Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Pathophysiologic Aspects of Dark Eye Circles and Impact on Associated Quality of Life in Participants with Various Fitzpatrick Skin Types.","authors":"Lisa T Goberdhan, Katie Schneider, Giovanni Pellacani, Brian Biesman, Tsing Cheng, Elizabeth Makino","doi":"10.2147/CCID.S605666","DOIUrl":"https://doi.org/10.2147/CCID.S605666","url":null,"abstract":"<p><strong>Purpose: </strong>Dark eye circles (DECs) are a prevalent cosmetic concern for understanding the pathophysiological properties and etiology of DECs is crucial for effective treatment. This study assessed baseline DEC characteristics and associated quality of life (QOL) impacts in participants with varying DEC severities and Fitzpatrick Skin types (FSTs).</p><p><strong>Participants and methods: </strong>Adult with DECs across FSTs were enrolled into this observational study. Assessments were grouped as follows: clinical (investigator grading of DEC severity, DEC type, and puffiness), biophysical (spectrophotometry, corneometry, tewametry, and BTC-2000 elasticity/laxity measurements), imaging (standardized photography, 3D imaging, and dynamic optical coherence tomography [D-OCT]), and patient-reported outcomes (FACE-Q and participant questionnaires). Results were summarized descriptively by DEC severity and FST; statistical testing was performed for D-OCT comparisons across FST groups.</p><p><strong>Results: </strong>All 42 participants who completed the study had at least mild DEC severity in both lower and upper eyelids, with severe DEC incidence similar on the upper and lower eyelid. Most exhibited multiple DEC types (ie, pigmented, vascular, shadow effect) and mild eye area puffiness. Participants with mild DECs had the highest mean eyelid skin elasticity. Participants with moderate DECs showed transepidermal water loss (TEWL) measurements suggestive of high hydration and barrier function in the lower eyelid skin. Participants of all DEC severities were bothered by their upper and lower eyelids. Those with severe DEC reported on the FACE-Q more negative perceptions of their facial skin age and eyelid appearance and were less confident or positive about their facial appearance. DEC severity was highest in participants with FST V-VI. Pigmented and shadow effect DECs were observed more in FST III-IV and V-VI, whereas vascular DECs appeared most in FST I-II. Spectrophotometer results showed that the difference between control and lower eyelid skin was broadly similar across FST groups. D-OCT revealed that the FST V-VI group had significantly thinner vascular networks, but significantly higher epidermal thickness (P < 0.05) than the other FST groups. Participants with FST V-VI felt more positive perceptions about their skin age; however, types III-IV and V-VI were more bothered by their lower eyelids than types I-II.</p><p><strong>Conclusion: </strong>DECs are present on the upper and lower eyelids and participants are bothered by both areas regardless of severity. DEC characteristics varied according to severity and FST and influenced participant-based perception of eyelid appearance, facial age, and confidence.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"605666"},"PeriodicalIF":2.5,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13658432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploratory Identification of Multidimensional Treatment-Response Profiles in Androgenetic Alopecia Treated with Combined Scalp Microneedling and Topical Minoxidil Using Unsupervised Clustering.","authors":"Yibei Wu, Dihui Liu, Ying-Mei Lin, Hui Tang, Fujun Ouyang, Mingzhu Yao","doi":"10.2147/CCID.S636889","DOIUrl":"https://doi.org/10.2147/CCID.S636889","url":null,"abstract":"<p><strong>Background: </strong>Combination therapy with scalp microneedling and topical minoxidil is more effective than minoxidil alone in androgenetic alopecia (AGA), yet treatment responses vary considerably among patients and the multidimensional structure of this heterogeneity remains poorly characterized.</p><p><strong>Objective: </strong>To explore whether unsupervised clustering identifies distinct multidimensional treatment-response profiles during combination therapy and to describe their clinical and molecular characteristics as a hypothesis-generating basis for personalized management.