Complementary therapies for women with premature ovarian insufficiency: a systematic literature review to inform the 2024 update of the ESHRE/ASRM/IMS/CRE-WHiRL guidelines on premature ovarian insufficiency.

IF 3.2 4区医学 Q1 OBSTETRICS & GYNECOLOGY

Climacteric Pub Date : 2025-07-28 DOI:10.1080/13697137.2025.2530441

Alison Maunder, Nathalie Vermeulen, Amanda J Vincent, Nick Panay, Carolyn Ee

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引用次数: 0

Abstract

Objective: Premature ovarian insufficiency (POI) is associated with reduced quality of life and increased health risks. While hormone therapy (HT) is standard treatment, some women seek other options to treat its sequelae. This review explores the role of complementary therapies for POI.

Method: A systematic search of four databases up to January 2024 identified randomized controlled trials, systematic reviews, meta-analyses and umbrella reviews that examined the use of complementary therapies by women with POI. Outcomes included menopausal symptoms, gonadotropins, antral follicle count, ovarian volume and quality of life. Study quality was evaluated using Cochrane Risk of Bias and A MeaSurement Tool to Assess systematic Reviews (AMSTAR 2).

Results: The search identified 1869 citations, with nine studies meeting the inclusion criteria. Findings suggest that Chinese herbal medicine and acupuncture may alleviate menopausal symptoms and regulate gonadotropins in women with POI, although evidence is very limited. There is insufficient evidence for other complementary therapies for POI.

Conclusion: While Chinese herbal medicine may improve menopausal symptoms, there is insufficient evidence specific to POI. There is a clear need for additional and rigorous research on the efficacy and safety of complementary therapies for POI. Evidence does not support complementary medicines as replacements for HT.

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卵巢早衰女性的补充治疗：一项系统的文献综述，为2024年更新的ESHRE/ASRM/IMS/CRE-WHiRL卵巢早衰指南提供信息。

目的：卵巢功能不全（POI）与生活质量下降和健康风险增加有关。虽然激素疗法（HT）是标准的治疗方法，但一些女性寻求其他选择来治疗其后遗症。这篇综述探讨了补充疗法在POI中的作用。方法：对截至2024年1月的四个数据库进行系统检索，确定了随机对照试验、系统评价、荟萃分析和总括性评价，这些综述检查了POI女性使用补充疗法的情况。结果包括更年期症状、促性腺激素、窦卵泡计数、卵巢体积和生活质量。采用Cochrane偏倚风险和评估系统评价的测量工具（AMSTAR 2）对研究质量进行评价。结果：检索到1869条引用，其中9项研究符合纳入标准。研究结果表明，尽管证据非常有限，但中药和针灸可以缓解POI妇女的更年期症状并调节促性腺激素。对于POI的其他补充疗法尚无足够的证据。结论：虽然中草药可以改善更年期症状，但针对POI的证据不足。显然需要对POI补充疗法的有效性和安全性进行额外和严格的研究。没有证据支持补充药物替代激素疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Climacteric 医学-妇产科学

CiteScore

1.70

自引率

7.10%

发文量

审稿时长

1 months

期刊介绍： Climacteric is the official journal of the International Menopause Society (IMS). As an international peer-reviewed journal it publishes original research and reviews of all aspects of aging in women. Climacteric was founded by the IMS in 1998 and today has become a leading journal in the publication of peer-reviewed papers on the menopause, climacteric and mid-life health. Topics covered include endocrine changes, symptoms attributed to the menopause and their treatment, hormone replacement and alternative therapies, lifestyles, and the counselling and education of peri- and postmenopausal women. Climacteric, published bimonthly, also features regular invited reviews, editorials and commentaries on recent developments. The editorial review board of Climacteric includes leading scientific and clinical experts in the field of midlife medicine and research and is headed by its Editor-in-Chief, Professor Rod Baber of Australia. He and his team of Associate Editors act independently to set a clear editorial policy, co-ordinate peer review, and ensure a rapid response to submitted papers.