Climacteric最新文献

{"title":"Menopausal hormone therapy and pulmonary diseases.","authors":"Márcio Alexandre Hipólito Rodrigues, Anne Gompel","doi":"10.1080/13697137.2026.2671756","DOIUrl":"10.1080/13697137.2026.2671756","url":null,"abstract":"<p><p>Menopause is accompanied by loss of ovarian estrogen and progesterone production and by age-related changes in circulating androgens, with implications for respiratory physiology and chronic pulmonary disease. Sex steroids influence lung development, immune responses, airway tone, vascular remodeling and pathways involved in lung carcinogenesis. Epidemiological evidence linking menopausal hormone therapy (MHT) to asthma is heterogeneous; some cohorts show increased incident asthma or exacerbations, particularly with estrogen therapy and in specific subgroups, whereas others suggest preserved lung function or reduced late-onset asthma. Data on chronic obstructive pulmonary disease remain limited and inconsistent. In pulmonary hypertension, evidence is conflicting, and clinical decisions must weigh thrombotic risk, strongly influenced by the route of estrogen administration. Studies on obstructive sleep apnea and sleep-disordered breathing suggest possible modest benefits of MHT in selected populations but are methodologically heterogeneous. For lung cancer, large cohorts, meta-analyses and randomized trials essentially show no clear increase in incidence with MHT and suggest potential survival advantages in some subgroups. Overall, MHT use in women with or at risk for pulmonary disease should be individualized, integrating symptom burden, cardiometabolic and respiratory risk, disease phenotype and formulation/route.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"327-337"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148155556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A preliminary pilot study to address design issues related to research on potential association of hormone therapy and adhesive capsulitis.","authors":"Emily K Reinke, Anne C Ford, Elizabeth Wahl, June Kennedy, Emily Poehlein, Cynthia L Green, Eliana Saltzman, Jocelyn R Wittstein","doi":"10.1080/13697137.2026.2615391","DOIUrl":"10.1080/13697137.2026.2615391","url":null,"abstract":"<p><strong>Objective: </strong>Adhesive capsulitis (AC) is considered idiopathic, yet typically affects women aged 40-60 years. The purpose of this study was to determine whether hormone therapy is protective against AC in menopausal women. The study hypothesized that patients prescribed hormone therapy would have lower odds of AC than those not using hormone therapy.</p><p><strong>Method: </strong>Medical record extraction for a single health maintenance organization was used to identify postmenopausal women aged 40- 60 years and assess the utilization of hormone therapy and diagnosis of AC. The distribution of AC and endocrine disorders was compared between treatment groups using chi-squared tests and the odds ratio (OR) was reported.</p><p><strong>Results: </strong>The cohort included 1952 patients (152 hormone therapy, 1800 without hormone therapy). No statistically significant differences were found between treatment groups for endocrine disorders. A higher percentage of AC was noted in patients without hormone therapy compared to patients with hormone therapy (7.65% vs. 3.95%), although the association was not statistically significant (OR 1.99; 95% confidence interval 0.86-4.58; <i>p</i> = 0.10).</p><p><strong>Conclusion: </strong>This pilot study did not demonstrate a statistically significant difference in odds of AC in menopausal women with and without hormone therapy. Larger prospective studies are needed to further explore potential protective effects of hormone therapy against AC.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"478-483"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146084408","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Follicle stimulating hormone, luteinizing hormone and adiposity trajectories in postmenopausal women.","authors":"Yihua Yue, Sarah M Lima, Kathleen M Hovey, Jennifer W Bea, Jean Wactawski-Wende, JoAnn E Manson, Denise Roe, Janet L Funk, Andrew O Odegaard, Shelby G Ziller, Robert Wallace, Su Yon Jung, Jane A Cauley, Heather M Ochs-Balcom","doi":"10.1080/13697137.2025.2595986","DOIUrl":"10.1080/13697137.2025.2595986","url":null,"abstract":"<p><strong>Objective: </strong>Postmenopause is characterized by changes in reproductive hormones and body composition. Preclinical evidence suggests that follicle stimulating hormone (FSH) may increase adiposity, but epidemiologic research is limited. This study examined whether postmenopausal FSH and luteinizing hormone (LH) are related to adiposity changes.