Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis.","authors":"Xiaoxia Ding, Zicheng Bai, Wenwen Wang, Yu Gu, Zhiming Li, Yibin Fan","doi":"10.2147/CCID.S492958","DOIUrl":"10.2147/CCID.S492958","url":null,"abstract":"<p><strong>Background: </strong>Prior studies have suggested a significant connection between fasting insulin (FI) and androgenetic alopecia (AGA), but the exact cause of this connection and underlying molecular mechanism has not been clarified. In this study, a Mendelian randomization (MR) analysis was utilized to discover the causal associations between FI and AGA.</p><p><strong>Methods: </strong>Genome-wide association study (GWAS) data for FI and AGA were retrieved, and bidirectional MR analysis was conducted. FI-associated genes were identified through expression quantitative trait loci (eQTL) analysis, with enrichment analysis and a protein-protein interaction (PPI) network used to explore potential pathways and core genes.</p><p><strong>Results: </strong>Forward MR analysis revealed a significant causal relationship between elevated FI levels and AGA (P=0.027, OR=43.944). Reverse MR analysis found no causal effect of AGA on FI (P=0.808, OR=1.0001). A total of 92 FI-associated genes were analyzed, with enrichment results indicating involvement in glycine, serine, and threonine metabolic pathways. EIF2B4 and NRBP1 were identified as potential core genes linking FI and AGA.</p><p><strong>Conclusion: </strong>By using MR analysis, this study verified the possible causative connection between FIns and AGA by MR analysis. The core genes EIF2B4 and NRBP1, along with biological processes such as glycosylation and amino acid metabolism, may serve as crucial links.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"355-365"},"PeriodicalIF":1.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperglycemia Is a Potential Prognostic Factor for Exacerbation in Severe Psoriasis with Diabetes or Prediabetes.","authors":"Tanat Yongpisarn, Kunlawat Thadanipon, Poonkiat Suchonwanit, Ploysyne Rattanakaemakorn","doi":"10.2147/CCID.S502333","DOIUrl":"10.2147/CCID.S502333","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is an immune-mediated skin disease with a chronic relapsing-remitting course. Hyperglycemia has been shown to correlate with psoriasis severity. However, whether it could trigger psoriasis flares is not known.</p><p><strong>Objective: </strong>To investigate the association between hyperglycemia and psoriasis exacerbation.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study at a university-affiliated hospital in Bangkok, Thailand, between 2008 and 2022 to examine the effects of elevated HbA1c on psoriasis flares. Patients with psoriasis vulgaris and either type 2 diabetes mellitus (T2DM) or impaired fasting glucose (IFG) who had at least 2 HbA1c values were identified. Statistical analyses were performed using mixed-effects logistic regression.</p><p><strong>Results: </strong>A total of 201 psoriasis patients (95 with severe psoriasis and 106 with mild psoriasis) with 1,717 follow-up visits were included in the analysis. In patients with severe psoriasis, HbA1c ≥ 7% (adjusted odds ratio (OR): 1.905 (95% confidence interval: 1.328-2.731)) and alcohol consumption status (adjusted OR: 3.328 (1.235-8.965)) were identified as independent prognostic factors for psoriasis flares. Meanwhile, in mild psoriasis patients, none of the variables were independently associated with psoriasis flares.</p><p><strong>Conclusion: </strong>Hyperglycemia and alcohol consumption were associated with exacerbation in patients with severe psoriasis who had T2DM/IFG.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"345-353"},"PeriodicalIF":1.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Associations of Chilblains Prevalence with Connective Tissue Diseases, Including COVID-19 Incidence.","authors":"Yahya Argobi","doi":"10.2147/CCID.S486402","DOIUrl":"10.2147/CCID.S486402","url":null,"abstract":"<p><strong>Background: </strong>Chillblains, also known as perniosis, are inflammatory skin lesions that have long been associated with exposure to low temperatures. However, their co-occurrence with autoimmune illnesses and viral infections, particularly COVID-19, has received increased attention. This study was designed to examine chilblains' documented prevalence and association with autoimmune diseases and COVID-19.</p><p><strong>Methods: </strong>This was a descriptive cross-sectional study carried out at Mass General Brigham (MGB), an extensive integrated healthcare system situated in Greater Boston, Massachusetts. The study included patients with a confirmed diagnosis of chilblains from 2014 to 2021 and COVID-19 from 2020 to 2021. The study was approved by the Mass General Brigham Human Research Committee, ensuring compliance with ethical standards.