Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"Dermatosis Neglecta and Chilblain Lupus Erythematosus Occurred Post Surgery of Basal Cell Carcinoma: A Case Report.","authors":"Guomin Gao, Jiayun Liu, Rui Sun, Xuankai Liu, Dan Meng, Weiyuan Ma","doi":"10.2147/CCID.S509485","DOIUrl":"10.2147/CCID.S509485","url":null,"abstract":"<p><p>Dermatosis neglecta (DN) is a rare condition, often linked to psychosomatic disorders, with an unclear etiology. Chilblain lupus erythematosus (CHLE) constitutes a rare variant of cutaneous lupus erythematosus, frequently mistaken for idiopathic chilblain due to its chilblain-like lesions. To date, no instances of concurrent DN and CHLE occurring at the site of a skin flap or graft have been documented. Herein, we present a case that the occurrence of DN and CHLE developed on a skin flap at once. The simultaneous occurrence of DN and CHLE on a skin flap is exceptionally rare. Clinicians must exercise heightened vigilance due to the common misdiagnosis of CHLE. Various skin disorders can manifest on skin flaps and grafts post-transplantation. Thus, clinicians must remain vigilant for both recurrence and metastasis during post-operative monitoring, while also attending to patients' mental well-being and the condition of skin flaps.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"419-426"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481829","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Types and Characteristics of Hair Across the Globe: Results of a Multinational Study on 19,461 Individuals.","authors":"Frederic Flament, Aurelie Maudet, Philippe Barbarat, Meriem Jabnoun, Muriel Bayer-Vanmoen, Audrey Imbert Legrain, Stephanie Leclerc-Mercier, Charles Taieb, Charbel Skayem, Laurence Lebarbanchon","doi":"10.2147/CCID.S377009","DOIUrl":"10.2147/CCID.S377009","url":null,"abstract":"<p><strong>Introduction: </strong>Hair plays a critical role in enhancing physical appearance, self-esteem, and identity. However, the impact of hair characteristics on daily life has received limited attention. This study aimed to assess the types and characteristics of hair, their variations according to age, gender, ethnicity, and country, and their effects on individuals' daily lives.</p><p><strong>Methods: </strong>A study was conducted between February 2022 and June 2023 across nine countries: USA, France, Brazil, India, China, Mexico, Japan, South Africa, and Indonesia. A total of 19,461 participants aged 18 and older were selected using stratified, proportional sampling. Participants completed a structured digital questionnaire evaluating hair thickness, type, damage, and curl degree, alongside questions on stress, sleep, and well-being. Data were analyzed using descriptive statistics and statistical tests (<i>T</i>-test, Pearson's test).</p><p><strong>Results: </strong>Thin hair was reported by 23.7% of males and 29.2% of females. Dry hair was more common in females (38.9%) than males (32.1%). Damaged hair was reported by 47% of females and 30% of males. Ethnic differences showed that thick hair was most common in African (40.7%) and least in Asian (26.3%) populations. The impact of hair type on daily life varied significantly across countries. Individuals with damaged or dry hair experienced higher stress, lack of sleep, and poor well-being, especially in Japan, India, and France. Hair type (straight, wavy, curly, kinky) also affected personal and professional stress levels differently in each country.</p><p><strong>Conclusion: </strong>Our research shows that hair characteristics significantly influence daily life, self-image, and well-being, with notable variations by gender, ethnicity, and country. These findings highlight the need for interventions to address the psychological and social impacts of hair issues, contributing to better healthcare, body image, and product development.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"393-404"},"PeriodicalIF":1.9,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11846515/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143481830","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Causal Relationship Between Blood Metabolomics and Female Pattern Hair Loss: A Bidirectional Mendelian Randomization Study.","authors":"Lin Peng, Xu Zhao, Liangliang Shen, Lili Zhang, Yu Han, Lutong Li, Miao Jiang","doi":"10.2147/CCID.S494185","DOIUrl":"10.2147/CCID.S494185","url":null,"abstract":"<p><strong>Background: </strong>Metabolic disorders have been hypothesized to be associated with female-pattern hair loss. However, ambiguity persists regarding the causality and directionality of the relationship between blood metabolites and female hair loss patterns.