Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Low-Dose Corticosteroid Combined with Hydroxychloroquine for the Treatment of Generalized Annular Atrophic Lichen Planus: A Case Report.","authors":"Jinhui Xu, Li Chai","doi":"10.2147/CCID.S625316","DOIUrl":"10.2147/CCID.S625316","url":null,"abstract":"<p><strong>Purpose: </strong>Annular atrophic lichen planus (AALP) is a rare subtype of lichen planus. It is distinguished from other variants by the reduction of elastic fibers in the superficial dermis and the presence of annular skin lesions, which are characteristic features of this variant. AALP often exhibits a chronic course and poor response to treatment. The rare case presented here may provide valuable insights for dermatologists.</p><p><strong>Materials and methods: </strong>A case of a 57-year-old male diagnosed with generalized annular atrophic lichen planus is reported. Based on the clinical features and histopathological examination, a final diagnosis of generalized annular atrophic lichen planus was made. No significant abnormalities were found in the patient's baseline condition. Following the diagnosis of AALP, the patient was subjected to combination oral therapy with low-dose methylprednisolone (16 mg/day) and hydroxychloroquine (0.4 g/day).</p><p><strong>Results: </strong>A rapid resolution of the skin rash was observed two weeks after the initiation of treatment. During the clinical follow-up period of six months, no significant recurrence of the rash was noted.</p><p><strong>Conclusion: </strong>This case suggests that oral corticosteroids combined with hydroxychloroquine may be an effective treatment option for generalized annular atrophic lichen planus.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"625316"},"PeriodicalIF":2.5,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13594522/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cxcl9 as a Marker of Adipose Tissue Changes Caused by Bariatric Surgery and Psoriasis.","authors":"Zheng Zhou, Ling Kuang","doi":"10.2147/CCID.S640352","DOIUrl":"10.2147/CCID.S640352","url":null,"abstract":"<p><strong>Background: </strong>Bariatric surgery has been shown to improve psoriasis, but the underlying molecular mechanisms remain unclear. This study aimed to investigate shared molecular mechanisms between bariatric surgery-induced adipose changes and psoriasis using bioinformatics approaches.</p><p><strong>Methods: </strong>Transcriptomic data from adipose tissue before and after bariatric surgery and from psoriatic lesions were obtained from the GEO database. Common differentially expressed genes (co-DEGs) were identified and subjected to GO/KEGG enrichment analysis, protein-protein interaction network construction, and machine learning-based hub gene selection. Diagnostic performance and immune infiltration characteristics were evaluated.</p><p><strong>Results: </strong>Co-DEGs were significantly enriched in the IL-17 signaling pathway, defense response to bacterium, response to lipopolysaccharide, cytolysis, and collagen-containing extracellular matrix. CXCL9 was identified as a key hub gene via multiple machine learning algorithms, showing good diagnostic performance in external validation (AUC > 0.85). Immune infiltration analysis revealed that CXCL9 expression was positively correlated with M1 macrophage and CD8⁺ T cell abundance, and negatively correlated with M2 macrophages.</p><p><strong>Conclusion: </strong>CXCL9, through its involvement in the IL-17 signaling pathway and lipopolysaccharide response, may serve as a critical bridge linking adipose tissue inflammation and psoriatic skin immunity, providing a novel molecular target for the improvement of psoriasis following bariatric surgery.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"640352"},"PeriodicalIF":2.5,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13594523/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149023910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Transcriptomic and Machine Learning Analysis Identifies JAG1 and NR2F2 in Keloid.","authors":"Lingyi Yang, Wenshen Mo, Wendi Cao, Lin Mi, Xiaowei Wu","doi":"10.2147/CCID.S625100","DOIUrl":"10.2147/CCID.S625100","url":null,"abstract":"<p><strong>Objective: </strong>To identify key genes associated with keloid through integrative analysis of multiple transcriptomic datasets, and to explore their potential regulatory roles in disease development with experimental validation.</p><p><strong>Methods: </strong>Transcriptomic data of keloid were retrieved from the Gene Expression Omnibus (GEO) database. Batch effects were corrected using SVA and ComBat. Differentially expressed genes (DEGs) were identified using the <i>limma</i> package. Weighted gene co-expression network analysis (WGCNA) was performed to detect key modules, and intersected with DEGs to obtain candidate genes. Multiple machine learning algorithms were applied to identify key feature genes, which were further validated in independent external datasets. In parallel, wound tissues from a silicone-splinted murine excisional wound model (which recapitulates mechanical tension of human skin injury) and matched normal skin tissues were collected for histological assessment using haematoxylin-eosin (H&E) and Masson staining, and gene expression levels were validated by quantitative real-time PCR (qRT-PCR).