Climacteric最新文献

{"title":"Sexual dysfunction and quality of life in postmenopausal type 2 diabetes mellitus: clinical and laboratory factors.","authors":"Sandra Ester Alves, Márcia Silva Queiroz","doi":"10.1080/13697137.2025.2601007","DOIUrl":"10.1080/13697137.2025.2601007","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate female sexual dysfunction (FSD) in postmenopausal women with and without type 2 diabetes (T2D) and its relationship with clinical, laboratory and socioeconomic parameters and quality of life (QoL).</p><p><strong>Method: </strong>This cross-sectional study enrolled postmenopausal women with and without T2D not taking hormone replacement. Clinical and laboratory factors were assessed, and participants answered cardiovascular risk, socioeconomic, Short Form Health Survey 36 (SF-36) and Female Sexual Function Index (FSFI) questionnaires.</p><p><strong>Results: </strong>Postmenopausal women without diabetes (<i>n</i> = 105) and with a previous T2D diagnosis (<i>n</i> = 110) were similar in age, marital status, race/ethnicity, employment status, alcohol use and body mass index. Women with T2D showed higher glycemia, glycated hemoglobin, cholesterol, thyroid-stimulating hormone and cardiovascular risk factors. SF-36 scores were significantly lower in women with T2D and sexual dysfunction compared to those without diabetes. FSFI scores below 26.55 were associated with higher odds of FSD with increasing age, whereas vitality showed an inverse association.</p><p><strong>Conclusion: </strong>In postmenopausal women with T2D, reduced FSFI scores along with hypertension, hypothyroidism and elevated cardiometabolic risk were linked to poorer QoL. Age increased the odds of FSD, while vitality decreased them. These results underscore the multifactorial interaction of T2D, comorbidities and menopause in women's sexual health and well-being.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"402-408"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopausal transition and metabolic syndrome risk: insights from the Chinese PALM longitudinal cohort.","authors":"Jingbo Huang, Penghui Feng, Ruiyi Tang, Feiling Huang, Yubo Fan, Xuanjin Yang, Zhuolin Xie, Lingjin Yang, Xiaonan Ma, Keyang Yang, Runhua Zhang, Gaifen Liu, Min Luo, Rong Chen","doi":"10.1080/13697137.2025.2591300","DOIUrl":"10.1080/13697137.2025.2591300","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate trends of metabolic syndrome (MetS) and its components across the menopausal transition and to identify key metabolic risk factors in Chinese midlife women.</p><p><strong>Method: </strong>The longitudinal study included 841 women from the Peking Union Medical College Hospital Aging Longitudinal Cohort of Women in Midlife (PALM cohort, 2005-2024), classified by the Stages of Reproductive Aging Workshop +10 (STRAW +10) criteria. Repeated measures of metabolic indicators, sex hormones and sociodemographic factors were analyzed using generalized estimating equations.</p><p><strong>Results: </strong>MetS prevalence rose from 15.0% in the reproductive stage to 43.9% in late postmenopause. All components except reduced high-density lipoprotein cholesterol (HDL-C) increased progressively. After adjustment, perimenopause and postmenopause stages showed higher MetS odds than the reproductive stage (<i>p</i> = 0.008), with the highest observed in the early postmenopause stage (odds ratio = 1.796, 95% confidence interval = 1.224-2.634), primarily driven by central obesity and elevated triglycerides. Age, follicle stimulating hormone (FSH) and estradiol (E2) were independently associated with MetS risk. Lower education and poor self-rated health correlated with higher MetS risk. Vasomotor symptoms were significantly associated with central obesity (<i>p</i> = 0.012) and elevated triglycerides (<i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>The menopausal transition is a critical period for metabolic deterioration. Central obesity and elevated triglycerides are key markers. Early identification and targeted intervention are essential during this transition.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"381-395"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932485","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Female reproductive factors, genetic susceptibility and incident osteoporosis risk.","authors":"Zhong-Qiang Liu, Yu-Jun Xiong, Xiao Yu, Tian Lv, Hang-Yang Xu","doi":"10.1080/13697137.2026.2627565","DOIUrl":"10.1080/13697137.2026.2627565","url":null,"abstract":"<p><strong>Objective: </strong>Osteoporosis risk is shaped by both reproductive factors and genetic predisposition, yet their combined effects remain insufficiently studied.</p><p><strong>Method: </strong>A total of 49,885 women from the UK Biobank were analyzed, excluding those with baseline osteoporosis or missing reproductive data. Reproductive factors included age at menarche, menopause time/status, history of stillbirth, hysterectomy, oophorectomy and oral contraceptive (OC) use. Genetic susceptibility was assessed using the polygenic risk score (PRS). Cox models estimated associations, with restricted cubic splines testing non-linear trends. Kaplan-Meier curves and sensitivity analyses were performed.