Climacteric最新文献_第2页

The effect of sexual counseling based on the PLISSIT model on improving the sexual function of postmenopausal women: a randomized controlled trial. 基于 PLISSIT 模型的性咨询对改善绝经后妇女性功能的影响：随机对照试验。

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-01 Epub Date: 2024-12-13 DOI: 10.1080/13697137.2024.2429426

Molouk Jaafarpour, Nasrin Rashan, Mona Bahmani, Ashraf Direkvand-Moghadam

{"title":"The effect of sexual counseling based on the PLISSIT model on improving the sexual function of postmenopausal women: a randomized controlled trial.","authors":"Molouk Jaafarpour, Nasrin Rashan, Mona Bahmani, Ashraf Direkvand-Moghadam","doi":"10.1080/13697137.2024.2429426","DOIUrl":"10.1080/13697137.2024.2429426","url":null,"abstract":"Objective: Menopause can impact women's physical and mental well-being, including sexual function. The present study aims to evaluate the effect of sexual counseling based on the PLISSIT model on improving the sexual function of postmenopausal women.Methods: The randomized trial focused on postmenopausal married women who did not have any pre-existing health conditions. The intervention group were provided with personalized sexual counseling grounded in the PLISSIT model, whereas the control group were given educational pamphlets. Participants filled out the Female Sexual Function Index (FSFI) questionnaire and were categorized into two groups through randomized blocking, utilizing blocks of four and six. The main outcome measure was the average sexual function score assessed at the start of the study, as well as at 4 and 8 weeks following the intervention.Results: A total of 60 eligible participants were included in the study. The mean ± standard deviation participant age was 58.7 ± 3.5 years. At week 4 following the intervention, statistically significant differences were observed between the study groups in the mean scores of sexual desire (p = 0.023), arousal (p = 0.002), orgasm (p = 0.0001), lubrication (p = 0.001) and satisfaction (p = 0.004). At week 8 following the intervention, significant differences were noted in the mean scores for sexual arousal (p = 0.001), orgasm (p = 0.000), lubrication (p = 0.031) and satisfaction (p = 0.004) between the study groups.Conclusion: The sexual counseling based on the PLISSIT model can significantly improve sexual function in postmenopausal women, making it a valuable intervention for healthcare providers to consider in their practice.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"74-80"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Expanding knowledge across medical specialties in menopause research and practice: why it is so important for women's health.

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-01 Epub Date: 2025-01-31 DOI: 10.1080/13697137.2024.2437292

Rossella E Nappi, Tim Hillard

引用次数: 0

Factors influencing seogeulpeum among middle-aged Korean women. 影响韩国中年女性 Seogeulpeum 的因素。

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-01 Epub Date: 2024-11-13 DOI: 10.1080/13697137.2024.2421793

Hyeja Gu, Eunyoung Hong

{"title":"Factors influencing seogeulpeum among middle-aged Korean women.","authors":"Hyeja Gu, Eunyoung Hong","doi":"10.1080/13697137.2024.2421793","DOIUrl":"10.1080/13697137.2024.2421793","url":null,"abstract":"Objective: This study aimed to examine factors associated with seogeulpeum (a feeling of loneliness and solitude) - including aging anxiety, menopausal symptoms, social support and self-efficacy - in middle-aged women to provide fundamental data for future research endeavors.Methods: One hundred and fifty-nine women aged 40-60 years were recruited from two cities in Gyeongnam Province and Busan City. Gu and Eun's Seogeulpeum Scale was employed to evaluate seogeulpeum, alongside questionnaires to assess menopause status and symptoms, self-efficacy, social support and aging anxiety. To determine factors influencing seogeulpeum, a multiple stepwise regression analysis was conducted.Results: The average seogeulpeum score was 2.4 ± 0.44, indicating a moderate level of seogeulpeum experienced by the participants. Seogeulpeum was positively correlated with aging anxiety and menopausal symptoms, and negatively with self-efficacy and social support, among which aging anxiety most significantly influenced seogeulpeum. Aging anxiety, menopausal symptoms and social support combined accounted for 60.9% of the variation observed in seogeulpeum.Conclusions: The findings indicate the importance of health interventions aimed at reducing aging anxiety and menopausal symptoms and enhancing social support for promoting well-being and facilitating a healthy menopausal transition among middle-aged women. Additionally, seogeulpeum can serve as a valuable process indicator during this stage of multiple transitions for women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"40-50"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyaluronic acid and erbium laser for the treatment of genitourinary syndrome of menopause. 透明质酸和铒激光治疗更年期泌尿生殖系统综合征。

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-01 Epub Date: 2024-11-04 DOI: 10.1080/13697137.2024.2418492

