Climacteric最新文献

{"title":"Corneal thickness, contrast sensitivity and binocular vision in menopausal and non-menopausal women.","authors":"Hemn Baghban Jaldian, Ali Mirzajani, Rasoul Amini Vishteh, Jamileh Abolghasemi, Parva Pourbagherkhah","doi":"10.1080/13697137.2024.2438733","DOIUrl":"https://doi.org/10.1080/13697137.2024.2438733","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the effects of menopause on ocular health and visual function.</p><p><strong>Method: </strong>Sixty-two women (31 premenopausal and 31 postmenopausal) who visited Rasht Health Center were selected and matched based on their ages and compared in terms of their hormonal status, central corneal thickness (CCT), contrast sensitivity (CS), binocular vision variables and refractive error.</p><p><strong>Results: </strong>CCT and corneal curvature were significantly thinner in postmenopausal women. However, menopause had no significant impact on CS, binocular vision or refractive error.</p><p><strong>Conclusion: </strong>Age-related hormonal abnormalities play a significant role in corneal thinning, highlighting the intricate relationship between systemic hormonal changes and ocular health. In contrast, binocular vision functions remain unaffected by menopause.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-5"},"PeriodicalIF":2.9,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of sexual counseling based on the PLISSIT model on improving the sexual function of postmenopausal women: a randomized controlled trial.","authors":"Molouk Jaafarpour, Nasrin Rashan, Mona Bahmani, Ashraf Direkvand-Moghadam","doi":"10.1080/13697137.2024.2429426","DOIUrl":"https://doi.org/10.1080/13697137.2024.2429426","url":null,"abstract":"<p><strong>Objective: </strong>Menopause can impact women's physical and mental well-being, including sexual function. The present study aims to evaluate the effect of sexual counseling based on the PLISSIT model on improving the sexual function of postmenopausal women.</p><p><strong>Methods: </strong>The randomized trial focused on postmenopausal married women who did not have any pre-existing health conditions. The intervention group were provided with personalized sexual counseling grounded in the PLISSIT model, whereas the control group were given educational pamphlets. Participants filled out the Female Sexual Function Index (FSFI) questionnaire and were categorized into two groups through randomized blocking, utilizing blocks of four and six. The main outcome measure was the average sexual function score assessed at the start of the study, as well as at 4 and 8 weeks following the intervention.</p><p><strong>Results: </strong>A total of 60 eligible participants were included in the study. The mean ± standard deviation participant age was 58.7 ± 3.5 years. At week 4 following the intervention, statistically significant differences were observed between the study groups in the mean scores of sexual desire (<i>p</i> = 0.023), arousal (<i>p</i> = 0.002), orgasm (<i>p</i> = 0.0001), lubrication (<i>p</i> = 0.001) and satisfaction (<i>p</i> = 0.004). At week 8 following the intervention, significant differences were noted in the mean scores for sexual arousal (<i>p</i> = 0.001), orgasm (<i>p</i> = 0.000), lubrication (<i>p</i> = 0.031) and satisfaction (<i>p</i> = 0.004) between the study groups.</p><p><strong>Conclusion: </strong>The sexual counseling based on the PLISSIT model can significantly improve sexual function in postmenopausal women, making it a valuable intervention for healthcare providers to consider in their practice.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-7"},"PeriodicalIF":2.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of a therapeutic lifestyle modification intervention on health-related quality of life and sexual functioning and cardiometabolic health in perimenopausal Chinese women: a randomized controlled trial.","authors":"Yuru Wang, Xiaoling Miao, Pramon Viwattanakulvanid","doi":"10.1080/13697137.2024.2435879","DOIUrl":"https://doi.org/10.1080/13697137.2024.2435879","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effects of a therapeutic lifestyle modification (TLM) intervention on health-related quality of life, sexual functioning and cardiometabolic health in perimenopausal Chinese women.</p><p><strong>Method: </strong>The study was a randomized controlled trial (registration number: ChiCTR2300070648). Ninety-four perimenopausal women aged between 40 and 55 years were randomly assigned in a 1:1 ratio to receive the TLM intervention or usual care for 12 weeks. Menopause-specific Quality of Life (MENQOL), Female Sexual Function Index (FSFI), pelvic floor muscle strength (PFMS) and composite cardiometabolic indicators were evaluated at baseline and post intervention.</p><p><strong>Results: </strong>After 12 weeks, linear mixed-effects models showed that the TLM intervention led to a statistically significant improvement in MENQOL (-0.60, 95% confidence interval [CI] - 0.80 to -0.41), FSFI (3.82, 95% CI 2.03 to 5.61), resting heart rate (-5.44, 95% CI -10.40 to -0.48), waist circumference(-3.14, 95% CI -4.15 to -2.13) and body fat percentage (-4.25, 95% CI -6.92 to -1.58) compared to the control group. There were also statistically significant differences between the intervention (TLM) group and the control group in the proportions of PFMS (<i>p</i> = 0.006).