</p><p><strong>Results: </strong>Late menarche, premature ovarian insufficiency, menopausal status, stillbirth, hysterectomy and oophorectomy were linked to higher osteoporosis risk, while OC use was protective. Women with high PRS combined with adverse reproductive histories had the greatest risk. Additive interactions were evident between genetic risk and menopause, stillbirth, hysterectomy and oophorectomy, whereas other factors acted largely independently. Sensitivity analyses supported robustness.</p><p><strong>Conclusion: </strong>Both reproductive history and genetic susceptibility contribute to osteoporosis risk in women. Joint assessment of these factors may enhance risk stratification and inform personalized prevention.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"470-477"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147302947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between adverse life events, DNA methylation and risk of premature ovarian insufficiency.","authors":"Shuang Yuan, Liutong Wei, Junyan Sun, Yihui Fan, Meiling Li, Lulu Wang, Qiuwan Zhang, Qian Wang, Shengju Yin, Dongmei Lai","doi":"10.1080/13697137.2025.2610484","DOIUrl":"10.1080/13697137.2025.2610484","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess psychological and lifestyle risk factors for premature ovarian insufficiency (POI) and their association with DNA methylation.</p><p><strong>Methods: </strong>A case-control study was conducted in Shanghai (2017-2022), including 304 controls and 160 newly diagnosed cases with POI (diagnosed within the past 6 months). Cumulative adverse life events were assessed using the life event scale (LES), and genome-wide DNA methylation was evaluated in whole blood-derived DNA obtained from a sub-sample.</p><p><strong>Results: </strong>The median total event score for POI patients and control individuals was 48.5 and 20.0, respectively (<i>p</i> < 0.001). Participants experiencing more stressful life events (LES >32) were 2.33-fold more likely to have POI compared to controls (odds ratio 2.33, 95% confidence interval 1.53-3.56). Genome-wide DNA methylation analysis identified 5582 differentially methylated sites (DMSs) between POI patients and controls. Further analysis showed that higher negative life events scores were significantly associated with accelerated DNA methylation aging in the POI group (β = 0.06, <i>p</i> < 0.001).</p><p><strong>Conclusion: </strong>This case-control study revealed that cumulative stressful or adverse life events were associated with an increased risk of POI, and that accelerated epigenetic aging was correlated with chronic stress in POI patients. These findings suggest potential links that warrant further mechanistic investigation.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"435-444"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146060489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The use of conjugated estrogens and bazedoxifene for the management of vasomotor symptoms in premenopausal and menopausal patients with endometriosis: a systematic review.","authors":"Javier C Mejia-Gomez, Elizabeta Shprits, Carys Sosea, Brenna Leslie, Siddhi Mathur, Salwa Farooqi, Areeba Chaudhry, Vanessa Bacal, Ala Essalah, Nada Shaltout, Alison Shea, Corey Sermer, Sara Hojabri, Wendy Wolfman, Noah Stancati, Michelle Jacobson","doi":"10.1080/13697137.2026.2664747","DOIUrl":"10.1080/13697137.2026.2664747","url":null,"abstract":"<p><strong>Objective: </strong>This systematic review investigated the impact of conjugated estrogens/bazedoxifene (CE/BZA) for treating perimenopausal and menopausal symptoms in patients with a history of endometriosis.</p><p><strong>Method: </strong>The review followed PRISMA guidelines and was prospectively registered with PROSPERO (CRD42024617174). Without randomized controlled trials (RCTs), the Joanna Briggs Institute (JBI) Critical Appraisal Checklist for Case Reports and Case Series assessed methodology and risk of bias. An information specialist completed the search in June 2025 using Ovid MEDLINE, PubMed, Ovid EMBASE, and Web of Science, combining controlled vocabularies and keywords for dysmenorrhea, dyspareunia, endometriosis, perimenopausal, postmenopausal, menopause hormone therapy, Duavive, and CE/BZA. Eligible studies included RCTs, cohort studies, case reports, and case-control studies evaluating CE/BZA for vasomotor symptoms in premenopausal and menopausal endometriosis patients.</p><p><strong>Results: </strong>Of 1540 retrieved studies, two coauthors (J.C.M.-G., E.S.) independently screened titles and abstracts, selecting 20 for full-text review. Only two publications met inclusion criteria, one case report and one case series, representing nine patients (four detailed, five additional). No RCTs, cohort, or case-control studies directly addressed CE/BZA in endometriosis. Preliminary narrative evidence suggests pain and vasomotor symptom relief, though findings carry high risk of bias.</p><p><strong>Conclusion: </strong>Because bazedoxifene antagonizes estrogen receptors and endometriosis is estrogen-dependent, CE/BZA may alter systemic inflammation or endothelial function. Although preclinical models show reduced lesion size, human evidence remains extremely limited and biased, insufficient to assess lesion recurrence or vascular safety. CE/BZA is currently indicated only for postmenopausal vasomotor symptoms; preliminary anecdotal evidence suggests symptom improvement, but large-scale comparative trials are urgently needed to establish safety and efficacy in endometriosis.