Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Hidradenitis Suppurativa Cancer Risk: A Review of the Literature.","authors":"Fabrizio Martora, Nello Tommasino, Teresa Battista, Luca Potestio, Matteo Megna","doi":"10.2147/CCID.S512373","DOIUrl":"10.2147/CCID.S512373","url":null,"abstract":"<p><strong>Background: </strong>This systematic review explores the increased cancer risk in patients with hidradenitis suppurativa (HS), particularly cutaneous squamous cell carcinoma (SCC) and lymphoma. Chronic inflammation and immune dysregulation in HS are identified as key factors contributing to malignant transformation, often observed in areas of prolonged tissue damage.</p><p><strong>Objectives and results: </strong>The NOTCH signaling pathway, disrupted by smoking, plays a dual role in cancer, acting as both a tumor suppressor and a proto-oncogene depending on the context. Mutations in NOTCH and TP53 are common in SCC linked to HS, with a prevalence of 0.5% to 4.6%, predominantly in men and localized to the buttock and anogenital regions. Histological analyses suggest that malignant transformation occurs within keratinized epithelium, supported by altered cytokeratin expression. Immune dysregulation in HS-affected areas, compounded by scarring and lymphatic disruption, further exacerbates tumorigenic potential. While anti-TNF-alpha therapies have been implicated in cancer risk, conflicting evidence and meta-analyses suggest no consistent increase in non-melanoma skin cancers (NMSC). Similarly, IL-17 inhibitors show potential risks but lack robust evidence in HS-specific populations.</p><p><strong>Conclusion: </strong>In conclusion, HS-associated malignancies, particularly SCC, underscore the need for further research to elucidate the mechanisms linking chronic inflammation to cancer development. Insights from such studies could guide preventative and therapeutic strategies, improving outcomes for HS patients.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"617-626"},"PeriodicalIF":1.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11929415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Analysis of Arachidonic Acid Metabolism in the Pathogenesis and Immune Dysregulation of Psoriasis.","authors":"Mengyi Hou, Yanting Sun","doi":"10.2147/CCID.S494806","DOIUrl":"10.2147/CCID.S494806","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is a chronic inflammatory skin disorder with complex molecular mechanisms. While previous studies have demonstrated altered levels of arachidonic acid and its metabolites in psoriatic lesions, the specific roles of arachidonic acid metabolism (AAM) genes in the molecular pathogenesis and immune dysregulation of psoriasis remain poorly understood. This study aimed to investigate the role of AAM genes in the pathogenesis and immune dysregulation of psoriasis using an integrative bioinformatics approach.</p><p><strong>Methods: </strong>Gene expression data from psoriasis patients and healthy controls were obtained from the Gene Expression Omnibus database and analyzed. Differentially expressed genes were identified, and functional enrichment analyses were performed. Weighted gene co-expression network analysis (WGCNA) and machine learning techniques were employed to identify psoriasis associated AAM genes. Single-sample gene set enrichment analysis (ssGSEA) and immune cell composition analysis were conducted to explore functional implications. Transcription factor prediction analysis was performed to identify potential regulators of key AAM genes.</p><p><strong>Results: </strong>Differential expression analysis revealed 469 dysregulated genes in psoriasis, with functional enrichment highlighting the involvement of epidermis development, immune response, and inflammation. WGCNA and machine learning approaches identified <i>ABCC1, PLA2G3, CYP2J2</i>, and <i>GPX2</i> as key AAM genes. ssGSEA showed elevated inflammation and immune response in psoriasis, with key AAM genes correlating with specific pathways. Immune cell composition analysis revealed increased infiltration of inflammatory cells in psoriatic skin. Transcription factor prediction analysis identified shared transcription factors for the key AAM genes, suggesting coordinated regulation of their expression in psoriasis.</p><p><strong>Conclusion: </strong>This integrative analysis identified key AAM genes associated with psoriasis pathogenesis and immune dysregulation, providing novel insights into the molecular basis of psoriasis. The findings highlight potential therapeutic targets and biomarkers, which could lead to improved diagnosis and treatment strategies for this chronic inflammatory skin disorder.