Climacteric最新文献

{"title":"The association between smoking and joint pain in women attending a specialized menopause clinic.","authors":"Taylor Roebotham, Farhad Ghasemi, Wendy Wolfman","doi":"10.1080/13697137.2026.2628339","DOIUrl":"10.1080/13697137.2026.2628339","url":null,"abstract":"<p><strong>Objective: </strong>Joint pain is a common menopausal symptom, but remains poorly understood. Smoking has an anti-estrogenic effect and is linked to pain syndromes. This study evaluated whether smoking is independently associated with joint pain in menopausal women.</p><p><strong>Method: </strong>This study was a cross-sectional analysis of survey data from 371 menopausal women attending a Canadian menopause clinic (2017-2019). Participants self-reported symptom severity, medical history and lifestyle factors. Moderate to severe joint pain was defined as a symptom score ≥2 on a 5-point scale. Logistic regression assessed associations between smoking and joint pain, adjusting for age, estrogen use, alcohol consumption, obesity and depression.</p><p><strong>Results: </strong>Moderate to severe joint pain was reported by 52% of participants. Smoking was significantly associated with joint pain in both univariate (odds ratio [OR] 2.32, 95% confidence interval [CI]: 1.15-5.03) and multivariate (OR 2.18, 95% CI: 1.05-4.82) models. Joint pain was also associated with hot flashes, mood symptoms and fatigue. Age, estrogen use, obesity, depression, alcohol use and sexual activity were not significantly associated.</p><p><strong>Conclusion: </strong>Smoking is independently associated with joint pain in menopausal women. While the underlying mechanisms remain unclear, this association supports the hypothesis that estrogen-related pathways play a role in menopausal joint symptoms and highlights smoking as a potential modifiable risk factor.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"544-550"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147347584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Commentary on intermittent walking training and thyroid function in postmenopausal women.","authors":"Jiayi Chen","doi":"10.1080/13697137.2026.2664748","DOIUrl":"10.1080/13697137.2026.2664748","url":null,"abstract":"","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"642"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147947909","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The International Menopause Society celebrates another milestone.","authors":"Antonio Cano, Steve R Goldstein, Maria Celeste O Wender, Santiago Palacios","doi":"10.1080/13697137.2026.2694910","DOIUrl":"10.1080/13697137.2026.2694910","url":null,"abstract":"","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"485-486"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148359639","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The effect of auricular acupressure on quality of life in postmenopausal women: a randomized sham-controlled clinical trial.","authors":"Zainab Alimoradi, Zohreh Hosseini Marznaki, Amirnavid Moeini","doi":"10.1080/13697137.2026.2645641","DOIUrl":"10.1080/13697137.2026.2645641","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;With the decline in the average age of menopause, increased life expectancy and rising longevity among women, a significant number face menopausal challenges including physical and psychological symptoms that adversely affect their quality of life (QoL). Given the growing preference for complementary therapies over menopausal hormone therapy (MHT) and promising evidence on auricular acupressure, this study aimed to investigate its effect on QoL in postmenopausal women.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Method: &lt;/strong&gt;The randomized sham-controlled clinical trial enrolled 120 eligible postmenopausal women visiting comprehensive health centers in Qazvin, Iran, between February and August 2024. Participants were randomized into intervention (&lt;i&gt;n&lt;/i&gt; = 60) or sham (&lt;i&gt;n&lt;/i&gt; = 60) groups using the balanced blocks randomization method. The intervention group received auricular acupressure using Vaccaria seed-embedded tapes on specific points (Chinese/European uterine, ovary, Shenmen, brain, gonadotropin and sympathetic points) over 10 sessions (4-day intervals). Participants were instructed to apply moderate pressure to each point for 20 s, three times daily. The sham group followed an identical protocol but used non-seeded tapes. Data were collected using demographic/fertility questionnaires and the Menopause-Specific Quality of Life Questionnaire (MENQOL), assessing vasomotor, physical, psychosocial and sexual domains (lower scores indicate improved QoL). QoL was evaluated at baseline, 1 month post intervention and 2 months post intervention. Data were analyzed using repeated-measures analysis of variance-analysis of covariance (SPSS version 27, &lt;i&gt;α&lt;/i&gt; = 0.05).