</p><p><strong>Methods: </strong>In this prospective cohort study, 156 patients with AGA received standardized combination therapy (microneedling 1.0 mm depth, biweekly; 5% topical minoxidil, twice daily) for 24 weeks, with longitudinal trichoscopic, molecular and clinical assessments. K-means clustering was applied to ten standardized treatment-response (change-from-baseline) variables; the number of clusters was examined by silhouette, gap-statistic and bootstrap-stability analyses, and between-profile differences were tested with assumption-appropriate methods and reported with effect sizes.</p><p><strong>Results: </strong>Silhouette analysis indicated weak global cluster structure (k=2, 0.274; k=3, 0.168); a three-cluster solution was retained as an exploratory, clinically motivated grouping and labelled Robust (n=45, 28.8%), Moderate (n=56, 35.9%) and Limited (n=55, 35.3%) responders. Profiles differed across the response variables that defined them, including hair-density change (36.25±19.07 vs 17.76±10.93 hairs/cm² for Robust vs Limited; ε²=0.19) and Wnt10b transcript change (0.80±0.37 vs 0.27±0.19; ε²=0.34). Baseline clinical and molecular parameters, including LEF-1 and IGF-1, did not differ across profiles and did not predict profile membership.</p><p><strong>Conclusion: </strong>Unsupervised clustering identified three clinically interpretable treatment-response profiles accompanied by graded differences in Wnt/β-catenin-associated transcript changes. Because the profiles showed weak internal separation and could not be predicted from baseline characteristics, these hypothesis-generating findings suggest, rather than demonstrate, multidimensional structure in treatment response and require validation in independent, controlled cohorts before any clinical application.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"636889"},"PeriodicalIF":2.5,"publicationDate":"2026-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13656931/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149178755","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"LL-37-MRGPRX2-Mast Cell Signaling in Rosacea: Current Evidence and Directions for Human Studies.","authors":"Haoyang Yin, Yiping Lu","doi":"10.2147/CCID.S648503","DOIUrl":"https://doi.org/10.2147/CCID.S648503","url":null,"abstract":"<p><p>This critical narrative review examines evidence relevant to LL-37-Mas-related G protein-coupled receptor X2 (MRGPRX2)-mast-cell signaling in rosacea and considers the relevance of these findings to future human studies. Literature was identified through PubMed and Web of Science Core Collection searches, supplemented by examination of reference lists from relevant original studies and recent reviews. Human rosacea tissue studies show changes in mast-cell abundance or degranulation-associated staining and localize MRGPRX2 to lesional mast cells. Human mast-cell and receptor studies demonstrate LL-37-responsive MRGPRX2 calcium signaling and degranulation and show pharmacological inhibition of MRGPRX2-mediated responses. LL-37-induced mouse models support contributions of mast cells and murine Mas-related G protein-coupled receptor member B2 (MrgprB2), although human MRGPRX2 and murine MrgprB2 are pharmacologically distinct. Other LL-37-responsive pathways and downstream regulatory processes may also produce or modify similar mast-cell outcomes. Direct selective functional testing of MRGPRX2 in patients with rosacea remains lacking, and receptor-level functional findings and patient-level observations still arise largely from different study settings. Future human studies could therefore connect lesional MRGPRX2 status and selective receptor perturbation with proximal mast-cell responses and corresponding tissue or clinical changes within the same rosacea study setting. Under adequately designed study conditions, concordant findings may strengthen support for MRGPRX2 involvement, whereas partial, discordant, subgroup-restricted, or absent proximal responses may help refine its functional scope in human rosacea.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"648503"},"PeriodicalIF":2.