Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Successful Guselkumab Treatment in a Patient with Comorbid Psoriasis and Amyotrophic Lateral Sclerosis: A Case Study and Literature Review.","authors":"Jianxia Xiong, Xiaoli Chen, Kun Huang, Yun Pan","doi":"10.2147/CCID.S505143","DOIUrl":"10.2147/CCID.S505143","url":null,"abstract":"<p><p>Psoriasis is genetically influenced and can be triggered by factors such as infections, stress, and lifestyle. Chronic plaque psoriasis, the most prevalent form, involves key roles for IL-17 and IL-23 in its pathogenesis. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the degeneration of motor neurons, resulting in muscle weakness and atrophy. Currently, there is no cure for ALS, and treatment is symptomatic, aimed at improving quality of life. The combination of psoriasis and ALS is relatively rare. Although biologic agents have shown remarkable efficacy in the treatment of chronic plaque psoriasis, we have not found any case reports regarding the use of biologic agents for treating psoriasis accompanied by ALS. Our study presents a patient with severe plaque psoriasis and ALS who exhibited a positive response to Guselkumab, without worsening of ALS symptoms, suggesting a promising therapeutic strategy. This could provide a treatment option for patients with psoriasis combined with ALS.We conducted a comprehensive review of the literature on the comorbidity of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and ALS, with plaque psoriasis. This review highlights the differential impact of treatment modalities. Specifically, we found that TNF-α inhibitors may have adverse effects in MS but could provide protective benefits in AD and PD. In ALS patients with psoriasis, IL-17A and IL-23 inhibitors, exemplified by Guselkumab, are suggested as a more suitable alternative due to their lower risk of worsening ALS symptoms.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"735-741"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Association Between Serum Calcium, Potassium Levels, and Rosacea: Evidence from a Two-Sample Mendelian Randomization Study.","authors":"YanKun Zhang, Xuan Zhang, Jie Dong, Fang Liu","doi":"10.2147/CCID.S508231","DOIUrl":"10.2147/CCID.S508231","url":null,"abstract":"<p><strong>Purpose: </strong>Recent advances in epidemiological and genetic studies have provided some insights regarding the pathophysiology of rosacea, but the majority of its underlying mechanisms are still poorly understood. In particular, more data are needed to fully understand the role of micronutrients in rosacea development. This study aimed to explore the causality of associations between Calcium, Copper, Selenium, Zinc, Iron, Potassium and Magnesium with the risk of rosacea.</p><p><strong>Patients and methods: </strong>This was a two-sample Mendelian Randomization (MR) study that used data from genome-wide association studies (GWAS) on serum levels of selected micronutrients as exposure and rosacea as the outcome. The analysis primarily employed the Inverse Variance Weighted (IVW) method. Additional methods included weighted median, weighted mode, and MR-Egger regression. Sensitivity analysis included MR-Egger, MR-PRESSO, Cochran's Q, and leave-one-out methods. A total of 301 Instrumental Variables were selected for analysis.</p><p><strong>Results: </strong>The genetic prediction indicated a statistically significant association between serum Calcium levels and higher rosacea risk (Odds Ratio (OR) = 2.27, 95% Confidence Interval (CI): 2.02-2.55, P < 0.001), further confirmed by all supplementary MR methods. Significant association was also found between serum Potassium levels and lower rosacea risk (OR = 0.36, 95% CI: 0.14-0.93, P = 0.0354), further confirmed by the weighted-median method. Sensitivity analyses showed that the results were robust and not driven by any single factor, with low probability of horizontal pleiotropy.</p><p><strong>Conclusion: </strong>This study found an evidence of a causal association between genetically predicted serum levels of Calcium and Potassium with the risk of rosacea. The roles of these micronutrients should be further studied in rosacea, especially as a link to neurovascular dysregulation and oxidative stress.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"743-753"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Inflammatory Edema: A Frequently Overlooked Case of Pseudocellulitis.","authors":"Hendra Gunawan, Dini Atiyah, Retno Hesty Maharani, Yogi Faldian, Ravika Khaila Arrum","doi":"10.2147/CCID.S500048","DOIUrl":"10.2147/CCID.S500048","url":null,"abstract":"<p><p>Pseudocellulitis is a non-necrotizing inflammation of the dermis and hypodermis with a non-infectious etiology. One of the variants of pseudocellulitis is acute inflammatory edema (AIE), characterized by bilateral, erythematous, and edematous plaques, often found in critically ill patients. AIE is a rarely reported and frequently overlooked case of pseudocellulitis. Therefore, it needs to be differentiated from classic cellulitis, which has different management and prognosis. This case report aimed to present a case of AIE in a critically ill