Climacteric最新文献

{"title":"Peer reviewers for <i>Climacteric</i> in 2024.","authors":"","doi":"10.1080/13697137.2025.2459539","DOIUrl":"https://doi.org/10.1080/13697137.2025.2459539","url":null,"abstract":"","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":"28 2","pages":"ei"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143728999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Unraveling sleep quality in menopausal women: objective assessments and self-reported experiences - a mini-review.","authors":"Lixia Wang, Yi Xiao, Min Luo, Rong Huang","doi":"10.1080/13697137.2025.2470450","DOIUrl":"10.1080/13697137.2025.2470450","url":null,"abstract":"<p><p>Sleep is a cornerstone of health, playing an integral role in both physiological and psychological functions. However, it is vulnerable to a variety of factors including menopause. According to available research, the onset of the menopause transition may not necessarily worsen sleep architecture and could even enhance it, leading to conflict between assessment of subjective and objective sleep complaints. This discrepancy highlights the complex relationship between subjective and objective sleep quality. Understanding this relationship remains challenging due to the limited number of longitudinal studies and small sample sizes. This review explores findings from both subjective and objective sleep assessments in menopausal women and examines the impact of menopausal hormone therapy on sleep quality.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"104-114"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143604254","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treating VVA improves symptom severity and patient-reported outcomes: 6-month PEONY results.","authors":"Rossella E Nappi, Maria Cristina Meriggiola, Francesca Albani, Gloria Bonaccorsi, Giovanni Delli Carpini, Alessandro Gambera, Silvia Marsini, Antonio Nicolucci, Maria Chiara Rossi, Valentina Trionfera, Paola Villa","doi":"10.1080/13697137.2025.2455167","DOIUrl":"10.1080/13697137.2025.2455167","url":null,"abstract":"<p><strong>Objective: </strong>The real-world PatiEnt satisfactiON studY (PEONY) involves postmenopausal women already treated or starting local estrogen therapy (LET) or ospemifene. The aim of the present analysis was to assess treatment satisfaction and persistence, effectiveness and patient-reported outcomes (PROs) in sexual function and quality of life after 6 months of therapy with LET or ospemifene to treat vulvovaginal atrophy (VVA).</p><p><strong>Methods: </strong>PEONY is an ongoing prospective, observational study conducted in 17 gynecology centers. Participants complete questionnaires at baseline (T0) and after 3 months (T3) and 6 months (T6). The main outcome measures were treatment satisfaction, severity of symptoms, Day-to-Day Impact of Vaginal Aging (DIVA), Female Sexual Function Index (FSFI), Female Sexual Distress Scale - Revised (FSDS-R) and SF-12 Health Survey.</p><p><strong>Results: </strong>Overall, 385 women were included, of whom 145 started (87.6%) or continued (12.4%) ospemifene and 240 started (66.7%) or continued (33.3%) LET at T0. The likelihood of moderate/severe VVA symptoms decreased by 70-90% and the mean treatment satisfaction score increased overall from 7.3 (95% confidence interval [CI]: 7.0; 7.5) at T3 to 7.7 (95% CI: 7.4; 7.9) at T6 (<i>p</i> = 0.003). DIVA and FSDS-R scores significantly improved in both groups.</p><p><strong>Conclusions: </strong>PEONY underlines the importance of proactively treating VVA with LET or ospemifene to alleviate the burden associated with the disease.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"115-125"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Flaxseed and mulberry extract improve trabecular bone quality in estrogen-deficient rats.","authors":"Larissa Sampaio Jacques, Jéssica Petrine Castro Pereira, Beatriz Menegate Santos, Breno Rocha Barrioni, Bruno Del Bianco Borges","doi":"10.1080/13697137.2025.2457988","DOIUrl":"10.1080/13697137.2025.2457988","url":null,"abstract":"<p><p>Many hormones, including estrogens, modulate bone metabolism, which plays a crucial role in maintaining bone health. Estrogen depletion, as occurs in menopause, leads to increased bone resorption and decreased formation, resulting in osteopenia/osteoporosis. This study investigates the effects of flaxseed (<i>Linum usitatissimum</i>) and mulberry (<i>Morus nigra</i> L.) extracts, known for their phenolic compounds and antioxidant properties, against estrogen deficiency-induced bone loss in female Wistar rats. These extracts were administered to ovariectomized rats for 60 days. High-performance