Climacteric最新文献_第4页

Analysis of multimorbidity patterns in perimenopausal women based on medical examination data. 基于医学检查资料的围绝经期妇女多病模式分析。

IF 3.2 4区医学

Climacteric Pub Date : 2025-08-01 Epub Date: 2025-03-07 DOI: 10.1080/13697137.2025.2470449

Wenjun Luo, Jinning Mao, Shu Su, Meng Jia, Shili Xian, Jiaxian An, Xiaoya Qi, Lihong Mu

{"title":"Analysis of multimorbidity patterns in perimenopausal women based on medical examination data.","authors":"Wenjun Luo, Jinning Mao, Shu Su, Meng Jia, Shili Xian, Jiaxian An, Xiaoya Qi, Lihong Mu","doi":"10.1080/13697137.2025.2470449","DOIUrl":"10.1080/13697137.2025.2470449","url":null,"abstract":"Objective: The concurrent presence of multiple chronic diseases, termed multimorbidity, is increasingly prevalent among patients with chronic illnesses. This phenomenon is particularly pronounced in middle-aged women, yet has not received adequate attention. The objective of this study was to investigate the pattern of multimorbidity and its changes over time in perimenopausal women.Methods: A longitudinal study was conducted on the coexistence of chronic diseases in 3990 middle-aged women aged 40-65 years. The primary analytical tools were association rule mining and cross-lagged panel modeling, applied to the comprehensive medical examination data of the cohort.Result: At the first medical examination, 77.72% of participants were diagnosed with two or more chronic diseases, a figure that rose to 86.98% by the last examination. The most frequently observed multimorbidity combination pair under strong association rules is obesity and dyslipidemia. Additionally, the findings indicated that central obesity significantly influences lipid composition.Conclusion: This study highlights the elevated prevalence of multimorbidity in perimenopausal women and the added complexity of endocrine-related disorders at this life stage. There is an urgent need to develop personalized health management strategies for this demographic and to monitor and intervene in their health status in order to achieve healthy aging for perimenopausal women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"456-463"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the menopause journey. 了解更年期之旅。

IF 3.2 4区医学

Climacteric Pub Date : 2025-08-01 Epub Date: 2025-02-04 DOI: 10.1080/13697137.2024.2445303

Nanette Santoro

{"title":"Understanding the menopause journey.","authors":"Nanette Santoro","doi":"10.1080/13697137.2024.2445303","DOIUrl":"10.1080/13697137.2024.2445303","url":null,"abstract":"The menopause experience is unique to people with ovaries who attain an age at which functioning follicles are depleted. Unlike male reproductive aging, menopause is accompanied by a definable reproductive milestone in that menstrual periods cease and the failure of follicle growth results in a large drop in circulating estrogen and no further ovarian production of progesterone. While the focus on menopause has largely been centered on this absence of hormone production, the most dynamic changes in symptoms and health markers begin before the final menstrual period, and merit attention. Vasomotor symptoms, the most common symptom of menopause and the primary symptom that drives women to seek treatment, peak in frequency and prevalence in the late menopause transition, when women are still having menstrual periods. Body composition and adverse lipoprotein and lipid changes also worsen most acutely in the late transition, and then assume a slower, age-related trajectory of change. Multiple processes that worsen across the transition restabilize after it is over. The notion that the menopause transition is an adaptive process for women has scientific merit and suggests that facilitating this adaptation and recognizing its implications may represent the next phase of progress in the field.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"384-388"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12319117/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhancing quality of life: addressing vulvovaginal atrophy and urinary tract symptoms. 提高生活质量：解决外阴阴道萎缩和尿路症状。

IF 3.2 4区医学

Climacteric Pub Date : 2025-08-01 Epub Date: 2025-06-18 DOI: 10.1080/13697137.2025.2514029

