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IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-03-13 eCollection Date: 2025-01-01 DOI:10.2147/CCID.S484813

Jian Chen, Dan Jian, Bingxue Bai

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引用次数: 0

摘要

背景：以往的研究表明，代谢物（尤其是脂质相关代谢物）对特应性皮炎（AD）的发病有重要影响。然而，没有证据表明代谢物与特应性皮炎风险之间存在因果关系。具体机制需要进一步阐明。我们的研究采用了双样本孟德尔随机化（TSMR）策略来研究代谢物特质如何影响过敏性皮炎：利用公开的 GWAS 数据，我们进行了 TSMR 研究，以调查 233 个代谢物性状（213 个脂质相关性状和 20 个非脂质相关性状）与 AD 之间的关系。我们的 TSMR 研究主要采用逆方差加权法和四种辅助方法来分析因果关系。为了保证 TSMR 结果的可信度，我们进行了敏感性分析。反向 MR 分析用于研究反向因果关系：对代谢物和 AD 的 GWAS 数据集进行分析后，发现 13 种代谢物呈阳性。乳糜微粒和超大型 VLDL 中的甘油三酯含量、乳糜微粒和超大型 VLDL 中的总脂质含量、乳糜微粒和超大型 VLDL 中的磷脂含量、中型 LDL 中的磷脂含量、大型 LDL 中的磷脂含量、小型 LDL 中的磷脂含量、18：亚油酸与总脂肪酸之比为 18:2 时，对注意力缺失症有负面影响。反向磁共振结果分析发现，AD 患者血清中 18:2 亚油酸与总脂肪酸之比降低。敏感性分析确保了我们结果的稳定性：这些研究结果突显了代谢物与AD之间的明确相关性，证明了13种脂质相关代谢物特征的重要作用。我们的研究结果大大减少了不可避免的混杂因素和反向因果关系的影响。我们的研究结果可为前瞻性治疗方法设定框架，并需要进一步调查验证。

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The Causal Relationship Between Circulating Metabolites and the Risk of Atopic Dermatitis: A Two-Sample Mendelian Randomization Study.

Background: Previous research has shown that metabolites (especially lipid-related metabolites) have a significant influence in the development of atopic dermatitis (AD). However, there is no evidence of a causal connection between metabolites and AD risk. The specific mechanisms require further elucidation. Our study employed a two-sample Mendelian randomization (TSMR) strategy to investigate how metabolite traits affect AD.

Methods: Utilizing publicly accessible GWAS data, we conducted TSMR studies to investigate the relationship between 233 metabolites traits (213 lipid-related traits and 20 no lipid-related traits) and AD. Our TSMR study primarily employed the Inverse-variance weighted method and four ancillary methods to analyze causation. Sensitivity analysis was performed to guarantee the TSMR results were trustworthy. Reverse MR analysis was used for investigating reverse causality.

Results: After analyzing GWAS datasets for metabolites and AD, 13 metabolites were identified as positive. The MR analysis result indicates that total cholesterol in very small VLDL, cholesterol esters in very small VLDL, free cholesterol in IDL, concentration of medium LDL particles, concentration of large LDL particle, concentration of chylomicrons and extremely large VLDL particles, triglyceride levels in chylomicrons and extremely large VLDL, total lipid levels in chylomicrons and extremely large VLD, phospholipid levels in chylomicrons and extremely large VLDL, phospholipids in medium LDL, phospholipids in large LDL, phospholipids in small LDL, ratio of 18:2 linoleic acid to total fatty acids exhibited negative effects on AD. Reverse MR result analysis found that ratio of 18:2 linoleic acid to total fatty acids in serum was decreased in patients with AD. Sensitivity analyses ensure the stability of our results.

Conclusion: These findings highlight a definite correlation between metabolite and AD, demonstrating the significant role of 13 lipid-related metabolite traits. Our results significantly reduced the influence of unavoidable confounders and reverse causality. Our findings may set the framework for prospective therapeutic approaches and call for further investigation to validate them.

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.