Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Dupilumab as Immunomodulatory Rescue for Severe Recalcitrant Pemphigus Vulgaris: A Case Report and Literature Review.","authors":"Suphagan Boonpethkaew, Kumutnart Chanprapaph","doi":"10.2147/CCID.S535496","DOIUrl":"https://doi.org/10.2147/CCID.S535496","url":null,"abstract":"<p><p>Standard treatment of pemphigus vulgaris (PV) includes corticosteroid, immunosuppressants, and biologics such as rituximab, a monoclonal antibody targeting CD20⁺ B cells. However, some patients develop resistance to rituximab, requiring alternative therapeutic approaches. We report a 15-year-old female with severe PV who developed rituximab refractoriness after an initially effective response. Despite treatment with a combination of intravenous immunoglobulin, corticosteroid, and immunosuppressants, the patient failed to achieve disease control. Consequently, dupilumab, an interleukin-4 receptor α antagonist, was initiated on a biweekly regimen. Her lesions showed dramatic improvement, with the pemphigus disease area index (PDAI) reaching 0. Her anti-desmoglein 1 antibody level became negative, and T helper (Th)-2 inflammatory markers, including eosinophil count and immunoglobulin E (IgE) level, was normalized, allowing corticosteroid tapering after the 8th dose (last dose) of dupilumab. She has maintained complete remission for at least 28 weeks with regular follow-ups. We additionally propose possible mechanisms underlying rituximab refractoriness and how dupilumab modulates this treatment response. Our case highlights dupilumab's potential in modulating Th-2-driven autoantibody production for PV patients with high peripheral eosinophils and IgE levels who have severe disease resistant to corticosteroids or rituximab.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1775-1782"},"PeriodicalIF":2.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306637/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness of Photodynamic Therapy, 2% Salicylic Acid, and Their Combination for Moderate Acne.","authors":"Liping Li, Yan Huang, Jindong Lai, Xinyu Lin","doi":"10.2147/CCID.S532029","DOIUrl":"https://doi.org/10.2147/CCID.S532029","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the effectiveness of photodynamic therapy combined with 2% salicylic acid for treating moderate acne.</p><p><strong>Methods: </strong>This retrospective study included outpatients with moderate acne who consulted the Department of Dermatology at Suining First People's Hospital in Sichuan Province between April 2019 and December 2019. The patients were grouped into the photodynamic group, the salicylic acid group, and the combination therapy group, according to whether they received aminolevulinic acid photodynamic therapy, a 2% supramolecular salicylic acid topical masque applied once daily for 10 minutes and then washed off for four consecutive weeks, 2% salicylic acid therapy, or both treatments combined. The overall effective rate was calculated as the percentage of patients with a 60% or greater reduction in skin lesions. Adverse reactions were also collected.</p><p><strong>Results: </strong>A total of 66 patients were included, with 22 patients in each group. The combination therapy group had an overall effective rate of 72.73%, which was higher compared to the photodynamic group at 40.91% and the salicylic acid group at 22.73% (5 cases, <i>P</i> < 0.003). The skin lesions decreased in the photodynamic group, salicylic acid group, and combination therapy group by 11.72±4.80%, 8.62±3.16%, and 15.12±7.61% (<i>P</i>=0.01) at week one; 26.26±5.52%, 24.19±5.88%, and 33.11±8.90% (<i>P</i>=0.01) at week two; 42.63±7.25%, 39.21±9.91%, and 47.31±9.15% (<i>P</i>=0.01) at week three; and 58.84±9.45%, 52.35±8.75%, and 65.97±7.20% (<i>P</i>=0.01) at week four. Some patients experienced mild discomfort (redness, itching, pain), but no severe adverse reactions were reported.</p><p><strong>Conclusion: </strong>Photodynamic therapy combined with 2% salicylic acid therapy reduced the number of skin lesions in patients with moderate acne more than either treatment alone. The combination therapy may be tolerable with no severe adverse reactions.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1783-1790"},"PeriodicalIF":2.2,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12306566/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Celiac Disease and Skin Diseases: A Bidirectional Mendelian Randomization Study.","authors":"Chenyang Ge, Yizheng Wang, Xuegang Zhao, Jiawen Hao, Jing Zhang, Mengyuan Lu, Congying Li, Jianke Feng, Qingfu Zhang","doi":"10.2147/CCID.S533378","DOIUrl":"10.2147/CCID.S533378","url":null,"abstract":"<p><strong>Background: </strong>Research as shown that celiac disease (CD) is associated with skin diseases, but their causality remains unclear. Therefore, this Mendelian randomization (MR) study evaluated the causality between CD and skin diseases.