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;Baseline QoL scores did not differ significantly between groups. Post intervention, the intervention group showed statistically significant reductions in total QoL scores and all subscales at 1-month and 2-month follow-ups (&lt;i&gt;p&lt;/i&gt; &lt; 0.05). Mean differences for intervention versus sham groups in the first and second follow-ups were -28.50, -48.87 for total QoL; -2.36, -5.92 for vasomotor subscale; -2.55, -9.75 for psychosocial subscale; -10.89, -28.41 for physical subscale; and -1.62, -4.78 for sexual subscale. Based on &lt;i&gt;η&lt;/i&gt;&lt;sup&gt;2&lt;/sup&gt;-values, auricular acupressure explained 63.4% of total QoL variance, and 61.6% (vasomotor), 39.9% (psychosocial), 66.2% (physical), and 42.4% (sexual) for the subscales.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Conclusion: &lt;/strong&gt;Auricular acupressure significantly improved overall QoL and all specific domains (physical, psychosocial, vasomotor, sexual) in postmenopausal women. Healthcare providers may consider this non-pharmacological therapy particularly for MHT-ineligible patients to alleviate menopausal symptoms and enhance QoL. Some limitations such as potential social desirability bias from self-reported measures, the lack of objective biomarkers due to budget limits and unevaluated confounding factors related to living conditi","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"586-599"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147834361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Perimenopausal migraine: a narrative review.","authors":"Salwa Kamourieh, E Anne MacGregor","doi":"10.1080/13697137.2026.2675559","DOIUrl":"10.1080/13697137.2026.2675559","url":null,"abstract":"<p><p>Migraine is a highly prevalent primary headache disorder that disproportionately affects women owing to the effects of sex hormones, particularly estrogen. Hyperestrogenism during early perimenopause, coupled with anovulatory cycles, is associated with an increased frequency and severity of migraine attacks and an increased prevalence of perimenstrual migraine. The natural decline in estrogen levels after menopause is generally associated with migraine improvement; however, this is variable and often complicated by chronic migraine, vasomotor symptoms, cardiovascular risk and use of menopause hormone therapy (MHT). Although there is a trend toward increasing the use of MHT during perimenopause, there are no research trials regarding migraine in this population, although it appears to have a negative clinical effect. This could be explained by the addition of MHT to the already high and fluctuating endogenous estrogen levels. More appropriate during perimenopause is hormone cycle control. This can be achieved using continuous combined hormonal contraception for women with migraine without aura, whereas progestogen-only regimens, with the option of additional transdermal estrogen, can be used in women with migraine with and without aura. For women choosing to use MHT postmenopause, continuous transdermal regimens are better tolerated than cyclical preparations.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"507-515"},"PeriodicalIF":3.9,"publicationDate":"2026-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148216202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menarche, menopause and reproductive span in relation to frailty trajectories in Chinese women.","authors":"Cui-E Li, Yong-Yong Liu, Yu-Xuan Zhang, Bin-Bin Feng, Lin Zhu, Ruo-Wei Ma, Guo-Cui Wu","doi":"10.1080/13697137.2025.2601009","DOIUrl":"10.1080/13697137.2025.2601009","url":null,"abstract":"<p><strong>Objective: </strong>Frailty is a dynamic condition, but the influence of female reproductive factors on its long-term trajectories remains unclear. This study aimed to examine whether age at menarche (AAM), age at menopause (AMP) and reproductive span (RS) predict long-term frailty trajectories in middle-aged and older women.</p><p><strong>Method: </strong>Data were analyzed from four waves (2011-2018) of the China Health and Retirement Longitudinal Study (CHARLS). Frailty was measured using the frailty index (FI), and trajectories were identified via latent category growth modeling (LCGM). Logistic regression and restricted cubic spline analyses assessed the associations of reproductive factors with FI trajectories.