Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Evidence of a Causal Relationship Between Body Mass Index and Immune-Mediated and Inflammatory Skin Diseases and Biomarkers: A Mendelian Randomization Study.","authors":"Zhaoyi Li, Yibin Zhao","doi":"10.2147/CCID.S496066","DOIUrl":"10.2147/CCID.S496066","url":null,"abstract":"<p><strong>Aim: </strong>Increasing observational studies are revealing a positive correlation between body mass index (BMI) and the risk of Immune-mediated and Inflammatory Skin Diseases (IMID), however the causal relationship is not yet definite.</p><p><strong>Objective: </strong>The aim of the study was to conduct a two-sample Mendelian randomization (TSMR) to explore the potential causality between BMI, and IMID and biomarkers.</p><p><strong>Methods: </strong>The summary statistics for BMI (n = 322,154), at genome-wide significant level, were derived from the Genetic Investigation of Anthropometric Traits consortium (GIANT). The outcome data for IMID (Psoriasis, vitiligo, Atopic dermatitis (AD), acne, Bullous diseases, Dermatitis herpetiformis, Systemic lupus erythematosus (SLE), Alopecia Areata (AA), Hidradenitis suppurativa (HS) and Systemic sclerosis), and biomarkers were obtained from genome-wide association studies (GWAS). The TSMR analyses were performed in four methods, including inverse variance weighted (IVW) method, MR-Egger regression, the weighted median estimator (WME) and simple mode.</p><p><strong>Results: </strong>The IVW analysis showed that the per standard deviation (SD) increase in BMI increased a 57% risk of psoriasis. We also observed the suggestive evidence of a causal relationship between BMI and AD and HS. This analysis did not support causality of Vitiligo, Acne, Bullous pemphigoid, Dermatitis herpetiformis, SLE, AA and Systemic sclerosis. The higher risk of BMI may be explained by higher levels of Triglycerides, C-reactive protein (CRP), Interleukin 6, Erythrocyte sedimentation rate (ESR) and Neutrophil count. The high-density lipoprotein (HDL) has an inverse relationship with BMI. No influences were defined for Total cholesterol, low-density lipoprotein (LDL), Rheumatoid factor (RF), Basophil count and Eosinophil count.</p><p><strong>Conclusion: </strong>Our two-sample MR analysis proved the causal evidence for the associations between BMI and IMID, including psoriasis, AD and HS, which might be related to the elevated expression of biomarkers, including Triglycerides, CRP, Interleukin 6, ESR and neutrophil count.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2659-2667"},"PeriodicalIF":1.9,"publicationDate":"2024-11-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Likelihood of Resistant Tinea Capitis Caused by Hortaea Werneckii: A Case Report.","authors":"Wenai Zheng, Ming Zhang, Weiwei Wu, Xiaozheng Tang, Zhaobing Pan","doi":"10.2147/CCID.S489139","DOIUrl":"10.2147/CCID.S489139","url":null,"abstract":"<p><p>This case study illustrates a 24-year-old Chinese man who presented with tinea capitis associated with a fungal infection. He was administered a therapeutic regimen consisting of terbinafine, ketoconazole cream, and miconazole shampoo for 2 months. However, the symptoms recurred 3 months after the treatment ended. Fungal culture and sequencing confirmed the infection of Hortaea werneckii. Drug sensitivity testing showed that the infecting strain of the patient remained sensitive to the five commonly used antifungal drugs in vitro. While most cases infected by Hortaea werneckii present with Tinea nigra, the possibility of Hortaea werneckii infection should be considered in patients with tinea capitis living in coastal cities.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2653-2657"},"PeriodicalIF":1.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590628/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Giant Scapular Vascular Eccrine Spiroadenomas: A Rare Case Report.","authors":"Xiaole Zheng, Min Li, Ruiye Huang, Yang Lu, Jiejie Lu, Weiwei Wu","doi":"10.2147/CCID.S491698","DOIUrl":"10.2147/CCID.S491698","url":null,"abstract":"<p><p>Giant vascular eccrine spiradenoma (GVES) is a dermal adnexal neoplasm, representing a malignant variant of eccrine spiradenoma. We report a case of giant scapular vascular eccrine spiroadenomas. This case is characterized by its large size and location in a region with sparse vascular distribution, along with a favorable postoperative prognosis, which merits reporting.