Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Hair Transplantation on Free Flap in a Patient with Malignant Scalp Neoplasms: A Case Report.","authors":"Haiyan Shen, Yanwen Xu, Xiangsheng Wang, Jufang Zhang","doi":"10.2147/CCID.S543580","DOIUrl":"https://doi.org/10.2147/CCID.S543580","url":null,"abstract":"<p><p>This case report describes a pioneering approach to address severe alopecia following free flap reconstruction for malignant scalp tumor resection. A 41-year-old female with recurrent malignant fibrous histiocytoma underwent extensive scalp resection (10 cm × 21 cm defect) repaired with a free anterolateral thigh flap. While the flap healed successfully, the resulting baldness caused significant psychological distress, leading her to decline conventional scalp expansion due to its invasiveness. Instead, we performed staged autologous hair transplantation directly onto the flap-a technically challenging endeavor given the flap's thin skin, thick subcutaneous fat, and compromised vascularity. Using follicular unit extraction (FUE), the first session (2,289 grafts) followed partial flap resection, and the second session (2,571 grafts) was conducted 18 months later. Key adaptations included low-density implantation (30-40 FU/cm²), controlled graft depth, and tumescent solution to maintain skin tension. Follow-up revealed encouraging graft survival (~60% initially, rising to ~70% in the second session), achieving complete coverage at ~35 FU/cm² with no complications. The patient expressed high satisfaction with the natural aesthetic outcome. To our knowledge, this represents the first such case reported in China and only the third globally, demonstrating that staged FUE transplantation on free flaps is a viable, minimally invasive solution for post-oncologic alopecia when traditional methods are contraindicated or refused. This technique expands reconstructive options for patients prioritizing both cure and quality of life.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2681-2689"},"PeriodicalIF":2.2,"publicationDate":"2025-10-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12539423/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Nutritional Status and Severity of Atopic Dermatitis in Children in a Hospital Setting in Kinshasa, Democratic Republic of the Congo.","authors":"Lydie Mosongo Matandoko, Lydie Joelle Nono Seudjip, David Kanyinda Kayembe, Paulo Muntu Bunga, Simon Mazebo Paku","doi":"10.2147/CCID.S516535","DOIUrl":"https://doi.org/10.2147/CCID.S516535","url":null,"abstract":"<p><strong>Background and objective: </strong>Several authors have unanimously evaluated therelationship between obesity alone and atopic dermatitis (AD). The aim of the present study was to investigate the correlation between nutritional status and the severity of AD in Congolese children.</p><p><strong>Methods: </strong>A cross-sectional, descriptive study was conducted over 6 months (November 2023 to April 2024) at two sites selected for logistical reasons: University Clinics of Kinshasa and Ngaliema Medical Center, in the dermatology and pediatric consultation departments. The study population consisted of all children aged 0-18 years with atopic dermatitis. Statistical analyses were performed using SPSS 26.0, with a significance level of p<0.05.</p><p><strong>Results: </strong>Of 684 children examined, 259 (37.9%) had AD. The M/F sex ratiowas 0.8%. The median age was 6 years (3-11 years), with a higher proportion of children aged 0-5 years (53.3%). Moderate AD was more frequent (56%), without statistical significance. Severe malnutrition and underweight were protective factors against AD in the 0-5 and 6-18 age groups respectively [p = 0.985; OR 0.1 (0.01-0.2)].</p><p><strong>Conclusion: </strong>Nutritional status in atopic children has no impact on the expression of atopic dermatitis. Etiological studies of the case-control or prospective cohort type would enable this assertion to be verified.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2669-2680"},"PeriodicalIF":2.2,"publicationDate":"2025-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12537512/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"HaiTang Heji Formula for Moderate Rosacea Refractory to Conventional Therapies: A Case Report Demonstrating Holistic Improvement in Physical and Psychological Symptoms.","authors":"Xu Liu, Yu Wang, Yanbing Han, Qingfeng Liu, Linghong Guo, Xian Jiang","doi":"10.2147/CCID.S518165","DOIUrl":"10.2147/CCID.S518165","url":null,"abstract":"<p><p>Rosacea is a chronic inflammatory skin disease that significantly impacts patients' quality of life. Current treatments have limitations. We report a case of moderate papulopustular rosacea effectively treated with the Chinese herbal formula HaiTang Heji. A 34-year-old Asian woman with a 3-year history of recurrent facial erythema, papules, pustules, and flushing, refractory to conventional therapies, showed significant improvement after 16 weeks of HaiTang Heji 20mL tid. Investigator Global Assessment (IGA) decreased from 3 to 1, Global Flushing Severity Scale (GFSS) from 3 to 1, anxiety scores decreased from moderate to mild levels, and depression scores decreased from mild to minimal levels. The patient tolerated the treatment well with no reported adverse effects, highlighting the potential safety of this herbal formula. Response was largely maintained at 21-week follow-up. HaiTang Heji's therapeutic mechanisms may involve anti-inflammatory, immunomodulatory, anti-angiogenic, and gut-brain-skin axis modulation. Further research is warranted to confirm its efficacy and safety as an alternative rosacea treatment.