</p><p><strong>Methods: </strong>Bidirectional MR analysis was performed on single nucleotide polymorphism (SNP) candidates identified from genome-wide association study (GWAS) datasets using inverse variance weighted (IVW), weighted median, MR-egger, weighted mode and simple mode. Multivariate MR (MVMR) analysis was subsequently conducted by adjusting for BMI, smoking, and alcohol use. Result reliability was assessed by horizontal pleiotropy and heterogeneity testing.</p><p><strong>Results: </strong>IVW analysis revealed that CD increased the risk of atopic dermatitis (OR = 1.042, 95% CI: 1.018-1.067, <i>P</i> = 5.75 × 10^-4) and cellulitis (OR = 1.026, 95% CI: 1.006-1.046, <i>P</i> = 9.18×10^-3). Additionally, psoriasis had a suggestive association with CD (OR=0.836, 95% CI: 0.710-0.983, <i>P</i> = 0.031). MVMR analysis demonstrated that CD had a direct effect on atopic dermatitis and cellulitis.</p><p><strong>Conclusion: </strong>CD contributes to higher risks of atopic dermatitis and cellulitis. Additionally, psoriasis is suggestively associated with CD. Nonetheless, further research is warranted to confirm these findings and to elucidate the underlying mechanisms.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1757-1768"},"PeriodicalIF":2.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301113/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Micro-Focused Ultrasound on an Individual with Titanium Facial Implants: A Case Report.","authors":"Dissapong Panithaporn","doi":"10.2147/CCID.S533425","DOIUrl":"10.2147/CCID.S533425","url":null,"abstract":"<p><strong>Introduction: </strong>Both micro-focused ultrasound (MFU) and monopolar radiofrequency (MRF) interventions are relatively safe and well tolerated as a non-invasive approach to achieve rejuvenating effects, with patients reporting limited adverse effects. However, MRF uses an electrical current which can induce heating in metal, potentially causing burns or thermal injury in the skin or tissue around the implant, whereas MFU delivers focused high-energy ultrasound, which does not induce electrical currents in metal.</p><p><strong>Case presentation: </strong>This report describes the case of a 28-year-old Thai male, who received titanium implants in the mandible bone, the mandible chin, the maxillary bone and the zygoma bone, seven years before. Because of his wish for a more sculpted and lifted facial appearance, the patient was treated with Ulthera Legacy in 2021 and with Ulthera Prime in 2024. With Ulthera Prime, visualization has significantly improved, which decreased the need to skip areas, leading to improved, more consistent results.</p><p><strong>Conclusion: </strong>This case study suggests that Ulthera Prime could be an option for skin firming and lifting effects for people with facial implants. Further research will be needed to corroborate this finding in a larger population.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1769-1773"},"PeriodicalIF":2.2,"publicationDate":"2025-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12301124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Development of a Cutaneous Horn on a Lower Extremity with Granuloma Annulare: A Rare Co-Occurrence.","authors":"Xiaolin Bu, Liwei Feng, Jing Guo, Rongzhu Yu, Xinling Bi","doi":"10.2147/CCID.S520386","DOIUrl":"10.2147/CCID.S520386","url":null,"abstract":"<p><p>A 65-year-old Asian male presented with a circular skin lesion on the flexor aspect of the right calf that first appeared at age 13 and gradually expanded peripherally. Six months prior to presentation, a dark brown, horn-like keratotic lesion with a hard texture emerged on the annular lesion, growing progressively without pain or pruritus. The cutaneous horn was surgically excised, and the annular lesion underwent biopsy. Pathological findings revealed abundant mucin in dermal collagen, dense histiocyte infiltration, and focal mild collagen degeneration, confirming a diagnosis of granuloma annulare complicated by a cutaneous horn.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1753-1756"},"PeriodicalIF":2.2,"publicationDate":"2025-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12288219/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyaluronic Acid Combined with Diluted and Hyperdiluted Calcium Hydroxylapatite to Treat the Periocular Area.","authors":"Julieta Spada, Jani Van Loghem","doi":"10.2147/CCID.S518475","DOIUrl":"10.2147/CCID.S518475","url":null,"abstract":"<p><strong>Purpose: </strong>A combination of fillers and other modalities is often required to address all signs of periorbital aging. Patients are injected for volume loss, and for hyperpigmentation are treated with a combination treatments with chemical peels and lasers, but multiple visits can be burdensome. To streamline the current treatment approach for the periocular area, the current study investigated the benefit of the treatment with a blend of Hyaluronic Acid (HA) and Calcium Hydroxylapatite (CaHA). This dual-filler strategy is designed to utilize the rheological and volume replacement capabilities of HA alongside the bioregenerative effects of CaHA while avoiding excessive edema and/or delayed swelling that may occur when HA is injected alone.