Climacteric最新文献_第9页

Associations between menopausal symptoms and cardiovascular disease in middle-aged Chinese women. 中国中年女性更年期症状与心血管疾病之间的关系。

IF 2.9 4区医学

Climacteric Pub Date : 2024-08-01 Epub Date: 2024-07-04 DOI: 10.1080/13697137.2024.2368479

Xueyin Wang, Juan Juan, Di Gao, Bo Song, Xiaosong Zhang

{"title":"Associations between menopausal symptoms and cardiovascular disease in middle-aged Chinese women.","authors":"Xueyin Wang, Juan Juan, Di Gao, Bo Song, Xiaosong Zhang","doi":"10.1080/13697137.2024.2368479","DOIUrl":"10.1080/13697137.2024.2368479","url":null,"abstract":"Objective: This study aimed to examine the association between severity of menopausal symptoms and cardiovascular disease (CVD) risk among middle-aged Chinese women.Methods: A cross-sectional study recruited 9679 women aged 40-70 years from three socioeconomic regions of China in 2018. Menopausal symptoms were assessed by the modified Kupperman Menopausal Index (KMI). The severity of individual symptoms was classified as none (0 points), mild (1 points) and moderate-to-severe symptoms (2-3 points), and overall menopausal symptoms were classified as none (<15 points), mild (15-24 points) or moderate-to-severe (≥25 points) according to the sum score of the KMI. Logistic regression models were used to examine associations of the severity of menopausal symptoms with CVD risk.Results: A total of 5.6% of participants reported being diagnosed with CVD. Overall menopausal symptoms were more common in women aged 60-70 years than in women aged 40-59 years. After multiple adjustment, mild (odds ratio [OR] = 2.07, 95% confidence interval [CI]: 1.64-2.61) and moderate-to-severe (OR = 2.64, 95% CI: 1.92-3.63) overall menopausal symptoms were associated with increased risk of CVD compared with no symptoms. Significant positive associations between the severity of individual menopausal symptoms and CVD risk were observed for all 13 items.Conclusion: The severity of menopausal symptoms was positively associated with CVD risk in middle-aged Chinese women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"413-420"},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141533767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Fezolinetant for VMS: a balanced view on efficacy and safety needed. 治疗 VMS 的非唑烷内酯：需要平衡疗效和安全性。

IF 2.9 4区医学

Climacteric Pub Date : 2024-08-01 Epub Date: 2024-07-09 DOI: 10.1080/13697137.2024.2370873

Jonathan Douxfils, Charlotte Beaudart, Jean-Michel Dogné

引用次数: 0

Vaginal dryness: a review of current understanding and management strategies. 阴道干涩：当前认识和管理策略综述。

IF 2.9 4区医学

Climacteric Pub Date : 2024-06-01 Epub Date: 2024-02-06 DOI: 10.1080/13697137.2024.2306892

J K K Mark, S Samsudin, I Looi, K H Yuen

引用次数: 0

Allelic variants of the estrogen receptor genes and frailty phenotype in postmenopausal women. 雌激素受体基因的等位基因变异与绝经后妇女的虚弱表型。

IF 2.9 4区医学

Climacteric Pub Date : 2024-06-01 Epub Date: 2024-02-06 DOI: 10.1080/13697137.2024.2306269

A Monllor-Tormos, A García-Vigara, O Morgan, M-Á García-Pérez, J J Tarín, A Cano

{"title":"Allelic variants of the estrogen receptor genes and frailty phenotype in postmenopausal women.","authors":"A Monllor-Tormos, A García-Vigara, O Morgan, M-Á García-Pérez, J J Tarín, A Cano","doi":"10.1080/13697137.2024.2306269","DOIUrl":"10.1080/13697137.2024.2306269","url":null,"abstract":"Objective: The prevalence of frailty has been related to menopause. Our main objective was to investigate whether single nucleotide polymorphisms (SNPs) of the estrogen receptor (ER) ER<math><mi>α</mi></math> and ER<math><mrow><mi>β</mi></mrow></math> genes were related to the frailty phenotype in a population of community-dwelling postmenopausal women.Methods: A cross-sectional study was performed in which we selected five SNPs, three in the ER<math><mrow><mi>α</mi></mrow></math> gene and two in the ER<math><mrow><mi>β</mi></mrow></math>. Linear regression was used to estimate the percentage of phenotypic variance after adjusting for confounding variables.Results: A total of 470 women (mean ± standard deviation age 63.83 ± 8.16 years) were included, of whom 137 women were frail. The SNP rs3798577 of the ER<math><mrow><mi>α</mi></mrow></math> gene was the only variant associated with frailty, but this significance faded in the multivariant analysis. Body mass index (p = 0.012), number of comorbidities (0 vs. ≥2, p = 0.002) and two reproductive variables, number of miscarriages (none vs. ≥2, p = 0.036) and of childbirths (one vs. ≥3, p = 0.008), were independently related to frailty.Conclusion: The five SNPs of the ER<math><mrow><mi>α</mi></mrow></math> and ER<math><mrow><mi>β</mi></mrow></math> genes tested were not correlated with frailty. Other SNPs of the ER warrant analysis to clarify whether variance in the gene response affects frailty status.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"314-320"},"PeriodicalIF":2.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139691361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An ethical assessment of compounded bioidentical hormone therapy. 复方生物相同激素疗法的伦理评估。