liquid chromatography analysis revealed the presence of some phenolic compounds in the extracts, including trigonelline, gallic acid, theobromine, chlorogenic acid, syringic acid and <i>p</i>-coumaric acid. The extracts improved bone microstructure with higher trabecular bone, bone mineral density, calcium, phosphorus and magnesium levels, and lower porosity and intertrabecular space in bone tissue. Furthermore, plasma alkaline phosphatase activity was elevated in extract-treated animals, indicating enhanced bone tissue formation. Although serum carboxy-terminal fragment levels showed no significant change, the data suggest that flaxseed and mulberry extracts may protect against trabecular bone loss and support bone formation in estrogen-deficient conditions. These results suggest that supplementing these natural extracts holds promise in preventing or alleviating the signs and symptoms associated with estrogenic deficiency.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"175-183"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Relationship between insulin resistance surrogates and bone mineral density in postmenopausal women.","authors":"Min Li, Lei Gao, Ying Liu, Yongli Zheng, Luyao Chen, Yan Wang, Wei Zhang","doi":"10.1080/13697137.2025.2455164","DOIUrl":"10.1080/13697137.2025.2455164","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the association between four insulin resistance (IR) surrogates and bone mineral density (BMD) and whether IR surrogates could be risk factors for osteoporosis (OP) in Chinese non-diabetic postmenopausal individuals.</p><p><strong>Methods: </strong>Four non-insulin-based surrogates including triglyceride glucose (TyG), triglyceride glucose with body mass index (TyG-BMI), triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C) and the metabolic score for insulin resistance (METS-IR) index were calculated. All individuals underwent dual-energy X-ray absorptiometry for measurement of BMD. Pearson correlation analysis was employed to evaluate the correlations between IR indices and BMD. Subsequently, logistic regression analysis was performed to investigate the relationship between these indices and OP while the receiver-operating characteristic curve was used to assess the predictive values for OP.</p><p><strong>Results: </strong>Both TyG-BMI and the METS-IR index were significantly positively associated with BMD. As TyG-BMI and the METS-IR index increased, the prevalence of OP decreased. After adjusting confounding factors, the fourth quartile of TyG-BMI and the METS-IR index showed significantly decreased odds ratio of 0.304 and 0.352, respectively, for OP with respect to its first quartile value. The area under the curve of TyG-BMI and the METS-IR index was 0.616 and 0.605, respectively.</p><p><strong>Conclusions: </strong>IR surrogates TyG-BMI and the METS-IR index were positively associated with BMD and may be protective factors for OP in Chinese non-diabetic postmenopausal women.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"154-161"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Influence of estradiol deficiency on the mineralocorticoid receptor response in postmenopausal women: a cross-sectional study.","authors":"Alejandra Martínez-García, Jorge A Pérez, Alejandra Tapia-Castillo, María P Hernández, Marlin Solórzano, Pablo Carrión, Carlos E Fardella, Cristian A Carvajal","doi":"10.1080/13697137.2025.2455181","DOIUrl":"10.1080/13697137.2025.2455181","url":null,"abstract":"<p><strong>Objective: </strong>Premenopausal women (PreM) have a cardioprotective advantage over postmenopausal women (PostM) due to estrogen. The interaction of estrogen with the mineralocorticoid receptor (MR) pathway remains unexplored. This study aimed to identify changes in aldosterone, renin and sexual steroid levels and MR surrogate biomarkers in PostM that may explain changes in blood pressure and renal damage.</p><p><strong>Methods: </strong>A cross-sectional study was carried out with 47 normotensive and hypertensive Chilean women distributed between PreM and PostM. Clinical, anthropometric and biochemical parameters, including aldosterone, plasma renin activity (PRA) and surrogate markers of MR activity, were assessed.</p><p><strong>Results: </strong>PostM had greater systolic blood pressure (SBP) (<i>p</i> < 0.001) than PreM. A negative correlation was observed between estradiol and fractional excretion of potassium (FEK) (<i>ρ</i> = -0.29; <i>p</i> = 0.023), adjusted for age and SBP. Compared with hypertensive PreM, hypertensive PostM (PostM-HT) showed reduced PRA (<i>p</i> = 0.045) and greater FEK (<i>p</i> = 0.04). Normotensive PostM (Post-NT) exhibited greater SBP (<i>p</i> = 0.03), neutrophil gelatinase-associated lipocalin (NGAL) levels (<i>p</i> = 0.04) and FEK (<i>p</i> = 0.03) than normotensive PreM.