Climacteric最新文献_第8页

The prevalence and severity of vasomotor and sexual symptoms among refugee women in Australia. 澳大利亚难民妇女中血管运动症状和性症状的发生率和严重程度。

IF 2.9 4区医学

Climacteric Pub Date : 2024-08-01 Epub Date: 2024-07-18 DOI: 10.1080/13697137.2024.2376183

Maryam Jahangirifar, Rakibul M Islam, Susan R Davis, Ensieh Fooladi

{"title":"The prevalence and severity of vasomotor and sexual symptoms among refugee women in Australia.","authors":"Maryam Jahangirifar, Rakibul M Islam, Susan R Davis, Ensieh Fooladi","doi":"10.1080/13697137.2024.2376183","DOIUrl":"10.1080/13697137.2024.2376183","url":null,"abstract":"Objective: This study aimed to document the prevalence and severity of vasomotor symptoms (VMS) and sexual symptoms among refugee women in Melbourne, Australia.Methods: This cross-sectional study included refugee women, aged 18-63 years, recruited from community centers and social media between February and July 2023. The Menopause-specific Quality of Life (MENQOL) questionnaire measured VMS and sexual symptoms. The scores were compared between different menopausal states.Results: Of 333 participants, 62.8% were premenopausal, 8.0% perimenopausal and 29.2% postmenopausal, with a median age of 40 years (range 18-63 years). Moderate-severe VMS was most prevalent amongst perimenopausal (20.8%; 95% confidence interval [CI]: 8.9-41.4%) versus postmenopausal (9.5%; 95% CI: 5.0-17.3%) and premenopausal (0%) women. Moderate-severe sexual symptoms affected 15.8% (95% CI: 5.2-39.3%) of perimenopausal and 16.9% (95% CI: 10.4-26.1%) of postmenopausal women versus 1.4% (95% CI: 0.3-5.3%) of premenopausal women. Perimenopausal and postmenopausal women had higher VMS and sexual symptom scores than premenopausal women (both p < 0.0001); the scores were also higher in perimenopausal women than postmenopausal women (p = 0.016 and p = 0.013, respectively).Conclusion: While perimenopausal and postmenopausal VMS and sexual symptoms are not uncommon amongst refugee women, these symptoms were less prevalent in postmenopausal refugees than in the non-refugee population. Further research is warranted to confirm and expand on these findings.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"398-405"},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Therapeutic effects of curculigoside on cyclophosphamide-induced premature ovarian failure in mice. 莪术苷对环磷酰胺诱导的小鼠卵巢早衰的治疗作用

IF 2.9 4区医学

Climacteric Pub Date : 2024-08-01 Epub Date: 2024-06-19 DOI: 10.1080/13697137.2024.2354742

Yuhao Meng, Yinjuan Lyu, Jian Gong, Yue Zou, Xiaocui Jiang, Min Xiao, Jianfang Guo

