Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"DNA Methylation at cg18095732 Modulates ZDHHC20 Expression and Decreases Acne Vulgaris Risk.","authors":"Ke Gong, Xiaotian Ji, Shuhui Wu, Dan Dan Zhao, Mingfang Zhu","doi":"10.2147/CCID.S552840","DOIUrl":"10.2147/CCID.S552840","url":null,"abstract":"<p><strong>Background: </strong>Acne vulgaris is a common chronic inflammatory skin disorder involving lipid metabolism and immune dysregulation. Protein S-palmitoylation regulates lipid homeostasis, while DNA methylation has emerged as a potential contributor to acne pathogenesis. Yet, how DNA methylation and palmitoylation intersect in acne remains unclear.</p><p><strong>Methods: </strong>The objective of this study was to investigate whether palmitoylation-related genes are causally linked to acne by integrating large-scale genetic and epigenetic datasets through Mendelian randomization and complementary analyses.</p><p><strong>Results: </strong>Our MR and SMR analyses identified ZDHHC20, a gene encoding a palmitoyltransferase, as significantly and negatively associated with acne risk. Further mediation analysis revealed that hypermethylation at the CpG site cg18095732 was positively associated with ZDHHC20 expression and indirectly contributed to a reduced risk of acne. This methylation site accounted for 61.90% of the total effect via mediation. Robustness of the findings was confirmed through sensitivity analyses, which indicated no evidence of horizontal pleiotropy or heterogeneity.</p><p><strong>Conclusion: </strong>This study provides supportive evidence for a regulatory pathway in which DNA methylation at cg18095732 up-regulates ZDHHC20 and is associated with lower acne susceptibility. Our findings highlight epigenetic regulation as a potential biomarker or intervention point for inflammatory skin disorders.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2579-2590"},"PeriodicalIF":2.2,"publicationDate":"2025-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12515450/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145285806","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Human Hair Absorption and Retention.","authors":"Jeonghoon Yun, Song Hee Kim, Hyeyeon Yoo, Keun Hyung Park","doi":"10.2147/CCID.S536755","DOIUrl":"10.2147/CCID.S536755","url":null,"abstract":"<p><strong>Objective: </strong>Adequate nutrition and moisture are crucial for preventing hair loss and maintaining hair health and appearance. Hair loss (alopecia) affects up to 50% of the population, causing significant social and psychological impacts. Despite the popularity of hair care products and their ingredients known to be beneficial, existing methods for evaluating the absorption of these substances into hair remain limited. This study assesses the absorption and retention of nutrients and moisture within human hair via 3D Raman spectroscopy.</p><p><strong>Methods: </strong>Three variables were structured for a double-arm study, involving untreated hair, water-treated hair, and hair treated with a supplemental hair care product. Hair samples were analyzed for absorption amount, depth, and dryness at 30 min intervals using Raman spectroscopy with 3D imaging technology.</p><p><strong>Results: </strong>Hair treated with hair care product indicated significantly higher in absorption amount, deeper penetration, and reduced dryness, confirmed by statistical analysis (<i>p</i> < 0.05). After 30 min of treatment, hair care product-treated samples maintained their absorption parameter, amount, depth and dryness (<i>p</i> < 0.05). This was further validated by the 3D Raman visualization which provided detailed spatial distribution and retention of absorbed substances within the hair fibers over time.</p><p><strong>Conclusion: </strong>These findings demonstrate the superior absorption and retention of hair care product in hair compared to untreated and water-treated hair, setting a new standard for evaluating hair absorption and product efficacy. Our method offers a promising tool for future clinical research and hair care product development.