Climacteric最新文献_第6页

Rapid and random-start endometrial preparation before outpatient hysteroscopic polypectomy in patients of perimenopausal age. 围绝经期患者在门诊宫腔镜息肉切除术前快速和随机启动子宫内膜准备。

IF 2.9 4区医学

Climacteric Pub Date : 2024-12-01 Epub Date: 2024-09-27 DOI: 10.1080/13697137.2024.2404574

Andrea Etrusco, Antonio D'Amato, Vittorio Agrifoglio, Vito Chiantera, Giuseppe Russo, Tullio Golia D'Augè, Marco Monti, Gaetano Riemma, Antonio Simone Laganà, Andrea Giannini

{"title":"Rapid and random-start endometrial preparation before outpatient hysteroscopic polypectomy in patients of perimenopausal age.","authors":"Andrea Etrusco, Antonio D'Amato, Vittorio Agrifoglio, Vito Chiantera, Giuseppe Russo, Tullio Golia D'Augè, Marco Monti, Gaetano Riemma, Antonio Simone Laganà, Andrea Giannini","doi":"10.1080/13697137.2024.2404574","DOIUrl":"10.1080/13697137.2024.2404574","url":null,"abstract":"Objective: This study aimed to assess the efficacy of randomly started oral dienogest/ethinylestradiol (DNG/EE) for swift endometrial preparation prior to outpatient hysteroscopic polypectomy in perimenopausal women.Method: A multicenter, prospective, randomized controlled trial was conducted in university hospitals. Eighty perimenopausal women scheduled for outpatient hysteroscopic polypectomy between January 2023 and March 2024 were randomly assigned to either intervention (n = 40) or control (n = 40) groups. Exclusion criteria included concomitant endometrial pathologies, recent therapy and adnexal diseases. The intervention group received oral DNG/EE 2 mg/0.03 mg/day started on any day of the menstrual cycle for 14 days. The control group underwent polypectomy between menstrual cycle days 8 and 11 without pharmacological treatment.Results: Pre-procedure (p < 0.001) and post-procedure (p < 0.001) endometrial thickness were significantly reduced in the intervention group, along with a higher incidence of hypotrophic/atrophic endometrial patterns (p < 0.001). Surgical parameters also differed significantly between groups.Conclusion: DNG/EE treatment offers rapid, cost-effective endometrial preparation, enhancing surgical outcomes and patient satisfaction during outpatient polypectomy.Trial registration: ClinicalTrials.gov NCT06316206.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"561-567"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142342725","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effect of hormone therapy on personality traits: preliminary evidence in older men and women. 荷尔蒙疗法对人格特质的影响：老年男性和女性的初步证据。

IF 2.9 4区医学

Climacteric Pub Date : 2024-12-01 Epub Date: 2024-09-16 DOI: 10.1080/13697137.2024.2393128

Rachel A Schroeder, Kristen L Mordecai, Susan M Resnick, Antonio Terracciano, Adrian Dobs, Samuel C Durso, Paul T Costa, Pauline M Maki

{"title":"Effect of hormone therapy on personality traits: preliminary evidence in older men and women.","authors":"Rachel A Schroeder, Kristen L Mordecai, Susan M Resnick, Antonio Terracciano, Adrian Dobs, Samuel C Durso, Paul T Costa, Pauline M Maki","doi":"10.1080/13697137.2024.2393128","DOIUrl":"10.1080/13697137.2024.2393128","url":null,"abstract":"Objective: Findings concerning the effects of hormone therapy (HT) on cognition and dementia are mixed, with some trials suggesting increased harm at older ages. Personality, like cognition, changes with dementia, but no clinical trials to date have examined the effects of HT on personality traits. This study aimed to determine the effects of HT on personality traits in older men and women.Method: Secondary data analysis was performed from randomized, double-blind, placebo-controlled cross-over studies of menopausal HT in women and testosterone therapy (TT) in men. Participants were community-dwelling cognitively normal adults (mean age = 75.2 years), including 29 men and 22 women. Three months of hormone intervention (for women, 0.625 mg/day conjugated equine estrogen with or without 2.5 mg/day medroxyprogesterone acetate; for men, 200 mg intramuscular testosterone enanthate every 2 weeks) were crossed over with 3 months of identical placebo with a 3-month washout between intervention phases. The main outcome measure was neuroticism and conscientiousness personality domains and facets assessed with the Revised NEO Personality Inventory (NEO-PI-R) after the active and placebo intervention phases.Results: In linear mixed-effect models, HT in women decreased conscientiousness (p < 0.01) and the conscientiousness facet of achievement striving (p < 0.01), and increased vulnerability, a facet of neuroticism (p < 0.05). Testosterone in men decreased conscientiousness (p < 0.05) and the conscientiousness facet of dutifulness (p < 0.05), and increased vulnerability (p < 0.05).Conclusion: In a preliminary study of healthy older adults, HT and TT formulations produced adverse changes in vulnerability and conscientiousness facets that parallel personality changes in dementia.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"526-533"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142281242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Updated premature ovarian insufficiency guideline. 更新卵巢早衰指南。