IF 2.8 4区医学

Climacteric Pub Date : 2024-06-01 Epub Date: 2024-01-30 DOI: 10.1080/13697137.2024.2306272

R P Kauffman, E J MacLaughlin, L A Courtney, D D Vineyard

引用次数: 0

Higher testosterone is associated with higher HDL-cholesterol and lower triglyceride concentrations in older women: an observational study. 老年妇女体内较高的睾酮与较高的高密度脂蛋白胆固醇和较低的甘油三酯浓度有关：一项观察性研究。

IF 2.9 4区医学

Climacteric Pub Date : 2024-06-01 Epub Date: 2024-02-12 DOI: 10.1080/13697137.2024.2310530

S R Davis, Z N Azene, A M Tonkin, R L Woods, J J McNeil, R M Islam

{"title":"Higher testosterone is associated with higher HDL-cholesterol and lower triglyceride concentrations in older women: an observational study.","authors":"S R Davis, Z N Azene, A M Tonkin, R L Woods, J J McNeil, R M Islam","doi":"10.1080/13697137.2024.2310530","DOIUrl":"10.1080/13697137.2024.2310530","url":null,"abstract":"Objective: This study aimed to determine whether concentrations of testosterone and its main precursor after menopause, dehydroepiandrosterone (DHEA), are associated with lipoproteins and other lipids in community-dwelling older women.Methods: The Sex Hormones in Older Women (SHOW) study was an observational study of 6358 Australian women, aged at least 70 years, with no prior major adverse cardiovascular event who had sex hormones measured by liquid chromatography-tandem mass spectrometry. Associations between hormones and lipids were examined using multilinear regression adjusted for potential confounders.Results: The cross-sectional analyses included 3231 participants, median age 74.0 (interquartile range 71.7-77.9) years. Compared with concentrations in the lowest quartile (Q1), testosterone concentrations in the highest quartiles (Q3 and Q4) were positively associated with high-density lipoprotein cholesterol (HDL-C) (p = 0.002 and p < 0.001, respectively) while Q4 testosterone concentrations were positively associated with total cholesterol (p = 0.038). Q2, Q3 and Q4 testosterone concentrations were significantly inversely associated with triglycerides (TG) (p = 0.024, p = 0.003 and p < 0.001, respectively). For DHEA, Q4 concentrations was positively associated with non-HDL-C (p = 0.024).Conclusions: In older women, higher endogenous testosterone concentrations are significantly associated with higher HDL-C and lower TG, indicating a less atherogenic profile. These findings suggest a neutral, or potentially protective, cardiovascular disease effect of testosterone in older women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"282-288"},"PeriodicalIF":2.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11196127/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139721847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 更正。

IF 2.8 4区医学

Climacteric Pub Date : 2024-06-01 Epub Date: 2024-03-14 DOI: 10.1080/13697137.2024.2327254

引用次数: 0

Self-management eHealth solutions for menopause - a systematic scoping review. 更年期自我管理电子健康解决方案--系统性范围界定审查。

IF 2.9 4区医学

Climacteric Pub Date : 2024-06-01 Epub Date: 2024-04-29 DOI: 10.1080/13697137.2024.2334035

Sabrina Vollrath, Susanne Theis, Argyrios Kolokythas, Heidrun Janka, Sarah Schleich, Jens Moreth, Ludwig Kiesel, Petra Stute

{"title":"Self-management eHealth solutions for menopause - a systematic scoping review.","authors":"Sabrina Vollrath, Susanne Theis, Argyrios Kolokythas, Heidrun Janka, Sarah Schleich, Jens Moreth, Ludwig Kiesel, Petra Stute","doi":"10.1080/13697137.2024.2334035","DOIUrl":"10.1080/13697137.2024.2334035","url":null,"abstract":"Objective: The purpose of this scoping review was to highlight the current scientific evidence on eHealth-based information tools for menopause in terms of quality, requirements and previous intervention outcomes.Methods: We systematically searched electronic databases (Embase, CINAHL, Cochrane Library, Global Health Database [Ovid], Web of Science, ClinicalTrials.gov [NLM], LIVIVO Search Portal [ZB MED] and Google Scholar) from 1974 to March 2022 for relevant records.Results: Our search yielded 1773 records, of which 28 met our inclusion criteria. Thirteen of 28 selected studies were cross-sectional with qualitative content analysis of websites about menopause; 9 studies were cohort studies examining the impact of an eHealth intervention; two studies were randomized controlled trials comparing eHealth tools with conventional ones; and four studies were non-systematic literature reviews.Conclusion: This scoping review highlights the potential of eHealth-based information tools for the management of menopause and shows that most eHealth-based information tools are inadequate in terms of readability and the balanced view on information. Providers of eHealth-based information tools should pay attention to a participatory design, readability, balance of content and the use of multimedia tools for information delivery to improve understanding.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"255-268"},"PeriodicalIF":2.9,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140848003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The rs2018736 fibulin-5 polymorphism as a determinant for pelvic organ prolapse: a case-control study. 作为盆腔器官脱垂决定因素的 rs2018736 纤维素-5 多态性：一项病例对照研究。

