Climacteric最新文献_第7页

Treating VVA improves symptom severity and patient-reported outcomes: 6-month PEONY results. 治疗VVA可改善症状严重程度和患者报告的结果：6个月的牡丹结果。

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2025-02-07 DOI: 10.1080/13697137.2025.2455167

Rossella E Nappi, Maria Cristina Meriggiola, Francesca Albani, Gloria Bonaccorsi, Giovanni Delli Carpini, Alessandro Gambera, Silvia Marsini, Antonio Nicolucci, Maria Chiara Rossi, Valentina Trionfera, Paola Villa

{"title":"Treating VVA improves symptom severity and patient-reported outcomes: 6-month PEONY results.","authors":"Rossella E Nappi, Maria Cristina Meriggiola, Francesca Albani, Gloria Bonaccorsi, Giovanni Delli Carpini, Alessandro Gambera, Silvia Marsini, Antonio Nicolucci, Maria Chiara Rossi, Valentina Trionfera, Paola Villa","doi":"10.1080/13697137.2025.2455167","DOIUrl":"10.1080/13697137.2025.2455167","url":null,"abstract":"Objective: The real-world PatiEnt satisfactiON studY (PEONY) involves postmenopausal women already treated or starting local estrogen therapy (LET) or ospemifene. The aim of the present analysis was to assess treatment satisfaction and persistence, effectiveness and patient-reported outcomes (PROs) in sexual function and quality of life after 6 months of therapy with LET or ospemifene to treat vulvovaginal atrophy (VVA).Methods: PEONY is an ongoing prospective, observational study conducted in 17 gynecology centers. Participants complete questionnaires at baseline (T0) and after 3 months (T3) and 6 months (T6). The main outcome measures were treatment satisfaction, severity of symptoms, Day-to-Day Impact of Vaginal Aging (DIVA), Female Sexual Function Index (FSFI), Female Sexual Distress Scale - Revised (FSDS-R) and SF-12 Health Survey.Results: Overall, 385 women were included, of whom 145 started (87.6%) or continued (12.4%) ospemifene and 240 started (66.7%) or continued (33.3%) LET at T0. The likelihood of moderate/severe VVA symptoms decreased by 70-90% and the mean treatment satisfaction score increased overall from 7.3 (95% confidence interval [CI]: 7.0; 7.5) at T3 to 7.7 (95% CI: 7.4; 7.9) at T6 (p = 0.003). DIVA and FSDS-R scores significantly improved in both groups.Conclusions: PEONY underlines the importance of proactively treating VVA with LET or ospemifene to alleviate the burden associated with the disease.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"115-125"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Flaxseed and mulberry extract improve trabecular bone quality in estrogen-deficient rats. 亚麻籽和桑葚提取物改善雌激素缺乏大鼠骨小梁质量。

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2025-02-12 DOI: 10.1080/13697137.2025.2457988

Larissa Sampaio Jacques, Jéssica Petrine Castro Pereira, Beatriz Menegate Santos, Breno Rocha Barrioni, Bruno Del Bianco Borges

