Climacteric最新文献_第3页

Associations between blood sex hormones, cognitive decline and incident dementia in community-dwelling older Australian women: a prospective cohort study. 澳大利亚社区老年妇女血液性激素、认知能力下降和痴呆发生率之间的关系：一项前瞻性队列研究

IF 3.2 4区医学

Climacteric Pub Date : 2025-08-01 Epub Date: 2025-03-14 DOI: 10.1080/13697137.2025.2470458

Farhana Sultana, Susan R Davis, Rory S Wolfe, John J McNeil, Rakibul M Islam

{"title":"Associations between blood sex hormones, cognitive decline and incident dementia in community-dwelling older Australian women: a prospective cohort study.","authors":"Farhana Sultana, Susan R Davis, Rory S Wolfe, John J McNeil, Rakibul M Islam","doi":"10.1080/13697137.2025.2470458","DOIUrl":"10.1080/13697137.2025.2470458","url":null,"abstract":"Objective: Whether blood sex hormone concentrations predict cognitive decline and incident dementia in older women is uncertain. The Sex Hormones in Older Women (SHOW) study is a prospective cohort study of Australian women, aged at least 70 years, without cognitive impairment.Methods: Sex hormones were measured by liquid chromatography-tandem mass spectrometry, and comprehensive cognitive testing was performed at baseline and 3 years later.Results: Of the 6358 participants who had sex hormones measured, 4444 women (median age at baseline 74 years [Q1-Q3 71.7-77.5]) provided data for cognitive analyses. The findings were limited to a decline in executive function and verbal fluency was positively associated with the highest quartiles of estrone (odds ratio [OR] = 1.21, 95% confidence interval [CI] 1.01-1.45, p = 0.04) and dehydro-epiandrosterone (DHEA) (OR = 1.21, 95% CI 1.01-1.45, p = 0.04), compared with the lowest quartiles. Estrone and DHEA were not associated with any other cognitive decline. Testosterone was not associated with cognitive decline. In an exploratory analysis, cognitive decline was not different in women who had estradiol below the limit of detection (66% of women) compared with women with measurable estradiol. Over a median 4.1 years of follow-up (22,518 person-years), 121 (2.2%) developed dementia; an incident rate of 5.3 per 1000 person-years. There were no associations between any hormone and incident dementia.Conclusions: The finding of a greater likelihood of a decline in executive function and verbal fluency in community-dwelling older women with the highest blood concentrations of DHEA and its metabolite estrone need reaffirmation and their clinical significance should be further investigated. These findings do not support use of estrogen or DHEA therapy to prevent cognitive decline in older women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"446-455"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Premature ovarian insufficiency: addressing the most controversial issues. 卵巢功能不全：解决最具争议的问题。

IF 3.2 4区医学

Climacteric Pub Date : 2025-08-01 Epub Date: 2025-05-16 DOI: 10.1080/13697137.2025.2497415

Nick Panay

{"title":"Premature ovarian insufficiency: addressing the most controversial issues.","authors":"Nick Panay","doi":"10.1080/13697137.2025.2497415","DOIUrl":"10.1080/13697137.2025.2497415","url":null,"abstract":"It was a true honor to be invited as President to deliver the Pieter Van Keep oration at the 2024 International Menopause Society (IMS) Congress in Melbourne, Australia. There was never any doubt that the topic of my lecture would be premature ovarian insufficiency (POI). POI is a condition which has been neglected for far too long given its greater global prevalence than originally estimated and its implications to the sufferers, both in terms of quality of life and long-term well-being. The hope is that we are now entering a new era of awareness given the recent update of the European Society of Human Reproduction (ESHRE) POI guideline, achieved through a partnership of the ESHRE, American Society for Reproductive Medicine (ASRM), Centre for Research Excellence in Women's Health in Reproductive Life (CRE WHiRL) at Monash University and IMS with support from numerous global stakeholder organizations. Whilst as a minimum the update of the guideline is expected to improve clinical management of this condition, the process has also identified key areas of much-needed research, where currently only practical guidance can be given due to the lack of data. The aim of my Pieter Van Keep lecture, and therefore this article, was not to replicate the extensive work already conducted to systematically review the literature for the guideline. The aim was to provide a state-of-the-art commentary highlighting the key controversial topics regarding this distressing condition, and how these are being addressed, or should be addressed in the future, for the sake of sufferers and their families.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"377-383"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076341","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Heart matters: the unique landscape of cardiovascular health in women. 心脏问题：女性心血管健康的独特景观。

