Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Double Chin Correction with Combination of High Intensity Focused Ultrasound and Hyaluronic Acid: A 24-Week Case Report.","authors":"Aira Fujimaki, Akiko Imaizumi","doi":"10.2147/CCID.S599307","DOIUrl":"10.2147/CCID.S599307","url":null,"abstract":"<p><p>Submental fullness, commonly referred to as a double chin, is a frequent aesthetic concern influenced by subcutaneous fat accumulation and underlying skeletal structure. High-intensity focused ultrasound (HIFU) and hyaluronic acid (HA) filler injection have each been used as minimally invasive treatment options; however, reports on their combined use remain limited. We report two Asian female patients with mild to moderate submental fullness who were treated with a sequential combination of linear HIFU and HA filler injection in routine clinical practice. One patient underwent HIFU followed by HA injection, whereas the other received HA injection prior to HIFU treatment. Both patients demonstrated improvement in submental contour, cervicomental angle, and chin projection during follow-up, with results maintained at 24 weeks. Patient satisfaction was high, treatment-related discomfort was minimal, and no immediate or delayed adverse events were observed. Although limited by the small number of cases, these observations suggest that a combined approach using HIFU and HA filler may represent a well-tolerated, minimally invasive option for selected patients with submental fullness.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"599307"},"PeriodicalIF":2.2,"publicationDate":"2026-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13086036/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147721815","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyaluronic Acid Filler CPM-V ± Lidocaine for Chin Augmentation: A Randomized, Multicenter, Open-Label Post-Market Follow-Up Study.","authors":"Tatjana Pavicic, Martina Kerscher, Sonja Sattler, Welf Prager, Ulrich Kühne, Ernst Magnus Noah, Eva Kristina Bee, Rodrigo da Mota, Michael Sebastian, Peter Arne Gerber, YingJu Tseng, Christian Carreon, Tanja C Fischer","doi":"10.2147/CCID.S571260","DOIUrl":"https://doi.org/10.2147/CCID.S571260","url":null,"abstract":"<p><strong>Background: </strong>This post-marketing study evaluated the clinical performance and safety of Belotero^® Volume (CPM-V) and Belotero^® Volume Lidocaine (CPM-V+) for chin augmentation in a real-world setting.</p><p><strong>Methods: </strong>This prospective, open-label, randomized study was carried out in Germany. Participants seeking chin augmentation received treatment with CPM-V (n=58) or CPM-V+ (n=63), with an optional touch-up 4 weeks after. The primary effectiveness endpoint was change in chin volume (mL) from baseline to 12 weeks after the last injection (Week 12 or Week 16 for participants with touch-up treatment), measured by validated 3D facial imaging. Secondary endpoints included the change from baseline in the glabella-subnasale-pogonion (G-Sn-Pg) angle (°), the investigator- and participant-assessed Global Aesthetic Improvement Scales (iGAIS/pGAIS) scores, the investigator-assessed Merz Aesthetics Scale (MAS) for chin projection, and participant satisfaction with treatment evaluated by FACE-Q - Satisfaction with Chin. Safety was assessed through adverse event reporting.</p><p><strong>Results: </strong>From baseline to Week 12/16, chin volume increased by a mean (standard deviation [SD]) of 2.5 (0.2) mL (95% confidence interval 2.1, 2.9; p<0.0001) and mean (SD) G-Sn-Pg angle increased by 1.9° (1.7°). At Week 12/16, almost all participants experienced ≥1 point improvements from baseline in MAS for chin projection (91.4%), iGAIS (100%), and pGAIS (99.1%). The mean (SD) Rasch-transformed score FACE-Q - Satisfaction with Chin was 66.6 (18.7) at Week 12/16. Thirty participants (24.8%) reported treatment-related adverse events; incidence was similar between treatment groups and the majority of events were mild to moderate in intensity and transient in nature.</p><p><strong>Conclusion: </strong>CPM-V and CPM-V+ were effective for chin augmentation in aesthetic clinical practice. No new safety concerns were identified.