IF 2.9 4区医学

Climacteric Pub Date : 2024-12-01 Epub Date: 2024-12-16 DOI: 10.1080/13697137.2024.2408922

Nick Panay, Amanda J Vincent

引用次数: 0

Vaginal microbiome of women with premature ovarian insufficiency: a descriptive cross-sectional study. 卵巢早衰妇女的阴道微生物组：一项描述性横断面研究。

IF 2.9 4区医学

Climacteric Pub Date : 2024-12-01 Epub Date: 2024-10-07 DOI: 10.1080/13697137.2024.2393140

Helena Patricia Giraldo, Paulo César Giraldo, Ticiana A Mira, Gabriela Pravatta Rezende, Daniela Angerame Yela, Rose Luce Gomes do Amaral, Cristina Laguna Benetti-Pinto

{"title":"Vaginal microbiome of women with premature ovarian insufficiency: a descriptive cross-sectional study.","authors":"Helena Patricia Giraldo, Paulo César Giraldo, Ticiana A Mira, Gabriela Pravatta Rezende, Daniela Angerame Yela, Rose Luce Gomes do Amaral, Cristina Laguna Benetti-Pinto","doi":"10.1080/13697137.2024.2393140","DOIUrl":"10.1080/13697137.2024.2393140","url":null,"abstract":"Objective: This study aimed to describe the vaginal microbiome of women with premature ovarian insufficiency (POI) receiving systemic hormone therapy (HT).Methods: Forty women with POI receiving systemic HT for at least 6 months, who were sexually active, were included in the descriptive cross-sectional study. Vaginal secretion was collected for DNA extraction followed by pyrosequencing of the 16S rRNA. The samples were pooled into phylogenetic groups (Ravel groups I-V).Results: Women had mean age of 37.13 (± 7.27) years and POI diagnosis at age 27.90 (± 8.68) years, and a mean HT duration of 8.20 (± 8.73) years. It was observed that 33.4% of the women presented group I flora, with a predominance of Lactobacillus crispatus; 9% group II flora, with a predominance of Lactobacillus gasseri; 33.4% group III flora, with a predominance of Lactobacillus iners; 15.2% group IV flora, with a predominance of anaerobic bacteria; and 9% group V flora, with a predominance of Lactobacillus jensenii.Conclusion: Women with POI receiving HT presented a vaginal microbiome with a predominance of lactobacilli in the composition of the vaginal flora, specifically L. crispatus and L. iners when evaluated by molecular biology through pyrosequencing of 16S rRNA.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"542-547"},"PeriodicalIF":2.9,"publicationDate":"2024-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142380160","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Maintaining the menopause momentum. 保持更年期的势头

IF 2.9 4区医学

Climacteric Pub Date : 2024-10-01 Epub Date: 2024-09-25 DOI: 10.1080/13697137.2024.2395137

Tim Hillard

引用次数: 0

Menopausal age does not affect ventricular structure and function: a Mendelian randomization study. 绝经年龄不会影响心室结构和功能：孟德尔随机研究。

IF 2.9 4区医学

Climacteric Pub Date : 2024-10-01 Epub Date: 2024-07-25 DOI: 10.1080/13697137.2024.2380009