patient. A 71-year-old woman was admitted to intensive care with reddish swelling on four extremities. She was suffering from sepsis caused by pneumonia, congestive heart failure, tubulointerstitial disease, and hypoalbuminemia. A physical examination showed bilateral erythematous and edematous plaques that palpably felt warm. ALT-70 score was 4, indicating not likely true cellulitis. The patient was diagnosed with AIE and treated with a compression bandage, diuretics, and medications for underlying diseases. The lesions improved significantly on the second day of evaluation; unfortunately, respiratory failure caused the patient's death. Critically ill patients may have AIE misdiagnosed as cellulitis. Therefore, clinicians need to be well-versed in pseudocellulitis, especially AIE, to improve patient outcomes.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"729-733"},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Personality Traits and Motivations of Chinese Adults Seeking Cosmetic Botulinum Toxin Injection.","authors":"Chen Wang, Huan Qian, Mengwen Zhang, Chenggang Yi","doi":"10.2147/CCID.S511665","DOIUrl":"10.2147/CCID.S511665","url":null,"abstract":"<p><strong>Background: </strong>Cosmetic Botulinum toxin (BoTx) injection has become a popular trend. There is evidence that beauty seekers improve their self-esteem and psychological state through BoTx injection. However, the personality traits in Chinese patients with cosmetic injections have not yet been investigated.</p><p><strong>Objective: </strong>This study aimed to investigate the motivations and personality profiles of patients seeking cosmetic BoTx injections using the Eysenck Personality Questionnaire (EPQ).</p><p><strong>Methods: </strong>The present study used a cross-sectional design, and was conducted with a sample of 195 randomly selected patients seeking BoTx treatment. All participants completed the EPQ. We also provide options listed to explore patients' motivations for seeking treatment. The demographic information was collected and analysed.</p><p><strong>Results: </strong>A total of 195 patients were enrolled, with a mean age of 33.09 ± 8.70 years. Of the 195 participants, 177 (90.77%) were women and 18 (9.23%) were men. The mean age of the participants was 33.09 ± 8.70 years, and the majority (74.36%) had a bachelor's degree or higher. We investigated three injection options, including lower facial contour treatment, anti-aging wrinkle injection, and body slimming injection. The EPQ of all participants showed higher E and N scores, but lower P and L scores compared to the norms. The participants age below 30 of lower facial contour injection had significantly higher P scores (p=0.048) and N scores (p=0.004), while N scores of anti-aging wrinkle treatments were significantly lower (p=0.013).</p><p><strong>Conclusion: </strong>Our study was the first using EPQ to depict the personality traits of Chinese adults seeking cosmetic BoTx injection. Initially, we questioned the purpose of aesthetic treatment in the Chinese population, which were more affected by psychological factors. Identifying personality traits before injection will assist physicians in providing a psychologically matched treatment plan while improving treatment satisfaction. These findings suggest that understanding patients' personality traits can help physicians better predict treatment expectations and preferences. For example, patients with high neuroticism scores may be more anxious about treatment outcomes, so physicians can provide more detailed pre-treatment counseling and postoperative follow-up, which is crucial for improving treatment satisfaction and reducing potential medical disputes.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"709-719"},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological Subtypes and Clinical Presentation of Seborrheic Keratosis: A 15-Year Retrospective Analysis of 1,169 Cases in Hainan, China.","authors":"Wen Luo, Yujia Liang, Xianxu Yang, Weiwei Wu, Jiejie Lu","doi":"10.2147/CCID.S517318","DOIUrl":"10.2147/CCID.S517318","url":null,"abstract":"<p><strong>Background: </strong>Seborrheic keratosis (SK), the most common benign epithelial tumor, frequently presents with cosmetic concerns despite its benign nature. The clinicopathological features of SK may demonstrate notable geographical variability. Diagnosis remains challenging due to varied clinical presentations.</p><p><strong>Objective: </strong>This study aimed to investigate the clinicopathological characteristics of SK through a comprehensive analysis of a large patient cohort.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of clinical and pathological data from 1,169 patients diagnosed with SK between 1 January 2009 and 31 December 2023. Histopathological subtypes were categorized, and a descriptive analysis of demographic and clinical characteristics was performed.