IF 3.9 4区医学

Climacteric Pub Date : 2026-08-24 DOI: 10.1080/13697137.2026.2713394

Vanessa Alves Lobato, Tatiana Palotta Minari, Luciana Pellegrini Pisani

{"title":"Perimenopause and metabolic vulnerability: hormones, body composition and lifestyle changes.","authors":"Vanessa Alves Lobato, Tatiana Palotta Minari, Luciana Pellegrini Pisani","doi":"10.1080/13697137.2026.2713394","DOIUrl":"https://doi.org/10.1080/13697137.2026.2713394","url":null,"abstract":"Perimenopause is a transitional phase characterized by substantial hormonal fluctuations, particularly declining estradiol levels, accompanied by age-related metabolic changes. Increasing evidence suggests that this period constitutes a critical window of metabolic vulnerability, marked by adverse alterations in body composition, energy metabolism and cardiometabolic health. Notably, these changes may develop even without significant increases in body weight, potentially delaying their recognition in clinical settings. A narrative review was conducted using the PubMed/MEDLINE, Scopus, Web of Science and SciELO databases. Studies involving perimenopausal women, plus relevant animal models, were included. Search terms covered estrogen deficiency, body composition, metabolism, insulin resistance, inflammation, physical activity and nutrition. Fifty-six studies published between 2000 and 2026 were analyzed. Evidence shows that perimenopause is characterized by increased visceral fat, loss of lean mass, reduced fat oxidation and impaired metabolic flexibility, even without major weight changes. Declining estrogen drives adipose redistribution, muscle dysfunction, hepatic insulin resistance and chronic low-grade inflammation. These changes heighten risk for metabolic syndrome, type 2 diabetes and cardiovascular events. Lifestyle interventions, particularly resistance training and Mediterranean diet adherence, demonstrate strong potential to preserve muscle, improve insulin sensitivity and reduce inflammation. In conclusion, perimenopause should be recognized as a pivotal stage for early detection and prevention of metabolic dysfunction. Lifestyle-based interventions during this phase may reduce long-term cardiometabolic risk and improve women's health.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-16"},"PeriodicalIF":3.9,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808230","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaginal and urinary microbiomes in postmenopausal women and breast cancer survivors and their associations with genitourinary syndrome of menopause: a scoping review. 绝经后妇女和乳腺癌幸存者的阴道和尿液微生物组及其与绝经期泌尿生殖系统综合征的关系：范围综述

IF 3.9 4区医学

Climacteric Pub Date : 2026-08-24 DOI: 10.1080/13697137.2026.2713393

Mathilde Elisabeth Steen Valland, Sine Jacobsen, Caspar Bundgaard-Nielsen, Pinar Bor

{"title":"Vaginal and urinary microbiomes in postmenopausal women and breast cancer survivors and their associations with genitourinary syndrome of menopause: a scoping review.","authors":"Mathilde Elisabeth Steen Valland, Sine Jacobsen, Caspar Bundgaard-Nielsen, Pinar Bor","doi":"10.1080/13697137.2026.2713393","DOIUrl":"https://doi.org/10.1080/13697137.2026.2713393","url":null,"abstract":"Genitourinary syndrome of menopause (GSM) is common among postmenopausal women and breast cancer survivors, particularly those receiving antiestrogen therapy. However, the role of the urinary and vaginal microbiomes in GSM remains underexplored. This study aimed to evaluate urinary and vaginal microbiome differences and their association with GSM in postmenopausal women and breast cancer survivors. A scoping review (PubMed, Embase; May 2025) identified 877 studies addressing the vaginal or urinary microbiome in postmenopausal women and 242 studies in breast cancer survivors. After screening and eligibility assessment, 18 studies involving postmenopausal women and three studies involving breast cancer survivors were included. Across 21 included studies (n = 30-1320 participants), Lactobacillus depletion and anaerobic overgrowth (e.g. Gardnerella, Prevotella, Sneathia) were associated with GSM. Postmenopausal women with low-Lactobacillus community state types (CSTs) had up to 25.9-fold higher odds of GSM. In breast cancer survivors, Lactobacillus was nearly absent (5% of samples), with increased Gardnerella and Sneathia in symptomatic women. Associations between Lactobacillus relative abundance and symptom severity were inconsistent. In conclusion, GSM appears to be associated with microbial dysbiosis characterized by anaerobic overgrowth, rather than Lactobacillus depletion alone. Estrogen suppression in breast cancer survivors may exacerbate dysbiosis and symptoms, highlighting the need for microbiome-targeted treatments.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-9"},"PeriodicalIF":3.9,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808275","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Women's and health professionals' needs and preferences informing the updated IMS recommendations. 妇女和卫生专业人员的需求和偏好，为最新的IMS建议提供信息。