{"title":"Therapeutic effects of curculigoside on cyclophosphamide-induced premature ovarian failure in mice.","authors":"Yuhao Meng, Yinjuan Lyu, Jian Gong, Yue Zou, Xiaocui Jiang, Min Xiao, Jianfang Guo","doi":"10.1080/13697137.2024.2354742","DOIUrl":"10.1080/13697137.2024.2354742","url":null,"abstract":"Objective: The main purpose of this study was to elucidate the anti-apoptotic effects of curculigoside (CUR) on ovarian granulosa cells (GCs) in a mouse model of cyclophosphamide (CTX)-induced premature ovarian failure (POF).Method: Intraperitoneal injection of CTX (100 mg/kg body weight) induced POF in mice. Thirty-six female mice were divided into six groups: blank group; POF model group; low-dose CUR group; medium-dose CUR group; high-dose CUR group; and estradiol benzoate group. Mice were orally administered for 28 consecutive days. Twenty-four hours after the completion of treatment, mice were weighed and euthanized, and blood was collected from the eyeball under anesthesia. The ovaries were surgically separated and weighed, and the ovarian index was calculated. Hematoxylin-eosin (HE) staining was used to observe follicular development and corpus luteum morphology in the ovaries. Serum levels of follicle stimulating hormone (FSH), anti-Müllerian hormone (AMH) and estradiol (E2) were measured. Superoxide dismutase (SOD) activity, glutathione peroxidase (GSH-Px) content and malondialdehyde (MDA) levels in ovarian tissue were determined. The GC apoptosis level was measured. Western blotting was used to detect protein expression levels of Beclin-1, LC3, P62, AKT, p-AKT, mTOR and p-mTOR in the ovaries.Results: The results showed that CUR can improve body weight and ovarian index; promote follicular development and reduce follicular atresia; improve FSH, AMH and E2 levels; downregulate MDA levels and restore antioxidant enzyme activity; inhibit the autophagy level; activate the AKT/mTOR signaling pathway; and alleviate GC apoptosis.Conclusion: CUR improves POF by activating the AKT/mTOR signaling pathway, inhibiting autophagy and alleviating GC apoptosis.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"421-432"},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Acupuncture and Chinese herbal medicine for menopausal mood disorder: a randomized controlled trial [Letter]. 针灸和中药治疗更年期情绪障碍：随机对照试验 [信]。

IF 2.9 4区医学

Climacteric Pub Date : 2024-08-01 Epub Date: 2024-05-30 DOI: 10.1080/13697137.2024.2354756

Yawen Cai, Zeming Wu, Jinming Zhang, Lingjie Liu, Yijun Xin

引用次数: 0

Mental health during the COVID-19 pandemic: the importance of social support in midlife women. COVID-19 流行期间的心理健康：社会支持对中年女性的重要性。

IF 2.9 4区医学

Climacteric Pub Date : 2024-08-01 Epub Date: 2024-05-02 DOI: 10.1080/13697137.2024.2340476

Elizabeth S Wenzel, Jacob L Van Doorn, Rachel A Schroeder, Beau Ances, Susan Bookheimer, Melissa Terpstra, Roger P Woods, Pauline M Maki

{"title":"Mental health during the COVID-19 pandemic: the importance of social support in midlife women.","authors":"Elizabeth S Wenzel, Jacob L Van Doorn, Rachel A Schroeder, Beau Ances, Susan Bookheimer, Melissa Terpstra, Roger P Woods, Pauline M Maki","doi":"10.1080/13697137.2024.2340476","DOIUrl":"10.1080/13697137.2024.2340476","url":null,"abstract":"Objective: This study aimed to examine sex differences in factors associated with mood and anxiety in midlife men and women during the COVID-19 pandemic.Methods: During a remote visit, 312 adults aged 40-60 years (167 female; 23.6% perimenopausal) from the Human Connectome Project in Aging completed PROMIS measures of depression, anxiety and anger/irritability; perceived stress; and questions about social support, financial stress and menopause stage. Multivariate linear regression models assessed sex differences in mental health and the association of social support, financial stress and menopause stage with mental health.Results: Anxiety was higher in women than in men (b = 2.39, p = 0.02). For women only, decreased social support was associated with increased anxiety (b = -2.26, p = 0.002), anger/irritability (b = -1.89, p = 0.02) and stress (b = -1.67, p = 0.002). For women only, not having close family was associated with increased depressive symptoms (b = -6.60, p = 0.01) and stress (b = -7.03, p < 0.001). For both sexes, having children was associated with lower depressive symptoms (b = -3.08, p = 0.002), anxiety (b = -1.93, p = 0.07), anger/irritability (b = -2.73, p = 0.02) and stress (b = -1.44, p = 0.07). Menopause stage was unrelated to mental health.Conclusion: Social support, but not financial stress, influenced mental health during the COVID-19 pandemic at midlife, particularly for women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"373-381"},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11362980/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140847629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The road to Melbourne (take two). 通往墨尔本之路（第二场）。

IF 2.9 4区医学

Climacteric Pub Date : 2024-08-01 Epub Date: 2024-06-27 DOI: 10.1080/13697137.2024.2367379