</p><p><strong>Results: </strong>A total of 1,169 SK specimens were identified. The most frequent histopathological subtype was the acanthotic type (79.86%, 960 cases), followed by melanoacanthoma (7.98%, 92 cases), adenoid (5.32%, 64 cases), hyperkeratotic (4.90%, 59 cases), irritated (1.74%, 21 cases), and clonal (0.004%, 6 cases). The male-to-female ratio was 1.3:1, with a higher prevalence in men. SK most commonly affected the head, face, and neck, which accounted for 54.58% of cases (656/1,169), followed by the trunk (28.87%, 347 cases) and extremities (11.48%, 138 cases). The perineal area accounted for 4.48% (54 cases), while mucosal and plantar lesions were rare. The acanthotic subtype predominated across all anatomical sites, including mucosal and plantar regions. The age group most frequently diagnosed with SK was 40-59 years, with the acanthotic, melanoacanthoma, and adenoid types being particularly prevalent in this cohort. The clinical-pathological diagnostic concordance rate was 55.69%, indicating a relatively high rate of diagnostic discrepancy based on visual examination alone.</p><p><strong>Conclusion: </strong>Our study confirms the acanthotic subtype as the most common histological type of SK, predominantly observed in patients aged 40-59 years. The head, face, and neck emerged as the most frequently involved sites. Ultraviolet radiation may play a significant role in SK pathogenesis.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"721-727"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report and Literature Review on Skin Toxicity Induced by PD-1 Inhibitor in a Penile Cancer with Massive Ulceration of Chemoradiotherapy-Resistant and Successful Treatment by Immunotherapy.","authors":"Yanyan Zhu, Daxia Cai, Jiangle Jiang, Jianfei Tu, Zhifeng Tian, Xiayan Zhang, Songmei Luo, Yonghui Wang","doi":"10.2147/CCID.S505045","DOIUrl":"10.2147/CCID.S505045","url":null,"abstract":"<p><p>Penile cancer is a rare malignant tumor with a poor prognosis in advanced stages. Immune checkpoint inhibitors (ICIs) have demonstrated promising efficacy in patients with advanced penile cancer, but it can also induce immune-related adverse events (irAEs). This article reports a patient who achieved almost a complete response to the PD-1 inhibitor sintilimab as third-line treatment for advanced penile squamous cell cancer with massive ulceration of chemoradiotherapy-resistant, and successful treatment by immunotherapy. One year into maintenance therapy with sintilimab, skin toxicity in the form or grade-2 skin rashes and grade-3 pruritus occurred. Sintilimab was permanently discontinued. The skin toxicity was effectively controlled by oral prednisone at a daily dosage of 15 mg. At the last follow-up of 16 months after sintilimab discontinuation, the patient remained in partial response, with total progression-free survival exceeding 30 months. We also conducted a comprehensive literature search, and summarized skin toxicity of ICIs administration. These articles suggested that immune-related skin toxicity may be indicative of good treatment response.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"699-707"},"PeriodicalIF":1.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Poor Lifestyle Habits and Cutaneous Melanoma Risk: A Mendelian Randomization Study.","authors":"Xiaohui Liu, Wenkang Luan, Shujun Fan, Tengfei Liu","doi":"10.2147/CCID.S506547","DOIUrl":"10.2147/CCID.S506547","url":null,"abstract":"<p><strong>Background: </strong>There is still no consensus on the risk factors of cutaneous melanoma, and the causal relationship between poor lifestyle habits (including undersleeping, smoking, alcohol consumption and sedentary behaviour) and cutaneous melanoma remains uncertain.</p><p><strong>Methods: </strong>We investigated the causal effect of poor lifestyle habits on cutaneous melanoma through the Two-sample Mendelian randomization (MR). MR analysis was performed by using the genome-wide association studies (GWAS) statistics. Single-nucleotide polymorphisms (SNPs) robustly associated with undersleeping, smoking, alcohol consumption and sedentary behaviour were used as instrumental variables, we performed five MR approaches, including inverse variance weighted (IVW), weighted median, simple mode, MR-Egger and weighted mode.</p><p><strong>Results: </strong>The causal relationship between undersleeping and cutaneous melanoma was discovered in IVW (OR = 1.018, 95% CI = 1.002-1.033, P = 0.025). However, the causal association between smoking, alcohol consumption, sedentary behaviour and cutaneous melanoma have not been found in all MR approaches.</p><p><strong>Conclusion: </strong>The MR analysis indicated that undersleeping is causally associated with the risk of cutaneous melanoma.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"687-697"},"PeriodicalIF":1.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Targets Related to Skin Aging: Based on eQTL and GWAS Datasets.","authors":"Hanping Shi, Xianwei Cao","doi":"10.2147/CCID.S508946","DOIUrl":"10.2147/CCID.S508946","url":null,"abstract":"<p><strong>Background: </strong>The aging of skin has important impact on various systems, and certain skin aging (SG) markers can not only help with early diagnosis, but also provide new ideas for pathophysiological research and treatment strategies.</p><p><strong>Objective: </strong>To identify target genes related to SG through bioinformatics technology and provide ideas for skin anti-aging.