Youjie Zeng, Si Cao, Yuan Yuan

{"title":"Menopausal age does not affect ventricular structure and function: a Mendelian randomization study.","authors":"Youjie Zeng, Si Cao, Yuan Yuan","doi":"10.1080/13697137.2024.2380009","DOIUrl":"10.1080/13697137.2024.2380009","url":null,"abstract":"Objectives: Observational studies have suggested an association between age at natural menopause (ANM) and ventricular structure and function. Nevertheless, the causal relationship remains unclear. This study aimed to evaluate the causal effects of ANM on ventricular structure and function by Mendelian randomization (MR) analysis.Methods: Genome-wide association summary statistics for ANM and 16 ventricular structures and functions were obtained. The inverse variance weighted (IVW) method was the primary MR approach for assessing causal associations. In addition, three additional MR methods (MR-Egger, weighted median and weighted mode) were performed to complement the IVW method. Furthermore, various sensitivity tests were conducted to evaluate the reliability of the MR results.Results: The IVW method identified no causal association between ANM and all 16 ventricular structures or functions (p > 0.05). Three additional MR methods yielded parallel results to the IVW approach (p > 0.05). Various sensitivity tests revealed stability of the MR results, indicating no heterogeneity or horizontal pleiotropy.Conclusion: The present MR study indicated that ANM would not causally affect ventricular structure or function. Therefore, the correlation between ANM and ventricular characteristics in previous observational studies might be attributed to shared upstream cardiovascular risk factors or unidentified genetic mutations that simultaneously affect both ANM and ventricular structure and function.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"501-506"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141757464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Ultra-low-dose estradiol and dydrogesterone for treatment of vasomotor symptoms in Europe and China. 欧洲和中国用于治疗血管运动症状的超低剂量雌二醇和地屈孕酮。

IF 2.9 4区医学

Climacteric Pub Date : 2024-10-01 Epub Date: 2024-07-30 DOI: 10.1080/13697137.2024.2380364

Qi Yu, John C Stevenson, Tetiana Tatarchuk, Rossella E Nappi, Marcelo Graziano Custodio, Elke Kahler, Tommaso Simoncini, Junyi Yang, Mulan Ren

{"title":"Ultra-low-dose estradiol and dydrogesterone for treatment of vasomotor symptoms in Europe and China.","authors":"Qi Yu, John C Stevenson, Tetiana Tatarchuk, Rossella E Nappi, Marcelo Graziano Custodio, Elke Kahler, Tommaso Simoncini, Junyi Yang, Mulan Ren","doi":"10.1080/13697137.2024.2380364","DOIUrl":"10.1080/13697137.2024.2380364","url":null,"abstract":"Objective: Among postmenopausal women, oral, ultra-low-dose continuous combined estradiol (E0.5 mg) plus dydrogesterone (D2.5 mg) reduces vasomotor symptoms (VMS).Methods: This study was a post hoc analysis of data from two phase 3, double-blind studies. Postmenopausal women were randomized 2:1:2 to receive E0.5 mg/D2.5 mg, E1 mg/D5 mg (not included in this analysis) or placebo for 13 weeks (European study), or randomized 1:1 to receive E0.5 mg/D2.5 mg or placebo for 12 weeks (Chinese study). Endpoints assessed in ethnicity subgroups (European and Chinese) included changes from baseline in number of hot flushes, number of moderate-to-severe hot flushes and Menopause Rating Scale (MRS) score.Results: Overall, 579 women were included in the analysis (E0.5 mg/D2.5 mg, n = 288; placebo, n = 291). European and Chinese women receiving E0.5 mg/D2.5 mg experienced greater reductions from baseline in mean daily number of hot flushes and mean daily number of moderate-to-severe hot flushes at week 4, week 8 and end of treatment versus those receiving placebo. Significant improvements in the 'hot flushes, sweating' MRS item score were reported in both European and Chinese women.Conclusion: Oral, ultra-low-dose continuous combined 0.5 mg 17β-estradiol and 2.5 mg dydrogesterone improved VMS compared with placebo in European and Chinese postmenopausal women, with a positive impact on health-related quality of life.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"494-500"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141792000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Climacteric and fibromyalgia: a review. Climacteric and fibromyalgia: a review.

IF 2.9 4区医学

Climacteric Pub Date : 2024-10-01 Epub Date: 2024-07-22 DOI: 10.1080/13697137.2024.2376190

Luis Fernando Vidal-Neira, José Luis Neyro, Genessis Maldonado, Osvaldo Daniel Messina, Mario Moreno-Alvarez, Carlos Ríos

引用次数: 0

Risk of endometrial malignancy in women treated for breast cancer: the BLUSH prediction model - evidence from a comprehensive multicentric retrospective cohort study. 接受过乳腺癌治疗的妇女发生子宫内膜恶性肿瘤的风险：BLUSH 预测模型--来自一项综合性多中心回顾性队列研究的证据。

IF 2.9 4区医学

Climacteric Pub Date : 2024-10-01 Epub Date: 2024-07-18 DOI: 10.1080/13697137.2024.2376189