</p><p><strong>Results: </strong>During the study, 24,711 charts were reviewed, identifying 1478 patients with chilblains, resulting in an overall registered prevalence of 0.02463%. The majority of chilblains patients were female (72.5%), with the highest proportion in the 31-30-year age group (31.3%). 169 (11.43%) patients were identified with autoimmune diseases, predominantly females (94.1%). The most prevalent condition among them was systemic lupus erythematosus (SLE) (52.6%). Among COVID-19-positive patients (n = 88,763), 30 were diagnosed with chilblains, leading to a prevalence of 0.033%. Females (66.7%) and individuals aged 40-50 (56.7%) were predominantly affected.</p><p><strong>Conclusion: </strong>This study found a low prevalence primarily among young females and a significant correlation with connective tissue disorders like SLE. The study also notes a rare occurrence of chilblains in COVID-19 patients, suggesting a possible association that requires further investigation, particularly regarding demographic patterns within this subgroup.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"339-344"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11796437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of Sub-Eyebrow Small Incision Dissection of the Corrugator Supercilii Muscle Combined with Autologous Block Fat Transplantation for the Treatment of Severe Frown Lines.","authors":"Shenxing Tan, Changying Niu, Yiwu Zhang, Zhe Cao, Shan Zhang, Shanshan Ren, Xiaoshen Lu, Yuanyuan Liu","doi":"10.2147/CCID.S492565","DOIUrl":"10.2147/CCID.S492565","url":null,"abstract":"<p><strong>Objective: </strong>To explore the clinical efficacy of small sub-eyebrow incision in severing the corrugator supercilii muscle combined with autologous block fat transplantation for treating severe frown lines.</p><p><strong>Methodology: </strong>Sixteen patients with severe frown lines admitted to our hospital who refused to receive repeated injections of botulinum toxin were selected for treatment through corrugator dissection combined with fat transplantation.</p><p><strong>Results: </strong>No patients had difficulty raising their eyebrows after surgery. They all had a smooth eyebrow shape, no abnormal movement of the eyebrows, and no tissue depression during relaxation or frowning. At 12 months after surgery, the overall patient satisfaction with the treatment was 100%, indicating satisfactory results.</p><p><strong>Conclusion: </strong>Treating severe frown lines with a small incision of corrugator combined with autologous block fat transplantation is more effective than traditional treatment, maintains stable and long-term satisfaction, and is associated with less postoperative complications; therefore, this technique should be promoted for treating severe frown lines.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"331-337"},"PeriodicalIF":1.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11792623/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Combination Fractional Carbon Dioxide Laser Treatment and Bone Marrow Mesenchymal Stem Cell Therapy Enhances the Treatment of Skin Photoaging in a Murine Model System.","authors":"Li Li, Zeyu He, Chengqian Yu, Chao Zhang, Yanqiu Yu, Yuanhong Li, Xuegang Xu","doi":"10.2147/CCID.S490225","DOIUrl":"10.2147/CCID.S490225","url":null,"abstract":"<p><strong>Background: </strong>Fractional carbon dioxide lasers and bone marrow mesenchymal stem cells (BMSCs) are commonly employed in the treatment of skin photoaging.</p><p><strong>Objective: </strong>This study was developed to explore the effects of combination carbon dioxide laser treatment and BMSC injection on skin photoaging and the underlying molecular mechanisms.</p><p><strong>Methods & materials: </strong>In total, 24 mice with experimentally photoaged skin were separated into control, carbon dioxide fractional laser treatment, combination therapy, and BMSC injection groups. Samples of dorsal skin from these animals were subjected to hematoxylin and eosin staining or Masson's trichrome staining. In addition, immunohistochemical analyses and real-time polymerase chain reaction analyses were conducted to detect MMP-3 and MMP-9 expression.</p><p><strong>Results: </strong>After 1 week, both dermal thickness and collagen fiber density were significantly increased in the BMSC and combination treatment groups as compared to the control group (<i>P</i><0.05), while both of these parameters were significantly increased in all treatment groups after 4 weeks relative to the control group (<i>P</i><0.05), with the most pronounced effect in the combination therapy group (<i>P</i><0.05). MMP-3 and MMP-9 mRNA and protein levels in the treatment groups were decreased relative to the control group after 4 weeks.