Jonas Mortier, Christian V. Stevens and Thomas S. A. Heugebaert
{"title":"Electrochemical hydrocarboxylation of styrene with CO2 in continuous flow†","authors":"Jonas Mortier, Christian V. Stevens and Thomas S. A. Heugebaert","doi":"10.1039/D5RE00162E","DOIUrl":"https://doi.org/10.1039/D5RE00162E","url":null,"abstract":"<p >This study demonstrates the advantages of an electrochemical continuous flow cell regarding the β-hydrocarboxylation of styrene. An efficient continuous flow method was developed, obtaining high yields of carboxylic acid with a very low residence time, however still maintaining high selectivity.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 7","pages":" 1455-1460"},"PeriodicalIF":3.4,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/re/d5re00162e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472737","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Caiyun Gao, Jie Zhang, Xiangli Liu, Shipeng Chen, Dong Li and Fei Jin
{"title":"Carbide slag modified into a thermochemical energy storage material via a dual-effect modification method†","authors":"Caiyun Gao, Jie Zhang, Xiangli Liu, Shipeng Chen, Dong Li and Fei Jin","doi":"10.1039/D5RE00110B","DOIUrl":"https://doi.org/10.1039/D5RE00110B","url":null,"abstract":"<p >In this study, a dual-effect modification method for carbide slag modification into a thermochemical energy storage material was proposed. Results showed that the optimally formulated energy storage material CSMn10 contained CaO, Mn<small><sub>2</sub></small>O<small><sub>3</sub></small> and CaMnO<small><sub>3</sub></small> as the main components, which not only inhibited the sintering of calcium oxide grains in the cycling process but also enhanced the alkalinity of the material. These components also promoted the generation of oxygen vacancies, which were favorable for the carbonation reaction. After 20 cycles, the energy storage density of CSMn10 was 1508.23 kJ kg<small><sup>−1</sup></small>, and its average solar absorptivity was as high as 72.99%, which was 7.19 times higher than that of the unmodified calcium carbide slag (CS), significantly enhancing the cycling stability and light-absorbing ability of the material.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 10","pages":" 2252-2263"},"PeriodicalIF":3.1,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pengxiang Zhang, Jianfei Xi, Shuang Li, Guoqing Yang, Yunjun Wang, Yinggui Zhou and Jie Cai
{"title":"A comprehensive numerical analysis of NO generation routes and combustion characteristics with varying strain rates in methane/n-heptane dual fuel flames","authors":"Pengxiang Zhang, Jianfei Xi, Shuang Li, Guoqing Yang, Yunjun Wang, Yinggui Zhou and Jie Cai","doi":"10.1039/D5RE00181A","DOIUrl":"https://doi.org/10.1039/D5RE00181A","url":null,"abstract":"<p >The influence of strain rate on the combustion characteristics and routes of NO formation in methane/<em>n</em>-heptane dual-fuel engines was scrutinized in this research, utilizing a counterflow flame model. The insights gleaned from this study provide valuable theoretical guidance for a more profound comprehension of the NO formation mechanism, thereby facilitating the enhancement and optimization of natural gas–diesel dual-fuel engines. The findings reveal that with an increasing strain rate, the peak flame temperature initially exhibits a slight increase followed by a decrease, while the heat release rate experiences a significant surge. Concurrently, the high-temperature region and the distribution areas of the main species and intermediate products are markedly reduced. The NO emission index undergoes initial fluctuations and then demonstrates a consistent decline with the increment of the strain rate, implying that a higher strain rate is conducive to curtailing NO formation. Relative to the enhancing effect of elevated O radical molar fractions on NO formation, the reduction in flame temperature exerts a more pronounced inhibitory influence on the generation of thermal NO. An elevated strain rate also intensifies the production of CH radicals, which in turn, bolsters the formation of prompt NO. Furthermore, an increase in strain rate accelerates the reaction between HCCO and CH<small><sub>2</sub></small> radicals with NO, augmenting NO consumption and enhancing the reduction effect of the reburn route on NO. The contributions of the N<small><sub>2</sub></small>O intermediate route and the NNH intermediate route to NO generation are found to be negligible.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 8","pages":" 1845-1858"},"PeriodicalIF":3.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Ganwen Deng, Liang Li, Chenguang Wang, Haiyong Wang and Yuhe Liao