IF 3.2 4区医学

Climacteric Pub Date : 2025-08-01 Epub Date: 2025-05-16 DOI: 10.1080/13697137.2025.2497419

Gemma A Figtree, Michael P Gray

引用次数: 0

Methodological considerations on insulin resistance and osteoporosis in postmenopausal women. 绝经后妇女胰岛素抵抗与骨质疏松的方法学考虑。

IF 3.2 4区医学

Climacteric Pub Date : 2025-08-01 Epub Date: 2025-07-30 DOI: 10.1080/13697137.2025.2533280

Bengü Mutlu Sütcüoğlu, Elif Yılmaz

引用次数: 0

NK3 receptor antagonist alters the centrally controlled perception of menopausal flushing - a pilot study. NK3受体拮抗剂改变绝经期潮红的中枢控制感知-一项初步研究。

IF 3.2 4区医学

Climacteric Pub Date : 2025-08-01 Epub Date: 2025-03-14 DOI: 10.1080/13697137.2025.2470462

Jenifer Sassarini, Karolina Skorupskaite, John McLean, Mary Ann Lumsden, Richard A Anderson

{"title":"NK3 receptor antagonist alters the centrally controlled perception of menopausal flushing - a pilot study.","authors":"Jenifer Sassarini, Karolina Skorupskaite, John McLean, Mary Ann Lumsden, Richard A Anderson","doi":"10.1080/13697137.2025.2470462","DOIUrl":"10.1080/13697137.2025.2470462","url":null,"abstract":"Objective: Kisspeptin/neurokinin/dynorphin (KNDy) signaling links reproductive and thermoregulatory systems, and improvements in menopausal flushing are reported with neurokinin 3 receptor (NK3R) antagonists. A rise in brainstem activity preceding a flush has been proposed as its functional origin, with subsequent activity in the insula and prefrontal cortices reflecting individual perception. Using functional magnetic resonance imaging (fMRI), this study investigated the central effect of the NK3R antagonist MLE4901 during a flush, particularly functional connectivity changes in the salience network.Method: Five postmenopausal women with flushes completed a 1-week flush diary prior to baseline fMRI, during which hot flushes were triggered by heating. Diaries were continued during 7 days of treatment with the NK3R antagonist MLE4901, with repeat fMRI on day 7. Sternal monitors recorded objective flushing before each fMRI. Connectivity changes in the salience network post flush were assessed.Results: Treatment with MLE4901 reduced the subjective flush frequency (from median 6.9 to 1.1 per day; p = 0.02) without changes in objective flushes. Treatment decreased right anterior insula connectivity, which correlated significantly with decreased subjective flushing.Conclusion: This pilot study demonstrates decreased connectivity in the salience network during NK3R antagonist treatment. This may indicate areas of interest for further targeted fMRI studies and mechanistic investigation of this novel treatment for flushing.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"438-445"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Practices and challenges in the management of the menopause in the Asia-Pacific Menopause Federation. 亚太更年期联合会管理更年期的实践与挑战。

IF 3.2 4区医学

Climacteric Pub Date : 2025-08-01 Epub Date: 2025-06-23 DOI: 10.1080/13697137.2025.2514030

Seng Bin Ang, Felicia Clara Jun Hui Tan, Stella Rizalina Sasha Sugianto, Sonia Davison, Qi Yu, Masakazu Terauchi, Mee-Ran Kim, Jignesh Shah, S K Zinnat Ara Nasreen, Choon Moy Ho, Enkhee Sodnomdorj, M Fidel Ganis Siregar, Rubina Hussain, Ma Corazon Zaida N Gamilla, Yang Chua, Yung-Chieh Tsai, Unnop Jaisamrarn