</p><p><strong>Results: </strong>Among 2775 women, FI trajectories were classified into two groups: 'low-stable' (<i>N</i> = 1961) and 'high-rising' (<i>N</i> = 814). Compared with women who had menopause at ages 46-54 years, those with AMP ≤45 years (odds ratio [OR] = 1.377, 95% confidence interval [CI]: 1.073-1.766) or AMP ≥55 years (OR = 1.558, 95% CI: 1.113-2.181) had higher odds of following the 'high-rising' frailty trajectory. Similarly, RS < 26 years (OR = 1.810, 95% CI: 1.277-2.566) or RS ≥40 years (OR = 1.734, 95% CI: 1.123-2.678) were associated with increased odds of the 'high-rising' trajectory. AAM was not significantly associated with frailty trajectories.</p><p><strong>Conclusions: </strong>Early or late menopause and extreme RS are associated with worsening frailty trajectories.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"445-454"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145910526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endometriosis beyond menopause: a call for greater clinical awareness.","authors":"Shant Apelian, Peter Chedraui, Hugh S Taylor","doi":"10.1080/13697137.2026.2658790","DOIUrl":"10.1080/13697137.2026.2658790","url":null,"abstract":"","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"324-326"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147764134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Single nucleotide variants in <i>VDR</i> and <i>GC</i> genes associated with osteoporosis in Mexican women.","authors":"Rosalba Sevilla-Montoya, María Eugenia Flores-Quijano, Mari Cruz Tolentino-Dolores, Yuridia Martínez-Meza, Guillermo Federico Ortiz-Luna, Angélica Castañeda-de-la-Fuente, Larissa López-Rodriguez, Gerardo Rodríguez-González, Luis Felipe León-Madero, Héctor Borboa-Olivares, Rafael Velázquez-Cruz, Liliana Fernández-Hernández, Alberto Hidalgo-Bravo","doi":"10.1080/13697137.2025.2584063","DOIUrl":"10.1080/13697137.2025.2584063","url":null,"abstract":"<p><strong>Objective: </strong>Osteoporosis is a prevalent multifactorial disease. Single nucleotide variants (SNVs) have been studied as a potential tool for estimating disease risk. These findings suggest that the GG genotype of rs2282679 in the vitamin D-binding protein (<i>GC</i>) gene may confer a protective effect against osteoporosis in postmenopausal Mexican women, whereas no significant association was found for rs4516035 in the vitamin D receptor (VDR). This highlights the potential of integrating genetic screening, particularly of GC-related variants, into osteoporosis risk assessment and prevention strategies.</p><p><strong>Method: </strong>A total of 535 women were included. Genotyping was performed through TaqMan assays, and association analyses, including the chi-squared test and logistic regression, were conducted considering different inheritance models.</p><p><strong>Results: </strong>The allelic frequencies from both SNVs did not show a statistically significant difference between the groups of cases and controls. However, through logistic regression analyses for rs2282679, the GG genotype of the rs2282679 was associated with a protective effect under both recessive and additive inheritance models in unadjusted (odds ratio [OR] 0.27, confidence interval [CI] 0.11-0.63, <i>p</i> = 0.003; OR 0.26, CI 0.11-0.63, <i>p</i> = 0.003, respectively) and adjusted (OR 0.13, CI 0.03-0.55, <i>p</i> = 0.006; OR 0.13, CI 0.03-0.57, <i>p</i> = 0.007, respectively) models.</p><p><strong>Conclusion: </strong>The GG genotype of rs2282679 seems to confer protection against osteoporosis. Further research, including functional validation and studies in larger and diverse cohorts, is warranted to elucidate the underlying biological mechanisms and confirm these results.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"396-401"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145741118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hot flashes: a potential marker of deterioration of health-related quality of life.","authors":"Juan E Blümel, María S Vallejo, Peter Chedraui, Eugenio Arteaga, Félix Ayala, Ascanio Bencosme, Andrés Calle, Lucia Costa-Paiva, Maribel Dextre, Karen Díaz, Alejandra Elizalde-Cremonte, Santiago Elizalde-Cremonte, Carlos Escalante, María T Espinoza, Ircania García, Gustavo Gómez-Tabares, Hugo Gutiérrez-Crespo, Marcela López, Juan Matsumura-Kasana, Paolo Meza, Álvaro Monterrosa-Castro, Mónica Ñañez, Eliana Ojeda, Claudia Rey, Ana Lucia Ribeiro Valadares, Doris Rodríguez-Vidal, Marcio Ah Rodrigues, Javier