Climacteric最新文献_第10页

Effect and mechanism of recombinant human fibroblast growth factor 18 on osteoporosis in OVX mice. 重组人成纤维细胞生长因子 18 对 OVX 小鼠骨质疏松症的影响和机制

IF 2.9 4区医学

Climacteric Pub Date : 2024-06-01 Epub Date: 2024-01-26 DOI: 10.1080/13697137.2024.2302967

P Y Lu, M Huang, M H Shao, J X Hu, C Y Ding, Y J Feng, M Zhang, H P Lin, H S Tian

{"title":"Effect and mechanism of recombinant human fibroblast growth factor 18 on osteoporosis in OVX mice.","authors":"P Y Lu, M Huang, M H Shao, J X Hu, C Y Ding, Y J Feng, M Zhang, H P Lin, H S Tian","doi":"10.1080/13697137.2024.2302967","DOIUrl":"10.1080/13697137.2024.2302967","url":null,"abstract":"Objectives: This study aimed to investigate the effect and the mechanism of recombinant human fibroblast growth factor 18 (rhFGF18) on postmenopausal osteoporosis.Methods: The effect of rhFGF18 on the proliferation and apoptosis of osteoblasts and the mechanism underlying such an effect was evaluated using an oxidative stress model of the MC3T3-E1 cell line. Furthermore, ovariectomy was performed on ICR mice to imitate estrogen-deficiency postmenopausal osteoporosis. Bone metabolism and bone morphological parameters in the ovariectomized (OVX) mice were evaluated.Results: The results obtained from the cell model showed that FGF18 promoted MC3T3-E1 cell proliferation by activating the extracellular signal-regulated kinase (ERK) and p38 instead of c-Jun N-terminal kinase (JNK). FGF18 also prevented cells from damage inflicted by oxidative stress via inhibition of apoptosis. After FGF18 administration, the expression level of anti-apoptotic protein Bcl-2 in the mice was upregulated, whereas those of the pro-apoptotic proteins Bax and caspase-3 were downregulated. Administering FGF18 also improved bone metabolism and bone morphological parameters in OVX mice.Conclusions: FGF18 could effectively prevent bone loss in OVX mice by enhancing osteoblastogenesis and protecting osteoblasts from oxidative stress-induced apoptosis.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"305-313"},"PeriodicalIF":2.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139563072","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resistance training effects on healthy postmenopausal women: a systematic review with meta-analysis. 阻力训练对绝经后健康妇女的影响：系统回顾与荟萃分析。

IF 2.9 4区医学

Climacteric Pub Date : 2024-06-01 Epub Date: 2024-02-14 DOI: 10.1080/13697137.2024.2310521

N González-Gálvez, J M Moreno-Torres, R Vaquero-Cristóbal

{"title":"Resistance training effects on healthy postmenopausal women: a systematic review with meta-analysis.","authors":"N González-Gálvez, J M Moreno-Torres, R Vaquero-Cristóbal","doi":"10.1080/13697137.2024.2310521","DOIUrl":"10.1080/13697137.2024.2310521","url":null,"abstract":"The aim of this systematic review with meta-analysis was to evaluate the effects of resistance training on physical fitness, physiological variables and body composition of postmenopausal women. The present systematic review was performed in accordance with the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement and was registered in PROSPERO. A total of 12 studies were included. The literature search was performed in PubMed, Web of Science and EBSCO. Randomized control trials were included. Two blinded investigators performed the search, study selection and data collection, and assessed the quality and risk of bias. A random-effects model was used for all analyses. Compared to the control group, resistance training produced a significant improvement in maximal oxygen volume (standardized mean difference [SMD] = 2.32, p < 0.001), lower extremity strength (SMD = 4.70, p < 0.001) and upper extremity strength (SMD = 7.42, p < 0.001). The results obtained in the systematic review and meta-analysis confirm the benefits of resistance training on physical fitness in postmenopausal women, although there is more debate regarding its influence on bone mineral density, and anthropometric and derived variables. This work provides a solid starting point for promoting resistance training at a frequency of 3 days per week, in 60-min sessions, with the aim of improving parameters directly related to quality of life, functionality and disease prevention of postmenopausal women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"296-304"},"PeriodicalIF":2.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139729125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genitourinary symptoms and sexual function in women with primary ovarian insufficiency. 原发性卵巢功能不全妇女的泌尿生殖系统症状和性功能。

IF 2.8 4区医学

Climacteric Pub Date : 2024-06-01 Epub Date: 2024-02-03 DOI: 10.1080/13697137.2024.2306278

