Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Anatomy-Driven Aesthetic Design for Facial Contouring in Northeast Asian Females: A Conceptual Framework and Case Report.","authors":"Sungjoo Kwon","doi":"10.2147/CCID.S606211","DOIUrl":"https://doi.org/10.2147/CCID.S606211","url":null,"abstract":"<p><p>Facial filler contouring is commonly planned within a volume-centric framework emphasizing product selection and localized augmentation. Although widely used, such approaches may not always clearly separate material selection from aesthetic design intent or fully incorporate population-specific anatomical characteristics, particularly in Northeast Asian faces. This proof-of-concept case report proposes an anatomy-informed, design-oriented conceptual framework that prioritizes whole-face contour continuity and anatomically appropriate pathways over isolated volumetric correction. A population-contextualized Reference Facial Form is introduced as a qualitative design reference from which aesthetic intent is translated into geometric principles and subsequently into predefined vectors. In this framework, vectors are structured cannula-based trajectories defined by specific entry points, advancement directions, withdrawal pathways, and deep anatomical planes. Procedural planning is guided by predefined procedural conditions-including anatomical entry points, vector orientation, and relative filler distribution within deep planes-rather than primarily by fixed injection volumes. The framework is illustrated through a single two-stage clinical case. The initial stage used an off-label diluted polycaprolactone-based admixture to establish broad deep-plane structural support, followed by selective contour refinement with hyaluronic acid fillers after initial stabilization. Early clinical images illustrated the correspondence between the planned vectors and early contour formation but were not suitable for establishing treatment efficacy or durability. The available follow-up was also insufficient to establish long-term safety. Fifteen de-identified supplementary cases constituted a criterion-defined consecutive illustrative series demonstrating recurrent vector and entry-point patterns across similar anatomical contexts; they were not analyzed as a validation or outcome cohort. By framing facial filler contouring as a design-first process, this framework may provide a conceptual language for clinical planning and education. Its clinical efficacy, inter-operator reproducibility, generalizability, and long-term safety require evaluation in larger, systematically designed studies.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"606211"},"PeriodicalIF":2.5,"publicationDate":"2026-09-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13580454/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multimodal Abdominal Contouring Combining Injectable Lipolysis, Ultrasonic Cavitation, and Neuromuscular Electrical Stimulation: A Retrospective Case Series.","authors":"Antony de Paula Barbosa","doi":"10.2147/CCID.S644120","DOIUrl":"10.2147/CCID.S644120","url":null,"abstract":"<p><p>Abdominal contouring has progressively evolved from isolated fat reduction techniques toward multimodal approaches that simultaneously address adipose tissue, muscular definition, and body composition. This retrospective case series describes preliminary clinical observations in five physically active patients with persistent localized abdominal adiposity despite regular resistance training, adherence to a low-carbohydrate diet, and protein supplementation. All patients underwent a standardized six-month multimodal protocol consisting of two sequential phases. The first phase combined injectable lipolysis using sodium deoxycholate, pentoxifylline, and L-carnitine with ultrasonic cavitation (Mesolipo). The second phase (Abdomen Definition) comprised targeted subcutaneous injections intended to enhance abdominal grooves, intramuscular metabolic support of the rectus abdominis, and neuromuscular electrical stimulation using Russian current. Treatment outcomes were assessed through standardized clinical photography, anthropometric measurements, and multifrequency bioimpedance analysis before and after completion of the protocol. Descriptive pre- and post-treatment comparisons showed reductions in median abdominal circumference from 94 to 88 cm, body fat percentage from 13.7% to 10.3%, fat mass from 11.3 to 8.7 kg, and abdominal skinfold thickness from 22 to 16 mm. Skeletal muscle mass was preserved or increased in most patients, while standardized photographs showed visually apparent changes in abdominal contour and definition, including greater visibility of the rectus abdominis, linea alba, and semilunar lines. In several cases, changes in body composition were observed despite minimal variation or slight increases in total body weight, a pattern compatible with body recomposition rather than weight loss alone. Given the retrospective, uncontrolled design, the small sample size, and the simultaneous use of multiple interventions, these observations cannot establish treatment efficacy or determine the relative contribution of individual protocol components, resistance training, or nutritional habits. Nevertheless, the findings provide preliminary, descriptive, and hypothesis-generating observations regarding the feasibility of a multimodal approach to abdominal contouring. Prospective controlled studies with larger samples are needed to evaluate efficacy and determine the contribution of individual therapeutic components.