Tiziana Fidecicchi, Marco Gambacciani

{"title":"Hyaluronic acid and erbium laser for the treatment of genitourinary syndrome of menopause.","authors":"Tiziana Fidecicchi, Marco Gambacciani","doi":"10.1080/13697137.2024.2418492","DOIUrl":"10.1080/13697137.2024.2418492","url":null,"abstract":"Objective: This study aimed to evaluate the effect of the vaginal erbium laser (VEL) in association with vaginal hyaluronic acid (HA) in postmenopausal women suffering from genitourinary syndrome of menopause (GSM).Methods: One hundred sexually active postmenopausal women were selected and divided into three groups using a block randomization method; 10 women declined to participate. The remaining women received three laser applications at 30-day intervals; 22 women dropped out for personal reasons or protocol violations. Group 1 (n = 25) received VEL treatment (XS Fotona Smooth®; Fotona, Slovenia) alone; Group 2 (n = 22) received daily vaginal HA tablets for 10 days after VEL treatment, followed by a twice a week administration during the follow-up period; and Group 3 (n = 21) received daily HA tablets for 10 days before the first VEL treatment and for 10 days after each laser application, followed by a twice a week administration for the follow-up period. Vaginal dryness and dyspareunia were assessed at the screening visit, before VEL treatment, after 1 and 3 months from the last laser treatment, using the visual analog scale. Data were analyzed using one-way analysis of variance and a linear mixed model for repeated measures. The post-hoc test for the interaction between time and treatment was performed using Bonferroni correction.Results: A significant (p < 0.001) improvement in both vaginal dryness and superficial dyspareunia was evident, with greater (p < 0.001) improvement in Group 2 and Group 3.Conclusions: The results suggest that vaginal HA administration can improve the VEL effects on GSM in postmenopausal women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"87-92"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142567581","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hyperandrogenism after menopause: diagnostic evaluation. 绝经后雄激素过多：诊断评估。

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-01 Epub Date: 2024-11-14 DOI: 10.1080/13697137.2024.2423874

Carolina Fux-Otta, Diana Torre, Peter Chedraui, Belén Melgarejo, Noelia Ramos, Mariana Di Carlo, Mariana Benzi, Victoria Banús, María Eugenia Estario, Susana Leiderman, Romina Gecchelin, Inés Bartolacci, Milena Tarletta, Cintya Ziperovich, Silvina Di Lella, Candelaria Aramayo, Lucila Martín, Celina Pereyra, Constanza Real, Patricia Dogliani, Mónica Ñañez, Mónica López, Gabriel Iraci, Gladys Fernández

{"title":"Hyperandrogenism after menopause: diagnostic evaluation.","authors":"Carolina Fux-Otta, Diana Torre, Peter Chedraui, Belén Melgarejo, Noelia Ramos, Mariana Di Carlo, Mariana Benzi, Victoria Banús, María Eugenia Estario, Susana Leiderman, Romina Gecchelin, Inés Bartolacci, Milena Tarletta, Cintya Ziperovich, Silvina Di Lella, Candelaria Aramayo, Lucila Martín, Celina Pereyra, Constanza Real, Patricia Dogliani, Mónica Ñañez, Mónica López, Gabriel Iraci, Gladys Fernández","doi":"10.1080/13697137.2024.2423874","DOIUrl":"10.1080/13697137.2024.2423874","url":null,"abstract":"Excessive androgen levels in women after menopause often result from an imbalance in ovarian steroid secretion: a rapid decline in estrogen secretion associated with a slow decrease in androgen secretion, compounded by a physiological decrease in sex hormone-binding globulin. Hyperandrogenism is associated with a higher risk of cardiovascular events and gynecological neoplasms, also impacting the emotional well-being of affected women. Therefore, the aim of these guidelines is to guide the clinical physician in the appropriate clinical and biochemical evaluation of hyperandrogenism after menopause, thus optimizing therapeutic outcomes. The most frequent consultation in this stage of life is facial hirsutism associated with hair loss. If the onset of signs is abrupt, severe, associated with virilization and accompanied by serum testosterone levels in the male range, it is necessary to rule out a tumoral origin. A thorough medical history guides the diagnosis. Determination of total testosterone using reliable methods and imaging studies are valid tools to assist when doubts arise in the differential diagnosis.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"61-68"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142615994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of a therapeutic lifestyle modification intervention on health-related quality of life and sexual functioning and cardiometabolic health in perimenopausal Chinese women: a randomized controlled trial. 治疗性生活方式改变干预对围绝经期中国妇女健康相关生活质量、性功能和心脏代谢健康的影响：一项随机对照试验

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-01 Epub Date: 2024-12-13 DOI: 10.1080/13697137.2024.2435879

