Clinical, Cosmetic and Investigational Dermatology最新文献

{"title":"A Telemedicine-Based Approach for Acne Management: Method Overview and Demographic Profile of Early Participants.","authors":"Ines Mordente, Francesco Puglia, Riccardo Cassese","doi":"10.2147/CCID.S526952","DOIUrl":"10.2147/CCID.S526952","url":null,"abstract":"","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2259-2265"},"PeriodicalIF":2.2,"publicationDate":"2025-09-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433630/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145069389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Resveratrol in Dermatological Therapy: A Critical Review of Mechanisms, Delivery Innovations, and Clinical Frontiers.","authors":"Quanrui Cui, Heping Wang","doi":"10.2147/CCID.S543849","DOIUrl":"10.2147/CCID.S543849","url":null,"abstract":"<p><p>The management of complex dermatological disorders, including chronic inflammatory diseases, non-healing wounds, and skin malignancies, often faces significant challenges. These include limited efficacy against chronic or relapsing conditions, the emergence of drug-resistant pathogens, and significant side effects from long-term therapies. This clinical gap highlights the urgent need for novel therapeutic agents. Resveratrol (RES), a natural polyphenol with pleiotropic bioactivities, has emerged as a compelling candidate substantiated by its diverse modulatory effects on cutaneous pathophysiology. This review aims to critically synthesize the evidence for RES's efficacy, dissect its foundational mechanisms, and explore innovations in drug delivery designed to overcome its clinical limitations. This review critically synthesizes evidence of the efficacy of RES in managing challenging dermatological conditions, including chronic wounds, psoriasis, atopic dermatitis, melanoma, acne, and herpes simplex virus infections, by dissecting its foundational antioxidant, anti-inflammatory, and immunomodulatory mechanisms. Its therapeutic action is mediated through critical molecular pathways, notably the activation of SIRT1/AMPK and suppression of NF-κB, which collectively mitigate oxidative stress, normalize cellular proliferation, and recalibrate immune responses. Although systemic bioavailability limitations have historically hindered RES's clinical translation, innovative delivery systems, including nanoparticles, hydrogels, and advanced transdermal formulations, are now revolutionizing its topical application and markedly enhancing its localized efficacy and stability. This review consolidates robust preclinical evidence from animal models demonstrating RES-driven accelerated wound healing, diminished inflammatory markers, and significant tumor suppression while also appraising nascent yet promising clinical trial data that indicate good tolerability and initial efficacy in human subjects. Ultimately, this synthesis crystallizes RES as a versatile and promising therapeutic agent in dermatology, concurrently underscoring the imperative for continued innovation in delivery methodologies and execution of large-scale stringently designed clinical trials to fully unlock its therapeutic potential.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2229-2242"},"PeriodicalIF":2.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433249/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"MAIT Cells with High PFN1 Expression Mediate Immune Activation and Metabolic Reprogramming in Psoriasis.","authors":"Man-Ning Wu, Yue-Min Zou, Xiang-Nan Zhou, Sangwon Hong, Lei Wang, Yan-Ping Bai","doi":"10.2147/CCID.S535795","DOIUrl":"10.2147/CCID.S535795","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is a chronic inflammatory skin disease involving dysregulated immune responses and complex genetic factors. This study combines single-cell RNA sequencing (scRNA-seq), gene expression profiling, and genetic analysis to explore cellular and molecular contributors to psoriasis.</p><p><strong>Methods: </strong>Single-cell RNA-seq data (n = 3 psoriasis, n = 2 control; GSE228421) were used for cell-type annotation and functional characterization. T cell subsets were analyzed for differentiation trajectories and cell-cell communication. Differentially expressed genes in mucosal-associated invariant T (MAIT) cells were evaluated by enrichment analysis. Candidate gene causality was tested via eQTL-based Mendelian randomization (MR) and supported by bulk RNA-seq validation.</p><p><strong>Results: </strong>MAIT cells were enriched in psoriatic lesions and exhibited strong intercellular interactions. Functional analyses revealed activation of IL6-JAK-STAT3 signaling, TNF-NFκB pathway, and glycolysis in MAIT cells. MR identified RPS20 as a protective factor (OR = 0.5994, p = 0.011) and PFN1 as a potential risk gene (OR = 1.7229, p = 0.037), with PFN1 highly expressed in MAIT cells. Colocalization analysis showed no significant genetic overlap between PFN1 expression and psoriasis risk. Metabolic profiling revealed differential pathway involvement in PFN1+ and PFN1- MAIT cells.</p><p><strong>Conclusion: </strong>Our integrative analysis highlights MAIT cells and PFN1 as likely contributors to psoriasis pathogenesis. These findings offer insights into immune and metabolic alterations, suggesting potential targets for therapeutic intervention.