Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Cutaneous Granuloma Resulting from Mixed Infection with <i>Mycobacterium marinum</i> and <i>Candida metapsilosis</i>: A Case Report of Successful Treatment.","authors":"Jing Li, Yinggai Song, Xiao Liu, Jing Pan","doi":"10.2147/CCID.S520618","DOIUrl":"10.2147/CCID.S520618","url":null,"abstract":"<p><strong>Background: </strong><i>Mycobacterium marinum</i> and <i>Candida metapsilosis</i> are rare pathogens that cause chronic cutaneous and soft tissue infections. Although molecular technologies have improved their diagnosis, both diseases are challenging to treat. Here, we describe the first case of cutaneous granuloma caused by concurrent <i>M. marinum</i> and <i>C. metapsilosis</i> infections.</p><p><strong>Case presentation: </strong>A 67-year-old male patient presented with a one-year history of painful erythematous nodules on his left ring finger after a fish stabbing. He was apparently immunocompetent and received no immunosuppressive treatment. Histopathological examination revealed infectious granuloma. Positive cultures for mycobacteria and fungi, along with molecular testing, confirmed the mixed infection with <i>M. marinum</i> and <i>C. metapsilosis</i>. Considering his old age and hepatitis B core antibody, we initiated treatment with oral clarithromycin, topical sulfadiazine silver cream (SSC), and topical nifuratel nystatin gel (NNG). Owing to adverse events, the course of clarithromycin was limited to ten days. Nonetheless, a three-month regimen of continuous topical SSC and NNG led to the complete recovery of his lesions without recurrence.</p><p><strong>Conclusion: </strong>This is the first reported case of mixed infection with <i>M. marinum</i> and <i>C. metapsilosis</i>. The combination therapy with 10-day oral clarithromycin treatment and 3-month topical SSC and NNG successfully treated superficial infections caused by these two distinct pathogens. This case could offer a viable alternative for patients unable to endure prolonged systemic therapy. Further studies are required to verify its efficacy.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1213-1218"},"PeriodicalIF":1.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial Structures and Their Impact on Visual Perception of Beauty and Youthfulness: Parallelism.","authors":"Raul Banegas, Maria Cecilia Miksa, Ery Ayelen Ko","doi":"10.2147/CCID.S513424","DOIUrl":"10.2147/CCID.S513424","url":null,"abstract":"","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1207-1211"},"PeriodicalIF":1.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Successful Treatment of Cutaneous Foreign Body Granuloma with JAK Inhibitor Abrocitinib and Prednisone: A Case Report.","authors":"Jingqiu Fu, Wen Luo, Ping Wang, Weiwei Wu, Jiejie Lu","doi":"10.2147/CCID.S522469","DOIUrl":"10.2147/CCID.S522469","url":null,"abstract":"<p><strong>Background: </strong>Foreign body granuloma (FBG) formation is linked to chronic persistent cutaneous inflammation, representing a severe delayed complication characterized histologically by infiltration of multinucleated giant cells and aggregation of lymphocytes. In filler-induced FBG following cosmetic injections, implanted materials represent a key driver of sustained inflammatory responses. Achieving complete resolution remains challenging, with current therapeutic outcomes for FBG being suboptimal. Emerging evidence suggests that Janus kinase (JAK) inhibitors may constitute a promising therapeutic strategy for refractory granulomatous conditions.</p><p><strong>Objective: </strong>This case report describes the successful management of FBG using JAK inhibitors and synthesizes existing literature to evaluate the efficacy, safety, and potential mechanisms of abrocitinib in treating filler-induced cutaneous FBG.</p><p><strong>Methods: </strong>We present a case of post-filler FBG that presents with multiple smooth-surfaced, hemispherical lesions (3-5 mm in diameter) distributed across the entire facial region. The patient was treated with oral abrocitinib (100 mg daily) and prednisone (30 mg daily, tapered over 9 weeks). Clinical outcomes were assessed weekly for 13 weeks through serial clinical photography, dermoscopy, reflectance confocal microscopy, and multispectral imaging. Adverse events, including rash exacerbation, vomiting, dizziness, and fever, were systematically monitored. A comprehensive literature review was conducted to elucidate JAK inhibitors' therapeutic rationale in filler-associated FBG.</p><p><strong>Results: </strong>The patient achieved complete granuloma resolution within 13 weeks following failed corticosteroid monotherapy. No treatment-related adverse effects were observed during the one-month follow-up period, supporting the favorable safety profile of this therapeutic approach.