Tim Hillard, Rod Baber, Tobie de Villiers

引用次数: 0

Neuroprotective effect of hormone replacement therapy: a review of the literature. 激素替代疗法的神经保护作用：文献综述。

IF 2.9 4区医学

Climacteric Pub Date : 2024-08-01 Epub Date: 2024-06-11 DOI: 10.1080/13697137.2024.2354759

Camilo Rueda Beltz, Brandon Alejandro Muñoz Vargas, Isabella Davila Neri, Diana Marcela Diaz Quijano

{"title":"Neuroprotective effect of hormone replacement therapy: a review of the literature.","authors":"Camilo Rueda Beltz, Brandon Alejandro Muñoz Vargas, Isabella Davila Neri, Diana Marcela Diaz Quijano","doi":"10.1080/13697137.2024.2354759","DOIUrl":"10.1080/13697137.2024.2354759","url":null,"abstract":"Objective: Menopause is a physiological period characterized by the cessation of ovarian activity. Sequential changes during this transition affect multiple systems, including the brain. Sixty percent of women experience cognitive impairment. The objective of this review is to show the neuroprotective effect of hormone replacement therapy (HRT) through the different scales and whether there is a benefit of this in women.Method: A search was conducted in six databases. Eligibility criteria included women within 10 years of menopause, receiving HRT controlled with placebo, studies lasting more than 6 months and women without a history of chronic underlying pathology.Results: A total of nine randomized controlled trials met the inclusion criteria. Regarding memory, two studies reported better performance of HRT with a significant odds ratio (OR) of 0.67; regarding attention, one study reported potential improvement in women receiving HRT with a significant OR of 0.87; and neuroimaging assessment found an increase in ventricular volume compared to placebo over a 3-year period.Conclusions: The early initiation of menopausal HRT in healthy women appears to yield a positive effect on certain cognitive aspects, such as attention and cortical volume in the central nervous system. These findings should be confirmed through future prospective studies.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"351-356"},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141305556","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hormone replacement therapy and myocardial infarction and stroke in postmenopausal Korean women. 绝经后韩国妇女的激素替代疗法与心肌梗死和中风。

IF 2.9 4区医学

Climacteric Pub Date : 2024-08-01 Epub Date: 2024-06-19 DOI: 10.1080/13697137.2024.2354728

Jin Kyung Baek, Hee Yon Kim, Min Jin Kang, Eun A Choi, Jae Kyung Lee, Eui Hyeok Kim, Seok Kyo Seo

{"title":"Hormone replacement therapy and myocardial infarction and stroke in postmenopausal Korean women.","authors":"Jin Kyung Baek, Hee Yon Kim, Min Jin Kang, Eun A Choi, Jae Kyung Lee, Eui Hyeok Kim, Seok Kyo Seo","doi":"10.1080/13697137.2024.2354728","DOIUrl":"10.1080/13697137.2024.2354728","url":null,"abstract":"Objective: This study aimed to investigate the association of hormone replacement therapy (HRT) use, type, duration and age of commencement with myocardial infarction (MI) and stroke in postmenopausal Korean women.Methods: This nested case-control study used data from the National Health Insurance Service database to analyze 2017 data from women aged ≥50 years and diagnosed with natural menopause between 2004 and 2007. Among 356,160 eligible women, 36,446 used HRT for ≥1 year and 319,714 did not (controls). These two groups were matched 1:1 for statistical analysis. Type and duration were categorized into three categories.Results: Women who started estrogen-progestogen therapy (EPT) or estrogen therapy (ET) in their 50s, or EPT or tibolone in their ≥60s exhibited a lower stroke risk than controls. MI risk was lower among women who used tibolone - regardless of duration - or EPT or ET for 1-3 years than among controls. Stroke risk was lower with tibolone use for ≥5 years or with EPT or ET use for 1-3 years or ≥5 years than non-users.Conclusion: Our study may support the beneficial effect of HRT by showing that Korean postmenopausal women who used HRT at a relatively younger and healthier age had a relative benefit for MI and stroke.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"406-412"},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141579127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Adherence to the Mediterranean diet is associated with handgrip strength in postmenopausal women. 坚持地中海饮食与绝经后妇女的握力有关。