J E Blümel, P Chedraui, M S Vallejo, M Dextre, A Elizalde, C Escalante, A Monterrosa-Castro, M Ñañez, E Ojeda, C Rey, D Rodríguez, M A Rodrigues, C Salinas, K Tserotas

{"title":"Genitourinary symptoms and sexual function in women with primary ovarian insufficiency.","authors":"J E Blümel, P Chedraui, M S Vallejo, M Dextre, A Elizalde, C Escalante, A Monterrosa-Castro, M Ñañez, E Ojeda, C Rey, D Rodríguez, M A Rodrigues, C Salinas, K Tserotas","doi":"10.1080/13697137.2024.2306278","DOIUrl":"10.1080/13697137.2024.2306278","url":null,"abstract":"Objective: There are limited studies on urogenital symptoms in women who experience menopause before the age of 40 years due to primary ovarian insufficiency (POI) or bilateral oophorectomy (surgical POI). This study aimed to compare the urogenital symptoms, including sexuality, of women with POI to those without the condition.Methods: This cross-sectional study conducted was in seven Latin American countries, in which postmenopausal women (with POI and non-POI) were surveyed with a general questionnaire, the Menopause Rating Scale (MRS) and the six-item Female Sexual Function Index (FSFI-6). The association of premature menopause with more urogenital symptoms and lower sexual function was evaluated with logistic regression analysis.Results: Women with POI experience more urogenital symptoms (MRS urogenital score: 3.54 ± 3.16 vs. 3.15 ± 2.89, p < 0.05) and have lower sexual function (total FSFI-6 score: 13.71 ± 7.55 vs. 14.77 ± 7.57 p < 0.05) than women who experience menopause at a normal age range. There were no significant differences in symptoms when comparing women based on the type of POI (idiopathic or surgical). After adjusting for covariates, our logistic regression model determined that POI is associated with more urogenital symptoms (odds ratio [OR]: 1.38, 95% confidence interval [CI] 1.06-1.80) and lower sexual function (OR: 1.67, 95% CI 1.25-2.25).Conclusion: POI, whether idiopathic or secondary to bilateral oophorectomy, is associated with symptoms that affect vaginal and sexual health.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"269-274"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139680747","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Genital chronic graft-versus-host disease: an unmet need that requires trained gynecologists. 生殖器慢性移植物抗宿主病：需要训练有素的妇科医生才能满足的需求。

IF 2.9 4区医学

Climacteric Pub Date : 2024-06-01 Epub Date: 2024-02-28 DOI: 10.1080/13697137.2024.2314521

M Á Martínez-Maestre, C Castelo-Branco, A M Calderón, I Espigado, J A Pérez-Simón, C González-Cejudo

{"title":"Genital chronic graft-versus-host disease: an unmet need that requires trained gynecologists.","authors":"M Á Martínez-Maestre, C Castelo-Branco, A M Calderón, I Espigado, J A Pérez-Simón, C González-Cejudo","doi":"10.1080/13697137.2024.2314521","DOIUrl":"10.1080/13697137.2024.2314521","url":null,"abstract":"Objective: Menopause and chronic graft-versus-host disease (cGvHD) are the leading causes of morbidity after allogeneic hematopoietic stem cell transplantation (alloHSCT). Genitalia are one of the target organs of cGvHD causing sexual dysfunction and local symptoms, which may impair women's quality of life. The aim of this study is to describe the prevalence and clinical characteristics of genital cGvHD.Methods: A retrospective cross-sectional observational study was performed including 85 women with alloHSCT. All women were diagnosed and counseled by a trained gynecologist. Health-related quality of life was assessed by the Cervantes Short-Form Scale and sexual function was evaluated by the Female Sexual Function Index.Results: Seventeen women (20%) included in the study were diagnosed with genital cGvHD. The main complaints were vulvovaginal dryness (42.2%) and dyspareunia (29.4%), the presence of erythema/erythematous plaques (52.9%) being the most frequent sign. Median time from transplant to diagnosis of genital cGvHD was 17 months among those with mild involvement, 25 months for moderate and 42 months for severe forms. Mortality was 29.4% in patients who developed cGvHD with genital involvement versus 8.8% among those without (p = 0.012).Conclusion: Early gynecological evaluation might allow to identify patients with mild forms of genital cGvHD, potentially enabling better management and improved outcomes.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"275-281"},"PeriodicalIF":2.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Impact of vaginal estriol on serum hormone levels: a systematic review. 阴道雌三醇对血清激素水平的影响：系统综述。

IF 2.8 4区医学

Climacteric Pub Date : 2024-04-01 Epub Date: 2024-01-02 DOI: 10.1080/13697137.2023.2287624