</p><p><strong>Conclusion: </strong>This report provides preliminary evidence for JAK inhibitors' efficacy in managing refractory filler-induced FBG. Large-scale controlled trials are warranted to validate long-term safety and therapeutic benefits.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1199-1206"},"PeriodicalIF":1.9,"publicationDate":"2025-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12094822/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144119128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dupilumab for Atopic Dermatitis with Twenty-Nail Dystrophy: A Case Report.","authors":"Ji Li, Duo Zhang, Shuying Dong, Lili Zhu, Xiaodong Li, Yang Han","doi":"10.2147/CCID.S524384","DOIUrl":"10.2147/CCID.S524384","url":null,"abstract":"<p><p>Atopic dermatitis (AD) typically presents with cutaneous symptoms, but nail changes, particularly twenty-nail dystrophy (TND), are often overlooked. We report a case of a 40-year-old woman with a 3-year history of eczematous erythema and pruritus around the nails, accompanied by nail deformities. She had elevated serum IgE levels (2250 IU/mL) and dermatoscopic findings of thickened yellowish nails with splinter hemorrhages. Diagnosed with AD and TND, she received dupilumab after failing conventional treatments. Within 2 weeks, she experienced significant itch relief, and by 5 months, nearly complete nail recovery was observed, with serum IgE levels decreasing to 823 IU/mL. This case highlights the importance of recognizing nail involvement in AD, suggesting that periungual eczema and TND may represent a distinct phenotype. Dupilumab shows promise as an effective treatment for this condition, warranting further research.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1187-1190"},"PeriodicalIF":1.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12087789/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Improved Skin Lesion Segmentation in Dermoscopic Images Using Object Detection and Semantic Segmentation.","authors":"Takashi Nagaoka","doi":"10.2147/CCID.S518751","DOIUrl":"10.2147/CCID.S518751","url":null,"abstract":"<p><strong>Introduction: </strong>Lesion segmentation in dermoscopic images significantly enhances the diagnostic performance of AI-based classification models. However, conventional methods often require pixel-level annotations, which are resource-intensive and prone to errors caused by external artifacts, such as hair and skin markings.</p><p><strong>Methods: </strong>We propose a hybrid framework called SAM-enhanced YOLO, which integrates the Segment Anything Model (SAM) with You Only Look Once (YOLO) for precise pixel-level segmentation. This method combines YOLO's efficient lesion localization with SAM's advanced zero-shot segmentation capabilities. To further validate the framework, we compared it against traditional methods, including GrabCut and Otsu's thresholding, as well as SAM used without YOLO (SAM-only). For SAM-only, lesion segmentation was initialized at the image center to simulate a typical dermoscopic imaging setup.</p><p><strong>Results: </strong>SAM-enhanced YOLO demonstrated superior segmentation performance, achieving an Intersection over Union (IoU) of 0.738 and an F1-score (the harmonic mean of precision and recall) of 0.833, compared to 0.578 and 0.683 with SAM-only, respectively. This represents a 28% improvement in IoU and a 22% improvement in F1-score compared to SAM-only. The results were consistent across lesion shapes and contrast conditions, with SAM-enhanced YOLO exhibiting the lowest variability and highest robustness among the evaluated methods.</p><p><strong>Conclusion: </strong>By reducing the need for pixel-level annotations and outperforming both standalone SAM and traditional methods, SAM-enhanced YOLO provides a scalable and resource-efficient solution for dermoscopic lesion segmentation. This framework holds significant potential for improving diagnostic workflows in clinical and resource-limited settings.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1191-1198"},"PeriodicalIF":1.9,"publicationDate":"2025-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12089257/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144109506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immune Cells Phenotypes and Causal Relationship with Acne Vulgaris: Insights from Mendelian Randomization.","authors":"Jia Zeng, Yun Wang, Hongqin Lan","doi":"10.2147/CCID.S505042","DOIUrl":"10.2147/CCID.S505042","url":null,"abstract":"<p><strong>Object: </strong>We adopted a 2-sample bidirectional Mendelian randomization study to figure out whether circulating immune cells profiles causally impact acne vulgaris liability.