Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"The Comparable Efficacy Between Tranexamic Acid Intradermal Injection and Pulsed Dye Laser for Treatment of Post-Acne Erythema: A Split-Face Therapy.","authors":"Kartika Ruchiatan, Gempita Nuzuliyah, Trustia Rizqandaru, Yuri Yogya, Diah Puspitosari, Miranti Pangastuti, Rafithia Anandita, Reti Hindritiani","doi":"10.2147/CCID.S538930","DOIUrl":"10.2147/CCID.S538930","url":null,"abstract":"<p><p>Post-acne erythema (PAE) is persistent erythema after acne vulgaris (AV) inflammatory lesions have resolved. Pulsed dye laser (PDL) is the gold standard for vascular lesions and is effective for PAE. Tranexamic acid (TA) can reduce vascular endothelial growth, angiogenesis, and inflammation by inhibiting plasminogen activity, and can be used in PAE treatment. This case report aim to compare the clinical efficacy of intradermal TA and PDL therapy using a split-face design in a 23-year-old female with moderate AV, post-inflammatory hyperpigmentation (PIH), and PEA. Dermatological examination revealed comedones, papules, pustules, nodules, hyperpigmented macules, boxcar scars, and erythematous macules overlying the post-acne atrophic scars. In addition to acne therapy, patient received intradermal TA (5 mg/mL) on the left face and PDL therapy on the right, respectively. Outcomes were assessed at day 7 and day 14. Parameters evaluated included acne lesion count, erythema index (a* value), and Dermatology Life Quality Index (DLQI). Both interventions led to a comparable result as such decreased a* value by 17.8% on the TA-treated side and 16% on the PDL-treated side. The DLQI score also improved. Both treatment modalities are effective for PAE and repeated sessions are necessary to achieve optimal results. Intradermal TA demonstrates comparable short-term efficacy to PDL in reducing PAE and may represent a safe, cost-effective alternative, particularly in resource-limited settings. Further studies with larger cohorts are needed to validate these findings.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2039-2046"},"PeriodicalIF":2.2,"publicationDate":"2025-08-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12401662/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Subcutaneous Panniculitis-Like T-Cell Lymphoma in Children: Two Case Reports.","authors":"Malgorzata Mitura-Lesiuk, Wiktora Sielwanowska, Maciej Dubaj, Mateusz Raniewicz, Karol Bigosinski","doi":"10.2147/CCID.S538418","DOIUrl":"10.2147/CCID.S538418","url":null,"abstract":"<p><p>Subcutaneous panniculitis-like T-cell lymphoma (SPTCL) is a rare primary cutaneous lymphoma derived from cytotoxic αβ T cells, clinically and histopathologically resembling inflammatory diseases of adipose tissue, particularly lupus panniculitis. It accounts for <1% of all non-Hodgkin's lymphomas, with approximately 20% of cases occurring in children. The main aim of this paper was to present two pediatric cases of SPTCL, highlighting the diagnostic challenges involved. The first patient, a 5-year-9-month-old boy, was admitted with a 15 cm infiltrative lesion on the left thigh, previously misdiagnosed and unsuccessfully treated with antibiotics. Imaging revealed an infiltrate resembling lymphedema. A biopsy confirmed SPTCL with a typical immunophenotype. The patient received EURO-LB 02 protocol therapy for peripheral T-cell lymphoma, complicated by pancytopenia, respiratory infection, and polyneuropathy. Post-treatment follow-up showed lesion regression, with residual subcutaneous atrophy (5 cm). The second patient, a 7-year-old girl, presented with a 10 cm inflammatory lesion on the left thigh and systemic symptoms. Imaging and histopathology confirmed the diagnosis. She was treated with the same protocol. Three years later, disease recurrence occurred on the left forearm, managed with alemtuzumab and methotrexate. Both patients remain under outpatient follow-up. Despite its rarity, SPTCL poses a significant diagnostic challenge in children. Accurate differentiation and early diagnosis are crucial for prompt and effective treatment.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2025-2033"},"PeriodicalIF":2.2,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144991325","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Skin Care Supports Overall Well-Being.","authors":"Tingting Zhu, Fumin Fang, Hao Li, Dongyun Lei, Mao-Qiang Man","doi":"10.2147/CCID.S539786","DOIUrl":"10.2147/CCID.S539786","url":null,"abstract":"<p><p>Skin is more than a physical barrier; it plays a crucial role in overall health, emotional well-being, and social interactions. Beyond its primary function in protection and sensation, the skin actively influences extracutaneous systems through immune regulation, endocrine signaling, and microbiome interactions. Dermatological conditions such as psoriasis, eczema, and rosacea are linked to systemic inflammation, cardiovascular risks, and metabolic disorders, demonstrating the skin's far-reaching impact on overall health. Additionally, skin appearance affects psychological health, self-esteem, and social engagement, reinforcing its significance beyond physiology. Maintaining skin integrity in aging populations may help mitigate the progression of systemic diseases associated with inflammation and aging. Enhancing epidermal function in neonates, particularly pre-term neonates, lowers the risk of infections and mortality rates, while promoting the weight gain. Understanding these broader influences of skin can lead to more holistic therapeutic strategies, emphasizing dermatological health as a component of overall well-being. This perspective explores the connection between the cutaneous and extracutaneous conditions, and highlights the importance of improvement of cutaneous conditions in the management of some health conditions.