Climacteric最新文献

{"title":"Menarche, menopause, reproductive life span and menopause-specific quality of life: a cohort study.","authors":"Zhuolin Xie, Ruiyi Tang, Feiling Huang, Penghui Feng, Yubo Fan, Xuanjin Yang, Jingbo Huang, Xiaonan Ma, Shiman Yuan, Rong Chen","doi":"10.1080/13697137.2026.2702817","DOIUrl":"10.1080/13697137.2026.2702817","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the associations of menarche age, menopause age and reproductive life span with menopausal symptoms in Chinese women.</p><p><strong>Methods: </strong>The prospective, longitudinal study included 557 midlife Chinese women. Menopausal symptoms were evaluated through the Menopause-Specific Quality of Life (MENQOL) questionnaire, covering vasomotor symptoms (VMS), psychosocial, physical and sexual domains. Generalized estimating equation models were used to estimate the crude and adjusted mean differences (<i>β</i>) and 95% confidence intervals (CI).</p><p><strong>Results: </strong>Mean menarche and menopause ages were 13.92 ± 1.62 and 50.56 ± 3.20 years, with a mean reproductive life span of 36.64 ± 3.56 years. Age at menarche was not associated with MENQOL domain scores. Earlier menopause and shorter reproductive life span were associated with higher adjusted sexual-domain scores, with significant differences for menopause before age 45 years (<i>β</i> = 0.83, 95% CI: 0.21, 1.44) and reproductive life span <30 years (<i>β</i> = 0.98, 95% CI: 0.21, 1.74). These sexual-domain associations were attenuated after adjustment for time since menopause, whereas associations with higher VMS scores became apparent in postmenopausal analyses. No significant associations were observed for psychosocial or physical-domain scores.</p><p><strong>Conclusion: </strong>Earlier menopause and shorter reproductive life span were associated with MENQOL-assessed sexual-domain discomfort, partly explained by time since menopause. Additional postmenopausal analyses also linked these factors to greater VMS burden.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"821-830"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683452","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Distinguishing vasomotor events from symptom appraisal in CBT trials for menopause.","authors":"Yuquan Yuan, Chengzhi Zhao","doi":"10.1080/13697137.2026.2708569","DOIUrl":"10.1080/13697137.2026.2708569","url":null,"abstract":"","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"837-838"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905147","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prospective observational study of denosumab in postmenopausal women over 3 years: a Singapore study.","authors":"Mei Tuan Chua, Qian Wen Sng, Jean-Jasmin Mi-Li Lee, Seng Bin Ang","doi":"10.1080/13697137.2026.2732666","DOIUrl":"https://doi.org/10.1080/13697137.2026.2732666","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate treatment outcomes in postmenopausal women following 3 years of denosumab therapy, primarily assessing bone mineral density (BMD) changes post treatment and secondarily evaluating treatment-related adverse events and complications.</p><p><strong>Method: </strong>The prospective observational study comprised 318 postmenopausal women (aged 43-90 years) who completed the 3-year denosumab therapy. BMD measurements at the lumbar spine, femoral neck and total hip were assessed. Multivariate analysis was conducted to identify factors influencing BMD response to therapy whilst adverse events were systematically monitored throughout treatment.</p><p><strong>Results: </strong>Mean age at baseline was 68 years. The mean baseline BMD <i>T</i>-score was -1.9 for lumbar spine, -2.4 for neck of femur (NOF) and -2.1 for total hip. After 3 years of denosumab therapy, mean percentage changes in BMD were 6.95% (standard deviation [SD] 6.48), 3.89% (SD 5.89) and 4.77% (SD 5.46) for the lumbar spine, NOF and total hip, respectively. Lower baseline BMD <i>T</i>-scores were associated with high responder status at all skeletal sites. High body mass index was associated with greater treatment response at NOF and total hip. Prior bisphosphonate treatment was associated with lower responder status at selected skeletal sites. Musculoskeletal pain was the most common adverse event (<i>n</i> = 19, 6%). One case of osteonecrosis of the jaw occurred in a patient with prior alendronate exposure.</p><p><strong>Conclusions: </strong>This is the first study to evaluate the effectiveness of denosumab among postmenopausal women with osteoporosis in Singapore. Our findings demonstrate that denosumab's ability to enhance BMD is consistent with the efficacy demonstrated in global clinical trials, supporting its use in the local clinical setting.