Reaction Chemistry & Engineering最新文献

{"title":"Reactor intensification on glycerol-to-acrylic acid conversion: a modelling study†","authors":"Prashant Pawanipagar, Kamran Ghasemzadeh, Carmine D'Agostino and Vincenzo Spallina","doi":"10.1039/D4RE00481G","DOIUrl":"https://doi.org/10.1039/D4RE00481G","url":null,"abstract":"<p >This work presents a numerical analysis for glycerol dehydration &amp; acrolein oxidation to produce acrylic acid and determine the optimal process conditions combining computational fluid dynamics (CFD) with response surface methodology (RSM) techniques. For glycerol dehydration, optimum conditions are found at 623 K, 5731.6 h<small>⁻¹</small> GHSV, and a glycerol mass fraction of 0.32, resulting in a glycerol conversion of 94.2% and an acrolein selectivity of 79.6%. Further, the simulations with optimized conditions for two proposed configurations have insignificant glycerol conversion and acrolein selectivity suggesting that alternative reactor configurations have limited improvement. In the case of the acrolein selective oxidation process, an optimum temperature of 583.5 K, a GHSV of 1600 h<small>⁻¹</small>, and an oxygen-to-acrolein molar ratio of 5.73 result in an acrylic acid yield and a selectivity of 80.9% and 87.5%, respectively. In the case of a membrane reactor with distributed oxygen feeding, the acrylic acid yield reached 85.9% and it exhibits a remarkable selectivity of 97.1%.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 8","pages":" 1812-1827"},"PeriodicalIF":3.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/re/d4re00481g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680946","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"New dispersible and low-melting cellulose ester produced with molten adipic acid as a solvent, reagent and catalyst, and its application to improve the mechanical properties of PLA†","authors":"Mariafrancesca Baratta, Fabrizio Olivito, Cataldo Simari, Wan Abd Al Qadr Imad Wan-Mohtar, Isabella Nicotera, Fiore Pasquale Nicoletta, Giovanni De Filpo and Giovanni Golemme","doi":"10.1039/D5RE00080G","DOIUrl":"https://doi.org/10.1039/D5RE00080G","url":null,"abstract":"<p >The synthesis of a new cellulose ester (CE) from microcrystalline cellulose (MCC) and adipic acid is described. The solvent-free reaction was carried at 155 °C, slightly above the melting point of adipic acid. The molten acid is both the reactant and the Brønsted acid catalyst in this reaction. Cellulose adipate is highly crystalline and the modification of the XRD powder pattern with respect to MCC indicates that the spatial arrangement of the pristine cellulose Iβ and its hydrogen bonding network have drastically changed. According to TGA and XRD, esterified cellulose surrounds a core of intact MCC (25% by weight), however, the new cellulose adipate material has a melting point of 153 °C and is dispersable in chlorinated solvents. The composites with PLA were prepared by the solvent casting method. The best results were obtained using 3 wt% of the cellulose ester, with a maximum elongation increased by 59%, and a reduction of the tensile strength of 25% only. The SEM images of the best PLA composite show the absence of the cracks found in the PLA films. This work demonstrates how value-added materials can be prepared from renewable and readily available resources through green and sustainable technologies.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 7","pages":" 1615-1626"},"PeriodicalIF":3.4,"publicationDate":"2025-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/re/d5re00080g?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472766","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reaction kinetics for the synthesis of an anti-cancer drug (adavosertib) precursor†","authors":"Matthew Blair, Mazaher M. Chalchooghi, Robert J. Cox and Dimitrios I. Gerogiorgis","doi":"10.1039/D5RE00082C","DOIUrl":"https://doi.org/10.1039/D5RE00082C","url":null,"abstract":"<p >The development of kinetic models which can accurately describe drug synthesis reactions is an important part of process design in the pharmaceutical industry. Correctly identifying these models can be difficult, since the reaction pathways used to manufacture new pharmaceutical compounds are often extremely complex. Consequently, many kinetic modelling and parameter estimation tools have been developed in recent years to allow drug manufacturers to test and compare a variety of reaction models before selecting the one which provides the best predictions. The present paper employs a multistart parameter estimation code (in MATLAB®) to parameterise a range of kinetic models describing the synthesis of a key intermediate required for the production of a new anti-cancer drug, Adavosertib (AZD1775). Furthermore, the Akaike and Bayesian Information Criteria are used to rank these models based upon their complexity and fidelity to reflect real-world experimentation.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 10","pages":" 2356-2372"},"PeriodicalIF":3.1,"publicationDate":"2025-04-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/re/d5re00082c?