Angelica Lindén Hirschberg

{"title":"Enhancing quality of life: addressing vulvovaginal atrophy and urinary tract symptoms.","authors":"Angelica Lindén Hirschberg","doi":"10.1080/13697137.2025.2514029","DOIUrl":"10.1080/13697137.2025.2514029","url":null,"abstract":"About 50% of postmenopausal women experience symptoms of vulvovaginal atrophy (VVA) including vulvovaginal dryness, burning, itching and dyspareunia as a natural physiological consequence of hypoestrogenism. These symptoms can have a major impact on quality of life and sexual function. VVA is a component of genitourinary syndrome of menopause, also associated with urinary tract problems such as frequent urination, urge incontinence and recurrent urinary tract infections. Vaginal low-dose estrogen is an effective treatment for symptoms of VVA, overactive bladder and urge incontinence, and prevents recurrent urinary tract infections. In contrast, systemic menopausal hormone therapy seems to worsen urinary incontinence. Women with breast cancer treated with aromatase inhibitors often have severe symptoms of VVA and urinary tract problems. Non-hormonal lubricants and moisturizers should be the first-line treatment in these patients. However, there is no evidence of increased cancer recurrence by low-dose vaginal estrogen in breast cancer survivors. When non-hormonal products are ineffective, low-dose vaginal estrogen could be considered in collaboration with the woman's oncologist. An individualized approach is required for the management of VVA and urinary tract symptoms. As VVA is a chronic condition, women should not be denied long-term use of vaginal estrogens if the treatment is of benefit to them.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"400-407"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144324607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatments in women experiencing natural menopause: a cohort study from the USA, the UK and Germany. 自然绝经妇女的治疗：一项来自美国、英国和德国的队列研究。

IF 3.2 4区医学

Climacteric Pub Date : 2025-07-30 DOI: 10.1080/13697137.2025.2530466

Mariam Saadedine, Victoria Banks, Carina Dinkel-Keuthage, Cecilia Caetano, George Argyriou, Carsten Moeller, Nils Schoof, David Vizcaya, Maja Francuski, Asieh Golozar, Thomas Römer, Ali Kubba

{"title":"Treatments in women experiencing natural menopause: a cohort study from the USA, the UK and Germany.","authors":"Mariam Saadedine, Victoria Banks, Carina Dinkel-Keuthage, Cecilia Caetano, George Argyriou, Carsten Moeller, Nils Schoof, David Vizcaya, Maja Francuski, Asieh Golozar, Thomas Römer, Ali Kubba","doi":"10.1080/13697137.2025.2530466","DOIUrl":"https://doi.org/10.1080/13697137.2025.2530466","url":null,"abstract":"Objectives: This study aimed to describe treatment patterns among naturally menopausal women from the USA, the UK and Germany.Methods: Using health claims (the USA) and electronic health records (the UK and Germany), women aged 40-65 years with a first record of natural menopause (index date) from 2009 to 2022 were identified. Women with a history of bilateral oophorectomy, total hysterectomy, endocrine therapy for breast cancer or hormone/non-hormone therapy for menopausal symptoms were excluded. Treatments evaluated following the index date were hormone therapy, benzodiazepines, antidepressants, anticonvulsants and the antihypertensive clonidine.Results: In total, 1,260,742 (the USA), 214,374 (the UK) and 124,542 (Germany) women were included, and treatments were recorded in 38.8%, 33.4% and 28.8%, respectively. Among these, the majority received one treatment class, mostly hormone therapy (44.2% for the USA, 41.1% for the UK, 92.6% for Germany), benzodiazepines (25.3% for the USA, 6.8% for the UK, 2.2% for Germany) and antidepressants (18.6% for the USA, 33.5% for the UK, 4.1% for Germany). Discontinuation rates at 6 months from starting initial treatment were 75.0-88.0% for hormone therapy, 65.0-85.0% for antidepressants and ≥98% for benzodiazepines. Treatment switches occurred in 25.4% (the USA), 21.8% (the UK) and 1.7% (Germany).Conclusions: Continuation rates with current treatments for women experiencing natural menopausal symptoms are low, indicating an unmet need for effective and acceptable therapies.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-8"},"PeriodicalIF":3.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Factors associated with the age of natural menopause in the ELSA-Brasil cohort. elsa -巴西队列中与自然绝经年龄相关的因素