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2013-2023"},"PeriodicalIF":2.2,"publicationDate":"2025-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12399108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945451","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methotrexate-Induced Leukocytoclastic Vasculitis: A Case Report and Literature Review.","authors":"Yanisa Ratanapokasatit, Natthachat Jurairattanaporn","doi":"10.2147/CCID.S528734","DOIUrl":"10.2147/CCID.S528734","url":null,"abstract":"<p><p>Methotrexate (MTX) is widely utilized for the management of autoimmune diseases and neoplasms. It may cause several adverse effects, including myelosuppression, hepatitis, and mucositis, and in rare cases, can result in cutaneous vasculitis. We present a case involving a 60-year-old female patient receiving 5 milligrams (mg) of MTX weekly for the treatment of systemic lupus erythematosus (SLE). Her underlying condition was end-stage renal disease (ESRD), requiring hemodialysis (HD). Ten weeks after MTX treatment, she developed oral ulcers, pancytopenia, and hepatitis, followed by multiple non-blanchable erythematous papules, along with a few vesicles and pustules on the neck, trunk and arms. Laboratory results indicated elevated serum MTX levels, and skin biopsy demonstrated dense superficial perivascular and interstitial lymphocytic, eosinophilic, and neutrophilic infiltration, along with nuclear debris and extravasated erythrocytes, indicative of early leukocytoclastic vasculitis (LCV). Direct immunofluorescence (DIF) identified C3 deposits at the dermo-epidermal junction and superficial blood vessels, indicating possible immune complex-mediated vascular disease. The patient was diagnosed with MTX toxicity and histologically confirmed LCV secondary to MTX. MTX toxicity was effectively treated with intravenous folinic acid and cessation of MTX, alongside prescriptions of oral prednisolone and emollients for LCV management. Serum MTX levels became undetectable after a five-day treatment regimen. Skin lesion resolution occurred within one week. Additionally, a review of existing literatures on MTX-induced LCV was conducted.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2005-2012"},"PeriodicalIF":2.2,"publicationDate":"2025-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12393089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pancreatic Panniculitis Complicated by Asymptomatic Acute Pancreatitis with Biliary Stricture: Analysis of a Misdiagnosed Case.","authors":"Xiaofeng Chen, Zhuofu Luo, Jixiang Xu, Changqiang Li, Yang Xu","doi":"10.2147/CCID.S535196","DOIUrl":"10.2147/CCID.S535196","url":null,"abstract":"<p><p>This report describes a case of pancreatic panniculitis secondary to acute pancreatitis caused by biliary stricture following multiple biliary surgeries. The aim is to highlight the importance of recognizing atypical presentations. The patient, a 46-year-old woman, presented with erythematous macules and nodules on the extremities accompanied by polyarthralgia. She had a history of multiple biliary surgeries over the past decade. Histopathological examination of the skin lesions revealed no significant epidermal abnormalities but demonstrated perivascular neutrophilic infiltration in the dermis and subcutaneous fat, with evidence of adipocyte necrosis, calcification, and ghost cell formation. Laboratory findings indicated hyperamylasemia; however, the initial imaging did not suggest pancreatitis and there are no relevant clinical symptoms, which contributed to the misdiagnosis. This case underscores the need for heightened awareness of atypical clinical manifestations in pancreatic-related conditions.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1999-2003"},"PeriodicalIF":2.2,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12382976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945479","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research Hotspots in Natural Products for Wound Healing: A Bibliometric Analysis and Literature Review.","authors":"Fan Yang, Zhengyi Fang, Mengfan Yang, Zilin Cheng, Ye Tian, Jingni Liang, Tianhao Li","doi":"10.2147/CCID.S544826","DOIUrl":"10.2147/CCID.S544826","url":null,"abstract":"<p><strong>Purpose: </strong>Wound healing is a common chronic disease that has gradually become a significant healthcare burden. The therapeutic potential of natural products in modulating pathological wound healing mechanisms has attracted increasing attention in recent years. A new focus in the field of promoting wound healing has emerged through the study of the mechanism of action of herbs and their derivatives and the translation of the results. This study aims to analyze and summarize the current status, research trends, and hotspots in this field to provide reference and direction for future research.