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"338-344"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148197575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A narrative review of energy expenditure and substrate oxidation during menopause.","authors":"Camille Marcantei, Lore Metz, Emma O'Donnell, Laurie Isacco","doi":"10.1080/13697137.2025.2610485","DOIUrl":"10.1080/13697137.2025.2610485","url":null,"abstract":"<p><p>The menopausal transition is characterized by numerous physiological changes associated with the hormonal modifications that occur during this period, such as increased body weight and visceral body fat, reduced energy expenditure and fat oxidation rates, and increased risk of cardiometabolic disorders. While the influence of ovarian hormones on the regulation of energy balance has been widely investigated, the effects of the menopausal transition, also called perimenopause, on the different compartments of energy expenditure (i.e. resting, sleeping, thermic effect of food and physical activity energy expenditure) are less described. Furthermore, substrate metabolism adaptations to the menopausal transition are also poorly described despite their significant influence on health. To address this knowledge gap, this narrative review considers the energetic adaptations of the resting and non-resting components during the menopausal transition, as well as central and peripheral estrogen-associated cellular mechanisms that may play a role. Although research on energetic adaptations during the menopausal transition remains limited, current evidence indicates declines in resting and sleeping energy expenditure and fat oxidation, as well as physical activity energy expenditure and peak fat oxidation. These alterations appear to result from central and peripheral adaptations triggered by the menopausal decline in estrogen and the concomitant rise in follicle stimulating hormone (FSH).</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"140-150"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147484810","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simulation-based model of menopause: hormonal changes and cardiovascular risk in a digital twin view.","authors":"Alexandre Vallée","doi":"10.1080/13697137.2025.2567693","DOIUrl":"10.1080/13697137.2025.2567693","url":null,"abstract":"<p><strong>Objective: </strong>Menopause is associated with profound hormonal changes, including declines in estradiol and progesterone and increases in follicle stimulating hormone (FSH) and luteinizing hormone (LH), which contribute to elevated cardiovascular disease (CVD) risk. Digital twin frameworks offer a novel approach to simulate these complex dynamics.</p><p><strong>Method: </strong>This study developed a semi-mechanistic digital twin model of menopause using 1000 simulated women (50% age ≥55 years, 50% age <55 years) followed over 90 days. Hormonal dynamics were modeled as cyclical in non-menopausal women and stable in postmenopausal women. Cardiovascular risk was assessed with linear mixed-effects models and generalized estimating equations, adjusting for age, body mass index and smoking.</p><p><strong>Results: </strong>The model reproduced expected patterns, with estradiol and progesterone peaks at ovulation and luteal phases in non-menopausal women, and stable, low levels in postmenopausal women, alongside elevated gonadotropins. After adjustment, menopause remained significantly associated with hormonal changes and CVD risk (<i>p</i> < 0.001). CVD-related differences were more pronounced in non-menopausal women, where estradiol peaks and luteal progesterone amplitudes were attenuated.</p><p><strong>Conclusion: </strong>This proof of concept highlights the potential of digital twin models to capture menopause-related hormonal dynamics and their cardiovascular implications. Future work should integrate real-world data, perimenopausal variability and ethical governance to enhance clinical translation.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"239-247"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145430471","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Twenty-year cardiovascular disease incidence in menopausal women: insights from the ATTICA study.","authors":"Christina Chrysohoou, Panagiotis Iliakis, Anna Pitsillidi, Eleni Manta, Fotios Barkas, Evangelos Liberopoulos, Petros P Sfikakis, Christos Pitsavos, Costas Tsioufis, Demosthenes Panagiotakos","doi":"10.1080/13697137.2025.2567691","DOIUrl":"10.1080/13697137.2025.2567691","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to examine the 20-year incidence of cardiovascular disease (CVD) in menopausal women, exploring the interplay of traditional and menopause-specific risk factors.</p><p><strong>Method: </strong>The ATTICA study is a prospective cohort survey established in 2001-2002, with three consecutive follow-ups performed in 2006, 2012 and 2022. A total of 1001 women with complete data for CVD evaluation comprised the sample of the current study. For the purposes of this analysis, women were classified according to their menopausal status (at menopause, 276 out of 1001 women [27.6%]).</p><p><strong>Results: </strong>The 20-year cumulative CVD incidence was 321 cases among 1001 women (32%); 274 out of the 337 (81.3%) who were at menopause developed CVD, whereas 47 out of 664 at premenopause developed CVD (7.1%). Age-adjusted analysis revealed that postmenopausal women had 2.25 times (95% confidence interval: 1.20, 4.24) higher risk of CVD, compared to women not at menopause. The fully adjusted model revealed that history of diabetes and hypercholesterolemia were significant predictors for the 20-year-CVD events. Moreover, high-sensitivity C-reactive protein was a significant predictor for CVD events only in women aged above 52 years at menopause.