IF 3.2 4区医学

Climacteric Pub Date : 2025-07-30 DOI: 10.1080/13697137.2025.2530458

Luana Karla Leite, Lidyane V Camelo, Rafaela Dias Rodrigues, Maria da Conceição Chagas de Almeida, Mariana Santos Felisbino-Mendes, Gustavo Velasquez-Melendez, Rosane Harter Griep, Sandhi Maria Barreto, Alexandra Dias Moreira

{"title":"Factors associated with the age of natural menopause in the ELSA-Brasil cohort.","authors":"Luana Karla Leite, Lidyane V Camelo, Rafaela Dias Rodrigues, Maria da Conceição Chagas de Almeida, Mariana Santos Felisbino-Mendes, Gustavo Velasquez-Melendez, Rosane Harter Griep, Sandhi Maria Barreto, Alexandra Dias Moreira","doi":"10.1080/13697137.2025.2530458","DOIUrl":"https://doi.org/10.1080/13697137.2025.2530458","url":null,"abstract":"Objective: This study aimed to investigate socio-demographic, reproductive, lifestyle and health factors associated with the age of natural menopause in the Brazilian context.Method: The cross-sectional study was conducted with data from 3538 women who reported natural menopause from the baseline (2008-2010) to the date of the second visit (2012-2014) of the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil). The outcome of the study was the age of natural menopause. The association between socio-demographic, reproductive, lifestyle and health characteristics and the age of menopause were investigated using multiple linear regression.Results: The mean age of natural menopause was 49.5 years. The following conditions were associated with a younger age at onset of menopause: lower education level, historically marginalized races/skin colors and smoking. By contrast, multiparity and contraceptive use for less than 3 years were associated with a higher mean age at the onset of menopause, related to no previous pregnancies and no contraceptive use.Conclusion: The study findings provide relevant support for the development of public policies aimed at preventing early menopause and promoting comprehensive and continuous care for women's health.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-9"},"PeriodicalIF":3.2,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144741372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resistance training and bone mineral density in rodent models of menopause: review and meta-analysis. 绝经期啮齿动物模型的阻力训练和骨密度：综述和荟萃分析。

IF 3.2 4区医学

Climacteric Pub Date : 2025-07-29 DOI: 10.1080/13697137.2025.2530434

Pedro Gustavo Machado, Juliana Cristina Dos Reis Canaan, Luciana Botelho Ribeiro, Adriana Pinto Bezerra, Thaís Marques Simek-Vega Gonçalves, Eric Francelino Andrade, Pedro Curi Hallal, Luciano José Pereira

{"title":"Resistance training and bone mineral density in rodent models of menopause: review and meta-analysis.","authors":"Pedro Gustavo Machado, Juliana Cristina Dos Reis Canaan, Luciana Botelho Ribeiro, Adriana Pinto Bezerra, Thaís Marques Simek-Vega Gonçalves, Eric Francelino Andrade, Pedro Curi Hallal, Luciano José Pereira","doi":"10.1080/13697137.2025.2530434","DOIUrl":"https://doi.org/10.1080/13697137.2025.2530434","url":null,"abstract":"The decline in bone mineral density (BMD) is common among older adults, especially due to reduced sex hormone production in women (menopause). Understanding the impact of resistance training on bone tissue is essential for developing effective strategies for the prevention and treatment of this condition. This study investigated the effects of resistance training on BMD in rodent models of osteopenia induced by ovariectomy. The protocol was registered on PROSPERO (CRD42024549460). Inclusion criteria focused on ovariectomized (OVX) female rats and mice engaged in resistance training, with no restrictions on duration, frequency or intensity. A comprehensive search across six databases (and grey literature) identified 314 articles, of which 18 were selected. Resistance training, compared to control groups, significantly increased BMD, particularly in the femur and tibia. The included studies employed various training protocols, such as climbing, jumping and squatting, with variations in training duration and intensity. The meta-analysis demonstrated standardized mean differences of 3.02 (95% confidence interval 1.81-4.24) for climbing and 1.27 (95% confidence interval 0.72-1.82) for jumping protocols, quantifying the extent of improvement in BMD - particularly in the femur and tibia - observed in OVX rodents subjected to resistance training, as compared to sedentary controls. These findings suggest that resistance training positively impacts bone remodeling and may help restore bone microarchitecture in postmenopausal conditions.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-10"},"PeriodicalIF":3.2,"publicationDate":"2025-07-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Complementary therapies for women with premature ovarian insufficiency: a systematic literature review to inform the 2024 update of the ESHRE/ASRM/IMS/CRE-WHiRL guidelines on premature ovarian insufficiency. 卵巢早衰女性的补充治疗：一项系统的文献综述，为2024年更新的ESHRE/ASRM/IMS/CRE-WHiRL卵巢早衰指南提供信息。