</p><p><strong>Methods: </strong>Literature related to wound healing and natural products in the Web of Science Core Collection was searched and collected. Bibliometric and visualization analyses were performed using Microsoft Excel 2021, bibliometric tools (VOSViewer, Citespace 6.3.R1, and bibliometrix R package), and R 4.3.2.</p><p><strong>Results: </strong>A total of 2394 publications were included in this study. The annual number of publications has increased in this field year by year. China is the most productive country. Egyptian Knowledge Bank is the most influential research organization in terms of research output. AKKOL EK and LEUNG PC are the most influential authors in this field. <i>JOURNAL OF ETHNOPHARMACOLOGY, MOLECULES, PHYTOTHERAPY RESEARCH</i> are the most influential journals. Initially, research was focused on keywords such as medicinal plants, oxidative stress, inflammation, antimicrobial activity, and apoptosis. In recent years, new research hotspots have emerged, including pyroptosis, ferroptosis, collagen deposition, and nanodrug delivery.</p><p><strong>Conclusion: </strong>The study of the relationship between natural products and wound healing has a promising future, and translational research targeting natural products will be the focus of future chronic wound therapy research.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1985-1997"},"PeriodicalIF":2.2,"publicationDate":"2025-08-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12380089/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945448","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial Intelligence and Large Language Models in the Fight Against Superficial Fungal Infections: Friend or Foe?","authors":"Aditya K Gupta, Vasiliki Economopoulos","doi":"10.2147/CCID.S522271","DOIUrl":"10.2147/CCID.S522271","url":null,"abstract":"<p><p>Superficial fungal infections can have significant physical and psychological consequences for affected patients. These painful infections have become more prevalent and the rise of antifungal resistant strains is of great concern. New tools in the fight against these infections are needed, especially in areas were appropriate dermatological care is lacking. Artificial intelligence (AI) offers a potential solution for these care gaps. AI's capabilities have been increasing in sophistication at an astonishing pace, with large language models (LLMs), such as ChatGPT (OpenAI), Claude (Anthropic) and Gemini (Google) being capable of generating detailed responses to complex problems as well as demonstrating reasoning type behaviour. AI is currently in use and being developed for use within the clinic as well as the laboratory, with the potential to significantly improve access to dermatological care and patient outcomes. However, understanding how these AI models work at a basic level is necessary for safe, effective and efficient use and application to the management of superficial fungal infections. In this review, we provide a high-level description of how these models work, discuss the potentials and pitfalls of AI and LLMs, as well as their applications and the current and future outlook for the field.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1959-1969"},"PeriodicalIF":2.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945324","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ellagic Acid Mediates the Delay of Dermal Fibroblast Senescence via CSNK2A1.","authors":"Ziwei Zhang, Pu Yang, Yang Sun, Xinhai Yu, Xiangyu Chen, Xiancheng Wang","doi":"10.2147/CCID.S523963","DOIUrl":"10.2147/CCID.S523963","url":null,"abstract":"<p><strong>Objective: </strong>This research seeks to explore the impact of Ellagic Acid (EA) on the aging process of human dermal fibroblasts Hs68 cells and to uncover the mechanisms involved.</p><p><strong>Methods: </strong>Senescence was induced in Hs68 cells with H₂O₂, followed by treatment with EA and CSNK2A1 inhibitor (Silmitasertib). Bioinformatics identified EA's downstream targets. Cell viability was assessed by MTT assays, and senescence markers (γH2AX, p16, p19, p53), CSNK2A1, Nrf2, and NF-κB p65 were analyzed by Western blot. Inflammatory cytokines (IL-6, TNF-α, IL-1β) and oxidative stress markers (SOD, MDA, GSH/GSSG) were measured. ROS levels were assessed by fluorescence staining, senescence by SA-β-gal staining, cell cycle by flow cytometry and apoptosis by TUNEL assay.</p><p><strong>Results: </strong>Senescent cells showed increased γH2AX, p16, p19, and p53 expression, with reduced viability. EA inhibited senescence in a dose-dependent manner, with cytotoxicity at 60 μM. EA upregulated CSNK2A1, decreased β-galactosidase activity, restored cell viability and cycle progression, and reduced apoptosis. EA alleviated oxidative stress by enhancing Nrf2 expression, reducing ROS and MDA, and increasing SOD and GSH/GSSG. Silmitasertib negated these effects. EA also reduced IL-6, TNF-α, and IL-1β, inhibiting NF-κB p65, with anti-inflammatory effects mediated by CSNK2A1.</p><p><strong>Conclusion: </strong>EA delays dermal fibroblast senescence by modulating CSNK2A1, mitigating oxidative stress and inflammation, and may serve as a potential therapeutic for aging and age-related diseases.