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654256/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149166088","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Localized Bullous Pemphigoid of the Scalp and Face with Suspected Vulvar Involvement: A Case Report.","authors":"Xiqian Chen, Yixuan He, Qian Tang, Yangcan Luo, Siyu Chen, Changqiang Li, Zongjunlin Liu","doi":"10.2147/CCID.S639426","DOIUrl":"https://doi.org/10.2147/CCID.S639426","url":null,"abstract":"<p><strong>Background: </strong>Localized bullous pemphigoid (LBP) is a form of bullous pemphigoid (BP) confined to a limited anatomical area. Classification becomes less certain when clinically similar lesions occur at a distant site without site-specific immunopathologic confirmation. We report immunopathologically supported scalp/facial BP-spectrum disease with a temporally associated but unconfirmed vulvar eruption.</p><p><strong>Case presentation: </strong>A 51-year-old woman presented with a 3-month history of pruritic erythema and tense bullae on the scalp and face and a 1-month history of erythematous scaly plaques with hemorrhagic bullous lesions in the vulvar region. Scalp histopathology showed a subepidermal blister with eosinophil-rich inflammation, and direct immunofluorescence (DIF) of perilesional scalp skin showed linear IgG and C3 deposition along the basement membrane zone. Infectious studies of the vulvar eruption were negative. Anti-BP180/230 serology, indirect immunofluorescence, salt-split skin studies, and anti-type VII collagen antibody testing were unavailable. Vulvar biopsy and DIF were not performed; therefore, vulvar BP could not be confirmed. With systemic and topical corticosteroids plus adjunctive minocycline, no new bullae developed by day 5, and the lesions markedly improved within 2 weeks. Methylprednisolone was subsequently tapered from 40 mg/day to a maintenance dose of 4 mg/day; minocycline and topical corticosteroids were discontinued after sustained clinical improvement. At 6 months, the disease remained clinically controlled on methylprednisolone 4 mg/day, with no new bullae or clinically evident recurrence. No treatment-related adverse events were observed.</p><p><strong>Conclusion: </strong>The findings support localized BP/BP-spectrum disease of the scalp and face, while the vulvar eruption remains unconfirmed. The parallel treatment response is supportive but not diagnostic of vulvar BP. When feasible, lesions at sensitive sites should undergo site-specific biopsy and DIF. If biopsy is declined or impractical, pretreatment morphology should be carefully documented, diagnostic uncertainty should be acknowledged, and follow-up should assess for scarring and additional mucosal involvement.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"639426"},"PeriodicalIF":2.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13654268/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single‑Cell in silico Perturbation Uncovers a Ferroptosis Regulatory Network for Cigarette Smoke‑Induced Skin Aging and Identifies Dapivirine as a Candidate Agent.","authors":"Xiujuan Tan, Lin Tao, Binqi Liang, Hongtao Liu, Fengkun Zhou","doi":"10.2147/CCID.S640350","DOIUrl":"https://doi.org/10.2147/CCID.S640350","url":null,"abstract":"<p><strong>Objective: </strong>Cigarette smoke exposure induces cutaneous ferroptosis and accelerates skin aging, yet the core regulatory genes and targeted interventions remain unclear. This study aimed to identify key ferroptosis-driving genes underlying smoke-induced skin senescence, clarify their mechanisms, and screen candidate small molecules that reverse smoke-related skin damage.</p><p><strong>Methods: </strong>Young and aged human skin single-cell transcriptomic data from the GEO database were processed for quality control, dimensional reduction, clustering, and cell-type annotation. The scTenifoldNet toolkit performed bidirectional in silico perturbation (virtual knockout and overexpression) of seven smoke-upregulated ferroptosis driver genes, with GO and KEGG enrichment on perturbation-derived DEGs. Based on the smoke-exposed skin dataset GSE148221, the DrugReflector deep-learning model conducted high-throughput virtual screening, followed by Cb-Dock2 molecular docking to verify binding affinity of the top compound to the seven ferroptosis proteins.</p><p><strong>Results: </strong>Aging was the primary driver of global transcriptional remodeling, with aged skin showing prominent immune infiltration and elevated heterogeneity consistent with inflammaging. Bidirectional perturbation consistently identified KRT15 and CXCL14 as universal markers of disrupted ferroptosis signaling. Hub-gene dysregulation simultaneously triggered epidermal barrier dysfunction, cytoskeleton disorders, and chronic cutaneous inflammation. The anti-HIV agent dapivirine ranked first in AI screening and stably bound all seven targets, with particularly high affinity for CYBB, CHAC1, and HMOX1; no prior studies have reported its anti-skin-aging activity.