</p><p><strong>Conclusion: </strong>Our results suggest enhanced MR sensitivity not only in PostM-HT, as evidenced by lower PRA and elevated FEK, but also in PostM-NT, who exhibited greater FEK and NGAL levels, surrogate markers of MR activation. These results support a novel role of MR activation and cardiovascular risk in PostM women.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"162-168"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concentration and genetic regulation of sex hormone binding globulin and fracture risk in older women.","authors":"Yuanyuan Wang, Chenglong Yu, Rakibul M Islam, Sultana Monira Hussain, Anna L Barker, Paul Lacaze, John J McNeil, Susan R Davis","doi":"10.1080/13697137.2024.2431036","DOIUrl":"10.1080/13697137.2024.2431036","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the association between concentrations of sex hormone binding globulin (SHBG) and fracture risk in community-dwelling older women and explore whether this was explained by the genetic regulation of SHBG.</p><p><strong>Methods: </strong>This prospective cohort study examined 4871 women aged ≥70 years who were not taking medications influencing SHBG concentrations. A genome-wide association study was undertaken to identify single nucleotide polymorphisms (SNPs) associated with SHBG concentrations. Incident fracture was confirmed by medical imaging and adjudicated by expert review committee.</p><p><strong>Results: </strong>The median age of participants was 74.0 years. Over 3.9 (standard deviation 1.4) years of follow-up, 484 participants had an incident fracture. There was a linear trend for a positive association between SHBG concentrations and fracture risk (<i>p</i> = 0.001), with the highest SHBG quartile associated with a significantly greater fracture risk compared with the lowest quartile (hazard ratio 1.54, 95% confidence interval 1.16-2.04, <i>p</i> = 0.003), adjusting for age, body mass index, alcohol consumption, smoking, diabetes, impaired renal function, treatment allocation, medications affecting bone and high-density lipoprotein cholesterol. Two independent SNPs were associated with SHBG concentrations, rs10822163 and rs727428, but neither was associated with fracture risk.</p><p><strong>Conclusion: </strong>SHBG concentrations were positively associated with a greater fracture risk in community-dwelling women aged ≥70 years, which was not explained by genetic variants associated with SHBG regulation.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"184-190"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intravenous administration of mitochondria improves ovarian function by anti-apoptosis in the premature ovarian insufficiency model.","authors":"Han-Lin Yang, Yuan-Mei Wang, Qing Li, Hao Luo, Jun Tan, Xing Zhao, Dan Zi","doi":"10.1080/13697137.2024.2441248","DOIUrl":"10.1080/13697137.2024.2441248","url":null,"abstract":"<p><strong>Objective: </strong>For patients with contraindications to hormone therapy, the absence of effective treatments for ovarian dysfunction post chemotherapy represents a critical issue requiring resolution. Local administration of mitochondria may enhance ovarian function in premature ovarian insufficiency (POI) by ameliorating diminished mitochondrial activity. Nevertheless, there is a paucity of literature on the efficacy of mitochondrial transplantation through intravenous injection, a less invasive and more convenient method than local injection, for the improvement of ovarian function in POI following chemotherapy.</p><p><strong>Method: </strong>Mitochondria were isolated from mouse livers, their activity and integrity were validated with MitoTracker Red and their localization was examined via confocal microscopy, real-time quantitative PCR and enzyme-linked immunosorbent assay post tail vein injection. An ovarian insufficiency animal model induced by chemotherapy was developed, and ovarian function was assessed through ovarian diameter, vaginal smear, body weight, sex hormone levels and histological analysis. The impact of mitochondrial transplantation on an ovarian cell model was examined through the assessment of mitochondrial function, apoptosis and levels of reactive oxygen species.</p><p><strong>Conclusion: </strong>Tail vein injection of isolated mitochondria has the potential to enhance ovarian functions in an animal model of POI induced by cyclophosphamide, increase mitochondrial activity in impaired ovarian cells and decrease the rate of apoptosis.