Climacteric最新文献

{"title":"Response to the comment by Ömer Faruk Öz et al.","authors":"Milla Sipilä, Liisu Saavalainen, Oskari Heikinheimo","doi":"10.1080/13697137.2026.2722833","DOIUrl":"10.1080/13697137.2026.2722833","url":null,"abstract":"","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"843"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149012007","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Correction.","authors":"","doi":"10.1080/13697137.2026.2739064","DOIUrl":"10.1080/13697137.2026.2739064","url":null,"abstract":"","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"844"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"149079985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Postpartum status and emotional health in women aged ≥45 years during the menopausal transition: a prospective observational study.","authors":"Pilar Prats Rodríguez, Sandra García Lumbreras, Pascual García-Alfaro, Luciana Bergamaschi, Sandra García Martinez, Sonia Baulies Caballero, Sonia Rombaut Segarra, Silvia Cabrera Diaz","doi":"10.1080/13697137.2026.2671767","DOIUrl":"10.1080/13697137.2026.2671767","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to describe associations between pregnancy, postpartum status and emotional health in women aged ≥45 years undergoing the menopausal transition.</p><p><strong>Method: </strong>The prospective observational study included 71 women aged ≥45 years: 36 postpartum participants and 35 age-matched controls who had not given birth in the preceding 2 years. Participants completed the Cervantes Short-Form Scale (quality of life), Beck Depression Inventory-II (BDI-II) and Patient Health Questionnaire-9 (PHQ-9) at baseline, 12 months and 24 months.</p><p><strong>Results: </strong>Participants had a mean age of 47.3 ± 2.0 years; most were employed, in stable relationships and university educated. Nearly all postpartum participants (97.2%) conceived via assisted reproductive technologies. No baseline differences were found between groups. At 12 and 24 months, postpartum women had higher BDI-II scores than controls (<i>p</i> = 0.010 and <i>p</i> = 0.015, respectively). In multivariable analysis adjusting for baseline scores, age and parity, this association remained significant (<i>p</i> < 0.001). No significant associations were observed for PHQ-9 or Cervantes scores after adjustment.</p><p><strong>Conclusions: </strong>Among midlife women, postpartum status was associated with higher depressive symptom scores on the BDI-II but not on other measures. These findings are preliminary and should be interpreted as hypothesis-generating. Larger studies are needed to confirm these associations and identify potential contributing factors.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"712-719"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148148706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Humic acid from biomass attenuates ovariectomy-induced metabolic and bone changes in mice.","authors":"Eric Francelino Andrade, Hellen Paulo Silva, Thays Cristina Dos Santos, Karen Rodrigues Lima, Maíra Gabrielle de Abreu Ribeiro, Pedro Gustavo Machado, Maria Luiza Nonato Salvador, Jaqueline do Carmo Lima, Débora Ribeiro Orlando, Leonara Teixeira Alves, Elizabethe Adriana Esteves, Marco Fabrício Dias-Peixoto, Alan Rodrigues Teixeira Machado, Leonardo Barros Dobbss, Luciano José Pereira","doi":"10.1080/13697137.2026.2688264","DOIUrl":"10.1080/13697137.2026.2688264","url":null,"abstract":"<p><strong>Objective: </strong>Estrogen deficiency promotes metabolic dysfunction and bone loss. This study thus evaluated the effects of biomass-derived humic acid (HA) on ovariectomy-induced metabolic and bone alterations in mice.</p><p><strong>Method: </strong>Female C57BL/6 mice (<i>n</i> = 6/group) were assigned to Sham, Sham + HA, ovariectomized (OVX) or OVX + HA groups. Estrogen deprivation was induced by bilateral ovariectomy. After a 14-day recovery period, HA (80 mg/kg/day) was administered orally for 28 days. Body mass, food intake, serum glucose, lipid profile, creatinine, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) were measured. Tibial calcium and phosphorus content and bone surface topography were assessed by scanning electron microscopy coupled with energy dispersive X-ray spectroscopy, and receptor activator of nuclear factor-κB ligand (RANKL) and osteoprotegerin (OPG) staining intensity in the femoral head was evaluated by immunohistochemistry. Data were analyzed using two-way analysis of variance with the Bonferroni post hoc test.</p><p><strong>Results: </strong>OVX animals presented increased body mass gain, fasting glucose, dyslipidemia, creatinine and AST compared with Sham animals (<i>p</i> < 0.05). HA attenuated these alterations (<i>p</i> < 0.05) and reduced body weight gain. OVX-induced reductions in tibial mineral content and increased bone porosity were partially reversed by HA (<i>p</i> < 0.05), with a descriptive shift toward a less pro-resorptive RANKL/OPG staining profile.</p><p><strong>Conclusion: </strong>Biomass-derived HA mitigates metabolic dysfunction and bone loss from estrogen deficiency, supporting its potential as adjunct therapy.