Climacteric最新文献_第6页

State of the art in menopause: current best practice approaches from the IMS World Congress 2024, Melbourne. 绝经的最新技术：来自墨尔本2024年IMS世界大会的当前最佳实践方法。

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2025-02-10 DOI: 10.1080/13697137.2025.2457993

James A Simon, Susan R Davis, Angelica Lindén Hirschberg, Ludwig Kiesel, Luciano de Melo Pompei, Jean-Yves Reginster, Tommaso Simoncini, Timothy Hillard

{"title":"State of the art in menopause: current best practice approaches from the IMS World Congress 2024, Melbourne.","authors":"James A Simon, Susan R Davis, Angelica Lindén Hirschberg, Ludwig Kiesel, Luciano de Melo Pompei, Jean-Yves Reginster, Tommaso Simoncini, Timothy Hillard","doi":"10.1080/13697137.2025.2457993","DOIUrl":"10.1080/13697137.2025.2457993","url":null,"abstract":"The 19th World Congress on Menopause, hosted by the International Menopause Society in 2024, convened global experts to discuss the latest advances in menopause management. This review highlights key focus areas presented at the congress, offering insights into best practices for clinical application. Cardiovascular health remains a priority, with emphasis on recognizing sex-specific risk factors and exploring emerging therapies. Osteoporosis management underscores the role of menopausal hormone therapy (MHT) as foundational, complemented by anti-resorptive and bone-forming agents in high-risk populations and those not candidates for MHT. Addressing genitourinary symptoms and sexual health, vaginal estrogen therapy is confirmed as a safe and effective option with vaginal dehydroepiandrosterone (DHEA) and oral ospemifene as suitable alternatives, while testosterone therapy offers benefits for hypoactive sexual desire disorder in postmenopausal women. Sleep disturbances, depression and workplace challenges linked to menopause were explored, with tailored interventions such as MHT and cognitive behavioral therapy specifically for sleep recommended. Cancer risk management stressed the need for a multidisciplinary approach to risk reduction beginning with lifestyle modification, and with non-hormonal therapies prioritized for symptomatic treatment of menopausal symptoms in those with hormone-sensitive cancers. Lastly, perimenopause management highlighted comprehensive approaches integrating symptom relief and contraceptive needs.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"98-103"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143381717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of serum uric acid with handgrip strength and dynapenia in postmenopausal women. 血清尿酸与绝经后妇女握力和运动障碍的关系。

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2024-12-02 DOI: 10.1080/13697137.2024.2429423

Pascual García-Alfaro, Faustino R Pérez-López, Ignacio Rodríguez

{"title":"Association of serum uric acid with handgrip strength and dynapenia in postmenopausal women.","authors":"Pascual García-Alfaro, Faustino R Pérez-López, Ignacio Rodríguez","doi":"10.1080/13697137.2024.2429423","DOIUrl":"10.1080/13697137.2024.2429423","url":null,"abstract":"Objective: This study aimed to examine the association of serum uric acid levels with handgrip strength (HGS) and dynapenia in postmenopausal women.Methods: A cross-sectional study among 422 participants collected data on age, age at menopause, adiposity, alcohol consumption, body mass index, current smoking status, HGS (measured using a digital dynamometer) and physical activity. Serum levels of creatinine, glucose, glycated hemoglobin, total cholesterol, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, thyroid-stimulating hormone and uric acid were evaluated. Women were categorized into quartiles. A directed acyclic graph was designed to identify confounding variables. Multivariable regression analysis was used to assess associations between uric acid with HGS or dynapenia.Results: Women with hyperuricemia presented significant association with lower HGS (p = 0.00028). After adjusting for potential confounders, the multivariable linear regression to analyze the association between uric acid and HGS showed an inverted U-shaped curve, with quartile 1 (β = -0.54; 95% confidence interval [CI]: -1.50, 0.40), quartile 3 (β = -0.21; 95% CI: -1.20, 0.74) and quartile 4 (β = -1.3; 95% CI: -2.3, -0.37) compared with quartile 2. Serum uric acid levels were significantly associated with HGS (p = 0.036).Conclusions: The association between uric acid quartiles with HGS or dynapenia displayed an inverted U-shaped curve. These findings suggest that specific serum uric acid levels within the normal range are associated with better HGS.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"126-132"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142766774","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparing for the future: artificial intelligence in menopausal health care. 为未来做准备：人工智能在更年期保健中的应用。