</p><p><strong>Methods: </strong>To evaluate the causal relationship between 1400 blood metabolites and female pattern hair loss, we conducted a bidirectional Mendelian randomization analysis using publicly available summary data from genome-wide association studies. The primary analyses employed the inverse variance weighted method supplemented by the weighted median, MR-Egger, and weighted mode approaches. To control for multiple testing, the false discovery rate method was applied to adjust P values. The leave-one-out method was employed for the sensitivity analysis. Heterogeneity was evaluated using Cochran's Q value, whereas horizontal pleiotropy was assessed using MR-Egger intercept and MR-PRESSO. Additionally, metabolic pathway analysis was performed for the metabolites that demonstrated significant correlations. We further performed colocalization analysis to delve into the underlying causality.</p><p><strong>Results: </strong>After rigorous selection, 23 metabolites and 4 metabolic ratios were associated with female-pattern hair loss. There were no noticeable outliers, horizontal pleiotropy, or heterogeneity. Metabolic pathway analysis identified one significant pathway: fructose/mannose metabolism (P < 0.05). In the reverse analysis, dimethylglycine was identified as overlapping with the forward analysis results, thereby removing it from the final analysis.</p><p><strong>Conclusion: </strong>Through integration of genomic and metabolomic data, we identified blood metabolites that may be associated with the development of female pattern hair loss. Our findings provide novel insights into the pathogenic mechanisms of this condition. These findings have significant implications for early diagnosis, preventive measures, and treatment.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"383-392"},"PeriodicalIF":1.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844202/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cladribine Ameliorates Imiquimod Induced Murine Psoriasiform Dermatitis.","authors":"Jingwen Xue, Dan Shu, Yi Zhao","doi":"10.2147/CCID.S511351","DOIUrl":"10.2147/CCID.S511351","url":null,"abstract":"<p><strong>Background: </strong>Significant progress has been made in understanding the mechanisms of psoriasis, particularly the role of the interleukin (IL)-23/T-helper (Th) 17 axis, leading to novel, targeted therapies. However, many patients develop resistance to treatment over time. Thus, exploring new therapeutic strategies for severe refractory psoriasis remains crucial.</p><p><strong>Objective: </strong>To investigate the effect of cladribine on imiquimod induced psoriasiform dermatitis in mice.</p><p><strong>Methods: </strong>We established an imiquimod (IMQ)-induced psoriasiform dermatitis mouse model to investigate cladribine's effects on skin immune cells. Mice were allocated to five groups: Control, IMQ, High-dose cladribine (30mg/kg), Low-dose cladribine (20mg/kg), and Methotrexate. We assessed cumulative scores, skin pathology, immunohistochemistry, flow cytometry, and serum cytokines. We also studied cladribine's long-term efficacy by reapplying IMQ for a second round (7 days) after five half-lives of cladribine.</p><p><strong>Results: </strong>Cladribine significantly ameliorated symptoms and pathological features of IMQ-induced psoriasis in both high and low-dose groups, with efficacy comparable to methotrexate. Cladribine dose-dependently reduced Th17 and Th1 cell frequencies in psoriatic skin, along with associated cytokines. High-dose cladribine demonstrated sustained inhibition of IMQ-induced psoriasis.</p><p><strong>Conclusion: </strong>These findings indicate that cladribine can ameliorate imiquimod-induced psoriasiform dermatitis in mice, exhibiting a dose-dependent and sustained therapeutic effect.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"405-415"},"PeriodicalIF":1.9,"publicationDate":"2025-02-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11844302/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143482385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus Recommendations for the Reconstitution and Aesthetic Use of Poly-D,L-Lactic Acid Microspheres - Comment on the Facial Injection Techniques [Response to Letter].","authors":"Fabiano Nadson Magacho-Vieira","doi":"10.2147/CCID.S519851","DOIUrl":"10.2147/CCID.S519851","url":null,"abstract":"","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"381-382"},"PeriodicalIF":1.9,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834671/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448438","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Consensus Recommendations for the Reconstitution and Aesthetic