Climacteric最新文献_第9页

A disease of her own? Unique features of heart failure in women. 她自己的病？女性心力衰竭的独特特征。

IF 2.8 4区医学

Climacteric Pub Date : 2024-02-01 Epub Date: 2024-01-15 DOI: 10.1080/13697137.2023.2256673

W A Spacht, E S Lau

引用次数: 0

Menopausal hormone therapy and coronary heart disease: the roller-coaster history. 更年期激素疗法与冠心病：过山车般的历史。

IF 2.8 4区医学

Climacteric Pub Date : 2024-02-01 Epub Date: 2024-01-15 DOI: 10.1080/13697137.2023.2282690

M Nudy, J Buerger, S Dreibelbis, X Jiang, H N Hodis, P F Schnatz

{"title":"Menopausal hormone therapy and coronary heart disease: the roller-coaster history.","authors":"M Nudy, J Buerger, S Dreibelbis, X Jiang, H N Hodis, P F Schnatz","doi":"10.1080/13697137.2023.2282690","DOIUrl":"10.1080/13697137.2023.2282690","url":null,"abstract":"In the USA it is estimated that more than one million women become menopausal each year. Coronary heart disease (CHD) is the leading cause of mortality in menopausal woman globally. The majority of perimenopausal to postmenopausal women experience bothersome symptoms including hot flashes, night sweats, mood liability, sleep disturbances, irregular bleeding and sexual dysfunction. While menopausal hormone therapy (HT) effectively treats most of these symptoms, use of HT has become confusing, especially related to CHD risk. Despite years of observational and retrospective studies supporting a CHD benefit and improved survival among HT users, the Heart and Estrogen/Progestin Replacement Study (HERS) and the Women's Health Initiative (WHI) raised doubts about this long-held premise. The timing hypothesis has since emerged and states that when HT is initiated in younger women, soon after menopause onset, there may be cardiovascular benefit. The following review discusses the roller-coaster history of HT use as it pertains to CHD in postmenopausal women. Studies that highlight HT's CHD benefit are reviewed and provide reassurance that HT utilized in appropriately selected younger postmenopausal women close to the onset of menopause is safe from a cardiovascular perspective, in line with consensus recommendations.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"81-88"},"PeriodicalIF":2.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138486844","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Good night and good luck. 晚安，祝你好运。

IF 2.8 4区医学

Climacteric Pub Date : 2024-02-01 Epub Date: 2024-01-15 DOI: 10.1080/13697137.2023.2287312

Rod Baber

引用次数: 0

Understanding of and clinical approach to cardiometabolic transition at the menopause. 对更年期心脏代谢转变的理解和临床方法。

IF 2.8 4区医学

Climacteric Pub Date : 2024-02-01 Epub Date: 2023-05-24 DOI: 10.1080/13697137.2023.2202809

I Lambrinoudaki, E Armeni

{"title":"Understanding of and clinical approach to cardiometabolic transition at the menopause.","authors":"I Lambrinoudaki, E Armeni","doi":"10.1080/13697137.2023.2202809","DOIUrl":"10.1080/13697137.2023.2202809","url":null,"abstract":"Cardiovascular disease (CVD) represents the leading cause of death and accounts for almost 50% of all deaths in women worldwide. The menopausal transition is associated with central body fat accumulation, a decrease in energy expenditure, weight gain, insulin resistance and a pro-atherogenic lipid profile. Moreover, menopause is independently associated with an adverse effect on functional and structural indices of subclinical atherosclerosis. Women with premature ovarian insufficiency have heightened CVD risk compared to women of natural age at menopause. Furthermore, women with severe menopausal symptoms may have a more adverse cardiometabolic profile than those without symptoms. We reviewed the latest evidence on the cardiovascular management of perimenopausal or postmenopausal women. Clinicians should aim for cardiovascular risk stratification, followed by dietary and lifestyle advice as required based on individual needs. The medical management of cardiometabolic risk factors at midlife should always be individualized, focusing on hypertension, diabetes and dyslipidemia. Menopausal hormone therapy, when prescribed for the management of bothersome menopausal symptoms or for the prevention of osteoporosis, has also a beneficial effect on cardiometabolic risk factors. This narrative review aims to summarize the cardiometabolic alternations occurring during the menopausal transition and to outline the appropriate prevention strategies to prevent future cardiovascular adverse outcomes.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"68-74"},"PeriodicalIF":2.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9522514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Primary prevention of cardiovascular disease in women. 女性心血管疾病的初级预防。