IF 3.9 4区医学

Climacteric Pub Date : 2026-08-24 DOI: 10.1080/13697137.2026.2715963

A J Vincent, L Yeganeh, A Fenton, H Hamoda, N Panay

{"title":"Women's and health professionals' needs and preferences informing the updated IMS recommendations.","authors":"A J Vincent, L Yeganeh, A Fenton, H Hamoda, N Panay","doi":"10.1080/13697137.2026.2715963","DOIUrl":"https://doi.org/10.1080/13697137.2026.2715963","url":null,"abstract":"Objective: This study aimed to identify and compare the priorities for content and accompanying resources of midlife women (MW) and health professionals (HPs) to inform the updated International Menopause Society (IMS) recommendations.Method: Two online multi-language surveys with a range of response options were disseminated internationally to MW aged 45-65 years and HPs, respectively. Data analysis used descriptive statistics, chi-square and Leximancer thematic analysis of free text responses.Results: Approximately 50% of respondents were European and 50% from the rest of the world. Among MW (n = 756), 44.8% were postmenopausal, 85% reported menopausal symptoms and 82% had consulted a HP regarding menopause. Among HPs (n = 500), most were gynecologists (49.2%), and 286/499 were aware of and 246/279 used the 2016 IMS recommendations. Although >70% respondents perceived that most 2016 topics be retained, similarities and differences between the priorities of HPs and MW were identified. HPs prioritized premature ovarian insufficiency, breast cancer and non-pharmacological/lifestyle interventions; MW emphasized midlife body changes, skin, heart/brain health, quality of life, novel therapies and media/pharma influences. There were significant differences in the accompanying resources preferred by MW and HPs.Conclusion: This study highlights the different priorities and resource needs of MW and HPs. These findings informed the updated IMS recommendations to better address stakeholder needs.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-6"},"PeriodicalIF":3.9,"publicationDate":"2026-08-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148808284","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Literature review of estradiol/dydrogesterone in perimenopausal and postmenopausal women. 雌二醇/地孕酮在围绝经期和绝经后妇女中的文献综述。

IF 3.9 4区医学

Climacteric Pub Date : 2026-08-18 DOI: 10.1080/13697137.2026.2709302

Rossella E Nappi, Malgorzata Binkowska, Herman Depypere, Claudia Mehenditu, Petra Stute, Renata Zablotna-Pociupany, John C Stevenson

{"title":"Literature review of estradiol/dydrogesterone in perimenopausal and postmenopausal women.","authors":"Rossella E Nappi, Malgorzata Binkowska, Herman Depypere, Claudia Mehenditu, Petra Stute, Renata Zablotna-Pociupany, John C Stevenson","doi":"10.1080/13697137.2026.2709302","DOIUrl":"https://doi.org/10.1080/13697137.2026.2709302","url":null,"abstract":"Menopausal hormone therapy (MHT) with 17β-estradiol/dydrogesterone (E/D) or Femoston® at a range of doses has been shown to provide effective relief from climacteric symptoms and prevention of osteoporosis in postmenopausal women. However, less is known about personalizing MHT for women who require lower doses, or those with obesity or overweight. A literature search was conducted using PubMed to evaluate the safety and efficacy of E/D in perimenopausal and postmenopausal women, with a focus on women with high body mass index (BMI). The results confirmed that ultra-low and standard doses of E/D provide effective relief from symptoms of estrogen depletion, high rates of amenorrhea and fracture risk reduction, without any new safety concerns. In women with high BMI, E/D was shown to provide effective symptom relief, with no significant differences in adverse event frequency according to BMI subgroups. Safety data suggested that dydrogesterone may confer advantages in terms of venous thromboembolism and breast cancer risk as compared with other progestogens. The findings of this literature review shed light on options for optimizing MHT treatment and doses for perimenopausal and postmenopausal women. Further research is warranted to confirm findings in women with high BMI.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-11"},"PeriodicalIF":3.9,"publicationDate":"2026-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148788914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cross-sectional survey of perimenopausal women for menopause symptoms and attitudes in Singapore. 新加坡围绝经期妇女更年期症状和态度的横断面调查。