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2025-03-07 DOI: 10.1080/13697137.2025.2469476

Seng Bin Ang, Tim Hillard

引用次数: 0

Knowledge and attitudes of premenopausal women in southern China toward menopause and menopausal hormone therapy. 华南地区绝经前妇女对绝经及绝经期激素治疗的认识和态度。

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2025-02-07 DOI: 10.1080/13697137.2025.2455168

Yan Zhang, Xiujuan Chen, Yuan Lin, Xiaoqing Liu, Xiumei Xiong

{"title":"Knowledge and attitudes of premenopausal women in southern China toward menopause and menopausal hormone therapy.","authors":"Yan Zhang, Xiujuan Chen, Yuan Lin, Xiaoqing Liu, Xiumei Xiong","doi":"10.1080/13697137.2025.2455168","DOIUrl":"10.1080/13697137.2025.2455168","url":null,"abstract":"Objective: Menopause is a significant and natural phase in a woman's life, representing a transition that requires early understanding to manage its effects and promote overall well-being. This study aimed to evaluate the awareness, understanding and perceptions of menopause and menopausal hormone therapy (MHT) among premenopausal women in southern China.Methods: A cross-sectional design was employed to enroll women aged 18-40 years (n = 1631) from August 2022 to January 2023 at a public hospital in Fujian, China. A structured questionnaire, developed from existing research and the Climacteric Scale, was used to assess women's menopausal symptoms and MHT knowledge. Face-to-face interviews were conducted to identify factors correlated with menopausal knowledge levels.Results: More than 50% of women demonstrated a comprehensive understanding of menopause. Education level was a significant predictor of menopause knowledge (p < 0.001), with women holding higher education (college degree or above) demonstrating greater knowledge than those with lower education (high school or below). High awareness of common menopausal symptoms, including irritability, sleep disturbances, fatigue, difficulty concentrating and hot flashes, was observed. Although most participants lacked detailed knowledge of MHT, they agreed on the importance of managing menopausal symptoms and recognized the usefulness of MHT for symptom management.Conclusions: Premenopausal women in southern China possess a basic understanding of menopause but lack sufficient knowledge about MHT. This highlights the need for educational initiatives and targeted counseling to increase awareness of menopause and MHT, especially regarding its implications and treatment options.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"191-199"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143363794","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Skin temperature and nitric oxide in premenopausal and postmenopausal women with fibromyalgia. 绝经前和绝经后纤维肌痛妇女的皮肤温度和一氧化氮。

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2025-02-26 DOI: 10.1080/13697137.2025.2465294

Alma Rus, Bárbara Coca-Guzmán, Antonio Casas-Barragán, Francisco Molina, María Correa-Rodríguez, María Encarnación Aguilar-Ferrándiz