{"title":"Catalytic transformation of epoxy resin into dicyclohexane†","authors":"Ganwen Deng, Liang Li, Chenguang Wang, Haiyong Wang and Yuhe Liao","doi":"10.1039/D5RE00105F","DOIUrl":"https://doi.org/10.1039/D5RE00105F","url":null,"abstract":"<p >Although thermosetting epoxy resins are widely used high performance polymers in industry, chemical conversion of waste epoxy resins into high value products is hampered by their robust structure. Herein, we developed heterogeneous catalysts containing a hydroprocessing catalyst and solid acid for the chemical transformation of glycidyl end-capped poly(bisphenol A-<em>co</em>-epichlorohydrin) into hydrocarbons (mainly dicyclohexane). The yield of propane-2,2-diyldicyclohexane reached 83.6% at 220 °C after 10 h under the action of cooperative catalysis between Pd/C and HZSM-5. It was proved that Pd/C initiated the reaction and the acidic zeolite assisted further degradation into small oxygen-containing molecules. For the conversion of oxygenates into hydrocarbons, the hydrogenation of unsaturated molecules was achieved using Pd/C, and the acidic zeolite dehydrated the hydrogenation products to remove oxygen. Moreover, the anhydride-cured epoxy resin was converted into propane-2,2-diyldicyclohexane in the presence of Pd/C and HZSM-5 after methanolysis. This work demonstrates that the chemical transformation of waste epoxy resin <em>via</em> heterogeneous catalysis is achievable.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 8","pages":" 1859-1869"},"PeriodicalIF":3.4,"publicationDate":"2025-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680961","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Bavo Vandekerckhove, Stefan Desimpel, Bart Ruttens, Massimo Bocus, Wim Temmerman, Bert Metten, Veronique Van Speybroeck, Thomas S. A. Heugebaert and Christian V. Stevens
{"title":"Direct aminolysis of methyl esters with ammonia in continuous flow through Bayesian optimization†","authors":"Bavo Vandekerckhove, Stefan Desimpel, Bart Ruttens, Massimo Bocus, Wim Temmerman, Bert Metten, Veronique Van Speybroeck, Thomas S. A. Heugebaert and Christian V. Stevens","doi":"10.1039/D5RE00163C","DOIUrl":"https://doi.org/10.1039/D5RE00163C","url":null,"abstract":"<p >Amides play a crucial role in the pharmaceutical, animal health and agrochemical industry. Despite the availability of various catalytic systems and coupling reagents, many methods suffered from long reaction times and poor atom economy. The direct synthesis of primary amides remained particularly challenging due to the limited availability of suitable nitrogen sources. In this study, continuous flow technology was explored as a process-intensification approach for the direct amidation of methyl esters to produce primary amides. Methanolic ammonia was employed as a nitrogen source to enhance process efficiency while circumventing the limitations of aqueous ammonia and the hazards of gaseous ammonia. Seventeen substrates were screened to assess their aminolysis reactivity under these conditions. As a proof of concept, methyl picolinate was selected for continuous flow optimization using Bayesian optimization. Therefore, a custom-designed high-pressure, high-temperature continuous flow reactor was utilized to achieve efficient, safe and scalable synthesis (200 °C, 50 bar).</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 8","pages":" 1887-1896"},"PeriodicalIF":3.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/re/d5re00163c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680964","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Giulia Brufani, Maitê Campos, Chiara Lenzi, Luís Adriano Santos do Nascimento, Emilia Paone, Andrea Piazzi, Rita Mazzoni, Luigi Vaccaro and Francesco Mauriello
{"title":"Selective transfer hydrogenation of furfural under continuous flow conditions promoted by the recoverable homogeneous Shvo's catalyst†","authors":"Giulia Brufani, Maitê Campos, Chiara Lenzi, Luís Adriano Santos do Nascimento, Emilia Paone, Andrea Piazzi, Rita Mazzoni, Luigi Vaccaro and Francesco Mauriello","doi":"10.1039/D5RE00176E","DOIUrl":"https://doi.org/10.1039/D5RE00176E","url":null,"abstract":"<p >The continuous-flow application of the homogeneous Shvo's catalyst for the selective transfer hydrogenation of furfural to furfuryl alcohol, utilizing biobased 2-methyltetrahydrofuran as the reaction medium and 2-propanol as a stoichiometric hydrogen donor is reported for the first time. The homogeneous catalyst demonstrated excellent recyclability, maintaining high performance over at least five consecutive reaction cycles. This process represents an efficient and waste-minimized strategy for the reductive catalytic valorization of biomass-derived furfural under continuous-flow conditions, as validated by a comprehensive green metrics assessment.