Intraocular pressure and central corneal thickness in premenopausal and postmenopausal women: a systematic review and meta-analysis.

IF 3.2 4区医学 Q1 OBSTETRICS & GYNECOLOGY

Climacteric Pub Date : 2025-08-14 DOI:10.1080/13697137.2025.2539856

Parva Pourbagherkhah, Mohammad Farjami, Hemn Baghban Jaldian

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引用次数: 0

Abstract

Objective: This study aimed to systematically evaluate and quantify the impact of menopausal status on intraocular pressure (IOP) and central corneal thickness (CCT) in women, through a comparative meta-analysis.

Method: A systematic search was conducted across PubMed, Scopus, Web of Science and the Cochrane Library up to 15 April 2025, following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Eligible studies included original research comparing IOP and/or CCT between premenopausal and postmenopausal women. Meta-analysis was conducted using a random-effects model, and heterogeneity was assessed via I², τ² and H² statistics.

Results: Ten studies were analyzed in this meta-analysis, including data from premenopausal and postmenopausal women (totaling 999 eyes). The pooled results indicated that postmenopausal women had significantly higher IOP and reduced CCT compared to premenopausal women. Despite high heterogeneity (I² = 97.17% for CCT, I² = 84.20% for IOP), the direction of effect was consistent across most studies. The hormonal decline associated with menopause, particularly reduced estrogen levels, appears to affect corneal structure.

Conclusion: Menopause is associated with elevated IOP and decreased CCT, likely due to hormonal alterations, notably estrogen deficiency. Menopausal status may be a relevant factor in ocular assessments and could have implications for risk assessment in conditions such as glaucoma.

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绝经前和绝经后妇女的眼压和中央角膜厚度：一项系统回顾和荟萃分析。

目的：本研究旨在通过一项比较荟萃分析，系统评估和量化绝经状态对女性眼压（IOP）和角膜中央厚度（CCT）的影响。方法：系统检索PubMed、Scopus、Web of Science和Cochrane Library，检索截止到2025年4月15日，遵循PRISMA （Preferred Reporting Items for systematic Reviews and meta - analysis）指南。符合条件的研究包括比较绝经前和绝经后妇女IOP和/或CCT的原始研究。采用随机效应模型进行meta分析，采用I2、τ2和H2统计量评估异质性。结果：本荟萃分析分析了10项研究，包括绝经前和绝经后妇女（共999只眼睛）的数据。综合结果表明，与绝经前妇女相比，绝经后妇女的IOP显著升高，CCT显著降低。尽管异质性很高（CCT的I2 = 97.17%, I2 = 84.20%），但大多数研究的影响方向是一致的。与更年期相关的激素下降，特别是雌激素水平降低，似乎会影响角膜结构。结论：绝经与IOP升高和CCT下降有关，可能是由于激素改变，特别是雌激素缺乏。绝经状态可能是眼科评估的一个相关因素，可能对青光眼等疾病的风险评估有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.