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1971-1983"},"PeriodicalIF":2.2,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12375307/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tofacitinib as a Novel Therapeutic Option for Pemphigus Vulgaris: A Case Report and Mechanistic Insights.","authors":"Xiang Li, Juan Zhang, Lian Zhang, Hongzhi Gu, Zhifang Zhai, Mingwang Zhang","doi":"10.2147/CCID.S536993","DOIUrl":"10.2147/CCID.S536993","url":null,"abstract":"<p><p>Pemphigus vulgaris (PV), a life-threatening autoimmune blistering disorder mediated by pathogenic anti-desmoglein antibodies, manifests clinically with extensive cutaneous and mucosal vesicles, bullae, and erosions. While corticosteroids remain first-line therapy, a substantial subset of patients develop refractory disease requiring advanced therapies. Tofacitinib, an oral Janus kinase (JAK) 1/3 inhibitor, demonstrates broad immunomodulatory effects through interference with cytokine signaling pathways. We report the case of a 50-year-old male with recalcitrant PV who achieved sustained remission following adjunctive tofacitinib therapy. Combination therapy with tofacitinib (5 mg twice daily) and prednisone (60 mg/day) enabled successful corticosteroids withdrawal within 5 months, achieving complete clinical remission (PDAI=0) and serological improvement (Dsg1/Dsg3 antibodies reduced by 64.5%/75.8%). Longitudinal immunohistochemistry (IHC) revealed attenuated phospho-STAT3 and phospho-STAT6 in post-treatment lesional skin compared to baseline. Proteomic profiling of PV lesions (n=3) versus healthy controls (n=3) identified 198 differentially expressed proteins (fold change >1.5, p<0.05), with KEGG pathway analysis revealing predominant enrichment in JAK-STAT signaling, IL-17-mediated inflammation, and lymphocyte differentiation pathways. Independent validation in an expanded cohort (5 PV vs 5 controls) confirmed constitutive JAK-STAT hyperactivation: phospho-STAT3 (7.2±1.64 vs 1±0, p<0.001) and phospho-STAT6 (9.6±1.34 vs 1.2±0.45, p<0.001) were markedly elevated in untreated PV lesions. These findings posit tofacitinib as a promising steroid-sparing agent in PV management, potentially through multimodal inhibition of pathogenic cytokine networks. Large-scale randomized controlled trials are warranted to validate these observations.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1953-1958"},"PeriodicalIF":2.2,"publicationDate":"2025-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12372842/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144945473","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wound Infection After Keloid Excision and Adjuvant Radiotherapy: Two Case Reports and Literature Review.","authors":"Qinyuan Zhao, Yuyan Wang, Jinsheng Li, Chuanbo Liu","doi":"10.2147/CCID.S545846","DOIUrl":"10.2147/CCID.S545846","url":null,"abstract":"<p><strong>Introduction: </strong>The combination of surgical excision and adjuvant radiotherapy is widely accepted as one of the most effective treatments for keloids. Although wound infection following radiotherapy has been reported in several studies, no study has investigated how such infections are managed or whether they ultimately lead to keloid recurrence.</p><p><strong>Case reports: </strong>Two patients, one male with an anterior chest keloid and one female with a mons pubis keloid, underwent surgical excision followed by adjuvant radiotherapy (20 Gy in four fractions) at our institution. Both patients developed wound infections following combined therapy, both of which were successfully treated using a comprehensive protocol. This protocol involved wound drainage and debridement, antibiotic administration, and moist wound healing. Complete healing was achieved in both cases, with no recurrence observed during the 18-month follow-up period.</p><p><strong>Discussion: </strong>The possible causes of radiation-induced infection were analyzed, including radiation itself, atopic dermatitis and specific surgical areas (such as the mons pubis region). Our study successfully addressed wound infection by adopting an effective treatment protocol involving wound drainage and debridement, antibiotic administration, and moist wound healing. Although favorable results were obtained in the two keloid cases, optimizing radiotherapy in terms of radiation mode, dosage, fraction and timing is still necessary to reduce the incidence of radiation-induced wound infections.</p><p><strong>Conclusion: </strong>Neither of the two patients experienced keloid recurrence when treated with an effective therapy for wound infection. This result demonstrates that a favorable outcome can be achieved with the appropriate and timely treatment protocol, even if an infection occurs after radiotherapy. Further clinical studies and basic research are needed to investigate the underlying mechanisms of the favorable outcome following radiation-induced infections.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"1943-1951"},"PeriodicalIF":2.2,"publicationDate":"2025-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12358146/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144871791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}