Yuru Wang, Xiaoling Miao, Pramon Viwattanakulvanid

{"title":"Effects of a therapeutic lifestyle modification intervention on health-related quality of life and sexual functioning and cardiometabolic health in perimenopausal Chinese women: a randomized controlled trial.","authors":"Yuru Wang, Xiaoling Miao, Pramon Viwattanakulvanid","doi":"10.1080/13697137.2024.2435879","DOIUrl":"10.1080/13697137.2024.2435879","url":null,"abstract":"Objective: This study aimed to evaluate the effects of a therapeutic lifestyle modification (TLM) intervention on health-related quality of life, sexual functioning and cardiometabolic health in perimenopausal Chinese women.Method: The study was a randomized controlled trial (registration number: ChiCTR2300070648). Ninety-four perimenopausal women aged between 40 and 55 years were randomly assigned in a 1:1 ratio to receive the TLM intervention or usual care for 12 weeks. Menopause-specific Quality of Life (MENQOL), Female Sexual Function Index (FSFI), pelvic floor muscle strength (PFMS) and composite cardiometabolic indicators were evaluated at baseline and post intervention.Results: After 12 weeks, linear mixed-effects models showed that the TLM intervention led to a statistically significant improvement in MENQOL (-0.60, 95% confidence interval [CI] - 0.80 to -0.41), FSFI (3.82, 95% CI 2.03 to 5.61), resting heart rate (-5.44, 95% CI -10.40 to -0.48), waist circumference(-3.14, 95% CI -4.15 to -2.13) and body fat percentage (-4.25, 95% CI -6.92 to -1.58) compared to the control group. There were also statistically significant differences between the intervention (TLM) group and the control group in the proportions of PFMS (p = 0.006).Conclusion: The TLM intervention effectively improved menopause-specific quality of life in midlife women, supported by enhancements in female sexual functioning and cardiometabolic health status.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"28-39"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142821982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Low-dose and ultra-low-dose estradiol and dydrogesterone in postmenopause: an analysis by body mass index. 绝经后低剂量和超低剂量雌二醇和地屈孕酮：按体重指数分析。

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-01 Epub Date: 2024-10-30 DOI: 10.1080/13697137.2024.2418497

Mulan Ren, Qi Yu, Marcelo Graziano Custodio, Tommaso Simoncini, Rossella E Nappi, Tetiana Tatarchuk, Elke Kahler, Tony Piha, John C Stevenson

{"title":"Low-dose and ultra-low-dose estradiol and dydrogesterone in postmenopause: an analysis by body mass index.","authors":"Mulan Ren, Qi Yu, Marcelo Graziano Custodio, Tommaso Simoncini, Rossella E Nappi, Tetiana Tatarchuk, Elke Kahler, Tony Piha, John C Stevenson","doi":"10.1080/13697137.2024.2418497","DOIUrl":"10.1080/13697137.2024.2418497","url":null,"abstract":"Objective: Oral, low-dose and ultra-low-dose continuous combined 17β-estradiol (E) plus dydrogesterone (D) reduce vasomotor symptoms (VMS) in postmenopausal women.Methods: Two phase 3, double-blind studies were included. In the European study, postmenopausal women were randomized 2:1:2 to receive E0.5 mg/D2.5 mg (ultra-low dose), E1 mg/D5 mg (low dose) or placebo for 13 weeks. In the Chinese study, women were randomized 1:1 to receive E0.5 mg/D2.5 mg or placebo for 12 weeks. Post-hoc endpoints assessed in body mass index (BMI) subgroups (<25 kg/m2; ≥25 kg/m2) included number of hot flushes and moderate-to-severe hot flushes per day, and the proportion of women with amenorrhea.Results: A total of 640 women were included. At the end of treatment, the mean (95% confidence interval) numbers of daily hot flushes were significantly lower (p ≤ 0.05) for all treatment groups versus placebo, with E0.5 mg/D2.5 mg (BMI < 25 kg/m2: 2.5 [1.9, 3.1]; BMI ≥ 25 kg/m2: 3.2 [2.5, 3.8]) and E1 mg/D5 mg versus placebo (BMI < 25 kg/m2: 2.7 [1.2, 4.2]; BMI ≥ 25 kg/m2: 2.3 [1.1, 3.5]) than with placebo (BMI < 25 kg/m2: 4.4 [3.8, 50]; BMI ≥ 25 kg/m2: 4.2 [3.6, 4.9]). A similar pattern was seen for moderate-to-severe hot flushes. The amenorrhea rate was high (79-98%) across both studies and BMI subgroups.Conclusion: Oral, ultra-low-dose continuous combined E0.5 mg/D2.5 mg and low-dose continuous combined E1 mg/D5 mg alleviated postmenopausal VMS compared with placebo, irrespective of BMI.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"21-27"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142544081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Systemic hormone therapy after breast and gynecological cancers: an Italian expert group consensus opinion. 乳腺癌和妇科癌症术后的全身激素治疗：意大利专家组的共识意见。

