Climacteric最新文献

{"title":"From waste to wellness - what women want: insights into patient perspectives on topical vaginal estrogen applicators and environmental considerations.","authors":"Ana Sofia Da Silva, Miriam O'Kane, Cathy Davis, Angie Rantell, George Araklitis, Dudley Robinson","doi":"10.1080/13697137.2025.2473431","DOIUrl":"https://doi.org/10.1080/13697137.2025.2473431","url":null,"abstract":"<p><strong>Objective: </strong>Environmental consciousness and the role of plastic waste are increasing. Topical vaginal estrogen prescription can be prescribed with one reusable plastic applicator or multiple single-use plastic applicators. User preference about the role of plastic in personal healthcare is not fully understood. This study aimed to explore patients' perspectives on the applicator and environmental considerations.</p><p><strong>Method: </strong>A mixed-methods questionnaire was employed to assess users' experience with topical vaginal estrogen applicators and their views on the environment.</p><p><strong>Results: </strong>Ninety-two respondents had previously used estriol 0.1% cream and 77 had used estradiol 10 μg vaginal inserts. The mean age of participants was 67.3 years. The mean duration of use was 36.5 months, and the discontinuation rate was 26.1% and 29.9% for estriol 0.1% cream and estradiol 10 μg vaginal insert users, respectively. Satisfaction with applicators and ease of use were similar in both groups. There was a higher report of the product being 'messy' (38.0% vs. 18.2%; <i>p</i> = 0.026) and 'not hygienic' (48.9% vs. 18.2%; <i>p</i> < 0.001) by estriol 0.1% cream users compared to estradiol 10 μg vaginal insert users. Women aged <65 years demonstrated a greater concern about plastic use and the impact on the environment compared to women aged over 65 years (81.0% vs. 56.9%; <i>p</i> = 0.002). The younger cohort showed a preference for reusable applicators (66.2%) compared to single-use applicators (33.8%) (<i>p =</i> 0.005). There was no statistically significant difference in preference for women aged over 65 years.</p><p><strong>Conclusion: </strong>This study demonstrates that younger postmenopausal women showed greater concern for plastic waste and its impact on the environment, with a preference for reusable products. Manufacturers of health products and prescribers should be aware of this growing trend. With similar overall satisfaction and side-effect profiles, users should be made aware of the different types of applicators available to help support an informed decision.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630233","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of multimorbidity patterns in perimenopausal women based on medical examination data.","authors":"Wenjun Luo, Jinning Mao, Shu Su, Meng Jia, Shili Xian, Jiaxian An, Xiaoya Qi, Lihong Mu","doi":"10.1080/13697137.2025.2470449","DOIUrl":"https://doi.org/10.1080/13697137.2025.2470449","url":null,"abstract":"<p><strong>Objective: </strong>The concurrent presence of multiple chronic diseases, termed multimorbidity, is increasingly prevalent among patients with chronic illnesses. This phenomenon is particularly pronounced in middle-aged women, yet has not received adequate attention. The objective of this study was to investigate the pattern of multimorbidity and its changes over time in perimenopausal women.</p><p><strong>Methods: </strong>A longitudinal study was conducted on the coexistence of chronic diseases in 3990 middle-aged women aged 40-65 years. The primary analytical tools were association rule mining and cross-lagged panel modeling, applied to the comprehensive medical examination data of the cohort.</p><p><strong>Result: </strong>At the first medical examination, 77.72% of participants were diagnosed with two or more chronic diseases, a figure that rose to 86.98% by the last examination. The most frequently observed multimorbidity combination pair under strong association rules is obesity and dyslipidemia. Additionally, the findings indicated that central obesity significantly influences lipid composition.</p><p><strong>Conclusion: </strong>This study highlights the elevated prevalence of multimorbidity in perimenopausal women and the added complexity of endocrine-related disorders at this life stage. There is an urgent need to develop personalized health management strategies for this demographic and to monitor and intervene in their health status in order to achieve healthy aging for perimenopausal women.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143575700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer reviewers for <i>Climacteric</i> in 2024.","authors":"","doi":"10.1080/13697137.2025.2459539","DOIUrl":"https://doi.org/10.1080/13697137.2025.2459539","url":null,"abstract":"","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-6"},"PeriodicalIF":2.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143540389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peer reviewers for <i>Climacteric</i> in 2024.","authors":"","doi":"10.1080/13697137.2025.2459539","DOIUrl":"https://doi.org/10.1080/13697137.2025.2459539","url":null,"abstract":"","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1"},"PeriodicalIF":2.9,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser for genitourinary syndrome of menopause: what we know and what we need to know.","authors":"Fiona G Li, Jason Abbott","doi":"10.1080/13697137.2025.2455186","DOIUrl":"10.1080/13697137.2025.2455186","url":null,"abstract":"<p><p>Energy-based treatments, including the fractional CO₂ laser, have been widely used for treatment of genitourinary symptoms associated with menopause. With the availability of data from seven double-blind sham-controlled randomized trials, the evidence does not support the fractional CO₂ laser as an efficacious treatment for genitourinary syndrome of menopause (GSM). A 2024 meta-analysis of these trials demonstrated that the symptom with greatest absolute improvement was dyspareunia at 16.3%, although not statistically significant. This improvement is far less than previously anticipated based on prospective data that suggested promising improvements of more than 90% satisfaction following laser treatment. Other data, including those from unblinded studies which are subject to a placebo effect, and outcomes that are not participant-reported including the appearance of the vagina on examination and histology, are not reliable in determining efficacy of laser treatment for GSM. While there may be a clinical effect of laser over sham treatments for GSM, the effect is unlikely to be clinically meaningful. Until we define and demonstrate a minimal clinically important difference in a robust and appropriately powered study, the laser should not be used in a clinical context for GSM.