Effects of a therapeutic lifestyle modification intervention on health-related quality of life and sexual functioning and cardiometabolic health in perimenopausal Chinese women: a randomized controlled trial.

IF 2.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY

Climacteric Pub Date : 2024-12-13 DOI:10.1080/13697137.2024.2435879

Yuru Wang, Xiaoling Miao, Pramon Viwattanakulvanid

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引用次数: 0

Abstract

Objective: This study aimed to evaluate the effects of a therapeutic lifestyle modification (TLM) intervention on health-related quality of life, sexual functioning and cardiometabolic health in perimenopausal Chinese women.

Method: The study was a randomized controlled trial (registration number: ChiCTR2300070648). Ninety-four perimenopausal women aged between 40 and 55 years were randomly assigned in a 1:1 ratio to receive the TLM intervention or usual care for 12 weeks. Menopause-specific Quality of Life (MENQOL), Female Sexual Function Index (FSFI), pelvic floor muscle strength (PFMS) and composite cardiometabolic indicators were evaluated at baseline and post intervention.

Results: After 12 weeks, linear mixed-effects models showed that the TLM intervention led to a statistically significant improvement in MENQOL (-0.60, 95% confidence interval [CI] - 0.80 to -0.41), FSFI (3.82, 95% CI 2.03 to 5.61), resting heart rate (-5.44, 95% CI -10.40 to -0.48), waist circumference(-3.14, 95% CI -4.15 to -2.13) and body fat percentage (-4.25, 95% CI -6.92 to -1.58) compared to the control group. There were also statistically significant differences between the intervention (TLM) group and the control group in the proportions of PFMS (p = 0.006).

Conclusion: The TLM intervention effectively improved menopause-specific quality of life in midlife women, supported by enhancements in female sexual functioning and cardiometabolic health status.

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研究目的本研究旨在评估治疗性生活方式改变（TLM）干预对围绝经期中国女性健康相关生活质量、性功能和心脏代谢健康的影响：本研究为随机对照试验（注册号：ChiCTR2300070648）。94名年龄在40至55岁之间的围绝经期妇女按1:1的比例被随机分配到接受TLM干预或常规护理，为期12周。在基线和干预后对绝经期生活质量（MENQOL）、女性性功能指数（FSFI）、盆底肌力（PFMS）和综合心脏代谢指标进行评估：结果：12 周后，线性混合效应模型显示，TLM 干预对 MENQOL（-0.60，95% 置信区间 [CI] - 0.80 至 -0.41）、FSFI（3.82, 95% CI 2.03 to 5.61）、静息心率（-5.44, 95% CI -10.40 to -0.48）、腰围（-3.14, 95% CI -4.15 to -2.13）和体脂百分比（-4.25, 95% CI -6.92 to -1.58）与对照组相比均有统计学意义的改善。干预组（TLM）与对照组在 PFMS 的比例上也有显著的统计学差异（P = 0.006）：TLM干预有效改善了中年女性更年期特有的生活质量，并提高了女性的性功能和心脏代谢健康状况。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.