IF 2.9 4区医学

Climacteric Pub Date : 2024-08-01 Epub Date: 2024-07-01 DOI: 10.1080/13697137.2024.2368484

Virginia Lampropoulou, Ilianna Karagkouni, Eleni Armeni, Panagiota Chatzivasileiou, Peter Chedraui, Loraina Kontou, Areti Augoulea, George Kaparos, Theodoros Panoskaltsis, Andreas Alexandrou, Irene Lambrinoudaki

{"title":"Adherence to the Mediterranean diet is associated with handgrip strength in postmenopausal women.","authors":"Virginia Lampropoulou, Ilianna Karagkouni, Eleni Armeni, Panagiota Chatzivasileiou, Peter Chedraui, Loraina Kontou, Areti Augoulea, George Kaparos, Theodoros Panoskaltsis, Andreas Alexandrou, Irene Lambrinoudaki","doi":"10.1080/13697137.2024.2368484","DOIUrl":"10.1080/13697137.2024.2368484","url":null,"abstract":"Objective: This study aimed to assess the possible association of adherence to the Mediterranean diet (MD) with muscle strength and body composition.Methods: The cross-sectional study evaluated 112 postmenopausal women (aged 41-71 years). Fasting blood samples were obtained for biochemical/hormonal assessment. The Mediterranean Dietary Score (MedDietScore) was calculated and used to stratify adherence by tertiles (low [T1], moderate [T2] or high [T3]). Handgrip strength (HGS) was measured by dynamometry and body composition with dual-X-ray absorptiometry.Results: Women with low-moderate MedDietScore (T1/T2) had lower HGS values than those with higher scores (19.5 ± 4.9 kg vs. 21.9 ± 3.9 kg, p = 0.023). A linear stepwise increase of HGS values per MedDietScore tertile was found (T1 vs. T2 vs. T3: 18.4 ± 4.4 kg vs. 20.6 ± 5.2 kg vs. 21.9 ± 3.9 kg, ANOVA p-value for linear trend = 0.009, ANCOVA p-value = 0.026). Multivariable models confirmed that HGS values were independently associated with the MedDietScore (β-coefficient = 0.266, p = 0.010). Lean mass values were associated with the MedDietScore (β-coefficient = 0.205, p = 0.040). All models were adjusted for age and cardiometabolic risk factors.Conclusions: The data suggest that the higher the adherence to the MD, the better the muscle strength and lean mass in postmenopausal women. Prospective studies are required to evaluate the significance of these observations in cardiovascular prevention strategies at midlife.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"382-388"},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141476038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

POESIT recommendations on management of body-identical hormones in menopausal symptoms. POESIT 关于更年期症状中体内同种激素管理的建议。

IF 2.9 4区医学

Climacteric Pub Date : 2024-08-01 Epub Date: 2024-07-08 DOI: 10.1080/13697137.2024.2368486

Santiago Palacios, Cláudio Rebelo, Ana Casquilho, Ana Rosa Costa, Angelo Cagnacci, Antonio Cano, Camil Castelo-Branco, Costantino Di Carlo, Fátima Romão, Fernanda Geraldes, Marco Gambacciani, Maria Fasero, Pluvio Coronado, Maria João Carvalho, Rossella E Nappi

