Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"A Retrospective Analysis of Radiofrequency Microneedling for Melasma Management in the Japanese Population.","authors":"Akiko Imaizumi, Aira Fujimaki, Narendra Kumar","doi":"10.2147/CCID.S601440","DOIUrl":"https://doi.org/10.2147/CCID.S601440","url":null,"abstract":"<p><strong>Background: </strong>Melasma is a chronic pigmentary disorder with multifactorial pathogenesis and significant psychosocial impact. Although radiofrequency microneedling has emerged as a dermal-targeting adjunctive therapy, real-world evidence regarding its clinical effects and safety is limited.</p><p><strong>Objective: </strong>To evaluate the real-world clinical response and safety of POTENZA^TM radiofrequency microneedling for melasma treatment.</p><p><strong>Methods: </strong>A retrospective observational before-and-after study was conducted at a private dermatology center in Japan. Adult patients with clinically diagnosed melasma who underwent POTENZA^TM radiofrequency microneedling treatment were included in the analysis. Melasma severity was assessed using the modified Melasma Area and Severity Index (mMASI) score. Patient-reported satisfaction, qualitative clinical improvement, and adverse events were analyzed descriptively.</p><p><strong>Results: </strong>A total of 29 female patients (mean age, 45.2 ± 7.9 years) were included in the study. The median baseline mMASI score was 6 (IQR 4-12) and remained 6 (IQR 4-8) after treatment, with no statistically significant difference between the time points (p = 0.16). Overall, 26 patients (89.7%) demonstrated stable or improved mMASI scores post procedure. Percentage-based analyses showed substantial interindividual variability: 27.6% of patients achieved≥25% and ≥30% reductions in mMASI, and 10.3% achieved≥50% reduction. Patient satisfaction was reported in 62.1% of the cases. All patients experienced mild, transient erythema that resolved without sequelae, and no serious adverse events were observed.</p><p><strong>Conclusion: </strong>In this real-world study involving Japanese patients, POTENZA^TM radiofrequency microneedling demonstrated a favorable safety profile and provided clinically meaningful improvements in selected patients, supporting its role as a complementary treatment in multimodal melasma management.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"601440"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142691/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dendrobium and Orchidaceae Plants in Dermatology: A PubMed-Based Bibliometric Analysis and Mechanistic Overview.","authors":"Jianghua Hu, Shanhong Sun, Kun Gao, Jianqing Deng, Penglong Yu","doi":"10.2147/CCID.S605188","DOIUrl":"https://doi.org/10.2147/CCID.S605188","url":null,"abstract":"<p><strong>Purpose: </strong>Dendrobium (\"Shihu\") and other Orchidaceae plants have been investigated as adjunctive options for inflammatory dermatoses, wound repair, and topical skin care. However, clinically relevant evidence and safety information remain scattered across phytochemistry, experimental dermatology, biomaterials, and formulation science. This study used bibliometric methods to map publication patterns and identify themes most closely related to dermatologic mechanisms and safety reporting.</p><p><strong>Methods: </strong>PubMed was searched on January 19, 2026 using a reproducible query that combined Orchidaceae/Dendrobium terms with dermatology and clinical/safety concepts. Records indexed from January 1, 2006 to January 19, 2026 were exported in MEDLINE format and analyzed in R with bibliometrix (v4.3.0) to summarize annual output, contributions by countries and institutions, collaboration networks, source journals, author productivity, and term co-occurrence with burst detection.</p><p><strong>Results: </strong>The final dataset contained 103 records. Annual output increased over time and peaked in 2025 (n=24). China contributed the largest share of publications and occupied a central position in international co-authorship networks. The literature was distributed across 64 journals and covered constituent characterization, experimental models, and delivery/materials-oriented studies. Recent term evolution highlighted growing attention to oxidative stress, signal transduction, and wound repair, whereas safety-related terminology appeared less frequently.