</p><p><strong>Conclusion: </strong>ABCC1, ATG4D, CHAC1, CYBB, HILPDA, HMOX1, and PGD constitute the core ferroptosis genes mediating smoke-induced skin aging. Repurposed dapivirine targets and suppresses the cutaneous ferroptosis pathway, showing promise against smoke-triggered skin senescence. These findings offer novel mechanistic insights into extrinsic skin aging and support anti-aging drug repurposing.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"640350"},"PeriodicalIF":2.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13655668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injector Experience and Satisfaction with a Redesigned Syringe for Cohesive Polydensified Matrix Gels: A Non-Comparative Questionnaire-Based Study.","authors":"Elena Rossi, Nabil Fakih-Gomez, Sonja Sattler, Tatjana Pavicic, Ana Díez Gandía, Awat Hassan, Beate Maria Schneider, Chris Hutton, Juan Martín Zárate, Omar Haroon, Rolf Bartsch, Dalvi Humzah, Mimi Rosealie Borrelli","doi":"10.2147/CCID.S624583","DOIUrl":"https://doi.org/10.2147/CCID.S624583","url":null,"abstract":"<p><strong>Background: </strong>Clinician-reported evaluations of syringe injectability and handling during hyaluronic acid (HA) filler administration remain limited.</p><p><strong>Objective: </strong>To characterize experienced injectors' perceptions of the usability, handling, and safety-related features of a redesigned (Gen2) syringe for cohesive polydensified matrix (CPM) HA gels.</p><p><strong>Methods: </strong>In this retrospective, non-comparative analysis of a manufacturer-associated questionnaire evaluation, 17 experienced Key Opinion Leaders (KOLs), including nine manuscript authors, evaluated the Gen2 syringe following clinical use (n=12) or simulated use (n=5). The Gen2 syringe and CPM products were provided by the manufacturer. Participants completed a study-specific questionnaire reviewed for clarity, clinical relevance, and face validity and provided qualitative feedback regarding syringe ergonomics, handling, extrusion characteristics, injection control, and perceived safety-related features. No comparator syringe was evaluated. Questionnaire responses were summarized using descriptive statistics, with exact 95% confidence intervals calculated for selected proportions.</p><p><strong>Results: </strong>Injectors generally rated the evaluated syringe attributes favorably. The integrated Luer-lock was selected as a valuable design feature by 13/17 respondents (76.5%), followed by perceived lower extrusion force (11/17, 64.7%) and the concave thumb grip (9/17, 52.9%). Responses were predominantly favorable regarding perceived injection-volume accuracy and reduction in needle-detachment risk. Five of 17 respondents (29.4%) reported usability considerations, including scale orientation, syringe length, and resistance during rubber-bung removal.</p><p><strong>Conclusion: </strong>The redesigned syringe was rated favorably by this small, selected group of experienced injectors familiar with the legacy platform. These exploratory, perception-based findings should be interpreted in the context of the non-comparative design, sponsor-associated participant selection and use of a study-specific questionnaire developed for this evaluation. Comparative studies incorporating objective performance measures are warranted.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"624583"},"PeriodicalIF":2.5,"publicationDate":"2026-10-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13659065/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149179086","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Generalized Hailey-Hailey Disease Complicated by MRSA Infection: A Case Report of Management with Systemic Corticosteroids and Targeted Anti-Infective Therapy.","authors":"Changlin Sui, Jintao Chuan, Yanjie Wei, Xue Li, Lu Zhang","doi":"10.2147/CCID.S640024","DOIUrl":"https://doi.org/10.2147/CCID.S640024","url":null,"abstract":"<p><strong>Purpose: </strong>Generalized cutaneous involvement is an uncommon presentation of Hailey-Hailey disease (HHD), and secondary bacterial infection may further complicate its management. We report a case of generalized HHD complicated by methicillin-resistant <i>Staphylococcus aureus</i> (MRSA) infection.