Juan Enrique Blümel, Maria Soledad Vallejo, Peter Chedraui, Socrates Aedo, Marcio Alexandre Hipolito Rodrigues, Carlos Salinas, Konstantinos Tserotas, Andres Calle, Maribel Dextre, Alejandra Elizalde, Carlos Escalante Gomez, Gustavo Gómez-Tabares, Álvaro de Jesus Monterrosa-Castro, Maria T Espinoza, Monica Ñañez, Eliana Ojeda, Claudia Rey, Doris Rodríguez-Vidal
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Sociodemographic, clinical and anthropometric data were collected, and cognition was assessed using the Montreal Cognitive Assessment (MoCA) tool in 722 postmenopausal women.</p><p><strong>Results: </strong>The mean age, body mass index (BMI) and years of education of the cohort were 56.9 years, 26.8 kg/m<sup>2</sup> and 13.6 years, respectively. Women with cognitive impairment, compared to those without, had a higher BMI (27.8 ± 5.9 vs. 26.6 ± 4.9 kg/m<sup>2</sup>, <i>p =</i> 0.037), had more children (3.1 ± 2.4 vs. 2.5 ± 1.7, <i>p =</i> 0.023), experienced more severe menopausal symptoms (56.3% vs. 31.9%, <i>p</i> < 0.001) and presented more comorbidities (60.0% vs. 43.8%, <i>p =</i> 0.006). They also had fewer years of study (10.8 ± 5.1 vs. 13.9 ± 4.9 years, <i>p =</i> 0.001), were less physically active (35.0% vs. 49.1%, <i>p =</i> 0.018) and were less likely to use menopausal hormone therapy (MHT) (11.3% vs. 28.8%, <i>p =</i> 0.001). In binary logistic regression analysis, BMI ≥ 35.0 kg/m<sup>2</sup> (odds ratio [OR] 2.27, 95% confidence interval [CI] 1.08-4.76) and severe menopausal symptoms (OR 2.10, 95% CI 1.29-3.43) were associated with cognitive impairment. In the model, factors related to lower risk were ever use of MHT (OR 0.44, 95% CI 0.21-0.92) and having more years of education (OR 0.38, 95% CI 0.20-0.64).</p><p><strong>Conclusion: </strong>Severe obesity and severe menopausal symptoms increased the risk of cognitive impairment in postmenopausal women, while higher education and ever use of MHT were protective factors.</p>","PeriodicalId":10213,"journal":{"name":"Climacteric","volume":" ","pages":"1-6"},"PeriodicalIF":2.9000,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Severe obesity and menopause symptoms are associated with cognitive impairment in postmenopausal women from Latin America.\",\"authors\":\"Juan Enrique Blümel, Maria Soledad Vallejo, Peter Chedraui, Socrates Aedo, Marcio Alexandre Hipolito Rodrigues, Carlos Salinas, Konstantinos Tserotas, Andres Calle, Maribel Dextre, Alejandra Elizalde, Carlos Escalante Gomez, Gustavo Gómez-Tabares, Álvaro de Jesus Monterrosa-Castro, Maria T Espinoza, Monica Ñañez, Eliana Ojeda, Claudia Rey, Doris Rodríguez-Vidal\",\"doi\":\"10.1080/13697137.2025.2491637\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>This study aimed to evaluate the association between obesity and cognitive impairment.</p><p><strong>Methods: </strong>This study is a sub-analysis of an observational, cross-sectional study in nine Latin American counties. 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引用次数: 0
摘要
目的：探讨肥胖与认知功能障碍的关系。方法：本研究是对拉丁美洲9个国家的一项观察性横断面研究的亚分析。收集722名绝经后妇女的社会人口学、临床和人体测量数据，并使用蒙特利尔认知评估（MoCA）工具评估认知能力。结果：队列平均年龄56.9岁，体重指数（BMI） 26.8 kg/m2，受教育年限13.6年。与没有认知障碍的妇女相比，有认知障碍的妇女有更高的BMI(27.8±5.9比26.6±4.9 kg/m2, p = 0.037)，有更多的孩子（3.1±2.4比2.5±1.7,p = 0.023），经历更严重的更年期症状（56.3%比31.9%,p = 0.006）。她们的研究年限也较短（10.8±5.1年对13.9±4.9年，p = 0.001），体力活动较少（35.0%对49.1%,p = 0.018），较少使用绝经期激素治疗（MHT）（11.3%对28.8%,p = 0.001）。在二元logistic回归分析中，BMI≥35.0 kg/m2（比值比[OR] 2.27, 95%可信区间[CI] 1.08-4.76）和严重的更年期症状（OR 2.10, 95% CI 1.29-3.43）与认知功能障碍相关。在模型中，与低风险相关的因素是曾经使用过MHT （OR 0.44, 95% CI 0.21-0.92）和受过更多教育（OR 0.38, 95% CI 0.20-0.64）。结论：严重的肥胖和严重的更年期症状增加了绝经后妇女认知功能障碍的风险，而高学历和曾经使用过MHT是保护因素。
Severe obesity and menopause symptoms are associated with cognitive impairment in postmenopausal women from Latin America.
Objective: This study aimed to evaluate the association between obesity and cognitive impairment.
Methods: This study is a sub-analysis of an observational, cross-sectional study in nine Latin American counties. Sociodemographic, clinical and anthropometric data were collected, and cognition was assessed using the Montreal Cognitive Assessment (MoCA) tool in 722 postmenopausal women.
Results: The mean age, body mass index (BMI) and years of education of the cohort were 56.9 years, 26.8 kg/m2 and 13.6 years, respectively. Women with cognitive impairment, compared to those without, had a higher BMI (27.8 ± 5.9 vs. 26.6 ± 4.9 kg/m2, p = 0.037), had more children (3.1 ± 2.4 vs. 2.5 ± 1.7, p = 0.023), experienced more severe menopausal symptoms (56.3% vs. 31.9%, p < 0.001) and presented more comorbidities (60.0% vs. 43.8%, p = 0.006). They also had fewer years of study (10.8 ± 5.1 vs. 13.9 ± 4.9 years, p = 0.001), were less physically active (35.0% vs. 49.1%, p = 0.018) and were less likely to use menopausal hormone therapy (MHT) (11.3% vs. 28.8%, p = 0.001). In binary logistic regression analysis, BMI ≥ 35.0 kg/m2 (odds ratio [OR] 2.27, 95% confidence interval [CI] 1.08-4.76) and severe menopausal symptoms (OR 2.10, 95% CI 1.29-3.43) were associated with cognitive impairment. In the model, factors related to lower risk were ever use of MHT (OR 0.44, 95% CI 0.21-0.92) and having more years of education (OR 0.38, 95% CI 0.20-0.64).
Conclusion: Severe obesity and severe menopausal symptoms increased the risk of cognitive impairment in postmenopausal women, while higher education and ever use of MHT were protective factors.
期刊介绍：
Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women.
Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments.
The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.
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