Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Successful Treatment of Ustekinumab-Associated Lichenoid Drug Eruption with Upadacitinib: A Case Report.","authors":"Manqi Xia, Jing Zhang, Xin Tian, Ziyan Chen, Jingyao Liang, Yumei Liu","doi":"10.2147/CCID.S513281","DOIUrl":"10.2147/CCID.S513281","url":null,"abstract":"<p><p>Ustekinumab is an antibody targeting the common p40 subunit shared by interleukin (IL)-12 and IL-23, demonstrating favorable efficacy in the treatment of psoriasis. Herein, we report the case of a 69-year-old male with psoriasis, managed with ustekinumab, who presented with a new cutaneous eruption. Biopsy findings were consistent with lichenoid drug eruption (LDE). The patient's condition was promptly managed by upadacitinib, a selective Janus kinase (JAK) inhibitor. Physicians need not be overly concerned about this rare adverse reaction. JAK inhibitors may offer new treatment options with an advantage of rapid onset of action for patients experiencing LDE induced by biologic therapies for psoriasis.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"801-804"},"PeriodicalIF":1.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974564/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Porokeratotic Eccrine Ostial and Dermal Duct Nevus: A Report of Rare Late-Onset Solitary Lesion.","authors":"Kasama Tejapira, Poonkiat Suchonwanit","doi":"10.2147/CCID.S513737","DOIUrl":"10.2147/CCID.S513737","url":null,"abstract":"<p><p>Porokeratotic eccrine ostial and dermal duct nevus (PEODDN) is a rare dermatological disorder with fewer than 100 reported cases. It is characterized by abnormal keratinization over the dilated acrosyringium, and is hypothesized to involve somatic mosaicism of the GJB2 gene. Typically presenting in early childhood with linearly distributed hyperkeratotic papules along the Blaschko line, PEODDN predominantly affects palms and soles. We report an atypical case of PEODDN in a 64-year-old woman who presented with an asymptomatic solitary nodule on her left foot that had been present for three months. Histopathological examination confirmed the diagnosis and revealed a characteristic cornoid lamella overlying the dilated acrosyringium. The lesion was successfully treated with a CO₂ laser, with complete resolution and no recurrence at one-month follow-up. This case highlights the importance of considering PEODDN in the differential diagnosis of solitary lesion in atypical locations, even in older adults, and contributes to the limited literature on the late-onset solitary presentation of this rare condition. Our comprehensive review of the literature provides insights into the pathogenesis, clinical variations, associated conditions, and treatment options of PEODDN, with the aim of guiding clinicians in managing this uncommon entity.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"791-796"},"PeriodicalIF":1.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11975000/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Relief with Upadacitinib: A Case Report of Palmoplantar Pustulosis in a Pediatric Patient.","authors":"Qinchen Gu, Chen Zhang, Zhimin Lin, Yiting Fu, Chen Li, Zhenhua Ying","doi":"10.2147/CCID.S494567","DOIUrl":"10.2147/CCID.S494567","url":null,"abstract":"<p><p>Palmoplantar pustulosis (PPP) is a chronic inflammatory skin disease with recurrent erythema, scales, and sterile pustules on the palms and soles. Treating PPP in children is difficult due to limited effective therapies, especially as there's a lack of data on upadacitinib use in children under 12.This article reports a pediatric PPP case. The patient had severe, recurring rashes that affected daily activities. Treated with upadacitinib for two months, she showed a significant therapeutic response.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"797-800"},"PeriodicalIF":1.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11974563/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143802787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cross-Reactivity: a Case of Paracetamol-Induced Generalized Bullous Fixed Drug Eruption Followed by Dipyrone-Induced Fixed Drug Eruption.","authors":"Yuanyuan Wang, Huan Xue, Hejun Dai, Lianjuan Yang","doi":"10.2147/CCID.S519460","DOIUrl":"10.2147/CCID.S519460","url":null,"abstract":"<p><p>A fixed drug eruption (FDE) is a recurring adverse drug reaction that manifests as lesions on the same cutaneous or mucosal sites after exposure to the causative drug. It is characterized by erythematous or violaceous, round-to-oval patches with a dusky center. With each recurrence, the number and size of lesions can increase, raising the risk for generalized bullous fixed drug eruption (GBFDE). GBFDE, a rare and severe variant, presents with widespread bullae accompanied by characteristic FDE lesions. Nonsteroidal anti-inflammatory drugs (NSAIDs) are among the primary causes of FDE. Although cross-reactivity between different groups of NSAIDs has been rarely reported in FDE cases, in this report we present a case of paracetamol-induced GBFDE followed by FDE triggered by cross-reactivity with dipyrone (metamizole).