Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Personality Traits and Motivations of Chinese Adults Seeking Cosmetic Botulinum Toxin Injection.","authors":"Chen Wang, Huan Qian, Mengwen Zhang, Chenggang Yi","doi":"10.2147/CCID.S511665","DOIUrl":"10.2147/CCID.S511665","url":null,"abstract":"<p><strong>Background: </strong>Cosmetic Botulinum toxin (BoTx) injection has become a popular trend. There is evidence that beauty seekers improve their self-esteem and psychological state through BoTx injection. However, the personality traits in Chinese patients with cosmetic injections have not yet been investigated.</p><p><strong>Objective: </strong>This study aimed to investigate the motivations and personality profiles of patients seeking cosmetic BoTx injections using the Eysenck Personality Questionnaire (EPQ).</p><p><strong>Methods: </strong>The present study used a cross-sectional design, and was conducted with a sample of 195 randomly selected patients seeking BoTx treatment. All participants completed the EPQ. We also provide options listed to explore patients' motivations for seeking treatment. The demographic information was collected and analysed.</p><p><strong>Results: </strong>A total of 195 patients were enrolled, with a mean age of 33.09 ± 8.70 years. Of the 195 participants, 177 (90.77%) were women and 18 (9.23%) were men. The mean age of the participants was 33.09 ± 8.70 years, and the majority (74.36%) had a bachelor's degree or higher. We investigated three injection options, including lower facial contour treatment, anti-aging wrinkle injection, and body slimming injection. The EPQ of all participants showed higher E and N scores, but lower P and L scores compared to the norms. The participants age below 30 of lower facial contour injection had significantly higher P scores (p=0.048) and N scores (p=0.004), while N scores of anti-aging wrinkle treatments were significantly lower (p=0.013).</p><p><strong>Conclusion: </strong>Our study was the first using EPQ to depict the personality traits of Chinese adults seeking cosmetic BoTx injection. Initially, we questioned the purpose of aesthetic treatment in the Chinese population, which were more affected by psychological factors. Identifying personality traits before injection will assist physicians in providing a psychologically matched treatment plan while improving treatment satisfaction. These findings suggest that understanding patients' personality traits can help physicians better predict treatment expectations and preferences. For example, patients with high neuroticism scores may be more anxious about treatment outcomes, so physicians can provide more detailed pre-treatment counseling and postoperative follow-up, which is crucial for improving treatment satisfaction and reducing potential medical disputes.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"709-719"},"PeriodicalIF":1.9,"publicationDate":"2025-03-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11954393/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histopathological Subtypes and Clinical Presentation of Seborrheic Keratosis: A 15-Year Retrospective Analysis of 1,169 Cases in Hainan, China.","authors":"Wen Luo, Yujia Liang, Xianxu Yang, Weiwei Wu, Jiejie Lu","doi":"10.2147/CCID.S517318","DOIUrl":"10.2147/CCID.S517318","url":null,"abstract":"<p><strong>Background: </strong>Seborrheic keratosis (SK), the most common benign epithelial tumor, frequently presents with cosmetic concerns despite its benign nature. The clinicopathological features of SK may demonstrate notable geographical variability. Diagnosis remains challenging due to varied clinical presentations.</p><p><strong>Objective: </strong>This study aimed to investigate the clinicopathological characteristics of SK through a comprehensive analysis of a large patient cohort.</p><p><strong>Methods: </strong>We conducted a retrospective analysis of clinical and pathological data from 1,169 patients diagnosed with SK between 1 January 2009 and 31 December 2023. Histopathological subtypes were categorized, and a descriptive analysis of demographic and clinical characteristics was performed.