</p><p><strong>Methods: </strong>One hundred and six adults were treated with a blend of crosslinked HA (22.5 mg/mL) and diluted/hyperdiluted CaHA. The filler ratio was chosen based on individual skin thickness and depth of palpebro-malar groove (PG) or supraorbital hollowness (SH). Assessments were performed at baseline (T0), 30, 60, 90, and 365 days. One patient underwent a comparative analysis of HA alone versus the HA-CaHA blend, evaluated through ultrasound, Magnetic Resonance Imaging (MRI) and Computed Tomography (CT) scan post-injection.</p><p><strong>Results: </strong>All treated patients presented natural-looking results, less pronounced PG and SH with minimal edema on D30, and skin quality improvement with less laxity, wrinkling and pigmentation. No hyaluronidase injections for overcorrections were required. No severe complications were observed. For most patients, results varied according to the dilution of the blend; lower dilutions (1:1) lasted longer than higher dilution (1:4), even though results were still noticeable for patients treated with the latter (1:4) at the 1-year evaluation.</p><p><strong>Conclusion: </strong>This study validates the use of a HA and CaHA blend (CaHA-CPM) for periocular rejuvenation, addressing various aging symptoms in this complex facial region.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1741-1752"},"PeriodicalIF":1.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278983/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682158","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Secondary Syphilis on Infant.","authors":"Zhe Cao, Zhen Hua Wang, Ai Juan Sun","doi":"10.2147/CCID.S515183","DOIUrl":"10.2147/CCID.S515183","url":null,"abstract":"<p><p>Secondary syphilis, a stage of sexually transmitted infection caused by Treponema pallidum, typically presents with a range of symptoms in adults. However, when this condition affects an infant, it becomes a rare and serious medical concern. This article explores a unique case of secondary syphilis in an infant, highlighting the diagnostic challenges, treatment options, and the importance of early intervention.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1737-1739"},"PeriodicalIF":1.9,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12278972/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144682157","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Link of Distinct Mental Disorders with Androgenetic Alopecia and Alopecia Areata: A Bidirectional Two-Sample Mendelian Randomization Study.","authors":"Chunyu Hu, Zhen Cheng, Yuanling Tao, Laixi Zhang, Yalan Zhang, Zongtao Chen","doi":"10.2147/CCID.S531734","DOIUrl":"10.2147/CCID.S531734","url":null,"abstract":"<p><strong>Background: </strong>The concern that mental states affect the hair-loss has been growing, but the causal evidence is still limited. We aimed to investigate whether and in which direction there is a causal link of distinct mental disorders with androgenetic alopecia (AGA) and alopecia areata (AA) in European population.</p><p><strong>Methods: </strong>We performed a bidirectional two-sample Mendelian randomization (MR) study to test their causality using summary statistics. The datasets of major depression disorder, anxiety disorder, panic attack, distress, and bipolar disorder were all accessed through the IEU OpenGWAS project. The datasets employed for AGA and AA analysis were sourced from the FinnGen release 10 databases, including 219,469 (220 AGA cases and 219,249 controls) and 394,872 (767 AA cases and 394,105 controls) participants, respectively. We utilized five extensively employed MR techniques to explore the bidirectional causal associations, including inverse variance weighted (IVW), weighted median, MR-Egger, weighted mode, and penalised weighted median.</p><p><strong>Results: </strong>Based on the IVW method, a bidirectional causal association was revealed whereby major depression disorder is associated with an increased risk of AA (OR: 1.59; 95% CI: 1.16-2.17) and vice versa (OR: 1.02; 95% CI: 1.00-1.03). Notably, the statistical power of MR estimates was both <80%. No association of any genetically predicted mental disorders with AGA was found. Sensitivity analyses substantiated the robustness and reliability of our findings.</p><p><strong>Conclusion: </strong>Our findings showed a bidirectional causal association between major depression disorder and AA, supporting the importance of therapies aimed at handling mental states for the prevention or treatment of AA rather than AGA.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1727-1736"},"PeriodicalIF":1.