</p><p><strong>Conclusion: </strong>The TLM intervention effectively improved menopause-specific quality of life in midlife women, supported by enhancements in female sexual functioning and cardiometabolic health status.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-12"},"PeriodicalIF":2.9,"publicationDate":"2024-12-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Concentration and genetic regulation of sex hormone binding globulin and fracture risk in older women.","authors":"Yuanyuan Wang, Chenglong Yu, Rakibul M Islam, Sultana Monira Hussain, Anna L Barker, Paul Lacaze, John J McNeil, Susan R Davis","doi":"10.1080/13697137.2024.2431036","DOIUrl":"10.1080/13697137.2024.2431036","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the association between concentrations of sex hormone binding globulin (SHBG) and fracture risk in community-dwelling older women and explore whether this was explained by the genetic regulation of SHBG.</p><p><strong>Methods: </strong>This prospective cohort study examined 4871 women aged ≥70 years who were not taking medications influencing SHBG concentrations. A genome-wide association study was undertaken to identify single nucleotide polymorphisms (SNPs) associated with SHBG concentrations. Incident fracture was confirmed by medical imaging and adjudicated by expert review committee.</p><p><strong>Results: </strong>The median age of participants was 74.0 years. Over 3.9 (standard deviation 1.4) years of follow-up, 484 participants had an incident fracture. There was a linear trend for a positive association between SHBG concentrations and fracture risk (<i>p</i> = 0.001), with the highest SHBG quartile associated with a significantly greater fracture risk compared with the lowest quartile (hazard ratio 1.54, 95% confidence interval 1.16-2.04, <i>p</i> = 0.003), adjusting for age, body mass index, alcohol consumption, smoking, diabetes, impaired renal function, treatment allocation, medications affecting bone and high-density lipoprotein cholesterol. Two independent SNPs were associated with SHBG concentrations, rs10822163 and rs727428, but neither was associated with fracture risk.</p><p><strong>Conclusion: </strong>SHBG concentrations were positively associated with a greater fracture risk in community-dwelling women aged ≥70 years, which was not explained by genetic variants associated with SHBG regulation.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-7"},"PeriodicalIF":2.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating the triglyceride-glucose index in postmenopausal osteoporosis.","authors":"Busra Korpe, Caner Kose, Sumeyye Mermi, Samet Kutluay Ergorun, Huseyin Levent Keskin","doi":"10.1080/13697137.2024.2429430","DOIUrl":"https://doi.org/10.1080/13697137.2024.2429430","url":null,"abstract":"<p><strong>Objective: </strong>This retrospective study aims to assess the association of the triglyceride-glucose index (TyG index) with postmenopausal osteoporosis and investigate longitudinal changes in TyG index levels in relation to osteoporosis risk.</p><p><strong>Methods: </strong>Out of 704 women, after excluding those with osteopenia, a total of 517 patients who met the inclusion criteria were included. Participants were categorized based on <i>T</i>-scores derived from lumbar spine dual-energy X-ray absorptiometry scans. Demographic data, biochemical parameters and TyG index levels were analyzed. Logistic regression, correlation analysis and receiver operating characteristic (ROC) curve analysis were employed for statistical evaluation.</p><p><strong>Results: </strong>The osteoporosis group (<i>n</i> = 254) exhibited significantly higher TyG index and triglyceride levels compared to controls (<i>n</i> = 263). Longitudinal analysis revealed significant increases in TyG index levels among women developing osteoporosis over time. ROC analysis demonstrated the TyG index's accuracy for osteoporosis (first TyG area under the curve [AUC]: 0.767, second TyG AUC: 0.818, <i>p</i> < 0.001). Regression analyses identified the TyG index as a significant factor associated with osteoporosis (odds ratio: 39.468, 95% confidence interval: 12.884-120.903, <i>p</i> < 0.001).</p><p><strong>Conclusions: </strong>The TyG index emerges as a valuable indicator for postmenopausal osteoporosis. These results emphasize the need for integrating metabolic health indicators into osteoporosis management strategies, warranting further research into targeted interventions.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-6"},"PeriodicalIF":2.9,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of serum uric acid with handgrip strength and dynapenia in postmenopausal women.","authors":"Pascual García-Alfaro, Faustino R Pérez-López, Ignacio Rodríguez","doi":"10.1080/13697137.2024.2429423","DOIUrl":"https://doi.org/10.1080/13697137.2024.2429423","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the association of serum uric acid levels with handgrip strength (HGS) and dynapenia in postmenopausal women.</p><p><strong>Methods: </strong>A cross-sectional study among 422 participants collected data on age, age at menopause, adiposity, alcohol consumption, body mass index, current smoking status, HGS (measured using a digital dynamometer) and physical activity. Serum levels of creatinine, glucose, glycated hemoglobin, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, thyroid-stimulating hormone and uric acid were evaluated. Women were categorized into quartiles. A directed acyclic graph was designed to identify confounding variables. Multivariable regression analysis was used to assess associations between uric acid with HGS or dynapenia.