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-01 Epub Date: 2024-11-06 DOI: 10.1080/13697137.2024.2418503

Angelo Cagnacci, Paola Villa, Giuseppina Paola Grassi, Nicoletta Biglia, Marco Gambacciani, Costantino Di Carlo, Francesca Nocera, Salvatore Caruso, Angelamaria Becorpi, Stefano Lello, Anna Maria Paoletti

{"title":"Systemic hormone therapy after breast and gynecological cancers: an Italian expert group consensus opinion.","authors":"Angelo Cagnacci, Paola Villa, Giuseppina Paola Grassi, Nicoletta Biglia, Marco Gambacciani, Costantino Di Carlo, Francesca Nocera, Salvatore Caruso, Angelamaria Becorpi, Stefano Lello, Anna Maria Paoletti","doi":"10.1080/13697137.2024.2418503","DOIUrl":"10.1080/13697137.2024.2418503","url":null,"abstract":"The specific Italian Group of Study of the Menopause formulated a consensus opinion on the use of estrogen therapy (ET) or combined estro-progestin hormone therapy (HT) after breast and gynecological cancers. This consensus is based on the risk of recurrence of the specific cancer during ET/HT, the presence of steroid receptors in cancer cells, the use of adjuvant hormone therapies and data on the use of ET/HT after cancer. The following positions were reached. ET/HT can be used after vulvar cancers and melanoma, but with great caution after the rare adenocarcinomas. ET/HT can be used after cervical cancer, but ET should be used with caution after adenocarcinomas. ET/HT can be used after International Federation of Obstetrics and Gynecology (FIGO) stage I-II estrogen-dependent endometrial cancers, except in Black women, and can probably be used after estrogen-independent endometrial cancers. ET/HT cannot be administered or should be used with great caution after most uterine sarcomas. ET/HT can probably be used after ovarian neoplasms except for granulosa cell tumors, and with great caution after low-grade serous ovarian carcinoma and serous borderline ovarian tumors. ET/HT can be used with great caution in women after estrogen receptor (ER)/progesterone receptor (PR)-positive breast cancer and is probably allowed after ER/PR-negative breast cancer.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"4-14"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142582142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Investigating the triglyceride-glucose index in postmenopausal osteoporosis. 绝经后骨质疏松症患者甘油三酯-葡萄糖指数的研究。

IF 2.9 4区医学

Climacteric Pub Date : 2025-02-01 Epub Date: 2024-12-05 DOI: 10.1080/13697137.2024.2429430

Busra Korpe, Caner Kose, Sumeyye Mermi, Samet Kutluay Ergorun, Huseyin Levent Keskin

{"title":"Investigating the triglyceride-glucose index in postmenopausal osteoporosis.","authors":"Busra Korpe, Caner Kose, Sumeyye Mermi, Samet Kutluay Ergorun, Huseyin Levent Keskin","doi":"10.1080/13697137.2024.2429430","DOIUrl":"10.1080/13697137.2024.2429430","url":null,"abstract":"Objective: This retrospective study aims to assess the association of the triglyceride-glucose index (TyG index) with postmenopausal osteoporosis and investigate longitudinal changes in TyG index levels in relation to osteoporosis risk.Methods: Out of 704 women, after excluding those with osteopenia, a total of 517 patients who met the inclusion criteria were included. Participants were categorized based on T-scores derived from lumbar spine dual-energy X-ray absorptiometry scans. Demographic data, biochemical parameters and TyG index levels were analyzed. Logistic regression, correlation analysis and receiver operating characteristic (ROC) curve analysis were employed for statistical evaluation.Results: The osteoporosis group (n = 254) exhibited significantly higher TyG index and triglyceride levels compared to controls (n = 263). Longitudinal analysis revealed significant increases in TyG index levels among women developing osteoporosis over time. ROC analysis demonstrated the TyG index's accuracy for osteoporosis (first TyG area under the curve [AUC]: 0.767, second TyG AUC: 0.818, p < 0.001). Regression analyses identified the TyG index as a significant factor associated with osteoporosis (odds ratio: 39.468, 95% confidence interval: 12.884-120.903, p < 0.001).Conclusions: The TyG index emerges as a valuable indicator for postmenopausal osteoporosis. These results emphasize the need for integrating metabolic health indicators into osteoporosis management strategies, warranting further research into targeted interventions.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"81-86"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Not just sex: other roles for testosterone in women. 不仅仅是性：女性体内的睾丸激素还有其他作用。

IF 2.9 4区医学

Climacteric Pub Date : 2025-01-17 DOI: 10.1080/13697137.2024.2445301

Susan R Davis

引用次数: 0