Clinical, Cosmetic and Investigational Dermatology最新文献_第7页

Dosimetry Assessment of Potential Hazard from Visible Light, Especially Blue Light, Emitted by Screen of Devices in Daily Use.

IF 1.9 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-01-20 eCollection Date: 2025-01-01 DOI: 10.2147/CCID.S490977

Norramon Charoenpipatsin, Punyanut Yothachai, Nuttaporn Nuntawisuttiwong, Ornnicha Wongpraparut, Pranomkorn Choosri, Narumol Silpa-Archa

引用次数: 0

Exploring the Impact of Systemic Inflammatory Regulators on Rosacea Risk: A Bidirectional Mendelian Randomization Analysis.

IF 1.9 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-01-20 eCollection Date: 2025-01-01 DOI: 10.2147/CCID.S495773

Qiao Xue, Jian Peng Pan, Da Qian, Jie Ji, Lai Yi Fei, Sheng Yao, Xing Tan, Wen Ge Fan

{"title":"Exploring the Impact of Systemic Inflammatory Regulators on Rosacea Risk: A Bidirectional Mendelian Randomization Analysis.","authors":"Qiao Xue, Jian Peng Pan, Da Qian, Jie Ji, Lai Yi Fei, Sheng Yao, Xing Tan, Wen Ge Fan","doi":"10.2147/CCID.S495773","DOIUrl":"10.2147/CCID.S495773","url":null,"abstract":"Objective: Rosacea is a common chronic inflammatory disorder primarily affecting the face. While inflammatory factors are known to play a pivotal role in its pathogenesis, their causal relationship with rosacea remains unclear. This study employed a two-sample bidirectional Mendelian randomization (MR) analysis to investigate the causal links between systemic inflammatory regulators and rosacea.Methods: Data on 41 cytokines and growth factors were analyzed from a genome-wide association study (GWAS) meta-analysis involving 8293 individuals and genetic data from the FinnGen database, comprising 1195 rosacea cases and 211,139 controls. The principal inverse variance weighting (IVW) method was used to assess causal relationships, with sensitivity analyses, including heterogeneity and horizontal pleiotropy assessments, conducted to ensure result robustness.Results: MR analysis revealed that decreased expression of Stem Cell Factor (SCF), Macrophage Inflammatory Protein-1β (MIP-1β), and Monocyte Chemotactic Protein-1 (MCP-1) was associated with increased rosacea risk (OR = 1.54, 95% CI = 1.05-2.26, p = 0.026). Conversely, elevated expression levels of Stromal Cell-Derived Factor-1α (SDF-1α) and Hepatocyte Growth Factor (HGF) were linked to higher rosacea risk (OR = 1.61, 95% CI = 1.12-2.31, p = 0.009). Reverse MR analyses showed no significant impact of rosacea on systemic inflammatory regulator expression.Conclusion: This study identified five inflammatory factors-SCF, SDF-1α, MCP-1, HGF, and MIP-1β-as having causal relationships with rosacea pathogenesis. Further research is required to elucidate their mechanistic roles in disease development.","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"191-200"},"PeriodicalIF":1.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760274/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045784","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lymphomatoid Papulosis Type E With T-Cell Receptor Gamma Positivity.

IF 1.9 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-01-20 eCollection Date: 2025-01-01 DOI: 10.2147/CCID.S493027

Amornrut Namasondhi, Suthinee Rutnin, Suthep Jerasutus, Paisarn Boonsakan, Korn Triyangkulsri

