Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"The Creation of the Arabic Version of the Hyperhidrosis Quality of Life Index (HidroQoL©) with Validation and Cross-Cultural Adaptation.","authors":"Qais A Almuhaideb, Nasser M AbuDujain, Khalid M Alghamdi","doi":"10.2147/CCID.S498688","DOIUrl":"10.2147/CCID.S498688","url":null,"abstract":"<p><strong>Purpose: </strong>Hyperhidrosis (HH) is characterized by excessive sweating, which can significantly affect quality of life. The Hyperhidrosis Quality of Life Index (HidroQoL©) is the latest tool that has been developed and validated for assessing the quality of life of patients with HH. Because of the absence of an Arabic version of the HidroQoL©, this research aimed to create, validate, and adapt the HidroQoL© into Arabic.</p><p><strong>Patients and methods: </strong>A quantitative, analytical, cross-sectional study was conducted with HH patients followed up in dermatology or thoracic surgery clinics. We assessed the results reliability through internal consistency and reproducibility by assessing test‒retest reliability. For validity, we conducted an exploratory factor analysis with an interitem correlation matrix and a rotated component matrix.</p><p><strong>Results: </strong>A total of 167 participants were enrolled in this study; 61.1% were males, and 92.8% were Saudi. All 18 items of the HidroQoL©, including the daily life activities domain, psychosocial life domain, and whole HidroQoL©, had Cronbach's alpha values above 0.7. The test-retest reliability assessment demonstrated strong reproducibility. The correlations between each item and the other 17 items of the scale were positive, ranging between 0.2 and 0.6, and the results of the components analysis suggested that the questionnaire has three domains. The correlation between the test-retest results of the HidroQoL© revealed a significant strong positive correlation (r=0.9, P˂0.001).</p><p><strong>Conclusion: </strong>Our findings revealed excellent psychometric properties of the Arabic HidroQoL© in terms of structural and construct validity, internal consistency, and reproducibility. Proper utilization of the Arabic HidroQoL© adequately assesses the quality of life of those affected by HH.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"251-263"},"PeriodicalIF":1.9,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064193","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel Immune-Related Three-Gene Signature and Immune Infiltration Insights in Psoriasis and Chronic Kidney Disease.","authors":"Tingting Yin, Tingting Zhang, Lei Ma","doi":"10.2147/CCID.S499202","DOIUrl":"10.2147/CCID.S499202","url":null,"abstract":"<p><strong>Purpose: </strong>There are significant inflammatory correlations and common immune dysregulation features between psoriasis and chronic kidney disease, however, the inflammatory mechanisms of these two diseases have not been clarified. The aim of this study was to screen immunologically related biomarkers for psoriasis and chronic kidney disease with the objective of identifying specific molecular markers to improve the accuracy and sensitivity of disease diagnosis.</p><p><strong>Patients and methods: </strong>To achieve this objective, common differentially expressed genes between psoriasis and chronic kidney disease were first identified. Through further functional analysis, these genes were found to be primarily involved in the activation of inflammation and innate immune responses. Subsequently, six hub genes were determined using five topological algorithms. The responses of these two diseases exhibited similar changes in immune reactions. By cross-analyzing these key genes with known immune genes, three Immunity-Related Hub Genes (IRHGs) were identified, including <i>MX1, DDX58</i>, and <i>ISG20</i>.</p><p><strong>Results: </strong>ROC curve analysis validated the excellent discriminative ability of <i>MX1</i> and <i>ISG20</i> in both diseases. Furthermore, immune infiltration analysis revealed a higher abundance of T cells in samples from both psoriasis and chronic kidney disease, suggesting that T cell-driven immune responses may play a crucial role in the association of these two diseases. Lastly, single-cell analysis observed a significant increase in the cell abundance of T cells and endothelial cells in psoriasis and chronic kidney disease, respectively. The differential expression of <i>MX1, DDX58</i>, and <i>ISG20</i> in these cells suggests that they may be involved to varying degrees in the pathogenic mechanisms of the two diseases.</p><p><strong>Conclusion: </strong>This study provides a theoretical foundation for prognosis assessment and treatment of psoriasis and chronic kidney disease, contributing to a deeper understanding of the immune mechanisms underlying these conditions.