</p><p><strong>Methods: </strong>Applying large-scale genome-wide association studies (GWAS) pooled data. We obtained the summary-level data for acne vulgaris (N=212,438) from the FinnGen Biobank. Using publicly available genetic data, we investigated the causal link between 731 immune cell profiles and DN risk. Included were four different types of immune systems: morphological parameters (MP), absolute cell (AC), relative cell (RC), and median fluorescence intensities (MFI). The results' robustness, heterogeneity, and horizontal pleiotropy were confirmed through extensive sensitivity analysis.</p><p><strong>Results: </strong>Our study identified causal associations between eight immune cells as potential mediators and acne vulgaris. Surprisingly, CD28 on CD39+ CD4+ T cell, CD39+ secreting CD4+ regulatory T cell and secreting CD4+ regulatory T cell were identified as the protective immunophenotype (OR=0.902, 0.944, 0.967, 95% CI 0.847-0.961, 0.906-0.983, 0.944-0.991). Moreover, CD24+ CD27+AC, CD24 on IgD+ CD38br mediated 5.723% and 6.844% of the decreased risk for acne vulgaris. Furthermore, FSC-A monocytes were found to mediate the increased risk of acne vulgaris, contributing 7.384% to this mediation. CD20-CD38-AC cells were identified to be associated with the 17.04% increased risk of acne vulgaris.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1177-1185"},"PeriodicalIF":1.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12086709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144101469","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bidirectional Two-Sample Mendelian Randomization Study of Genetic Causality Between Vitamin D Levels and Pemphigus.","authors":"Yanchun Wang, Shiping Cheng, Huafa Que","doi":"10.2147/CCID.S523136","DOIUrl":"https://doi.org/10.2147/CCID.S523136","url":null,"abstract":"<p><strong>Background: </strong>Pemphigus, a B-cell-mediated autoimmune disease, has been hypothesized to involve vitamin D due to its immunomodulatory effects on B-cell activity. However, observational studies on this association remain inconclusive due to confounding factors. This study used genome-wide association study (GWAS) data for bidirectional two-sample Mendelian randomization (MR) analysis to clarify causality.</p><p><strong>Materials and methods: </strong>Genetic instruments for serum vitamin D levels (61 SNPs) and pemphigus (3 SNPs) were analyzed via inverse variance weighting (IVW), weighted median, and MR-Egger regression. Forward MR analysis revealed no causal effect of vitamin Don pemphigus risk [IVW OR=0.835 (95% CI:0.318-2.189), P=0.623], consistent across sensitivity analyses. Conversely, reverse MR showed pemphigus did not influence vitamin D levels [IVW OR=1.000 (95% CI:0.993-1.006), P=0.867]. Heterogeneity (Cochran Q test) and pleiotropy (MR-Egger intercept) tests confirmed robustness of results.</p><p><strong>Results: </strong>Our findings challenge the presumed causal link between vitamin D and pemphigus, suggesting observed associations may arise from confounding factors. This underscores the need for mechanistic studies to explore alternative pathways in pemphigus pathogenesis.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1167-1176"},"PeriodicalIF":1.9,"publicationDate":"2025-05-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12077410/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Rare Case Of Pigmented Mammary Paget Disease.","authors":"En Hyung Kim, Wonnam Kim, Ji Yeoun Lee","doi":"10.2147/CCID.S515553","DOIUrl":"https://doi.org/10.2147/CCID.S515553","url":null,"abstract":"<p><p>Pigmented mammary Paget disease is a rare clinicopathologic variant of mammary Paget disease, which can mimic melanoma. We report a patient who visited the dermatology department complaining of asymptomatic brown-black plaque localized on the left nipple that had been present for 1 year. Histopathology showed large neoplastic epithelial cells with enlarged nuclei and pale cytoplasm, some harboring granular brown melanin pigment. Immunohistochemical studies showed that the intraepidermal pagetoid cells were positive for CK7, ER, and Her2, while mostly lacking immunoreactivity for CK5, SOX10, and HMB45, supporting a diagnosis of MPD. Therefore, physicians should be aware of this rare entity when diagnosing patients with pigmented lesions on the breast area.