</p><p><strong>Conclusion: </strong>Research on Orchidaceae-derived constituents relevant to dermatology is expanding, but clinically oriented evidence remains limited and reporting is heterogeneous, particularly with respect to botanical authentication, extract/formulation characterization, clinically interpretable endpoints, and adverse-event documentation. Better clinical translation will require transparent composition reporting and prospective studies that combine mechanism-linked biomarkers with systematic safety assessment.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"605188"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142715/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thiopurine Methyltransferase Levels and Azathioprine Outcomes in Thai Patients with Cutaneous Autoimmune Diseases.","authors":"Purit Pureesrisak, Oraya Kwangsukstid, Pinnaree Kattipathanapong, Tanawatt Kootiratrakarn, Chonlaphat Sukasem, Dumrong Mairiang, Wenika Channakorn, Daraka Phainupong, Mingkwan Suphannaphong","doi":"10.2147/CCID.S596438","DOIUrl":"https://doi.org/10.2147/CCID.S596438","url":null,"abstract":"<p><strong>Background: </strong>Thiopurine methyltransferase (TPMT) is responsible for the inactivation of azathioprine, and is widely used to treat cutaneous autoimmune diseases. TPMT activity is inherited as an autosomal codominant trait and ranges from high to undetectable levels in different individuals. Low TPMT activity may result in a higher risk of adverse effects (AEs), whereas high TPMT activity may result in potential treatment failure.</p><p><strong>Objective: </strong>To assess TPMT levels in patients with cutaneous autoimmune diseases and evaluate the correlation between TPMT levels and AEs of azathioprine and clinical response in patients with pemphigus.</p><p><strong>Methods: </strong>A cross-sectional study was conducted in 300 patients with cutaneous autoimmune diseases. Blood samples were collected to identify TPMT levels by ELISA. In 10 patients with the lowest TPMT levels, subsequent PCR analysis for the <i>TPMT</i> genotype was performed.</p><p><strong>Results: </strong>Among 300 patients, pemphigus vulgaris was diagnosed in 93 (31%), lupus erythematosus in 93 (31%), pemphigus foliaceus in 39 (13%), bullous pemphigoid in 32 (10.7%), systemic sclerosis in 26 (8.7%), and other diseases in 17 (5.6%). The mean TPMT level was 84.9 ± 30.5 mU/mL. Alcohol consumption significantly correlated with lower TPMT levels (p = 0.005). TPMT levels were not correlated with AEs (p = 0.184). The <i>TPMT</i> genotype showed <i>TPMT*1/*1</i> (wild-type) in all 10 patients with the lowest TPMT levels. In the pemphigus group, the TPMT level did not correlate with clinical response (p = 0.363).</p><p><strong>Conclusion: </strong>Alcohol consumption resulted in lower TPMT levels. TPMT levels did not correlate with clinical response in the pemphigus group and AEs. These findings provide real-world clinical insight in Thai patients, where routine TPMT screening is not universally implemented, highlighting the need for alternative predictors of azathioprine toxicity.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"596438"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142687/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Abrocitinib in Atopic Dermatitis Presenting with Hand-Foot Eczema and Nail Dystrophy: A Case Report.","authors":"Anqi Ma, Yongqiong Deng","doi":"10.2147/CCID.S596189","DOIUrl":"https://doi.org/10.2147/CCID.S596189","url":null,"abstract":"<p><p>Eczema-associated nail dystrophy is an uncommon but clinically relevant manifestation of atopic dermatitis (AD), which can lead to substantial structural and functional impairment and impose significant therapeutic challenges. However, evidence regarding systemic treatment for AD-related nail involvement remains limited. We report a case of AD presenting predominantly with refractory hand and foot eczema and marked nail dystrophy who achieved notable improvement following treatment with the selective Janus kinase 1 (JAK1) inhibitor abrocitinib, with cutaneous symptoms improving within several weeks after dose escalation and both fingernail and toenail abnormalities showing gradual structural recovery over a 12-month follow-up. Furthermore, the treatment was well tolerated throughout the follow-up period. This case suggests that abrocitinib may represent a promising therapeutic option for eczema-associated nail changes in patients with AD.