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"644120"},"PeriodicalIF":2.5,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13572039/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148966948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"ATriple Comparative Study for Burn Wound Healing: Standard Treatment vs Quantum-Smart Proteins vs Laser-Activated QSPs Using in silico Simulation.","authors":"Khalid A Alfaifi","doi":"10.2147/CCID.S552824","DOIUrl":"10.2147/CCID.S552824","url":null,"abstract":"<p><p>Burn injuries remain a major clinical challenge due to delayed healing, infection risk, and fibrosis. This study employed in silico simulations to compare three therapeutic strategies: (1) silver sulfadiazine (standard care), (2) Quantum-Smart Proteins (QSPs) designed using AI and structural modeling, and (3) QSPs combined with Low-Level Laser Therapy (LLLT, 808 nm, 2 J/cm²). Simulated outcomes over 21 days included re-epithelialization, fibrosis, angiogenesis, and tissue biomechanics. Results indicated that QSPs improved wound healing compared to standard care, with the QSP+LLLT group showing the most favorable outcomes. These findings are preliminary and computational in nature but highlight QSPs as a promising avenue for regenerative therapeutics that warrants experimental validation. All findings in this study represent computational predictions only and have not been experimentally validated.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"552824"},"PeriodicalIF":2.5,"publicationDate":"2026-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13571634/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148963010","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ex vivo Evaluation of Live-MB2 and CX-2 Biotic Strains on Inflammatory and Barrier-Related Biomarkers in a Human Skin Atopic Dermatitis-Like Model.","authors":"Sejin Cheon, Haeun Lee, Da Yeong Nam, Seokjun Kim, Kyeongeun Kim, Jaeyu Park, Dong-Geol Lee, Chun Ho Park, So Min Kang, Young Mok Heo, Hyun Ho Han, Dong Keon Yon","doi":"10.2147/CCID.S630833","DOIUrl":"10.2147/CCID.S630833","url":null,"abstract":"<p><strong>Objective: </strong>Atopic dermatitis (AD) is a chronic inflammatory skin condition characterized by epidermal barrier disruption and immune dysregulation. Live-MB2 and CX-2 were used in an ex vivo human skin AD-like model, which provides a biologically relevant platform for assessing cosmetic ingredients targeting AD-like features.</p><p><strong>Methods: </strong>An AD-like condition was induced in ex vivo human skin explants by repeated tape stripping followed by 2,4-dinitrochlorobenzene stimulation. Skin tissues were treated with Live-MB2 or CX-2 via topical or dermal exposure. Epidermal thickness, IgE, and filaggrin levels were evaluated using hematoxylin and eosin, immunofluorescence, and Enzyme-Linked Immunosorbent Assay analyses.</p><p><strong>Results: </strong>Topical application of Live-MB2 and CX-2 significantly reduced epidermal thickness compared with AD-induced controls. IgE levels were significantly reduced, while filaggrin expression indicated a marked increase, indicating barrier recovery. No treatment-related tissue damage was observed.</p><p><strong>Conclusion: </strong>Live-MB2 and CX-2 showed favorable effects on inflammatory and barrier-related parameters in an ex vivo human skin AD-like model, supporting their potential application as cosmetic ingredients for sensitive and atopic-prone skin.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"630833"},"PeriodicalIF":2.5,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570615/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Short-Term Outcomes of an Investigational Hybrid Polymer-Hyaluronic Acid Filler for Nonsurgical Rhinoplasty: An Uncontrolled Pilot Study.","authors":"Hsin-Kai Chen, Hsi-Cheng Liu, Heng-Ju Lin, Donghui Wu","doi":"10.2147/CCID.S635669","DOIUrl":"10.2147/CCID.S635669","url":null,"abstract":"<p><strong>Background: </strong>Nonsurgical rhinoplasty using hyaluronic acid fillers provides minimally invasive correction of selected nasal contour irregularities. Hybrid formulations incorporating biodegradable polymeric microspheres have been developed to provide immediate volumetric correction together with additional structural support; however, clinical evidence regarding these formulations remains limited.