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2569-2578"},"PeriodicalIF":2.2,"publicationDate":"2025-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12513242/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145279074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Paradoxical Reaction in Cutaneous Tuberculosis: Insight from a Case of Lupus Vulgaris.","authors":"Hendra Gunawan, Risa Miliawati Nurul Hidayah, Reiva Farah Dwiyana, Yogi Faldian, Hermin Aminah Usman, Felix Tasbun","doi":"10.2147/CCID.S548020","DOIUrl":"10.2147/CCID.S548020","url":null,"abstract":"<p><strong>Introduction: </strong>Lupus vulgaris (LV) is the most common form of paucibacillary cutaneous tuberculosis (TB), which is treatable with antituberculosis treatment (ATT). Otherwise, paradoxical reaction (PR) is an adverse clinical consequence of restoring the specific antigen immune response elicited by ATT.</p><p><strong>Case presentation: </strong>We report a case of PR in a 20-year-old female patient with LV, who had previously completed treatment for meningitis and lymphadenitis TB and had a history of juvenile idiopathic arthritis (JIA). Initially, the patient presented with reddish papules on the neck, which appeared four months before consultation. The skin lesions progressively enlarged and failed to heal completely despite treatment, accompanied by knee joint pain. Physical examination revealed well-defined reddish-brown plaques measuring 1.5×1×0.1 cm on the neck and 5×3×0.5 cm beneath the right chin with gyrate borders. Diascopy tests revealed an \"apple jelly\" sign, while dermoscopy demonstrated yellowish-white globules on a pinkish-red background. Histopathological examination revealed tuberculoid granulomas, Langhans giant cells, and epithelioid cells with caseous necrosis. Based on these findings, a diagnosis of LV was established. However, bacteriological culture and polymerase chain reaction (PCR) testing showed no evidence of <i>Mycobacterium tuberculosis</i>. After three weeks of category I ATT, the skin lesions worsened and enlarged, suggesting the development of PR. The lesions subsequently improved two weeks after initiating additional therapy with 8 mg methylprednisolone twice daily and showed significant improvement following the addition of 200 mg hydroxychloroquine once a day.</p><p><strong>Conclusion: </strong>Although PR is rare, it should be considered in patients who demonstrate clinical deterioration after ATT. Clinicians should be aware of its occurrence in cutaneous TB, particularly LV, to ensure timely recognition and appropriate management.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2561-2567"},"PeriodicalIF":2.2,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499580/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Quantitative Image Analysis of Vascular Skin Response to Intense Pulsed Light Therapy.","authors":"Aleksandra Lipka-Trawińska, Anna Deda, Barbara Błońska-Fajfrowska, Agata Lebiedowska, Magdalena Hartman-Petrycka, Robert Koprowski, Dominika Wcisło-Dziadecka, Sławomir Wilczyński","doi":"10.2147/CCID.S545832","DOIUrl":"10.2147/CCID.S545832","url":null,"abstract":"<p><strong>Purpose: </strong>This study assessed the effectiveness of treatments using intense pulsed light (IPL) in reducing vascular lesions of the facial skin, such as erythema and telangiectasia.</p><p><strong>Patients and methods: </strong>The study involved 38 subjects aged 20 to 61 who underwent a series of 3 IPL procedures. In order to quantitatively assess the effects of therapy, advanced clinical photography techniques involving cross-polarized light and dedicated image analysis algorithms, ie GLCM (Gray-Level Co-occurrence Matrix) and QTDCOMP (Quadratic Tree Decomposition), were used.</p><p><strong>Results: </strong>The results indicate a significant reduction in vascular lesions after a series of treatments, which was confirmed by a statistically significant reduction in GLCM contrast and an increase in image homogeneity. Additionally, the use of quadratic tree decomposition allowed for the quantitative determination of skin homogeneity after therapy.</p><p><strong>Conclusion: </strong>The study has shown that image registration in cross-polarized light as well as GLCM and QTDCOMP analysis are effective tools for the objective and quantitative assessment of vascular skin lesions. These methods can be widely used in clinical practice to optimize the therapy of vascular lesions and monitor the effectiveness of IPL procedures.