Clinical, Cosmetic and Investigational Dermatology最新文献_第6页

Exploring the Relationship Between Immune Cells and Non-Scarring Hair Loss: A Mendelian Randomization Study 探索免疫细胞与非瘢痕性脱发之间的关系：孟德尔随机研究

IF 2.3 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-07-06 DOI: 10.2147/ccid.s467185

Hongtao Liu, Xiao Huang, Hongji Wei, Yanchang Nong

{"title":"Exploring the Relationship Between Immune Cells and Non-Scarring Hair Loss: A Mendelian Randomization Study","authors":"Hongtao Liu, Xiao Huang, Hongji Wei, Yanchang Nong","doi":"10.2147/ccid.s467185","DOIUrl":"https://doi.org/10.2147/ccid.s467185","url":null,"abstract":"Background: Non-scarring hair loss (NSHL) is a global health concern with increasing prevalence due to lifestyle changes and an aging population. It can cause psychological distress and affect quality of life. Objective: This study aimed to identify the associations between NSHL and immune cell phenotypes using a two-sample Mendelian randomization (MR) analysis, offering insights for future immune-based therapies for NSHL. Methods: We obtained immunocyte data from the IEU Open GWAS Project and NSHL data from the same database and used MR analysis to evaluate the causal association between each immunophenotype and NSHL. Three statistical methods were employed: the MR-Egger regression, weighted median estimation, and inverse variance weighting (IVW). Results: The MR resonance imaging identified 31 immunocyte phenotypes associated with NSHL. Among these, 19 immunocyte phenotypes were negatively associated with NSHL, indicating their protective effects. The remaining 12 immunocyte phenotypes were positive association. Sensitivity analyses suggested the robustness of all MR findings. Conclusion: These findings highlight a clear correlation between NSHL and immunity, demonstrating the significant role of certain immune cell phenotypes. This study offers a new direction for immune-based therapies in the treatment of NSHL. ","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141549796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recalcitrant Reactive Perforating Collagenosis Successfully Treated with Dupilumab: A Case Report [Corrigendum] 杜匹单抗成功治疗顽固性反应性胶原穿孔病：病例报告 [Corrigendum］

IF 2.3 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-07-05 DOI: 10.2147/ccid.s485214

Jiecheng Li, Cheng Zhou

引用次数: 0

The Roles of Exosomes in Regulating Hair Follicle Growth 外泌体在调节毛囊生长中的作用

IF 2.3 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-07-05 DOI: 10.2147/ccid.s465963

Ming Cheng, Cong Ma, Hong-Duo Chen, Yan Wu, Xue-Gang Xu

引用次数: 0

Treatment of Darier Disease with Radiation Therapy: Case Report and Literature Review 用放射疗法治疗达里尔病：病例报告和文献综述

IF 2.3 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-07-05 DOI: 10.2147/ccid.s473099

Xinzhou Liu, Xiuhuan Wang, Jianke Li, Xiaofeng Shan, Zhongxiang Shi

{"title":"Treatment of Darier Disease with Radiation Therapy: Case Report and Literature Review","authors":"Xinzhou Liu, Xiuhuan Wang, Jianke Li, Xiaofeng Shan, Zhongxiang Shi","doi":"10.2147/ccid.s473099","DOIUrl":"https://doi.org/10.2147/ccid.s473099","url":null,"abstract":"Abstract: Darier’s disease (DD) is an autosomal dominant genodermatosis characterized by hyperkeratotic papules, often accompanied by scaling and crusting. Managing DD presents significant challenges due to the absence of an effective cure, with only symptom targeting treatments currently available. This study presents a case of refractory DD that showed poor response to established pharmacological treatments but demonstrated improvement with low-dose superficial X-ray radiotherapy (SRT). The radiation was delivered as a single 200 cGy treatment, which visibly improved the condition. Considering the different degrees of side effects, sequelae, and risk of developing radiation-induced cancer after exposure to moderate levels of radiation, it may be considered that we attempt to treat recalcitrant DD initially by applying a low dose of radiation in order to mitigate these undesired side effects. If larger doses or additional courses are necessary due to inadequate response, the risks and benefits must be carefully evaluated and discussed with patients. Keywords: Darier disease, superficial X-ray, low-dose of radiation, SRT-100 ","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141549795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Infantile Bullous Pemphigoid: A Case Report 婴儿大疱性类天疱疮：病例报告