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-9"},"PeriodicalIF":2.9,"publicationDate":"2025-02-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143448431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Medical management of obesity: unlocking the potential.","authors":"Angie S Xiang, Priya Sumithran","doi":"10.1080/13697137.2025.2455177","DOIUrl":"10.1080/13697137.2025.2455177","url":null,"abstract":"<p><p>After a long and challenging history, there have finally been major breakthroughs in the development of effective obesity medications. Agents that act at receptors of one or more gut hormones are achieving unprecedented weight reductions and improvements in cardiovascular risk factors, comparable to some bariatric surgical procedures. Importantly, there is evidence of beneficial effects on a growing range of conditions, including type 2 diabetes, fatty liver, chronic kidney disease, obstructive sleep apnea and cardiovascular disease. Barriers to access need to be overcome to allow the standard of care for obesity to match that of other chronic diseases.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-5"},"PeriodicalIF":2.9,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363795","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the menopause journey.","authors":"Nanette Santoro","doi":"10.1080/13697137.2024.2445303","DOIUrl":"10.1080/13697137.2024.2445303","url":null,"abstract":"<p><p>The menopause experience is unique to people with ovaries who attain an age at which functioning follicles are depleted. Unlike male reproductive aging, menopause is accompanied by a definable reproductive milestone in that menstrual periods cease and the failure of follicle growth results in a large drop in circulating estrogen and no further ovarian production of progesterone. While the focus on menopause has largely been centered on this absence of hormone production, the most dynamic changes in symptoms and health markers begin before the final menstrual period, and merit attention. Vasomotor symptoms, the most common symptom of menopause and the primary symptom that drives women to seek treatment, peak in frequency and prevalence in the late menopause transition, when women are still having menstrual periods. Body composition and adverse lipoprotein and lipid changes also worsen most acutely in the late transition, and then assume a slower, age-related trajectory of change. Multiple processes that worsen across the transition restabilize after it is over. The notion that the menopause transition is an adaptive process for women has scientific merit and suggests that facilitating this adaptation and recognizing its implications may represent the next phase of progress in the field.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-5"},"PeriodicalIF":2.9,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corneal thickness, contrast sensitivity and binocular vision in menopausal and non-menopausal women.","authors":"Hemn Baghban Jaldian, Ali Mirzajani, Rasoul Amini Vishteh, Jamileh Abolghasemi, Parva Pourbagherkhah","doi":"10.1080/13697137.2024.2438733","DOIUrl":"10.1080/13697137.2024.2438733","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to investigate the effects of menopause on ocular health and visual function.</p><p><strong>Method: </strong>Sixty-two women (31 premenopausal and 31 postmenopausal) who visited Rasht Health Center were selected and matched based on their ages and compared in terms of their hormonal status, central corneal thickness (CCT), contrast sensitivity (CS), binocular vision variables and refractive error.</p><p><strong>Results: </strong>CCT and corneal curvature were significantly thinner in postmenopausal women. However, menopause had no significant impact on CS, binocular vision or refractive error.</p><p><strong>Conclusion: </strong>Age-related hormonal abnormalities play a significant role in corneal thinning, highlighting the intricate relationship between systemic hormonal changes and ocular health. In contrast, binocular vision functions remain unaffected by menopause.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"69-73"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142846074","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Monique Boulet: 30 March 1938 - 26 March 2024.","authors":"Tim Hillard, Wulf Utian, Hermann Schneider","doi":"10.1080/13697137.2024.2436832","DOIUrl":"https://doi.org/10.1080/13697137.2024.2436832","url":null,"abstract":"","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":"28 1","pages":"93-94"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143064125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cut-off point development for the Everyday Memory Questionnaire - Revised in perimenopausal women.","authors":"Chen Zhu, Elizabeth H X Thomas, Qi Li, Shalini Arunogiri, Caroline Gurvich","doi":"10.1080/13697137.2024.2401369","DOIUrl":"10.1080/13697137.2024.2401369","url":null,"abstract":"<p><strong>Objective: </strong>Subjective cognitive complaints have been reported in women during perimenopause and the Everyday Memory Questionnaire - Revised (EMQ-R) has been recently evaluated as a standardized instrument to measure subjective cognitive changes. The purpose of this study was to identify potential cut-off points for the EMQ-R retrieval subscale and attentional subscale, and to assess the validity of these cut-off points in detecting objective cognitive changes associated with reported subjective cognitive complaints.</p><p><strong>Method: </strong>After screening, 232 perimenopausal women were included in the analyses. The supervised classification and regression tree was applied to identify optimal cut-off points. Its performance was evaluated by the value of the receiver operating characteristics curve, sensitivity and specificity.</p><p><strong>Results: </strong>Findings revealed that the optimal cut-off point for the attentional subscale was 7, and for the retrieval subscale was 13. Both cut-off points presented acceptable discrimination performance. An independent <i>t</i>-test indicated that both cut-off points were associated with significant differences in scores on neuropsychological measures of retrieval (episodic memory and verbal fluency) as well as neuropsychological measures of higher-level attention (working memory).</p><p><strong>Conclusion: </strong>The identified cut-off points may be helpful for women to track or quantify their subjective experiences of brain fog or cognitive symptoms during the menopause transition.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"51-60"},"PeriodicalIF":2.9,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}