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2547-2560"},"PeriodicalIF":2.2,"publicationDate":"2025-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12499594/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145243818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perifollicular Elastolysis: A Case Report and Literature Review.","authors":"Jin-Yuan Ma, Xi Chen, You-Xue Wang, Xiao-Jin He, Ai-Hua Wei","doi":"10.2147/CCID.S542678","DOIUrl":"10.2147/CCID.S542678","url":null,"abstract":"<p><p>Perifollicular elastolysis (PE) is a rare acquired elastolytic disorder, first described by Varadi and Saqueton in 1970, characterized by focal loss of elastic fibers around hair follicles. It is frequently underrecognized and mistaken for common conditions like acne vulgaris. This case report describes an 18-year-old female presenting with asymptomatic, skin-colored papules diffusely distributed on the chest and back persisting for over a year. Dermatological examination revealed millet-sized, noninflammatory folliculocentric papules with smooth surfaces. Histopathology demonstrated perifollicular elastic fiber fragmentation and reduction on Verhoeff-Van Gieson staining, accompanied by mild perivascular inflammation, confirming PE diagnosis. The discussion synthesizes current understanding of PE's clinical spectrum, highlighting its differentiation from mid-dermal elastolysis (MDE), papular elastorrhexis, and other elastolytic disorders through histopathological hallmarks. While the exact pathogenesis of PE remains unclear, potential triggers include mechanical trauma, bacterial elastase activity, and autoimmune dysregulation. Current management focuses on minimizing mechanical trauma and topical therapies, though no standardized treatment exists. This case underscores the need for greater awareness of PE and calls for further research to elucidate its molecular mechanisms and develop evidence-based treatments for this benign yet cosmetically concerning condition.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2523-2529"},"PeriodicalIF":2.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495996/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Characteristics and Disease Course of Livedoid Vasculopathy: A 10-Year Retrospective Analysis.","authors":"Yali Gao, Yaling Li, Dilixiati Mairepati, Haijian Wu, Junfeng Liu, Jiande Han, Hui Zhou","doi":"10.2147/CCID.S549839","DOIUrl":"10.2147/CCID.S549839","url":null,"abstract":"<p><strong>Objective: </strong>Livedoid vasculopathy (LV) is a rare, chronic, recurrent thrombo-occlusive cutaneous disorder, which is also known as atrophie blanche (AB). Its characteristic clinical manifestations include livedo racemosa, painful ulcerations, and white atrophic scars predominantly on the lower extremities. This study aimed to investigate the clinical appearance, histological features and laboratory test results, treatment strategies, and clinical outcomes of LV to provide evidence for clinical diagnosis and management.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of clinical data from 69 LV patients diagnosed in the First Affiliated Hospital of Sun Yat-sen University between January 2014 and December 2024. Data encompassed demographic characteristics, clinical manifestations, histopathological features, laboratory investigations, treatment regimens, and follow-up results. Treatment efficacy was assessed based on ulcer healing time and patient-reported symptom improvement.</p><p><strong>Results: </strong>The median age was 31 years (range: 11-85 years), with females constituting 69.6% (48/69). Only 5 patients (7.3%, 5/69) received an initial diagnosis of LV. The predominant clinical presentations were recurrent painful ulcerations (89.9%, 62/69), white atrophic scars (82.6%, 57/69), purpura (84.1%, 58/69), livedo racemosa (75.4%, 52/69) and local pain (85.5%, 59/69) on the lower extremities. Treatment modalities primarily included anticoagulant therapy, antiplatelet therapy, corticosteroids, lipid-lowering therapy, immunosuppressive agents, traditional Chinese medicine and physical therapy modalities.</p><p><strong>Conclusion: </strong>LV predominantly affects young and middle-aged females. Combination therapy with anticoagulant, antiplatelet and corticosteroids significantly contributes to ulcer healing and rapid pain relief. Long-term follow-up is necessary to monitor for potential progression to systemic diseases. As a single-center retrospective study, these findings warrant further validation through multicenter prospective research.