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2649-2652"},"PeriodicalIF":1.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590624/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142725861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Implications of pH and Ionic Environment in Chronic Diabetic Wounds: An Overlooked Perspective.","authors":"Jing Guo, Yi Cao, Qing-Yuan Wu, Yi-Mai Zhou, Yuan-Hao Cao, Lu-Sha Cen","doi":"10.2147/CCID.S485138","DOIUrl":"10.2147/CCID.S485138","url":null,"abstract":"<p><p>The high incidence of disability and fatality rates associated with chronic diabetic wounds are difficult problems in the medical field. The steady-state and regular changes of the microenvironment in and around the wound provide good conditions for wound healing and achieve a dynamic and complex process of wound healing.The pH value and ionic environment composed of a variety of ions in wound are important factors affecting the wound microenvironment, and there are direct or indirect connections between them. Abnormalities in pH, ion concentrations, and channels in skin tissue may be one of the reasons for the high incidence and difficulty in chronic diabetic wounds healing. Currently, different wound-dressing applications have been developed based on the efficacy of ions. Here, the effect of pH in wounds, concentrations of calcium (Ca²⁺), sodium (Na⁺), potassium (K⁺) and the metal ions silver (Ag⁺), copper (Cu²⁺), iron (Fe²⁺/Fe³⁺), zinc (Zn²⁺), and magnesium (Mg²⁺) in skin tissue, their roles in wound healing, and the application of related dressings are reviewed. This manuscript provides new ideas and approaches for future clinical and basic research examining the treatment of chronic diabetic wounds by adjusting ion concentrations and channels.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2669-2686"},"PeriodicalIF":1.9,"publicationDate":"2024-11-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11590674/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726162","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Mixture of Water-Soluble Polysaccharides Reduces Caspase-1 and IL-1β Inflammatory Responses by <i>Cutibacterium acnes</i> in vitro in Reconstructed Human Epidermis (RHE).","authors":"James V Gruber, Nicole Terpak, Sebastien Massard, Xiang Chen, Yurah Kim","doi":"10.2147/CCID.S487881","DOIUrl":"10.2147/CCID.S487881","url":null,"abstract":"<p><strong>Introduction: </strong>It is well established that <i>Cutibacterium acnes</i> (<i>C. acnes</i>) is a common skin commensal microorganism that has been linked to acne. In acne flare-ups, <i>C. acnes</i> can be found in abundant levels within the inflammatory lesions (called comedones) associated with the skin disease. Recently, it was reported that 3D reconstructed human epidermis (RHE) treated with viable cultures of <i>C. acnes</i> can elicit β-defensin antimicrobial peptide responses in the skin and can weaken the skin barrier of the RHE after three days of exposure to <i>C. acnes</i>.</p><p><strong>Methods: </strong>Employing a modification of this in vitro assay, RHE was pretreated with <i>C. acnes</i> for 48 hours, then further treated with a mixture of water-soluble polysaccharides (STRATAPHIX™ POLY, \"Polysaccharide Blend\") previously shown to reduce inflammasome-mediated inflammatory responses in normal human epidermal keratinocytes (NHEK). Two inflammasome-mediated inflammation markers were tested, including caspase-1, a potent protease enzyme activated by NOD-like receptor protein (NLRP)-induced inflammasome activation, and interleukin-1β (IL-1β), a cytokine which is activated from inactive pro-IL-1β by caspase-1.</p><p><strong>Results: </strong>The treatment of the RHE tissues with <i>C. acnes</i> for 48 hours elicited an inflammatory response measured with both markers compared against untreated tissues. Treatment of the tissues with 1% and 2% salicylic acid for 24 hours after <i>C. acnes</i> treatment increased the inflammatory response measured with both markers. Application of the water-soluble polysaccharides in combination with 1% and 2% of salicylic acid significantly reduces expression of both active caspase-1 and IL-1β compared against the tissues treated with <i>C. acnes</i> and salicylic acid alone.