IF 2.3 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-07-04 DOI: 10.2147/ccid.s463677

Nouf F Bin Rubaian, Omar Mohammed Alakloby, Deemah S Alhuraish, Nasser Alzoabi, Jamal Alqahtani, Sara Omar AlAkloby, Fatma A AlJindan

{"title":"Infantile Bullous Pemphigoid: A Case Report","authors":"Nouf F Bin Rubaian, Omar Mohammed Alakloby, Deemah S Alhuraish, Nasser Alzoabi, Jamal Alqahtani, Sara Omar AlAkloby, Fatma A AlJindan","doi":"10.2147/ccid.s463677","DOIUrl":"https://doi.org/10.2147/ccid.s463677","url":null,"abstract":"Background: Infantile bullous pemphigoid (IBP) is an exceptionally rare acquired autoimmune subepidermal bullous disorder characterized by vesicles, bullae, and additional manifestations, such as urticarial and infiltrated papules, plaques, or eczematous lesions. These skin lesions can lead to eroded and crusted regions after healing, and in some cases, rapid blister rupturing causes extensively eroded areas. Reporting these rare cases is crucial to improving our understanding, diagnosis, and treatment of IBP. Case Presentation: In this report, we present the clinical case of a 4-month-old male infant with generalized tense bullae causing irritability and sleeplessness. This case highlights the distinctive clinical features of IBP, including the development of multiple generalized tense bullae over 2 weeks. The pathological examination findings confirmed the diagnosis of IBP. Conclusion: This case emphasizes the significance of early identification and proper management of IBP. Our thorough assessment, which incorporates pathological verification and therapeutic interventions, has advanced our understanding of IBP. Additionally, this case underscores the vital need for timely diagnosis and personalized treatment approaches for affected infants. ","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141552894","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Combination of a Topical Anti-Inflammatory Drug and a Moisturizer, Both with a Lamellar Structure Containing Synthetic Pseudo-Ceramides, for the Treatment of Patients with Mild-to-Moderate Atopic Dermatitis 将一种外用消炎药和一种保湿霜（二者均具有含有合成假橘皮酰胺的层状结构）结合使用，治疗轻度至中度特应性皮炎患者

IF 2.3 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-07-03 DOI: 10.2147/ccid.s467934

Keita Okoshi, Shotaro Ito, Megumi Matsuoka, Yoshinori Kinugasa, Eri Shimizu, Kosei Tanaka, Joji Okada, Takahiro Nishizaka, Azumi Nagasawa, Tsuyoshi Seki, Makoto Iijima, Masatoshi Abe, Osamu Nemoto

{"title":"Combination of a Topical Anti-Inflammatory Drug and a Moisturizer, Both with a Lamellar Structure Containing Synthetic Pseudo-Ceramides, for the Treatment of Patients with Mild-to-Moderate Atopic Dermatitis","authors":"Keita Okoshi, Shotaro Ito, Megumi Matsuoka, Yoshinori Kinugasa, Eri Shimizu, Kosei Tanaka, Joji Okada, Takahiro Nishizaka, Azumi Nagasawa, Tsuyoshi Seki, Makoto Iijima, Masatoshi Abe, Osamu Nemoto","doi":"10.2147/ccid.s467934","DOIUrl":"https://doi.org/10.2147/ccid.s467934","url":null,"abstract":"Purpose: Atopic dermatitis is characterized by chronic inflammation and dryness accompanied by severe itching. The combined use of moisturizers and topical anti-inflammatory drugs is essential for alleviating atopic dermatitis. We have developed a topical anti-inflammatory drug with a steroid and a moisturizer with heparinoid, both in lamellar structure-based formulations containing synthetic pseudo-ceramides. Here, assessed the efficacy of this combination in the treatment of atopic dermatitis. Methods: We included 22 patients with mild to moderate atopic dermatitis and subjected them to a seven-week treatment with the test formulations, followed by a four-week post-treatment period. Results: Clinical findings and the quality of life of participants remarkably improved after one week of treatment. Furthermore, skin hydration and transepidermal water loss considerably improved at weeks one and three, respectively. The Cer [NP]/[NS] ratio, an indicator of epidermal turnover, substantially increased during the treatment period and remained elevated even thereafter. The improvement in stratum corneum function was distinctive in participants with lower barrier function. Conclusion: These findings indicated that the combined use of the anti-inflammatory drug and moisturizer, both in lamellar structure-based formulations, is effective in treating atopic dermatitis in patients with fragile barrier function. Keywords: base formulations, lamellar structure, steroid, heparinoid, barrier function, TEWL ","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141532616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Study of Humoral Immune Response to Inactivated COVID-19 Vaccine in Patients with Psoriasis Receiving Biologics and Small Molecules 接受生物制剂和小分子药物治疗的银屑病患者对 COVID-19 灭活疫苗的体液免疫反应研究