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"803-811"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148444791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"'Women are born with pain built in' - what this means to the modern menopause narrative.","authors":"Rossella E Nappi","doi":"10.1080/13697137.2026.2720370","DOIUrl":"10.1080/13697137.2026.2720370","url":null,"abstract":"","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"645-647"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148918605","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparing aerobic and resistance training in estrogen deficiency: bone and muscle adaptations.","authors":"Pedro Gustavo Machado, Juliana Cristina Dos Reis Canaan, Luciana Botelho Ribeiro, José Victor Mauricio de Jesus, Heloisa Oliveira Dos Santos, Natália Oliveria Bertolini, Ivam Moreira de Oliveira Júnior, Wilson Vicente Souza Pereira, Eric Francelino Andrade, Luciano José Pereira","doi":"10.1080/13697137.2026.2694475","DOIUrl":"10.1080/13697137.2026.2694475","url":null,"abstract":"<p><strong>Objective: </strong>The reduction in bone mass and deterioration of bone microarchitecture are hallmark consequences of estrogen deficiency during menopause, increasing susceptibility to osteopenia and osteoporosis. Physical exercise is recognized as an effective non-pharmacological strategy; however, the comparative effects of different exercise modalities on bone remodeling and muscle-bone crosstalk remain unclear. This study investigated the effects of aerobic and resistance training on femoral bone metabolism and skeletal muscle adaptations in ovariectomized (OVX) mice.</p><p><strong>Method: </strong>Sixty-four female C57BL/6J mice underwent ovariectomy or sham surgery and were allocated to sedentary, aerobic (treadmill running) or resistance (ladder climbing) training protocols for 8 weeks. Bone histological and histochemical analyses, skeletal muscle morphology and gene expression in bone and muscle tissues were evaluated.</p><p><strong>Results: </strong>Both training modalities significantly increased the osteoblast number and reduced the osteoclast density in OVX animals compared with sedentary controls (<i>p</i> < 0.05), accompanied by a reduction in the RANKL/osteoprotegerin (OPG) ratio (<i>p</i> < 0.001). Resistance training induced more pronounced effects, including higher osteocyte density (<i>p</i> < 0.01), greater RUNX2 expression (<i>p</i> < 0.001) and stronger suppression of osteoclastogenesis. In parallel, resistance training significantly increased the muscle fiber cross-sectional area (<i>p</i> < 0.05) and upregulated IGF-1 (<i>p</i> < 0.01) and FNDC5 expression (<i>p</i> < 0.05).</p><p><strong>Conclusion: </strong>These findings demonstrate that exercise mitigates estrogen deficiency-induced bone deterioration, with resistance training exerting superior effects on bone remodeling and musculoskeletal integration.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"812-820"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148560970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopausal hormone therapy after endometriosis-related hysterectomy: clinical reflections.","authors":"Ömer Faruk Öz, Can Dinç, Selen Doğan, Nasuh Utku Doğan, Murat Özekinci, İnanç Mendilcioğlu","doi":"10.1080/13697137.2026.2713389","DOIUrl":"10.1080/13697137.2026.2713389","url":null,"abstract":"","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"841-842"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148975996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mapping menopause education for healthcare professionals: a scoping review.","authors":"Catriona Keye, Margaret Murphy, Mohamad M Saab, Michelle O'Driscoll","doi":"10.1080/13697137.2026.2676683","DOIUrl":"10.1080/13697137.2026.2676683","url":null,"abstract":"<p><p>Menopause is a natural life stage with substantial impacts on women's quality of life and long-term health. Education on menopause for healthcare professionals (HCPs) remains limited and inconsistently embedded across health disciplines. This scoping review mapped current evidence on menopause education, including available programs, delivery approaches and extent of curricular integration. Following the Joanna Briggs Institute methodology and PRISMA-ScR guidelines, a search of six databases and gray literature (last searched May 2025) identified original research evaluating menopause-specific education for undergraduate and postgraduate HCPs. Data were synthesized using deductive and inductive analyses. Of 5034 records identified, 14 studies met the inclusion criteria: nine evaluated educational interventions and five examined curricular provision. Most studies originated from the USA and focused on medical residents. Education formats varied widely, including structured curricula, case-based learning, online modules, telemedicine encounters and peer-supported platforms. Core content commonly addressed menopause physiology, symptom management and hormone therapy, while long-term health implications and equity-focused content were infrequently included. Interventions consistently improved knowledge, confidence and preparedness for menopause care. Despite widespread recognition of its importance, menopause education remains inadequately integrated across healthcare training. Standardized, multidisciplinary and equity-focused menopause education frameworks are urgently required to strengthen clinical competence and improve care for midlife women.