A Kolokythas, C Betschart, D Wunder, H Janka, P Stute

引用次数: 0

Prevalence of poor body image and its correlation with self-esteem and depression in middle-aged women. 中年女性身体形象不佳及其与自尊和抑郁的相关性。

IF 2.8 4区医学

Climacteric Pub Date : 2024-04-01 Epub Date: 2024-01-17 DOI: 10.1080/13697137.2023.2297876

R Satwik, D Sinha, B Tiwari

{"title":"Prevalence of poor body image and its correlation with self-esteem and depression in middle-aged women.","authors":"R Satwik, D Sinha, B Tiwari","doi":"10.1080/13697137.2023.2297876","DOIUrl":"10.1080/13697137.2023.2297876","url":null,"abstract":"Objective: This study aimed to determine the prevalence and predictors of poor body image and its influence on low self-esteem and depression in middle-aged women.Methods: The study was a cross-sectional survey of 372 women using a predesigned online questionnaire. Main outcome measures were mean scores on the nine-point body image scale (BIS) and prevalence of poor body image (BIS ≥ 10). Significant sociodemographic, physical and mental health predictors of BIS ≥ 10 were established using logistic regression analysis. Correlation of body image with self-esteem, assessed by Rosenberg's self-esteem scale, and depression, assessed by Beck's Depression Inventory, was established using Pearson's correlation coefficient and the odds ratios were determined using logistic regression analysis.Results: The mean scores obtained for body image were 5.52 (standard deviation 4.82) and the prevalence of BIS ≥ 10 was 17.4%. Significant predictors of poor body image were education status (0.59, 95% confidence interval [CI] = 0.39-0.89), body mass index (2.26, 95% CI = 1.12-4.55), social support structure (0.35, 95% CI = 0.16-0.79), diagnosis of mental illness (3.74, 95% CI = 1.31-10.66) and perception of menopause (positive vs. negative: 0.20, 95% CI = 0.07-0.55). Body image scores correlated with self-esteem (r = -0.46; 95% CI = -0.54 to -0.38) and depression (r = 0.59; 95% CI = 0.52-0.65). BIS ≥ 10 significantly increased the odds of low self-esteem (5.71; 95% CI = 2.66-12.26) and depression (11.25; 95% CI = 4.9-27.7).Conclusions: The prevalence of poor body image in middle-aged women was 17.4%. This strongly correlated with low self-esteem and depression. A lower education status, higher body mass index, a negative perception of menopause, poor social support structure and a history of mental health diagnosis increased the odds of poor body image prevalence in middle-aged women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"202-209"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139485165","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low thrombin generation in postmenopausal women using estetrol. 使用雌酮的绝经后妇女凝血酶生成量低。

IF 2.8 4区医学

Climacteric Pub Date : 2024-04-01 Epub Date: 2024-01-19 DOI: 10.1080/13697137.2023.2292066

L Morimont, M Didembourg, C Bouvy, M Jost, M Taziaux, Y Oligschlager, M van Rooijen, U Gaspard, J-M Foidart, J Douxfils

{"title":"Low thrombin generation in postmenopausal women using estetrol.","authors":"L Morimont, M Didembourg, C Bouvy, M Jost, M Taziaux, Y Oligschlager, M van Rooijen, U Gaspard, J-M Foidart, J Douxfils","doi":"10.1080/13697137.2023.2292066","DOIUrl":"10.1080/13697137.2023.2292066","url":null,"abstract":"Objective: Estetrol (E4) represents a novel estrogen of interest to relieve vasomotor symptoms. E4 activates the nuclear estrogen receptor α (ERα) but antagonizes the estradiol ERα-dependent membrane-initiated steroid signaling pathway. The distinct pharmacological properties of E4 could explain its low impact on hemostasis. This study aimed to assess the effect of E4 on coagulation in postmenopausal women, using the thrombin generation assay (TGA).Methods: Data were collected from a multicenter, randomized, placebo-controlled, dose-finding study in postmenopausal women (NCT02834312). Oral E4 (2.5 mg, n = 42; 5 mg, n = 29; 10 mg, n = 34; or 15 mg, n = 32) or placebo (n = 31) was administered daily for 12 weeks. Thrombograms and TGA parameters were extracted for each subject at baseline and after 12 weeks of treatment.Results: After 12 weeks of treatment, all treatment groups showed a mean thrombogram (±95% confidence interval [CI] of the mean) within the reference ranges, that is, the 2.5th-97.5th percentile of all baseline thrombograms (n = 168), as well as for TGA parameters.Conclusions: The intake of E4 15 mg for 12 weeks led to significant but not clinically relevant changes compared to baseline as the mean values (±95% CI of the mean) remained within reference ranges, demonstrating a neutral profile of this estrogen on hemostasis.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"193-201"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139490621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Obesity and sexual health: focus on postmenopausal women. 肥胖与性健康：关注绝经后妇女。