{"title":"Flaxseed and mulberry extract improve trabecular bone quality in estrogen-deficient rats.","authors":"Larissa Sampaio Jacques, Jéssica Petrine Castro Pereira, Beatriz Menegate Santos, Breno Rocha Barrioni, Bruno Del Bianco Borges","doi":"10.1080/13697137.2025.2457988","DOIUrl":"10.1080/13697137.2025.2457988","url":null,"abstract":"Many hormones, including estrogens, modulate bone metabolism, which plays a crucial role in maintaining bone health. Estrogen depletion, as occurs in menopause, leads to increased bone resorption and decreased formation, resulting in osteopenia/osteoporosis. This study investigates the effects of flaxseed (Linum usitatissimum) and mulberry (Morus nigra L.) extracts, known for their phenolic compounds and antioxidant properties, against estrogen deficiency-induced bone loss in female Wistar rats. These extracts were administered to ovariectomized rats for 60 days. High-performance liquid chromatography analysis revealed the presence of some phenolic compounds in the extracts, including trigonelline, gallic acid, theobromine, chlorogenic acid, syringic acid and p-coumaric acid. The extracts improved bone microstructure with higher trabecular bone, bone mineral density, calcium, phosphorus and magnesium levels, and lower porosity and intertrabecular space in bone tissue. Furthermore, plasma alkaline phosphatase activity was elevated in extract-treated animals, indicating enhanced bone tissue formation. Although serum carboxy-terminal fragment levels showed no significant change, the data suggest that flaxseed and mulberry extracts may protect against trabecular bone loss and support bone formation in estrogen-deficient conditions. These results suggest that supplementing these natural extracts holds promise in preventing or alleviating the signs and symptoms associated with estrogenic deficiency.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"175-183"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143398506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Relationship between insulin resistance surrogates and bone mineral density in postmenopausal women. 绝经后妇女胰岛素抵抗替代物与骨密度的关系。

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2025-02-04 DOI: 10.1080/13697137.2025.2455164

Min Li, Lei Gao, Ying Liu, Yongli Zheng, Luyao Chen, Yan Wang, Wei Zhang

{"title":"Relationship between insulin resistance surrogates and bone mineral density in postmenopausal women.","authors":"Min Li, Lei Gao, Ying Liu, Yongli Zheng, Luyao Chen, Yan Wang, Wei Zhang","doi":"10.1080/13697137.2025.2455164","DOIUrl":"10.1080/13697137.2025.2455164","url":null,"abstract":"Objective: This study aimed to investigate the association between four insulin resistance (IR) surrogates and bone mineral density (BMD) and whether IR surrogates could be risk factors for osteoporosis (OP) in Chinese non-diabetic postmenopausal individuals.Methods: Four non-insulin-based surrogates including triglyceride glucose (TyG), triglyceride glucose with body mass index (TyG-BMI), triglycerides (TG)/high-density lipoprotein cholesterol (HDL-C) and the metabolic score for insulin resistance (METS-IR) index were calculated. All individuals underwent dual-energy X-ray absorptiometry for measurement of BMD. Pearson correlation analysis was employed to evaluate the correlations between IR indices and BMD. Subsequently, logistic regression analysis was performed to investigate the relationship between these indices and OP while the receiver-operating characteristic curve was used to assess the predictive values for OP.Results: Both TyG-BMI and the METS-IR index were significantly positively associated with BMD. As TyG-BMI and the METS-IR index increased, the prevalence of OP decreased. After adjusting confounding factors, the fourth quartile of TyG-BMI and the METS-IR index showed significantly decreased odds ratio of 0.304 and 0.352, respectively, for OP with respect to its first quartile value. The area under the curve of TyG-BMI and the METS-IR index was 0.616 and 0.605, respectively.Conclusions: IR surrogates TyG-BMI and the METS-IR index were positively associated with BMD and may be protective factors for OP in Chinese non-diabetic postmenopausal women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"154-161"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Influence of estradiol deficiency on the mineralocorticoid receptor response in postmenopausal women: a cross-sectional study. 雌二醇缺乏对绝经后妇女矿皮质激素受体反应的影响：一项横断面研究

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2025-02-10 DOI: 10.1080/13697137.2025.2455181

Alejandra Martínez-García, Jorge A Pérez, Alejandra Tapia-Castillo, María P Hernández, Marlin Solórzano, Pablo Carrión, Carlos E Fardella, Cristian A Carvajal

