skin disease data provided by the FinnGen consortium. Using genome-wide association studies (GWAS), we performed linkage disequilibrium score regression (LDSC) to assess genetic correlations and conducted a two-step Mendelian Randomization (MR) analysis to investigate circulating inflammatory proteins as potential mediators between gut microbiota and inflammatory dermatoses.</p><p><strong>Results: </strong>MR analysis identified 38 gut microbiota and 23 inflammatory proteins associated with inflammatory skin diseases. After false discovery rate (FDR) correction, four gut microbiota taxa-<i>Eubacterium fissicatena, Bacteroidaceae, Allisonella</i>, and <i>Bacteroides</i>, remained statistically significant (OR = 1.32, 95% CI: 1.16-1.50, <i>adjusted P</i> = 0.007; OR = 2.25, 95% CI: 1.48-3.42, <i>adjusted P</i> = 0.026; OR = 1.42, 95% CI: 1.18-1.70, <i>adjusted P</i> = 0.014; OR = 2.25, 95% CI: 1.48-3.42, <i>adjusted P</i> = 0.013), with only IL-18R1 significantly associated with eczema (OR = 1.05, 95% CI: 1.03-1.08, <i>adjusted P</i> = 0.017). Further mediation analysis showed that IL-15RA mediated 11% of the pathway between <i>Veillonellaceae</i> and eczema, while FGF19 mediated 6% of the pathway between genus <i>LachnospiraceaeUCG001</i> and psoriatic arthritis.</p><p><strong>Conclusion: </strong>These findings provide potential targets for therapeutic interventions in inflammatory skin diseases.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"579-592"},"PeriodicalIF":1.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cathepsins and Skin Cancer (Malignant Melanoma, Basal Cell Carcinoma, and Squamous Cell Carcinoma): Insight From Genetic Correlation and Mendelian Randomization.","authors":"Xianglong Li, Shaofeng Yang, Zhong Du, Wanying Xie, Man Zhu, Ling Han, Qingyu Zhou","doi":"10.2147/CCID.S502013","DOIUrl":"https://doi.org/10.2147/CCID.S502013","url":null,"abstract":"<p><strong>Background: </strong>Multiple studies have indicated that cathepsins (Cats) play a crucial role in the development and progression of skin cancer. However, most of these studies are observational and may be influenced by external variables, necessitating further research to establish causal relationships.</p><p><strong>Methods: </strong>We conducted a two-sample, two-way Mendelian randomization (MR) study utilizing pooled data from genome-wide association studies (GWAS) to evaluate the causal association between 9 Cats (Cat-B, E, F, G, H, L2, O, S, and Z) and 3 types of skin cancer, including malignant melanoma (MM), basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Our analysis employed several methods, including inverse variance weighting (IVW), MR-Egger, weighted median, Cochran's <i>Q</i> test, the MR-Egger intercept test, and leave-one-out sensitivity analysis. Furthermore, bioinformatics analysis of loci linked to Cats and skin cancer was performed to explore potential molecular mechanisms.</p><p><strong>Results: </strong>Genetically predicted increases in Cat-F and Cat-O levels were found to be correlated with a higher risk of BCC, while increased levels of Cat-L2 and Cat-O were associated with a reduced incidence of SCC. Bioinformatics analysis suggested that differentially expressed genes located near Cats-related loci could potentially influence BCC and SCC by modulating relevant signaling pathways and the tumor microenvironment.</p><p><strong>Conclusion: </strong>Our research indicated a causal link between Cats and skin cancer. By conducting a bioinformatic analysis of genetic loci related to Cats and skin cancer, we were able to gain a better understanding of the potential molecular mechanisms driving this association. This research can provide valuable insights into the diagnosis and treatment of skin cancer.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"553-566"},"PeriodicalIF":1.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Safety of the Use of 1470 nm Laser Therapy in Patients Suffering From Acne Scarring of the Facial Skin.","authors":"Paweł Kubik, Stefano Bighetti, Luca Bettolini, Wojciech Gruszczyński, Bartłomiej Łukasik, Stefania Guida, Giorgio Stabile, Elisa Maria Murillo Herrera, Andrea Carugno, Edoardo D'Este, Nicola Zerbinati","doi":"10.2147/CCID.S510208","DOIUrl":"https://doi.org/10.2147/CCID.S510208","url":null,"abstract":"<p><strong>Purpose: </strong>This prospective, single-center, open-label study aimed to evaluate the efficacy and safety of 1470 nm non-ablative laser therapy in treating facial acne scars. The primary objective was to assess improvements in skin texture, elasticity, and scar depth and diameter, while confirming the absence of significant adverse effects.</p><p><strong>Patients and methods: </strong>40 healthy female volunteers aged 18 to 42 years with facial acne scars underwent three sessions of 1470 nm laser therapy at two-week intervals. Outcome measures included cutometric assessments, high-frequency ultrasound evaluations, and clinical photographic documentation, conducted at baseline and on days 21, 42, 70, and 130 post-treatment.