Salvatore Giovanni Vitale, Stefano Angioni, Maurizio Nicola D'Alterio, Carlo Ronsini, Stefania Saponara, Pasquale De Franciscis, Gaetano Riemma

{"title":"Risk of endometrial malignancy in women treated for breast cancer: the BLUSH prediction model - evidence from a comprehensive multicentric retrospective cohort study.","authors":"Salvatore Giovanni Vitale, Stefano Angioni, Maurizio Nicola D'Alterio, Carlo Ronsini, Stefania Saponara, Pasquale De Franciscis, Gaetano Riemma","doi":"10.1080/13697137.2024.2376189","DOIUrl":"10.1080/13697137.2024.2376189","url":null,"abstract":"Objective: This study aimed to evaluate characteristics of endometrial surveillance in women treated for breast cancer to build a clinical prediction model.Design: A multicentric retrospective cohort study was conducted at two tertiary-care university hospitals from January 2020 to June 2023. Perimenopausal and postmenopausal women treated for breast cancer were categorized into two groups: patients with and without diagnosis of endometrial malignancy (endometrial carcinoma) or premalignancy (atypical endometrial hyperplasia). Characteristics of breast cancer and ultrasonographic and hysteroscopic examinations were compared. A prediction model for endometrial malignancy was built using logistic regression. Predictive accuracy was assessed using the receiver operating characteristic (ROC) curve and goodness of fit using the Hosmer-Lemeshow test.Results: One hundred and thirty-two (28 with premalignancy or malignancy and 104 without malignancy) women were analyzed. A nomogram was produced for prediction model development utilizing the presence and duration in months of abnormal uterine (BL)eeding, ultrasound (US) vascular pattern and echogenicity and (H)ysteroscopic appearance of endometrium (BLUSH) as determined by logistic regression. Sensitivity and specificity were 79.17% and 95.19%, respectively, with an area under ROC curve of 0.965, indicating good accuracy. Good goodness of fit and prediction stability were indicated by the calibration curve and Hosmer-Lemeshow test (χ2 = 26.36; p = 0.999).Conclusions: Breast cancer survivors undergoing endometrial surveillance might benefit from a potentially useful prediction model based on hysteroscopic appearance, ultrasonographic uniformity of endometrium, Doppler flow and presence of abnormal uterine bleeding.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"482-488"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141632822","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Use of an estradiol transdermal spray in women with menopausal symptoms: a non-interventional study. 在有更年期症状的妇女中使用雌二醇透皮喷雾剂：一项非干预性研究。

IF 2.9 4区医学

Climacteric Pub Date : 2024-10-01 Epub Date: 2024-07-22 DOI: 10.1080/13697137.2024.2376185

Peyman Hadji, Jens-Olaf Schmeißer, Klaus Peters, Erwin Göckeler-Leopold

{"title":"Use of an estradiol transdermal spray in women with menopausal symptoms: a non-interventional study.","authors":"Peyman Hadji, Jens-Olaf Schmeißer, Klaus Peters, Erwin Göckeler-Leopold","doi":"10.1080/13697137.2024.2376185","DOIUrl":"10.1080/13697137.2024.2376185","url":null,"abstract":"Objective: This study aimed to investigate the effectiveness, tolerability and application of estradiol metered-dose transdermal spray (EMDTS) in postmenopausal women during real-world use.Methods: This was a prospective, non-interventional, multicenter, observational phase IV cohort study. The Menopause Rating Scale II (MRS II) was used to assess symptoms and clinical response. Safety was assessed by the occurrence of adverse events and adverse drug reactions (ADRs).Results: A total of 451 postmenopausal women were enrolled at 52 gynecological practices across Germany; 383 patients were evaluated for effectiveness and 430 patients for safety. Mean age was 54.3 ± 7.4 years. In total, 228 patients (59.5%) received EMDTS monotherapy and 155 patients (40.5%) received EMDTS plus progestogens. Significant improvements (p < 0.0001) from baseline in symptom severity were recorded for all 11 items of the MRS II at 3, 6 and 12 months of treatment. At 12 months, 81.4% of patients reported improvement in hot flushes/sweating. At final visit, 73% of patients and 77% of physicians were 'satisfied/very pleased' with EMDTS. Most common ADRs were headache (n = 6), nausea (n = 4), dizziness (n = 4) and pruritus (n = 3).Conclusions: EMDTS is an effective, well tolerated and easily applied hormone replacement therapy for women experiencing postmenopausal symptoms.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"473-481"},"PeriodicalIF":2.9,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141733679","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0