</p><p><strong>Results: </strong>A total of 1,169 SK specimens were identified. The most frequent histopathological subtype was the acanthotic type (79.86%, 960 cases), followed by melanoacanthoma (7.98%, 92 cases), adenoid (5.32%, 64 cases), hyperkeratotic (4.90%, 59 cases), irritated (1.74%, 21 cases), and clonal (0.004%, 6 cases). The male-to-female ratio was 1.3:1, with a higher prevalence in men. SK most commonly affected the head, face, and neck, which accounted for 54.58% of cases (656/1,169), followed by the trunk (28.87%, 347 cases) and extremities (11.48%, 138 cases). The perineal area accounted for 4.48% (54 cases), while mucosal and plantar lesions were rare. The acanthotic subtype predominated across all anatomical sites, including mucosal and plantar regions. The age group most frequently diagnosed with SK was 40-59 years, with the acanthotic, melanoacanthoma, and adenoid types being particularly prevalent in this cohort. The clinical-pathological diagnostic concordance rate was 55.69%, indicating a relatively high rate of diagnostic discrepancy based on visual examination alone.</p><p><strong>Conclusion: </strong>Our study confirms the acanthotic subtype as the most common histological type of SK, predominantly observed in patients aged 40-59 years. The head, face, and neck emerged as the most frequently involved sites. Ultraviolet radiation may play a significant role in SK pathogenesis.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"721-727"},"PeriodicalIF":1.9,"publicationDate":"2025-03-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11952144/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143751432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report and Literature Review on Skin Toxicity Induced by PD-1 Inhibitor in a Penile Cancer with Massive Ulceration of Chemoradiotherapy-Resistant and Successful Treatment by Immunotherapy.","authors":"Yanyan Zhu, Daxia Cai, Jiangle Jiang, Jianfei Tu, Zhifeng Tian, Xiayan Zhang, Songmei Luo, Yonghui Wang","doi":"10.2147/CCID.S505045","DOIUrl":"10.2147/CCID.S505045","url":null,"abstract":"<p><p>Penile cancer is a rare malignant tumor with a poor prognosis in advanced stages. Immune checkpoint inhibitors (ICIs) have demonstrated promising efficacy in patients with advanced penile cancer, but it can also induce immune-related adverse events (irAEs). This article reports a patient who achieved almost a complete response to the PD-1 inhibitor sintilimab as third-line treatment for advanced penile squamous cell cancer with massive ulceration of chemoradiotherapy-resistant, and successful treatment by immunotherapy. One year into maintenance therapy with sintilimab, skin toxicity in the form or grade-2 skin rashes and grade-3 pruritus occurred. Sintilimab was permanently discontinued. The skin toxicity was effectively controlled by oral prednisone at a daily dosage of 15 mg. At the last follow-up of 16 months after sintilimab discontinuation, the patient remained in partial response, with total progression-free survival exceeding 30 months. We also conducted a comprehensive literature search, and summarized skin toxicity of ICIs administration. These articles suggested that immune-related skin toxicity may be indicative of good treatment response.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"699-707"},"PeriodicalIF":1.9,"publicationDate":"2025-03-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11947025/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between Poor Lifestyle Habits and Cutaneous Melanoma Risk: A Mendelian Randomization Study.","authors":"Xiaohui Liu, Wenkang Luan, Shujun Fan, Tengfei Liu","doi":"10.2147/CCID.S506547","DOIUrl":"10.2147/CCID.S506547","url":null,"abstract":"<p><strong>Background: </strong>There is still no consensus on the risk factors of cutaneous melanoma, and the causal relationship between poor lifestyle habits (including undersleeping, smoking, alcohol consumption and sedentary behaviour) and cutaneous melanoma remains uncertain.</p><p><strong>Methods: </strong>We investigated the causal effect of poor lifestyle habits on cutaneous melanoma through the Two-sample Mendelian randomization (MR). MR analysis was performed by using the genome-wide association studies (GWAS) statistics. Single-nucleotide polymorphisms (SNPs) robustly associated with undersleeping, smoking, alcohol consumption and sedentary behaviour were used as instrumental variables, we performed five MR approaches, including inverse variance weighted (IVW), weighted median, simple mode, MR-Egger and weighted mode.</p><p><strong>Results: </strong>The causal relationship between undersleeping and cutaneous melanoma was discovered in IVW (OR = 1.018, 95% CI = 1.002-1.033, P = 0.025). However, the causal association between smoking, alcohol consumption, sedentary behaviour and cutaneous melanoma have not been found in all MR approaches.