Climacteric最新文献

{"title":"Heart matters: the unique landscape of cardiovascular health in women.","authors":"Gemma A Figtree, Michael P Gray","doi":"10.1080/13697137.2025.2497419","DOIUrl":"10.1080/13697137.2025.2497419","url":null,"abstract":"<p><p>Cardiovascular disease (CVD) remains the leading cause of death globally, despite significant public health efforts. The identification and targeting of modifiable risk factors - including hypertension, dyslipidemia, diabetes mellitus, smoking and obesity - have led to significant improvements in patient outcomes over the past 60 years. However, current strategies based on this model have been shown to underestimate CVD risk in women and they are less frequently targeted compared to men. In addition, female-specific biological differences known to contribute to CVD are frequently understudied or excluded from risk stratification efforts. This review explores the unique epidemiological burden, pathobiology and outcomes of CVD in women; the influence of traditional and sex-specific risk factors; and both diagnostic and therapeutic strategies that may improve clinical outcomes in the future.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-6"},"PeriodicalIF":2.9,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076327","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Profile and risk stratification for sarcopenia in postmenopausal women.","authors":"Marcelo Luis Steiner, Larissa Gabrielli Lima de Campos, Marina Martinelli Sonnenfeld, Tayná Gueler Silva, Mariliza Henrique da Silva, Rodolfo Strufaldi, Cesar Eduardo Fernandes, Luciano de Melo Pompei","doi":"10.1080/13697137.2025.2495310","DOIUrl":"https://doi.org/10.1080/13697137.2025.2495310","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to assess the risk factors associated with sarcopenia and identify risk profiles through cluster analysis in postmenopausal women treated at specialized outpatient clinics.</p><p><strong>Methods: </strong>A retrospective cross-sectional study evaluated data from 287 postmenopausal women. Sarcopenia was determined by handgrip and gait speed testing. Cluster analysis was applied to identify risk subgroups, and logistic regression to identify factors associated with sarcopenia.</p><p><strong>Results: </strong>Sarcopenia was identified in 18.50% of women. Advanced age (odds ratio [OR] = 1.12; 95% confidence interval [CI]: 1.07-1.16; <i>p</i> < 0.01), number of pregnancies (OR = 1.14; 95% CI: 1.00-1.29; <i>p</i> = 0.04), hip Fracture Risk Assessment Tool (FRAX) (OR = 1.29; 95% CI: 1.12-1.49; <i>p</i> < 0.01), systemic arterial hypertension (OR = 3.20; 95% CI: 1.66-6.17; <i>p</i> < 0.01) and multiple comorbidities (OR = 2.46; 95% CI: 1.19-5.09, <i>p</i> = 0.01) were associated with higher risk for sarcopenia. Cluster analysis revealed an increased risk profile for women who were aged over 70 years, multiparous, hypertensive, with hip FRAX greater than 3% and with major fractures greater than 6%.</p><p><strong>Conclusion: </strong>Postmenopausal women with sarcopenia are more likely to have fragility fractures at 10 years, to be older, multiparous and hypertensive, and to have multiple comorbidities.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-7"},"PeriodicalIF":2.9,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144076342","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of menopause hormone therapy and serotonin reuptake inhibitors.","authors":"Natalia Pereira de Oliveira, Luciano de Melo Pompei","doi":"10.1080/13697137.2025.2486051","DOIUrl":"https://doi.org/10.1080/13697137.2025.2486051","url":null,"abstract":"<p><strong>Objective: </strong>Postmenopausal hypoestrogenism may cause significant changes in the oral cavity, interfering with inflammatory mechanisms such as salivary secretion. This study aimed to compare the salivary flow, pH levels and prevalence of dry mouth in postmenopausal women treated with hormone replacement therapy (HRT), those treated with selective serotonin reuptake inhibitors (SSRIs) and those without treatment.</p><p><strong>Methods: </strong>Ninety postmenopausal women participated in the study. Of these, 30 used HRT, 30 used SSRIs and 30 did not receive any treatment (control). Salivary flow was measured using stimulated sialometry, while the pH level was measured using pH strips. Meanwhile, a questionnaire was used to assess for xerostomia.</p><p><strong>Results: </strong>The salivary flow measurements were 1.66 ± 0.49 ml/min for the HRT group, 1.23 ± 0.50 ml/min for the SSRI group and 1.68 ± 0.65 ml/min for the control group (<i>p</i> = 0.005 for comparison). The pH values were 7.13 ± 0.43, 7.0 ± 0.26 and 6.97 ± 0.41 for the HRT, SSRI and control groups, respectively. Xerostomia was reported in 60% of women receiving HRT, 46.7% receiving SSRIs and 26.7% of the controls (<i>p</i> = 0.033).</p><p><strong>Conclusion: </strong>Women using SSRIs had lower salivary flow than the HRT or control group. However, xerostomia was more prevalent in women receiving HRT.