</p><p><strong>Results: </strong>Significant improvements were observed across all evaluated parameters. Skin elasticity increased progressively from baseline (mean: 62.95, SD=4.0) to day 21 (63.72, SD=3.8, +4%), day 42 (67.11, SD=4.0, +6%), day 70 (69.08, SD=4.2, +11%), and day 130 (70.80, SD=4.4, +14%; p<0.001). High-frequency ultrasound measurements revealed substantial reductions in scar depth, which decreased by 5% at day 21 (mean: 0.18 mm, SD=0.05, p<0.001), 20% at day 42 (0.15 mm, SD=0.055, p<0.001), 48% at day 70 (0.10 mm, SD=0.06, p<0.001), and 63% at day 130 (0.07 mm, SD=0.065, p<0.001). Scar diameter followed a similar trend, with reductions of 16% at day 21 (3.08 mm, SD=0.3, p<0.001), 26% at day 42 (2.71 mm, SD=0.34, p<0.001), 42% at day 70 (2.13 mm, SD=0.36, p<0.001), and 62% at day 130 (1.39 mm, SD=0.38, p<0.001). Clinical photographic evaluations corroborated these quantitative findings, showing visible improvements in scar appearance and overall skin texture. No adverse events were reported throughout the study.</p><p><strong>Conclusion: </strong>The 1470 nm non-ablative laser therapy demonstrated high efficacy and safety in the treatment of acne scars, delivering substantial therapeutic benefits and high patient satisfaction, offering a valuable therapeutic option for addressing both pigmentation and textural issues associated with acne scars.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"543-551"},"PeriodicalIF":1.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Applications of Chitosan in Seborrheic Dermatitis and Other Skin Diseases: A Comprehensive Review.","authors":"Youting Liu, Jianli Shang, Yong Chen, Xiaoyue Feng","doi":"10.2147/CCID.S504778","DOIUrl":"10.2147/CCID.S504778","url":null,"abstract":"<p><p>This review article explores the potential applications of chitosan, a natural polysaccharide derived from crustacean shells, in the treatment of seborrheic dermatitis (SD) and other skin diseases. SD is a common chronic inflammatory skin condition characterized by erythema, scaling, itching, and an oily appearance, predominantly affecting areas rich in sebaceous glands. Current treatments, including antifungal agents, corticosteroids, and calcineurin inhibitors, offer symptomatic relief but have limitations in long-term use due to side effects and resistance issues. Chitosan exhibits excellent biocompatibility, biodegradability, and broad-spectrum antibacterial properties, making it a promising candidate for SD treatment. This review highlights chitosan's multifunctional properties such as antimicrobial, anti-inflammatory, sebum-regulating, and barrier-enhancing effects, which are closely related to the pathogenesis of SD. Additionally, the article summarizes the applications of chitosan in other skin conditions, including wound healing, infectious skin diseases, and atopic dermatitis, demonstrating its broad therapeutic potential. Through this comprehensive evaluation, the review aims to provide a theoretical foundation for clinical research on chitosan in SD and support the development of new, safer, and more effective treatment options for various skin conditions.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"533-542"},"PeriodicalIF":1.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Retrospective Study of 51 Chinese Patients.","authors":"Xiaoxue Li, Yanmei Li, Lian Liu, Lian Wang, Lidan Zhang, Xian Jiang","doi":"10.2147/CCID.S486550","DOIUrl":"10.2147/CCID.S486550","url":null,"abstract":"<p><strong>Background: </strong>Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe and potentially lethal adverse drug reaction. Its clinical complexity and heterogeneity pose challenges for diagnosis and management.</p><p><strong>Methods: </strong>We retrospectively reviewed the medical records of patients with DRESS who were admitted to our hospital between 2013 and 2022. Data on demographics, culprit drugs, clinical manifestations, laboratory findings, and treatments were collected.</p><p><strong>Results: </strong>Fifty-one patients were included in the final analysis, with 16 probable and 35 definite cases. The most common causative drugs were antiepileptic drugs (15.7%), anti-tuberculosis drugs (15.7%), and Chinese herbs (9.8%). Common skin manifestations included extensive skin involvement (76.5%), facial edema (66.7%), polymorphic maculopapular lesions (66.7%), and exfoliation (56.9%). Eosinophilia and atypical lymphocytes were noted in 96.1% and 68.6% of the patients, respectively. The liver is the most frequently affected organ. Facial edema, extensive skin involvement, and atypical lymphocytes were correlated with higher Registry of Severe Cutaneous Adverse Reactions (RegiSCAR) scores (<i>P</i><0.05). DRESS induced by antiepileptic drugs, antituberculosis drugs, and Chinese herbs exhibited significant differences in platelet and lymphocyte counts, C-reactive protein (CRP) levels, and transaminase levels (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Clinical manifestations of DRESS are complex. Facial edema, extensive skin involvement, and atypical lymphocytes have emerged as significant diagnostic indicators.