</p><p><strong>Conclusion: </strong>The MR analysis indicated that undersleeping is causally associated with the risk of cutaneous melanoma.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"687-697"},"PeriodicalIF":1.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11934895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708921","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Targets Related to Skin Aging: Based on eQTL and GWAS Datasets.","authors":"Hanping Shi, Xianwei Cao","doi":"10.2147/CCID.S508946","DOIUrl":"10.2147/CCID.S508946","url":null,"abstract":"<p><strong>Background: </strong>The aging of skin has important impact on various systems, and certain skin aging (SG) markers can not only help with early diagnosis, but also provide new ideas for pathophysiological research and treatment strategies.</p><p><strong>Objective: </strong>To identify target genes related to SG through bioinformatics technology and provide ideas for skin anti-aging.</p><p><strong>Methods: </strong>Differential expression genes (DEGs) related to SG were screened through transcriptome information from GEO datasets (GSE85358 and GSE670988). Based on eQTL and GWAS datasets, Mendelian Randomization (MR) analysis was applied to identify associations between gene expression and SG. Then, aging skin related important genes (AS-IGs) were obtained based on above two steps, and functional and pathway analyses were performed to explore the potential mechanisms AS-IGs in SG. Finally, the CIBERSORT evaluation was used to assess the infiltration of immune cells related to SG.</p><p><strong>Results: </strong>Seven AS-IGs were selected through intersection from 612 DEGs and 399 eQTL genes. Then, enrichment analysis results showed there were 60 GO terms may involved in the process of SG, like fatty-acyl-CoA metabolic process, while KEGG enrichment pathways identified mainly involved in mechanisms related to fatty acid metabolism, energy generation, and inflammation regulation. The CIBERSORT evaluation showed that NK cells resting were the main infiltrating cells.</p><p><strong>Conclusion: </strong>AS-IGs may play important roles in the process of SG in the body. These molecules involve multiple systems and mechanisms in the body, such as immune function, metabolic function, and neuroendocrine function.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"677-686"},"PeriodicalIF":1.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11937646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143718260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dermoscopic Features of Erosive Pustular Dermatosis of the Scalp: A Comparative Multicentric Retrospective Study in Bald and Hairy Patients.","authors":"Noemi Plozner, Enrico Zelin, Iris Zalaudek, Aimilios Lallas, Bianca Maria Piraccini, Michela Starace, Enzo Errichetti","doi":"10.2147/CCID.S514416","DOIUrl":"10.2147/CCID.S514416","url":null,"abstract":"<p><strong>Background: </strong>Erosive pustular dermatosis of the scalp (EPDS) is a rare inflammatory disorder primarily affecting elderly individuals with bald or hairy scalps. It is often misdiagnosed due to clinical overlap with other scalp conditions. Dermoscopy is an invaluable diagnostic tool for hair and scalp disorders, but its utility in EPDS remains underexplored. This study aims to identify dermoscopic features of EPDS and compare them with differential diagnoses to improve non-invasive recognition.</p><p><strong>Materials and methods: </strong>A retrospective multicentric study was conducted across three Italian dermatological centers. Two cohorts, bald and hairy patients with histologically confirmed EPDS, were compared with controls diagnosed with conditions mimicking EPDS. Dermoscopic images at 10× magnification were analyzed by two independent evaluators using standardized criteria. Comparative analyses of dermoscopic features and interobserver agreement were performed, with statistical significance set at p<0.01.