{"title":"Skin temperature and nitric oxide in premenopausal and postmenopausal women with fibromyalgia.","authors":"Alma Rus, Bárbara Coca-Guzmán, Antonio Casas-Barragán, Francisco Molina, María Correa-Rodríguez, María Encarnación Aguilar-Ferrándiz","doi":"10.1080/13697137.2025.2465294","DOIUrl":"10.1080/13697137.2025.2465294","url":null,"abstract":"Objective: This study aimed to investigate skin temperature, indicative of peripheral vascular blood flow, core body temperature and nitric oxide (NO) levels in premenopausal and postmenopausal women with fibromyalgia (FM) and controls.Method: A case-control study was carried out in 32 healthy premenopausal and 52 healthy postmenopausal women and in 17 premenopausal and 53 postmenopausal women with FM. Hand skin temperature was measured using infrared thermography, tympanic and axillary temperature with an infrared thermometer, and serum NO levels using an ozone chemiluminescence-based method.Results: Tympanic temperature was higher in postmenopausal women with FM than in postmenopausal controls. Significant differences were found in all of the temperatures recorded in both hands between healthy premenopausal women and premenopausal women with FM and between postmenopausal controls and postmenopausal women with FM. No differences were found in hand temperature, axillary or tympanic temperature, or NO levels between healthy premenopausal and postmenopausal women or between premenopausal and postmenopausal women with FM.Conclusion: The association between menopause and FM could be responsible for the higher tympanic temperature observed in women with FM. FM, but not menopause, may increase hand skin temperature, which could be indicative of excessive peripheral vasodilation. Menopause may not alter body temperature or NO levels in either patients with FM or healthy women.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"133-142"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143499028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Vaginal oxygen plus hyaluronic acid on lower urinary tract symptoms in breast cancer survivors. 阴道氧加透明质酸对乳腺癌幸存者下尿路症状的影响

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2025-02-04 DOI: 10.1080/13697137.2025.2455182

Giorgia Asinaro, Claudia Massarotti, Valentina Musante, Marta Fiamberti, Beatrice Marchese, Matteo Lambertini, Lucia Del Mastro, Ambrogio P Londero, Angelo Cagnacci

{"title":"Vaginal oxygen plus hyaluronic acid on lower urinary tract symptoms in breast cancer survivors.","authors":"Giorgia Asinaro, Claudia Massarotti, Valentina Musante, Marta Fiamberti, Beatrice Marchese, Matteo Lambertini, Lucia Del Mastro, Ambrogio P Londero, Angelo Cagnacci","doi":"10.1080/13697137.2025.2455182","DOIUrl":"10.1080/13697137.2025.2455182","url":null,"abstract":"Objective: This study aimed to evaluate the effect of vaginal oxygen and hyaluronic acid on lower urinary tract symptoms (LUTS) in breast cancer survivors.Method: A prospective trial was conducted at a university hospital's Menopause Outpatient Clinic. Breast cancer patients experiencing LUTS received intravaginal natural oxygen for 15 min, coupled with a 2% hyaluronic acid solution during the last 5 min. This treatment was performed five times at 15-day intervals. Assessments were repeated at each application and 60 days after the last application. Scores on the Urogenital Distress Inventory-6 (UDI-6) short form and its single items assessing different LUTS aspects were determined.Results: Treatment in 85 breast cancer patients decreased the UDI-6 total score (from 24.8 ± 19.9 to 17.5 ± 16.2; p < 0.001) and subscales evaluating irritative (p = 0.001), stress (p = 0.006) and obstructive discomfort (p = 0.001) symptoms. In multivariate analysis, aromatase inhibitors were independently associated with a greater improvement of LUTS (coefficient of regression [CR] - 8.05, 95% confidence interval [CI] -13.41, -2.64; p = 0.004)). The use of a gonadotrophin-releasing hormone (GnRH) analog was associated with a greater improvement of irritative symptoms (CR -2.42, 95% CI -4.75, -0.08; p = 0.042), while tamoxifen reduced the improvement of stress symptoms (CR 2.49, 95% CI 0.10, 4.90; p = 0.041).Conclusion: Short-term treatment with vaginal oxygen and hyaluronic acid appeared to improve LUTS of breast cancer patients.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"169-174"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143188153","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Second pregnancy in China 5 years after ovarian tissue transplantation to prevent iatrogenic POI. 中国卵巢组织移植5年后再次妊娠，以防止先天性子宫内膜异位症。

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2025-03-10 DOI: 10.1080/13697137.2025.2471062

Xiangyan Ruan, Juan Du, Fengyu Jin, Muqing Gu, Jiaojiao Cheng, Yanglu Li, Yinmei Dai, Matthias Korell, Markus Montag, Jana Liebenthron, Alfred O Mueck