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"267-286"},"PeriodicalIF":1.9,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11776511/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064100","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Local Hyperthermia Combined With Imiquimod Cleared Recalcitrant and Extensive Warts in a Patient With Systemic Lupus Erythematosus.","authors":"Gai-Hua Wang, Yang-Bin Wang, Yue-Ai Cheng, Hong-Duo Chen, Xing-Hua Gao, Rui-Qun Qi","doi":"10.2147/CCID.S504378","DOIUrl":"10.2147/CCID.S504378","url":null,"abstract":"<p><p>Viral warts, a common dermatological condition caused by human papillomavirus infection (HPV) infection, present a particular challenge for systemic lupus erythematosus (SLE) patients due to their compromised immunity, which increases the susceptibility to HPV infection and complicates treatment efforts. Imiquimod, an immunomodulatory agent, has demonstrated efficacy in managing warts. Furthermore, local hyperthermia, a non-invasive therapeutic modality, has demonstrated significant potential in the management of warts. We report the case of a SLE patient developed recalcitrant and extensive viral warts on limbs. We applied hyperthermia at 45 °C on a target lesion for 1 hour / day with imiquimod cream 3 times/week. All the lesions cleared in 8 months and there was no sign of recurrence.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"241-244"},"PeriodicalIF":1.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771514/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Facial Lichen Planus Pigmentosus-Like Pigmentation Induced by Vicks VapoRub: A Case Report.","authors":"Khalid M Al-Husain, Musaed M Alsebayel, Sarah Al-Breiki, Nasser Almulhim, Ahmed Alsayyah","doi":"10.2147/CCID.S504299","DOIUrl":"10.2147/CCID.S504299","url":null,"abstract":"<p><p>Lichen planus pigmentosus is a variant of lichen planus characterized by gray-brown hyperpigmented macules and patches occurring in sun exposed areas. Vicks VapoRub is an inhalant ointment frequently used to relieve symptoms of upper respiratory tract infections. We report a case of lichen planus pigmentosus induced by Vicks VapoRub and successfully treated with topical tacrolimus 0.1% cream.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"235-239"},"PeriodicalIF":1.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771172/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051907","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Superficial Mycoses in a Patient with Systemic Lupus Erythematosus.","authors":"Zhen Li, Jiejie Lu, ZhiLi Yang","doi":"10.2147/CCID.S496301","DOIUrl":"10.2147/CCID.S496301","url":null,"abstract":"<p><p>Superficial mycoses are characterized by the infection of keratinized tissues such as the epidermis, hair, and nails. A 52-year-old woman from Hainan Province, China is reported in this study. The patient presents with large erythematous scales on her head, face, and disfigured nails over a 2-year period. The fungal infection was further aggravated by the patient's 10-year history of SLE and long-term immunosuppressive drug therapy. Ultimately, Fungal microscopy and culture results were consistent with superficial mycosis. After 6 months of treatment with terbinafine and itraconazole, the patient's rash subsided, and fungal microscopy was negative. There was no recurrence after six months of follow-up.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"245-250"},"PeriodicalIF":1.9,"publicationDate":"2025-01-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11771178/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051904","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Recalcitrant Female Pattern Hair Loss Like Alopecia Unveils Unexpected Rare Entity.","authors":"Ahmed H Nouh, Fatma M Elgendy, Fatma A Gobran, Maryna S Zhuravlova","doi":"10.2147/CCID.S487399","DOIUrl":"10.2147/CCID.S487399","url":null,"abstract":"<p><strong>Introduction: </strong>Marie-Unna hereditary hypotrichosis (MUHH) is an autosomal dominant disorder characterized by a specific pattern of hair loss. Initially described in 1925 by Marie-Unna in a German family spanning over seven generations, MUHH represents a previously unidentified form of congenital hypotrichosis. It typically presents as sparse hair at birth with a coarse texture, followed by regrowth during childhood then, finally, gradual hair loss at puberty, resembling pattern of androgenetic alopecia.