Climacteric最新文献

Knowledge and attitudes of premenopausal women in southern China toward menopause and menopausal hormone therapy.

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-07 DOI: 10.1080/13697137.2025.2455168

Yan Zhang, Xiujuan Chen, Yuan Lin, Xiaoqing Liu, Xiumei Xiong

{"title":"Knowledge and attitudes of premenopausal women in southern China toward menopause and menopausal hormone therapy.","authors":"Yan Zhang, Xiujuan Chen, Yuan Lin, Xiaoqing Liu, Xiumei Xiong","doi":"10.1080/13697137.2025.2455168","DOIUrl":"https://doi.org/10.1080/13697137.2025.2455168","url":null,"abstract":"Objective: Menopause is a significant and natural phase in a woman's life, representing a transition that requires early understanding to manage its effects and promote overall well-being. This study aimed to evaluate the awareness, understanding and perceptions of menopause and menopausal hormone therapy (MHT) among premenopausal women in southern China.Methods: A cross-sectional design was employed to enroll women aged 18-40 years (n = 1631) from August 2022 to January 2023 at a public hospital in Fujian, China. A structured questionnaire, developed from existing research and the Climacteric Scale, was used to assess women's menopausal symptoms and MHT knowledge. Face-to-face interviews were conducted to identify factors correlated with menopausal knowledge levels.Results: More than 50% of women demonstrated a comprehensive understanding of menopause. Education level was a significant predictor of menopause knowledge (p < 0.001), with women holding higher education (college degree or above) demonstrating greater knowledge than those with lower education (high school or below). High awareness of common menopausal symptoms, including irritability, sleep disturbances, fatigue, difficulty concentrating and hot flashes, was observed. Although most participants lacked detailed knowledge of MHT, they agreed on the importance of managing menopausal symptoms and recognized the usefulness of MHT for symptom management.Conclusions: Premenopausal women in southern China possess a basic understanding of menopause but lack sufficient knowledge about MHT. This highlights the need for educational initiatives and targeted counseling to increase awareness of menopause and MHT, especially regarding its implications and treatment options.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-9"},"PeriodicalIF":2.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Treating VVA improves symptom severity and patient-reported outcomes: 6-month PEONY results.

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-07 DOI: 10.1080/13697137.2025.2455167

Rossella E Nappi, Maria Cristina Meriggiola, Francesca Albani, Gloria Bonaccorsi, Giovanni Delli Carpini, Alessandro Gambera, Silvia Marsini, Antonio Nicolucci, Maria Chiara Rossi, Valentina Trionfera, Paola Villa

{"title":"Treating VVA improves symptom severity and patient-reported outcomes: 6-month PEONY results.","authors":"Rossella E Nappi, Maria Cristina Meriggiola, Francesca Albani, Gloria Bonaccorsi, Giovanni Delli Carpini, Alessandro Gambera, Silvia Marsini, Antonio Nicolucci, Maria Chiara Rossi, Valentina Trionfera, Paola Villa","doi":"10.1080/13697137.2025.2455167","DOIUrl":"https://doi.org/10.1080/13697137.2025.2455167","url":null,"abstract":"Objective: The real-world PatiEnt satisfactiON studY (PEONY) involves postmenopausal women already treated or starting local estrogen therapy (LET) or ospemifene. The aim of the present analysis was to assess treatment satisfaction and persistence, effectiveness and patient-reported outcomes (PROs) in sexual function and quality of life after 6 months of therapy with LET or ospemifene to treat vulvovaginal atrophy (VVA).Methods: PEONY is an ongoing prospective, observational study conducted in 17 gynecology centers. Participants complete questionnaires at baseline (T0) and after 3 months (T3) and 6 months (T6). The main outcome measures were treatment satisfaction, severity of symptoms, Day-to-Day Impact of Vaginal Aging (DIVA), Female Sexual Function Index (FSFI), Female Sexual Distress Scale - Revised (FSDS-R) and SF-12 Health Survey.Results: Overall, 385 women were included, of whom 145 started (87.6%) or continued (12.4%) ospemifene and 240 started (66.7%) or continued (33.3%) LET at T0. The likelihood of moderate/severe VVA symptoms decreased by 70-90% and the mean treatment satisfaction score increased overall from 7.3 (95% confidence interval [CI]: 7.0; 7.5) at T3 to 7.7 (95% CI: 7.4; 7.9) at T6 (p = 0.003). DIVA and FSDS-R scores significantly improved in both groups.Conclusions: PEONY underlines the importance of proactively treating VVA with LET or ospemifene to alleviate the burden associated with the disease.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-11"},"PeriodicalIF":2.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical management of obesity: unlocking the potential.

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-07 DOI: 10.1080/13697137.2025.2455177

Angie S Xiang, Priya Sumithran

引用次数: 0

Vaginal oxygen plus hyaluronic acid on lower urinary tract symptoms in breast cancer survivors.