{"title":"Influence of estradiol deficiency on the mineralocorticoid receptor response in postmenopausal women: a cross-sectional study.","authors":"Alejandra Martínez-García, Jorge A Pérez, Alejandra Tapia-Castillo, María P Hernández, Marlin Solórzano, Pablo Carrión, Carlos E Fardella, Cristian A Carvajal","doi":"10.1080/13697137.2025.2455181","DOIUrl":"10.1080/13697137.2025.2455181","url":null,"abstract":"Objective: Premenopausal women (PreM) have a cardioprotective advantage over postmenopausal women (PostM) due to estrogen. The interaction of estrogen with the mineralocorticoid receptor (MR) pathway remains unexplored. This study aimed to identify changes in aldosterone, renin and sexual steroid levels and MR surrogate biomarkers in PostM that may explain changes in blood pressure and renal damage.Methods: A cross-sectional study was carried out with 47 normotensive and hypertensive Chilean women distributed between PreM and PostM. Clinical, anthropometric and biochemical parameters, including aldosterone, plasma renin activity (PRA) and surrogate markers of MR activity, were assessed.Results: PostM had greater systolic blood pressure (SBP) (p < 0.001) than PreM. A negative correlation was observed between estradiol and fractional excretion of potassium (FEK) (ρ = -0.29; p = 0.023), adjusted for age and SBP. Compared with hypertensive PreM, hypertensive PostM (PostM-HT) showed reduced PRA (p = 0.045) and greater FEK (p = 0.04). Normotensive PostM (Post-NT) exhibited greater SBP (p = 0.03), neutrophil gelatinase-associated lipocalin (NGAL) levels (p = 0.04) and FEK (p = 0.03) than normotensive PreM.Conclusion: Our results suggest enhanced MR sensitivity not only in PostM-HT, as evidenced by lower PRA and elevated FEK, but also in PostM-NT, who exhibited greater FEK and NGAL levels, surrogate markers of MR activation. These results support a novel role of MR activation and cardiovascular risk in PostM women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"162-168"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381649","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concentration and genetic regulation of sex hormone binding globulin and fracture risk in older women. 性激素结合球蛋白的浓度和基因调控与老年妇女骨折风险。

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2024-12-05 DOI: 10.1080/13697137.2024.2431036

Yuanyuan Wang, Chenglong Yu, Rakibul M Islam, Sultana Monira Hussain, Anna L Barker, Paul Lacaze, John J McNeil, Susan R Davis

{"title":"Concentration and genetic regulation of sex hormone binding globulin and fracture risk in older women.","authors":"Yuanyuan Wang, Chenglong Yu, Rakibul M Islam, Sultana Monira Hussain, Anna L Barker, Paul Lacaze, John J McNeil, Susan R Davis","doi":"10.1080/13697137.2024.2431036","DOIUrl":"10.1080/13697137.2024.2431036","url":null,"abstract":"Objective: This study aimed to examine the association between concentrations of sex hormone binding globulin (SHBG) and fracture risk in community-dwelling older women and explore whether this was explained by the genetic regulation of SHBG.Methods: This prospective cohort study examined 4871 women aged ≥70 years who were not taking medications influencing SHBG concentrations. A genome-wide association study was undertaken to identify single nucleotide polymorphisms (SNPs) associated with SHBG concentrations. Incident fracture was confirmed by medical imaging and adjudicated by expert review committee.Results: The median age of participants was 74.0 years. Over 3.9 (standard deviation 1.4) years of follow-up, 484 participants had an incident fracture. There was a linear trend for a positive association between SHBG concentrations and fracture risk (p = 0.001), with the highest SHBG quartile associated with a significantly greater fracture risk compared with the lowest quartile (hazard ratio 1.54, 95% confidence interval 1.16-2.04, p = 0.003), adjusting for age, body mass index, alcohol consumption, smoking, diabetes, impaired renal function, treatment allocation, medications affecting bone and high-density lipoprotein cholesterol. Two independent SNPs were associated with SHBG concentrations, rs10822163 and rs727428, but neither was associated with fracture risk.Conclusion: SHBG concentrations were positively associated with a greater fracture risk in community-dwelling women aged ≥70 years, which was not explained by genetic variants associated with SHBG regulation.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"184-190"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11949721/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142784316","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intravenous administration of mitochondria improves ovarian function by anti-apoptosis in the premature ovarian insufficiency model. 在卵巢功能不全模型中，静脉给药线粒体通过抗细胞凋亡改善卵巢功能。