</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"785-789"},"PeriodicalIF":1.9,"publicationDate":"2025-04-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11972605/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Toddler Molluscum Contagiosum on the Nipple.","authors":"Maher Al-Muriesh, Suaad Al-Ghaithi","doi":"10.2147/CCID.S515324","DOIUrl":"10.2147/CCID.S515324","url":null,"abstract":"<p><p>This case presenting a rare occurrence of Molluscum contagiosum (MC) on the nipple of a nineteen-month-old toddler. Clinical and dermoscopy examination revealed yellowish papule consistent with Molluscum contagiosum (MC). The lesion was extracted using a 30-gauge syringe needle. After two months, a follow-up dermoscopy revealed total clearing. This case illustrates how uncommon MC is in unusual places, like toddler's nipple, and shows how useful dermoscopy is for making diagnosis and treatment easier.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"781-784"},"PeriodicalIF":1.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970283/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794781","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Criticality of Benzoyl Peroxide and Antibiotic Fixed Combinations in Combating Rising Resistance in <i>Cutibacterium acnes</i>.","authors":"Mahmoud Ghannoum, Ahmed Gamal, Ahmed Kadry, James Q Del Rosso, Linda Stein Gold, Leon H Kircik, Julie C Harper","doi":"10.2147/CCID.S506254","DOIUrl":"10.2147/CCID.S506254","url":null,"abstract":"<p><strong>Background: </strong>Antibiotic resistance is growing globally, with multiple countries reporting resistance in >50% of <i>Cutibacterium acnes</i> (<i>C. acnes</i>) strains. Combination formulations of an antibiotic and the antimicrobial benzoyl peroxide (BPO) may reduce this resistance risk, especially with prolonged use. This 4-part study tested susceptibility of 31 <i>C. acnes</i> clinical strains and development of resistance to antibiotics alone or combined with BPO.</p><p><strong>Methods: </strong><i>C. acnes</i> susceptibility to single-drug antibiotics was assessed via minimum inhibitory concentration (MIC) values obtained from epsilometer tests, with lower MIC indicating higher susceptibility. Susceptibility to fixed-dose antibiotic/BPO combination products was determined by measuring the zone of inhibition using the agar diffusion method, with larger diameter indicating increased bacterial inhibition. The effect (synergistic, additive, antagonistic, or indifferent [no interaction]) of combining clindamycin with BPO on <i>C. acnes</i> inhibition was evaluated using a checkerboard assay, wherein 2 test compounds are combined in varying concentrations. Resistance development was assessed using serial passage of bacterial cultures in increasing concentrations of clindamycin alone or in combination with BPO.</p><p><strong>Results: </strong>All tested antibiotics (clindamycin, doxycycline, erythromycin, and minocycline) exhibited similar activity. <i>C. acnes</i> susceptibility was variable, with some strains having elevated MIC values-an indication of resistance-against different antibiotics. For 6 strains resistant to clindamycin alone (inhibitory zone=0 cm), formulations with BPO enhanced activity against the same isolates (range: 0.8-2.2 cm). Of 7 acne-associated strains, combining clindamycin and BPO had an additive effect against 4, and no interaction against 3. Bacterial cultures repeatedly exposed to the combination of clindamycin and BPO did not develop antibiotic resistance, which occurred with exposure to clindamycin alone.</p><p><strong>Conclusion: </strong>Overall, antibiotic susceptibility was highly dependent on the <i>C. acnes</i> strain, and antibiotic formulations with BPO exhibited enhanced activity against less susceptible strains. Fixed combinations of BPO with an antibiotic may improve antimicrobial activity and protect against resistance development.