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-04 DOI: 10.1080/13697137.2025.2455182

Giorgia Asinaro, Claudia Massarotti, Valentina Musante, Marta Fiamberti, Beatrice Marchese, Matteo Lambertini, Lucia Del Mastro, Ambrogio P Londero, Angelo Cagnacci

{"title":"Vaginal oxygen plus hyaluronic acid on lower urinary tract symptoms in breast cancer survivors.","authors":"Giorgia Asinaro, Claudia Massarotti, Valentina Musante, Marta Fiamberti, Beatrice Marchese, Matteo Lambertini, Lucia Del Mastro, Ambrogio P Londero, Angelo Cagnacci","doi":"10.1080/13697137.2025.2455182","DOIUrl":"https://doi.org/10.1080/13697137.2025.2455182","url":null,"abstract":"Objective: This study aimed to evaluate the effect of vaginal oxygen and hyaluronic acid on lower urinary tract symptoms (LUTS) in breast cancer survivors.Method: A prospective trial was conducted at a university hospital's Menopause Outpatient Clinic. Breast cancer patients experiencing LUTS received intravaginal natural oxygen for 15 min, coupled with a 2% hyaluronic acid solution during the last 5 min. This treatment was performed five times at 15-day intervals. Assessments were repeated at each application and 60 days after the last application. Scores on the Urogenital Distress Inventory-6 (UDI-6) short form and its single items assessing different LUTS aspects were determined.Results: Treatment in 85 breast cancer patients decreased the UDI-6 total score (from 24.8 ± 19.9 to 17.5 ± 16.2; p < 0.001) and subscales evaluating irritative (p = 0.001), stress (p = 0.006) and obstructive discomfort (p = 0.001) symptoms. In multivariate analysis, aromatase inhibitors were independently associated with a greater improvement of LUTS (coefficient of regression [CR] - 8.05, 95% confidence interval [CI] -13.41, -2.64; p = 0.004)). The use of a gonadotrophin-releasing hormone (GnRH) analog was associated with a greater improvement of irritative symptoms (CR -2.42, 95% CI -4.75, -0.08; p = 0.042), while tamoxifen reduced the improvement of stress symptoms (CR 2.49, 95% CI 0.10, 4.90; p = 0.041).Conclusion: Short-term treatment with vaginal oxygen and hyaluronic acid appeared to improve LUTS of breast cancer patients.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-6"},"PeriodicalIF":2.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between insulin resistance surrogates and bone mineral density in postmenopausal women.

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-04 DOI: 10.1080/13697137.2025.2455164

Min Li, Lei Gao, Ying Liu, Yongli Zheng, Luyao Chen, Yan Wang, Wei Zhang

{"title":"Relationship between insulin resistance surrogates and bone mineral density in postmenopausal women.","authors":"Min Li, Lei Gao, Ying Liu, Yongli Zheng, Luyao Chen, Yan Wang, Wei Zhang","doi":"10.1080/13697137.2025.2455164","DOIUrl":"https://doi.org/10.1080/13697137.2025.2455164","url":null,"abstract":"Objective: This study aimed to investigate the association between four insulin resistance (IR) surrogates and bone mineral density (BMD) and whether IR surrogates could be risk factors for osteoporosis (OP) in Chinese non-diabetic postmenopausal individuals.Methods: Four non-insulin-based surrogates including triglyceride glucose (TyG), triglyceride glucose with body mass index (TyG-BMI), triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C) and the metabolic score for insulin resistance (METS-IR) index were calculated. All individuals underwent dual-energy X-ray absorptiometry for measurement of BMD. Pearson correlation analysis was employed to evaluate the correlations between IR indices and BMD. Subsequently, logistic regression analysis was performed to investigate the relationship between these indices and OP while the receiver-operating characteristic curve was used to assess the predictive values for OP.Results: Both TyG-BMI and the METS-IR index were significantly positively associated with BMD. As TyG-BMI and the METS-IR index increased, the prevalence of OP decreased. After adjusting confounding factors, the fourth quartile of TyG-BMI and the METS-IR index showed significantly decreased odds ratio of 0.304 and 0.352, respectively, for OP with respect to its first quartile value. The area under the curve of TyG-BMI and the METS-IR index was 0.616 and 0.605, respectively.Conclusions: IR surrogates TyG-BMI and the METS-IR index were positively associated with BMD and may be protective factors for OP in Chinese non-diabetic postmenopausal women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Understanding the menopause journey.