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2025-01-10 DOI: 10.1080/13697137.2024.2441248

Han-Lin Yang, Yuan-Mei Wang, Qing Li, Hao Luo, Jun Tan, Xing Zhao, Dan Zi

{"title":"Intravenous administration of mitochondria improves ovarian function by anti-apoptosis in the premature ovarian insufficiency model.","authors":"Han-Lin Yang, Yuan-Mei Wang, Qing Li, Hao Luo, Jun Tan, Xing Zhao, Dan Zi","doi":"10.1080/13697137.2024.2441248","DOIUrl":"10.1080/13697137.2024.2441248","url":null,"abstract":"Objective: For patients with contraindications to hormone therapy, the absence of effective treatments for ovarian dysfunction post chemotherapy represents a critical issue requiring resolution. Local administration of mitochondria may enhance ovarian function in premature ovarian insufficiency (POI) by ameliorating diminished mitochondrial activity. Nevertheless, there is a paucity of literature on the efficacy of mitochondrial transplantation through intravenous injection, a less invasive and more convenient method than local injection, for the improvement of ovarian function in POI following chemotherapy.Method: Mitochondria were isolated from mouse livers, their activity and integrity were validated with MitoTracker Red and their localization was examined via confocal microscopy, real-time quantitative PCR and enzyme-linked immunosorbent assay post tail vein injection. An ovarian insufficiency animal model induced by chemotherapy was developed, and ovarian function was assessed through ovarian diameter, vaginal smear, body weight, sex hormone levels and histological analysis. The impact of mitochondrial transplantation on an ovarian cell model was examined through the assessment of mitochondrial function, apoptosis and levels of reactive oxygen species.Conclusion: Tail vein injection of isolated mitochondria has the potential to enhance ovarian functions in an animal model of POI induced by cyclophosphamide, increase mitochondrial activity in impaired ovarian cells and decrease the rate of apoptosis.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"200-211"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142944931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of ovarian aging on muscle strength and life quality in various reproductive aging stages. 卵巢衰老对生殖衰老各阶段肌力及生活质量的影响。

IF 2.9 4区医学

Climacteric Pub Date : 2025-03-20 DOI: 10.1080/13697137.2025.2470451

Aiyue Luo, Hongyu Li, Xing Lv, Peizhe Zheng, Kehan Lin, Aiting Liang, Shuhong Yang

{"title":"The impact of ovarian aging on muscle strength and life quality in various reproductive aging stages.","authors":"Aiyue Luo, Hongyu Li, Xing Lv, Peizhe Zheng, Kehan Lin, Aiting Liang, Shuhong Yang","doi":"10.1080/13697137.2025.2470451","DOIUrl":"https://doi.org/10.1080/13697137.2025.2470451","url":null,"abstract":"Objective: Ovarian aging significantly impacts women's overall aging, affecting various systems including the musculoskeletal system. This study investigates the correlation between ovarian function and handgrip strength (HGS) across reproductive aging stages and their relation to health-related quality of life (HRQoL).Method: A cross-sectional study was conducted with female participants spanning all stages of ovarian function. HGS was measured using a dynamometer, and ovarian function was assessed via hormone levels (estradiol [E2], follicle stimulating hormone [FSH], luteinizing hormone [LH], prolactin [PRL], progesterone [P4] and testosterone). HRQoL was evaluated using the Sarcopenia-specific Quality of Life questionnaire (SarQoL). Data analysis involved analysis of variance and Pearson's correlations, adjusted for confounding factors.Results: The prevalence of possible sarcopenia increased from 3.8% in premenopausal women to 10.3% in postmenopausal women. After adjusting for covariates (age, SarQoL, FSH, LH, FSH/LH ratio, PRL, E2, P4 and testosterone), the negative correlation between HGS and the Kupperman Menopausal Index (KMI) was no longer significant. However, the positive correlation between HGS and the SarQoL remained significant in both the overall population and the postmenopausal group. The negative correlation between HGS and FSH was no longer significant after controlling for age, KMI, LH and E2; however, it persisted after controlling for the SarQoL, FSH/LH ratio, PRL, P4 and testosterone.Conclusion: HGS is positively correlated with the SarQoL and negatively correlated with age in the overall population. No significant association was found between HGS and testosterone, E2, LH or FSH/LH ratio. Further research is needed to clarify the relationship between HGS and the KMI or FSH.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-7"},"PeriodicalIF":2.9,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143662450","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of aerobic and resistance training on bone, muscle hypertrophy and inflammation in OVX mice. 有氧和阻力训练对OVX小鼠骨骼、肌肉肥大和炎症的影响。