IF 3.2 4区医学

Climacteric Pub Date : 2025-07-28 DOI: 10.1080/13697137.2025.2530441

Alison Maunder, Nathalie Vermeulen, Amanda J Vincent, Nick Panay, Carolyn Ee

{"title":"Complementary therapies for women with premature ovarian insufficiency: a systematic literature review to inform the 2024 update of the ESHRE/ASRM/IMS/CRE-WHiRL guidelines on premature ovarian insufficiency.","authors":"Alison Maunder, Nathalie Vermeulen, Amanda J Vincent, Nick Panay, Carolyn Ee","doi":"10.1080/13697137.2025.2530441","DOIUrl":"https://doi.org/10.1080/13697137.2025.2530441","url":null,"abstract":"Objective: Premature ovarian insufficiency (POI) is associated with reduced quality of life and increased health risks. While hormone therapy (HT) is standard treatment, some women seek other options to treat its sequelae. This review explores the role of complementary therapies for POI.Method: A systematic search of four databases up to January 2024 identified randomized controlled trials, systematic reviews, meta-analyses and umbrella reviews that examined the use of complementary therapies by women with POI. Outcomes included menopausal symptoms, gonadotropins, antral follicle count, ovarian volume and quality of life. Study quality was evaluated using Cochrane Risk of Bias and A MeaSurement Tool to Assess systematic Reviews (AMSTAR 2).Results: The search identified 1869 citations, with nine studies meeting the inclusion criteria. Findings suggest that Chinese herbal medicine and acupuncture may alleviate menopausal symptoms and regulate gonadotropins in women with POI, although evidence is very limited. There is insufficient evidence for other complementary therapies for POI.Conclusion: While Chinese herbal medicine may improve menopausal symptoms, there is insufficient evidence specific to POI. There is a clear need for additional and rigorous research on the efficacy and safety of complementary therapies for POI. Evidence does not support complementary medicines as replacements for HT.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-9"},"PeriodicalIF":3.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women's experience and management of cognition during menopause transition: a qualitative study. 绝经过渡期妇女认知体验与管理：一项定性研究。

IF 3.2 4区医学

Climacteric Pub Date : 2025-07-28 DOI: 10.1080/13697137.2025.2530449

Lexi He, Nicole G Jaff, Nora Bahhar, Danielle Proctor, Aimee Spector

{"title":"Women's experience and management of cognition during menopause transition: a qualitative study.","authors":"Lexi He, Nicole G Jaff, Nora Bahhar, Danielle Proctor, Aimee Spector","doi":"10.1080/13697137.2025.2530449","DOIUrl":"10.1080/13697137.2025.2530449","url":null,"abstract":"Objective: Women experience menopause around the age of 45-55 years. Cognitive dysfunction is one of the most prevalent menopausal complaints. This focus group study aimed to explore cognitive experiences and management during the menopause transition.Methods: Eighteen participants, including 15 women in menopause transition from multi-ethnic backgrounds and three healthcare professionals, were recruited to five focus groups conducted between June and August 2024.Results: Thematic analysis yielded three overarching themes: cognitive changes relevant to the menopause transition; multidimensional impacts of cognitive changes; and holistic management of cognitive changes. From participants' narratives, 12 cognitive domains were affected in the menopause transition. These in turn had psychological, social and behavioral impact, resulting in the need to use various coping strategies.Conclusion: The findings of this study identified cognitive challenges in the menopause transition. Women's current coping with cognitive dysfunction addressed the multidimensionality of menopausal management and highlighted unmet needs regarding cognitive health. The research identified cognitive challenges beyond memory and concentration in the menopause transition. Associations of menopause-related factors, culture and ethnicity with cognitive function warrant further investigation for potential intervention development.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-7"},"PeriodicalIF":3.2,"publicationDate":"2025-07-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144728351","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment, perceptions and burden of vasomotor symptoms among midlife women in Japan. 日本中年妇女血管舒缩症状的治疗、认知和负担