IF 3.9 4区医学

Climacteric Pub Date : 2026-08-11 DOI: 10.1080/13697137.2026.2707847

Dypti Lulla, Seng Bin Ang, Shirley L L Kwok, Jean-Jasmin M L Lee, Rukshini Puvanendran

{"title":"Cross-sectional survey of perimenopausal women for menopause symptoms and attitudes in Singapore.","authors":"Dypti Lulla, Seng Bin Ang, Shirley L L Kwok, Jean-Jasmin M L Lee, Rukshini Puvanendran","doi":"10.1080/13697137.2026.2707847","DOIUrl":"https://doi.org/10.1080/13697137.2026.2707847","url":null,"abstract":"Objective: Menopause symptoms and experiences vary considerably between women and can be influenced by multiple biopsychosocial and cultural factors, age and ethnicity. This study investigated the symptoms and attitudes of perimenopausal women in Singapore.Method: Women aged 40-60 years attending women's health talks and forums in Singapore completed an anonymized, voluntary online questionnaire in English. The study collected demographic information, and assessed menopause status and attitudes toward menopause and hormone therapy. Participants reporting menopause symptoms completed the Menopause Rating Scale (MRS) questionnaire.Results: A total of 147 perimenopausal women reported at least one moderate to very severe symptom of menopause. The most common menopause symptoms reported were joint and muscular discomfort (44.2%), followed by sleep problems (43.5%) and physical and mental exhaustion (39.5%). Common terms for attitudes toward menopause included natural (51.3%), old age (45.0%), and threatening, dreading, causing symptoms and health problems (40.0%).Conclusion: This study sheds light on common symptoms of perimenopausal women and their attitudes toward menopause and hormone therapy.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-7"},"PeriodicalIF":3.9,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705554","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Reproductive, lifestyle, socioeconomic and anthropometric correlates of early menopause. 生殖、生活方式、社会经济和人体测量学与早期绝经相关。

IF 3.9 4区医学

Climacteric Pub Date : 2026-08-11 DOI: 10.1080/13697137.2026.2707856

Keiko Yamanouchi, Tsuyoshi Ohta, Tsuneo Konta, Risako Yamaguchi, Midori Saito, Fumihiro Nakamura, Shouta Horikawa, Kazuyoshi Sakai, Norikazu Watanabe, Manabu Seino, Satoru Nagase

{"title":"Reproductive, lifestyle, socioeconomic and anthropometric correlates of early menopause.","authors":"Keiko Yamanouchi, Tsuyoshi Ohta, Tsuneo Konta, Risako Yamaguchi, Midori Saito, Fumihiro Nakamura, Shouta Horikawa, Kazuyoshi Sakai, Norikazu Watanabe, Manabu Seino, Satoru Nagase","doi":"10.1080/13697137.2026.2707856","DOIUrl":"https://doi.org/10.1080/13697137.2026.2707856","url":null,"abstract":"Objective: This study aimed to identify lifestyle, reproductive and socioeconomic correlates of early menopause (age <45 years) in a cross-sectional analysis of a population-based cohort of Japanese women.Method: The study analyzed data from 6313 naturally menopausal women in the Yamagata Cohort Study (2009-2015). Women were classified as having early menopause (age <45 years; n = 239) or menopause at age 45-54 years (n = 6074). Data included age at menarche, menstrual pattern at age 20 years, educational attainment, marital status, parity, breastfeeding, smoking and body mass index (BMI). Multivariable logistic regression estimated odds ratios (ORs) with 95% confidence intervals (CIs).Results: Lower educational attainment (OR 1.84, 95% CI 1.32-2.57) and never-married status (OR 2.52, 95% CI 1.24-5.11) were associated with early menopause. Low BMI was associated with early menopause in univariate analysis but not after multivariable adjustment. An interaction was observed between menstrual pattern at age 20 years and BMI: among women with menstrual irregularity, obesity (BMI ≥25 kg/m2) was associated with higher odds of early menopause (OR 3.49, 95% CI 1.91-6.37).Conclusion: In this cross-sectional analysis of a population-based cohort of Japanese women, lower educational attainment and never-married status were associated with early menopause. Women with menstrual irregularity and obesity may be at increased risk of early menopause.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-6"},"PeriodicalIF":3.9,"publicationDate":"2026-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148705656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Menarche, menopause, reproductive life span and menopause-specific quality of life: a cohort study. 月经初潮、更年期、生殖寿命和更年期特异性生活质量：一项队列研究。