</p><p><strong>Patients and methods: </strong>A 38-year-old man presented with a five-year history of recurrent flexural eruptions and a generalized exacerbation during the preceding two weeks. The clinical presentation and histopathological findings of acantholysis with intraepidermal blister formation supported the diagnosis of HHD. Direct immunofluorescence was negative for IgG and C3. Genetic testing was not performed. Cultures of skin exudates from multiple lesions revealed growth of MRSA. Treatment included systemic corticosteroids, oral moxifloxacin, topical agents, and local skin care. Moxifloxacin was selected according to the antimicrobial susceptibility results.</p><p><strong>Results: </strong>After 12 days of treatment, the lesions showed marked improvement. The crusts detached, and some lesions resolved, leaving light-brown post-inflammatory hyperpigmentation.</p><p><strong>Conclusion: </strong>In this patient with generalized HHD, secondary MRSA infection was identified and treated as part of the combined regimen. Clinical improvement was observed during combined treatment; however, the relative contribution of each intervention and the durability of the response cannot be determined from a single case with short-term follow-up.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"640024"},"PeriodicalIF":2.5,"publicationDate":"2026-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13653515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global Mapping and Trends in Scabies Research Over Four Decades: A Bibliometric Analysis Supporting the WHO Elimination Agenda.","authors":"Rusmawardiana, Fifa Argentina, Raden Pamudji, M Izazi Hari Purwoko, Sarah Diba, Monica Trifitriana","doi":"10.2147/CCID.S600546","DOIUrl":"https://doi.org/10.2147/CCID.S600546","url":null,"abstract":"<p><strong>Background: </strong>Scabies is a neglected tropical disease with at least 200 million people affected worldwide at any one time and a disproportionate burden in resource-limited settings. Although World Health Organization (WHO) prioritization has increased attention to scabies control, the evolution, geographic distribution, collaboration patterns, and policy alignment of the global research landscape remain incompletely characterized. This study mapped publication trends, research inequities, and thematic shifts in relation to the WHO control agenda.</p><p><strong>Methods: </strong>A bibliometric analysis was conducted using Scopus and Web of Science records published from 1 January 1980 through 31 December 2025. Records were harmonized, screened, and deduplicated using R-bibliometrix version 5.1.1 and visualized using Biblioshiny version 5.1.1.</p><p><strong>Results: </strong>After cross-database screening and deduplication, 3696 publications were included. The annual growth rate was 3.24%, international collaboration was 13.84%, and mean citations were 13.98 per document. Australia (1170 publications), the United States (945), China (502), and the United Kingdom (455) were the leading contributors. Thematic patterns shifted from classical topical scabicides toward oral ivermectin, mass drug administration (MDA), standardized diagnosis, and implementation-oriented research, while resistance and crusted scabies emerged as prominent recent themes.</p><p><strong>Conclusion: </strong>Publication growth accelerated after 2017, temporally coinciding with WHO recognition of scabies as a neglected tropical disease; however, the descriptive design does not establish causality. Research output remains geographically concentrated, with no African or Latin American country represented among the 10 most productive countries. Broader international collaboration, research-capacity strengthening in highly endemic settings, and operational research on diagnosis, MDA, surveillance, and treatment effectiveness are priorities for the 2030 control agenda.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"600546"},"PeriodicalIF":2.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13651796/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149165460","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-Patient Split-Lesion Comparison of Non-Cultured Epidermal Cell Suspension versus a Mechanically Processed Follicular Preparation in Stable Segmental Vitiligo: A Case Report.","authors":"Huda ALQudah, Hanadi Qeyam, Yasmeen Alkatab, Wafaa Haddad","doi":"10.2147/CCID.S633767","DOIUrl":"https://doi.org/10.2147/CCID.S633767","url":null,"abstract":"<p><strong>Background: </strong>Cellular transplantation may be considered for carefully selected patients with stable, treatment-refractory vitiligo, particularly localized or segmental disease.