IF 2.9 4区医学

Climacteric Pub Date : 2025-03-18 DOI: 10.1080/13697137.2025.2471059

Luciana Botelho Ribeiro, Pedro Gustavo Machado, Juliana Cristina Reis-Canaan, Ivam Moreira de Oliveira Júnior, Natália Oliveira Bertolini, Soraia Macari, Cândido Celso Coimbra, Luciano José Pereira

{"title":"Effects of aerobic and resistance training on bone, muscle hypertrophy and inflammation in OVX mice.","authors":"Luciana Botelho Ribeiro, Pedro Gustavo Machado, Juliana Cristina Reis-Canaan, Ivam Moreira de Oliveira Júnior, Natália Oliveira Bertolini, Soraia Macari, Cândido Celso Coimbra, Luciano José Pereira","doi":"10.1080/13697137.2025.2471059","DOIUrl":"https://doi.org/10.1080/13697137.2025.2471059","url":null,"abstract":"Objective: Bone loss is common with aging, particularly due to reduced sex hormones, as seen in menopause. While physical training is a known non-pharmacological therapy for osteopenia and sarcopenia, few studies compare resistance and aerobic protocols, especially with systemic inflammatory markers. This study evaluated the effects of aerobic and resistance training on physical performance, femoral trabecular bone quality (micro-computed tomography), serum inflammatory markers (IL-1β, IL-6, TNF-α, IL-10) and gastrocnemius muscle area in ovariectomized (OVX) female mice.Method: Sixty-four c57bl/6 mice were divided into OVX and SHAM groups and subjected to sedentary, resistance (climbing) or aerobic (treadmill) protocols for 8 weeks.Results: Training reduced body mass (p < 0.001) in trained animals compared to sedentary. Bone quality was higher in trained groups versus sedentary. OVX increased TNF-α, but training did not alter it. IL-1β levels were higher in climbing than treadmill groups, and IL-6 increased with OVX and aerobic training (p < 0.001). IL-10 was elevated in the SHAM and climbing groups (p < 0.01). Gastrocnemius muscle area increased in both trained groups (p < 0.001) with no differences between modalities.Conclusion: Aerobic and resistance training improved bone quality and muscle area in OVX mice, with climbing training uniquely linked to increased IL-10 levels.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143656459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between blood sex hormones, cognitive decline and incident dementia in community-dwelling older Australian women: a prospective cohort study. 澳大利亚社区老年妇女血液性激素、认知能力下降和痴呆发生率之间的关系：一项前瞻性队列研究