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1163-1166"},"PeriodicalIF":1.9,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12075387/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076536","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"<i>Lactobacillus brevis</i>-Derived Exosomes Enhance Skin Barrier Integrity by Upregulating Key Barrier-Related Proteins.","authors":"Yong-Han Cho, Ji-Woo Kim, Nari Kim, Hee-Sik Kim, Jun-Hwan Jang, Jun-Tae Bae, Wanil Kim","doi":"10.2147/CCID.S512793","DOIUrl":"https://doi.org/10.2147/CCID.S512793","url":null,"abstract":"<p><strong>Introduction: </strong>The human skin, comprising the epidermis, dermis, and subcutaneous fat layers, serves as a critical barrier against external stimuli. The integrity of this barrier function is essential for preventing skin damage and diseases. When compromised, it can lead to various dermatological issues.</p><p><strong>Methods: </strong>This study investigated the efficacy of <i>Lactobacillus brevis</i> J2K55-derived exosomes (LBDEs) on enhancing skin barrier function. High-purity LBDEs were produced and characterized using nanoparticle tracking analysis and Cryo-TEM, concentrated to 1.52×10⁸ particles/mL with sizes ranging from 50 to 200 nm. The LBDEs were then applied to human keratinocytes, HaCaT cells, and a live human skin model to analyze the expression of genes significant to skin barrier function.</p><p><strong>Results: </strong>In vitro experiments demonstrated that 2.5% LBDEs increased Filaggrin mRNA expression by 301.80% compared to the control. In an ex vivo skin damage model induced by physical stimulation and UVB (Ultraviolet B) irradiation, 1% LBDEs treatment significantly upregulated the expression of key barrier-related proteins, including Aquaporin-3 (180.8%), Claudin-1 (205.4%), Filaggrin (309.9%), Loricrin (365.2%), and Serine palmitoyltransferase (191.3%), in comparison to the friction and UVB-induced control group.</p><p><strong>Conclusion: </strong>These results suggest that LBDEs have potential in enhancing skin barrier function, as evidenced by increased expression of crucial barrier-related proteins in both in vitro and ex vivo models.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1151-1162"},"PeriodicalIF":1.9,"publicationDate":"2025-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068317/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143977923","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does Bilirubin Have a Causal Relationship With Vitiligo? A Mendelian Randomization Study and Bioinformatics Analysis.","authors":"Danfeng Xu, Yinmeng Yin, Yan Teng, Youming Huang, Yong Yu, Xiaohua Tao, Yibin Fan, Xiaoxia Ding","doi":"10.2147/CCID.S522604","DOIUrl":"https://doi.org/10.2147/CCID.S522604","url":null,"abstract":"<p><strong>Background: </strong>Vitiligo is a complex acquired pigmentary disorder whose pathogenesis is closely linked to oxidative stress. Although bilirubin, a potent endogenous antioxidant, has been implicated in various dermatological conditions, its specific role in vitiligo remains poorly defined. This study aims to investigate the causal associations between bilirubin and vitiligo using Mendelian randomization (MR) analysis, complemented by bioinformatics validation to unravel the underlying molecular mechanisms.</p><p><strong>Methods: </strong>Genome-wide association study (GWAS) data pertaining to vitiligo and bilirubin were obtained, followed by the execution of a bidirectional MR analysis. Additionally, we performed a bioinformatics analysis using microarray datasets to identify differentially expressed genes (DEGs) in relation to bilirubin in patients with vitiligo. Pathway enrichment and gene interaction networks were constructed to explore the molecular mechanisms linking bilirubin to vitiligo pathogenesis.</p><p><strong>Results: </strong>Forward MR analysis demonstrated a significant causal relationship between elevated levels of total bilirubin (P=0.038) and direct bilirubin (P=0.013) with reduced risk of vitiligo. In contrast, reverse MR analysis showed no significant causal effect of vitiligo on bilirubin (P>0.05). Bioinformatics analyses identified 136 DEGs in generalized vitiligo, 32 in segmental vitiligo, and 9 in non-segmental vitiligo. Enrichment analysis highlighted significant associations with oxidative stress-related pathways, including PI3K-Akt and JAK-STAT signaling, which are critical in melanocyte survival and immune regulation.</p><p><strong>Conclusion: </strong>This study provides robust evidence supporting a causal relationship between elevated bilirubin and a reduced risk of vitiligo, driven by its antioxidant properties. The identified DEGs and enriched pathways further elucidate the molecular mechanisms of bilirubin in the pathogenesis of vitiligo through oxidative stress, and may provide insights for future therapeutic strategies.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1107-1119"},"PeriodicalIF":1.9,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12065460/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143969339","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}