</p><p><strong>Method: </strong>The sample included 675 postmenopausal women enrolled in the Women's Health Initiative (WHI) Buffalo Osteoporosis and Periodontal Disease (OsteoPerio) study with dual-energy X-ray absorptiometry measures. Adiposity measures included visceral adipose tissue (VAT), subcutaneous adipose tissue, body mass index, and total and percent body fat. Group-based trajectory models and generalized estimating equation models estimated associations of baseline FSH and LH with 17-year adipose trajectories and longitudinal measures of adiposity, respectively.</p><p><strong>Results: </strong>The study estimated three trajectories for adiposity measures, corresponding to low, medium and high levels of adiposity over time. Higher baseline concentration of FSH and LH was associated with reductions in adiposity measures over time. An increase of 1 mIU/ml in FSH was associated with a 0.55 cm² reduction in VAT (95% confidence interval [CI]: -0.69, -0.40); and an increase of 1 mIU/ml in LH was associated with a 0.81 cm² reduction in VAT (95% CI: -1.09, -0.52).</p><p><strong>Conclusion: </strong>Higher circulating FSH and LH were associated with lower adipose trajectories and lower adiposity levels in older postmenopausal women, counter to our hypothesis. Future research is needed on the relationship between gonadotropins and adiposity during the postmenopausal period.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"409-415"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145809779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Treatment patterns of hormone therapy for menopause-associated vasomotor symptoms: analysis of the HIRA database in South Korea.","authors":"Jung-Ho Shin, Geum Joon Cho, Farid Abdul Hadi, Soyoung Kim, Robert Snijder, Mohamed Soliman, Sharon Yu Lin Chua, Cindy Thiow Koon Lim","doi":"10.1080/13697137.2026.2615389","DOIUrl":"10.1080/13697137.2026.2615389","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to describe treatment patterns of hormone therapy (HT) prescribed for menopause-associated vasomotor symptoms (VMS), characteristics of women who received HT and events of interest using the Health Insurance and Review Assessment (HIRA) database in South Korea.</p><p><strong>Methods: </strong>Eligible patients were women aged 40-65 years who were first dispensed HT in 2015 and diagnosed with menopause-associated VMS. Patients were followed until death or the end of the data period, 31 December 2020, whichever occurred earlier.</p><p><strong>Results: </strong>The analyses included 102,535 patients. Median age at VMS diagnosis was 52 years. Time from diagnosis to HT dispensation was <3 months in 77.6% (<i>n</i> = 79,559) of patients; 51.3% (<i>n</i> = 52,648) received HT for <3 months and 27.9% (<i>n</i> = 28,634) for >1 year. Most patients (60.5%, <i>n</i> = 62,064) had a medical condition of interest at baseline; 27.0% (<i>n</i> = 27,655) had a contraindication and 39.7% (<i>n</i> = 40,667) had a precaution for HT. Tibolone and combined estrogen with progestogen were the most common HTs.</p><p><strong>Conclusion: </strong>While the number of patients who received HT constituted approximately 1% of the estimated 9.31 million menopausal population in South Korea, most patients prescribed HT had a medical condition of interest at baseline that was a contraindication or precaution for HT. There is a need to identify additional well-tolerated, effective alternatives.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"429-434"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146164301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global burden of gastroesophageal reflux disease in women of perimenopausal age: trends and forecasts.","authors":"Yijun Zheng, Haoen Li, Yitong Zheng, Yanping Wu, Yujie Wen, Jiaxuan Zhou, Jia Wei, Wenting Zhang, Tong Kang, Bin Qin, Jiong Jiang, Jun Zhang, Yan Cheng","doi":"10.1080/13697137.2025.2610483","DOIUrl":"10.1080/13697137.2025.2610483","url":null,"abstract":"<p><strong>Objective: </strong>Gastroesophageal reflux disease (GERD) is a highly prevalent disorder that diminishes quality of life. Hormonal fluctuations during the perimenopausal transition (age 45-54 years) may heighten susceptibility to GERD, yet the magnitude of the burden in this group remains poorly characterized. This study aims to quantify GERD trends in women of perimenopausal age and forecast disease trajectories to 2045.</p><p><strong>Method: </strong>Data from the 2021 Global Burden of Disease (GBD) database were utilized. Age-standardized rates were calculated, annual percentage changes were estimated (EAPC) and Bayesian age-period-cohort (BAPC) models were employed to project trends to 2045.</p><p><strong>Results: </strong>From 1990 to 2021, the global age-standardized prevalence rate (ASPR) and age-standardized disability-adjusted life year rate (ASDR) of GERD in women of perimenopausal age exhibited a decreasing trend (EAPC for both: -0.09, 95% confidence interval [CI] - 0.14 to -0.04), despite a marked rise in the prevalent cases. Latin America recorded the highest ASDR. Middle Socio-demographic Index regions experienced the greatest growth in prevalent cases. The BAPC model predicts a rise in the age-standardized incidence rate.