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 6","pages":" 1227-1232"},"PeriodicalIF":3.4,"publicationDate":"2025-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/re/d5re00176e?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144148236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Olga C. Dennehy, Denis Lynch, U. B. Rao Khandavilli, Simon E. Lawrence, Stuart G. Collins, Anita R. Maguire and Humphrey A. Moynihan
{"title":"Formation of the E-isomer as an impurity in the optimized flow synthesis of a Z-α-thio-β-chloroacrylamide; E/Z photoisomerization in batch and flow, and solid state characterization of both isomers†","authors":"Olga C. Dennehy, Denis Lynch, U. B. Rao Khandavilli, Simon E. Lawrence, Stuart G. Collins, Anita R. Maguire and Humphrey A. Moynihan","doi":"10.1039/D5RE00137D","DOIUrl":"https://doi.org/10.1039/D5RE00137D","url":null,"abstract":"<p > <em>N</em>-(4-Methylphenyl)-<em>Z</em>-3-chloro-2-(phenylthio)propenamide (<strong><em>Z</em>-3</strong>), which is valuable as a reactive substrate for a range of synthetic transformations, can be obtained by a three-step process involving both batch and flow methodologies. Compound <strong><em>Z</em>-3</strong> was isolated as a crystalline material of high purity, however, the <em>E</em>-isomer, <strong><em>E</em>-3</strong>, was found to form in solid samples of <strong><em>Z</em>-3</strong> material during storage. Increased ratios of <strong><em>E</em>-3</strong> and pure isolated samples were obtained by photoisomerization in batch and flow modes, with the flow process being optimal in terms of process time. Crystal structure analysis of both the <em>Z</em> and <em>E</em> isomers highlighted key differences in molecular conformations and supramolecular interactions with greater deviation from planarity evident in <strong><em>E</em>-3</strong> relative to <strong><em>Z</em>-3</strong>. Analysis of samples of <strong><em>Z</em>-3</strong> by PXRD and DSC after recrystallization from a variety of solvents gave data consistent with the determined crystal structure of <strong><em>Z</em>-3</strong>.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 8","pages":" 1878-1886"},"PeriodicalIF":3.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/re/d5re00137d?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Acidic ionic liquid-decorated covalent organic framework TpPa–SO3H: a reusable solid acid catalyst used for sustainable biodiesel production from low-grade acidic oils","authors":"Xingyi Jia, Wenlei Xie and Heping Li","doi":"10.1039/D4RE00501E","DOIUrl":"https://doi.org/10.1039/D4RE00501E","url":null,"abstract":"<p >Hierarchical porous solid catalysts, with features such as large surface area, low mass transfer resistance, and high accessibility of active sites, have emerged as ideal catalysts for promoting large biomass molecule-involving reactions. In this study, an acidic ionic liquid [PrSO<small><sub>3</sub></small>HMIM] [HSO<small><sub>4</sub></small>] loaded covalent organic framework (COF) solid catalyst (<em>x</em>AIL@TpPa–SO<small><sub>3</sub></small>H) was developed as an effective and recoverable catalyst for the efficient production of biodiesel. The solid catalysts featuring hierarchical porous structure and high surface acidities effectively improved the mass diffusion rate of oily macromolecules and easy accessibility of active sites. This catalyst demonstrated enhanced activities in the transesterification of triglycerides and esterification of free fatty acids (FFAs) simultaneously, which could achieve one-step production of biodiesel from low-grade acidic oils. Under the optimal conditions of a methanol to soybean oil molar ratio of 30 : 1, 10 wt% of catalyst loading (relative to the used soybean oil), and reaction temperature of 120 °C for 8 h, an oil conversion of 93.9% and full FFA conversion could be concurrently attained by adopting this developed catalyst. Kinetic studies have identified that the apparent activation energy <em>E</em><small><sub>a</sub></small> of the oil transesterification was 45.36 kJ mol<small><sup>−1</sup></small>. Additionally, this catalyst exhibited satisfactory acid- and water-resistance even with an FFA level of 40% and water content of 4%, and after four times of reuse, over 80% oil conversion could still be attained, hereby posing its high potential for sustainable and green production of biodiesel particularly with low-grade acidic oils as feedstocks.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 8","pages":" 1932-1948"},"PeriodicalIF":3.4,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Robbe Bryssinck, Gregory James Smith, Colin O'Modhrain, Tom Van Assche, Georgi Trenchev and Annemie Bogaerts