</p><p><strong>Objective: </strong>To evaluate the short-term safety, tolerability, preliminary aesthetic effectiveness, and patient satisfaction associated with an investigational hybrid filler containing cross-linked hyaluronic acid, polycaprolactone, and polylactic acid microspheres.</p><p><strong>Methods: </strong>This prospective, single-center, uncontrolled pilot study included 150 adults undergoing nonsurgical rhinoplasty. Participants were assessed at baseline, Day 2, Week 2, Month 1, and Month 3. Outcomes included treatment-emergent adverse events, Global Aesthetic Improvement Scale ratings, patient satisfaction, nasal tip projection, dorsal height, and procedural characteristics.</p><p><strong>Results: </strong>Improved or Very Improved GAIS ratings were observed in 86.7% of participants at Month 1 and 83.3% at Month 3. Satisfaction scores of 4-5 were reported by 90.0% at Month 1 and 86.7% at Month 3. Tip projection increased by more than 1.5 mm in 70.0%, while dorsal height increased by more than 2.0 mm in 63.3%. Mild events included transient erythema in 3.3%, minor bruising in 13.3%, and injection-site pain with a VAS score greater than 5 in 10.0%. No serious or treatment-requiring adverse event, vascular compromise, skin necrosis, visual disturbance, infection, granuloma, delayed inflammatory reaction, or filler migration was observed during three months of follow-up.</p><p><strong>Conclusion: </strong>The investigational formulation demonstrated favorable short-term tolerability and early aesthetic improvement in an uncontrolled pilot setting. These findings do not establish comparative effectiveness, long-term durability, tissue integration, or long-term biocompatibility. Controlled studies with extended follow-up are required.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"635669"},"PeriodicalIF":2.5,"publicationDate":"2026-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13570612/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148954994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Lip Complexity Classification (LCC): A Proposed Framework Integrating Anatomical Assessment with Therapeutic Decision-Making in Lip Augmentation.","authors":"Elena Caride Miana","doi":"10.2147/CCID.S634221","DOIUrl":"10.2147/CCID.S634221","url":null,"abstract":"<p><strong>Background: </strong>Lip augmentation with hyaluronic acid (HA) fillers remains one of the most technically demanding procedures in aesthetic medicine due to the complex interaction between anatomical variability, tissue quality, dynamic muscular activity, aging-related changes, and previous aesthetic interventions. Although several assessment tools exist for evaluating lip volume, there is currently no standardized system designed to stratify lip treatment complexity and guide therapeutic decision-making. This study proposes the Lip Complexity Classification (LCC), a novel framework intended to correlate anatomical complexity with treatment objectives and injection strategies.</p><p><strong>Methods: </strong>A conceptual classification system was developed based on anatomical principles and clinical experience. The LCC integrates five key assessment domains: relative lip volume, shape and symmetry, signs of perioral aging, tissue quality, and history of previous treatments. Patients are stratified into three complexity grades (Grade I-III) according to the highest-complexity criterion identified during clinical assessment. For each grade, specific therapeutic objectives, proposed treatment strategies, and technique-oriented approaches were defined.</p><p><strong>Results: </strong>The proposed classification distinguishes three progressively complex clinical scenarios. Grade I (low complexity) is characterized by preserved anatomy and is primarily managed through compartment-based volumization strategies. Grade II (moderate complexity) includes early structural deterioration, mild asymmetry, or functional imbalance, requiring combined restoration of lip architecture and selective treatment of adjacent perioral structures. Grade III (high complexity) encompasses advanced anatomical deterioration, significant tissue compromise, and sequelae of previous aesthetic treatments, frequently requiring multilayer lip and perioral rehabilitation. The framework establishes a direct relationship between complexity grade, therapeutic objectives, anatomical targets, product selection, injection depth, and technical approach.</p><p><strong>Conclusion: </strong>The Lip Complexity Classification (LCC) provides a structured, multidimensional framework for assessing lip treatment complexity beyond lip volume alone. As a conceptual framework requiring further validation, the LCC may support treatment planning, procedural standardization, and medical education, while providing a basis for future integration with AI-assisted assessment, non-invasive imaging, and multimodal treatment strategies. Its reliability, validity, clinical utility, safety, and potential impact on treatment outcomes and procedural standardization remain to be established. Prospective studies are required to establish its reproducibility and clinical utility before routine implementation in clinical decision-making.