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2663-2667"},"PeriodicalIF":2.2,"publicationDate":"2025-10-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12535717/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145336155","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus Recommendations for the Management of Androgenetic Alopecia in Egypt: A Modified Delphi Study.","authors":"Sara M Mohy, Mohamed F Abozeid, Wael M Seoudy, Ahmed Elshahid, Alaa E A Moubasher, Ashraf Hassan, Eman Elmorsy, Eman R M Hofny, Essamelden M Mohamed, Hanan Mohammed Saleh, Hanan Sabry, Khaled Gharib, Mohamed Abdelwahed Gaber, Mohamed Saad Hegazy, Mona A Atwa, Nayera Moftah, Nermeen Ibrahim Bedair, Noha Ezzat Mohammed, Samia Esmat, Tarek Ameen, Tarek Hussein, Yasser Mostafa Gohary, Mahmoud A Rageh","doi":"10.2147/CCID.S556881","DOIUrl":"10.2147/CCID.S556881","url":null,"abstract":"<p><strong>Background: </strong>Androgenetic alopecia (AGA) is a common dermatologic condition with significant psychological and social impact. Treatment remains challenging due to heterogeneity in patient response and limited long-term efficacy data.</p><p><strong>Objective: </strong>To develop expert consensus guidelines for the diagnosis and management of AGA tailored to the Egyptian population, considering region-specific clinical and systemic factors.</p><p><strong>Methods: </strong>A modified Delphi process was conducted in two rounds. Initially, a structured, evidence-informed questionnaire was distributed to 1,000 practicing dermatologists across Egypt; 723 completed the survey. Responses were analyzed and refined into consensus statements, which were subsequently evaluated by a panel of 20 senior dermatology professors. Statements achieving ≥75% agreement were considered consensus.</p><p><strong>Results: </strong>Twenty-seven consensus statements were established and categorized into seven key areas: diagnosis, minoxidil, antiandrogens, low-level laser therapy, adjuvant treatments, hair transplantation, and counseling/hair aids. These recommendations reflect a synthesis of current evidence and national clinical experience.</p><p><strong>Conclusion: </strong>This consensus provides a regionally relevant, evidence-based framework for AGA management in Egypt. It emphasizes individualized care, multidisciplinary strategies, and the integration of emerging therapies, and may serve as a model for practice in similar healthcare settings.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2651-2662"},"PeriodicalIF":2.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12533493/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Refractory Livedoid Vasculopathy with Upadacitinib: A Case Report.","authors":"Cuiqin Wang, Xiaobing Wang, Pingxiu He, Xiaohua Tao, Weijun Liu","doi":"10.2147/CCID.S556844","DOIUrl":"10.2147/CCID.S556844","url":null,"abstract":"<p><strong>Purpose: </strong>While tofacitinib, baricitinib, and abrocitinib demonstrate efficacy in livedoid vasculopathy (LV), this study evaluates upadacitinib-a distinct Janus kinase (JAK) inhibitor-in refractory LV.</p><p><strong>Patients and methods: </strong>A 54-year-old female with treatment-resistant LV received upadacitinib (15 mg/day). Treatment response was assessed via composite clinical scores pre- and post-therapy.</p><p><strong>Results: </strong>Significant improvement occurred within 24 days (score: 7→2), indicating remission. Pain intensity markedly decreased, and near-complete ulcer healing was observed by day 52. No adverse effects were observed, with the exception of orolabial herpes simplex.</p><p><strong>Conclusion: </strong>Upadacitinib represents a novel therapeutic alternative for LV. Larger cohorts are needed to validate these findings.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2645-2650"},"PeriodicalIF":2.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12533487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328281","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Relationships Between Plasma Metabolites and Risk of Dermatomyositis.","authors":"Wenyi Qin, Jiayu Tian, Yuqin Qiu, Xiaorong Bao, Shuangshuang Yang","doi":"10.2147/CCID.S538895","DOIUrl":"10.2147/CCID.S538895","url":null,"abstract":"<p><strong>Purpose: </strong>This exploratory study aimed to investigate the potential causal relationships between plasma metabolites and dermatomyositis using Mendelian randomization (MR), with the goal of generating hypotheses for future research.