</p><p><strong>Results: </strong>A total of 82 DEGs were identified. WGCNA revealed the MEpink module as the key module, and intersection analysis yielded 61 candidate genes, which were primarily enriched in inflammation- and fibrosis-related pathways. Protein-protein interaction network analysis indicated that JAG1 and NR2F2 occupied central positions within the network. Machine learning identified six key feature genes, among which NR2F2 and IL15 showed relatively strong discriminatory performance. Histological analysis demonstrated increased collagen deposition and disorganized tissue architecture in keloid samples. qRT-PCR confirmed that JAG1 and NR2F2 were upregulated in keloid tissues, consistent with transcriptomic findings.</p><p><strong>Conclusion: </strong>JAG1 and NR2F2 participate in inflammation- and fibrosis-related signaling cascades to drive keloid pathogenesis, and possess promising value for the molecular subtyping of keloid lesions. Collectively, our results lay a solid foundation for future mechanistic research on the molecular regulatory networks governing keloid development.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"625100"},"PeriodicalIF":2.5,"publicationDate":"2026-09-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13592341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149016103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinicopathologic Features and Outcomes of Basal Cell Carcinoma Coexisting with Other Tumors or Precancerous Lesions: A Single-Center Analysis.","authors":"Qiannan Jia, Shuaixin Li, Xinran Li, Aiping Fan, Jun Li","doi":"10.2147/CCID.S631812","DOIUrl":"10.2147/CCID.S631812","url":null,"abstract":"<p><strong>Objective: </strong>To characterize the clinicopathologic spectrum, treatment patterns, and outcomes of basal cell carcinoma (BCC) coexisting with other tumors or precancerous lesions.</p><p><strong>Methods: </strong>We retrospectively reviewed pathologically confirmed cases diagnosed at Peking Union Medical College Hospital between 2020 and 2025. Demographic, clinical, histopathologic, treatment, and outcome data were extracted and analyzed.</p><p><strong>Results: </strong>Among 860 pathologically confirmed BCC cases, 17 met the inclusion criteria. The cohort comprised 9 women (52.9%) and 8 men (47.1%), with a mean age of 56.71 ± 21.14 years. Coexisting lesions were classified as hamartoma/nevus-associated (7 cases), keratinocytic lesion-associated (5 cases), or adnexal/cyst-associated (5 cases). Nevus sebaceus was the most frequent coexisting lesion. All lesions involved the head and neck, and 16 (94.1%) showed recent enlargement or another new change on a preexisting lesion. Nodular and superficial BCC predominated. Exploratory comparison with a contemporary head and neck BCC cohort suggested that the present cohort was characterized by younger age, more frequent scalp/frontotemporal involvement, enrichment of superficial BCC, and fewer aggressive subtypes. Most patients had favorable outcomes without recurrence or metastasis observed.</p><p><strong>Conclusion: </strong>BCC coexisting with other tumors or precancerous lesions has a distinct clinicopathologic profile, and often presents as recent changes in a long-standing head/neck lesion. Classification by coexisting lesion type may help integrate clinical morphology, pathology, and risk assessment.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"631812"},"PeriodicalIF":2.5,"publicationDate":"2026-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589976/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012058","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Automated Quantification of Shedding Hairs from Smartphone Photographs Using an AI Tool for Alopecia Monitoring.","authors":"Shiwen Zhang, Yujing Zhang, Xiangqian Li, Pingxin Han, Xinfeng Li, Cheng Zhou","doi":"10.2147/CCID.S641573","DOIUrl":"10.2147/CCID.S641573","url":null,"abstract":"<p><strong>Introduction: </strong>Objective shed-hair counts can support clinical assessment, longitudinal monitoring, and evaluation of treatment response. Manual counting is time-consuming, whereas visual estimates vary between observers. We developed an artificial intelligence (AI) model to count shedding hairs from ordinary smartphone photographs.</p><p><strong>Methods: </strong>Thirty volunteers acquired 5630 home smartphone photographs of dark shedding hairs on light backgrounds, and paired manual counts served as the reference standard. Images were assigned by participant into training/internal validation (24 volunteers, 4509 images) and independent testing (6 volunteers, 1121 images). A weakly supervised density-regression model was trained with image-level counts. A blinded reader study compared AI with visual estimates from 15 readers across 56 paired image sets. A non-randomized sequential refined wash test (RWT) comparison evaluated completion and usable quantitative data in historical manual and subsequent AI-assisted cohorts.