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"571260"},"PeriodicalIF":2.2,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13075509/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical Applications of Punch-Based Techniques in Dermatologic Surgery.","authors":"Mingtu Du, Haiyan Qin, Lianbo Zhang","doi":"10.2147/CCID.S588240","DOIUrl":"https://doi.org/10.2147/CCID.S588240","url":null,"abstract":"<p><p>Punch-based techniques are widely used minimally invasive surgical procedures in dermatologic surgery. Beyond diagnostic use, punch-based procedures are increasingly applied therapeutically across multiple conditions. This review summarizes the current therapeutic applications of punch-based techniques and discusses the strengths and limitations of existing evidence. Current literature supports the use of follicular unit extraction (FUE) for androgenetic alopecia, with generally predictable and reproducible outcomes. In contrast, applications of punch-based techniques for scar improvement, vitiligo repigmentation, chronic wound repair, pilonidal sinus management, and keloid volume reduction are more heterogeneous, and their efficacy often depends on disease stability, combination treatment strategies, and operator experience. Punch elevation, as an adjunctive technique, may improve outcomes in selected atrophic acne scars. In benign cutaneous and subcutaneous lesions, punch excision offers favorable cosmetic advantages due to its limited incision length. Across different indications, most evidence derives from small observational studies or case series, and long-term controlled data remain limited. Overall, punch-based techniques provide precise and tissue-preserving therapeutic options in dermatologic surgery; however, their clinical value varies substantially depending on the specific indications. Further standardized and prospective studies are needed to clarify their long-term efficacy and optimal positioning within treatment algorithms.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"588240"},"PeriodicalIF":2.2,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077225/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Effects of Diet on Atopic Dermatitis: A Mendelian Randomization Study Implicating Lipid Pathways and Clinical Implications.","authors":"Xiaowen Wen, Qili Xiao, Suitian Wang, Jing Wu, Shiyi Li, Teng Yu, Meng Zhou","doi":"10.2147/CCID.S590088","DOIUrl":"https://doi.org/10.2147/CCID.S590088","url":null,"abstract":"<p><strong>Background: </strong>Dietary fat quality and carbohydrate processing shape lipid and lipoprotein profiles involved in skin barrier integrity and cutaneous inflammation relevant to atopic dermatitis (AD). We assessed the causal relevance of dietary patterns and food items to AD and mapped lipid-lipoprotein mediators.</p><p><strong>Methods: </strong>We conducted a two-sample Mendelian randomization using genome-wide significant instruments for 83 UK Biobank diet traits and 241 serum lipid/lipoprotein measures, with AD cases from FinnGen R10 (European ancestry). Primary analyses used inverse-variance weighted MR with extensive sensitivity analyses, false discovery rate control, reverse MR, and multivariable MR. Mediation was assessed using the product-of-coefficients approach. Instrument strength was adequate (median <i>F</i> > 10).</p><p><strong>Results: </strong>Using two-step Mendelian randomization, we identified specific dietary items with causal effects on AD risk. Notably, a dietary pattern characterized by higher unsaturated fats-exemplified by the protective effect of \"other oil‑based spreads\"-was associated with lower AD risk (OR = 0.56, 95% CI 0.34-0.93, <i>P</i> = 0.023). Conversely, a pattern reflecting refined-grain intake, represented by the risk-increasing effect of \"brown bread\", was associated with higher AD risk (OR = 1.78, 95% CI 1.10-2.89, <i>P</i> = 0.01). Mediation analyses mapped the underlying lipid pathways: sphingomyelin SM C20:2 mediated 15.9% of the protective effect of oil-based spreads (<i>β</i> _mediation = -0.09, <i>P</i> = 0.003), and VLDL particle measures mediated 8.9% of the risk associated with brown bread (<i>β</i> _mediation = 0.05, <i>P</i> = 0.003). A complex antagonistic mediation was observed for muesli via phosphatidylcholine PC aa C36:0 (proportion mediated: -13.6%, <i>P</i> < 0.001). Reverse MR analyses supported the proposed direction of causality (all <i>P</i> > 0.05), and findings were robust across sensitivity analyses.</p><p><strong>Conclusion: </strong>Dietary patterns high in unsaturated fats, particularly oil-based spreads, appear protective against AD, while refined-grain intake, especially brown bread and black bread, increases AD risk. These effects are mediated through lipid pathways involving sphingomyelins and VLDL metabolism, highlighting modifiable nutritional targets for AD prevention and adjunctive management.