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"755-766"},"PeriodicalIF":1.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970427/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mendelian Randomization Analysis Supports a Causal Relationship Between Circulating Inflammatory Proteins and Basal Cell Carcinoma.","authors":"Zhi-da Fu, Yao Wang, Hong-Li Yan, Jian-Hua Wu","doi":"10.2147/CCID.S521068","DOIUrl":"10.2147/CCID.S521068","url":null,"abstract":"<p><strong>Background: </strong>It has been shown that the Basal cell carcinoma (BCC) is associated with chronic inflammation of skin conditions, the circulating inflammatory protein levels may be a more intuitive index in response to inflammation, however, the cause-and-effect relationship between circulating inflammatory proteins and BCC is currently unknown.</p><p><strong>Methods: </strong>This study performed a Mendelian randomization (MR) analysis using the plasma inflammatory protein levels from a large genome-wide protein quantitative trait loci study as the exposure data, and the outcome data from a GWAS for BCC. Inverse variance weighed, MR-Egger, maximum likelihood ratio, and weighted median for assessing causality between inflammatory proteins and BCC. MR-Egger regression and Cochran's Q statistic were applied for sensitivity analysis and MRPRESSO was applied to exclude outliers. Inverse MR analysis was performed on inflammatory proteins found to be causally associated with BCC.</p><p><strong>Results: </strong>Six circulating inflammatory proteins with a causal relationship with BCC were obtained, including CCL4, was of a significant protective effect on BCC development. IL-18 and CCL28, were of suggestive protective effects on BCC development. CX3CL1, IL-17A, and CSF-1 were potential risk factors in the development of BCC. According to the results of reverse MR analysis, there is no significant causal relationship between BCC and the above-mentioned inflammatory proteins.</p><p><strong>Conclusion: </strong>This two-sample MR study revealed a strong association between circulating inflammatory proteins and the development of BCC. Specifically, CCL4, CCL28, IL-18, CX3CL1, IL-17A, and CSF-1 emerged as potential targets for prognostic evaluation and treatment of BCC. However, further experimental studies are needed to elucidate the specific mechanisms.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"767-779"},"PeriodicalIF":1.9,"publicationDate":"2025-03-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970273/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143794775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Guselkumab Treatment in a Patient with Comorbid Psoriasis and Amyotrophic Lateral Sclerosis: A Case Study and Literature Review.","authors":"Jianxia Xiong, Xiaoli Chen, Kun Huang, Yun Pan","doi":"10.2147/CCID.S505143","DOIUrl":"10.2147/CCID.S505143","url":null,"abstract":"<p><p>Psoriasis is genetically influenced and can be triggered by factors such as infections, stress, and lifestyle. Chronic plaque psoriasis, the most prevalent form, involves key roles for IL-17 and IL-23 in its pathogenesis. Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disorder characterized by the degeneration of motor neurons, resulting in muscle weakness and atrophy. Currently, there is no cure for ALS, and treatment is symptomatic, aimed at improving quality of life. The combination of psoriasis and ALS is relatively rare. Although biologic agents have shown remarkable efficacy in the treatment of chronic plaque psoriasis, we have not found any case reports regarding the use of biologic agents for treating psoriasis accompanied by ALS. Our study presents a patient with severe plaque psoriasis and ALS who exhibited a positive response to Guselkumab, without worsening of ALS symptoms, suggesting a promising therapeutic strategy. This could provide a treatment option for patients with psoriasis combined with ALS.We conducted a comprehensive review of the literature on the comorbidity of neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD), multiple sclerosis (MS), and ALS, with plaque psoriasis. This review highlights the differential impact of treatment modalities. Specifically, we found that TNF-α inhibitors may have adverse effects in MS but could provide protective benefits in AD and PD. In ALS patients with psoriasis, IL-17A and IL-23 inhibitors, exemplified by Guselkumab, are suggested as a more suitable alternative due to their lower risk of worsening ALS symptoms.