</p><p><strong>Discussion: </strong>The results lend further support to previously reported work which was done on NHEKs treated with ultraviolet B (UVB) light and adenosine triphosphate (ATP) and demonstrate that the same mixture of polysaccharides can have a modulating effect against bacterial and chemical induced inflammation in RHE.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2627-2633"},"PeriodicalIF":1.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587798/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Trend and Future Perspectives of Traditional Chinese Medicine for Atopic Dermatitis from 2004 to 2023: A Bibliometric Analysis.","authors":"Huishang Feng, Yeping Qin, Yuanwen Li, Shuo Li, Yuyi Zheng, Juntang Yan, Rongting Xu, Shulin Yu, Ru Liang, Jiayu Wang, Huiqin Zou","doi":"10.2147/CCID.S479632","DOIUrl":"10.2147/CCID.S479632","url":null,"abstract":"<p><strong>Aim: </strong>The application of bibliometric analysis gives insights into research trend and future perspectives. This paper aims to understand the current status of studies on traditional Chinese medicine (TCM) in the treatment of atopic dermatitis (AD), and to investigate the cooperation network, hotspots and trends in the field.</p><p><strong>Methods: </strong>The original data were retrieved from the Web of Science Core Collection by searching for the topic \"atopic dermatitis\" and \"traditional Chinese medicine\" with the time span of 2004-2023. Microsoft Excel was used to create statistical tables and charts, whereas CiteSpace and VOSViewer were applied for knowledge mapping.</p><p><strong>Results: </strong>In total, 252 publications were identified and downloaded. Current research on TCM treating AD is in the steady growth period. China has the largest number of publications, whereas the USA has the greatest international influence. Notably, the Arab Emirates, Malaysia, India and Bangladesh all have a high research impact but with a low amount of publications. Universities in Hong Kong China have the largest number of publications, but their interaction with other institutions is very poor. The top three most productive authors are all from Hong Kong, having a strong collaboration network with each other. The popular research topics in this field are \"children\" \"cell\" \"activation\" \"nf kappa b\" \"inflammation\" \"asthma\" \"extract\" \"management\" and \"cytokine\". According to the analysis of leading co-cited journals and authors, \"J ETHNOPHARMACOL\" has the largest amount of citations whilst \"AM J CHINESE MED\" the strongest academic influence. The largest number of co-cited authors comes from \"Hon Karn-Lun Ellis\", a well-known scholar from Hong Kong.</p><p><strong>Conclusion: </strong>TCM has been widely used in AD treatment, honored for its individualized therapeutic concepts of evidence-based treatment. The academic community must form a continuous and deep-going pattern to achieve higher international influence and a stronger research degree in this field.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2595-2613"},"PeriodicalIF":1.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11588668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142726254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and Socio-Demographic and Hygiene Factors Influencing Impetigo in Saudi Arabian Children: A Cross-Sectional Investigation.","authors":"Ali M Aleid, Houriah Y Nukaly, Lina K Almunahi, Ahood A Albwah, Rahaf Masoud D Al-Balawi, Mohsen H AlRashdi, Ola A Alkhars, Awatif M Alrasheeday, Bushra Alshammari, Yasmine Alabbasi, Abbas Al Mutair","doi":"10.2147/CCID.S472228","DOIUrl":"10.2147/CCID.S472228","url":null,"abstract":"<p><strong>Purpose: </strong>To determine the prevalence of impetigo among children in Saudi Arabia as well as to identify socio-demographic factors associated with impetigo.