</p><p><strong>Conclusion: </strong>The burden of GERD in women of perimenopausal age exhibits significant global heterogeneity. Incidence rates have risen persistently and are projected to increase through 2045.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"416-428"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146050199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intermittent walking training improves thyroid function and cardiometabolic risk factors in postmenopausal women.","authors":"Wissal Abassi, Nejmeddine Ouerghi, Nidhal Jebabli, Wissem Dhahbi, Nadhir Hammami, Noomen Guelmami, Anissa Bouassida, Moncef Feki, Katja Weiss, Thomas Rosemann, Ismail Dergaa, Beat Knechtle","doi":"10.1080/13697137.2025.2601008","DOIUrl":"10.1080/13697137.2025.2601008","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the impact of a 10-week moderate intermittent walking training (MIWT) program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women.</p><p><strong>Methods: </strong>Thirty-six obese postmenopausal women (body mass index ≥ 30 kg.m^-2, aged 50-60 years) were randomized to either the MIWT group (<i>n</i> = 18) or the control group (CG; <i>n</i> = 18). Participants performed the MIWT program for four sessions per week (five repetitions of the 6-min walking test [6MWT] at 60-80% of the distance covered in the 6-min walking test [6MWD], interspersed by 6 min of active recovery between repetitions). Body composition, thyroid hormones (thyroid stimulating hormone [TSH] and thyroxine-free [FT4]), lipid profile (triglycerides [TRG], total cholesterol [TC], high-density lipoprotein cholesterol [HDL-C] and low-density lipoprotein cholesterol [LDL-C]), blood pressure and aerobic fitness (6MWT) were determined before and after the MIWT.</p><p><strong>Results: </strong>The MIWT resulted in significant reductions in body composition (<i>p</i> < 0.05), TSH (-5.29%, <i>p</i> = 0.019, <i>d</i> = 0.16), FT4 (-1.84%, <i>p</i> = 0.032, <i>d</i> = 0.28), TRG (-7.29%, <i>p</i> = 0.003, <i>d</i> = 0.27), TC (-4.98%, <i>p</i> = 0.003, <i>d</i> = 0.31), LDL-C (-10.08%, <i>p</i> = 0.003, <i>d</i> = 0.51) and SBP (-2.57%, <i>p</i> = 0.035, <i>d</i> = 0.66), and significant increases in HDL-C (13.36%, <i>p</i> = 0.020, <i>d</i> = 0.52) and 6MWD (2.81%, <i>p</i> = 0.031, <i>d</i> = 0.51).</p><p><strong>Conclusions: </strong>A 10-week MIWT program modestly improved thyroid hormones, cardiometabolic risk and functional capacity in obese postmenopausal women without adverse effects. MIWT is an accessible and low-impact intervention suitable for integration into routine clinical practice to prevent and manage thyroid-related and cardiometabolic disorders in this high-risk population.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"372-380"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932496","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Body composition and self-perception of age and health in resistance-trained postmenopausal women.","authors":"Alberto Nishimura, Milton Rocha Moraes, Elbert Wander Cantão, Patrício Lopes Araújo Leite, Larissa Alves Maciel, Caio Victor Sousa, Rita Cristine Barboza Patricio, Samuel da Silva Aguiar, Carmen Sílvia Grubert Campbell, Hélcio Rossi Gonçalves, Herbert Gustavo Simões","doi":"10.1080/13697137.2025.2601006","DOIUrl":"10.1080/13697137.2025.2601006","url":null,"abstract":"<p><strong>Objective: </strong>This study investigated the associations among subjective age, age perception ratio (APR), self-rated health, happiness score and body composition in postmenopausal women.</p><p><strong>Method: </strong>A total of 46 postmenopausal women aged 50-69 years participated, divided into a resistance training group (RTG; <i>n</i> = 24; age 58.2 ± 5.1 years, ≥7 years training) and an untrained group (UNG; <i>n</i> = 22; age 58.5 ± 4.1 years). The APR, self-rated health and happiness were assessed and compared. Body composition variables included the waist-to-hip ratio, waist-to-height ratio, body fat percentage and absolute fat mass. Statistical analyses included <i>t</i>-tests, correlations and multiple regression to predict APR.</p><p><strong>Results: </strong>Women in the RTG perceived themselves as 27.1 ± 11.3% younger than their actual age, significantly more than the 10.6 ± 17.8% in the UNG (<i>p</i> = 0.001). Self-rated health was higher in the RTG (4.1 ± 0.7) than in the UNG (3.1 ± 1.0; <i>p</i> < 0.001), with no group differences in happiness (<i>p</i> = 0.799). The APR correlated with self-rated health (<i>r</i> = 0.689; <i>p</i> < 0.001) and happiness (<i>r</i> = 0.435; <i>p</i> = 0.003). Regression showed that self-rated health, happiness and waist-to-hip ratio predicted 56.7% of APR variance (<i>R</i>² = 0.567; <i>p</i> < 0.001). The RTG also had better body composition values than the UNG.