IF 2.9 4区医学

Climacteric Pub Date : 2025-03-14 DOI: 10.1080/13697137.2025.2470458

Farhana Sultana, Susan R Davis, Rory S Wolfe, John J McNeil, Rakibul M Islam

{"title":"Associations between blood sex hormones, cognitive decline and incident dementia in community-dwelling older Australian women: a prospective cohort study.","authors":"Farhana Sultana, Susan R Davis, Rory S Wolfe, John J McNeil, Rakibul M Islam","doi":"10.1080/13697137.2025.2470458","DOIUrl":"https://doi.org/10.1080/13697137.2025.2470458","url":null,"abstract":"Objective: Whether blood sex hormone concentrations predict cognitive decline and incident dementia in older women is uncertain. The Sex Hormones in Older Women (SHOW) study is a prospective cohort study of Australian women, aged at least 70 years, without cognitive impairment.Methods: Sex hormones were measured by liquid chromatography-tandem mass spectrometry, and comprehensive cognitive testing was performed at baseline and 3 years later.Results: Of the 6358 participants who had sex hormones measured, 4444 women (median age at baseline 74 years [Q1-Q3 71.7-77.5]) provided data for cognitive analyses. The findings were limited to a decline in executive function and verbal fluency was positively associated with the highest quartiles of estrone (odds ratio [OR] = 1.21, 95% confidence interval [CI] 1.01-1.45, p = 0.04) and dehydro-epiandrosterone (DHEA) (OR = 1.21, 95% CI 1.01-1.45, p = 0.04), compared with the lowest quartiles. Estrone and DHEA were not associated with any other cognitive decline. Testosterone was not associated with cognitive decline. In an exploratory analysis, cognitive decline was not different in women who had estradiol below the limit of detection (66% of women) compared with women with measurable estradiol. Over a median 4.1 years of follow-up (22,518 person-years), 121 (2.2%) developed dementia; an incident rate of 5.3 per 1000 person-years. There were no associations between any hormone and incident dementia.Conclusions: The finding of a greater likelihood of a decline in executive function and verbal fluency in community-dwelling older women with the highest blood concentrations of DHEA and its metabolite estrone need reaffirmation and their clinical significance should be further investigated. These findings do not support use of estrogen or DHEA therapy to prevent cognitive decline in older women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-10"},"PeriodicalIF":2.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

NK3 receptor antagonist alters the centrally controlled perception of menopausal flushing - a pilot study. NK3受体拮抗剂改变绝经期潮红的中枢控制感知-一项初步研究。

IF 2.9 4区医学

Climacteric Pub Date : 2025-03-14 DOI: 10.1080/13697137.2025.2470462

Jenifer Sassarini, Karolina Skorupskaite, John McLean, Mary Ann Lumsden, Richard A Anderson

{"title":"NK3 receptor antagonist alters the centrally controlled perception of menopausal flushing - a pilot study.","authors":"Jenifer Sassarini, Karolina Skorupskaite, John McLean, Mary Ann Lumsden, Richard A Anderson","doi":"10.1080/13697137.2025.2470462","DOIUrl":"https://doi.org/10.1080/13697137.2025.2470462","url":null,"abstract":"Objective: Kisspeptin/neurokinin/dynorphin (KNDy) signaling links reproductive and thermoregulatory systems, and improvements in menopausal flushing are reported with neurokinin 3 receptor (NK3R) antagonists. A rise in brainstem activity preceding a flush has been proposed as its functional origin, with subsequent activity in the insula and prefrontal cortices reflecting individual perception. Using functional magnetic resonance imaging (fMRI), this study investigated the central effect of the NK3R antagonist MLE4901 during a flush, particularly functional connectivity changes in the salience network.Method: Five postmenopausal women with flushes completed a 1-week flush diary prior to baseline fMRI, during which hot flushes were triggered by heating. Diaries were continued during 7 days of treatment with the NK3R antagonist MLE4901, with repeat fMRI on day 7. Sternal monitors recorded objective flushing before each fMRI. Connectivity changes in the salience network post flush were assessed.Results: Treatment with MLE4901 reduced the subjective flush frequency (from median 6.9 to 1.1 per day; p = 0.02) without changes in objective flushes. Treatment decreased right anterior insula connectivity, which correlated significantly with decreased subjective flushing.Conclusion: This pilot study demonstrates decreased connectivity in the salience network during NK3R antagonist treatment. This may indicate areas of interest for further targeted fMRI studies and mechanistic investigation of this novel treatment for flushing.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143630234","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0