</p><p><strong>Results: </strong>Women with hyperuricemia presented significant association with lower HGS (<i>p</i> = 0.00028). After adjusting for potential confounders, the multivariable linear regression to analyze the association between uric acid and HGS showed an inverted U-shaped curve, with quartile 1 (β = -0.54; 95% confidence interval [CI]: -1.50, 0.40), quartile 3 (β = -0.21; 95% CI: -1.20, 0.74) and quartile 4 (β = -1.3; 95% CI: -2.3, -0.37) compared with quartile 2. Serum uric acid levels were significantly associated with HGS (<i>p</i> = 0.036).</p><p><strong>Conclusions: </strong>The association between uric acid quartiles with HGS or dynapenia displayed an inverted U-shaped curve. These findings suggest that specific serum uric acid levels within the normal range are associated with better HGS.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-7"},"PeriodicalIF":2.9,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evidence-based guideline: premature ovarian insufficiency^†^‡.","authors":"Nick Panay, Richard A Anderson, Amy Bennie, Marcelle Cedars, Melanie Davies, Carolyn Ee, Claus H Gravholt, Sophia Kalantaridou, Amanda Kallen, Kimberly Q Kim, Micheline Misrahi, Aya Mousa, Rossella E Nappi, Walter A Rocca, Xiangyan Ruan, Helena Teede, Nathalie Vermeulen, Elinor Vogt, Amanda J Vincent","doi":"10.1080/13697137.2024.2423213","DOIUrl":"10.1080/13697137.2024.2423213","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Study question: &lt;/strong&gt;How should premature/primary ovarian insufficiency (POI) be diagnosed and managed, based on the best available evidence from published literature?&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Summary answer: &lt;/strong&gt;The current guideline provides 145 recommendations on symptoms, diagnosis, causation, sequelae and treatment of POI.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;What is known already: &lt;/strong&gt;POI presents a significant challenge to women's health, with far-reaching implications, both physically and emotionally. The potential implications include adverse effects on quality of life, on fertility and on bone, cardiovascular and cognitive health. Although hormone therapy (HT) can mitigate some of these effects, many questions still remain regarding the optimal management of POI.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Study design, size, duration: &lt;/strong&gt;The guideline was developed according to the structured methodology for development of European Society of Human Reproduction and Embryology (ESHRE) guidelines. Key questions were determined by a group of experts and informed by a scoping survey of women and healthcare professionals. Literature searches and assessment were then performed. Papers published up to 30 January 2024 and written in English were included in the guideline. An integrity review was conducted for the randomized controlled trials on POI included in the guideline.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Participants/materials, setting, methods: &lt;/strong&gt;Based on the collected evidence, recommendations were formulated and discussed within the guideline development group until consensus was reached. Women with lived experience of POI informed the recommendations in general, and particularly those on provision of care. A stakeholder review was organized after finalization of the draft. The final version was approved by the guideline development group and the ESHRE Executive Committee.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Main results and the role of chance: &lt;/strong&gt;New data indicate a higher prevalence of POI, 3.5%, than was previously thought. This guideline aims to help healthcare professionals apply best practice care for women with POI. The recent update of the POI guideline covers 40 clinical questions on diagnosis of the condition, the different sequelae, including bone, cardiovascular, neurological and sexual function, fertility and general well-being, and treatment options, including HT. The list of clinical questions was expanded from the previous iteration of the guideline (2015) based on the scoping survey and appreciation of emerging knowledge of POI. Questions were added on the role of anti-Müllerian hormone (AMH) in the diagnosis of POI, fertility preservation, muscle health and specific considerations for HT in iatrogenic POI. Additionally, the topic on complementary treatments was extended with specific focus on non-hormonal treatments and lifestyle management options. Significant changes from the previous 2015 guideline include the recommendations that only one elevated follicle stimulating hormone","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"510-520"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142794310","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physician-patient alignment on menopause-associated symptom burden: real-world evidence from the USA and Europe.","authors":"Sheryl Kingsberg, Rossella E Nappi, Megan Scott, Nils Schoof, Carsten Moeller, Lauren Lee, Cecile Janssenswillen, Cecilia Caetano, Victoria Banks","doi":"10.1080/13697137.2024.2401366","DOIUrl":"10.1080/13697137.2024.2401366","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate physician-patient alignment on menopausal symptom burden and impact for women experiencing natural vasomotor symptoms (nVMS) or VMS induced by endocrine therapy for breast cancer (iVMS).