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-14"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149105009","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Portuguese osteopaths' perceptions on the management of musculoskeletal conditions in menopausal women.","authors":"João Espírito Santo, João Moita, Jorge E Esteves, Alexandre Nunes","doi":"10.1080/13697137.2026.2678370","DOIUrl":"10.1080/13697137.2026.2678370","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine Portuguese osteopaths' perceptions, confidence and approaches to managing musculoskeletal conditions in menopausal women.</p><p><strong>Method: </strong>A nationwide cross-sectional online survey was conducted among osteopaths registered with the Portuguese Central Administration of the Health System. A 36-item questionnaire, adapted from validated osteopathic instruments, assessed demographics, attitudes, clinical confidence, therapeutic strategies and barriers to menopause-related musculoskeletal management. The primary outcome measures were osteopaths' attitudes, confidence and therapeutic strategies regarding the relevance of menopause to musculoskeletal health.</p><p><strong>Results: </strong>Data from 258 osteopaths were analyzed. Most respondents recognized menopause as relevant to musculoskeletal health (95%) and reported frequent clinical contact with menopausal women (58%). Mobilization, fascial and soft-tissue techniques were commonly used, whereas high-velocity low-amplitude thrusts were less frequent. Confidence in treatment and patient education was moderate to high, although 36% felt under-informed about menopause and musculoskeletal interactions. Lack of clinical guidelines (59%) and limited research availability (75%) were the main barriers. Most participants (81%) reported a need for advanced training in menopause management. Female osteopaths scored significantly higher than males in perceptions of menopause and musculoskeletal conditions (<i>p</i> = 0.015), clinical experience and therapeutic approaches (<i>p</i> = 0.001), and competences in osteopathic practice (<i>p</i> = 0.001).</p><p><strong>Conclusion: </strong>Portuguese osteopaths, particularly women, appear aware of and engaged in managing menopause-related musculoskeletal conditions, adapting manual therapy and educational approaches to patients' needs. However, limited knowledge and the absence of structured clinical guidance may hinder consistent, evidence-informed care. Targeted education and clinical protocols may strengthen osteopathic support for women's musculoskeletal health during midlife.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"776-785"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148263426","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported outcome data from a randomized phase II study (STARLIGHT) of fezolinetant in women in Japan with vasomotor symptoms associated with menopause.","authors":"Kiyoshi Takamatsu, Takashi Miki, Kentaro Miyazaki, Atsuki Hashimoto, Antonia Morga, Xuegong Wang","doi":"10.1080/13697137.2026.2664751","DOIUrl":"10.1080/13697137.2026.2664751","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to report results of exploratory patient-reported outcomes (PROs) from the STARLIGHT study.</p><p><strong>Method: </strong>Perimenopausal/postmenopausal women aged ≥40 to ≤65 years from 36 centers in Japan seeking treatment/relief for vasomotor symptoms (VMS) associated with menopause were randomized 1:1:1, stratified by menopausal status, to receive fezolinetant 15 or 30 mg or placebo orally once daily for 12 weeks. The Patient-Reported Outcomes Measurement Information System Sleep Disturbance - Short Form 8b (PROMIS SD-SF 8b) total score, Menopause-Specific Quality of Life (MENQOL) total and domain scores, and Patient Global Impression of Change in Vasomotor Symptoms (PGI-C VMS) assessed the effect of fezolinetant on health-related quality of life (HRQoL).</p><p><strong>Results: </strong>In total, 147 participants were randomized (placebo, <i>n</i> = 47; fezolinetant 15 mg, <i>n</i> = 53; fezolinetant 30 mg, <i>n</i> = 47). Improvements from baseline in the PROMIS SD-SF 8b total score and MENQOL total score were observed in the fezolinetant and placebo groups at weeks 4, 8 and 12. A higher proportion of participants in the fezolinetant 15 mg and fezolinetant 30 mg groups versus placebo reported improvement from baseline in the PGI-C VMS at weeks 4, 8 and 12.</p><p><strong>Conclusion: </strong>Fezolinetant was associated with improvements in PROs (PROMIS SD-SF-8b, MENQOL and PGI-C VMS); however, these analyses were exploratory and not powered for confirmatory hypothesis testing.