</p><p><strong>Conclusion: </strong>Postmenopausal women had an age-adjusted 2.25 times higher 20-year risk of CVD, as compared to women who were not at menopause. Prevailed hypercholesterolemia and diabetes were the most important determinants for long-term CVD events, whereas chronic systemic inflammation had significant predictive value only in women aged above 52 years at menopause.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"231-238"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145343958","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Healthy aging in midlife and menopausal transition in Asia: nutrient synergy with dietary supplements.","authors":"Unnop Jaisamrarn, Maria Antonia Habana, Premitha Damodaran, Mya Thway Tint, Hai-Hua Chuang, David J Hunter, Brij Mohan Makkar, V Padma, Sang Woo Oh, Ashish Krishna, Vanita Dahia, Marc Dexter Macalintal","doi":"10.1080/13697137.2025.2567689","DOIUrl":"10.1080/13697137.2025.2567689","url":null,"abstract":"<p><p>Women in early midlife often experience specific health issues due to aging and the menopausal transition. Hormonal changes, systemic chronic inflammation and micronutrient deficiencies contribute to symptoms such as vasomotor disturbances, metabolic syndrome, neurocognitive decline and reduced mobility, which can adversely affect overall health and quality of life. However, the menopausal transition also offers opportunities for improving health and preventing diseases. Many women use dietary supplements as a form of complementary and alternative medicine (CAM) to manage these complex challenges during this life stage. Given the multifaceted nature of these health concerns, an integrated approach that combines dietary supplements with conventional medicine and harnesses nutrient synergy for enhanced benefits should be considered. This article examines current evidence on the use of multivitamins, minerals and dietary supplements (including those containing phytonutrients and other CAMs) for health issues during early midlife and the menopausal transition. Although current evidence suggests that multi-nutrient dietary supplementation combinations are promising, further research is needed to verify their effectiveness and evaluate potential interactions with standard treatments across diverse populations. The successful integration of dietary supplements alongside conventional medicine during the menopausal transition will also require personalized care, support from healthcare professionals and public education.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"151-164"},"PeriodicalIF":3.2,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145437582","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Complementary therapies for management of menopausal symptoms: a systematic review to inform the update of the International Menopause Society recommendations on women's midlife health.","authors":"Alison Maunder, Amelia K Mardon, Vibhuti Rao, Sophia Torkel, Najwa-Joelle Metri, Jing Liu, Guoyan Yang, Nora Giese, Evangeline Mantzioris, Nur K Abdul Jafar, Geovanna E Rodrigues de Souza, Ieman Al-Kanini, Lorena Romero, Nick Panay, Hugo Pedder, Carolyn Ee","doi":"10.1080/13697137.2025.2584061","DOIUrl":"10.1080/13697137.2025.2584061","url":null,"abstract":"<p><strong>Objective: </strong>Menopausal hormone therapy is standard treatment, but some women use complementary therapies. This review examines complementary therapies for menopause to inform International Menopause Society (IMS) recommendations.</p><p><strong>Method: </strong>A systematic search of six databases (January 2022-December 2024) identified randomized controlled trials (RCTs) and systematic reviews on complementary therapies for menopause. Outcomes included menopausal, vasomotor, genitourinary, cardiometabolic, sleep symptoms, bone health and safety. The study quality and certainty of evidence were evaluated using Cochrane Risk of Bias (RoB2), A MeaSurement Tool to Assess Systematic Reviews (AMSTAR 2) and Grading of Recommendations, Assessment, Development, and Evaluation (GRADE).</p><p><strong>Results: </strong>From 3187 citations, 158 studies were included: one overview, 36 meta-analyses, seven systematic reviews and 114 RCTs. While promising evidence was found for acupuncture, Chinese herbal medicine (CHM), herbs, nutrients, mind-body/touch therapies for a variety of symptoms, most was of low/very low certainty. High-certainty evidence supports vitamin D safety; and moderate-certainty evidence supports black cohosh (vasomotor/menopausal symptoms), CHM (menopausal symptoms, sleep, blood pressure), acupuncture + CHM (sleep) and vitamin D (fracture risk). Most complementary therapies are safe.</p><p><strong>Conclusion: </strong>Vitamin D, black cohosh, CHM and acupuncture + CHM may improve some menopausal symptoms, but overall evidence remains limited. More rigorous research is needed on the efficacy and safety of complementary therapies for menopause.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"165-209"},"PeriodicalIF":3.9,"publicationDate":"2026-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910489","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}