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2243-2257"},"PeriodicalIF":2.2,"publicationDate":"2025-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433214/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Updates in the Treatment of Rosacea with γ-Aminobutyric Acid Derivatives.","authors":"Dansheng Li, Wanqing Yang, Nuoran Chen, Yang Xu","doi":"10.2147/CCID.S550614","DOIUrl":"10.2147/CCID.S550614","url":null,"abstract":"<p><p>Neurogenic inflammation plays an important role in the pathogenesis of rosacea. Recently, several clinical studies have found that γ-aminobutyric acid (GABA) derivatives can effectively improve the erythema and burning symptoms of rosacea. The underlying mechanisms may relate to the ability of GABA derivatives to inhibit the transient receptor potential channel pathway, subsequently reducing abnormal neuronal activation, inhibiting neuropeptide release, and suppressing neurogenic inflammation. This paper aimed to comprehensively review the progress of fundamental and clinical research on the role of neurogenic inflammation in the pathogenesis of rosacea and the application of GABA derivatives in rosacea treatment. We believe this paper will provide new directions for the treatment of rosacea. PubMed, China National Knowledge Infrastructure, and Web of Science databases were searched for relevant literature. The literature review revealed that GABA derivatives, such as pregabalin and gabapentin, may be effective in relieving the redness and erythema symptoms of rosacea. The potential mechanisms and the effects of GABA derivatives in rosacea treatment were reviewed, providing a new basis for the treatment of rosacea.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2207-2214"},"PeriodicalIF":2.2,"publicationDate":"2025-09-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12423259/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145063646","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Case Report: Pirfenidone-Induced Toxic Epidermal Necrolysisa a Rare Idiosyncratic Reaction.","authors":"Mingang Zhu, Yin Wang, Sheng Wei, Guang Chen, Er-Min Gu","doi":"10.2147/CCID.S550569","DOIUrl":"10.2147/CCID.S550569","url":null,"abstract":"<p><p>Toxic epidermal necrolysis (TEN) is a rare and low incidence rate disease characterized by pirfenidone-induced skin damage. Pirfenidone is a new anti-fibrotic and anti-inflammatory drug that can alleviate the deterioration of lung function in patients with COVID-19-induced pneumonia and prolong the progression-free survival period. However, side effects of pirfenidone have drawn widespread attention, which include gastrointestinal symptoms, liver damage, skin photosensitivity, and rash. So far, many cases caused by pirfenidone have been reported. As far as we know, cases of TEN induced by pirfenidone have rarely been reported. This article presents cases of TEN induced by pirfenidone, so that clinicians can be aware of the possibility of TEN when using pirfenidone, and how to use inflammation-relevant indicators for evaluating the severity and risk of death of TEN, which has potential clinical value.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2201-2205"},"PeriodicalIF":2.2,"publicationDate":"2025-09-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12420916/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Integrative Analysis Reveals a Key Role for CDKN1A in Impaired Wound Healing in Diabetic Patients.","authors":"Sis Aghayants, Shengzhi Zhou, Keyu Zhu, Zhixiang Tan, Bomin Cheng, Song Gong, Zhanyong Zhu","doi":"10.2147/CCID.S534876","DOIUrl":"10.2147/CCID.S534876","url":null,"abstract":"<p><strong>Background: </strong>Diabetic foot ulcers (DFUs) are a common and severe complication of diabetes, often resulting in chronic non-healing wounds. This study aims to investigate the role of cyclin-dependent kinase inhibitor 1A (CDKN1A) in diabetic wound healing, focusing on its impact on cell proliferation and differentiation in DFUs.</p><p><strong>Methods: </strong>We utilized single-cell RNA sequencing (scRNA-seq) to analyze gene expression profiles from DFUs tissues, comparing healing and non-healing groups. Differential gene expression analysis was performed to identify key regulators of wound healing. Mendelian randomization (MR) was employed to explore the causal relationship between CDKN1A expression and metabolic dysfunction in DFUs. Transcription factor analysis was also conducted to identify potential upstream regulators of CDKN1A.</p><p><strong>Results: </strong>Our study confirmed that CDKN1A played a pivotal role in inhibiting cell proliferation and promoting premature differentiation in DFUs, which contributed to impaired wound healing. FOS was identified as a key transcription factor that upregulates CDKN1A in non-healing DFUs. MR analysis identified CDKN1A as being associated with metabolic changes, including the α-ketobutyrate/pyruvate ratio, leading to the impaired healing process in non-healing DFUs.</p><p><strong>Conclusion: </strong>These findings shed light on the molecular mechanisms underlying DFU healing, suggesting that targeting FOS and CDKN1A could offer novel therapeutic strategies for enhancing wound healing in diabetic patients.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2149-2166"},"PeriodicalIF":2.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417700/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Beyond the Algorithm: A Perspective on Tackling Bias and Cultural Sensitivity in AI-Guided Aesthetic Standards for Cosmetic Surgery in the Middle East and North Africa (MENA) Region.","authors":"Abdulrahman Makhseed, Husain Arian, Ali Shuaib","doi":"10.2147/CCID.S543045","DOIUrl":"10.2147/CCID.S543045","url":null,"abstract":"<p><p>Artificial intelligence (AI) is increasingly reshaping cosmetic surgery by enhancing surgical planning, predicting outcomes, and enabling objective aesthetic assessment. Through narrative synthesis of existing literature and case studies, this perspective paper explores the issue of algorithmic bias in AI-powered aesthetic technologies and presents a framework for culturally sensitive application within cosmetic surgery practices in the Middle East and North Africa (MENA) region. Existing AI systems are predominantly trained on datasets that underrepresent MENA phenotypes, resulting in aesthetic recommendations that disproportionately reflect Western beauty ideals. The MENA