</p><p><strong>Objective: </strong>To describe a single-patient intra-patient split-lesion comparison of autologous non-cultured epidermal cell suspension (NCES) and a mechanically processed follicular preparation.</p><p><strong>Case: </strong>A 20-year-old woman with long-standing stable segmental vitiligo involving the left popliteal fossa/posterior knee and adjacent lower-limb areas underwent split-lesion treatment after the same Er:YAG recipient-bed preparation. The upper region was assigned to a mechanically processed follicular preparation mixed with platelet-rich plasma (PRP), whereas the lower region received NCES. Allocation was made at the time of treatment without a prespecified anatomical preference; no formal randomization sequence or allocation-concealment method was documented. Both regions subsequently received 15 sessions of targeted 308-nm excimer light. At 12 months, non-instrumented visual estimation from serial clinical photographs suggested approximately 90% repigmentation in the NCES-treated region and approximately 20% in the follicular preparation-treated region. Photographs were not prospectively standardized, and no planimetry, validated outcome score, or blinded assessment was performed.</p><p><strong>Conclusion: </strong>In this patient, the NCES-treated region showed greater visually estimated repigmentation at 12 months. Informal treatment-region assignment without a documented randomization sequence, the PRP-containing follicular processing protocol, uncertain cellular content of the follicular preparation, and non-objective outcome assessment preclude comparative efficacy conclusions. This observation is hypothesis-generating.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"633767"},"PeriodicalIF":2.5,"publicationDate":"2026-10-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13651730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149164960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations Between Psoriasis and Endocrine Diagnoses in a Tertiary-Center Electronic Health Record Database: A Cross-Sectional Study.","authors":"Athira Sivadas, Dustin Taylor","doi":"10.2147/CCID.S638098","DOIUrl":"10.2147/CCID.S638098","url":null,"abstract":"<p><strong>Purpose: </strong>Psoriasis is associated with systemic comorbidities such as cardiovascular disease. The purpose of this study is to assess whether patients with psoriasis are more likely to also have endocrine disorders.</p><p><strong>Patients and methods: </strong>Using the Vanderbilt University Medical Center Synthetic Derivative, a de-identified database of more than 3.4 million patients, a cross-sectional study was conducted. PheWAS codes were used to identify patients with specific diagnoses.</p><p><strong>Results: </strong>The control cohort consisted of 3389683 patients (54.9% female) and the psoriasis cohort consisted of 10855 patients (55.5% female). The prevalence of several endocrine disorders was found to be higher in those with psoriasis than without, including Cushing's disease (0.322% vs 0.056%, age-adjusted odds ratio = 5.078, 95% CI = 3.650-7.066, p < 0.001), adrenal insufficiency (1.179% vs 0.225%, age-adjusted odds ratio = 4.388, 95% CI = 3.680-5.232, p < 0.001), hypothyroidism (10.567% vs 2.373%, age-adjusted odds ratio = 3.839, 95% CI = 3.607-4.085, p < 0.001), hyperthyroidism (1.704% vs 0.422%, age-adjusted odds ratio = 3.378, 95% CI = 2.919-3.910, p < 0.001), etc.</p><p><strong>Conclusion: </strong>These results suggest that patients with psoriasis may also be at risk for endocrine dysfunction. The consequences of systemic inflammation in patients with psoriasis may extend beyond metabolic disorders such as cardiovascular disease, and further investigation into the association between endocrine disorders and psoriasis may lead to improvements in the clinical management of the latter.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"638098"},"PeriodicalIF":2.5,"publicationDate":"2026-10-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13641111/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149104965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}