</p><p><strong>Results: </strong>A total of 116 patients [53 bald patients (28 with EPDS and 25 controls) and 63 hairy patients (32 with EPDS and 31 controls)] were included in the study. Among EPDS bald patients, linear-curved vessels (unspecific distribution) (78.6%), orange structureless areas (diffuse) (46.4%), and yellow scales/crusts (focal) were the main findings, whereas focal yellow scales/crusts (84.4%) and the \"peripheral horizontal hair\" sign (84.4%) turned out to be the most common features in EPDS hairy patients. Comparative analysis revealed linear-curved vessels (p<0.001), orange structureless areas (diffuse) (p<0.001) and non-follicular pustules (p=0.005) to be distinctive features of EPDS in bald patients, while yellow scales/crusts (focal), non-follicular pustules and \"peripheral horizontal hair\" sign (horizontally arranged hair whose proximal part of the shaft is seen through a thinned epidermis at the edge of alopecic areas) were related (p<0.001) to EPDS in hairy patients. Interobserver agreement was excellent (Kappa=0.81-0.83).</p><p><strong>Conclusion: </strong>Dermoscopy provides valuable diagnostic clues for EPDS, distinguishing it from other scalp disorders.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"669-676"},"PeriodicalIF":1.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932932/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143708893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Abrocitinib Treatment for Localized Type of Generalized Pustular Psoriasis: A Case Report.","authors":"Zhili Yang, Jiejie Lu, Zhen Li","doi":"10.2147/CCID.S517299","DOIUrl":"10.2147/CCID.S517299","url":null,"abstract":"<p><p>Generalized Pustular Psoriasis (GPP) is a recurrent dermatological condition characterized by widespread erythematous plaques, scaling, and sterile pustules. Notably, in a subset of patients, these lesions manifest exclusively in localized areas. We report a case where abrocitinib was used to treat the localized type of GPP, achieving relatively good clinical efficacy and without obvious side effects. To date, there are no published reports on the use of abrocitinib for GPP treatment, either domestically or internationally, making this case a valuable reference for clinicians and researchers.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"663-668"},"PeriodicalIF":1.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11932029/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of Biophysical Parameters of the Skin of Patients With Atopic Dermatitis After Application of an Ointment Containing 30% Cannabidiol and 5% Cannabigerol.","authors":"Dawid Daniel Burczyk, Dominika Wcisło-Dziadecka, Paweł Olczyk, Elżbieta Chełmecka, Wiktoria Klaudia Burczyk","doi":"10.2147/CCID.S472746","DOIUrl":"10.2147/CCID.S472746","url":null,"abstract":"<p><strong>Introduction: </strong>A growing number of publications are devoted to topical cannabinoid therapies in present-day cosmetology, as they appear to be safe and effective treatment modalities aimed at improving the comfort and quality of life of patients with atopic dermatitis (AD). A thorough patient interview, physical examination, clinical picture, and aetiopathogenesis of AD allow for a correct diagnosis and enable the choice of the least invasive pharmacological treatment.</p><p><strong>Purpose: </strong>In our medical experiment, we found a correlation between the findings of studies by other authors and the validation of our hypothesis that topical cannabinoid therapy is effective in the prevention and management of AD flares. A thorough analysis of the obtained results provided insights into the extent to which the applied ointment influenced the improvement of the skin's biophysical parameters (hydration, lipid content, transepidermal water loss, and erythema).</p><p><strong>Patients and methods: </strong>This medical experimental study was conducted from May to July 2022 and included a group of nine patients (five men and four women) aged 20- to 67-years-old were diagnosed with AD. The study involved transdermal delivery of an ointment compounded with cholesterol ointment, 30% cannabidiol (CBD), 5% cannabigerol (CBG), and hemp seed oil, and assessment of biophysical skin parameters, including corneometry (skin hydration), TEWL, sebumetry, and pH (acidity).</p><p><strong>Results: </strong>A preliminary analysis of our pilot study points to the potential of employing ointments and creams containing 30% CBD and 5% CBG as alternatives to conventional auxiliary therapies during both flare-ups and remission. The results we achieved included improved skin hydration, sebum level, and TEWL as well as reduced erythema in the studied areas (forearms).</p><p><strong>Conclusion: </strong>Our results demonstrate that topical cannabinoid therapy is effective in reducing itching and improving the quality of life of patients with AD, leading to symptom remission in some cases.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"649-662"},"PeriodicalIF":1.