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-5"},"PeriodicalIF":2.9,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143980768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severe obesity and menopause symptoms are associated with cognitive impairment in postmenopausal women from Latin America.","authors":"Juan Enrique Blümel, Maria Soledad Vallejo, Peter Chedraui, Socrates Aedo, Marcio Alexandre Hipolito Rodrigues, Carlos Salinas, Konstantinos Tserotas, Andres Calle, Maribel Dextre, Alejandra Elizalde, Carlos Escalante Gomez, Gustavo Gómez-Tabares, Álvaro de Jesus Monterrosa-Castro, Maria T Espinoza, Monica Ñañez, Eliana Ojeda, Claudia Rey, Doris Rodríguez-Vidal","doi":"10.1080/13697137.2025.2491637","DOIUrl":"https://doi.org/10.1080/13697137.2025.2491637","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to evaluate the association between obesity and cognitive impairment.</p><p><strong>Methods: </strong>This study is a sub-analysis of an observational, cross-sectional study in nine Latin American counties. Sociodemographic, clinical and anthropometric data were collected, and cognition was assessed using the Montreal Cognitive Assessment (MoCA) tool in 722 postmenopausal women.</p><p><strong>Results: </strong>The mean age, body mass index (BMI) and years of education of the cohort were 56.9 years, 26.8 kg/m² and 13.6 years, respectively. Women with cognitive impairment, compared to those without, had a higher BMI (27.8 ± 5.9 vs. 26.6 ± 4.9 kg/m², <i>p =</i> 0.037), had more children (3.1 ± 2.4 vs. 2.5 ± 1.7, <i>p =</i> 0.023), experienced more severe menopausal symptoms (56.3% vs. 31.9%, <i>p</i> < 0.001) and presented more comorbidities (60.0% vs. 43.8%, <i>p =</i> 0.006). They also had fewer years of study (10.8 ± 5.1 vs. 13.9 ± 4.9 years, <i>p =</i> 0.001), were less physically active (35.0% vs. 49.1%, <i>p =</i> 0.018) and were less likely to use menopausal hormone therapy (MHT) (11.3% vs. 28.8%, <i>p =</i> 0.001). In binary logistic regression analysis, BMI ≥ 35.0 kg/m² (odds ratio [OR] 2.27, 95% confidence interval [CI] 1.08-4.76) and severe menopausal symptoms (OR 2.10, 95% CI 1.29-3.43) were associated with cognitive impairment. In the model, factors related to lower risk were ever use of MHT (OR 0.44, 95% CI 0.21-0.92) and having more years of education (OR 0.38, 95% CI 0.20-0.64).</p><p><strong>Conclusion: </strong>Severe obesity and severe menopausal symptoms increased the risk of cognitive impairment in postmenopausal women, while higher education and ever use of MHT were protective factors.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-6"},"PeriodicalIF":2.9,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143993278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bringing sex back into the relationship in midlife couples.","authors":"Rossella E Nappi, Lara Tiranini, Ellis Martini, Silvia Martella, Federica Barbagallo, Laura Cucinella","doi":"10.1080/13697137.2025.2489460","DOIUrl":"https://doi.org/10.1080/13697137.2025.2489460","url":null,"abstract":"<p><p>Sexual health and sexual well-being are important components of the overall quality of life at midlife, a turning point carrying several biopsychosocial changes. As people age, they are likely to observe a significant increase in sexual difficulties in both sexes affecting every domain of sexual response, and a decline in the frequency of engaging in sexual activity. Women may report hypoactive sexual desire disorder (HSDD) and genitourinary syndrome of menopause (GSM), two very common biologically driven midlife conditions that are often comorbid and may also be influenced by a multitude of individual and contextual risk factors. An appropriate and timely diagnosis is important to avoid chronification of sexual dysfunction that may become refractory to treatment. The therapeutic algorithm comprises a multidisciplinary approach, including pharmacologic and non-pharmacologic management. Individualized treatment is the key to providing integrated care with positive attitudes for the aging couples in order to expand the 'sexspan' of both partners. This article reports our point of view on the topic of midlife sexuality in the context of a stable relationship, as presented at the 19th World Congress on Menopause in Melbourne (Australia) on 22 October 2024.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-6"},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143974677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of jazz dance and concurrent training on physical variables in postmenopausal women.","authors":"Danielly Yani Fausto, Julia Beatriz Bocchi Martins, Ana Rafaela Amaral da Rocha, Priscila Rodrigues Gil, Cíntia de la Rocha Freitas, Andreia Pelegrini, Adriana Coutinho de Azevedo Guimarães","doi":"10.1080/13697137.2025.2486052","DOIUrl":"https://doi.org/10.1080/13697137.2025.2486052","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to analyze the effects of jazz dance or concurrent training on the cardiorespiratory fitness (CRF), muscle strength and sleep quality of postmenopausal women.