{"title":"Practices and challenges in the management of the menopause in the Asia-Pacific Menopause Federation.","authors":"Seng Bin Ang, Felicia Clara Jun Hui Tan, Stella Rizalina Sasha Sugianto, Sonia Davison, Qi Yu, Masakazu Terauchi, Mee-Ran Kim, Jignesh Shah, S K Zinnat Ara Nasreen, Choon Moy Ho, Enkhee Sodnomdorj, M Fidel Ganis Siregar, Rubina Hussain, Ma Corazon Zaida N Gamilla, Yang Chua, Yung-Chieh Tsai, Unnop Jaisamrarn","doi":"10.1080/13697137.2025.2514030","DOIUrl":"10.1080/13697137.2025.2514030","url":null,"abstract":"Objectives: The experiences and needs of women undergoing the menopausal transition vary widely amongst countries in the Asia-Pacific. Thus, practices and challenges amongst clinicians treating perimenopausal and menopausal women in the Asia-Pacific also vary. This study aims to characterize the diverse practices and challenges in managing the menopause across the Asia-Pacific.Methods: Clinicians in the member organizations of the Asia-Pacific Menopause Federation were invited to participate in a questionnaire seeking information on their usual practices and the challenges faced in managing the menopause.Results: A total of 39 clinicians from 14 countries in the Asia-Pacific Menopause Federation responded to the questionnaire. While there were similar practices in assessment, clinicians' preferences in prescribing menopausal hormonal therapy varied widely. Challenges they faced included cultural and literacy barriers amongst their patients, a lack of support for menopause care in their healthcare systems and limited availability of novel therapies.Conclusion: Practices in managing the menopause vary across the Asia-Pacific. Further research and governmental support are needed to establish consensus on managing the menopause and supporting midlife women's health issues in the Asia-Pacific.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"431-437"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144474110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Medical management of obesity: unlocking the potential. 肥胖的医疗管理：释放潜力。

IF 3.2 4区医学

Climacteric Pub Date : 2025-08-01 Epub Date: 2025-02-07 DOI: 10.1080/13697137.2025.2455177

Angie S Xiang, Priya Sumithran

引用次数: 0

Explanations of the study on insulin resistance and osteoporosis in postmenopausal women. 绝经后妇女胰岛素抵抗与骨质疏松研究的解释。

IF 3.2 4区医学

Climacteric Pub Date : 2025-08-01 Epub Date: 2025-07-28 DOI: 10.1080/13697137.2025.2533281

Min Li, Lei Gao, Ying Liu, Yongli Zheng, Luyao Chen, Yan Wang, Wei Zhang

引用次数: 0

IMS World Congress on Menopause. 世界更年期大会。

IF 3.2 4区医学

Climacteric Pub Date : 2025-08-01 Epub Date: 2025-08-22 DOI: 10.1080/13697137.2025.2523718

Rod Baber

引用次数: 0

Laser for genitourinary syndrome of menopause: what we know and what we need to know. 激光治疗更年期泌尿生殖系统综合症：我们知道什么，我们需要知道什么。

IF 3.2 4区医学

Climacteric Pub Date : 2025-08-01 Epub Date: 2025-02-19 DOI: 10.1080/13697137.2025.2455186

Fiona G Li, Jason Abbott

{"title":"Laser for genitourinary syndrome of menopause: what we know and what we need to know.","authors":"Fiona G Li, Jason Abbott","doi":"10.1080/13697137.2025.2455186","DOIUrl":"10.1080/13697137.2025.2455186","url":null,"abstract":"Energy-based treatments, including the fractional CO2 laser, have been widely used for treatment of genitourinary symptoms associated with menopause. With the availability of data from seven double-blind sham-controlled randomized trials, the evidence does not support the fractional CO2 laser as an efficacious treatment for genitourinary syndrome of menopause (GSM). A 2024 meta-analysis of these trials demonstrated that the symptom with greatest absolute improvement was dyspareunia at 16.3%, although not statistically significant. This improvement is far less than previously anticipated based on prospective data that suggested promising improvements of more than 90% satisfaction following laser treatment. Other data, including those from unblinded studies which are subject to a placebo effect, and outcomes that are not participant-reported including the appearance of the vagina on examination and histology, are not reliable in determining efficacy of laser treatment for GSM. While there may be a clinical effect of laser over sham treatments for GSM, the effect is unlikely to be clinically meaningful. Until we define and demonstrate a minimal clinically important difference in a robust and appropriately powered study, the laser should not be used in a clinical context for GSM.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"414-422"},"PeriodicalIF":3.2,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0