{"title":"Lymphomatoid Papulosis Type E With T-Cell Receptor Gamma Positivity.","authors":"Amornrut Namasondhi, Suthinee Rutnin, Suthep Jerasutus, Paisarn Boonsakan, Korn Triyangkulsri","doi":"10.2147/CCID.S493027","DOIUrl":"10.2147/CCID.S493027","url":null,"abstract":"Lymphomatoid papulosis (LyP) is currently categorized as a primary lymphoproliferative disorder that follows a chronic, recurrent clinical course. The diagnosis of LyP is mainly based on clinical presentation and histopathological correlation. Six subtypes of LyP have been described and recognized, each with different histological features and sometimes distinct clinical presentations. LyP type E is a subtype that histologically shows angioinvasion and angiodestruction by CD8 and CD30-positive pleomorphic T cells. Clinically, it usually presents with a few large necrotic nodules or ulcers on the trunk or extremities, unlike other subtypes of LyP. Despite an indolent clinical course, long-term follow-up is necessary due to the risk of developing concurrent or secondary lymphoma. In this report, we demonstrate a case of lymphomatoid papulosis type E presented with widespread small papulonecrotic eruptions, an atypical clinical manifestation, and an unusual immunohistochemical profile. The biopsy revealed CD8, CD30, CD56, and TCR-γ-positive atypical lymphocytic infiltration with angioinvasion and angiodestruction. The patient was successfully treated with low-dose methotrexate.","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"177-182"},"PeriodicalIF":1.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758862/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045799","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Dermatologic Adverse Events Following Afatinib in a Woman with Non-Small-Cell Lung Cancer: A Case Report. 1例女性非小细胞肺癌患者服用阿法替尼后皮肤不良事件报告。

IF 1.9 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-01-17 eCollection Date: 2025-01-01 DOI: 10.2147/CCID.S490820

Laila Tsaqilah, Ananda Dwi Putri, Erda Avriyanti

{"title":"Dermatologic Adverse Events Following Afatinib in a Woman with Non-Small-Cell Lung Cancer: A Case Report.","authors":"Laila Tsaqilah, Ananda Dwi Putri, Erda Avriyanti","doi":"10.2147/CCID.S490820","DOIUrl":"10.2147/CCID.S490820","url":null,"abstract":"Epidermal growth factor receptor inhibitors (EGFRI) are biological factors used in several types of cancer, including non-small-cell lung cancers (NSCLC). One of the EGFR inhibitors that has been approved for NSCLC is afatinib. Dermatologic adverse events are the most commonly reported and may impair the patient's compliance to the therapy as it causes aesthetic discomfort and significantly impact the patient's quality of life. We report a case of 31-year-old woman diagnosed with stage IV-NSCLC and treated with afatinib since nine months prior to consult who presented with acneiform rash on the face, trunk, both arms and legs; pruritic pustules and waxy scales on the scalp; xerosis and pruritus of the skin; paronychia on both toes; hair changes on the scalp, eyebrows, eyelashes, and hypertrichosis of the face. Microscopic examination with Gram smear from periungual skin showed polymorphonuclear cells (PMNs) and Gram-positive cocci bacteria. Trichoscopy examination of the hair on the scalp revealed tapering hair, pili torti, follicular hyperkeratosis, multiple hair tufts with erythema, and scaling of the skin; the eyebrow and eyelashes revealed pili torti and tapering hair. The administration of afatinib was continued and the patient was treated with moisturizer, sunscreen, and mild cleanser, topical antibiotic, and topical steroid along with oral doxycycline and oral cetirizine for four weeks. Significant clinical improvement and Dermatology Life Quality Index (DLQI) score was seen on the fourth week of observation. Dermatological adverse events present the greatest concern with EGFRIs use because it can lead to infection, pain, depression, and low self-esteem, moreover, misdiagnosis may lead to treatment discontinuation. Recognizing clinical signs, implementing preventive efforts, and appropriate management are important to improve the quality of life and patient compliance for effective therapy of underlying malignancy.","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"151-159"},"PeriodicalIF":1.9,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748754/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Successful Treatment of Pediatric Generalized Pustular Psoriasis with Secukinumab. Secukinumab成功治疗小儿广泛性脓疱性银屑病

IF 1.9 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-01-16 eCollection Date: 2025-01-01 DOI: 10.2147/CCID.S493665

Keyi Yu, Huaye Bao, Xingang Wu

引用次数: 0

Cost Consciousness Among Dermatologists. 皮肤科医生的成本意识。

IF 1.9 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-01-16 eCollection Date: 2025-01-01 DOI: 10.2147/CCID.S476030