</p><p><strong>Method: </strong>A randomized clinical trial with 6-month and 12-month follow-up was conducted including 70 postmenopausal women (mean age 53.19 ± 3.39 years). Participants were randomized into the jazz dance intervention (JD) group, concurrent training intervention (CT) group and control group (CG). CRF was assessed using the 6-min walk test, muscle strength using the isokinetic dynamometer and sleep quality using the Pittsburgh Sleep Quality Index questionnaire. Generalized estimating equations with post-hoc minimum significant difference were used, and intention-to-treat and protocol adherence analyses were performed.</p><p><strong>Results: </strong>CRF showed changes between groups, times and interactions, but the CT group achieved greater gains compared to the JD group. Isokinetic strength showed long-term intragroup improvement for both intervention groups, at peak extension and flexion. Intergroup differences were observed, with the JD group presenting higher means in peak extension at all times compared to the CG post intervention; however, the CT group achieved higher means compared to the JD group; and at peak flexion, the JD group presented with higher averages compared to the CG post intervention. The JD group showed an improvement in sleep duration in the short term, while the CT group did so at the 6-month follow-up. There were intergroup changes in the reduction in sleep medication in both intervention groups compared to the CG.</p><p><strong>Conclusion: </strong>Both modalities are effective for improving CRF, muscle strength and sleep quality.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-10"},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143966805","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sexual counseling based on the BETTER model in postmenopausal women: a randomized controlled trial.","authors":"Negin Bahri, Hedyeh Riazi, Zohreh Keshavarz, Ali Montazeri","doi":"10.1080/13697137.2025.2486049","DOIUrl":"https://doi.org/10.1080/13697137.2025.2486049","url":null,"abstract":"<p><strong>Objective: </strong>Sexual dysfunction and sexual dysfunctional beliefs are common problems in postmenopausal women. The purpose of this study was to evaluate the effect of sexual counseling based on the BETTER (Bring up, Explain, Tell, Time, Educate, Record) model in these women.</p><p><strong>Methods: </strong>The randomized controlled trial study was conducted with 106 postmenopausal women in 2023. Eligible women were assigned randomly to the intervention and control groups. Accordingly, the intervention group received two individual counseling sessions based on the BETTER model. The Female Sexual Function Index (FSFI) and the Sexual Dysfunctional Beliefs Questionnaire (SDBQ) were used for collecting data at baseline and 4 weeks after the intervention.</p><p><strong>Results: </strong>The sexual function score in the intervention group increased from 15.97 to 18.51 (<i>p</i> = 0.001), and the score of sexual dysfunctional beliefs decreased from 33.80 to 24.86 (<i>p</i> = 0.001). In the control group, the sexual function score decreased from 19.09 to 18.59 (<i>p</i> = 0.032) and the sexual dysfunctional beliefs score increased from 31.83 to 32.18 (<i>p</i> = 0.111).</p><p><strong>Conclusion: </strong>Sexual counseling based on the BETTER model has demonstrated efficacy in promoting sexual function and diminishing sexual dysfunctional beliefs. Consequently, the use of this model in the sexual health counseling of postmenopausal women can be considered.</p><p><strong>Trial registration: </strong>IRCT20150128020854N12; October 12, 2023. Iranian Registry of Clinical Trials: https://irct.behdasht.gov.ir/user/trial/71128/view.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143979099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Psychosomatic and medical experiences of menopause in Chinese women: a social media study.","authors":"Yujie Xu, Shujin Ye, Lan Shi, Zhifen Zhang","doi":"10.1080/13697137.2025.2486047","DOIUrl":"https://doi.org/10.1080/13697137.2025.2486047","url":null,"abstract":"<p><strong>Objective: </strong>Menopause has a significant effect on a woman's quality of life, which leads to physical illnesses and mental stresses. Social media listening (SML) studies reveal the experiences of users, sources of information on disease experiences and health dynamics in populations. The aim of this study was to assess the overview of portraits, complaints, symptom distribution and treatment methods of menopausal women through SML.</p><p><strong>Methods: </strong>An info-surveillance study was conducted wherein the search was performed in the question and answer (Q&A) search and online consultation forums. Using the Python + Scrapy crawl technology tool, the search involved single or combined keywords related to menopause, including population, diagnosis, symptom, treatment and treatment comparison.