Prevention and Management of Complications With a Hyaluronic Acid-Calcium Hydroxyapatite Hybrid Injectable.

IF 1.9 4区 医学 Q3 DERMATOLOGY
Clinical, Cosmetic and Investigational Dermatology Pub Date : 2025-02-21 eCollection Date: 2025-01-01 DOI:10.2147/CCID.S506038
Wolfgang G Philipp-Dormston, Koenraad De Boulle, David B Eccleston, Rachna Murthy, Karim Sayed, Philippe Snozzi, Fernando Urdiales-Galvez
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引用次数: 0

Abstract

Background: A ready-to-use hyaluronic acid-calcium hydroxyapatite (HA-CaHA) hybrid injectable has a dual mode of action for soft-tissue augmentation. Although previous studies have reported a favorable safety profile for HA-CaHA, there is a need for guidelines and recommendations based on real-world clinical experience for the management of complications associated with HA-CaHA.

Purpose: This publication provides guidelines and recommendations for the prevention and management of HA-CaHA-related complications. A case study example, treatment algorithms, and injection techniques are included to illustrate the management of complications.

Materials and methods: On January 25, 2023, 13 European physicians were invited to an advisory board meeting to discuss strategies for optimizing patient care, minimizing adverse events (AEs), and identifying data gaps for the prevention and management of complications with HA-CaHA.

Results: The management of a subset of AEs, including skin discoloration and edema, was discussed. Small group workshops also shared management algorithms for late noninflammatory adverse reactions, late inflammatory adverse reactions, localized vascular complications, and retinal vascular complications. Best practices for optimal injection techniques were discussed, and injection-technique protocols were developed for treatment sites. Treatment strategies for HA-CaHA-related complications are considered similar to treatment of those resulting from single-agent fillers, and knowledge of anatomy, aseptic technique, correct injection techniques, and appropriate posttreatment care is emphasized.

Conclusion: These recommendations on the management of HA-CaHA-related complications may serve as a reference for the broad range of clinicians using HA-CaHA hybrid injectable for different indications and can help optimize patient outcomes and safety.

透明质酸-羟基磷灰石钙混合注射剂并发症的预防和处理。
背景:一种现成的透明质酸-羟基磷灰石钙(HA-CaHA)混合注射剂具有双重作用模式,用于软组织增强。尽管先前的研究报告了HA-CaHA的良好安全性,但仍需要基于实际临床经验的指南和建议来管理HA-CaHA相关的并发症。目的:本出版物为ha - caha相关并发症的预防和管理提供指南和建议。一个案例研究的例子,治疗算法和注射技术,包括说明并发症的管理。材料和方法:2023年1月25日,13名欧洲医生被邀请参加咨询委员会会议,讨论优化患者护理、最小化不良事件(ae)以及确定HA-CaHA并发症预防和管理的数据缺口的策略。结果:讨论了一系列ae的处理,包括皮肤变色和水肿。小组研讨会还分享了晚期非炎症性不良反应、晚期炎症性不良反应、局部血管并发症和视网膜血管并发症的管理算法。讨论了最佳注射技术的最佳实践,并制定了治疗部位的注射技术方案。ha - caha相关并发症的治疗策略被认为与单药填充物引起的并发症的治疗相似,并强调解剖学知识、无菌技术、正确的注射技术和适当的治疗后护理。结论:这些关于HA-CaHA相关并发症处理的建议可为临床医生广泛使用HA-CaHA混合注射剂治疗不同适应症提供参考,并有助于优化患者的预后和安全性。
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来源期刊
CiteScore
2.80
自引率
4.30%
发文量
353
审稿时长
16 weeks
期刊介绍: Clinical, Cosmetic and Investigational Dermatology is an international, peer-reviewed, open access journal that focuses on the latest clinical and experimental research in all aspects of skin disease and cosmetic interventions. Normal and pathological processes in skin development and aging, their modification and treatment, as well as basic research into histology of dermal and dermal structures that provide clinical insights and potential treatment options are key topics for the journal. Patient satisfaction, preference, quality of life, compliance, persistence and their role in developing new management options to optimize outcomes for target conditions constitute major areas of interest. The journal is characterized by the rapid reporting of clinical studies, reviews and original research in skin research and skin care. All areas of dermatology will be covered; contributions will be welcomed from all clinicians and basic science researchers globally.
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