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mechanisms and Therapeutic Roles of Medicinal Plants in Skin Photoaging.","authors":"Xinxin Lei","doi":"10.2147/CCID.S538326","DOIUrl":"10.2147/CCID.S538326","url":null,"abstract":"<p><p>Photoaging refers to the cumulative skin damage primarily caused by exposure to ultraviolet (UV) radiation. This process results in the harmful effects of UV irradiation on skin cells, leading to alterations in the extracellular matrix, which consequently impacts the appearance and function of the skin. This review aims to elucidate how bioactive compounds from medicinal plants counteract UV-induced damage, as identified by current mechanistic and molecular studies. Over the past few decades, medicinal plants have garnered increasing attention for their potential therapeutic benefits in treating various human diseases. Numerous studies have explored the anti-photoaging properties of herbal remedies, revealing that various active compounds, extracts, and combinations of medicinal plants can mitigate photoaging in different skin cells through diverse signaling pathways. Compared to synthetic agents, herbal remedies offer lower toxicity profiles and are often perceived as safer alternatives, making them attractive options for long-term skin care and photoaging prevention. These findings suggest that herbal plants can reduce UV-induced skin damage primarily by inhibiting the production of reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and inflammatory mediators, while simultaneously promoting collagen synthesis. The underlying mechanisms of these effects are associated with key cellular pathways, including MAPK, NF-κB, Nrf2, and TGF-β/Smad. These findings suggest that herbal plants can reduce UV-induced skin damage by inhibiting reactive oxygen species (ROS), matrix metalloproteinases (MMPs), and inflammatory mediators, while promoting collagen synthesis. This review provides novel insight into cell-specific mechanisms by which medicinal plants mitigate photoaging, laying the groundwork for their potential therapeutic application.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1709-1726"},"PeriodicalIF":1.9,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12262069/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144642003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of Exosomes From Hypoxia-Induced Adipose-Derived Stem Cells on Ameliorating Photoaging.","authors":"Cuc Bach Huynh, Ngoc Bich Vu, Trung The Van, Phuc Van Pham","doi":"10.2147/CCID.S523936","DOIUrl":"10.2147/CCID.S523936","url":null,"abstract":"<p><strong>Introduction: </strong>Photoaging, a significant concern in cosmetic dermatology, involves complex skin damage that necessitates effective treatments. Exosomes derived from adipose-derived stem cells (ADSCs), particularly those generated under hypoxic conditions (hypADSC-Exo), have emerged as a promising cell-free therapeutic approach. This study investigates the effects of hypADSC-Exo on reducing human dermal fibroblast (HDF) senescence and mitigating signs of photoaging through topical application in a mouse model.</p><p><strong>Methods: </strong>Exosomes were isolated from hypoxia-induced human ADSCs via ultracentrifugation and identified using flow cytometry (CD9, CD63, CD81). Transmission electron microscopy (TEM) confirmed the vesicle morphology, while the Bradford assay and nanoparticle tracking analysis (NTA) assessed the protein content and size. In vitro, UV-induced senescent HDFs were treated with hypADSC-Exo. Cell morphology, senescence (SA-β-gal assay), proliferation (Alamar Blue), and gene expression (p16, p21 via qPCR) were evaluated. In vivo, photoaged mice received hypADSC-Exo treatments (50 or 100 μg/mL) twice weekly for six weeks. Skin parameters (wrinkles, thickness, hydration, elasticity) were evaluated biweekly. Skin biopsies were used to assess epidermal and dermal thickness, collagen density, and gene expression of collagen types 1, 3 and MMP-1, 2, and 3.</p><p><strong>Results: </strong>hypADSC-Exo exhibited a cup-shaped morphology under TEM and expressed exosomal markers CD9, CD63, and CD81. In vitro, hypADSC-Exo improved HDF morphology, reduced SA-β-gal activity, enhanced proliferation, and downregulated p16 and p21. In vivo, it reduced skin wrinkles and thickness. Treated mice exhibited improvement in hydration, elasticity, decreased epidermal and dermal thickness, and increased collagen density. Collagen types 1 and 3 increased slightly, while the levels of MMP-1, 2, and 3 decreased in the exosome group.</p><p><strong>Conclusion: </strong>Our findings demonstrate that hypADSC-Exo reduces senescence in UV-induced aged HDF and improves photoaging in mice. These effects likely result from decreased MMP-1, 2, 3 expression and increased collagen deposition, making hypADSC-Exo a promising therapy for photoaging.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1683-1702"},"PeriodicalIF":1.9,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12257001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144636447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}