</p><p><strong>Results: </strong>Data were extracted from three menopause-related Q&A search platforms and 15 online consultation forums. Menstrual disorders, menopausal symptoms, and menopausal examination and treatment were the high-frequency keywords while irritability, insomnia and hot flashes were the most commonly mentioned symptoms. A total of 76.62% of menopausal women had a willingness for tier 3 hospitals, with gynecology being the most preferred department chosen by the majority. Among the 359 women reporting hormone treatment to be effective, 90.96% women showed an improvement in symptoms, and the rest had improvement in emotions, various improvements and overall improvement.</p><p><strong>Conclusion: </strong>The results of this SML study indicate that menopausal women in China have a strong urge for menopause-related knowledge but are not well informed. Thus, there is a need for science popularization to sensitize menopausal women to choose the right department, and explore the long-term management of menopause and menopausal hormone therapy.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-10"},"PeriodicalIF":2.9,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143975142","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Menopause, women and the workplace.","authors":"Karen Walker-Bone, Susan Davis","doi":"10.1080/13697137.2025.2480591","DOIUrl":"10.1080/13697137.2025.2480591","url":null,"abstract":"<p><p>This invited review is a synthesis of a plenary lecture presented at International Menopause Society Conference in Melbourne 2024. The focus was to set the historic context within which research about women in the workplace must be approached. It is exciting for occupational health researchers to see expansion of the evidence about health and work but we urge menopause and work researchers to collaborate with occupational health colleagues. The growing literature suggests that most women do not experience problems coping with their menopause in the workplace. Most research, however, fails to consider any workplace factors or even the nature of the job women are needing to do. Where studies have focused on occupational groups, they have focused on nurses or other professional/leadership groups. So far, it appears that women's ability to cope is influenced by the number of symptoms, severity of symptoms, and workplace and personal psychosocial factors. However, the problems with coping may be greater for disadvantaged women doing less well-paid work with less flexibility and autonomy. The same women probably have less access to appropriate advice, treatment and support. Researchers must focus on women at highest risk and take a nuanced approach to optimize support without increasing gender-based discrimination.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143810592","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Experiences of hot flashes, urinary incontinence and mood among South Asian American women: the MASALA study.","authors":"Xiru Lyu, Alison J Huang, Alexa V Kelman, Riva Tauman, Alka M Kanaya, Galit Levi Dunietz","doi":"10.1080/13697137.2025.2480584","DOIUrl":"10.1080/13697137.2025.2480584","url":null,"abstract":"<p><strong>Objective: </strong>This study aimed to characterize menopause timing, type (natural or surgical) and symptoms in US-based South Asian women.</p><p><strong>Method: </strong>The study included 405 women of South Asian descent aged between 43 and 78 years who participated in the Mediators of Atherosclerosis in South Asians Living in America (MASALA) study. Menopause experiences were assessed with structured questionnaires. The study described sociodemographic, health and lifestyle characteristics and menopause symptoms by menopause stage, type (natural or surgical) and timing, and tested for differences using chi-square and Fisher's exact tests.</p><p><strong>Results: </strong>Most women (92%) were postmenopausal, and 7% reported surgical menopause. The mean recalled age at natural menopause was 48 years, and the median recalled age was 49 years. Nearly a third of women experienced premature/early menopause (age ≤45 years). Overall, women reported hot flashes of any intensity (from mild to extremely bothersome) in the past month (30%), urinary incontinence in the past 12 months (37%) and depressive symptoms (15%). Menopause symptoms varied by menopause timing and type (natural vs. surgical). Particularly, the point prevalence of bothersome hot flashes of any intensity in the past month, urinary leakage in the past 12 months and depressive symptoms in the past week was 28%, 37% and 14%, respectively, for women who had natural menopause, and 40%, 48% and 20%, respectively, for surgical menopause.</p><p><strong>Conclusion: </strong>Women of South Asian ancestry reported an earlier recalled age at natural menopause than the average age of 52 years reported in the USA. The burden of hot flashes of any intensity, urinary and mood disturbances suggested distinct postmenopause experiences.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-8"},"PeriodicalIF":2.9,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143771684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}