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"634221"},"PeriodicalIF":2.5,"publicationDate":"2026-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13565382/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148955028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Multiorgan Complications of Stevens-Johnson Syndrome and Toxic Epidermal Necrolysis: A Systematic Review.","authors":"Chaerani Pratiwi Firdaus, Reiva Farah Dwiyana, Laila Tsaqilah, Endang Sutedja, Oki Suwarsa, Miranti Pangastuti, Erda Avriyanti, Devina Gracia Pratama","doi":"10.2147/CCID.S626838","DOIUrl":"10.2147/CCID.S626838","url":null,"abstract":"<p><p>Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are acute, life-threatening mucocutaneous reactions causing necrosis of external and internal body surfaces, thereby predisposing patients to multiorgan complications. Numerous internal organ systems are impacted by SJS-TEN, encompassing the skin, ocular, ear, nose, and throat (ENT), pulmonary, gastrointestinal (GIT), and genitourinary systems. The acute and long-term organ complications associated with SJS-TEN have not been comprehensively documented. The objective of this review is to systematically delineate multiorgan complications in cases of SJS-TEN. A comprehensive search of the available literature was conducted on electronic databases (PubMed and Scopus) published between 2019 and 2024, reporting SJS-TEN patients with multiorgan complications using predefined search terms and inclusion/exclusion criteria. The terms \"Stevens-Johnson syndrome\", \"toxic epidermal necrolysis\", \"organ complication\", \"multiorgan involvement\", and \"sequelae\" were used as keywords. We included 38 articles reporting SJS-TEN patients with multiorgan complications, comprising 15 reviews, 11 original studies, 9 case reports, and 3 case series; data were synthesized descriptively, and no quantitative meta-analysis was performed. Reported percentages therefore reflect the proportion of included studies reporting a given complication, not patient-level prevalence. Among studies providing extractable patient-level data, the mean age of the subject population was 36.72 ± 26.58 years, with female predominance (88.2%). Ocular involvement was the complication most frequently reported across the included studies (65.8% of studies), followed by pulmonary and genitourinary involvement (26.32% of studies each) and skin complications (21.05% of studies). The most frequently reported ocular complications were trichiasis, distichiasis, and symblepharon, each noted in 60% of studies reporting ocular involvement. SJS-TEN represents a severe delayed-type hypersensitivity reaction with a high risk of long-term mucocutaneous disabling effects. Given the heterogeneity of the included study designs, these findings should be interpreted as an indication of how frequently each complication has been reported in the literature rather than as an estimate of true patient-level risk. This systematic review emphasizes the importance of clinician awareness to ensure early detection of multiorgan complications associated with SJS-TEN, thereby ensuring optimal, multidisciplinary patient management.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"626838"},"PeriodicalIF":2.5,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148918663","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Palmoplantar Keratoderma: A Mechanism-Based Disease Classification.","authors":"Jia-Wei Liu, Xiaerbati Habulieti, Yue-Tong Qian, Xiao Ma, Yangyang Han, Dong-Lai Ma","doi":"10.2147/CCID.S613425","DOIUrl":"10.2147/CCID.S613425","url":null,"abstract":"<p><strong>Background: </strong>Palmoplantar keratoderma (PPK) represents a diagnostically challenging group of genodermatoses due to its extensive genetic heterogeneity. Although multiple causative genes have been identified, the clinical utility of these discoveries remains limited, because few studies directly compare how distinct molecular mechanisms translate into divergent clinical phenotypes.</p><p><strong>Methods: </strong>We describe and analyze three paradigmatic PPK cases with genetically confirmed diagnoses involving <i>SERPINB7</i>-related Nagashima-type PPK, <i>TRPV3</i>-related Olmsted spectrum disorder, and <i>KRT1</i>-associated PPK. Clinical features, disease severity, and genetic mutations were systematically compared. These observations generated a novel classification framework and were then integrated with a comprehensive review of contemporary literature to contextualize and support the comparative findings.