IF 2.8 4区医学

Climacteric Pub Date : 2024-02-01 Epub Date: 2024-01-15 DOI: 10.1080/13697137.2023.2282685

M P Gray, B Vogel, R Mehran, J A Leopold, G A Figtree

{"title":"Primary prevention of cardiovascular disease in women.","authors":"M P Gray, B Vogel, R Mehran, J A Leopold, G A Figtree","doi":"10.1080/13697137.2023.2282685","DOIUrl":"10.1080/13697137.2023.2282685","url":null,"abstract":"Ischemic heart disease is the primary cause of cardiovascular disease (CVD) mortality in both men and women. Strategies targeting traditional modifiable risk factors are essential - including hypertension, smoking, dyslipidemia and diabetes mellitus - particularly for atherosclerosis, but additionally for stroke, heart failure and some arrhythmias. However, challenges related to education, screening and equitable access to effective preventative therapies persist, and are particularly problematic for women around the globe and those from lower socioeconomic groups. The association of female-specific risk factors (e.g. premature menopause, gestational hypertension, small for gestational age births) with CVD provides a potential window for targeted prevention strategies. However, further evidence for specific effective screening and interventions is urgently required. In addition to population-level factors involved in increasing the risk of suffering a CVD event, efforts are leveraging the enormous potential of blood-based 'omics', improved imaging biomarkers and increasingly complex bioinformatic analytic approaches to strive toward more personalized early disease detection and personalized preventative therapies. These novel tactics may be particularly relevant for women in whom traditional risk factors perform poorly. Here we discuss established and emerging approaches for improving risk assessment, early disease detection and effective preventative strategies to reduce the mammoth burden of CVD in women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"104-112"},"PeriodicalIF":2.8,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139402108","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estrogen as a guardian of auditory health: Tsp1-CD47 axis regulation and noise-induced hearing loss. 雌激素是听觉健康的守护者：Tsp1-CD47轴调节与噪音诱发的听力损失

IF 2.8 4区医学

Climacteric Pub Date : 2023-12-18 DOI: 10.1080/13697137.2023.2287632

X Wang, H Zheng, B Yang, M Zu, Z Wang, J Zhang, F Zheng, M Yang, M C F Tong, L Zhao, W Bai

{"title":"Estrogen as a guardian of auditory health: Tsp1-CD47 axis regulation and noise-induced hearing loss.","authors":"X Wang, H Zheng, B Yang, M Zu, Z Wang, J Zhang, F Zheng, M Yang, M C F Tong, L Zhao, W Bai","doi":"10.1080/13697137.2023.2287632","DOIUrl":"10.1080/13697137.2023.2287632","url":null,"abstract":"Objectives: This study aimed to analyze the role of estrogen in noise-induced hearing loss (NIHL) and uncover underlying mechanisms.Methods: An ovariectomized Sprague-Dawley rat model (OVX) was constructed to investigate the hearing threshold and auditory latency before and after noise exposure using the auditory brainstem response (ABR) test. The morphological changes were assessed using immunofluorescence, scanning electron microscopy and transmission electron microscopy. Proteomics and bioinformatics were used to analyze the mechanism. The findings were further verified through western blot and Luminex liquid suspension chip technology.Results: After noise exposure, OVX rats exhibited substantially elevated hearing thresholds. A conspicuous delay in ABR wave I latency was observed, alongside increased loss of outer hair cells, severe collapse of stereocilia and pronounced deformation of the epidermal plate. Accordingly, OVX rats with estrogen supplementation exhibited tolerance to NIHL. Additionally, a remarkable upregulation of the thrombospondin 1 (Tsp1)-CD47 axis in OVX rats was discovered and verified.Conclusions: OVX rats were more susceptible to NIHL, and the protective effect of estrogen was achieved through regulation of the Tsp1-CD47 axis. This study presents a novel mechanism through which estrogen regulates NIHL and offers a potential intervention strategy for the clinical treatment of NIHL.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-11"},"PeriodicalIF":2.8,"publicationDate":"2023-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138799369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polycystic ovary syndrome: associations with cardiovascular disease 多囊卵巢综合征：与心血管疾病的关系