IF 2.8 4区医学

Climacteric Pub Date : 2024-04-01 Epub Date: 2024-01-22 DOI: 10.1080/13697137.2024.2302429

F Barbagallo, L Cucinella, L Tiranini, P Chedraui, A E Calogero, R E Nappi

{"title":"Obesity and sexual health: focus on postmenopausal women.","authors":"F Barbagallo, L Cucinella, L Tiranini, P Chedraui, A E Calogero, R E Nappi","doi":"10.1080/13697137.2024.2302429","DOIUrl":"10.1080/13697137.2024.2302429","url":null,"abstract":"Menopause is a cardiometabolic transition with many women experiencing weight gain and redistribution of body fat. Hormonal changes may affect also several dimensions of well-being, including sexual function, with a high rate of female sexual dysfunction (FSD), which displays a multifactorial etiology. The most important biological factors range from chronic low-grade inflammation, associated with hypertrophic adipocytes that may translate into endothelial dysfunction and compromised blood flow through the genitourinary system, to insulin resistance and other neuroendocrine mechanisms targeting the sexual response. Psychosocial factors include poor body image, mood disorders, low self-esteem and life satisfaction, as well as partner's health and quality of relationship, and social stigma. Even unhealthy lifestyle, chronic conditions and putative weight-promoting medications may play a role. The aim of the present narrative review is to update and summarize the state of the art on the link between obesity and FSD in postmenopausal women, pointing to the paucity of high-quality studies and the need for further research with validated end points to assess both biomarkers of obesity and FSD. In addition, we provide general information on the diagnosis and treatment of FSD at menopause with a focus on dietary interventions, physical activity, anti-obesity drugs and bariatric surgery.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"122-136"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139511768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Arthralgia in midlife Singaporean women: the Integrated Women's Health Program (IWHP). 新加坡中年妇女的关节痛：综合妇女健康计划（IWHP）。

IF 2.8 4区医学

Climacteric Pub Date : 2024-04-01 Epub Date: 2023-12-15 DOI: 10.1080/13697137.2023.2287626

B W X Wong, Y H Chan, S Logan, M S Kramer, E L Yong

{"title":"Arthralgia in midlife Singaporean women: the Integrated Women's Health Program (IWHP).","authors":"B W X Wong, Y H Chan, S Logan, M S Kramer, E L Yong","doi":"10.1080/13697137.2023.2287626","DOIUrl":"10.1080/13697137.2023.2287626","url":null,"abstract":"Objective: Arthralgia is a common menopausal complaint in midlife women, and its causes remain unclear. We examined the prevalence of menopausal arthralgia with various factors including sleep quality, depression/anxiety, muscle strength and physical performance among midlife Singaporean women.Methods: The Integrated Women's Health Program (IWHP) comprised 1120 healthy, community-dwelling women of Chinese, Malay or Indian ethnicities (aged 45-69 years) attending well-women clinics at the National University Hospital, Singapore. Sociodemographic, menopausal, reproductive and health data were obtained with validated questionnaires. Muscle strength, physical performance and dual-energy X-ray absorptiometry were measured. Women with moderate to very severe symptoms using the Menopause Rating Scale were classified as having arthralgia. Multivariable logistic regression analyses examined risk factors for arthralgia.Results: One-third of the participants reported arthralgia, and 12.7%, 16.2% and 71.2% were in the premenopausal, perimenopausal and postmenopausal period, respectively. Menopausal symptoms, such as vaginal dryness (adjusted odds ratio [aOR]: 2.64, 95% confidence interval [CI]: 1.64, 4.24) and physical/mental exhaustion (aOR: 2.83, 95% CI: 1.79, 4.47), were independent risk factors for arthralgia. Poor muscle strength (aOR: 2.20, 95% CI: 1.29, 3.76), obesity (aOR: 1.94, 95% CI: 1.13, 3.32) and rheumatoid arthritis (aOR: 7.73, 95% CI: 4.47, 13.36) were also independently associated with arthralgia after adjustment for confounders.Conclusions: Arthralgia in midlife Singaporean women was associated with menopausal symptoms of vaginal dryness and physical and mental exhaustion. Women with poor muscle strength were more likely to experience menopausal arthralgia.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"178-186"},"PeriodicalIF":2.8,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138799367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The next chapter. 下一章

IF 2.8 4区医学

Climacteric Pub Date : 2024-04-01 Epub Date: 2024-03-12 DOI: 10.1080/13697137.2024.2319513

Tim Hillard

引用次数: 0