IF 3.9 4区医学

Climacteric Pub Date : 2026-08-07 DOI: 10.1080/13697137.2026.2702817

Zhuolin Xie, Ruiyi Tang, Feiling Huang, Penghui Feng, Yubo Fan, Xuanjin Yang, Jingbo Huang, Xiaonan Ma, Shiman Yuan, Rong Chen

{"title":"Menarche, menopause, reproductive life span and menopause-specific quality of life: a cohort study.","authors":"Zhuolin Xie, Ruiyi Tang, Feiling Huang, Penghui Feng, Yubo Fan, Xuanjin Yang, Jingbo Huang, Xiaonan Ma, Shiman Yuan, Rong Chen","doi":"10.1080/13697137.2026.2702817","DOIUrl":"https://doi.org/10.1080/13697137.2026.2702817","url":null,"abstract":"Objective: This study aimed to investigate the associations of menarche age, menopause age and reproductive life span with menopausal symptoms in Chinese women.Methods: The prospective, longitudinal study included 557 midlife Chinese women. Menopausal symptoms were evaluated through the Menopause-Specific Quality of Life (MENQOL) questionnaire, covering vasomotor symptoms (VMS), psychosocial, physical and sexual domains. Generalized estimating equation models were used to estimate the crude and adjusted mean differences (β) and 95% confidence intervals (CI).Results: Mean menarche and menopause ages were 13.92 ± 1.62 and 50.56 ± 3.20 years, with a mean reproductive life span of 36.64 ± 3.56 years. Age at menarche was not associated with MENQOL domain scores. Earlier menopause and shorter reproductive life span were associated with higher adjusted sexual-domain scores, with significant differences for menopause before age 45 years (β = 0.83, 95% CI: 0.21, 1.44) and reproductive life span <30 years (β = 0.98, 95% CI: 0.21, 1.74). These sexual-domain associations were attenuated after adjustment for time since menopause, whereas associations with higher VMS scores became apparent in postmenopausal analyses. No significant associations were observed for psychosocial or physical-domain scores.Conclusion: Earlier menopause and shorter reproductive life span were associated with MENQOL-assessed sexual-domain discomfort, partly explained by time since menopause. Additional postmenopausal analyses also linked these factors to greater VMS burden.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-10"},"PeriodicalIF":3.9,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Photobiomodulation and pelvic floor training for genitourinary syndrome: RCT results. 泌尿生殖系统综合征的光生物调节和盆底训练：RCT结果。

IF 3.9 4区医学

Climacteric Pub Date : 2026-08-07 DOI: 10.1080/13697137.2026.2702818

Lívia Oliveira Bezerra, Edson Silva-Filho, Maria Leticia Araújo Silva de Carvalho, Patrícia Froes Meyer, Palloma Rodrigues de Andrade, Maria Thereza Albuquerque Barbosa Cabral Micussi

{"title":"Photobiomodulation and pelvic floor training for genitourinary syndrome: RCT results.","authors":"Lívia Oliveira Bezerra, Edson Silva-Filho, Maria Leticia Araújo Silva de Carvalho, Patrícia Froes Meyer, Palloma Rodrigues de Andrade, Maria Thereza Albuquerque Barbosa Cabral Micussi","doi":"10.1080/13697137.2026.2702818","DOIUrl":"https://doi.org/10.1080/13697137.2026.2702818","url":null,"abstract":"Objective: This study aimed to evaluate the effects of photobiomodulation (PBM) alone and in combination with pelvic floor muscle training (PFMT) on pelvic floor muscle (PFM) function, sexual and urinary function, and quality of life in women with genitourinary syndrome of menopause.Method: The three-arm clinical trial included women aged 45-65 years who had experienced natural menopause for at least 1 year. Participants were randomized into three groups: PFMT + active PBM, PFMT + sham PBM and isolated PFMT. Interventions lasted 8 weeks, with participants attending two 50-min sessions per week. Outcomes were assessed before and after the 16th session.Results: Although manometry showed no significant differences between groups, the intervention group demonstrated greater numerical improvement. The Female Sexual Function Index (FSFI) total score differed significantly between the PFMT + active PBM and PFMT + sham PBM groups (mean difference = 4.55; 95% confidence interval: 0.57, 8.52; d = 1.05). Significant between-group differences were also observed in the orgasm subdomain in favor of the PFMT + active PBM group compared to the PFMT + sham PBM group. The International Consultation on Incontinence Questionnaire - short form (ICIQ-SF) indicated a clinically significant improvement of 3.06 points in the PFMT + active PBM group compared to the PFMT + sham PBM group following the intervention.Conclusion: Active PBM combined with PFMT showed greater but non-significant improvements in PFM pressure, urinary function and quality of life, while significantly improving only sexual function.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-9"},"PeriodicalIF":3.9,"publicationDate":"2026-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The enigma of associations between reproductive health and development of osteoarthritis in midlife: a life-course approach. 生殖健康与中年骨关节炎发展之间的关联之谜：一种生命历程方法。