Saavedra, Carlos Salinas, Lida Sosa, Konstantinos Tserotas, Margot Acuña-San Martín, Marcela S Aguirre","doi":"10.1080/13697137.2026.2627561","DOIUrl":"10.1080/13697137.2026.2627561","url":null,"abstract":"<p><strong>Objective: </strong>Hot flashes are among the most common symptoms of the menopausal transition and have traditionally been considered benign and self-limiting. However, increasing evidence suggests that they may indicate broader neurovascular and inflammatory dysregulation linked to reproductive aging. The possible effect of hot flush severity on health-related quality of life (HRQoL) remains inadequately studied, particularly in Latin American populations. This study aimed to examine the association between hot flash severity and HRQoL in middle-aged women using validated tools and a large, multicenter sample.</p><p><strong>Method: </strong>A cross-sectional study was conducted between June 2024 and January 2025 in 30 healthcare centers across 12 Latin American countries. A total of 3523 women aged 40-60 years were assessed using the Menopause Rating Scale (MRS) to evaluate vasomotor symptoms and the Short Form-36 Health Survey (SF-36) to measure HRQoL. Multivariable logistic regression models were utilized to estimate the association between hot flush severity and low HRQoL, adjusting for sociodemographic, behavioral and clinical covariates.</p><p><strong>Results: </strong>Increasing severity of hot flushes was significantly associated with lower HRQoL scores across all SF-36 domains. In the logistic regression analysis, mild hot flushes (MRS item 1 score = 1) were associated with increased odds of impaired HRQoL (odds ratio [OR] 1.29; 95% confidence interval [CI]: 1.08-1.55), whereas very severe symptoms (MRS item 1 score = 4) demonstrated a substantially stronger association (OR 4.10; 95% CI: 2.93-5.74). Additional factors significantly associated with lower HRQoL included physical inactivity, the presence of comorbidities, obesity, current use of psychotropic medication, age ≥50 years and having two or more children.</p><p><strong>Conclusion: </strong>Hot flush severity is a strong and independent determinant of HRQoL in midlife women. These findings underscore the need for systematic assessment and targeted management of vasomotor symptoms in routine care, supporting the hypothesis that hot flashes may be a clinical marker of systemic aging.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"462-469"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147269774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reproductive potential in mosaic Turner syndrome: impact of karyotype pattern and mosaicism ratio.","authors":"Yun Cheng, Hsin-Hsin Cheng, Chen-Hao Lee, Kun-Long Huang, Yu-Ju Lin, Te-Yao Hsu, Kuo-Chung Lan","doi":"10.1080/13697137.2026.2631499","DOIUrl":"10.1080/13697137.2026.2631499","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate reproductive potential in women with Turner syndrome (TS), focusing on 45,X/46,XX mosaicism and the impact of mosaic ratio on reproductive outcomes.</p><p><strong>Method: </strong>The study retrospectively analyzed 145 TS patients diagnosed postnatally by peripheral blood karyotyping from January 1990 to May 2023. Karyotypes were categorized into 45,X monosomy, 45,X mosaicism with Y chromosome and 45,X mosaicism without Y chromosome.</p><p><strong>Results: </strong>The predominant karyotype was 45,X/46,XX mosaicism (71.0%), accounting for most cases with preserved reproductive potential. Within this subgroup, spontaneous menarche (SM) occurred in 97.7% of cases with <40% 45,X cells, while 84.2% of pregnancies occurred in those with <10% 45,X cells. Among patients aged ≥15 years with mosaic karyotypes containing 46,XX and no structural abnormalities, SM occurred in 95.3% of those with <40% 45,X cells, but in none with ≥40% (<i>p</i> < 0.001). In contrast, cases of 45,X monosomy, Y-containing mosaicism, structural X abnormalities, 45,X/46,X with marker chromosomes or 45,X/47,XXX showed no pregnancies and minimal SM. Recurrent pregnancy loss (RPL) was the diagnostic indication in 34% of cases, likely enriching milder mosaicism.</p><p><strong>Conclusions: </strong>Women with 45,X/46,XX mosaicism retain reproductive potential, particularly when 45,X cell ratios are low. Early diagnosis via peripheral blood karyotyping supports timely fertility counseling and ovarian care.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"455-461"},"PeriodicalIF":3.9,"publicationDate":"2026-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147430966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}