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"601-615"},"PeriodicalIF":1.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11928300/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691516","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tru9I Variant as a Novel Genetic Marker for Vitamin D Deficiency in Alopecia Areata.","authors":"Ghadah Alhetheli, Mohammed Saleh Al-Dhubaibi, Saleh Salem Bahaj, Sharif Alhajlah, Ahmed Ibrahim AbdElneam","doi":"10.2147/CCID.S504475","DOIUrl":"10.2147/CCID.S504475","url":null,"abstract":"<p><strong>Introduction: </strong>Alopecia areata (AA), is a common autoimmune nonscarring alopecia. Vitamin D is involved in various biological processes such as immune regulation, cellular growth, and specialization, as well as the maintenance of the hair cycle. We aimed to explore the impact of different Tru9I variant genotypes on serum vitamin D levels and vitamin D receptor (VDR) gene expression.</p><p><strong>Methods: </strong>Case-control study that included 72 individuals diagnosed with AA, along with age and sex matched healthy controls of 72 individuals. Blood samples were obtained to measure Vitamin D level and VDR gene expression focusing on Tru9I variant genotypes.</p><p><strong>Results: </strong>Our findings indicate, for the first time, a possible association between the \"U\" allele and low vitamin D levels, along with altered activity of the VDR gene as observed in patients with AA.</p><p><strong>Conclusion: </strong>This suggests a complex causal relationship between genetic factors and vitamin D in AA. Interestingly, \"u\" allele was found to be significantly more prevalent in the healthy control group than in the patients group, raising the possibility of its protective mechanism against the development of this disease in healthy individuals.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"593-600"},"PeriodicalIF":1.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11927502/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143691518","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Causal Relationship Between Circulating Metabolites and the Risk of Atopic Dermatitis: A Two-Sample Mendelian Randomization Study.","authors":"Jian Chen, Dan Jian, Bingxue Bai","doi":"10.2147/CCID.S484813","DOIUrl":"10.2147/CCID.S484813","url":null,"abstract":"<p><strong>Background: </strong>Previous research has shown that metabolites (especially lipid-related metabolites) have a significant influence in the development of atopic dermatitis (AD). However, there is no evidence of a causal connection between metabolites and AD risk. The specific mechanisms require further elucidation. Our study employed a two-sample Mendelian randomization (TSMR) strategy to investigate how metabolite traits affect AD.</p><p><strong>Methods: </strong>Utilizing publicly accessible GWAS data, we conducted TSMR studies to investigate the relationship between 233 metabolites traits (213 lipid-related traits and 20 no lipid-related traits) and AD. Our TSMR study primarily employed the Inverse-variance weighted method and four ancillary methods to analyze causation. Sensitivity analysis was performed to guarantee the TSMR results were trustworthy. Reverse MR analysis was used for investigating reverse causality.</p><p><strong>Results: </strong>After analyzing GWAS datasets for metabolites and AD, 13 metabolites were identified as positive. The MR analysis result indicates that total cholesterol in very small VLDL, cholesterol esters in very small VLDL, free cholesterol in IDL, concentration of medium LDL particles, concentration of large LDL particle, concentration of chylomicrons and extremely large VLDL particles, triglyceride levels in chylomicrons and extremely large VLDL, total lipid levels in chylomicrons and extremely large VLD, phospholipid levels in chylomicrons and extremely large VLDL, phospholipids in medium LDL, phospholipids in large LDL, phospholipids in small LDL, ratio of 18:2 linoleic acid to total fatty acids exhibited negative effects on AD. Reverse MR result analysis found that ratio of 18:2 linoleic acid to total fatty acids in serum was decreased in patients with AD. Sensitivity analyses ensure the stability of our results.</p><p><strong>Conclusion: </strong>These findings highlight a definite correlation between metabolite and AD, demonstrating the significant role of 13 lipid-related metabolite traits. Our results significantly reduced the influence of unavoidable confounders and reverse causality. Our findings may set the framework for prospective therapeutic approaches and call for further investigation to validate them.