Burden, trends and projections of low bone mineral density in premenopausal/postmenopausal women.

IF 2.9 4区医学 Q1 OBSTETRICS & GYNECOLOGY

Climacteric Pub Date : 2025-06-18 DOI:10.1080/13697137.2025.2514026

Jun Liao, Yide Wang, Reyla Turson, Rui Fang

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引用次数: 0

Abstract

Objectives: Low bone mineral density (LBMD) significantly contributes to global morbidity and mortality, especially in postmenopausal women. However, its burden in premenopausal women remains underrecognized. This study evaluated the global burden, temporal trends and future projections of LBMD-related outcomes.

Methods: Data were obtained from the Global Burden of Disease 2021 dataset covering 204 countries. Premenopausal and postmenopausal women from 1990 to 2021 were included. Incidence, mortality and disability-adjusted life years (DALYs) were extracted, and age-standardized rates were calculated. The study explored demographic and epidemiologic changes, applied inequality indices and employed a Bayesian Markov chain Monte Carlo model to forecast trends through 2035.

Results: Between 1990 and 2021, LBMD-related mortality rose by 27.39% (95% uncertainty interval [UI] 16.83-39.69) among premenopausal women and 138.73% (95% UI 98.45-186.25) among postmenopausal women. In 2021, the postmenopausal age-standardized rate (27.92 per 100,000) was 63.5 times higher than that of premenopausal women (0.44 per 100,000). By 2035, although rates may decline, overall deaths and DALYs will likely increase due to population growth and aging.

Conclusion: Despite decreasing standardized rates, the absolute burden of LBMD continues to grow. Early screening and targeted prevention, especially for postmenopausal and underrecognized premenopausal women, is crucial to lessen its global impact.

查看原文本刊更多论文

绝经前/绝经后妇女低骨密度的负担、趋势和预测。

目的：低骨密度（LBMD）是全球发病率和死亡率的重要因素，尤其是绝经后妇女。然而，其对绝经前妇女的影响仍未得到充分认识。本研究评估了lbmd相关结果的全球负担、时间趋势和未来预测。方法：数据来自涵盖204个国家的《2021年全球疾病负担》数据集。包括1990年至2021年的绝经前和绝经后妇女。提取发病率、死亡率和残疾调整生命年（DALYs），并计算年龄标准化率。该研究探讨了人口和流行病学的变化，应用了不平等指数，并采用贝叶斯马尔可夫链蒙特卡洛模型预测了到2035年的趋势。结果：1990年至2021年间，绝经前妇女lbmd相关死亡率上升27.39%(95%不确定区间[UI] 16.83-39.69)，绝经后妇女lbmd相关死亡率上升138.73% （95% UI为98.45-186.25）。2021年，绝经后年龄标准化率（27.92 / 10万）是绝经前妇女（0.44 / 10万）的63.5倍。到2035年，尽管死亡率可能下降，但由于人口增长和老龄化，总死亡率和伤残调整生命年可能会增加。结论：尽管标准化率有所下降，但LBMD的绝对负担仍在继续增加。早期筛查和有针对性的预防，特别是对绝经后和未被充分认识的绝经前妇女，对于减轻其全球影响至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.