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"680-688"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148301044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of menopause hormone therapy in borderline ovarian tumor survivors: a systematic review and meta-analysis.","authors":"Javier Mejia-Gomez, Melissa Tigert, Michelle Jacobson, Elizabeta Shprits, Alison K Shea, Eleni Philippopoulos, Joanne Kotsopoulos, Adam Bridger, Nichole Sanchez Diaz, Pugaliya Puveendrakumaran, Nada Shaltout, Harsukh Benipal, Carys Sosea, Brenna Leslie, Ariel Garzon, Wendy Wolfman, Tiffany Zigras","doi":"10.1080/13697137.2026.2675561","DOIUrl":"10.1080/13697137.2026.2675561","url":null,"abstract":"<p><strong>Objective: </strong>Borderline ovarian tumors (BOTs) are heterogeneous primary epithelial lesions defined by atypical epithelial proliferation without stromal invasion, accounting for approximately 15% of primary ovarian neoplasms. Menopausal hormone therapy (MHT) treats vasomotor and genitourinary symptoms in postmenopausal women, yet its relationship with ovarian neoplasia, especially BOTs, remains uncertain. This systematic review evaluates the association between MHT and BOT outcomes.</p><p><strong>Method: </strong>Five databases were searched from inception to August 2025. Included studies were assessed for type of MHT, duration, and recurrences where reported. Risk of bias was assessed with the Newcastle-Ottawa Scale and certainty of evidence with GRADE.</p><p><strong>Results: </strong>A search identified 469 studies; eleven met the inclusion criteria (four cohort, seven case-control). Six reported a statistically significant association between MHT and increased odds of BOTs; five did not. Combined estrogen-progestin therapy showed a stronger, more consistent positive association (odds ratio 1.426, 95% confidence interval 1.083-1.877), whereas estrogen-only therapy showed a nonsignificant association. Post-diagnosis evidence is extremely limited: no study addressed BOT recurrence, and only one observational study evaluated BOT survival, finding no adverse association.</p><p><strong>Conclusion: </strong>Evidence on the MHT-BOT association is heterogeneous and inconsistent. Although a statistical association was observed between combined MHT and increased odds of BOTs, postsurgical safety data are limited and overall certainty of evidence is very low; findings warrant considerable caution. Current literature is insufficient to confirm or exclude an association between MHT and BOT recurrence or survival. Indications for MHT after BOT surgery require individualized, multidisciplinary discussion involving oncology and menopause specialists, balancing quality-of-life benefits against unquantified theoretical risks.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"669-679"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148204399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual trajectories of allostatic load and depression among perimenopausal women.","authors":"Zhuoran Sun, Haili Huang, Liyan Xie, Yuhong Li","doi":"10.1080/13697137.2026.2661352","DOIUrl":"10.1080/13697137.2026.2661352","url":null,"abstract":"<p><strong>Objective: </strong>Research on allostatic load (AL) and depression has been increasing, but has lacked attention on perimenopausal women. This study aimed to explore the dual trajectories of AL and depression in perimenopausal women and identify their common influencing factors.</p><p><strong>Method: </strong>Data from seven follow-up sites of the Study of Women's Health Across the Nation (SWAN) were used, and 1185 perimenopausal women aged 42-52 years were eventually included. Trajectories of AL and depression were identified by fitting different group-based trajectory models. A dual trajectory model was used to estimate the probability of the correlation between different level trajectory groups of AL and depression, and multivariate logistic regression was used to estimate the degree of association of demographic characteristics of perimenopausal women with AL and depression.</p><p><strong>Results: </strong>In a dual trajectory model of AL and depression, AL and depression showed an interactive association, with high AL trajectories increasing the likelihood of high depression trajectories (14.65%) and high depression trajectories increasing the likelihood of high AL trajectories (41.2%). After considering demographic characteristics, age, race, income level, social support, hot flashes and night sweats were found to be common influences on AL and depression.</p><p><strong>Conclusion: </strong>Interventions should be tailored according to the different trajectory groups of AL and depression, with a focus on high-vulnerability subgroups (high AL without depression, low AL with high depression, high AL with high depression). AL monitoring should also be integrated into perimenopausal depression management. In addition, care should be taken to address the common risk factors behind these trajectories and develop interventions based on relevant determinants.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"720-726"},"PeriodicalIF":3.9,"publicationDate":"2026-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147866997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}