</p><p><strong>Case presentation: </strong>The study describes two cases from different unrelated families presenting with recalcitrant alopecia resembling female pattern hair loss, with dermoscopic findings consistent with pili torti and yellow dots. Genetic testing confirmed a heterozygous pathogenic variant in the HRURF gene, associated with autosomal dominant Marie Unna Hereditary Hypotrichosis. Up to our knowledge it is first case series reported from Egypt.</p><p><strong>Conclusion: </strong>While recent literature on MUHH has primarily focused on identifying genetic abnormalities, there are other important questions that warrant consideration. These include histopathological studies, dermoscopic descriptions, and correlating types of genetic mutations with clinical presentations. These data might offer a deeper understanding of MUHH pathophysiology ending in efficacious treatment options.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"223-233"},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11769844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051911","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of the Effectiveness of Using LED Light Combined With Chromophore Gel in Treating Acne Vulgaris - Preliminary Study.","authors":"Anna Ewa Deda, Magdalena Hartman-Petrycka, Sławomir Wilczyński","doi":"10.2147/CCID.S501140","DOIUrl":"10.2147/CCID.S501140","url":null,"abstract":"<p><strong>Purpose: </strong>The aim was to quantitatively evaluate the effectiveness of LED light therapy combined with photoacceptor substances having anti-acne properties in reducing the symptoms of acne vulgaris.</p><p><strong>Patients and methods: </strong>15 subjects aged 20 to 24 who suffered from moderate or severe acne lesions. The treatments were performed using a LED device (465-880 nm). Blue light - 465 nm in combination with red light - 640 nm in pulsed mode and near-infrared light - 880 nm were used in the treatments. Each patient underwent 6 treatments, with intervals between treatments of 7 days. 3D images and biomechanical measurements were performed before first and fourth treatments and 6 weeks after the last. Additionally, photographic documentation was made 7 days after the 6th treatment.</p><p><strong>Results: </strong>The series of treatments significantly influenced the clinical condition of the patients' skin. The treatments had a statistically significant impact on the intensity of erythema on the left and right cheeks. The hydration of the stratum corneum in all the examined areas of the face changed significantly after the treatments. Greater hydration was achieved six weeks after six treatments compared to the values obtained prior to treatment and after three treatments. The activity of sebaceous glands and, consequently, the amount of sebum on the epidermal surface in all the examined areas of the face changed significantly after the treatments. The treatments had a statistically significant impact on the volume of atrophic scars.</p><p><strong>Conclusion: </strong>Therapy combining LED light with photoacceptor substances is an effective method of reducing the symptoms of acne vulgaris. The treatments lead to a significant reduction in erythema, reduction in the volume of atrophic scars, improvement of skin hydration and regulation of sebum secretion. These effects can be identified quantitatively. Further studies are necessary to confirm the long-term effectiveness and safety of this method.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"207-221"},"PeriodicalIF":1.9,"publicationDate":"2025-01-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11766709/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Novel COL7A1 Mutation in a Patient With Dystrophic Epidermolysis Bullosa. Successful Treatment With Upadacitinib.","authors":"Shuqin Lai, Chunli Lin, Zimeng Guo, Yun Lai, Ling Xie, Chunlei Wan, Tao Yang, Longnian Li","doi":"10.2147/CCID.S499144","DOIUrl":"10.2147/CCID.S499144","url":null,"abstract":"<p><p>Dystrophic epidermolysis bullosa (DEB) is a heterogeneous and rare genetic skin disease caused by mutations in the <i>COL7A1</i> gene, which encodes Type VII collagen. The absence or dysfunction of Type VII collagen can cause the dense lower layer of the basal membrane zone of the skin to separate from the dermis, leading to blister formation and various complications. In different DEB subtypes, the severity of the phenotype is associated, to some extent, with the outcome of Type VII collagen caused by mutations in the <i>COL7A1</i> gene, which may be reduced in expression, remarkably reduced, or completely absent. Here, we report a case of DEB caused by a mutation in the <i>COL7A1</i> gene at a novel site, where the patient achieved favorable outcomes after treatment with upadacitinib. This study further expands the known <i>COL7A1</i> gene mutation sites in the DEB subtype, providing new data for understanding the genotype-phenotype correlation and treatment of this disease.