IF 2.8 4区医学

Climacteric Pub Date : 2023-12-11 DOI: 10.1080/13697137.2023.2282689

J. L. Benham, A. Goldberg, H. Teede, C. T. Tay

引用次数: 0

Impact of the new coronavirus (SARS-CoV-2) pandemic on climacteric women's health: Websurvey. 新型冠状病毒(SARS-CoV-2)大流行对更年期妇女健康的影响:网络调查。

IF 2.8 4区医学

Climacteric Pub Date : 2023-12-01 Epub Date: 2023-09-05 DOI: 10.1080/13697137.2023.2246877

L G Pezzali, F V Ferreira, F V Ferreira, M C O Wender

{"title":"Impact of the new coronavirus (SARS-CoV-2) pandemic on climacteric women's health: Websurvey.","authors":"L G Pezzali, F V Ferreira, F V Ferreira, M C O Wender","doi":"10.1080/13697137.2023.2246877","DOIUrl":"10.1080/13697137.2023.2246877","url":null,"abstract":"Objective: The menopausal transition is an important milestone in female reproductive life. Many studies have been conducted to assess the impact of the COVID-19 pandemic on women, but few of them focus on the climacteric population. This study aimed to investigate changes in the health and health care of climacteric women aged 40-70 years residing in Brazil during the pandemic period.Method: A cross-sectional study was carried out using an electronic form with questions related to sociodemographic, clinical and gynecological data, treatments, access to health services and changes in behavior.Results: A total of 419 women answered the questionnaire. Sixty percent reported weight gain and 50.8% reported reduced physical activity practice. More than 80% reported worsening mental health and 66.1% had a change in their sleep pattern. More than half reported having difficulty accessing gynecological consultations and routine examinations. Women living in capital cities reported a greater change in alcohol consumption (p = 0.002). Income change was associated with a higher prevalence of weight gain (p = 0.033) and changes in sleep quality (p = 0.018).Conclusion: We observed an important reduction in the health care of climacteric women during the pandemic period, such as a decrease in medical consultations and preventive examinations, worsening of life habits and deterioration in mental health.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"594-600"},"PeriodicalIF":2.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10159188","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

VDR gene ApaI polymorphism and risk of postmenopausal osteoporosis: a meta-analysis from 22 studies. VDR基因ApaI多态性与绝经后骨质疏松风险:来自22项研究的荟萃分析

IF 2.8 4区医学

Climacteric Pub Date : 2023-12-01 Epub Date: 2023-07-21 DOI: 10.1080/13697137.2023.2233421

B Wang, H Li, C Yang, R Nie, X Zhang, C Pu

{"title":"VDR gene ApaI polymorphism and risk of postmenopausal osteoporosis: a meta-analysis from 22 studies.","authors":"B Wang, H Li, C Yang, R Nie, X Zhang, C Pu","doi":"10.1080/13697137.2023.2233421","DOIUrl":"10.1080/13697137.2023.2233421","url":null,"abstract":"Objective: The ApaI polymorphism (G > T, rs7975232) of the vitamin D receptor (VDR) gene in the risk of postmenopausal osteoporosis has been widely researched, and the results have yielded conflicts. Therefore, we performed an updated pooled analysis to comprehensively assess the association between VDR ApaI polymorphism and postmenopausal osteoporosis risk.Methods: We searched eligible studies about ApaI polymorphism and osteoporosis through the PubMed, Embase, CNKI and Wanfang databases; case-control studies containing available genotype frequencies of A/a were chosen. We used the odds ratio with 95% confidence interval to assess the strength of this association. Sensitivity analysis and publication bias assessment were performed. Trial sequential analysis (TSA) was performed to evaluate a sufficient sample.Results: Twenty-two studies assessed the relationship between ApaI polymorphism and the risk of osteoporosis in postmenopausal women. The comprehensive analyses showed no significant association for ApaI polymorphism with postmenopausal osteoporosis in the overall population, equally valid for Asian and Caucasian subgroups with any genetic model. TSA still indicated the results were robust.Conclusion: The present meta-analysis suggests that the VDR ApaI genotype may not affect the risk of postmenopausal osteoporosis in Asians and Caucasians.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"583-593"},"PeriodicalIF":2.8,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9850833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Professor Linda Cardozo OBE MB ChB MD FRCOG: 15.09.50-21.09.23. Linda Cardozo教授OBE MB ChB MD FRCOG: 15.09.50-21.09.23。

IF 2.8 4区医学

Climacteric Pub Date : 2023-12-01 DOI: 10.1080/13697137.2023.2274189

Dudley Robinson, Tim Hillard

引用次数: 0