</p><p><strong>Methods: </strong>Differential expression genes (DEGs) related to SG were screened through transcriptome information from GEO datasets (GSE85358 and GSE670988). Based on eQTL and GWAS datasets, Mendelian Randomization (MR) analysis was applied to identify associations between gene expression and SG. Then, aging skin related important genes (AS-IGs) were obtained based on above two steps, and functional and pathway analyses were performed to explore the potential mechanisms AS-IGs in SG. Finally, the CIBERSORT evaluation was used to assess the infiltration of immune cells related to SG.</p><p><strong>Results: </strong>Seven AS-IGs were selected through intersection from 612 DEGs and 399 eQTL genes. Then, enrichment analysis results showed there were 60 GO terms may involved in the process of SG, like fatty-acyl-CoA metabolic process, while KEGG enrichment pathways identified mainly involved in mechanisms related to fatty acid metabolism, energy generation, and inflammation regulation. The CIBERSORT evaluation showed that NK cells resting were the main infiltrating cells.</p><p><strong>Conclusion: </strong>AS-IGs may play important roles in the process of SG in the body. These molecules involve multiple systems and mechanisms in the body, such as immune function, metabolic function, and neuroendocrine function.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"677-686"},"PeriodicalIF":1.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopic Features of Erosive Pustular Dermatosis of the Scalp: A Comparative Multicentric Retrospective Study in Bald and Hairy Patients.","authors":"Noemi Plozner, Enrico Zelin, Iris Zalaudek, Aimilios Lallas, Bianca Maria Piraccini, Michela Starace, Enzo Errichetti","doi":"10.2147/CCID.S514416","DOIUrl":"10.2147/CCID.S514416","url":null,"abstract":"<p><strong>Background: </strong>Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory disorder primarily affecting elderly individuals with bald or hairy scalps. It is often misdiagnosed due to clinical overlap with other scalp conditions. Dermoscopy is an invaluable diagnostic tool for hair and scalp disorders, but its utility in EPDS remains underexplored. This study aims to identify dermoscopic features of EPDS and compare them with differential diagnoses to improve non-invasive recognition.</p><p><strong>Materials and methods: </strong>A retrospective multicentric study was conducted across three Italian dermatological centers. Two cohorts, bald and hairy patients with histologically confirmed EPDS, were compared with controls diagnosed with conditions mimicking EPDS. Dermoscopic images at 10× magnification were analyzed by two independent evaluators using standardized criteria. Comparative analyses of dermoscopic features and interobserver agreement were performed, with statistical significance set at p<0.01.</p><p><strong>Results: </strong>A total of 116 patients [53 bald patients (28 with EPDS and 25 controls) and 63 hairy patients (32 with EPDS and 31 controls)] were included in the study. Among EPDS bald patients, linear-curved vessels (unspecific distribution) (78.6%), orange structureless areas (diffuse) (46.4%), and yellow scales/crusts (focal) were the main findings, whereas focal yellow scales/crusts (84.4%) and the \"peripheral horizontal hair\" sign (84.4%) turned out to be the most common features in EPDS hairy patients. Comparative analysis revealed linear-curved vessels (p<0.001), orange structureless areas (diffuse) (p<0.001) and non-follicular pustules (p=0.005) to be distinctive features of EPDS in bald patients, while yellow scales/crusts (focal), non-follicular pustules and \"peripheral horizontal hair\" sign (horizontally arranged hair whose proximal part of the shaft is seen through a thinned epidermis at the edge of alopecic areas) were related (p<0.001) to EPDS in hairy patients. Interobserver agreement was excellent (Kappa=0.81-0.83).</p><p><strong>Conclusion: </strong>Dermoscopy provides valuable diagnostic clues for EPDS, distinguishing it from other scalp disorders.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"669-676"},"PeriodicalIF":1.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abrocitinib Treatment for Localized Type of Generalized Pustular Psoriasis: A Case Report.","authors":"Zhili Yang, Jiejie Lu, Zhen Li","doi":"10.2147/CCID.S517299","DOIUrl":"10.2147/CCID.S517299","url":null,"abstract":"<p><p>Generalized Pustular Psoriasis (GPP) is a recurrent dermatological condition characterized by widespread erythematous plaques, scaling, and sterile pustules. Notably, in a subset of patients, these lesions manifest exclusively in localized areas. We report a case where abrocitinib was used to treat the localized type of GPP, achieving relatively good clinical efficacy and without obvious side effects. To date, there are no published reports on the use of abrocitinib for GPP treatment, either domestically or internationally, making this case a valuable reference for clinicians and researchers.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"663-668"},"PeriodicalIF":1.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}