IF 3.9 4区医学

Climacteric Pub Date : 2026-08-05 DOI: 10.1080/13697137.2026.2699763

Fiona Kirkham-Wilson, Ikrah Shah, Roshan Rambukwella, Elaine Dennison

{"title":"The enigma of associations between reproductive health and development of osteoarthritis in midlife: a life-course approach.","authors":"Fiona Kirkham-Wilson, Ikrah Shah, Roshan Rambukwella, Elaine Dennison","doi":"10.1080/13697137.2026.2699763","DOIUrl":"https://doi.org/10.1080/13697137.2026.2699763","url":null,"abstract":"Osteoarthritis (OA) is the most common form of arthritis. OA becomes more prevalent in women around the age of menopause, and it has been suggested that the decrease in estrogen at menopause may be important in the pathophysiology of OA development. The association between estrogen exposure and OA is complex; a recent meta-analysis suggested that menopause hormone therapy use may be associated with an increased risk of joint replacement, bringing this research area back into focus. This narrative review used a systematic process, adopting a life-course approach to consider relationships between reproductive factors and OA, identifying 15 papers published over a 26-year period. Increased parity, use of the oral contraceptive pill, abortion, breastfeeding and inter-menstrual years were all considered but findings varied widely between studies. We note that progesterone is rarely considered, despite animal work suggesting its importance. These data highlight the need for further research with careful measurements of confounding variables, and consideration of the role for progesterone in OA etiology.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-10"},"PeriodicalIF":3.9,"publicationDate":"2026-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148672880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Menopausal hormone use after hysterectomy in endometriosis: a Finnish register-based study. 子宫内膜异位症子宫切除术后绝经期激素的使用：芬兰一项基于登记的研究。

IF 3.9 4区医学

Climacteric Pub Date : 2026-08-01 Epub Date: 2026-04-01 DOI: 10.1080/13697137.2026.2639979

Milla Sipilä, Liisu Saavalainen, Juuso Saavalainen, Oskari Heikinheimo

{"title":"Menopausal hormone use after hysterectomy in endometriosis: a Finnish register-based study.","authors":"Milla Sipilä, Liisu Saavalainen, Juuso Saavalainen, Oskari Heikinheimo","doi":"10.1080/13697137.2026.2639979","DOIUrl":"10.1080/13697137.2026.2639979","url":null,"abstract":"Objective: This study aimed to examine the frequency and type of menopausal hormone therapy (MHT) use after hysterectomy among women with surgically diagnosed endometriosis.Method: A retrospective register-based cohort study identified women with a first surgical diagnosis of endometriosis and a reference cohort using Finnish national registries. This study included women aged ≤45 years with hysterectomy and bilateral oophorectomy, and women >45 years with hysterectomy performed between 1996 and 2018. Women with a history of thrombosis, breast cancer or gynecological cancer were excluded. MHT use was identified from national reimbursement registry until the end of 2019.Results: Altogether 11,365 women were included: 1748 women aged ≤45 years and 9617 aged >45 years. Among women with endometriosis, 94.3% (aged ≤45 years) and 73.1% (aged >45 years) used MHT postoperatively, compared with 81.8% and 51.5% in the reference cohort (p < 0.001). Estrogen-only therapy was the most commonly used MHT, but the use of combined estrogen-progestin therapy increased significantly (p < 0.001).Conclusion: MHT use was very common in women with endometriosis. The shift toward combined therapy reflects evolving international guidance. The high rate of MHT use underscores the need for studies assessing its long-term outcomes in women with endometriosis.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"571-577"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147589667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

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