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"567-577"},"PeriodicalIF":1.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring Causal Relationships Between Gut Microbiota, Inflammatory Cytokines, and Inflammatory Dermatoses: A Mendelian Randomization Study.","authors":"Zirui Huang, Tao Lu, Jiahua Lin, Qike Ding, Xiaoting Li, Lihong Lin","doi":"10.2147/CCID.S496091","DOIUrl":"10.2147/CCID.S496091","url":null,"abstract":"<p><strong>Background: </strong>Some studies have established a link between gut microbiota, inflammatory proteins, and inflammatory dermatoses. However, the mediating role of inflammatory proteins in the gut-skin axis remains unclear.</p><p><strong>Methods: </strong>Data on inflammatory proteins and gut microbiota were drawn from the GWAS catalog and MiBioGen consortium, with inflammatory skin disease data provided by the FinnGen consortium. Using genome-wide association studies (GWAS), we performed linkage disequilibrium score regression (LDSC) to assess genetic correlations and conducted a two-step Mendelian Randomization (MR) analysis to investigate circulating inflammatory proteins as potential mediators between gut microbiota and inflammatory dermatoses.</p><p><strong>Results: </strong>MR analysis identified 38 gut microbiota and 23 inflammatory proteins associated with inflammatory skin diseases. After false discovery rate (FDR) correction, four gut microbiota taxa-<i>Eubacterium fissicatena, Bacteroidaceae, Allisonella</i>, and <i>Bacteroides</i>, remained statistically significant (OR = 1.32, 95% CI: 1.16-1.50, <i>adjusted P</i> = 0.007; OR = 2.25, 95% CI: 1.48-3.42, <i>adjusted P</i> = 0.026; OR = 1.42, 95% CI: 1.18-1.70, <i>adjusted P</i> = 0.014; OR = 2.25, 95% CI: 1.48-3.42, <i>adjusted P</i> = 0.013), with only IL-18R1 significantly associated with eczema (OR = 1.05, 95% CI: 1.03-1.08, <i>adjusted P</i> = 0.017). Further mediation analysis showed that IL-15RA mediated 11% of the pathway between <i>Veillonellaceae</i> and eczema, while FGF19 mediated 6% of the pathway between genus <i>LachnospiraceaeUCG001</i> and psoriatic arthritis.</p><p><strong>Conclusion: </strong>These findings provide potential targets for therapeutic interventions in inflammatory skin diseases.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"579-592"},"PeriodicalIF":1.9,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11912934/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cathepsins and Skin Cancer (Malignant Melanoma, Basal Cell Carcinoma, and Squamous Cell Carcinoma): Insight From Genetic Correlation and Mendelian Randomization.","authors":"Xianglong Li, Shaofeng Yang, Zhong Du, Wanying Xie, Man Zhu, Ling Han, Qingyu Zhou","doi":"10.2147/CCID.S502013","DOIUrl":"https://doi.org/10.2147/CCID.S502013","url":null,"abstract":"<p><strong>Background: </strong>Multiple studies have indicated that cathepsins (Cats) play a crucial role in the development and progression of skin cancer. However, most of these studies are observational and may be influenced by external variables, necessitating further research to establish causal relationships.</p><p><strong>Methods: </strong>We conducted a two-sample, two-way Mendelian randomization (MR) study utilizing pooled data from genome-wide association studies (GWAS) to evaluate the causal association between 9 Cats (Cat-B, E, F, G, H, L2, O, S, and Z) and 3 types of skin cancer, including malignant melanoma (MM), basal cell carcinoma (BCC), and squamous cell carcinoma (SCC). Our analysis employed several methods, including inverse variance weighting (IVW), MR-Egger, weighted median, Cochran's <i>Q</i> test, the MR-Egger intercept test, and leave-one-out sensitivity analysis. Furthermore, bioinformatics analysis of loci linked to Cats and skin cancer was performed to explore potential molecular mechanisms.</p><p><strong>Results: </strong>Genetically predicted increases in Cat-F and Cat-O levels were found to be correlated with a higher risk of BCC, while increased levels of Cat-L2 and Cat-O were associated with a reduced incidence of SCC. Bioinformatics analysis suggested that differentially expressed genes located near Cats-related loci could potentially influence BCC and SCC by modulating relevant signaling pathways and the tumor microenvironment.