</p><p><strong>Results: </strong>In independent testing, AI achieved a mean absolute error (MAE) of 5.4 hairs and a mean absolute percentage error (MAPE) of 7.0%. The mean model-minus-reference bias was -0.8 hairs (95% LoA, -17.0 to 15.4 hairs). In the blinded comparison, AI had lower error than all visual estimation methods (MAE, 6.99 hairs; MAPE, 6.15%; P < 0.001). Median total AI workflow time was 24.5 seconds versus 123.0 seconds for manual counting. Usable RWT data were available for 14 of 48 patients (29.2%) in the historical manual cohort and 23 of 30 (76.7%) in the subsequent AI-assisted cohort (P < 0.001).</p><p><strong>Conclusion: </strong>Under the evaluated dark-hair and light-background conditions, AI provided low-error counts and lower error than human visual estimation. The subsequent AI-assisted RWT cohort more often provided usable quantitative data than the historical manual cohort in this non-randomized sequential comparison. Prospective studies are needed to evaluate workflow feasibility and potential benefits for clinical monitoring and patient outcomes.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"641573"},"PeriodicalIF":2.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589520/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007888","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Post-Traumatic Primary Cutaneous Cryptococcosis Presenting as a Chronic Refractory Forearm Ulcer with Polymicrobial Coinfection: An mNGS-Assisted Case Report and Literature Review.","authors":"Chengxiang Lian, Bin Feng, Jiaguang Su","doi":"10.2147/CCID.S642965","DOIUrl":"10.2147/CCID.S642965","url":null,"abstract":"<p><p>Primary cutaneous cryptococcosis (PCC) is a rare infection caused by direct inoculation of <i>Cryptococcus</i> through disrupted skin. We report a 52-year-old male farmer with type 2 diabetes but no HIV infection or known major immunosuppressive disease who developed chronic refractory ulcers on the right forearm following suspected insect-bite trauma. <i>Cryptococcus neoformans</i> was isolated from cutaneous specimens. Probe-capture metagenomic next-generation sequencing (MetaCAP) of the ulcer tissue additionally detected <i>C. neoformans</i> at 202 reads per million (RPM), accounting for 91.98% of the fungal sequences, with a reported confidence of 99%. Histopathology demonstrated an infectious granuloma, while bacterial culture identified methicillin-resistant <i>Staphylococcus aureus</i> and extended-spectrum β-lactamase-producing <i>Escherichia coli</i>. Chest computed tomography and cerebrospinal fluid investigations did not support pulmonary or central nervous system cryptococcosis. Liposomal amphotericin B was discontinued because of acute kidney injury, and subsequent fluconazole plus flucytosine treatment resulted in reduced exudation, granulation tissue formation, and partial ulcer healing. PCC should be considered in chronic post-traumatic ulcers, with systematic evaluation for extracutaneous involvement before establishing a primary cutaneous diagnosis.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"642965"},"PeriodicalIF":2.5,"publicationDate":"2026-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13589538/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pili Annulati in a Black-Haired Asian Woman.","authors":"Daxing Wu, Jianzhong Xu, Danni Hua, Lifeng Wu","doi":"10.2147/CCID.S631430","DOIUrl":"10.2147/CCID.S631430","url":null,"abstract":"<p><p>Pili annulati (PA) is a rare autosomal dominant hair shaft disorder characterized by alternating light and dark bands along the hair shaft. It is more commonly observed in individuals with blond or light-colored hair, while cases in patients with dark hair are uncommon, as the greater amount of hair pigment can obscure the banding pattern, making it more difficult to recognize. As a valuable adjunctive tool, dermoscopy is valuable for revealing the characteristic features of PA, including alternating bright and dark bands along the hair shaft, sometimes accompanied by multiple white nodes. Here, we report a case of PA in a black-haired Asian woman with a 30-year history. Dermoscopy revealed the typical banding pattern, but notably, no obvious white nodes were observed. The positive family history further supports the familial nature of PA, although it alone is insufficient to establish an autosomal dominant inheritance pattern.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"631430"},"PeriodicalIF":2.5,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588124/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rupioid Porokeratosis on the Lower Leg: An Unprecedented Case Report.","authors":"Xinrong Chen, Guiying Qiu, Yuehuan Bian, Jie Chen","doi":"10.2147/CCID.S629891","DOIUrl":"10.2147/CCID.S629891","url":null,"abstract":"<p><p>Verrucous porokeratosis (VP) is a rare variant that typically presents as solitary hyperkeratotic plaques on acral sites, and atypical morphology or unusual location is exceptionally uncommon. We report a rare case of VP on the right lower leg with a striking rupioid (oyster-shell-like) morphology in a patient with long-standing diabetes mellitus and a history of rectal cancer resection and the patient received oral isotretinoin combined with topical corticosteroids and microcirculation-targeting agents, which was well tolerated and led to clinical improvement, which expanding the clinicopathological spectrum of porokeratosis.