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"704-711"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147970995","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency, distress and interference in CBT for menopausal vasomotor symptoms: response to commentary.","authors":"Jung Yoon Park, Mee-Ran Kim","doi":"10.1080/13697137.2026.2719017","DOIUrl":"10.1080/13697137.2026.2719017","url":null,"abstract":"","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"839-840"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148905131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A biopsychosocial framework for scalable menopause care: integrating cognitive behavioral therapy and digital therapeutics.","authors":"Andrew Grannell, Pia Wuelfing, Myra S Hunter","doi":"10.1080/13697137.2026.2688265","DOIUrl":"10.1080/13697137.2026.2688265","url":null,"abstract":"<p><p>Menopause is a natural life stage characterized by biological, psychological and social changes that collectively influence women's health and quality of life. Despite the prevalence of vasomotor disturbances, sleep disruption, mood changes and genitourinary complaints, access to evidence-based menopause care remains limited by inadequate models of care, polarized social narratives and limited awareness among healthcare providers. The biopsychosocial model offers a holistic framework for understanding menopause, emphasizing that symptom burden is shaped not only by hormonal changes but also by individual health beliefs, coping strategies, lifestyle and sociocultural context. Evidence-based interventions, including menopausal hormone therapy and cognitive behavioral therapy (CBT), are complementary tools that can be offered separately or in combination. Digital health solutions, in particular prescription and non-prescription digital therapeutics (DTx), provide an opportunity to expand access to CBT and other evidence-based interventions at scale, addressing existing barriers such as limited availability and long waiting times. Countries such as Germany, France, the UK and the USA are beginning to develop reimbursement and regulatory pathways to support prescription DTx, highlighting opportunities for global implementation. Reframing menopause through a biopsychosocial lens, integrating scalable behavioral and pharmacological interventions, and leveraging digital technologies represent a critical pathway toward equitable, personalized and effective care for women.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"699-703"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148429961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multidimensional menopausal symptom burden in Singapore - MARIE work package 2a population analysis.","authors":"Ieera Madan Aggarwal, Vindya Pathiraja, Farah Safdar Husain, Raksha Aiyappan, Manisha Mathur, Rajeswari Kathirvel, Rukshini Puvanendran, Jie Sun, Julie Taylor, Lucky Saraswat, Sharron Hinchliff, Kristina Potocnik, Nick Panay, Carol Atkinson, Vikram Talaulikar, Jeevan Dhanarisi, George Uchenna Eleje, Lamya Al-Kharusi, Nihal Al-Riyami, Teck Hock Toh, Muhammad Irfan, Rabia Kareem, Cristina Laguna Benetti-Pinto, Bernard Mbwele, David Chibuike Ikwuka, Helen Felicity Kemp, Jian Shi, Sohier Elneil, Peter Phiri, Gayathri Delanerolle","doi":"10.1080/13697137.2026.2685623","DOIUrl":"10.1080/13697137.2026.2685623","url":null,"abstract":"<p><strong>Objective: </strong>Menopause is a multidimensional health transition associated with physical, psychological and social consequences. Evidence from Asian settings remains limited, and symptom burden is often examined using single instruments rather than integrated severity measures. This study quantified menopausal symptom burden in Singapore and developed composite indices capturing overall symptom severity and cumulative burden.</p><p><strong>Method: </strong>Baseline and follow-up data from the Singapore arm of a multi-site menopause study were analyzed. Participants self-reported menopausal stage and type. Symptoms were assessed using validated psychometric instruments. The Singapore Menopause Symptom Severity Score (SMSS-SG) integrated standardized symptom totals into a single severity metric. A Cumulative Burden Index for Singapore (CBI-SG) combined biological symptom severity (SMSS-SG), psychological burden, socioeconomic disadvantage and health-system barriers on a common scale. Descriptive analyses, non-parametric comparisons and validation assessments were performed.</p><p><strong>Results: </strong>Menopausal symptom burden was common and heterogeneous. Musculoskeletal and urogenital symptoms were the most severe, alongside high prevalence of sleep and mood-related symptoms. Overall severity peaked during perimenopause and remained clinically relevant in menopause and postmenopause. Surgical menopause was associated with higher symptom severity and cumulative burden than natural menopause, whereas medically induced menopause showed lower median severity. The SMSS-SG demonstrated good internal consistency and known-group validity, and both indices were inversely associated with health-related quality of life.</p><p><strong>Conclusion: </strong>Menopausal symptom burden in Singapore is substantial and multidimensional. Composite severity and cumulative burden indices support epidemiological assessment and may support future symptom-led approaches to epidemiological surveillance, service planning and hypothesis generation within menopause research.