</p><p><strong>Conclusion: </strong>Our research indicated a causal link between Cats and skin cancer. By conducting a bioinformatic analysis of genetic loci related to Cats and skin cancer, we were able to gain a better understanding of the potential molecular mechanisms driving this association. This research can provide valuable insights into the diagnosis and treatment of skin cancer.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"553-566"},"PeriodicalIF":1.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11910913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Safety of the Use of 1470 nm Laser Therapy in Patients Suffering From Acne Scarring of the Facial Skin.","authors":"Paweł Kubik, Stefano Bighetti, Luca Bettolini, Wojciech Gruszczyński, Bartłomiej Łukasik, Stefania Guida, Giorgio Stabile, Elisa Maria Murillo Herrera, Andrea Carugno, Edoardo D'Este, Nicola Zerbinati","doi":"10.2147/CCID.S510208","DOIUrl":"10.2147/CCID.S510208","url":null,"abstract":"<p><strong>Purpose: </strong>This prospective, single-center, open-label study aimed to evaluate the efficacy and safety of 1470 nm non-ablative laser therapy in treating facial acne scars. The primary objective was to assess improvements in skin texture, elasticity, and scar depth and diameter, while confirming the absence of significant adverse effects.</p><p><strong>Patients and methods: </strong>40 healthy female volunteers aged 18 to 42 years with facial acne scars underwent three sessions of 1470 nm laser therapy at two-week intervals. Outcome measures included cutometric assessments, high-frequency ultrasound evaluations, and clinical photographic documentation, conducted at baseline and on days 21, 42, 70, and 130 post-treatment.</p><p><strong>Results: </strong>Significant improvements were observed across all evaluated parameters. Skin elasticity increased progressively from baseline (mean: 62.95, SD=4.0) to day 21 (63.72, SD=3.8, +4%), day 42 (67.11, SD=4.0, +6%), day 70 (69.08, SD=4.2, +11%), and day 130 (70.80, SD=4.4, +14%; p<0.001). High-frequency ultrasound measurements revealed substantial reductions in scar depth, which decreased by 5% at day 21 (mean: 0.18 mm, SD=0.05, p<0.001), 20% at day 42 (0.15 mm, SD=0.055, p<0.001), 48% at day 70 (0.10 mm, SD=0.06, p<0.001), and 63% at day 130 (0.07 mm, SD=0.065, p<0.001). Scar diameter followed a similar trend, with reductions of 16% at day 21 (3.08 mm, SD=0.3, p<0.001), 26% at day 42 (2.71 mm, SD=0.34, p<0.001), 42% at day 70 (2.13 mm, SD=0.36, p<0.001), and 62% at day 130 (1.39 mm, SD=0.38, p<0.001). Clinical photographic evaluations corroborated these quantitative findings, showing visible improvements in scar appearance and overall skin texture. No adverse events were reported throughout the study.</p><p><strong>Conclusion: </strong>The 1470 nm non-ablative laser therapy demonstrated high efficacy and safety in the treatment of acne scars, delivering substantial therapeutic benefits and high patient satisfaction, offering a valuable therapeutic option for addressing both pigmentation and textural issues associated with acne scars.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"543-551"},"PeriodicalIF":1.9,"publicationDate":"2025-03-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11911818/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143647588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential Applications of Chitosan in Seborrheic Dermatitis and Other Skin Diseases: A Comprehensive Review.","authors":"Youting Liu, Jianli Shang, Yong Chen, Xiaoyue Feng","doi":"10.2147/CCID.S504778","DOIUrl":"10.2147/CCID.S504778","url":null,"abstract":"<p><p>This review article explores the potential applications of chitosan, a natural polysaccharide derived from crustacean shells, in the treatment of seborrheic dermatitis (SD) and other skin diseases. SD is a common chronic inflammatory skin condition characterized by erythema, scaling, itching, and an oily appearance, predominantly affecting areas rich in sebaceous glands. Current treatments, including antifungal agents, corticosteroids, and calcineurin inhibitors, offer symptomatic relief but have limitations in long-term use due to side effects and resistance issues. Chitosan exhibits excellent biocompatibility, biodegradability, and broad-spectrum antibacterial properties, making it a promising candidate for SD treatment. This review highlights chitosan's multifunctional properties such as antimicrobial, anti-inflammatory, sebum-regulating, and barrier-enhancing effects, which are closely related to the pathogenesis of SD. Additionally, the article summarizes the applications of chitosan in other skin conditions, including wound healing, infectious skin diseases, and atopic dermatitis, demonstrating its broad therapeutic potential. Through this comprehensive evaluation, the review aims to provide a theoretical foundation for clinical research on chitosan in SD and support the development of new, safer, and more effective treatment options for various skin conditions.