{"title":"Second pregnancy in China 5 years after ovarian tissue transplantation to prevent iatrogenic POI.","authors":"Xiangyan Ruan, Juan Du, Fengyu Jin, Muqing Gu, Jiaojiao Cheng, Yanglu Li, Yinmei Dai, Matthias Korell, Markus Montag, Jana Liebenthron, Alfred O Mueck","doi":"10.1080/13697137.2025.2471062","DOIUrl":"10.1080/13697137.2025.2471062","url":null,"abstract":"Objective: This article reports the second live birth in China after frozen-thawed ovarian tissue transplantation to prevent iatrogenic premature ovarian insufficiency (POI).Method: A patient with aplastic anemia received ovarian tissue cryopreservation before hematopoietic stem cell transplantation, and four ovarian cortex strips were thawed and transplanted into her peritoneal pocket 18 months later.Results: Pregnancy occurred spontaneously 5 years after grafting, and a healthy girl was born at 39 weeks of gestation. Until now, the child has developed normally without any major diseases.Conclusion: Ovarian tissue cryopreservation and transplantation (OTCT) can be assessed as a successful method especially to prevent iatrogenic POI. In our cryobank for OTCT, which is the first official one in China, intensive research to improve this method has been performed, and we propose after our success for the second pregnancy in China to include this method in the official guidelines for prevention and treatment of (especially iatrogenic) POI.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"212-216"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143596422","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Estrogen as a guardian of auditory health: Tsp1-CD47 axis regulation and noise-induced hearing loss. 雌激素是听觉健康的守护者：Tsp1-CD47轴调节与噪音诱发的听力损失

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2023-12-18 DOI: 10.1080/13697137.2023.2287632

X Wang, H Zheng, B Yang, M Zu, Z Wang, J Zhang, F Zheng, M Yang, M C F Tong, L Zhao, W Bai

{"title":"Estrogen as a guardian of auditory health: Tsp1-CD47 axis regulation and noise-induced hearing loss.","authors":"X Wang, H Zheng, B Yang, M Zu, Z Wang, J Zhang, F Zheng, M Yang, M C F Tong, L Zhao, W Bai","doi":"10.1080/13697137.2023.2287632","DOIUrl":"10.1080/13697137.2023.2287632","url":null,"abstract":"Objectives: This study aimed to analyze the role of estrogen in noise-induced hearing loss (NIHL) and uncover underlying mechanisms.Methods: An ovariectomized Sprague-Dawley rat model (OVX) was constructed to investigate the hearing threshold and auditory latency before and after noise exposure using the auditory brainstem response (ABR) test. The morphological changes were assessed using immunofluorescence, scanning electron microscopy and transmission electron microscopy. Proteomics and bioinformatics were used to analyze the mechanism. The findings were further verified through western blot and Luminex liquid suspension chip technology.Results: After noise exposure, OVX rats exhibited substantially elevated hearing thresholds. A conspicuous delay in ABR wave I latency was observed, alongside increased loss of outer hair cells, severe collapse of stereocilia and pronounced deformation of the epidermal plate. Accordingly, OVX rats with estrogen supplementation exhibited tolerance to NIHL. Additionally, a remarkable upregulation of the thrombospondin 1 (Tsp1)-CD47 axis in OVX rats was discovered and verified.Conclusions: OVX rats were more susceptible to NIHL, and the protective effect of estrogen was achieved through regulation of the Tsp1-CD47 axis. This study presents a novel mechanism through which estrogen regulates NIHL and offers a potential intervention strategy for the clinical treatment of NIHL.","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"143-153"},"PeriodicalIF":2.9,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138799369","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Peer reviewers for Climacteric in 2024. 2024年《更年期》杂志的同行评审。

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2025-02-26 DOI: 10.1080/13697137.2025.2459539

引用次数: 0

Unraveling sleep quality in menopausal women: objective assessments and self-reported experiences - a mini-review. 揭示更年期妇女的睡眠质量：客观评估和自我报告的经验-一个小型回顾。

IF 2.9 4区医学

Climacteric Pub Date : 2025-04-01 Epub Date: 2025-03-11 DOI: 10.1080/13697137.2025.2470450

Lixia Wang, Yi Xiao, Min Luo, Rong Huang

引用次数: 0