Use of Poly-D,L-Lactic Acid Microspheres - Comment on the Reason of \"Fast Reconstitution\" [Response to Letter].","authors":"Fabiano Nadson Magacho-Vieira","doi":"10.2147/CCID.S519991","DOIUrl":"10.2147/CCID.S519991","url":null,"abstract":"","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"379-380"},"PeriodicalIF":1.9,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11834646/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448440","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Restless Legs Syndrome in Psoriasis: A Multicenter Study on Its Prevalence, Severity, and Impact on Patients.","authors":"Chuyen Thi Hong Nguyen, Nguyet Huu Minh Nguyen, Trung The Van","doi":"10.2147/CCID.S502902","DOIUrl":"10.2147/CCID.S502902","url":null,"abstract":"<p><strong>Purpose: </strong>Psoriasis is a chronic inflammatory skin disease often associated with multiple comorbidities, including restless leg syndrome (RLS). However, the prevalence and impact of RLS on quality of life and clinical outcomes in patients with psoriasis remain underexplored, particularly in Asian populations. In this study, we compared the prevalence of RLS in patients with psoriasis and healthy controls and evaluated the association between RLS and quality of life, sleep disturbances, and clinical severity of psoriasis.</p><p><strong>Patients and methods: </strong>This multicenter, cross-sectional study involved 212 participants (106 patients with psoriasis and 106 healthy controls) and was conducted from March to July 2024 at three major hospitals in Ho Chi Minh City, Vietnam. RLS was diagnosed according to the International Restless Leg Syndrome Study Group (IRLSSG) criteria. The RLS severity, sleep quality, quality of life, and psoriasis severity were assessed using the Restless Legs Syndrome Rating Scale, Pittsburgh Sleep Quality Index, Dermatology Life Quality Index, and Psoriasis Area and Severity Index (PASI), respectively.</p><p><strong>Results: </strong>The prevalence of RLS was significantly higher in patients with psoriasis than in healthy controls. Patients with psoriasis and RLS exhibited significantly poorer sleep quality and a greater impact on quality of life than those without RLS. The RLS group exhibited a higher PASI score, indicating more severe psoriasis. A strong positive correlation was observed between PASI and RLS severity.</p><p><strong>Conclusion: </strong>RLS is significantly more prevalent in patients with psoriasis and is associated with worse sleep quality, greater impairment of quality of life, and increased psoriasis severity. Early screening for RLS in patients with psoriasis using the IRLSSG criteria may facilitate timely intervention and improve outcomes.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"367-378"},"PeriodicalIF":1.9,"publicationDate":"2025-02-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11832437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the Causal Relationship and Molecular Mechanisms Between Fasting Insulin and Androgenetic Alopecia: A Mendelian Randomization Study with Bioinformatics Analysis.","authors":"Xiaoxia Ding, Zicheng Bai, Wenwen Wang, Yu Gu, Zhiming Li, Yibin Fan","doi":"10.2147/CCID.S492958","DOIUrl":"10.2147/CCID.S492958","url":null,"abstract":"<p><strong>Background: </strong>Prior studies have suggested a significant connection between fasting insulin (FI) and androgenetic alopecia (AGA), but the exact cause of this connection and underlying molecular mechanism has not been clarified. In this study, a Mendelian randomization (MR) analysis was utilized to discover the causal associations between FI and AGA.</p><p><strong>Methods: </strong>Genome-wide association study (GWAS) data for FI and AGA were retrieved, and bidirectional MR analysis was conducted. FI-associated genes were identified through expression quantitative trait loci (eQTL) analysis, with enrichment analysis and a protein-protein interaction (PPI) network used to explore potential pathways and core genes.</p><p><strong>Results: </strong>Forward MR analysis revealed a significant causal relationship between elevated FI levels and AGA (P=0.027, OR=43.944). Reverse MR analysis found no causal effect of AGA on FI (P=0.808, OR=1.0001). A total of 92 FI-associated genes were analyzed, with enrichment results indicating involvement in glycine, serine, and threonine metabolic pathways. EIF2B4 and NRBP1 were identified as potential core genes linking FI and AGA.</p><p><strong>Conclusion: </strong>By using MR analysis, this study verified the possible causative connection between FIns and AGA by MR analysis. The core genes EIF2B4 and NRBP1, along with biological processes such as glycosylation and amino acid metabolism, may serve as crucial links.