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930258/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Treatment and Evaluation of Dandruff and Scalp Erythema with Fermented <i>Salix purpurea</i> Bark Extract.","authors":"Oliwia Kalinowska, Julia Maślana, Andrea Gilreath","doi":"10.2147/CCID.S503915","DOIUrl":"10.2147/CCID.S503915","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to gain knowledge of scalp and hair tolerance and efficacy of two investigational shampoo formulations with different concentrations of fermented <i>Salix purpurea</i> (purple willow) bark extract tested on dandruff sufferers.</p><p><strong>Methods: </strong>This non-invasive study included a trichologist assessment of tolerance, clinical evaluation of efficacy, and photo documentation by macrophotography with Aramo ASW 300F. Statistical analysis was conducted using paired sample t-tests or Wilcoxon signed-rank tests to assess within-group changes, and unpaired t-tests or Mann-Whitney <i>U</i>-tests to compare results between groups. A significance level of p <0.05 was used to determine the efficacy of the treatments. A split-panel of 21 participants with varying scalp conditions, including visible dandruff, used the shampoos (Salixin Shampoo 2% or Salixin Shampoo 4%) for 56 consecutive days. Regular assessments were performed under trichological and dermatological supervision, including evaluation of scalp appearance, itching, redness, dandruff visibility, and subject-reported side effects.</p><p><strong>Results: </strong>Results indicated that both formulations were well tolerated. Evaluations demonstrated a reduction in dandruff symptoms for both shampoos, with Salixin Shampoo 4% showing a more pronounced effect, although not statistically significant.</p><p><strong>Conclusion: </strong>These findings suggest that fermented <i>Salix purpurea</i> bark extract is effective in reducing dandruff and improving scalp condition, with higher concentrations offering enhanced efficacy.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"639-648"},"PeriodicalIF":1.9,"publicationDate":"2025-03-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11930920/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143699783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association Between a Body Shape Index and Body Roundness Index with Prevalence of Psoriasis: A Cross-Sectional Population-Based Study.","authors":"Qianjie Wu, Ling Yu, Qianqian Yu","doi":"10.2147/CCID.S512864","DOIUrl":"10.2147/CCID.S512864","url":null,"abstract":"<p><strong>Background: </strong>Previous studies have suggested an intimate association between obesity and psoriasis. This study aimed to evaluate and compare the association between traditional and novel obesity biomarkers - waist circumference (WC), body mass index (BMI), a body shape index (ABSI), and body roundness index (BRI) - and the risk of psoriasis.</p><p><strong>Methods: </strong>This cross-sectional study utilized data from the 2003-2006 and 2011-2014 National Health and Nutrition Examination Survey. The association between obesity biomarkers and psoriasis risk was evaluated using multivariate logistic regression and smoothed curve fitting. The diagnostic performance of various biomarkers for identifying psoriasis were calculated and compared using receiver-operating characteristic curves.</p><p><strong>Results: </strong>Overall, 12,406 participants without psoriasis, 287 with mild psoriasis, and 68 with moderate-severe psoriasis, were included. Compared to the lowest quartile of WC, BMI, and BRI, higher quartiles were associated with significantly higher risks of psoriasis (all P for trend < 0.05). The area under the curve for identifying psoriasis was highest for BRI, which was comparable to WC (0.581 vs 0.575, P=0.34) but significantly higher than that of ABSI (0.581 vs 0.546, P=0.04) and BMI (0.581 vs 0.569, P=0.007). The association between BRI and psoriasis risk was not influenced by participant's age, sex, smoking status, physical activity, hypertension and diabetes status.</p><p><strong>Conclusion: </strong>BRI is positively associated with risk of psoriasis and outperforms BMI and ABSI in identifying psoriasis. Given the cross-sectional design of this study, future research employing prospectively designed longitudinal studies is necessary to validate our findings.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"627-638"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691481","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}