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"183-190"},"PeriodicalIF":1.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11762244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unusual Cutaneous Manifestations in a Patient with a History of Hepatitis B: A Case of Scleromyxedema and Literature Review.","authors":"Aili Gao, Xin Tian, Dexiu Lang, Yue Chen","doi":"10.2147/CCID.S492503","DOIUrl":"10.2147/CCID.S492503","url":null,"abstract":"<p><p>Scleromyxedema (SM) is a rare primary cutaneous mucinosis characterized by systemic papules and scleroderma-like manifestations, often associated with monoclonal gammopathy. We present the case of a 37-year-old male with SM who developed yellowish plaques on the neck and back over three years. Histopathological examination revealed mucin deposition, fibroblast proliferation, and fibrosis, supporting the diagnosis. Serum protein electrophoresis identified IgG-λ type paraproteinemia. Notably, the patient had a history of hepatitis B virus (HBV) infection, suggesting a potential association. Following eight weeks of oral triamcinolone acetonide therapy, the skin lesions improved significantly. Despite established diagnostic criteria for SM, its pathogenesis remains poorly understood. Chronic antigenic stimulation from circulating cytokines and viral infections, such as HBV, may contribute to disease development. This case highlights the potential link between chronic HBV infection and SM, emphasizing the need for further investigation into viral etiologies. SM differs clinically, histologically, and systemically from related disorders such as scleroderma and scleroedema, necessitating careful differentiation for appropriate management. The scarcity of epidemiological data and lack of standardized treatment guidelines for SM in China underscore the challenges clinicians face in diagnosing and managing this rare disease. This case reinforces the importance of multidisciplinary collaboration, particularly when co-infections such as HBV are present. Given the chronic, unpredictable course of SM and its potential systemic involvement, continuous follow-up and vigilant monitoring are essential to optimize patient outcomes.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"201-206"},"PeriodicalIF":1.9,"publicationDate":"2025-01-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11769843/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143051914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Real-World Experience of Clascoterone Cream 1% in Acne Management: Case Series and Canadian Experience.","authors":"Elena Tay, Wei Jing Loo","doi":"10.2147/CCID.S498879","DOIUrl":"10.2147/CCID.S498879","url":null,"abstract":"<p><p>Acne vulgaris is a globally prevalent dermatological condition associated with substantial physical and psychological burden. Although acne typically presents during adolescence, it is a chronic condition that also affects many adults. Despite the spectrum of treatments available for acne, limitations in tolerability and safety concerns can present challenges for the use of conventional medications in clinical practice. Clascoterone cream 1%, a topical androgen receptor inhibitor, was recently approved in Canada for the topical treatment of acne vulgaris. This case series included 10 patients with acne vulgaris who were treated with clascoterone cream 1% as monotherapy or part of a combination treatment program between August 2023 and May 2024. Clascoterone cream 1% was effective and well tolerated regardless of acne severity, age, gender, and ethnicity. Clascoterone led to clinical improvement when used as monotherapy, adjunctive treatment in combination with other topical or systemic agents or laser therapy, and as maintenance therapy to prevent relapse of acne. Moreover, clascoterone also helped to address other concerns in several patients, including hirsutism, hidradenitis suppurativa, retinoid-induced dermatitis, androgenetic alopecia, folliculitis, postinflammatory hyperpigmentation, and laser-induced acne flares. This early real-world clinical experience supports the effectiveness, tolerability, and versatility of clascoterone cream 1% for patients with acne across a variety of clinical and demographic characteristics.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"161-167"},"PeriodicalIF":1.9,"publicationDate":"2025-01-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11760757/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143045802","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}