</p><p><strong>Conclusion: </strong>Combination BMSC and carbon dioxide laser therapy was more effective than either of these therapeutic approaches in isolation as a treatment for photoaged skin. The improvement of effect may be due to the decrease of MMP-3 and MMP-9 expression in combination therapy.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"319-330"},"PeriodicalIF":1.9,"publicationDate":"2025-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11803962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effectiveness and Safety of Dupilumab and Tralokinumab for Treating Atopic Dermatitis and Pruritic Skin Disorders in Oncological Patients: A Narrative Review.","authors":"Giuseppe Lauletta, Luca Potestio, Cataldo Patruno, Mario De Lucia, Maddalena Napolitano","doi":"10.2147/CCID.S511559","DOIUrl":"10.2147/CCID.S511559","url":null,"abstract":"<p><strong>Introduction: </strong>Atopic dermatitis (AD) and pruritic skin disorders are increasingly recognized in cancer patients. The management of these conditions in patients with a history or with concomitant cancer presents unique challenges, as traditional systemic therapies may pose risks due to their immunosuppressive effects. In recent years, biologic agents such as dupilumab and tralokinumab have emerged as promising treatments for AD, offering targeted modulation of the immune response with potentially fewer systemic side effects. This article aims to review the current evidence on the safety and efficacy of dupilumab and tralokinumab in treating AD and pruritus among cancer survivors, addressing the potential benefits and considerations for this unique patient population.</p><p><strong>Methods: </strong>A comprehensive analysis of the current medical literature was performed on the PubMed, Ovid, Scopus, Embase, and Cochrane Library databases until December 15, 2024. In conducting this narrative review, Medical Subject Headings (MeSH) terms and medical terminology related to clinical trials and real-life studies were employed, focusing on the pharmacological agents dupilumab, and tralokinumab.</p><p><strong>Discussion: </strong>Patients with active or past cancer are typically excluded from clinical trials of new medications, complicating the evaluation of cancer progression or recurrence risks in these patients setting. The potential use of biologic drugs like dupilumab and tralokinumab in oncological patients marks a significant breakthrough for treating conditions such as eczema and pruritus, which are common in this patient group. Although there are no explicit contraindications for using dupilumab and tralokinumab in patients with active cancer or a history of malignancy, there is no definitive guidance on their use in such cases. Real-world data is emerging, facilitated by collaboration between dermatologists and oncologists, supporting the effectiveness and safety of dupilumab and tralokinumab for managing AD in cancer patients. Nonetheless, larger studies with longer follow-up periods and dedicated pharmacovigilance programs are needed to substantiate these findings.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"311-317"},"PeriodicalIF":1.9,"publicationDate":"2025-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11789671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143122217","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Association Between Skin Microbiota and Malignant Melanoma: Genetic Insights From Mendelian Randomization.","authors":"Xianglong Li, Shuang Wu, Yujie Pan, Ziyan Wu, Zhong Du, Wanying Xie, Qingyu Zhou","doi":"10.2147/CCID.S500172","DOIUrl":"10.2147/CCID.S500172","url":null,"abstract":"<p><strong>Background: </strong>Malignant melanoma (MM) is an extremely aggressive type of skin cancer that represents a major risk to human health. Earlier observational research has indicated that skin microbiota could play a role in the development and advancement of MM. Nevertheless, the causal link between skin microbiota and MM is still unclear.</p><p><strong>Methods: </strong>Utilizing data from genome-wide association studies (GWAS) conducted on a European cohort, we applied Mendelian randomization (MR) to evaluate the causal link between skin microbiota and MM. The analysis involved various MR methodologies, including inverse variance weighting (IVW), MR-Egger regression, weighted median, weighted mode and simple mode. Furthermore, we performed sensitivity analysis employing the intercept test of MR-Egger, the Cochran's Q test, the MR-PRESSO approach, and a leave-one-out method.