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"200-211"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of aerobic and resistance training on bone, muscle hypertrophy and inflammation in OVX mice.","authors":"Luciana Botelho Ribeiro, Pedro Gustavo Machado, Juliana Cristina Reis-Canaan, Ivam Moreira de Oliveira Júnior, Natália Oliveira Bertolini, Soraia Macari, Cândido Celso Coimbra, Luciano José Pereira","doi":"10.1080/13697137.2025.2471059","DOIUrl":"https://doi.org/10.1080/13697137.2025.2471059","url":null,"abstract":"<p><strong>Objective: </strong>Bone loss is common with aging, particularly due to reduced sex hormones, as seen in menopause. While physical training is a known non-pharmacological therapy for osteopenia and sarcopenia, few studies compare resistance and aerobic protocols, especially with systemic inflammatory markers. This study evaluated the effects of aerobic and resistance training on physical performance, femoral trabecular bone quality (micro-computed tomography), serum inflammatory markers (IL-1β, IL-6, TNF-α, IL-10) and gastrocnemius muscle area in ovariectomized (OVX) female mice.</p><p><strong>Method: </strong>Sixty-four c57bl/6 mice were divided into OVX and SHAM groups and subjected to sedentary, resistance (climbing) or aerobic (treadmill) protocols for 8 weeks.</p><p><strong>Results: </strong>Training reduced body mass (<i>p</i> < 0.001) in trained animals compared to sedentary. Bone quality was higher in trained groups versus sedentary. OVX increased TNF-α, but training did not alter it. IL-1β levels were higher in climbing than treadmill groups, and IL-6 increased with OVX and aerobic training (<i>p</i> < 0.001). IL-10 was elevated in the SHAM and climbing groups (<i>p</i> < 0.01). Gastrocnemius muscle area increased in both trained groups (<i>p</i> < 0.001) with no differences between modalities.</p><p><strong>Conclusion: </strong>Aerobic and resistance training improved bone quality and muscle area in OVX mice, with climbing training uniquely linked to increased IL-10 levels.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From waste to wellness - what women want: insights into patient perspectives on topical vaginal estrogen applicators and environmental considerations.","authors":"Ana Sofia Da Silva, Miriam O'Kane, Cathy Davis, Angie Rantell, George Araklitis, Dudley Robinson","doi":"10.1080/13697137.2025.2473431","DOIUrl":"https://doi.org/10.1080/13697137.2025.2473431","url":null,"abstract":"<p><strong>Objective: </strong>Environmental consciousness and the role of plastic waste are increasing. Topical vaginal estrogen prescription can be prescribed with one reusable plastic applicator or multiple single-use plastic applicators. User preference about the role of plastic in personal healthcare is not fully understood. This study aimed to explore patients' perspectives on the applicator and environmental considerations.</p><p><strong>Method: </strong>A mixed-methods questionnaire was employed to assess users' experience with topical vaginal estrogen applicators and their views on the environment.</p><p><strong>Results: </strong>Ninety-two respondents had previously used estriol 0.1% cream and 77 had used estradiol 10 μg vaginal inserts. The mean age of participants was 67.3 years. The mean duration of use was 36.5 months, and the discontinuation rate was 26.1% and 29.9% for estriol 0.1% cream and estradiol 10 μg vaginal insert users, respectively. Satisfaction with applicators and ease of use were similar in both groups. There was a higher report of the product being 'messy' (38.0% vs. 18.2%; <i>p</i> = 0.026) and 'not hygienic' (48.9% vs. 18.2%; <i>p</i> < 0.001) by estriol 0.1% cream users compared to estradiol 10 μg vaginal insert users. Women aged <65 years demonstrated a greater concern about plastic use and the impact on the environment compared to women aged over 65 years (81.0% vs. 56.9%; <i>p</i> = 0.002). The younger cohort showed a preference for reusable applicators (66.2%) compared to single-use applicators (33.8%) (<i>p =</i> 0.005). There was no statistically significant difference in preference for women aged over 65 years.</p><p><strong>Conclusion: </strong>This study demonstrates that younger postmenopausal women showed greater concern for plastic waste and its impact on the environment, with a preference for reusable products. Manufacturers of health products and prescribers should be aware of this growing trend. With similar overall satisfaction and side-effect profiles, users should be made aware of the different types of applicators available to help support an informed decision.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}