</p><p><strong>Methods: </strong>This cross-sectional study conducted in Saudi Arabia examined impetigo prevalence and associated factors among children aged 2 to 15. Data collection occurred between June 2022 and November 2023, involving structured interviews with the parents or legal guardians of the participating children. A pre-designed questionnaire was used, which included questions related to personal hygiene practices (such as, frequency of handwashing, bathing routines, and use of communal facilities), environmental conditions, and the child's impetigo diagnosis history.</p><p><strong>Results: </strong>The study encompassed a total of 1200 participants, with a predominant representation of female (79.3%). Participants exhibited a diverse age distribution, with the highest proportion falling within the 18-24 age group (33.7%). Importantly, a statistically significant association was identified between the occurrence of impetigo in children and their personal hygiene scores (p < 0.001). Children with a confirmed impetigo diagnosis exhibited lower mean personal hygiene scores (2.6 ± 0.723) in contrast to those without such diagnoses (3.75 ± 0.911).</p><p><strong>Conclusion: </strong>Socio-demographic factors, including child's gender, parental education level, employment status, and geographic location, emerge as significant determinants of impetigo occurrence. Additionally, there is a strong correlation between proper personal hygiene practices and a reduced incidence of impetigo.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2635-2648"},"PeriodicalIF":1.9,"publicationDate":"2024-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11600433/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142738608","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Novel Prognostic Markers for Skin Cutaneous Melanoma.","authors":"Yi Zhang, Ansheng Xie, Di Wang, Weiwei Deng","doi":"10.2147/CCID.S486679","DOIUrl":"10.2147/CCID.S486679","url":null,"abstract":"<p><strong>Background: </strong>Skin cutaneous melanoma (SKCM) ranks among the most prevalent malignant tumors, highlighting the significance of identifying new research targets. In this study, our objective was to pinpoint pivotal genes implicated in SKCM pathogenesis and ascertain their potential as prognostic biomarkers.</p><p><strong>Methods: </strong>Leveraging data from 1809 normal skin samples and 471 SKCM samples, we identified differentially expressed genes (DEGs). Using a comprehensive suite of bioinformatic analyses, including weighted gene co-expression network analysis (WGCNA), we elucidated the functions of these DEGs and singled out hub genes. Cox analyses and overall survival analyses underscored that elevated expression of these genes correlated with more favorable prognoses.</p><p><strong>Results: </strong>Ultimately, we identified five genes (<i>PLAC8, IL4I1, ZNF80, CCR8, CLEC4C</i>) as novel prognostic markers for SKCM. Furthermore, multivariate Cox analyses pinpointed <i>ZNF80</i> and <i>CCR8</i> as independent prognostic biomarkers. Experimental validation targeting these genes revealed significant downregulation in melanoma cells, except for <i>CCR8</i>. Subsequent knockdown of <i>IL4I1</i> promoted both the proliferation and inhibited the apoptosis of melanoma cells.</p><p><strong>Conclusion: </strong>In summary, our study identified a series of potential prognostic genes in melanoma and verified the functional role of <i>IL4I1</i> among them.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2615-2625"},"PeriodicalIF":1.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11586483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142715432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Effects of Rheumatoid Arthritis, Ankylosing Spondylitis, Juvenile Idiopathic Arthritis on Psoriasis: A Mendelian Randomization Study.","authors":"Yongping Cao, Mengyun Zhou, Tianhong Xu","doi":"10.2147/CCID.S490250","DOIUrl":"10.2147/CCID.S490250","url":null,"abstract":"<p><strong>Background: </strong>It is well-documented that rheumatoid arthritis (RA), ankylosing spondylitis (AS), and juvenile idiopathic arthritis (JIA) often exhibit skin manifestations, with psoriasis typically occurring around the time of diagnosis. Thus, it is essential to investigate the potential causal relationship between these forms of arthritis and psoriasis.