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"525-532"},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety Evaluation of 595 nm Pulsed Dye Laser Treatment in 120 Cases of Asian Infants With Port Wine Stain.","authors":"Yiqun Guo, Hua Jiang, Yizhou Jiang, Xiaoyun Tan, Haibo Li, Jiejun Xia, Zhen-Yin Liu","doi":"10.2147/CCID.S489305","DOIUrl":"10.2147/CCID.S489305","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the efficacy and safety of a 595 nm pulsed dye laser (PDL) for the treatment of port wine stain (PWS) in 120 Asian infant patients.</p><p><strong>Methods: </strong>A retrospective analysis was carried out to assess the efficacy and safety of 595 nm PDL in 120 Asian infant patients with PWS.</p><p><strong>Results: </strong>This study identified excellent (21.67%), good (23.33%), fair (30.83%), and poor (15.83%) clearance. Multiple treatments significantly improved efficacy, with 61.56% of patients achieving good or excellent responses after more than six sessions. Younger patients showed better treatment outcomes than older patients did. The lesion location influenced the response, with leg lesions exhibiting the poorest response. The pink lesions were the most susceptible, whereas the purple lesions displayed the least response. Smaller lesions (<10 cm²) showed a size-dependent excellent rate (41.0%) and lower poor rate (5.1%).</p><p><strong>Conclusion: </strong>The 595 nm PDL treatment displayed a favorable safety profile, with only mild, well-tolerated adverse effects. Rare adverse effects were resolved within 3-6 months. No severe adverse events were reported. The 595 nm PDL is safe and effective for Asian infant patients with PWS. The side effects were mild and well-tolerated by the patients.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"503-509"},"PeriodicalIF":1.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress in the Application of Molecular Hydrogen in Medical Skin Cosmetology.","authors":"Nan Guo, Yating Zhang","doi":"10.2147/CCID.S500255","DOIUrl":"10.2147/CCID.S500255","url":null,"abstract":"<p><p>Molecular hydrogen is a colorless, tasteless, biologically active small-molecule gas with reducing properties, demonstrating therapeutic and preventive effects across various human systems. Its mechanisms of action include selective antioxidation, anti-inflammatory effects, apoptosis inhibition, and the regulation of gene expression and signaling pathways. In the skin, molecular hydrogen reduces oxidative damage by scavenging free radicals and inhibiting oxidative stress, leading to improvements in texture and tone. It also regulates the inflammatory response, alleviating redness, itching, and discomfort, while promoting skin repair and regeneration. Moreover, hydrogen activates antioxidant enzymes in skin cells, boosting their antioxidant capacity and delaying aging. Clinical trials show that molecular hydrogen significantly improves conditions like acne, chloasma, and skin sensitivity. However, research in skin cosmetology remains in its early stages, with unanswered questions regarding mechanisms of action, optimal dosage, and long-term safety. Further investigation through clinical trials is essential for expanding its applications in this field. Molecular hydrogen holds significant promise in skin cosmetology, and as research and technology evolve, it is expected to drive innovations and breakthroughs in skin care. This review examines the therapeutic potential, mechanisms, and clinical applications of molecular hydrogen in skin cosmetology, addressing challenges and proposing pathways for future advancements in this field.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"511-523"},"PeriodicalIF":1.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887501/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584980","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of Injectable Hyaluronic Gel System on Skin Microbiota, Skin Defense Mechanisms and Integrity (Ex vivo Study).","authors":"Aleksei Y Prokopov, Zarema I Gazitaeva, Anna N Sidorina, Laurent Peno-Mazzarino, Nikita Radionov, Anna O Drobintseva, Igor M Kvetnoy","doi":"10.2147/CCID.S491685","DOIUrl":"10.2147/CCID.S491685","url":null,"abstract":"<p><strong>Objective: </strong>The influence of injectable hyaluronic gels on skin's microbiota is unclear. As well, skin microbiota is a key factor modulating final effect of injectable gels. The ex-vivo study was aimed at alterations following hyaluronic acid injection into the dermis in non-sterile skin surface conditions.