{"title":"POESIT recommendations on management of body-identical hormones in menopausal symptoms.","authors":"Santiago Palacios, Cláudio Rebelo, Ana Casquilho, Ana Rosa Costa, Angelo Cagnacci, Antonio Cano, Camil Castelo-Branco, Costantino Di Carlo, Fátima Romão, Fernanda Geraldes, Marco Gambacciani, Maria Fasero, Pluvio Coronado, Maria João Carvalho, Rossella E Nappi","doi":"10.1080/13697137.2024.2368486","DOIUrl":"10.1080/13697137.2024.2368486","url":null,"abstract":"Many women seek treatment to improve menopausal vasomotor symptoms (VMS). The selection of women most likely to benefit from menopause hormone therapy (MHT) is crucial in clinical practice. There is general agreement that women younger than 60 years or who initiate MHT within the first 10 years of menopause, with no contraindications, have greater benefits considering symptomatic relief and additional advantages. This group may have the advantage of protection from osteoporosis and from other chronic diseases that affect postmenopausal women, namely cardiovascular disease (CVD). Cumulating evidence supports MHT for symptomatic women. However, inadequate use according to the needs of symptomatic women led to a burden of suffering worldwide. In recent years, the emergent use of non-regulated body-identical hormones (non-rBHT) can expose patients to potential harms. These hormone preparations are not regulated through the same tests of safety, efficacy or dosing consistency as regulated-BHT (r-BHT). The POESIT (Portugal + Spain + Italy) recommendations highlight the use of 17β-estradiol (E2) and micronized progesterone (P4) as the real r-BHT. In addition, the group emphasizes as an example the data from the REPLENISH study with 1 mg E2/100 mg P4. The combination of the two hormones in one convenient pill showed a clear reduction or elimination of hot flashes and an improvement in sleep quality and, consequently, quality of life. At the same time, this combination has shown high rates of amenorrhea and no significant impact on lipid, glucose or coagulation parameters. Both the REPLENISH study and a real-life retrospective study pointed to the possibility of a lower risk of venous thromboembolism (VTE) with this formulation than with other combinations.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"340-350"},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141558228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Real-world clinical evaluation of natural and induced vasomotor symptoms in the USA and Europe. 美国和欧洲对自然和诱发血管运动症状的真实世界临床评估。

IF 2.9 4区医学

Climacteric Pub Date : 2024-08-01 Epub Date: 2024-05-02 DOI: 10.1080/13697137.2024.2340472

Sheryl Kingsberg, Victoria Banks, Cecilia Caetano, Cecile Janssenswillen, Carsten Moeller, Nils Schoof, Lauren Lee, Megan Scott, Rossella E Nappi

{"title":"Real-world clinical evaluation of natural and induced vasomotor symptoms in the USA and Europe.","authors":"Sheryl Kingsberg, Victoria Banks, Cecilia Caetano, Cecile Janssenswillen, Carsten Moeller, Nils Schoof, Lauren Lee, Megan Scott, Rossella E Nappi","doi":"10.1080/13697137.2024.2340472","DOIUrl":"10.1080/13697137.2024.2340472","url":null,"abstract":"Objective: This study aimed to examine physicians' and patients' perceptions regarding symptom burden and impact in women experiencing natural vasomotor symptoms (nVMS) or vasomotor symptoms induced by endocrine therapy for breast cancer (iVMS).Methods: The cross-sectional survey based on real-world clinical consultations was conducted in the USA and five European countries. Obstetrician-gynecologists, primary-care physicians and oncologists provided demographic and symptom data for patients experiencing VMS; patients optionally self-reported their experiences via questionnaires, including their symptom profile and work/activity burden through the Menopause Quality of Life (MENQOL) and Work Productivity and Activity Impairment (WPAI) tools.Results: Physicians completed survey forms on 2451 consulting patients; patients completed 1029 questionnaires. nVMS and iVMS severity was significantly associated with the severity of mood symptoms and sleep disturbances (p < 0.0001). However, around half of the patients with mild nVMS/iVMS also experienced moderate-severe mood changes (55.4%/43.7%) or sleep disturbances (42.4%/40.4%). Presence of mood/sleep disturbances alongside nVMS increased MENQOL vasomotor scores (p = 0.004/p < 0.001). Presence of sleep disturbances increased WPAI activity impairment (p < 0.001) but mood changes did not. Similar findings were reported for iVMS patients.Conclusion: Significant burden from the triad of natural or induced menopausal symptoms, sleep disturbances and mood changes affected women's daily activities, work and quality of life more than vasomotor symptoms alone.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"364-372"},"PeriodicalIF":2.9,"publicationDate":"2024-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140857148","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0