</p><p><strong>Patients and methods: </strong>We screened well-established metabolite GWAS databases and a comprehensive dermatomyositis patient database, starting with 1,400 metabolites. Suitable instrumental variables (IVs) were selected based on genome-wide significance, LD independence <i>(r²</i> < 0.01), and F-statistics > 10 to minimize weak instrument bias and pleiotropy. These IVs were then integrated with dermatomyositis patient data for MR analysis, employing techniques such as inverse-variance weighting (IVW), MR-Egger regression, and weighted median approaches. Sensitivity analyses were conducted to ensure result robustness, and findings were visualized using forest plots, scatter plots, and funnel plots.</p><p><strong>Results: </strong>The IVW method revealed 53 metabolites and metabolic ratios significantly associated with dermatomyositis. Specifically, 20 metabolites and 8 metabolic ratios were linked to a decreased risk, while 17 metabolites and 8 ratios indicated increased risk. However, none of these associations remained statistically significant after false discovery rate (FDR) correction. Notable heterogeneity was observed in Lactosyl-N-palmitoyl-sphingosine levels, and pleiotropy was evident with 3-carboxy-4-methyl-5-pentyl-2-furanpropionate (3-CMPFP). Robustness was confirmed through MR-PRESSO and leave-one-out analyses.</p><p><strong>Conclusion: </strong>This study conducted the first exploratory Mendelian randomization analysis to investigate potential causal links between plasma metabolites and dermatomyositis. Although no statistically significant causal relationships were identified after multiple testing correction, this study provides preliminary evidence and valuable hypotheses for further research into metabolic pathways underlying dermatomyositis.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2629-2643"},"PeriodicalIF":2.2,"publicationDate":"2025-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12533595/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145328253","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Social Avoidance and Psychosocial Factors in Young Adults with Acne in East China.","authors":"Fen Xu, Nor Aziyan Yahaya, Yunxian Zhou, Junya Chen, Jia Yin Ruan, Yue Sun, Mei-Chan Chong","doi":"10.2147/CCID.S549119","DOIUrl":"10.2147/CCID.S549119","url":null,"abstract":"<p><strong>Background: </strong>Acne is highly prevalent among young adults, and in East Asian contexts-where appearance standards, social media exposure, and the cultural construct of \"face\" (mianzi) are particularly prominent-visible skin lesions may incur amplified social burdens. However, evidence from China remains scarce regarding the key drivers of social avoidance in this population: specifically, whether anxiety, body image disturbance, income level, and lesion distribution exert independent effects, beyond the influence of acne severity itself. This study aims to fill this research gap by examining a sample of young adults with acne from East China.</p><p><strong>Objective: </strong>To investigate social avoidance and its associations with body image disturbance, anxiety, and sociodemographic factors in Chinese young adults with acne.</p><p><strong>Methods: </strong>A cross-sectional study of 201 acne patients (18-29 years) in East China assessed social avoidance (SADS-SA), body image (BIDQ), and anxiety (GAD-7). Pearson correlation analyzed associations among variables, and multivariable linear regression explored independent effects of social avoidance.</p><p><strong>Results: </strong>Mean social-avoidance score was 5.71±3.79 and correlated with BIDQ (r = 0.343, <i>P</i> < 0.01) and GAD-7 (r = 0.546, <i>P</i> < 0.01). In multivariable models, higher income (≥5000 CNY) was negatively associated with avoidance (B =-2.640; β=-0.288; <i>P</i> = 0.022), whereas combined facial/neck + torso was positively associated with avoidance (B = 1.098; β= 0.122; <i>P</i> = 0.040); torso-only was negatively associated with avoidance (B =-3.889; β=-0.175; <i>P</i> = 0.003). Anxiety showed the strongest independent association with social avoidance (B = 0.330; β= 0.458; <i>P</i> < 0.001), while body image disturbance showed no significant direct association (<i>P</i> = 0.053).</p><p><strong>Conclusion: </strong>In Chinese young adults with acne, anxiety is strongly associated with social avoidance-not acne severity itself. Higher income acts protectively, and combined facial/neck and torso distribution indicates greater risk. These findings support the integration of brief anxiety screening, targeted psychosocial interventions, and focused care for patients with visible lesions into dermatological care to reduce social avoidance.