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"747-759"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148410626","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Photobiomodulation and pelvic floor training for genitourinary syndrome: RCT results.","authors":"Lívia Oliveira Bezerra, Edson Silva-Filho, Maria Leticia Araújo Silva de Carvalho, Patrícia Froes Meyer, Palloma Rodrigues de Andrade, Maria Thereza Albuquerque Barbosa Cabral Micussi","doi":"10.1080/13697137.2026.2702818","DOIUrl":"10.1080/13697137.2026.2702818","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the effects of photobiomodulation (PBM) alone and in combination with pelvic floor muscle training (PFMT) on pelvic floor muscle (PFM) function, sexual and urinary function, and quality of life in women with genitourinary syndrome of menopause.</p><p><strong>Method: </strong>The three-arm clinical trial included women aged 45-65 years who had experienced natural menopause for at least 1 year. Participants were randomized into three groups: PFMT + active PBM, PFMT + sham PBM and isolated PFMT. Interventions lasted 8 weeks, with participants attending two 50-min sessions per week. Outcomes were assessed before and after the 16th session.</p><p><strong>Results: </strong>Although manometry showed no significant differences between groups, the intervention group demonstrated greater numerical improvement. The Female Sexual Function Index (FSFI) total score differed significantly between the PFMT + active PBM and PFMT + sham PBM groups (mean difference = 4.55; 95% confidence interval: 0.57, 8.52; <i>d</i> = 1.05). Significant between-group differences were also observed in the orgasm subdomain in favor of the PFMT + active PBM group compared to the PFMT + sham PBM group. The International Consultation on Incontinence Questionnaire - short form (ICIQ-SF) indicated a clinically significant improvement of 3.06 points in the PFMT + active PBM group compared to the PFMT + sham PBM group following the intervention.</p><p><strong>Conclusion: </strong>Active PBM combined with PFMT showed greater but non-significant improvements in PFM pressure, urinary function and quality of life, while significantly improving only sexual function.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"786-794"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148683538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chronic pain at midlife.","authors":"Angela Mailis, Seng Bin Ang, Tania Di Renna, Marina Marks Kazatsker, E Anne MacGregor, Giulia Misasi, Juliana Poli, Tommaso Simoncini, Wendy Wolfman, Rossella E Nappi","doi":"10.1080/13697137.2026.2722558","DOIUrl":"10.1080/13697137.2026.2722558","url":null,"abstract":"<p><p>Chronic pain disproportionately affects women and reproductive milestones influence its clinical manifestation. Mechanistic pathways underlying pain are determined by numerous biopsychosocial factors, the most important being age, hormonal changes and mental health. Menopause-related changes in estradiol interact bidirectionally with musculoskeletal degeneration, neuro-immune sensitization, neuroendocrine responses and other intrapersonal and socio-cultural vulnerabilities, collectively amplifying pain perception and maintenance. Approximately half of midlife women experience chronic pain often with overlapping chronic pain syndromes (e.g. fibromyalgia, migraine, chronic pelvic pain) requiring an integrated management approach. The menopausal transition may coincide with an increased vulnerability to pain and vasomotor symptoms, sleep disruptions, mood disturbances, brain fog and fatigue, which may contribute overall to the pain experience. Chronic pain is a major health issue that is often under-recognized, underdiagnosed and inadequately treated. The aim of the 2026 International Menopause Society White Paper is to provide an overview of the current evidence on the most common midlife chronic pain syndromes causing significant disability and impairing quality of life. This article provides an updated synthesis of chronic pain in menopausal women, encompassing its neurobiological mechanisms and clinical management, and the influence of cultural factors, lifestyle interventions and hormonal therapies. The goal of the White Paper is to raise awareness of midlife women's pain experience and to support clinicians and policymakers in implementing culturally sensitive, personalized approaches. A proactive attitude is essential to guide women through multidisciplinary pathways of care that reflect the multidimensional nature of chronic pain, with the ultimate goal of promoting healthy longevity and gender equity.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"648-668"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148918652","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}