IF 2.9 4区医学

Climacteric Pub Date : 2025-07-25 DOI: 10.1080/13697137.2025.2530484

Masakazu Terauchi, Marina Kato, Takumi Lee, Takashi Miki, Sari Mishina

{"title":"Treatment, perceptions and burden of vasomotor symptoms among midlife women in Japan.","authors":"Masakazu Terauchi, Marina Kato, Takumi Lee, Takashi Miki, Sari Mishina","doi":"10.1080/13697137.2025.2530484","DOIUrl":"https://doi.org/10.1080/13697137.2025.2530484","url":null,"abstract":"Objective: This study aimed to investigate the association between the severity of vasomotor symptoms (VMS) and the burden of the condition in the real-world setting within Japan.Methods: The cross-sectional survey study was administered as a web-based questionnaire involving perimenopausal and postmenopausal women. Respondents were female at birth, 40-64 years old and had ≥1 episode of VMS in the prior 12 months. The primary objective was to understand the treatment landscape related to mild to severe VMS. Secondary objectives were to understand attitudes to VMS, opinions on available treatments and impact of VMS on quality of life (QoL).Results: The target population included 2188 respondents. Only 219 (10.0%) respondents visited a medical facility for VMS, and 123 (5.6%) women consulted a doctor when visiting for other treatment. Being able to cope with symptoms was the most common reason for not attending a medical institution. More than half who received treatment were prescribed traditional Chinese medicine (181/325 [55.7%] respondents) and one-third received hormone therapy (108 [33.2%] respondents). Severe VMS were associated with lower QoL, worse sleep quality and reduced work productivity.Conclusions: Women in Japan with VMS do not typically visit medical institutions or receive appropriate medical intervention even when they are aware of VMS and feel some burden.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-12"},"PeriodicalIF":2.9,"publicationDate":"2025-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144706555","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treatment patterns of menopausal hormone therapy in South Korea: a nationwide cohort study. 韩国绝经期激素治疗的治疗模式：一项全国性队列研究。

IF 2.9 4区医学

Climacteric Pub Date : 2025-07-24 DOI: 10.1080/13697137.2025.2524165

Sungwook Chun, Kyungyeon Jung, Bin Hong, Ju-Young Shin, Ji Young Lee

{"title":"Treatment patterns of menopausal hormone therapy in South Korea: a nationwide cohort study.","authors":"Sungwook Chun, Kyungyeon Jung, Bin Hong, Ju-Young Shin, Ji Young Lee","doi":"10.1080/13697137.2025.2524165","DOIUrl":"https://doi.org/10.1080/13697137.2025.2524165","url":null,"abstract":"Objective: Menopausal hormone therapy (MHT) is the most effective treatment for menopausal symptoms. While guidelines recommend an individualized risk-benefit assessment of MHT, real-world studies on use of MHT are limited.Method: Nationwide claims data in South Korea (2015-2020) were used to assess the prevalence of hospital visits for menopausal symptoms and use of MHT among women aged 40-59 years. MHT was classified into three classes including estrogen therapy (ET), estrogen plus progestogen therapy (EPT) and tibolone, with routes of administration categorized as systemic (oral, transdermal) and local (transvaginal). A longitudinal study was conducted to evaluate treatment patterns of MHT.Results: Approximately 9% of women visited hospitals for menopausal symptoms, with fewer than half prescribed MHT. Of 1,774,674 women with menopausal symptoms, 1,036,294 were prescribed MHT: 89,237 patients were started on systemic ET, 300,999 on systemic EPT, 306,538 on tibolone and 378,764 on local ET. Use of tibolone and local ET increased over time, while systemic ET and EPT decreased. Systemic MHT was discontinued after an average of 13.2 months, while local MHT was discontinued after 2.4 months.Conclusion: Despite guidelines recommending MHT for treating menopausal symptoms, many women remain untreated and continued MHT for an average of only 1 year.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144697758","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0