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"629891"},"PeriodicalIF":2.5,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588136/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic Potential of Isoniazid in Inflammatory Skin Diseases: A Review.","authors":"Shuokai Zhang, Yi Tang, Jiamin Wen, Jiaqi Song, Wenchen Gong, Ting Chen","doi":"10.2147/CCID.S639038","DOIUrl":"10.2147/CCID.S639038","url":null,"abstract":"<p><strong>Objective: </strong>Isoniazid (INH), a well-established anti-tuberculosis agent, has recently gained increasing interest because of its anti-inflammatory and immunomodulatory properties. This review is intended to summarize the mechanistic basis of INH in inflammatory skin disorders and to assess its potential clinical applicability. However, most evidence discussed here derives from preclinical studies and remains largely hypothesis-generating.</p><p><strong>Materials and methods: </strong>A literature search was performed in the CNKI and PubMed databases.</p><p><strong>Results: </strong>The anti-inflammatory activity of INH is mediated through several pathways, including regulation of the ROS-PPARγ-NF-κB/AP-1 axis, suppression of NLRP3 inflammasome activation, and modulation of the Th1/Th2 balance. Therapeutic potential has been observed in conditions such as atopic dermatitis, psoriasis, urticaria, and rosacea, particularly among patients with latent tuberculosis infection or those undergoing biologic therapy, supporting its dual \"anti-inflammatory-antituberculosis\" value.</p><p><strong>Conclusion: </strong>INH demonstrates a multi-target mode of action and distinct dual clinical advantages in the management of inflammatory skin diseases, rendering it especially relevant for resource-constrained settings and selected patient populations. Additional clinical investigations remain necessary to determine the optimal treatment strategy and to further establish its safety profile. However, clinical evidence remains limited and further prospective studies are needed.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"639038"},"PeriodicalIF":2.5,"publicationDate":"2026-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13588107/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149007891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser-Induced Shock Wave Therapy Using a Diamond Particle Acoustic Patch for Early Facial Scar Modulation: A Case Series.","authors":"Hae Woong Lee, Woo Geon Lee, Sin Woo Sung, Kui Young Park","doi":"10.2147/CCID.S637768","DOIUrl":"10.2147/CCID.S637768","url":null,"abstract":"<p><strong>Background: </strong>Early scar formation represents a dynamic phase of wound healing characterized by active fibroblast proliferation, extracellular matrix remodeling, and mechanosensitive signaling. Interventions applied during this immature stage may modulate scar architecture more effectively than treatments targeting mature scars. Shock wave-based therapies have demonstrated regenerative and remodeling effects in various tissues; however, their application to early cutaneous scar modulation remains limited.</p><p><strong>Objective: </strong>To describe the clinical feasibility and outcomes of laser-induced shock wave therapy (LISWT) using a diamond particle acoustic patch for early scar modulation.</p><p><strong>Methods: </strong>This retrospective four-patient case series included patients with immature (early-phase) facial scars, defined as recently formed scars that remained in the active remodeling phase, characterized clinically by erythema and/or contour alteration before scar maturation, who were treated with LISWT. A diamond particle acoustic patch was applied over the scar area with ultrasound coupling gel, followed by irradiation using a Q-switched 1064-nm Nd:YAG laser. Treatment parameters were adjusted according to scar maturity, and the patients received 3-7 treatment sessions at individualized intervals according to scar characteristics and clinical response. Clinical outcomes were evaluated using standardized photography and validated scar assessment tools, including the Vancouver Scar Scale (VSS), the Patient and Observer Scar Assessment Scale (POSAS), and a patient satisfaction visual analog scale (VAS).</p><p><strong>Results: </strong>All four patients demonstrated progressive improvement in scar contour, texture, and erythema, accompanied by reductions in VSS and POSAS scores. Across the four patients, VSS scores decreased by 4-6 points, POSAS Observer scores by 10-13 points, and POSAS Patient scores by 8-12 points from baseline to final follow-up. Patient-reported satisfaction increased over the treatment course. No clinically significant adverse events or downtime were observed.</p><p><strong>Conclusion: </strong>LISWT using a diamond particle acoustic patch may represent a novel, nonthermal approach for early scar modulation by delivering controlled mechanical stimulation during wound healing. This case series supports its feasibility and short-term safety and warrants further investigation.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"19 ","pages":"637768"},"PeriodicalIF":2.5,"publicationDate":"2026-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC13584945/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148988283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}