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-04 DOI: 10.1080/13697137.2024.2445303

Nanette Santoro

{"title":"Understanding the menopause journey.","authors":"Nanette Santoro","doi":"10.1080/13697137.2024.2445303","DOIUrl":"https://doi.org/10.1080/13697137.2024.2445303","url":null,"abstract":"The menopause experience is unique to people with ovaries who attain an age at which functioning follicles are depleted. Unlike male reproductive aging, menopause is accompanied by a definable reproductive milestone in that menstrual periods cease and the failure of follicle growth results in a large drop in circulating estrogen and no further ovarian production of progesterone. While the focus on menopause has largely been centered on this absence of hormone production, the most dynamic changes in symptoms and health markers begin before the final menstrual period, and merit attention. Vasomotor symptoms, the most common symptom of menopause and the primary symptom that drives women to seek treatment, peak in frequency and prevalence in the late menopause transition, when women are still having menstrual periods. Body composition and adverse lipoprotein and lipid changes also worsen most acutely in the late transition, and then assume a slower, age-related trajectory of change. Multiple processes that worsen across the transition restabilize after it is over. The notion that the menopause transition is an adaptive process for women has scientific merit and suggests that facilitating this adaptation and recognizing its implications may represent the next phase of progress in the field.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-5"},"PeriodicalIF":2.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Corneal thickness, contrast sensitivity and binocular vision in menopausal and non-menopausal women. 绝经期和非绝经期妇女的角膜厚度、对比敏感度和双眼视力。

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-01 Epub Date: 2024-12-18 DOI: 10.1080/13697137.2024.2438733

Hemn Baghban Jaldian, Ali Mirzajani, Rasoul Amini Vishteh, Jamileh Abolghasemi, Parva Pourbagherkhah

引用次数: 0

Monique Boulet: 30 March 1938 - 26 March 2024.

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-01 Epub Date: 2024-12-06 DOI: 10.1080/13697137.2024.2436832

Tim Hillard, Wulf Utian, Hermann Schneider

引用次数: 0

Cut-off point development for the Everyday Memory Questionnaire - Revised in perimenopausal women. 围绝经期妇女日常记忆力问卷--修订版的临界点开发。

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-01 Epub Date: 2024-09-26 DOI: 10.1080/13697137.2024.2401369

Chen Zhu, Elizabeth H X Thomas, Qi Li, Shalini Arunogiri, Caroline Gurvich

{"title":"Cut-off point development for the Everyday Memory Questionnaire - Revised in perimenopausal women.","authors":"Chen Zhu, Elizabeth H X Thomas, Qi Li, Shalini Arunogiri, Caroline Gurvich","doi":"10.1080/13697137.2024.2401369","DOIUrl":"10.1080/13697137.2024.2401369","url":null,"abstract":"Objective: Subjective cognitive complaints have been reported in women during perimenopause and the Everyday Memory Questionnaire - Revised (EMQ-R) has been recently evaluated as a standardized instrument to measure subjective cognitive changes. The purpose of this study was to identify potential cut-off points for the EMQ-R retrieval subscale and attentional subscale, and to assess the validity of these cut-off points in detecting objective cognitive changes associated with reported subjective cognitive complaints.Method: After screening, 232 perimenopausal women were included in the analyses. The supervised classification and regression tree was applied to identify optimal cut-off points. Its performance was evaluated by the value of the receiver operating characteristics curve, sensitivity and specificity.Results: Findings revealed that the optimal cut-off point for the attentional subscale was 7, and for the retrieval subscale was 13. Both cut-off points presented acceptable discrimination performance. An independent t-test indicated that both cut-off points were associated with significant differences in scores on neuropsychological measures of retrieval (episodic memory and verbal fluency) as well as neuropsychological measures of higher-level attention (working memory).Conclusion: The identified cut-off points may be helpful for women to track or quantify their subjective experiences of brain fog or cognitive symptoms during the menopause transition.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"51-60"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Perimenopausal combined hormonal contraception: focus on sexual function. 围绝经期联合荷尔蒙避孕：关注性功能。

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-01 Epub Date: 2024-11-13 DOI: 10.1080/13697137.2024.2423872

Tevfik Yoldemir

{"title":"Perimenopausal combined hormonal contraception: focus on sexual function.","authors":"Tevfik Yoldemir","doi":"10.1080/13697137.2024.2423872","DOIUrl":"10.1080/13697137.2024.2423872","url":null,"abstract":"Age alone should not be an absolute contraindication for any contraceptive methods. However, medical eligibility criteria for combined hormonal contraception (CHC) use must be taken into consideration when choosing an appropriate contraceptive method. Women should be counseled on the benefits and risks of CHC while in their 40s. If there are no contraindications, women may use CHC for contraception up until the age of 50 years. Loss of libido is a common symptom during the late 40s. While women associate this with hormone levels, libido is multifactorial and is influenced by family and work stress, tiredness, self-image, medications and the physical changes in their partner. During this stage, women might experience urogenital issues such as vaginal dryness, dyspareunia and bladder problems, which can further affect the woman's sexual function. Before attributing the cause of sexual dysfunction to CHC use, a complete gynecologic examination and a full biopsychosocial assessment of the woman and her partner should be conducted to define other potential causes. When CHC-related female sexual dysfunction is suspected, using an oral CHC with a higher estrogen dose, a vaginal contraceptive ring or a transdermal contraceptive patch, or switching to a progesterone-only pill or non-hormonal method, might be suggested.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"15-20"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0