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"355-365"},"PeriodicalIF":1.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812677/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hyperglycemia Is a Potential Prognostic Factor for Exacerbation in Severe Psoriasis with Diabetes or Prediabetes.","authors":"Tanat Yongpisarn, Kunlawat Thadanipon, Poonkiat Suchonwanit, Ploysyne Rattanakaemakorn","doi":"10.2147/CCID.S502333","DOIUrl":"10.2147/CCID.S502333","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is an immune-mediated skin disease with a chronic relapsing-remitting course. Hyperglycemia has been shown to correlate with psoriasis severity. However, whether it could trigger psoriasis flares is not known.</p><p><strong>Objective: </strong>To investigate the association between hyperglycemia and psoriasis exacerbation.</p><p><strong>Methods: </strong>We conducted a retrospective cohort study at a university-affiliated hospital in Bangkok, Thailand, between 2008 and 2022 to examine the effects of elevated HbA1c on psoriasis flares. Patients with psoriasis vulgaris and either type 2 diabetes mellitus (T2DM) or impaired fasting glucose (IFG) who had at least 2 HbA1c values were identified. Statistical analyses were performed using mixed-effects logistic regression.</p><p><strong>Results: </strong>A total of 201 psoriasis patients (95 with severe psoriasis and 106 with mild psoriasis) with 1,717 follow-up visits were included in the analysis. In patients with severe psoriasis, HbA1c ≥ 7% (adjusted odds ratio (OR): 1.905 (95% confidence interval: 1.328-2.731)) and alcohol consumption status (adjusted OR: 3.328 (1.235-8.965)) were identified as independent prognostic factors for psoriasis flares. Meanwhile, in mild psoriasis patients, none of the variables were independently associated with psoriasis flares.</p><p><strong>Conclusion: </strong>Hyperglycemia and alcohol consumption were associated with exacerbation in patients with severe psoriasis who had T2DM/IFG.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"345-353"},"PeriodicalIF":1.9,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11809405/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143390312","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Associations of Chilblains Prevalence with Connective Tissue Diseases, Including COVID-19 Incidence.","authors":"Yahya Argobi","doi":"10.2147/CCID.S486402","DOIUrl":"10.2147/CCID.S486402","url":null,"abstract":"<p><strong>Background: </strong>Chillblains, also known as perniosis, are inflammatory skin lesions that have long been associated with exposure to low temperatures. However, their co-occurrence with autoimmune illnesses and viral infections, particularly COVID-19, has received increased attention. This study was designed to examine chilblains' documented prevalence and association with autoimmune diseases and COVID-19.</p><p><strong>Methods: </strong>This was a descriptive cross-sectional study carried out at Mass General Brigham (MGB), an extensive integrated healthcare system situated in Greater Boston, Massachusetts. The study included patients with a confirmed diagnosis of chilblains from 2014 to 2021 and COVID-19 from 2020 to 2021. The study was approved by the Mass General Brigham Human Research Committee, ensuring compliance with ethical standards.</p><p><strong>Results: </strong>During the study, 24,711 charts were reviewed, identifying 1478 patients with chilblains, resulting in an overall registered prevalence of 0.02463%. The majority of chilblains patients were female (72.5%), with the highest proportion in the 31-30-year age group (31.3%). 169 (11.43%) patients were identified with autoimmune diseases, predominantly females (94.1%). The most prevalent condition among them was systemic lupus erythematosus (SLE) (52.6%). Among COVID-19-positive patients (n = 88,763), 30 were diagnosed with chilblains, leading to a prevalence of 0.033%. Females (66.7%) and individuals aged 40-50 (56.7%) were predominantly affected.</p><p><strong>Conclusion: </strong>This study found a low prevalence primarily among young females and a significant correlation with connective tissue disorders like SLE. The study also notes a rare occurrence of chilblains in COVID-19 patients, suggesting a possible association that requires further investigation, particularly regarding demographic patterns within this subgroup.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"339-344"},"PeriodicalIF":1.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11796437/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143255014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}