IF 2.8 4区医学

Climacteric Pub Date : 2024-06-01 Epub Date: 2024-03-27 DOI: 10.1080/13697137.2024.2327988

Juliana B Teixeira, Maria A T Bortolini, Rebecca S P Silva, Nilce C Batista, Carolina L Costa E Silva, Kristina Allen-Brady, Rodrigo A Castro

{"title":"The rs2018736 fibulin-5 polymorphism as a determinant for pelvic organ prolapse: a case-control study.","authors":"Juliana B Teixeira, Maria A T Bortolini, Rebecca S P Silva, Nilce C Batista, Carolina L Costa E Silva, Kristina Allen-Brady, Rodrigo A Castro","doi":"10.1080/13697137.2024.2327988","DOIUrl":"10.1080/13697137.2024.2327988","url":null,"abstract":"Objective: Fibulin-5 is a connective tissue component and may play a role in pelvic organ prolapse (POP) pathogenesis. This study aimed to verify the association of the rs2018736 polymorphism of the fibulin-5 gene with POP in postmenopausal Brazilian women, and to determine the risk factors for POP.Method: This observational, cross-sectional, case-control study assessed postmenopausal women with advanced POP (stages III and IV) and control women (stages 0 and I) by examination and peripheral blood sample collection. DNA sequences were analyzed by real-time reverse-transcriptase polymerase chain reaction. A logistic regression model was used with p < 0.05 for significance.Results: A total of 565 participants were evaluated (325 POP and 240 control). The homozygous C allele of rs2018736 (CC) was protective against POP (odds ratio [OR] 0.49, 95% confidence interval [CI] 0.26-0.91). Age (OR 1.09, 95% CI 1.05-1.13), number of pregnancies (OR 1.14, 95% CI 1.01-1.28), vaginal delivery (OR 5.32, 95% CI 2.58-11.01), forceps delivery (OR 3.34, 95% CI 1.72-6.47), weight of newborn (OR 1.0007, 95% CI 1.0002-1.0011), family history of POP (OR 2.35, 95% CI 1.24-4.44), hypertension (OR 1.74, 95% CI 1.01-3.00) and diabetes (OR 2.19, 95% CI 1.07-4.48)] were independent predictors for POP; cesarean (OR 0.02, 95% CI 0.005-0.09) was protective.Conclusion: The rs2018736-CC genotype of the fibulin-5 gene has a protective role against POP.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"321-325"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140292989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The LADY study: epidemiological characteristics of prevalent and new genitourinary syndrome of menopause cases in Greece. LADY 研究：希腊更年期生殖泌尿系统综合征流行病学特征。

IF 2.8 4区医学

Climacteric Pub Date : 2024-06-01 Epub Date: 2024-02-28 DOI: 10.1080/13697137.2024.2314504

I Lambrinoudaki, N Mili, A Augoulea, E Armeni, N Vlahos, T Mikos, G Grimbizis, A Rodolakis, S Athanasiou

{"title":"The LADY study: epidemiological characteristics of prevalent and new genitourinary syndrome of menopause cases in Greece.","authors":"I Lambrinoudaki, N Mili, A Augoulea, E Armeni, N Vlahos, T Mikos, G Grimbizis, A Rodolakis, S Athanasiou","doi":"10.1080/13697137.2024.2314504","DOIUrl":"10.1080/13697137.2024.2314504","url":null,"abstract":"Objective: The genitourinary syndrome of menopause (GSM) is often underdiagnosed and undertreated despite its significant impact on postmenopausal quality of life. We assessed the prevalence of GSM and associated symptoms in Greek perimenopausal/postmenopausal women attending gynecology clinics.Methods: Four hundred and fifty women, aged 40-70 years (93.1% postmenopausal), attending three gynecology clinics at university hospitals completed a validated questionnaire and underwent pelvic examination.Results: GSM was diagnosed in 87.6% of the women at the study visit, whereas only 16% of the overall sample had been previously diagnosed with the condition. Vaginal dryness (72.7%), vulvar burning sensation or itching (58.0%) and dyspareunia (52.7%) were the most prevalent symptoms. Pelvic signs consisted of vaginal dryness (89.1%), loss of vaginal rugae (80.6%) and vulvovaginal pallor (86.9%). However, only 31.3% of the participants had discussed genitourinary symptoms with their health-care professionals (HCPs). Regarding management, only 11.1% of women had prior experience with any form of therapy, and currently only 8.7% were receiving treatment.Conclusion: GSM is highly prevalent in this Greek perimenopausal/postmenopausal population. Nevertheless, the majority of women remain undiagnosed and untreated. Education for both women and HCPs regarding GSM will lead to improved diagnosis and better management of this syndrome.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"289-295"},"PeriodicalIF":2.8,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139982505","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0