</p><p><strong>Methods: </strong>Ex vivo human skin explants in the presence or absence of either <i>S. epidermidis or S. aureus</i>, were treated with either control excipient (0.9% sodium chloride) or test product (Hyaluronic acid injectable S, HA-S). Bacterial analysis was performed, as well as skin structural integrity. Histological imaging and immunostaining analysis in the presence of skin markers: epidermal (CD1a, Toll-like receptor 2 (TLR2), Beta-defensin-3 (BD3), CCN1) and dermal (DC-SIGN, Decorin) were then performed.</p><p><strong>Results: </strong>The injection of control excipient E and test product P, both associated with bacterial deposits, induced similar noticeable increase of <i>S. epidermidis</i> growth over 4 days, but no noticeable effect on growth of S. aureus. The injection of control excipient, associated with bacterial deposits, showed epidermal and dermal alterations increased with time. It was observed significant increase of epidermal CD1a, TLR2, CCN1 and dermal DC-SIGN, Decorin on Day 2. The injection of test product, associated with bacterial deposits, in contrast to injection of control excipient, associated with bacterial deposits, induced very slight but significant improvement of epidermal viability as well as significant decrease of epidermal TLR2, BD3, CCN1 and dermal DC-SIGN on Day 2.</p><p><strong>Conclusion: </strong>Our investigation showed that both intradermal injections, HA-based solution or control excipient, trigger short-term skin microbiota growth. We indicate strong influence of non-sterile skin surface conditions on human skin explant viability when skin barrier damaged by injection puncture and highlights differences of epidermal/dermal response depended on injected composition.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"459-473"},"PeriodicalIF":1.9,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioinformatics Analysis of Oxidative Stress-Related Genes and Immune Infiltration Patterns in Vitiligo.","authors":"Mingmei Yang, Huiying Wang, Ruzhi Zhang","doi":"10.2147/CCID.S496781","DOIUrl":"10.2147/CCID.S496781","url":null,"abstract":"<p><strong>Background: </strong>Vitiligo is an autoimmune disorder characterized by pigment loss, and current treatment options remain inadequate.</p><p><strong>Objective: </strong>This study aims to identify oxidative stress-related biomarkers and hub genes associated with vitiligo diagnosis through genomic analysis and to examine the role of immune cell infiltration in the pathogenesis of vitiligo.</p><p><strong>Methods: </strong>The mRNA expression profile dataset GSE75819 was retrieved from the GEO database. Differential expression of oxidative stress-related genes in vitiligo was analyzed using R software. Protein-protein interaction (PPI) analysis, gene ontology (GO), and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were conducted on the differentially expressed genes (DEGs). Immune cell infiltration between vitiligo and normal control groups was assessed using the CIBERSORT algorithm. Additionally, two machine learning algorithms were employed to identify hub genes, perform enrichment analyses, and evaluate their correlation with immune infiltration.</p><p><strong>Results: </strong>A total of 415 Oxidative Stress-DEGs were identified in vitiligo, including 317 up-regulated and 98 down-regulated genes. PPI analysis highlighted the significance of certain ribosomal protein genes. KEGG enrichment analysis suggested an association between vitiligo and various neurodegenerative conditions, particularly through pathways such as oxidative phosphorylation and ribosome biogenesis. GO enrichment analysis indicated that the hub genes were significantly enriched in mitochondrial-related activities. Significant differences in immune infiltration patterns were observed between vitiligo patients and normal controls. Machine learning algorithms identified oxidative stress-related key genes associated with vitiligo, notably the DCT gene, whose expression was strongly linked to the activity of specific immune cell subsets and melanin biosynthetic pathways.</p><p><strong>Conclusion: </strong>Oxidative stress-related DEGs, ribosomal proteins, immune infiltration, and hub genes related to melanin biosynthesis, particularly DCT, are closely associated with the pathogenesis of vitiligo. These findings enhance our understanding of vitiligo and may aid in identifying therapeutic targets for the disease.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"475-489"},"PeriodicalIF":1.9,"publicationDate":"2025-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11880687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143566236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}