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2617-2627"},"PeriodicalIF":2.2,"publicationDate":"2025-10-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12523553/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145307092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflamed Skin, Burdened Heart: A Multidisciplinary Perspective on Atopic Dermatitis and Cardiovascular Health.","authors":"Chenghui Ma, Yikang Xu, Wenshuo Bai, Yulin Zou","doi":"10.2147/CCID.S552485","DOIUrl":"10.2147/CCID.S552485","url":null,"abstract":"<p><p>The diseases of both skin and cardiovascular are the most significant global medical challenges for their high rates of morbidity and mortality. Although not life-threatening, skin diseases significantly impair patients' quality of life and affect a large proportion of the population due to their chronic and persistent nature. Cardiovascular diseases are characterized by both a widespread prevalence and a high risk of mortality, posing a significant public health burden. As both skin diseases and cardiovascular diseases fall under the umbrella of inflammatory disorders, a degree of pathophysiological connection exists between them. Historically, the potential interplay between these seemingly unrelated conditions was largely overlooked. However, accumulating evidence in recent years has suggested that inflammatory skin diseases-particularly Atopic Dermatitis (AD)-may be associated with an elevated risk of adverse cardiovascular outcomes. This review therefore not only examines the emerging interdisciplinary links between AD and cardiology, but also highlights ongoing controversies, the limitations of current evidence, and outlines future research directions needed to clarify their shared inflammatory pathways and clinical implications.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2591-2604"},"PeriodicalIF":2.2,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12519999/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Relationships Between Popular Diets (Low-Calorie, Vegetarian, and Gluten-Free Diets) and Inflammatory Skin Diseases: A Mendelian Randomization Study.","authors":"Yan Yu, Shu Wang, Jinru Lin, Zijun Wu, Yiming Zhang, Ruijing Wang, Huiping Wang","doi":"10.2147/CCID.S538761","DOIUrl":"10.2147/CCID.S538761","url":null,"abstract":"<p><strong>Background: </strong>Inflammatory skin diseases including acne, atopic dermatitis, psoriasis, and psoriatic arthritis, and have become a major global public health concern. Diet's impact on inflammatory skin diseases has attracted significant attention. This study utilised the Mendelian randomization (MR) method to investigate the relationship between popular diets, such as low-calorie, vegetarian, and gluten-free diets, and several common inflammatory skin diseases.</p><p><strong>Methods: </strong>Our study employed five MR methods, including the inverse variance weighted (IVW), MR-Egger, simple mode, weighted median, and weighted mode. Sensitivity analysis was conducted to confirm the accuracy and reliability of the research findings.</p><p><strong>Results: </strong>The results revealed a positive causal relationship between low-calorie diets and the risk of psoriatic arthritis (odds ratio [OR]: 1.05; 95% confidence interval [CI]: 1.01-1.10; <i>p</i> = 0.008) but no significant association with other diseases. No significant association was observed between vegetarian or gluten-free diets and the diseases. The reliability of the conclusion was further validated through the MR-Egger regression, MR-PRESSO analysis.</p><p><strong>Conclusion: </strong>This study offers preliminary insights into the links between diet and inflammatory skin conditions, with future large-scale, multi-method research needed to validate these findings and inform dietary recommendations.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2605-2615"},"PeriodicalIF":2.2,"publicationDate":"2025-10-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12520000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145298936","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case Report of Dermatomyositis Accompanied by Blisters.","authors":"Tianming Ma, Xiaoqing Xiang, Runqun Liu, Xianwei Han","doi":"10.2147/CCID.S556507","DOIUrl":"10.2147/CCID.S556507","url":null,"abstract":"<p><p>We report a patient with dermatomyositis who developed blisters. The patient was a female, 51 years old. She came to our hospital because of edematous purplish erythema on the face, neck, trunk, and extremities that itched for 1 month. Histopathology of the lesions showed: squamous epithelial tissue, hyperkeratosis of the epidermis, mild thickening of the stratum spinosum, liquefaction and degeneration of the basal cells, perivascular lymphocytes in the dermis, plasma cell infiltration; myofibers of varying thicknesses, disappearance of transverse striations, and lymphocytic infiltration of interstitial muscles. Diagnosis: dermatomyositis. Water blisters appeared on the skin lesions of the patient with dermatomyositis. Given that the probability of dermatomyositis being accompanied by a tumor is approximately 10% - 20%, this is considered a serious condition by modern medicine. Therefore, we conducted a series of examinations, including immunohistochemistry, to determine the source of the blisters.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2541-2546"},"PeriodicalIF":2.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}