Assessing Causality Between Androgenetic Alopecia with Depression: A Bidirectional Mendelian Randomization Study.

IF 1.9 4区医学 Q3 DERMATOLOGY

Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-02-22 eCollection Date: 2025-01-01 DOI:10.2147/CCID.S501182

Haiyang Li, Haibin Cai, Pingwei Li, Yibin Zeng, Yao Zhang

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引用次数: 0

Abstract

Background: Androgenetic alopecia (AGA) is the most common form of alopecia globally, which exerts a negative impact on patients' self-esteem and overall quality of life. Previous observational studies have found a significant increase in the prevalence of depression in AGA patients, but the causal relationship remains to be elucidated.

Methods: In this study, we conducted a bidirectional Mendelian randomization (MR) using genome-wide association studies (GWAS) datasets. The available GWAS dataset of AGA was obtained from the Neale Lab consortium (n=154988). The dataset for depression was obtained from the ebi-a-GCST90038650 (n=484598). The main analysis method for determining the causal link between AGA and depression was inverse variance weighted (IVW). Subsequently, pleiotropy and heterogeneity tests were performed to determine the reliability of the results.

Results: Utilizing the IVW method, depression does not significantly contribute to the incidence of AGA (IVW odds ratio [OR] = 1.101, 95% confidence interval [CI] =0.890-1.362, P = 0.374). Conversely, the data suggested a statistically significant association where AGA may precipitate the development of depression, with a notable increase in risk (IVW OR = 1.015, 95% CI = 1.002-1.029, P = 0.020).

Conclusion: We are the first to use MR analysis to explore the causal relationship between AGA and depression, revealing an increased risk of depression in individuals with AGA.

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评估雄激素性脱发与抑郁症之间的因果关系：一项双向孟德尔随机研究。

背景：雄激素性脱发（AGA）是全球最常见的脱发形式，对患者的自尊和整体生活质量产生负面影响。先前的观察性研究发现，AGA患者抑郁患病率显著增加，但其因果关系仍有待阐明。方法：在本研究中，我们使用全基因组关联研究（GWAS）数据集进行了双向孟德尔随机化（MR）。AGA的可用GWAS数据集来自Neale Lab consortium （n=154988）。抑郁症的数据集来自ebi-a-GCST90038650 （n=484598）。确定AGA与抑郁症之间因果关系的主要分析方法是逆方差加权（IVW）。随后，进行多效性和异质性检验以确定结果的可靠性。结果：采用IVW方法，抑郁对AGA的发生率无显著影响（IVW优势比[OR] = 1.101, 95%可信区间[CI] =0.890-1.362, P = 0.374）。相反，数据显示AGA可能加速抑郁症的发展具有统计学意义的关联，其风险显著增加（IVW OR = 1.015, 95% CI = 1.002-1.029, P = 0.020）。结论：我们首次使用磁共振分析来探讨AGA与抑郁症之间的因果关系，揭示了AGA患者患抑郁症的风险增加。

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来源期刊

Clinical, Cosmetic and Investigational Dermatology Medicine-Dermatology

CiteScore

2.80

自引率

4.30%

发文量

353

审稿时长

16 weeks

期刊介绍： Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.