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"533-542"},"PeriodicalIF":1.9,"publicationDate":"2025-03-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11894430/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS): A Retrospective Study of 51 Chinese Patients.","authors":"Xiaoxue Li, Yanmei Li, Lian Liu, Lian Wang, Lidan Zhang, Xian Jiang","doi":"10.2147/CCID.S486550","DOIUrl":"10.2147/CCID.S486550","url":null,"abstract":"<p><strong>Background: </strong>Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe and potentially lethal adverse drug reaction. Its clinical complexity and heterogeneity pose challenges for diagnosis and management.</p><p><strong>Methods: </strong>We retrospectively reviewed the medical records of patients with DRESS who were admitted to our hospital between 2013 and 2022. Data on demographics, culprit drugs, clinical manifestations, laboratory findings, and treatments were collected.</p><p><strong>Results: </strong>Fifty-one patients were included in the final analysis, with 16 probable and 35 definite cases. The most common causative drugs were antiepileptic drugs (15.7%), anti-tuberculosis drugs (15.7%), and Chinese herbs (9.8%). Common skin manifestations included extensive skin involvement (76.5%), facial edema (66.7%), polymorphic maculopapular lesions (66.7%), and exfoliation (56.9%). Eosinophilia and atypical lymphocytes were noted in 96.1% and 68.6% of the patients, respectively. The liver is the most frequently affected organ. Facial edema, extensive skin involvement, and atypical lymphocytes were correlated with higher Registry of Severe Cutaneous Adverse Reactions (RegiSCAR) scores (<i>P</i><0.05). DRESS induced by antiepileptic drugs, antituberculosis drugs, and Chinese herbs exhibited significant differences in platelet and lymphocyte counts, C-reactive protein (CRP) levels, and transaminase levels (<i>P</i><0.05).</p><p><strong>Conclusion: </strong>Clinical manifestations of DRESS are complex. Facial edema, extensive skin involvement, and atypical lymphocytes have emerged as significant diagnostic indicators.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"525-532"},"PeriodicalIF":1.9,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11890001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy and Safety Evaluation of 595 nm Pulsed Dye Laser Treatment in 120 Cases of Asian Infants With Port Wine Stain.","authors":"Yiqun Guo, Hua Jiang, Yizhou Jiang, Xiaoyun Tan, Haibo Li, Jiejun Xia, Zhen-Yin Liu","doi":"10.2147/CCID.S489305","DOIUrl":"10.2147/CCID.S489305","url":null,"abstract":"<p><strong>Introduction: </strong>This study aimed to evaluate the efficacy and safety of a 595 nm pulsed dye laser (PDL) for the treatment of port wine stain (PWS) in 120 Asian infant patients.</p><p><strong>Methods: </strong>A retrospective analysis was carried out to assess the efficacy and safety of 595 nm PDL in 120 Asian infant patients with PWS.</p><p><strong>Results: </strong>This study identified excellent (21.67%), good (23.33%), fair (30.83%), and poor (15.83%) clearance. Multiple treatments significantly improved efficacy, with 61.56% of patients achieving good or excellent responses after more than six sessions. Younger patients showed better treatment outcomes than older patients did. The lesion location influenced the response, with leg lesions exhibiting the poorest response. The pink lesions were the most susceptible, whereas the purple lesions displayed the least response. Smaller lesions (<10 cm²) showed a size-dependent excellent rate (41.0%) and lower poor rate (5.1%).</p><p><strong>Conclusion: </strong>The 595 nm PDL treatment displayed a favorable safety profile, with only mild, well-tolerated adverse effects. Rare adverse effects were resolved within 3-6 months. No severe adverse events were reported. The 595 nm PDL is safe and effective for Asian infant patients with PWS. The side effects were mild and well-tolerated by the patients.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"503-509"},"PeriodicalIF":1.9,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11887490/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143584977","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}