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2531-2540"},"PeriodicalIF":2.2,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12495966/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Specific Sleep Traits and Four Inflammatory Skin Diseases: A Mendelian Randomization Study.","authors":"Peiquan Yang, Yongyou Huang, Wencheng He, Tingjun Chen, Shenji Wei, Yuanqing Zhao","doi":"10.2147/CCID.S541688","DOIUrl":"10.2147/CCID.S541688","url":null,"abstract":"<p><strong>Background: </strong>Sleep disturbances, including insomnia and abnormal sleep duration, are increasingly recognized for their role in various inflammatory processes, yet their causal impact on inflammatory skin diseases remains unclear.</p><p><strong>Objective: </strong>This study aims to systematically explore the causal relationships between specific 8 sleep traits and 4 inflammatory skin diseases, including psoriasis, acne, atopic dermatitis, and urticaria.</p><p><strong>Methods: </strong>We conducted a two-sample Mendelian randomization (MR) analysis using genetic data from the UK Biobank and FinnGen. Genetic variants associated with the sleep traits, such as insomnia, sleep duration, daytime sleepiness, daytime napping, snoring, and chronotype, were selected as instrumental variables. We employed methods including inverse variance weighting, weighted median estimation, and MR Egger regression to ensure robust causal inference. Sensitivity analyses were conducted to assess heterogeneity and pleiotropy.</p><p><strong>Results: </strong>Notably, frequent insomnia was causally linked to an increased risk of psoriasis and atopic dermatitis, while longer sleep duration showed protective effects against acne and urticaria. Additionally, there was no strong evidence connecting other sleep traits like daytime sleepiness, napping, snoring, and chronotype to these skin conditions. Sensitivity analyses also confirmed the robustness and consistency of these findings across different methods.</p><p><strong>Conclusion: </strong>This study provides evidence that specific sleep traits, especially insomnia and sleep duration, have a causal impact on inflammatory skin diseases. Addressing sleep disturbances in dermatological care could be crucial for reducing disease severity and enhancing patient outcomes.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2509-2521"},"PeriodicalIF":2.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of Upadacitinib in the Treatment of Acquired Reactive Perforating Collagenosis in a Patient with Type 1 Diabetes: A Case Report and A Literature Review.","authors":"Jiehui Chen, Tao Deng, Maoying Li, Cuihong Lian","doi":"10.2147/CCID.S549157","DOIUrl":"10.2147/CCID.S549157","url":null,"abstract":"<p><p>Acquired reactive perforating collagenosis (ARPC) is a rare skin condition characterized by collagen loss through the epidermis. We report the first clinical use of the JAK inhibitor upadacitinib for treating ARPC in a 32-year-old woman with a 17-year history of type 1 diabetes, whose persistent pruritic lesions responded poorly to conventional treatments. The patient started a daily regimen of 15 mg upadacitinib and showed a rapid response within 2 weeks, with significant lesion flattening and no new eruptions. By week 4, her pruritus was fully resolved. By week 16, she transitioned to an every-other-day dosing schedule without adverse effects. This article reviews existing literature on JAK inhibitors in ARPC treatment, indicating favorable outcomes. However, given the characteristics of ARPC, sustained maintenance therapy with JAK inhibitors may be necessary. We also explore the potential role of the JAK-STAT signaling pathway in the pathogenesis of ARPC associated with different types of diabetes, suggesting that JAK inhibitors may offer new therapeutic options for diabetic patients with ARPC. The limitations of this article include a small sample size and a lack of cost-effectiveness analysis. Therefore, larger-scale studies are needed to validate the efficacy and safety of JAK inhibitors in the treatment of ARPC and to further investigate clinical differences among patients with various forms of diabetes complicated by ARPC.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2489-2494"},"PeriodicalIF":2.