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"596189"},"PeriodicalIF":2.2,"publicationDate":"2026-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13142689/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A <i>Ganoderma lucidum</i> Extract Improves Mitochondrial Function in Aging Skin and Promotes Wound Healing.","authors":"Li Tao, Meiling Tai, Zhuang Zhou, Zhenwen Chen, Rongjinlei Zhang, Yuanlong Ge, Zhenyu Ju","doi":"10.2147/CCID.S596475","DOIUrl":"https://doi.org/10.2147/CCID.S596475","url":null,"abstract":"<p><strong>Purpose: </strong>This study investigates whether <i>Ganoderma lucidum</i> extract (GLE) can enhance mitochondrial function to promote wound healing in aging skin.</p><p><strong>Methods: </strong>Natural senescent human foreskin fibroblasts (BJ) were treated with varying concentrations of GLE, and safe concentrations were determined using the cell counting kit-8 (CCK-8) assay. The levels of mitochondrial reactive oxygen species (ROS) and mitochondrial membrane potential (MMP) were measured. Animal experiments were conducted to validate GLE's effects on wound healing by assessing adenosine triphosphate (ATP) and ROS levels in skin tissues.</p><p><strong>Results: </strong>GLE exhibited no cytotoxicity within a concentration range of 0-100 µg/mL. Simultaneously treating senescent BJ cells with 50 µg/mL or 100 µg/mL of GLE can significantly enhance cell viability. Treatment with 100 µg/mL GLE significantly increased MMP levels while reducing mitochondrial ROS levels. Hydrogel containing 2% GLE applied to injured skin promoted wound healing, increased the ATP level of the wound tissue, and decreased ROS levels in skin tissues.</p><p><strong>Conclusion: </strong>These findings suggest that GLE can improve mitochondrial function in aging skin and promote wound healing.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"596475"},"PeriodicalIF":2.2,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13138277/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetically Predicted t⁶A (a tRNA-Derived Adenosine Modification) and Risk of Bullous Pemphigoid: A Two-Sample Mendelian Randomization Study.","authors":"Lulu Yan, Dan Chen, Dehou Yu, Xiaoping Shen","doi":"10.2147/CCID.S564082","DOIUrl":"https://doi.org/10.2147/CCID.S564082","url":null,"abstract":"<p><strong>Purpose: </strong>Bullous pemphigoid (BP) is an autoimmune blistering disease linked to T-lymphocyte dysregulation. Adenosine deaminase (ADA) and adenosine metabolites modulate T-cell function, suggesting a potential role in BP pathogenesis. However, causal evidence from human genetic studies is lacking. This study aimed to investigate the potential causal associations of genetically predicted levels of ADA, ADA protein, and several adenosine metabolites with the risk of BP and its subtypes (mucous membrane pemphigoid [MMP] and other/unspecified pemphigoid [OUP]).</p><p><strong>Patients and methods: </strong>We conducted a two-sample Mendelian randomization (MR) study using summary statistics from large-scale genome-wide association studies (GWAS). Genetic instruments for ADA levels, ADA protein levels, 5-methylthioadenosine, N1-methyladenosine, N6-carbamoylthreonyladenosine (t⁶A), and N6-succinyladenosine were selected. Outcome data for BP, MMP, and OUP were obtained from the FinnGen R12 release. The primary analysis used the inverse-variance weighted (IVW) method. Sensitivity analyses included MR-Egger, weighted median, weighted mode methods, Cochran's Q test, MR-Egger intercept test, MR-PRESSO, and leave-one-out analysis.</p><p><strong>Results: </strong>Genetically predicted higher t⁶A levels were significantly associated with a lower risk of BP (IVW OR: 0.37, 95% Confidence Interval [CI]: 0.21-0.66; P < 0.001; P_FDR < 0.001). This association was supported by the weighted median method (OR: 0.39, 95% CI: 0.18-0.86; P = 0.02). No significant evidence of heterogeneity or horizontal pleiotropy was found for this association. No causal associations were observed for other adenosine metabolites, ADA levels, or ADA protein levels with BP, MMP, or OUP after FDR correction.</p><p><strong>Conclusion: </strong>This MR study suggests a potential causal association between higher t⁶A levels and reduced risk of bullous pemphigoid. Further research is warranted to elucidate the underlying mechanisms and potential therapeutic implications.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"564082"},"PeriodicalIF":2.