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"590088"},"PeriodicalIF":2.2,"publicationDate":"2026-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13077330/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147688661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Injectable Fillers for Atrophic Acne Scars: A Systematic Review of Mechanisms, Evidence, and Clinical Algorithms.","authors":"Anqi Tao, Ye Shu, Hao Ding, Gefang Tao","doi":"10.2147/CCID.S602580","DOIUrl":"https://doi.org/10.2147/CCID.S602580","url":null,"abstract":"<p><strong>Background: </strong>Acne affects 9.4% of the global population, with the highest prevalence among adolescent males (12-25 years of age). More than 95% of patients develop persistent scarring, predominantly atrophic acne scars (AAS). These scars markedly impair facial aesthetics, psychological well-being, and quality of life, and increase the risk of depression and suicidal ideation. Conventional therapies (eg, Dermabrasion, Subcision and Traditional Ablative Lasers) show limited efficacy for shallow AAS and are associated with procedural pain, delayed onset of improvement, and a need for repeated sessions. Dermal fillers provide a promising alternative by delivering immediate volumetric correction and aesthetic enhancement while also stimulating long-term collagen production with minimal invasiveness and favorable safety profiles. They therefore represent a novel therapeutic approach for AAS.</p><p><strong>Aim: </strong>This review systematically evaluates the clinical utility of dermal fillers for treating AAS and explores future diagnostic and therapeutic approaches.</p><p><strong>Methods: </strong>We searched the PubMed and Web of Science databases for studies published in the past 10 years, categorizing and evaluating the efficacy and adverse effects of different dermal fillers for treating AAS.</p><p><strong>Results: </strong>Twenty-four studies met inclusion criteria, involving collagen-based fillers, hyaluronic acid fillers, collagen stimulator fillers, autologous fat, and decellularized matrix fillers. All filler types demonstrated significant scar improvement. Effects ranged from 3-6 months to >24 months. CaHA, PCL, and autologous fat/SVF demonstrated ≥6-month durability. Transient erythema, edema, and ecchymosis were common. Infrequent events included nodules and hyperpigmentation. No severe complications were reported.</p><p><strong>Conclusion: </strong>Multiple studies indicate that dermal fillers offer advantages over conventional therapies for atrophic scars. They provide immediate volumetric correction and stimulate long-term collagen production, with less tissue trauma than traditional approaches. Specific formulations also enhance skin hydration and may slow aging processes. Collectively, these benefits demonstrate substantial clinical promise, particularly when incorporated into combination therapies.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"602580"},"PeriodicalIF":2.2,"publicationDate":"2026-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13070406/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671116","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Prospective, Multicenter, Randomized, Assessor-Blinded Study Assessing the Efficacy and Safety of Injectable Non-Cross-Linked Hyaluronic Acid for Improving Facial Skin Rejuvenation.","authors":"Haiyan Cheng, Meng Jiang, Shan Zhong, Xinhai Liu, Dongsheng Cao, Qiuyuan Feng, Yongzhong Li, Wei Xu","doi":"10.2147/CCID.S590699","DOIUrl":"https://doi.org/10.2147/CCID.S590699","url":null,"abstract":"<p><strong>Objective: </strong>To evaluate the efficacy and safety of an injectable non-cross-linked hyaluronic acid (NCHA) solution in improving facial skin appearance.</p><p><strong>Methods: </strong>This prospective, multicenter, randomized, no‑treatment-controlled, assessor-blinded, superiority clinical trial was conducted from December 2023 to July 2024 with 448 adults (224 per arm). The treatment group received full-face intradermal injections of NCHA (4 mL/session) at baseline, day 28, and day 56; the control group followed routine skincare and underwent the same injection protocol after day 84. The treatment group underwent skin hydration measurement, elasticity measurement (two objective assessments), global aesthetic improvement scale, skin roughness score, and fine line score (three subjective assessments) at baseline; day 28 and 56; and 7/14/28 days after the last injection (day 63/70/84). The control group completed the same assessments at baseline, 28, 56, 63, 70, and 84 days after randomization.</p><p><strong>Results: </strong>In the treatment group, 212 subjects (94.64%) completed the study, compared to 209 (93.3%) in the control group. Hydration increased steadily in the treatment group, exceeding that of the control at all post-treatment time points (P<0.001). Elasticity improvements at 7/14/28 days after the final injection were significantly greater than those in the control group (P<0.05). GAIS, ASRS, and AFLS all favored the treatment arm. Serious adverse events were not observed.