Effect of menopause hormone therapy and serotonin reuptake inhibitors.

IF 2.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY

Climacteric Pub Date : 2025-05-01 DOI:10.1080/13697137.2025.2486051

Natalia Pereira de Oliveira, Luciano de Melo Pompei

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引用次数: 0

Abstract

Objective: Postmenopausal hypoestrogenism may cause significant changes in the oral cavity, interfering with inflammatory mechanisms such as salivary secretion. This study aimed to compare the salivary flow, pH levels and prevalence of dry mouth in postmenopausal women treated with hormone replacement therapy (HRT), those treated with selective serotonin reuptake inhibitors (SSRIs) and those without treatment.

Methods: Ninety postmenopausal women participated in the study. Of these, 30 used HRT, 30 used SSRIs and 30 did not receive any treatment (control). Salivary flow was measured using stimulated sialometry, while the pH level was measured using pH strips. Meanwhile, a questionnaire was used to assess for xerostomia.

Results: The salivary flow measurements were 1.66 ± 0.49 ml/min for the HRT group, 1.23 ± 0.50 ml/min for the SSRI group and 1.68 ± 0.65 ml/min for the control group (p = 0.005 for comparison). The pH values were 7.13 ± 0.43, 7.0 ± 0.26 and 6.97 ± 0.41 for the HRT, SSRI and control groups, respectively. Xerostomia was reported in 60% of women receiving HRT, 46.7% receiving SSRIs and 26.7% of the controls (p = 0.033).

Conclusion: Women using SSRIs had lower salivary flow than the HRT or control group. However, xerostomia was more prevalent in women receiving HRT.

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更年期激素治疗和血清素再摄取抑制剂的效果。

目的：绝经后雌激素水平降低可能导致口腔发生明显变化，干扰唾液分泌等炎症机制。本研究旨在比较接受激素替代疗法（HRT）、选择性血清素再摄取抑制剂（SSRIs）和未接受治疗的绝经后妇女的唾液流量、pH值和口干发生率。方法：90名绝经后妇女参与研究。其中30人使用HRT， 30人使用SSRIs， 30人未接受任何治疗（对照组）。用刺激唾液法测定唾液流量，用pH条测定pH值。同时，使用问卷评估口干症。结果：HRT组唾液流量为1.66±0.49 ml/min， SSRI组为1.23±0.50 ml/min，对照组为1.68±0.65 ml/min （p = 0.005）。HRT组、SSRI组和对照组的pH值分别为7.13±0.43、7.0±0.26和6.97±0.41。接受HRT治疗的女性中有60%出现口干，接受SSRIs治疗的女性为46.7%，对照组为26.7% （p = 0.033）。结论：使用ssri类药物的女性唾液流量低于HRT或对照组。然而，口干症在接受激素替代疗法的女性中更为普遍。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.