</p><p><strong>Methods: </strong>The OpenGWAS provided traitIDs for exposure factors (RA (bbj-A-74), AS (ebi-A-GCST005529), and JIA (finn-b-JUVEN-ARTHR)) and outcome (psoriasis, finn-b-L12-PSORIASIS). bbj-A-74 had 19,190 samples (9,739,303 SNPs), ebi-A-GCST005529 had 22,647 samples (99,962 SNPs), finn-b-JUVEN-ARTHR had 173,622 samples (16,380,296 SNPs), and psoriasis had 216,752 samples (16,380,464 SNPs). Initially, 57 RA SNPs, 25 AS SNPs, and 5 JIA SNPs were acquired. Causal links were explored via univariate Mendelian Randomization (UVMR) analysis, with sensitivity analyses ensuring reliability. Additionally, multivariate MR (MVMR) analysis was conducted to further estimate the effect of each exposure factor on psoriasis.</p><p><strong>Results: </strong>Significant causal links (P < 0.05, OR > 1) were found between bbj-A-74, ebi-A-GCST005529, finn-b-JUVEN-ARTHR, and finn-b-L12-PSORIASIS, indicating associations of RA, AS, and JIA with psoriasis. Sensitivity analyses ensured the reliability of these finding, showing no heterogeneity, horizontal pleiotropy, or SNP locus oversensitivity in UVMR results. Furthermore, MVMR analysis revealed AS and JIA as psoriasis risk factors, while RA showed non-significant protective effects. This suggests AS and JIA may contribute to psoriasis onset or exacerbation when coexisting.</p><p><strong>Conclusion: </strong>MR analyses were conducted to investigate the causal links between RA, AS, JIA, and psoriasis, enhancing our grasp of the underlying mechanisms of psoriasis.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2583-2593"},"PeriodicalIF":1.9,"publicationDate":"2024-11-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11585978/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142709370","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pulsed Dye Laser for Port Wine Stains in 974 Children: A 20-Year Study in China.","authors":"Bingyu Xiu, Zhe Xu, Zigang Xu, Bin Zhang, Li Wei, Lin Ma","doi":"10.2147/CCID.S487229","DOIUrl":"10.2147/CCID.S487229","url":null,"abstract":"<p><strong>Importance: </strong>Port-wine stain (PWS) is a congenital vascular condition involving dilation of skin capillaries and venules, significantly affecting patients' physical and mental health. Pulsed dye laser (PDL) is widely used for PWS treatment; however, large-scale data on pediatric cases remain limited. This retrospective study aims to investigate the efficacy of laser treatment and its related factors in a large sample.</p><p><strong>Objective: </strong>To assess the clinical efficacy and adverse reactions of 595nm PDL for treating pediatric PWS and to identify factors influencing treatment outcomes.</p><p><strong>Methods: </strong>This retrospective study included 974 pediatric patients with PWS treated at Beijing Children's Hospital from 2003 to 2021. Inclusion criteria required patients to be under 18, with solitary PWS and Fitzpatrick skin types II-IV. Treatment efficacy was evaluated using standardized photographs taken before and after treatment, with outcomes categorized by Achauer's clearance criteria. Ridit analysis assessed the impact of variables such as gender, age, lesion location, and treatment frequency on outcomes.</p><p><strong>Results: </strong>The overall efficacy rate was 65.3%, higher in females (69.7%) than males (59.7%). Adolescents had the highest efficacy (100%) due to better compliance. Limb lesions responded best (87.5%), followed by neck (75.0%), trunk (66.7%), and head/face (63.0%). Smaller lesions (≤3 cm²) achieved 76.8% efficacy. Efficacy rose with sessions, reaching 84.0% after three. The mandibular branch (V3) had the highest trigeminal efficacy (68.5%). Adverse reactions (4.31%) included pigmentation changes (2.87%), hypopigmentation (1.03%), and minimal scarring (0.41%).</p><p><strong>Conclusion: </strong>The efficacy of 595nm PDL for treating PWS in children is influenced by gender, age, lesion location, size, and the number of treatment sessions. PDL is an effective treatment for pediatric PWS with minimal adverse reactions.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"17 ","pages":"2573-2581"},"PeriodicalIF":1.9,"publicationDate":"2024-11-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11572471/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142666333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}