</p><p><strong>Methods: </strong>For this real-world, cross-sectional survey, physicians from the USA and five European countries provided data for consulting patients experiencing nVMS/iVMS; patients optionally self-reported their experiences. Alignment between physician and patient responses was assessed using weighted Cohen's <i>κ</i> analysis.</p><p><strong>Results: </strong>Physicians and patients completed 1029 pairs of surveys (846 nVMS; 183 iVMS). In 28.1% of cases for nVMS and 29.6% for iVMS, patients reported more severe vasomotor symptoms (VMS) than physicians; alignment of responses was slight (nVMS, <i>κ</i> = 0.1364, <i>p</i> ≤ 0.0001; iVMS, <i>κ</i> = 0.1014, <i>p</i> = 0.039). For the non-VMS symptoms surveyed, 18.5-34.9% of patients with nVMS and iVMS reported symptoms without a corresponding physician report; sleep disturbances, cognitive difficulties and mood changes were among the symptoms most under-reported by physicians. Alignment regarding the impact of nVMS and iVMS on sleep, mood and overall quality of life was moderate.</p><p><strong>Conclusions: </strong>Only slight to moderate physician-patient alignment was found across all areas surveyed. These findings suggest that physicians often underestimate the severity of VMS and the presence of other menopausal symptoms, highlighting a need to improve physician-patient communication.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"534-541"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142459425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Is it possible that menopause is associated with telomere length? Findings of an integrative review.","authors":"M M S Bem, C M S Paraizo-Horvath, P S Freitas, T R P Brito","doi":"10.1080/13697137.2024.2376193","DOIUrl":"10.1080/13697137.2024.2376193","url":null,"abstract":"<p><strong>Objective: </strong>Knowing the important repercussions of menopause for women's health and that female longevity can be better understood through studies based on aging biomarkers, studies on the relationship between menopause and telomere shortening may help to better understand this stage of life. This study aimed to analyze what research has been produced regarding the relationship between menopause and telomere length.</p><p><strong>Methods: </strong>This integrative literature review included searches in PubMed, CINAHL, LILACS, Web of Science and Scopus databases. Four studies were selected for the final sample.</p><p><strong>Results: </strong>The findings of these studies indicate that older age for menopause and longer reproductive life (difference between age at menopause and menarche) are associated with longer telomeres, that is, with longevity.</p><p><strong>Conclusion: </strong>The relationship between menopause and telomere length is uncertain. The small number of studies included in this review, and the fact that the results indicate that the relationship between menopause and telomere length may be dependent on the stage of the menopause and race/ethnicity, suggest that additional research focusing on these variables should be carried out.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"521-525"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632821","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Rapid and random-start endometrial preparation before outpatient hysteroscopic polypectomy in patients of perimenopausal age.","authors":"Andrea Etrusco, Antonio D'Amato, Vittorio Agrifoglio, Vito Chiantera, Giuseppe Russo, Tullio Golia D'Augè, Marco Monti, Gaetano Riemma, Antonio Simone Laganà, Andrea Giannini","doi":"10.1080/13697137.2024.2404574","DOIUrl":"10.1080/13697137.2024.2404574","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the efficacy of randomly started oral dienogest/ethinylestradiol (DNG/EE) for swift endometrial preparation prior to outpatient hysteroscopic polypectomy in perimenopausal women.</p><p><strong>Method: </strong>A multicenter, prospective, randomized controlled trial was conducted in university hospitals. Eighty perimenopausal women scheduled for outpatient hysteroscopic polypectomy between January 2023 and March 2024 were randomly assigned to either intervention (<i>n</i> = 40) or control (<i>n</i> = 40) groups. Exclusion criteria included concomitant endometrial pathologies, recent therapy and adnexal diseases. The intervention group received oral DNG/EE 2 mg/0.03 mg/day started on any day of the menstrual cycle for 14 days. The control group underwent polypectomy between menstrual cycle days 8 and 11 without pharmacological treatment.</p><p><strong>Results: </strong>Pre-procedure (<i>p</i> < 0.001) and post-procedure (<i>p</i> < 0.001) endometrial thickness were significantly reduced in the intervention group, along with a higher incidence of hypotrophic/atrophic endometrial patterns (<i>p</i> < 0.001). Surgical parameters also differed significantly between groups.</p><p><strong>Conclusion: </strong>DNG/EE treatment offers rapid, cost-effective endometrial preparation, enhancing surgical outcomes and patient satisfaction during outpatient polypectomy.</p><p><strong>Trial registration: </strong>ClinicalTrials.gov NCT06316206.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"561-567"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}