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"735-741"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956893/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751486","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Genetic Association Between Serum Calcium, Potassium Levels, and Rosacea: Evidence from a Two-Sample Mendelian Randomization Study.","authors":"YanKun Zhang, Xuan Zhang, Jie Dong, Fang Liu","doi":"10.2147/CCID.S508231","DOIUrl":"10.2147/CCID.S508231","url":null,"abstract":"<p><strong>Purpose: </strong>Recent advances in epidemiological and genetic studies have provided some insights regarding the pathophysiology of rosacea, but the majority of its underlying mechanisms are still poorly understood. In particular, more data are needed to fully understand the role of micronutrients in rosacea development. This study aimed to explore the causality of associations between Calcium, Copper, Selenium, Zinc, Iron, Potassium and Magnesium with the risk of rosacea.</p><p><strong>Patients and methods: </strong>This was a two-sample Mendelian Randomization (MR) study that used data from genome-wide association studies (GWAS) on serum levels of selected micronutrients as exposure and rosacea as the outcome. The analysis primarily employed the Inverse Variance Weighted (IVW) method. Additional methods included weighted median, weighted mode, and MR-Egger regression. Sensitivity analysis included MR-Egger, MR-PRESSO, Cochran's Q, and leave-one-out methods. A total of 301 Instrumental Variables were selected for analysis.</p><p><strong>Results: </strong>The genetic prediction indicated a statistically significant association between serum Calcium levels and higher rosacea risk (Odds Ratio (OR) = 2.27, 95% Confidence Interval (CI): 2.02-2.55, P < 0.001), further confirmed by all supplementary MR methods. Significant association was also found between serum Potassium levels and lower rosacea risk (OR = 0.36, 95% CI: 0.14-0.93, P = 0.0354), further confirmed by the weighted-median method. Sensitivity analyses showed that the results were robust and not driven by any single factor, with low probability of horizontal pleiotropy.</p><p><strong>Conclusion: </strong>This study found an evidence of a causal association between genetically predicted serum levels of Calcium and Potassium with the risk of rosacea. The roles of these micronutrients should be further studied in rosacea, especially as a link to neurovascular dysregulation and oxidative stress.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"743-753"},"PeriodicalIF":1.9,"publicationDate":"2025-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11956733/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acute Inflammatory Edema: A Frequently Overlooked Case of Pseudocellulitis.","authors":"Hendra Gunawan, Dini Atiyah, Retno Hesty Maharani, Yogi Faldian, Ravika Khaila Arrum","doi":"10.2147/CCID.S500048","DOIUrl":"10.2147/CCID.S500048","url":null,"abstract":"<p><p>Pseudocellulitis is a non-necrotizing inflammation of the dermis and hypodermis with a non-infectious etiology. One of the variants of pseudocellulitis is acute inflammatory edema (AIE), characterized by bilateral, erythematous, and edematous plaques, often found in critically ill patients. AIE is a rarely reported and frequently overlooked case of pseudocellulitis. Therefore, it needs to be differentiated from classic cellulitis, which has different management and prognosis. This case report aimed to present a case of AIE in a critically ill patient. A 71-year-old woman was admitted to intensive care with reddish swelling on four extremities. She was suffering from sepsis caused by pneumonia, congestive heart failure, tubulointerstitial disease, and hypoalbuminemia. A physical examination showed bilateral erythematous and edematous plaques that palpably felt warm. ALT-70 score was 4, indicating not likely true cellulitis. The patient was diagnosed with AIE and treated with a compression bandage, diuretics, and medications for underlying diseases. The lesions improved significantly on the second day of evaluation; unfortunately, respiratory failure caused the patient's death. Critically ill patients may have AIE misdiagnosed as cellulitis. Therefore, clinicians need to be well-versed in pseudocellulitis, especially AIE, to improve patient outcomes.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"729-733"},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954481/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}