IF 2.3 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-07-03 DOI: 10.2147/ccid.s467889

Yang Zou, Yuting Peng, Jing Xu, Aijun Chen, Kun Huang, Ping Wang

引用次数: 0

Independent Risk Factors for Postoperative Recurrence of Patients with Primary Extramammary Paget’s Disease: A Retrospective Analysis 原发性乳腺外 Paget's 病患者术后复发的独立风险因素：回顾性分析

IF 2.3 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-07-01 DOI: 10.2147/ccid.s468103

Zhuangzhi Zhou, Yao Chen, Na Tan, Li Hu

{"title":"Independent Risk Factors for Postoperative Recurrence of Patients with Primary Extramammary Paget’s Disease: A Retrospective Analysis","authors":"Zhuangzhi Zhou, Yao Chen, Na Tan, Li Hu","doi":"10.2147/ccid.s468103","DOIUrl":"https://doi.org/10.2147/ccid.s468103","url":null,"abstract":"Background: Extramammary Paget’s disease (EMPD) is a rare skin cancer with unclear pathogenesis, insidious progression, and high recurrence rate. The purpose of this study was to investigate the clinical features and postoperative recurrence factors of primary EMPD. Methods: We retrospectively analyzed the medical records of 40 patients with primary EMPD who underwent wide local excision surgery at a single medical center between 2009 and 2019. Risk factors for recurrence of primary EMPD were analyzed using multivariate binary logistic regression. Results: The study included 40 patients with primary EMPD, comprising 31 males (77.5%) and 9 females (22.5%), with a median age of 75.52 years (range 52– 99 years). The most common lesion location was the scrotum (22 cases, 55.0%), followed by the vulva, penis, scrotum, underarm and anus. Multivariable regression analysis revealed significant differences in the presence of ill-defined tumour borders, exudation and nodules in the primary lesion affecting the relapse of primary EMPD (p< 0.05). Conclusion: Our findings indicate that ill-defined tumour borders, exudation and nodules in the primary site should be considered as independent risk factors for disease recurrence, which may provide useful suggestions for the diagnosis, treatment and follow-up of primary EMPD. ","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":null,"pages":null},"PeriodicalIF":2.3,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141516960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bimekizumab in Biologics-Refractory Psoriatic Arthritis: A Real-Life Analysis from a Combined Dermatology-Rheumatology Clinic 生物制剂难治性银屑病关节炎中的 Bimekizumab：来自皮肤科与风湿病科联合诊所的现实生活分析

IF 2.3 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-07-01 DOI: 10.2147/ccid.s467832

Alen Zabotti, Nicola Cabas, Ivan Giovannini, Silvia Guella, Lorenzo Cereser, Chiara Zuiani, Giuseppe Stinco, Luca Quartuccio, Enzo Errichetti

引用次数: 0

Erratum: Potential Role of Tranexamic Acid in Rosacea Treatment: Conquering Flushing Beyond Melasma [Corrigendum]. 勘误：氨甲环酸在红斑痤疮治疗中的潜在作用：超越黄褐斑，战胜潮红[更正]。

IF 1.9 4区医学

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2024-06-26 eCollection Date: 2024-01-01 DOI: 10.2147/CCID.S484236

引用次数: 0