Mohammed A AlFada

{"title":"Cost Consciousness Among Dermatologists.","authors":"Mohammed A AlFada","doi":"10.2147/CCID.S476030","DOIUrl":"10.2147/CCID.S476030","url":null,"abstract":"Background: Physicians are responsible for most decisions related to resource allocation and healthcare expenditures, and should consider cost in their decision-making approach.Objective: To measure cost consciousness among dermatologists, evaluate their understanding of cost-related concepts, and explore what prevents them from factoring cost into their daily practice decisions.Methods: This cross-sectional survey-based study involved dermatologists from different practice types and work environments. The survey is split into four sections, focusing on participants' (1) demographic and workplace information; (2) knowledge of cost-related terms; (3) personal cost-consciousness level; and (4) perceived barriers to factoring cost into clinical decisions.Results: Overall, 132 practicing dermatologists participated in the survey. Approximately 82% of them had heard of cost-effectiveness, but only 10% really understood how to indicate, interpret, and calculate it, while most had never heard of cost-consciousness or cost-containment. The majority agreed that it is the responsibility of physicians to contain medication costs, and almost all agreed that physicians need to do more to limit the prescription of unnecessary medications. Sex, long work experience, mixed administrative and clinical roles, and working in a mixed practice setting were all associated with cost consciousness. Multivariate regression analysis showed a significant association between having a mixed clinical and administrative professional role and cost consciousness.Conclusion: Although most dermatologists agree that it is the responsibility of physicians to contain the cost when deciding on medication, they have limited understanding of cost-related concepts. Having a mixed clinical and administrative roles was a significant predictor of cost conscious behavior.","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"109-119"},"PeriodicalIF":1.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745169/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001432","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Clinical Epidemiology and Phenotypic Characteristics of Hidradenitis Suppurativa Disease in the Central Region of Saudi Arabia: Findings from a Cross-Sectional. 沙特阿拉伯中部地区化脓性汗腺炎的临床流行病学和表型特征：来自横断面的发现。

IF 1.9 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-01-16 eCollection Date: 2025-01-01 DOI: 10.2147/CCID.S493638

Hend Alotaibi, Abdulaziz Madani, Mohammed AlFada, Abdulrahman Alluhaybi, Turky Alsehli, Qais Almuhaideb, Sultan Alnasser, Abdulelah Aldossari, Maha Barakeh, Renad AlKanaan

{"title":"Clinical Epidemiology and Phenotypic Characteristics of Hidradenitis Suppurativa Disease in the Central Region of Saudi Arabia: Findings from a Cross-Sectional.","authors":"Hend Alotaibi, Abdulaziz Madani, Mohammed AlFada, Abdulrahman Alluhaybi, Turky Alsehli, Qais Almuhaideb, Sultan Alnasser, Abdulelah Aldossari, Maha Barakeh, Renad AlKanaan","doi":"10.2147/CCID.S493638","DOIUrl":"10.2147/CCID.S493638","url":null,"abstract":"Background: Hidradenitis suppurativa (HS) is a complex condition that is often misdiagnosed, and regional data on its clinical features and risk factors are limited. This study aimed to explore the clinical epidemiology and phenotypic characteristics of HS in the central region of Saudi Arabia.Materials and methods: A cross-sectional study was conducted on HS patients at King Khalid University Hospital (KKUH) in Riyadh from December 2020 to December 2021. Clinical, epidemiological, and comorbidity data were collected, and the severity of HS was categorized with the Hurley staging system. Statistical analysis was performed with SPSS, with the significance level set to p < 0.05.Results: Of the patients, 54.8% were aged 15-30 years, 57.04% were female, and 95.56% were Saudi. Obesity was present in 48.89% of the patients, and 34.07% were smokers. The comorbid conditions included acne (10.37%), asthma (8.15%), mental disorders (2.22%), and endocrine or noncommunicable diseases (18.52%). Most patients (80.74%) had multiple affected sites. No significant associations were found between these factors and HS severity (p > 0.05).Conclusion: In conclusion, HS primarily affects young, unmarried Saudi female patients, many of whom are smokers and have comorbid conditions such as asthma and skin disorders. Clinicians should carefully assess the risk profiles of patients, particularly those with smoking habits and comorbidities, and consider screening for HS in high-risk groups.","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"129-141"},"PeriodicalIF":1.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748051/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Misdiagnosis of Leprosy with Severe Reversal Reaction as Psoriatic Arthritis: A Case Report and Literature Review. 麻风病严重逆转反应误诊为银屑病关节炎1例报告并文献复习。