region, however, encompasses a broad spectrum of beauty standards that merge traditional cultural aesthetics with modern global trends, posing unique challenges for AI integration. To ensure ethical and clinically relevant deployment, AI systems must undergo fundamental changes in algorithm design, including the incorporation of culturally diverse datasets with adequate MENA representation, implementation of cultural competency principles, and active collaboration with regional healthcare professionals. The framework outlines concrete criteria for evaluating cultural representativeness in AI training data and outcome assessments, supporting future empirical validation. Developing culturally aware AI tools is both a moral obligation and a clinical priority. This framework provides both a moral imperative and clinical pathway for ensuring AI serves to support, rather than homogenize, the region's diverse aesthetic traditions.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2173-2182"},"PeriodicalIF":2.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12416507/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145029017","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Eosinophilia Induced by Biosimilar Adalimumab (CinnoRA) in a Patient with Psoriasis and Psoriatic Arthritis: A Case Report.","authors":"Roya Saedpanah, Atiye Rashidi, Alireza Firooz","doi":"10.2147/CCID.S546208","DOIUrl":"10.2147/CCID.S546208","url":null,"abstract":"<p><strong>Background: </strong>Psoriasis is a chronic inflammatory skin disorder that can significantly impact quality of life. Biologic therapies, such as TNF-alpha inhibitors, have improved clinical outcomes but may rarely cause hematologic abnormalities, including eosinophilia. Eosinophilia is uncommon but can be associated with allergic reactions or organ involvement.</p><p><strong>Case presentation: </strong>We report a 33-year-old male with psoriasis and psoriatic arthritis who developed asymptomatic marked eosinophilia after eight doses of biosimilar adalimumab (CinnoRA). Baseline peripheral blood eosinophil percentage was 3.2%, which increased to 19.9% during therapy. Alternative causes, including parasitic infection, allergy, and hematologic disease, were excluded. CinnoRA was discontinued, and eosinophil counts normalized during follow-up.</p><p><strong>Conclusion: </strong>This case illustrates that unexplained eosinophilia can occur during TNF-alpha inhibitor therapy. While routine monitoring is not universally recommended based on a single case, clinicians should consider eosinophilia as a possible adverse reaction, especially in symptomatic patients or those with persistently elevated counts.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2183-2188"},"PeriodicalIF":2.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12418804/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039269","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Case of Generalised Varicella in an Adult.","authors":"Li Lin, Ruzhi Zhang","doi":"10.2147/CCID.S535689","DOIUrl":"10.2147/CCID.S535689","url":null,"abstract":"<p><p>Severe varicella is relatively rare in adults and may lead to death. Our case report describes a 36-year-old man with generalized papules and vesicles. The diagnosis was severe varicella, tinea cruris and type 2 diabetes. Generalized rash of severe varicella is very rare in clinically. In this patient, three days after the appearance of the rash, the CD4+T/CD8+T ratio increased, as did the serum levels of IFN-γ, TNF-α, and IL-17A, suggesting that the balance of the immune system was disturbed and there was an increased likelihood of viral infection, which may be related to the generalized spread of the lesions. The patient was discharged from the hospital after 2 weeks of antiviral treatment along with hepatoprotective, hypoglycemic and antifungal treatment of the buttocks with the lesions significantly reduced.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2167-2172"},"PeriodicalIF":2.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417587/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039273","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Effects of Physical Activity on Skin Health: A Narrative Review.","authors":"Feng Li, Shuang Li, Haibo Xie","doi":"10.2147/CCID.S554263","DOIUrl":"10.2147/CCID.S554263","url":null,"abstract":"<p><p>Physical activity (PA) is crucial for a healthy lifestyle and significantly impacts skin health by boosting blood circulation, skin cell metabolism, stress regulation and anti-inflammatory compound production. However, intense exercise or exercise without protective measures can negatively affect the skin, causing irritation, redness, and even skin cancer. This review compiles studies on the effects of physical activity on skin health. PA benefits skin health by enhancing blood flow, which boosts oxygen and nutrient delivery, leading to a healthier complexion. It also increases endorphin production, reducing stress and inflammation. Regular PA improves sleep, aiding skin cell repair through increased human growth hormone. To optimize the role of PA in promoting skin health, it is essential to monitor individual skin type and sensitivity during PA. Additionally, prudent use of sunscreen, sun-protective clothing, and appropriate post-exercise skin hygiene is crucial. In summary, PA represents a double-edged sword in relation to skin health; while moderate exercise can enhance skin health, intense exercise or inadequate protective measures may exacerbate skin disorders.</p>","PeriodicalId":10447,"journal":{"name":"Clinical, Cosmetic and Investigational Dermatology","volume":"18 ","pages":"2189-2200"},"PeriodicalIF":2.2,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12417714/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145039304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}