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135095/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811900","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morbihan Disease May Induce Nonspecific Inflammatory of Extra-Facial Region: A Case Report and Literature Review.","authors":"FeiFang Deng, Peng Wang","doi":"10.2147/CCID.S596249","DOIUrl":"https://doi.org/10.2147/CCID.S596249","url":null,"abstract":"<p><p>This case describes a 29-year-old man with Morbihan disease, characterized by a 5-year history of recurrent facial erythema, papules, and pustules, followed by persistent right face edema. Initially misdiagnosed as lupus erythematosus, he received multiple treatments with only transient relief. Clinical manifestations combined with pathological findings confirmed a diagnosis of Morbihan disease associated with rosacea. Notably, the patient developed erythema and papules on the inner thighs, along with small papules on the trunk and upper limbs for 3 months. A biopsy revealed nonspecific inflammation. Since the morphology of these lesions differed from any known skin disease and no other cause could be identified, we believe this may be a manifestation of the disease. Extra-facial manifestation not previously reported. Various therapies were attempted: doxycycline and azelaic acid improved erythema; baricitinib was ineffective; while omalizumab and intense pulsed light (IPL) achieved partial improvement in erythema and edema. Long-term isotretinoin therapy provided sustained remission without relapse during tapering, confirming its efficacy and safety. This case expands the clinical spectrum of Morbihan disease by documenting extra-facial involvement and reported isotretinoin as an effective long-term therapy, with omalizumab and IPL as promising adjuncts. Furthermore, the literature review (2004-2025) summarizes the clinical features, pathology, and treatment responses of reported cases, showing a male-to-female ratio of 2.81:1. Lymphatic or vascular dilation was significantly correlated with a favorable outcome. Conversely, dermal edema and granuloma were inversely associated with treatment efficacy, indicating poorer prognosis. However, based on uncontrolled data, these findings are strictly hypothesis-generating and do not establish a definitive treatment hierarchy.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"596249"},"PeriodicalIF":2.2,"publicationDate":"2026-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13135094/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811934","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Genetics of Hidradenitis Suppurativa.","authors":"Aditya K Gupta, Daniel J Dennis, Vasiliki Economopoulos, Renata Ferreira Magalhaes, Ditte Marie Lindhardt Saunte, Vincent Piguet","doi":"10.2147/CCID.S592693","DOIUrl":"https://doi.org/10.2147/CCID.S592693","url":null,"abstract":"<p><p>Hidradenitis suppurativa (HS) is a chronic, relapsing inflammatory skin disease characterized by painful nodules, abscesses, tunnels, and scarring, with substantial clinical and psychological burden. Genetic studies have revealed that HS has a complex and heterogeneous architecture, encompassing rare monogenic mutations, intermediate-frequency variants, and polygenic risk distributed across multiple loci. Familial aggregation, twin studies, and genome-wide association studies collectively demonstrate that inherited factors contribute substantially to disease susceptibility. Different genetic profiles influence disease onset, severity, and clinical phenotype. Monogenic γ-secretase mutations are associated with early-onset, severe, and extensive disease, whereas polygenic risk shapes heterogeneous presentations and may modify disease trajectory. Genetic variants implicated in HS also intersect with systemic comorbidities including inflammatory bowel disease, spondyloarthritis, coronary artery disease, and diabetes, highlighting shared pathogenic pathways. Mechanistic insights indicate that dysregulated Notch and Wnt/β-catenin signaling; keratinization and epithelial differentiation are central drivers of genotype-informed clinical trials. Despite advances, many variants remain uncharacterized, and polygenic risk scores currently have limited predictive power. Integration of genetic findings with clinical, environmental, and longitudinal phenotypic data is therefore essential to inform risk assessment, patient stratification, and early intervention. This review synthesizes current knowledge on HS genetics, emphasizing genotype-phenotype correlations, comorbidity associations, and translated opportunities, and outlines research priorities needed to advance toward precision medicine approaches for HS.