IF 1.9 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-01-16 eCollection Date: 2025-01-01 DOI: 10.2147/CCID.S502544

Hendra Gunawan, Risa Miliawati Nurul Hidayah, Kartika Ruchiatan, Miranti Pangastuti, Hermin Aminah Usman, Fatimah Amalia

{"title":"Misdiagnosis of Leprosy with Severe Reversal Reaction as Psoriatic Arthritis: A Case Report and Literature Review.","authors":"Hendra Gunawan, Risa Miliawati Nurul Hidayah, Kartika Ruchiatan, Miranti Pangastuti, Hermin Aminah Usman, Fatimah Amalia","doi":"10.2147/CCID.S502544","DOIUrl":"10.2147/CCID.S502544","url":null,"abstract":"Introduction: Leprosy is a chronic granulomatous disease caused by Mycobacterium leprae and Mycobacterium lepromatosis. Meanwhile, leprosy reactions are immunologically mediated episodes of acute or subacute inflammation that occur during the chronic course of the disease. Leprosy and leprosy reaction have a wide range of clinical manifestations, including those resembling psoriatic arthritis.Case presentation: A 30-year-old male was consulted by a rheumatologist with psoriatic arthritis and psoriasis vulgaris. History of recurrent painfully swollen fingers and multiple erythematous plaques covered with thick scales in the last two years was discovered. A physical examination revealed edema on the eyelids and all fingers of both hands and feet, accompanied by painful interphalangeal joints. There were anesthetic and hypoestetic erythematous plaques covered by thick scales on both upper and lower extremities and epigastric region. Non-tender enlargements with a rubbery consistency were found on the right great auricular nerve and both common peroneal nerves. Slit-skin smear examinations from anesthetic lesions on the left arm showed bacterial index 3+, and skin biopsies from anesthetic lesions on the left thigh revealed a granulomatous reaction with epithelioid cells, Langhans giant cells, and lymphocyte infiltration. The patient was diagnosed as mid-borderline leprosy with severe reversal reaction, then received multidrug therapy-multibacillary and prednisone. The improvement of skin lesions and fingers edema were found on the 40th day of observation.Conclusion: The varying symptoms of leprosy can lead to misdiagnosis. Proper training for healthcare professionals is crucial to ensure timely and accurate treatment.","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"121-128"},"PeriodicalIF":1.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11748035/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation Between the Koebner Phenomenon and Clinical Features in Vitiligo. 白癜风Koebner现象与临床特征的相关性研究。

IF 1.9 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-01-16 eCollection Date: 2025-01-01 DOI: 10.2147/CCID.S506426

Xianfa Tang, Cuilan Hao, Min Fan, Penghao Dong, Yinyin Qi, Jinping Gao, He Huang, Mengyun Chen, Wenjun Wang