</p><p><strong>Conclusion: </strong>Postmenopausal women engaged in long-term resistance training showed a higher APR and self-rated health, likely associated with improved body composition and younger self-perception of age.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"364-371"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145932533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Does MHT prevent or treat cognitive decline? Recent data converge on an answer.","authors":"Pauline M Maki","doi":"10.1080/13697137.2026.2671583","DOIUrl":"10.1080/13697137.2026.2671583","url":null,"abstract":"","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"321-323"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147980885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Do menopausal symptoms signal early biological aging? Mitochondrial, endocrine and clinical insights.","authors":"Juan E Blümel, Peter Chedraui, María S Vallejo","doi":"10.1080/13697137.2026.2663898","DOIUrl":"10.1080/13697137.2026.2663898","url":null,"abstract":"<p><p>The menopausal transition represents a pivotal period in female aging, marked by profound endocrine, metabolic and cellular shifts. Increasing evidence indicates that menopausal symptoms - vasomotor instability, sleep disturbances, fatigue and cognitive complaints - are more than consequences of estrogen withdrawal, and may serve as a potential clinical indicator of biological aging. Experimental and clinical data suggest that declining estrogen signaling contributes to mitochondrial dysfunction, inflammation and telomere attrition, processes that are closely linked to cellular senescence and tissue deterioration. In addition to estrogen decline, the menopausal transition involves broader endocrine changes. Rising follicle stimulating hormone (FSH) levels, alteration in androgen balance and cortisol dysregulation of the hypothalamic-pituitary-adrenal axis may influence metabolic regulation, musculoskeletal health, stress physiology and body composition. Through these mechanisms, menopausal hormonal changes may contribute to increased cardiometabolic, musculoskeletal and neurocognitive vulnerability in midlife women. Clinical observations increasingly show that severe menopausal symptoms are associated with adverse cardiometabolic profiles, vascular dysfunction and markers of accelerated biological aging. Sleep disturbances and fatigue may further exacerbate metabolic dysregulation and systemic vulnerability, while cognitive complaints may reflect neuroinflammatory and vascular processes associated with aging. By restoring estrogen signaling, menopausal hormone therapy alleviates menopausal symptoms and may influence biological pathways involved in aging. Whether these effects translate into a modification of the aging trajectory remains unclear.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"358-363"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147811727","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between menopausal status and physical function: a systematic review and meta-analysis.","authors":"Pedro R S Macêdo, Sabrina G G F Macêdo, Ananília Regina Silva Cavalcante, Maithê Avelino Salustiano, Mateus D A Lima, Javier Jerez-Roig, Saionara M A Câmara","doi":"10.1080/13697137.2026.2651720","DOIUrl":"10.1080/13697137.2026.2651720","url":null,"abstract":"<p><p>The aim of this systematic review with meta-analysis was to analyze the association between menopausal status and physical function. This review of observational studies followed the Preferred Reporting Items for Systematic Review and Meta-Analysis (PRISMA) statement and was registered in PROSPERO. Searches were performed in the PubMed, Cochrane Library, SciELO, LILACS and Web of Science databases. RevMan 5 was used for meta-analysis. Twenty-six studies were included, and 80.8% showed significant associations between menopausal status and physical function. Compared to postmenopausal women, premenopausal (mean difference [MD] = 2.72, <i>p</i> < 0.001) and perimenopausal (MD = 1.68, <i>p</i> < 0.001) women had stronger handgrip strength in meta-analysis of unadjusted results. Associations remained significant when considering studies with results adjusted for covariates. Results were similar when considering different socioeconomic contexts. Premenopausal women also had stronger pinch and knee extension strength, better performance in the single-leg balance tests with eyes closed and open, and better self-reported physical function and functional limitation due to physical problems than postmenopausal women in meta-analysis with unadjusted results. Meta-analyses of adjusted results were conducted for self-reported measures, but differences lost significance. The menopausal transition seems to be a critical period during which physical function tends to decline, underscoring the importance of implementing healthcare strategies for women during this phase.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"345-357"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}