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"592693"},"PeriodicalIF":2.2,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroa Vacciniforme: When and How to Suspect It.","authors":"Chuan Yang, Renheng Zhu","doi":"10.2147/CCID.S600995","DOIUrl":"https://doi.org/10.2147/CCID.S600995","url":null,"abstract":"<p><p>Hydroa vacciniforme (HV) is a rare pediatric photosensitive dermatosis characterized by sun-induced recurrent lesions on exposed areas and subsequent atrophic scarring, with its pathogenesis remaining unclear. This report aims to improve clinicians' recognition of pediatric HV and provide practical references for its clinical diagnosis and management by detailing a typical case in a young child. We describe a 3-year-old male patient with recurrent erythema, blisters, erosion, crusts, and atrophic scars on the face, nasal dorsum, and auricles for over one year. His skin lesions worsened significantly after sun exposure, alleviated with strict photoprotection, and presented with obvious seasonal variations. A definitive diagnosis of HV was made based on the patient's typical clinical manifestations. The patient was treated with strict sun avoidance, oral vitamin B6, and topical fusidic acid, with notable clinical improvement during follow-up. This case highlights that the definitive diagnosis of pediatric HV relies on typical clinical manifestations combined with the exclusion of relevant differential diagnoses, which is crucial for the early identification and standardized management of this rare disease in young children.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"600995"},"PeriodicalIF":2.2,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13123563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Polarized Macro Photography versus Polarized Dermoscopy in Basal Cell Carcinoma: A Blinded Paired-Image Comparison.","authors":"Ozan Erdem, Vefa Aslı Erdemir, Buğra Burç Dağtaş, Ayşe Esra Koku Aksu, Sümeyre Seda Ertekin, Abdurrahim Yilmaz, Ece Gökyayla, Gülsüm Gençoğlan, Fatih Göktay, Mehmet Salih Gürel","doi":"10.2147/CCID.S605974","DOIUrl":"https://doi.org/10.2147/CCID.S605974","url":null,"abstract":"<p><strong>Background: </strong>Polarized dermoscopy (PD) is the established non-contact imaging modality for basal cell carcinoma (BCC). Cross-polarized macro photography (CPMP) applies analogous optical principles using widely available equipment, but its performance relative to PD has not been systematically evaluated.</p><p><strong>Objective: </strong>To compare dermoscopic feature visibility, image quality, and expert modality preference between CPMP and PD in BCC using a blinded, paired-image design.</p><p><strong>Methods: </strong>One hundred paired CPMP and PD images of histopathologically confirmed BCCs, acquired during the same clinical visit, were digitally masked to remove modality-revealing cues and reviewed in randomized side-by-side pairs. Feature visibility was assessed by three dermoscopists; image quality by a multidisciplinary panel using the DIQS-5 (a structured 5-point dermoscopic image quality scale); and modality preference by three dermatologists with varying CPMP familiarity across two blinded rounds with a washout period.</p><p><strong>Results: </strong>Feature visibility did not differ significantly for any established BCC criterion (all P > 0.05). CPMP scored significantly higher for depth of field and color fidelity (both P < 0.001); sharpness was comparable between modalities (P = 0.494). CPMP captured all lesions ≥1 cm in a single frame, whereas 41.5% of large lesions exceeded PD's field of view. The majority of raters preferred CPMP in both evaluation rounds, with phenotype-dependent patterns: CPMP was favored for pigment-rich lesions and PD for lesions with fine vascular structures.</p><p><strong>Conclusion: </strong>CPMP demonstrated feature visibility comparable to PD while offering measurable advantages in depth of field, field of view, and color rendering, suggesting complementary roles for these modalities in BCC imaging.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"605974"},"PeriodicalIF":2.2,"publicationDate":"2026-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13117832/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}