更年期可能与端粒长度有关吗？综合审查结果。

IF 2.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY

Climacteric Pub Date : 2024-07-18 DOI:10.1080/13697137.2024.2376193

M M S Bem, C M S Paraizo-Horvath, P S Freitas, T R P Brito

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引用次数: 0

摘要

研究目的鉴于更年期对女性健康的重要影响，以及通过基于衰老生物标志物的研究可以更好地了解女性的长寿，对更年期与端粒缩短之间关系的研究可能有助于更好地了解这一生命阶段。本研究旨在分析有关更年期与端粒长度之间关系的研究成果：这项综合性文献综述包括在PubMed、CINAHL、LILACS、Web of Science和Scopus数据库中进行检索。结果：这些研究结果表明，老年女性的雌激素水平较高，而雌激素水平较低的女性的雌激素水平较低：这些研究结果表明，绝经年龄越大、生育期越长（绝经年龄与月经初潮年龄之差）与端粒越长，即与长寿有关：结论：绝经与端粒长度之间的关系尚不确定。本综述中包含的研究数量较少，而且研究结果表明更年期与端粒长度之间的关系可能取决于更年期的阶段和种族/民族，这表明应针对这些变量开展更多的研究。

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Is it possible that menopause is associated with telomere length? Findings of an integrative review.

Objective: Knowing the important repercussions of menopause for women's health and that female longevity can be better understood through studies based on aging biomarkers, studies on the relationship between menopause and telomere shortening may help to better understand this stage of life. This study aimed to analyze what research has been produced regarding the relationship between menopause and telomere length.

Methods: This integrative literature review included searches in PubMed, CINAHL, LILACS, Web of Science and Scopus databases. Four studies were selected for the final sample.

Results: The findings of these studies indicate that older age for menopause and longer reproductive life (difference between age at menopause and menarche) are associated with longer telomeres, that is, with longevity.

Conclusion: The relationship between menopause and telomere length is uncertain. The small number of studies included in this review, and the fact that the results indicate that the relationship between menopause and telomere length may be dependent on the stage of the menopause and race/ethnicity, suggest that additional research focusing on these variables should be carried out.

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.