</p><p><strong>Results: </strong>By conducting MR analysis on the KORA FF4 cohort, we identified several skin microbiotas (ASV003 [Staphylococcus (unc).], ASV016 [Enhydrobacter (unc).], and ASV021 [Micrococcus (unc).]) related with an elevated risk of MM. Conversely, genus: Finegoldia and class: Alphaproteobacteria were shown to inhibit the occurrence of MM. Additionally, MR analysis of the PopGen cohort revealed that ASV021 [Micrococcus (unc).] and family: Moraxellaceae were identified as possible risk factors for MM.</p><p><strong>Conclusion: </strong>Our research offers new insights into the connection between skin microbiota and MM, indicating that skin microbiota might affect the onset and advancement of MM. Therefore, focusing on skin microbiota could be a valuable strategy for the prevention, identification, and management of MM.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"303-310"},"PeriodicalIF":1.9,"publicationDate":"2025-01-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11786603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus Recommendations for the Reconstitution and Aesthetic Use of Poly-D,L-Lactic Acid Microspheres - Comment on the Facial Injection Techniques [Letter].","authors":"Jui-Yu Lin, Chuan-Yuan Lin","doi":"10.2147/CCID.S516035","DOIUrl":"10.2147/CCID.S516035","url":null,"abstract":"","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"287-289"},"PeriodicalIF":1.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784298/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Bioinformatics Analysis of Pyroptosis-Related Genes and Analysis of Immune Cell Infiltration in Infantile Hemangioma Regression.","authors":"Lan Liu, Sheng Lin, Jianxi Bai, Bing Zhang","doi":"10.2147/CCID.S492535","DOIUrl":"10.2147/CCID.S492535","url":null,"abstract":"<p><strong>Background: </strong>Infantile hemangiomas (IHs) are characterized by spontaneous regression, and their pathogenesis involves immune cell infiltration and programmed cell death. The molecular pathways and mechanisms involved in pyroptosis in IHs are still unclear. This study aimed to identify genes related to pyroptosis in IH regression by bioinformatics methods and to explore the effects of these pyroptosis-related genes (PRGs) on disease pathology and immune cell infiltration.</p><p><strong>Methods: </strong>The microarray dataset GSE127487 was assessed to identify differentially expressed genes (DEGs) between proliferation-phase IH (PIHs) and involution-phase IH (IIHs). The DEGs that overlapped with PRGs were considered IH-PRGs. The IH-PRGs were validated and subjected to functional enrichment analysis and Genomes pathway analyses. Gene set enrichment analysis (GSEA) was also performed to analyse the biological significance of the DEGs. The NetworkAnalyst database was used to analyse the correlation network of IH-PRGs and miRNAs as well as that of IH-PRGs and transcription factors. The STRING online database and Cytoscape were used to identify the hub-IH-PRGs. Additionally, a single-sample GSEA algorithm was applied to assess immune cell infiltration in IHs, and correlation analysis was performed between the hub-IH-PRGs and infiltrating immune cells.</p><p><strong>Results: </strong>Fourteen IH-PRGs were identified. IL6, EGFR, IRF1 and IL32 were identified as hub-IH-PRGs and displayed excellent diagnostic performance. Immune cell infiltration analysis revealed notable differences in CD8+ T cells, Tgd cells and Th17 cells between PIHs and IIHs. IL-6 was significantly positively correlated with Th17 cell infiltration and significantly negatively correlated with Tgd cell infiltration; EGFR was negatively correlated with Tgd cell infiltration; and IRF1 and IL32 were significantly negatively correlated with Th17 cell infiltration.</p><p><strong>Conclusion: </strong>Four PRGs, namely, IL6, EGFR, IRF1 and IL32, may play a significant role in IH regression. This study provides insights into the molecular mechanisms underlying IH pathogenesis, highlighting the importance of pyroptosis and immune cell infiltration.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"291-302"},"PeriodicalIF":1.9,"publicationDate":"2025-01-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11784316/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143078767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus Recommendations for the Reconstitution and Aesthetic Use of Poly-D,L-Lactic Acid Microspheres - Comment on the Reason of \"Fast Reconstitution\" [Letter].","authors":"Jui-Yu Lin, Chuan-Yuan Lin","doi":"10.2147/CCID.S516553","DOIUrl":"10.2147/CCID.S516553","url":null,"abstract":"","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"265-266"},"PeriodicalIF":1.9,"publicationDate":"2025-01-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11774764/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064120","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}