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493097/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Interleukin-1 Receptor Antagonist as a Potential Mediator Linking Psoriasis and Non-Alcoholic Fatty Liver Disease: Insights From Mendelian Randomization and Experimental Evidence.","authors":"Ce Shuai, Szeman Cheung, Li Zhang, Han Cao, Yongyong Yuan, Qinyi Ge, Youcong Wang, Xia Li, Jie Zheng, Feng Xue","doi":"10.2147/CCID.S536186","DOIUrl":"10.2147/CCID.S536186","url":null,"abstract":"<p><strong>Background: </strong>Epidemiological studies have revealed a close association between psoriasis and non-alcoholic fatty liver disease (NAFLD), but the causal relationship and underlying mechanisms remain unclear.</p><p><strong>Materials and methods: </strong>In this study, we used genome-wide association study (GWAS) data from the MRC Integrative Epidemiology Unit (MRC-IEU) to investigate the causal relationship between psoriasis and NAFLD, as well as potential mediators. Two-sample and two-step MR analyses were conducted, followed by bulk and single-cell transcriptomic analyses to validate our MR findings. In vivo validation was performed using Enzyme-Linked Immunosorbent Assay (Sample of patients (n=10)), immunohistochemistry, and liver bulk transcriptomic analysis.</p><p><strong>Results: </strong>The two-sample MR analysis revealed that genetically predicted psoriasis significantly increased the risk of NAFLD (OR = 1.07, 95% CI = 1.03-1.12, <i>p</i> = 0.001). Mediation analysis suggested that psoriasis was associated with elevated plasma Interleukin-1 receptor antagonist protein (IL-1RA) levels (OR = 1.02, 95% CI = 1.00-1.05, <i>p</i> = 0.031), which in turn raised the risk of NAFLD (OR = 1.15, 95% CI = 1.04-1.27, <i>p</i> = 0.006). In vivo experiments demonstrated elevated IL-1RA levels in the skin and plasma of psoriasis patients. Similarly, imiquimod (IMQ)-induced psoriasis mouse models exhibited increased IL-1RA levels in plasma and liver, accompanied by liver inflammation. MR and colocalization analysis indicated a positive correlation between IL-1RA, apolipoprotein B, and cholesterol.</p><p><strong>Conclusion: </strong>Our study demonstrates that genetically predicted psoriasis increases the risk of NAFLD, and plasma IL-1RA may serve as a potential mediator between psoriasis and NAFLD.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2495-2507"},"PeriodicalIF":2.2,"publicationDate":"2025-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12493115/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145231554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pseudoxanthoma Elasticum-Like Papillary Dermal Elastolysis (PXE-PDE) in an Elderly Female: A Rare Diagnostic Entity.","authors":"Naif Alshehri, Reem Alsergani, Abdulrahman Alqerafi, Sadan Mohammed Al Harbi, Ahmed Alhumidi, Mohammed A Alfada","doi":"10.2147/CCID.S548675","DOIUrl":"10.2147/CCID.S548675","url":null,"abstract":"<p><p>Pseudoxanthoma elasticum-like papillary dermal elastolysis (PXE-PDE) is a rare, acquired skin disorder characterized by multiple small papules arising from degeneration of elastic fibers in the dermis. It is often underrecognized due to its benign nature and resemblance to harmless age-related skin changes and may be misdiagnosed as conditions such as pseudoxanthoma elasticum (PXE). A 70-year-old woman presented with asymptomatic skin lesions on her neck, which had gradually increased over 2-3 years. On physical examination, multiple confluent yellowish-white papules with a cobblestone appearance were observed on the neck. Skin biopsy confirmed the diagnosis of PXE-PDE, showing loss of elastic tissue in the superficial dermis. The patient underwent two sessions of CO₂ laser treatment, with approximately 40% improvement noted by both the physician and the patient. This case underscores the importance of clinicopathologic correlation in diagnosing PXE-PDE and distinguishing it from PXE and other mimickers. CO₂ laser therapy may be considered as a cosmetic treatment option in selected patients.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2451-2455"},"PeriodicalIF":2.2,"publicationDate":"2025-09-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12482947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145205740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}