</p><p><strong>Conclusion: </strong>Full‑face intradermal NCHA improved skin hydration, elasticity, texture, and fine lines with a favorable safety profile.</p><p><strong>Chinese clinical trial registry: </strong>ChiCTR2300078169.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"590699"},"PeriodicalIF":2.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069964/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671092","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Clinical Spectrum of Dermatologic Conditions in Renal Transplant Recipients: A 10-Year Retrospective Cross-Sectional Study.","authors":"Mishari Tariq Alrubaiaan, Afnan Abdulrahman Almutairi, Leen Mohammed Altuwaijri, Nawaf Abdulaziz Alobaid, Lujain Amer Alharbi, Abdullah Taraiheb Alharbi, Haifa Saleh Alnamlah, Maisa Alfalah","doi":"10.2147/CCID.S598277","DOIUrl":"https://doi.org/10.2147/CCID.S598277","url":null,"abstract":"<p><strong>Background: </strong>The lifelong immunosuppressive therapy required to ensure graft survival in renal transplant recipients (RTRs) substantially increases their susceptibility to cutaneous infections, skin malignancies, and drug-induced dermatologic conditions. However, data on their prevalence and clinical spectrum remain limited.</p><p><strong>Objective: </strong>To determine the prevalence and clinical spectrum of dermatologic conditions among RTRs.</p><p><strong>Methods: </strong>A retrospective cross-sectional study design was performed using data extracted from the hospital health information system (BESTCare) to review the medical records of patients with renal transplantation who were referred for dermatologic evaluation over a ten-year period (2015-2025) at King Abdulaziz Medical City, Riyadh, Saudi Arabia (KAMC). Data analysis was conducted using SPSS (version 27.0). A multinomial logistic regression model was used to examine variables associated with dermatologic conditions.</p><p><strong>Results: </strong>A total of 338 RTRs were included; among them, 174 (51.5%) were female. Infectious conditions were the most prevalent (37.3%), followed by inflammatory (24%), drug-induced (12.4%), hair disorders (11.5%), and neoplastic (5.9%). Viral warts were the most common infectious condition (52 cases, 41.3%), followed by superficial fungal infections (23 cases, 18.3%). Among neoplastic conditions, seborrheic keratosis was the most common benign neoplasm (7 cases, 35.0%), while squamous cell carcinoma (6 cases, 30.0%) and basal cell carcinoma (4 cases, 20.0%) were the most common malignant neoplasms. In multinomial logistic regression, increasing age was independently associated with higher odds of neoplastic conditions (OR = 1.10 per year; 95% CI, 1.05-1.15; <i>p</i> < 0.001). Sex was significantly associated with dermatologic conditions, with males having higher odds of inflammatory conditions (OR = 1.30; <i>p</i> = 0.021), while females had higher odds of hair disorders (OR = 4.16; 95% CI, 1.82-9.53; <i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>Our study characterized the range of dermatologic conditions encountered in RTRs and highlighted the need to incorporate dermatologic screening and follow-up into multidisciplinary transplant care.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"598277"},"PeriodicalIF":2.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069955/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671065","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of Clinical Characteristics and Treatment Needs in Elderly Patients with Psoriasis Vulgaris: A Single-Centered Retrospective Study.","authors":"Boyang Zhou, Liyuan Sun, Jiannan Xu, Xiaoyang Wang","doi":"10.2147/CCID.S569554","DOIUrl":"https://doi.org/10.2147/CCID.S569554","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Psoriasis is a chronic, immune-mediated skin disorder that causes physical, psychological, and social burdens. There is a growing need to better characterize the distinct clinical features and specific treatment needs of elderly patients with psoriasis, which remains an important area for further research to optimize care in this population.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;To investigate the clinical characteristics, comorbidities, and treatment preferences of elderly patients with psoriasis vulgaris.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;Patients with psoriasis vulgaris were included in this retrospective study. Data on demographics, disease characteristics, including age at diagnosis, body surface area (BSA), Psoriasis Area and Severity Index (PASI), Dermatology Life Quality Index (DLQI), comorbidities, and treatment needs were collected. Patients at the visit over 60 years of age were defined as elderly patients. Patients who were diagnosed before 40 years of age were defined as early-onset psoriasis (EOP), and patients who were diagnosed over 40 years of age were defined as late-onset psoriasis (LOP). Continuous variables were compared using t-tests or Mann-Whitney &lt;i&gt;U&lt;/i&gt;-tests, categorical variables using Chi-square or Fisher's exact tests. Spearman correlation was used for association analysis. Statistical significance was set at &lt;i&gt;P&lt;/i&gt;&lt;0.05.