{"title":"Performance of a gliding arc plasmatron pilot reactor with an integrated carbon bed and recirculation for upscaled CO2 conversion†","authors":"Robbe Bryssinck, Gregory James Smith, Colin O'Modhrain, Tom Van Assche, Georgi Trenchev and Annemie Bogaerts","doi":"10.1039/D5RE00190K","DOIUrl":"https://doi.org/10.1039/D5RE00190K","url":null,"abstract":"<p >In this work, we investigated the performance of a multi-reactor gliding arc plasmatron (MRGAP) pilot reactor with an integrated carbon bed and recirculation. Experimentally, we varied the following parameters: carbon bed position, total flow rate, recirculation and a semi-continuous feeding system. The optimum operating conditions were found to be with the carbon bed located closest to the reactor outlets (35 mm) at a flow rate of 50 L min<small><sup>−1</sup></small> with a semi-continuous carbon feed. Under these conditions, we obtain a maximum CO<small><sub>2</sub></small> conversion of 20%, corresponding to a conversion rate of 1068 g h<small><sup>−1</sup></small> and a CO concentration of 33 vol% at the outlet. The plug-power based energy cost (EC) for these optimum conditions was 5.8 MWh t<small><sub>CO</sub></small><small><sup>−1</sup></small> (1.2 MJ mol<small><sub>CO<small><sub>2</sub></small></sub></small><small><sup>−1</sup></small>). When implementing a gas recirculation stage, the CO<small><sub>2</sub></small> conversion increases from 10.3% to 12.7%, but the EC rises from 10.9 MWh t<small><sub>CO</sub></small><small><sup>−1</sup></small> to 13.7 MWh t<small><sub>CO</sub></small><small><sup>−1</sup></small>. To complement the experimental work, we also developed a 2D model of the post-plasma chamber, coupled to a simple model for the plasma reactor. The model enables further insights into the effect of the carbon bed position and temperature on the performance, and confirms that when the carbon bed is positioned closer to the inlets, the performance increases. Both experimental and modelling results indicate that the integration of a carbon bed into an industrial scale plasma reactor is viable and can improve both the CO<small><sub>2</sub></small> conversion and energy metrics.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 8","pages":" 1910-1923"},"PeriodicalIF":3.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680966","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tom L. Roberts, Jonathan P. Dolan, Gavin J. Miller, Marcelo A. D. Lima and Sebastian C. Cosgrove
{"title":"A modular, reusable biocatalytic flow system for UDP-GlcNAc production†","authors":"Tom L. Roberts, Jonathan P. Dolan, Gavin J. Miller, Marcelo A. D. Lima and Sebastian C. Cosgrove","doi":"10.1039/D5RE00127G","DOIUrl":"10.1039/D5RE00127G","url":null,"abstract":"<p >We report here the continuous flow synthesis of a high-value sugar nucleotide. Immobilisation of enzymes onto solid carriers permitted transfer of the biocatalysts into packed bed reactors to realise a continuous biocatalytic platform for the synthesis of uridine diphosphate <em>N</em>-acetylglucosamine (UDP-GlcNAc) on 100 mg scale, with capacity for multiple reuses. The modular continuous flow approach described here represents a significant, up to 11-fold, improvement in space time yield (STY) when compared to batch studies, along with preventing product induced enzyme inhibition, reducing the need for an additional enzyme to break down inorganic pyrophosphate (PPi). The modular nature of the system has also allowed tailored conditions to be applied to each enzyme, overcoming issues relating to thermal stability. This development presents a platform approach towards a more efficient, continuous synthesis of important glycan targets including glycoproteins, specific oligosaccharide sequences and glycosylated drug targets.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 6","pages":" 1221-1226"},"PeriodicalIF":3.4,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12079181/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144092221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}