{"title":"Correlation Between the Koebner Phenomenon and Clinical Features in Vitiligo.","authors":"Xianfa Tang, Cuilan Hao, Min Fan, Penghao Dong, Yinyin Qi, Jinping Gao, He Huang, Mengyun Chen, Wenjun Wang","doi":"10.2147/CCID.S506426","DOIUrl":"10.2147/CCID.S506426","url":null,"abstract":"Purpose: To investigate the correlation between the presence of the Koebner phenomenon (KP) and clinical features of patients with vitiligo.Patients and methods: The clinical characteristic data, including age, age of onset, disease duration, gender, clinical stage, clinical type, family history, and comorbid immune-related diseases, of 1472 patients with/without KP were analyzed with SPSS 17.0 software.Results: Of the 1472 patients, 290 (19.70%) were positive for KP. The clinical course (6.95 vs 5.62, P = 0.015), percentage of patients with progressive stage (78.97% vs 70.05%, P = 0.002), the acrofacial type (4.49% vs 1.69%, P = 0.004), comorbid immune-related diseases (28.29% vs 19.04%, P = 0.001) and lesion area ≥2% (47.24% vs 38.24%, P = 0.005) in KP-positive group were significantly greater than those in KP-negative group. Binary logistic regression analysis found that progressive stage (P = 0.003, OR = 1.60, 95% confidence interval (CI): 1.17-2.18), area of skin lesion ≥2% (P = 0.008, OR = 1.44, 95% CI: 1.10-1.88) and comorbid immune-related diseases (P = 0.001, OR = 1.63, 95% CI: 1.21-2.20) were significantly associated with KP.Conclusion: The presence of KP in patients with vitiligo is associated with clinical progression, the acrofacial type, comorbid immune-related disease and a larger lesion area. This study suggested the presence of KP may be an indicator of disease activity and aggression, and underlay its importance in the management of disease.","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"97-103"},"PeriodicalIF":1.9,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11745067/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Predictive Factors of Acne Scarring and Post-Inflammatory Hyperpigmentation: A Retrospective Cohort Study. 痤疮疤痕和炎症后色素沉着的预测因素：一项回顾性队列研究。

IF 1.9 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-01-15 eCollection Date: 2025-01-01 DOI: 10.2147/CCID.S504281

Awadh Alamri, Dhaii Alzahrani, Ghadi Alharbi, Rami Jan, Lulu Abdullah Alsubaie, Amjad Alghamdi, Amal H Abualola, Abdulhadi Jfri

{"title":"The Predictive Factors of Acne Scarring and Post-Inflammatory Hyperpigmentation: A Retrospective Cohort Study.","authors":"Awadh Alamri, Dhaii Alzahrani, Ghadi Alharbi, Rami Jan, Lulu Abdullah Alsubaie, Amjad Alghamdi, Amal H Abualola, Abdulhadi Jfri","doi":"10.2147/CCID.S504281","DOIUrl":"10.2147/CCID.S504281","url":null,"abstract":"Introduction: Acne vulgaris, a prevalent dermatological condition, often results in long-term complications such as scarring and hyperpigmentation. While extensive research has focused on treatment modalities, there is a notable gap in understanding the factors contributing to the development of acne scarring and post-inflammatory hyperpigmentation (PIH).Purpose: This study was conducted to identify the factors contributing to the development of acne scarring and post-inflammatory hyperpigmentation (PIH).Patients and methods: This retrospective cohort study, conducted at King Abdulaziz Medical City, Jeddah, Saudi Arabia, analyzed data from patients with acne vulgaris between 2016 and 2023 using the hospital's health information system, BESTCare. Statistical analysis was performed using RStudio (R version 4.3.1). We constructed a multivariable, multinomial logistic regression model to assess the independent predictors of four acne complication groups; no scarring/PIH, scarring alone, PIH alone, and acne scarring with PIH.Results: Among 417 analyzed participants, 95 participants had acne scarring (22.8%), 93 participants had PIH alone (22.3%), and 151 participants had both acne scarring with PIH (36.2%), and only 78 participants did not develop scarring or PIH (18.7%). Isotretinoin use and papules acne were associated with increased risk of acne complications. While adapalene gel was protective against acne scarring only.Conclusion: This retrospective study sheds light on factors influencing acne scarring and PIH among Acne Vulgaris patients. Our findings provide valuable insights for tailoring interventions and advancing our understanding of acne vulgaris complications in the future.","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"143-150"},"PeriodicalIF":1.9,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11742760/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143001398","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0