Investigating the triglyceride-glucose index in postmenopausal osteoporosis.

IF 2.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY

Climacteric Pub Date : 2025-02-01 Epub Date: 2024-12-05 DOI:10.1080/13697137.2024.2429430

Busra Korpe, Caner Kose, Sumeyye Mermi, Samet Kutluay Ergorun, Huseyin Levent Keskin

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引用次数: 0

Abstract

Objective: This retrospective study aims to assess the association of the triglyceride-glucose index (TyG index) with postmenopausal osteoporosis and investigate longitudinal changes in TyG index levels in relation to osteoporosis risk.

Methods: Out of 704 women, after excluding those with osteopenia, a total of 517 patients who met the inclusion criteria were included. Participants were categorized based on T-scores derived from lumbar spine dual-energy X-ray absorptiometry scans. Demographic data, biochemical parameters and TyG index levels were analyzed. Logistic regression, correlation analysis and receiver operating characteristic (ROC) curve analysis were employed for statistical evaluation.

Results: The osteoporosis group (n = 254) exhibited significantly higher TyG index and triglyceride levels compared to controls (n = 263). Longitudinal analysis revealed significant increases in TyG index levels among women developing osteoporosis over time. ROC analysis demonstrated the TyG index's accuracy for osteoporosis (first TyG area under the curve [AUC]: 0.767, second TyG AUC: 0.818, p < 0.001). Regression analyses identified the TyG index as a significant factor associated with osteoporosis (odds ratio: 39.468, 95% confidence interval: 12.884-120.903, p < 0.001).

Conclusions: The TyG index emerges as a valuable indicator for postmenopausal osteoporosis. These results emphasize the need for integrating metabolic health indicators into osteoporosis management strategies, warranting further research into targeted interventions.

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绝经后骨质疏松症患者甘油三酯-葡萄糖指数的研究。

目的：本回顾性研究旨在评估甘油三酯-葡萄糖指数（TyG指数）与绝经后骨质疏松症的关系，并探讨TyG指数水平的纵向变化与骨质疏松症风险的关系。方法：704名女性中，剔除骨质减少者后，共纳入517例符合纳入标准的患者。根据腰椎双能x线吸收仪扫描得出的t评分对参与者进行分类。统计学资料、生化指标及TyG指数水平分析。采用Logistic回归、相关分析和受试者工作特征（ROC）曲线分析进行统计评价。结果：骨质疏松组（n = 254）的TyG指数和甘油三酯水平明显高于对照组（n = 263）。纵向分析显示，随着时间的推移，患骨质疏松症的女性TyG指数水平显著增加。ROC分析显示TyG指数对骨质疏松症的准确性（第一次TyG曲线下面积[AUC]: 0.767，第二次TyG曲线下面积：0.818,p p）。结论：TyG指数是绝经后骨质疏松症的一个有价值的指标。这些结果强调了将代谢健康指标纳入骨质疏松症管理策略的必要性，值得进一步研究有针对性的干预措施。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.