</p><p><strong>Results: </strong>Three patients with palmoplantar keratoderma (PPK) harboring distinct pathogenic variants were analyzed and comparatively evaluated. Despite overlapping clinical features, these cases corresponded to three distinct pathogenic mechanisms: defective barrier homeostasis, overactive signaling, and structural collapse. A mechanism-based classification framework was established accordingly. Through comprehensive literature review, 56 PPK-associated genes were identified, the majority of which could be systematically assigned to the three mechanistic categories based on their primary molecular functions.</p><p><strong>Conclusion: </strong>This study highlights that clinically overlapping PPK phenotypes arise from distinct molecular mechanisms. Our mechanism-based classification provides a framework linking genotype to pathogenesis, which may improve diagnostic precision, support the development of mechanism-targeted therapeutic strategies, and thereby advancing personalized management in hereditary PPK.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"613425"},"PeriodicalIF":2.5,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13559880/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148944360","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Burdens of Malignant Melanoma and Projections for 2050 in Asia: Findings from the 2023 Global Burden of Disease Study.","authors":"Chaochao Lu, Chenchang He, Guofang Wang, Shuo Zhao, Heling Huang","doi":"10.2147/CCID.S629052","DOIUrl":"10.2147/CCID.S629052","url":null,"abstract":"<p><strong>Background: </strong>Malignant melanoma(MM) is a significant global health concern, with increasing incidence worldwide. However, comprehensive assessments of its burden in Asia remain limited.</p><p><strong>Methods: </strong>Based on the Global Burden of Disease Study (GBD) data for 2023, an analysis was conducted on the disease burden of MM across 48 countries in Asia from 1990 to 2023. The trends in the disease burden of MM were assessed using the Estimated Annual Percentage Change (EAPC). Furthermore, the Bayesian Age-Period-Cohort (BAPC) model was employed to predict the future burden of MM to 2050.</p><p><strong>Results: </strong>From 1990 to 2023, age-standardized incidence rates (ASIR) increased across most of Asia, with the most pronounced positive EAPC values observed in low- and middle-SDI regions. In contrast, high-SDI areas exhibited stable incidence rates but declining mortality and disability-adjusted life year (DALY) rates. The epicenter of the burden shifted from affluent nations to rapidly developing economies; by 2023, East Asia reported the highest absolute case numbers and prevalence. The age distribution has shifted from the 45-64 age group to those aged 65 years and older, with individuals aged 75 and above dominating both prevalence and mortality rates in East Asia. Key drivers of these trends include cumulative UV exposure, lifestyle changes, and disparities in diagnosis and treatment. The BAPC forecasts for East Asia from 2024 to 2050 predict continued increases in ASIR and prevalence, stabilization of mortality rates, and modest declines in DALYs; however, uncertainty intervals widen as the forecast horizon extends.</p><p><strong>Conclusion: </strong>Asia faces a dual challenge: rising incidence and a progressive eastward/southward burden shift to lower‑SDI countries. Effective responses require equitable, context‑specific strategies combining sun‑safety campaigns, early detection, advanced diagnostics, and affordable treatments across socioeconomic strata. Strengthening prevention, healthcare infrastructure, and surveillance is essential to reduce the long‑term human and economic impact of melanoma in the region.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"629052"},"PeriodicalIF":2.5,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557228/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148918613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Moulin's Linear Atrophoderma: Two Case Reports and Literature Review.","authors":"Jiaxin Meng, Lingzhu Liao, Shi Wu, Yong He, Yunfeng Hu, Saijun Liu","doi":"10.2147/CCID.S592349","DOIUrl":"10.2147/CCID.S592349","url":null,"abstract":"<p><p>Moulin's linear atrophoderma (LAM) is a rare acquired pigmentary atrophic dermatosis distributed along Blaschko's lines, with an unclear etiology and poorly understood pathogenesis. This report presents two cases of LAM. Both patients were male, with onset during adolescence. Notably, one patient exhibited elevated antinuclear antibody (ANA) levels (1:320). Histopathological examination of both cases revealed a generally normal or mildly hyperplastic epidermis, hyperpigmentation of the basal layer, and a mixed inflammatory cell infiltrate (predominantly lymphocytes) in the dermis. Based on their clinical presentation and histopathological findings, both patients were diagnosed with LAM.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"592349"},"PeriodicalIF":2.5,"publicationDate":"2026-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13557156/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148918716","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}