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 375 patients were included, comprising 70 (18.67%) elderly and 305 (81.33%) non-elderly patients. The elderly group had a significantly higher proportion of LOP (87.14% vs 48.76%, &lt;i&gt;P&lt;/i&gt;&lt;0.05). A higher percentage of elderly patients had moderate-to-severe (27.14% vs 20.98%, &lt;i&gt;P&lt;/i&gt;&lt;0.05) and severe (1.43% vs 0.66%, &lt;i&gt;P&lt;/i&gt;&lt;0.05) disease. Comorbidities were more prevalent in the elderly, including cardiovascular disease (12.86% vs 3.93%, &lt;i&gt;P&lt;/i&gt;&lt;0.05) and diabetes (12.86% vs. 1.31%, &lt;i&gt;P&lt;/i&gt;&lt;0.05). Despite this, elderly patients reported lower DLQI scores (median 2.00 vs. 3.00, &lt;i&gt;P&lt;/i&gt;&lt;0.05). Regarding treatment needs, elderly patients were less likely to prioritize reducing treatment costs (10.00% vs 20.98%, &lt;i&gt;P&lt;/i&gt;&lt;0.05) and preventing disease recurrence (30.00% vs 44.26%,&lt;i&gt; P&lt;/i&gt;&lt;0.05) compared to non-elderly patients. Within the elderly cohort, EOP patients exhibited more severe disease (median BSA: 3.00 vs 2.00; median PASI: 3.30 vs 0.80, &lt;i&gt;P&lt;/i&gt;&lt;0.05), a higher rate of familial psoriasis (33.33% vs 4.92%, &lt;i&gt;P&lt;/i&gt;&lt;0.05), and a greater demand for reducing treatment costs (33.3% vs 6.56%, &lt;i&gt;P&lt;/i&gt;&lt;0.05) compared to LOP patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Elderly patients with psoriasis present a distinct clinical profile characterized by a high prevalence of late-onset disease, a significant comorbidity burden, and differing treatment priorities focused less on cost and recurrence. Despite the increased clinical severity, their perceived quality-of-life impact is lower. Besides, they report higher dissatisf","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"569554"},"PeriodicalIF":2.2,"publicationDate":"2026-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13069947/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147671118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resolution versus Reliability: Interpreting Ultra-High-Frequency Ultrasound in Melanoma Recurrence Detection [Letter].","authors":"İstem Şanal Çamur, Eren Çamur","doi":"10.2147/CCID.S611893","DOIUrl":"https://doi.org/10.2147/CCID.S611893","url":null,"abstract":"","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"611893"},"PeriodicalIF":2.2,"publicationDate":"2026-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13055907/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147638015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Impact of Targeted Therapies on the Bone-Vascular Axis in Psoriasis: A Narrative Review.","authors":"Huimei Zeng, Yourui Chen, Langhuan Yang","doi":"10.2147/CCID.S595065","DOIUrl":"https://doi.org/10.2147/CCID.S595065","url":null,"abstract":"<p><p>This narrative review elucidates the impact of biologics and small-molecule inhibitors on bone metabolism and cardiovascular risk in patients with psoriasis. Psoriasis is a systemic immune-mediated disorder characterized by a \"Calcification Paradox\"-the simultaneous occurrence of skeletal bone loss and vascular calcification. We explore the molecular mechanisms of the \"Bone-Vascular Axis\", highlighting how the IL-23/IL-17 axis disrupts the RANKL/OPG balance and drives the osteogenic transdifferentiation of vascular smooth muscle cells. We critically evaluate the therapeutic impact of targeted agents, noting that IL-23 and dual IL-17A/F inhibitors offer significant structural protection in psoriatic arthritis. Regarding oral therapies, while JAK inhibitors necessitate cardiovascular risk stratification, the novel TYK2 inhibitor deucravacitinib demonstrates a favorable cardiovascular safety profile based on long-term extension data, although large-scale, hard endpoint-driven cardiovascular outcome trials (CVOTs) remain necessary to confirm definitive long-term protection. We conclude that effective management must shift from skin-focused control to a comprehensive systemic strategy targeting the bone-vascular axis to mitigate long-term comorbidities.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"595065"},"PeriodicalIF":2.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13050986/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147632630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}