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145121345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A PLC based semi-automated extraction chromatographic separation system for the isolation of medical grade no-carrier-added lutetium-177 for targeted cancer therapy†","authors":"Dheeraj Kumar, Aaditya Shah, Varun Nair, B. K. Tiwary, N. C. Joseph, Abhishek K. Sharma, Arpit Mitra, Navin Sakhare, Sanjeev Kumar, Chanda Arjun, K. V. V. Nair, Anupam Mathur, Sudipta Chakraborty, Usha Pandey, Ameya Puranik, Archi Agrawal and Venkatesh Rangarajan","doi":"10.1039/D4RE00574K","DOIUrl":"https://doi.org/10.1039/D4RE00574K","url":null,"abstract":"&lt;p &gt;Extensive clinical deployment of lutetium-177 (&lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu) radiopharmaceuticals for targeted cancer therapy has led to an increased demand of &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu-radionuclides all over the world. Since most of the clinically established targeted cancer therapies involve receptor targeting peptides, enzyme inhibitors or antibodies, the use of high specific activity &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu is necessary to prepare &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu complexes in high molar activity to obtain maximum efficacy of treatment. Therefore, there is an immense interest in the production of clinical grade no carrier added (NCA) &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu globally. While carrier added &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu can be produced by the neutron activation of an enriched &lt;small&gt;&lt;sup&gt;176&lt;/sup&gt;&lt;/small&gt;Lu target, NCA&lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu is produced by neutron activation of an enriched &lt;small&gt;&lt;sup&gt;176&lt;/sup&gt;&lt;/small&gt;Yb target &lt;em&gt;via&lt;/em&gt; the &lt;small&gt;&lt;sup&gt;176&lt;/sup&gt;&lt;/small&gt;Yb (n, γβ) &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu reaction. The present work describes a semi-automated extraction chromatography-based modular separation system, which can be conveniently adopted for rapid isolation of medical grade NCA &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu from the neutron irradiated enriched &lt;small&gt;&lt;sup&gt;176&lt;/sup&gt;&lt;/small&gt;Yb target. The separation module is based on multistage extraction chromatography using LN2 and DGA resins (3 stage each). Herein, we demonstrate effective utilization of this system to separate &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu from the irradiated enriched &lt;small&gt;&lt;sup&gt;176&lt;/sup&gt;&lt;/small&gt;Yb target (+96.4%, 50–150 mg). The process could be completed within a short period of 4–5 h with overall 70–74% (26.6–74.0 GBq) &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu recovery. The HPGe and ICP-AES analysis results for a typical batch indicated Yb impurity below 0.1% in isolated &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu. The &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu specific activity obtained was ∼1.6 GBq mg&lt;small&gt;&lt;sup&gt;−1&lt;/sup&gt;&lt;/small&gt; of lutetium. The NCA &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;LuCl&lt;small&gt;&lt;sub&gt;3&lt;/sub&gt;&lt;/small&gt; obtained by this route qualified all the necessary quality control tests for human use. To demonstrate the clinical utility, the NCA &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;LuCl&lt;small&gt;&lt;sub&gt;3&lt;/sub&gt;&lt;/small&gt; activity was used for the preparation of patient doses each of &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu-DOTA-TATE (7.4 GBq) and &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu-PSMA-617 (7.4 GBq). The 24 h post-therapy SPECT scan of the two cancer patients injected with the respective &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;Lu-radiopharmaceuticals (5.5–7.4 GBq) were in concordance with the corresponding &lt;small&gt;&lt;sup&gt;68&lt;/sup&gt;&lt;/small&gt;Ga-PET scans. The PLC based semi-automated separation system reported herein demonstrates the feasibility of NCA &lt;small&gt;&lt;sup&gt;177&lt;/sup&gt;&lt;/small&gt;LuCl&lt;small&gt;&lt;sub&gt;3&lt;/sub&gt;&lt;/small&gt; production in a short span of time, which can be effectively implemented at the commercial scale fo","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 7","pages":" 1569-1576"},"PeriodicalIF":3.4,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472723","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Proton exchange membrane flow reactor with ozone-treated gas diffusion layers for production of pure H2O2 in aqueous and methanol solutions†","authors":"Takuya Okazaki, Chihiro Tateishi, Kento Shibata, Kazuma Enomoto and Fumiaki Amano","doi":"10.1039/D4RE00634H","DOIUrl":"https://doi.org/10.1039/D4RE00634H","url":null,"abstract":"<p >Electrocatalytic production of pure H<small>₂</small>O<small>₂</small><em>via</em> the two-electron oxygen reduction reaction (2e<small>⁻</small> ORR) in a proton exchange membrane (PEM) flow reactor is an ideal process for on-site and on-demand H<small>₂</small>O<small>₂</small> usage. However, the low selectivity is challenging due to the successive reduction of generated H<small>₂</small>O<small>₂</small> remaining on the electrocatalyst in a membrane electrode assembly with a gas diffusion layer (GDL). This study investigates the selective 2e<small>⁻</small> ORR in an H<small>₂</small>–O<small>₂</small> PEM flow reactor (PEMFR) using a cobalt electrocatalyst with various cathode GDLs to optimize the transport of solvent to recover the generated H<small>₂</small>O<small>₂</small>. The effects of wettability and hydrophobicity were tested using pristine, polytetrafluoroethylene (PTFE) treated, and ozone-treated carbon GDLs under simultaneous water and O<small>₂</small> gas flow. The ozone-treated GDL, with slight hydrophilicity, continuously produced 46 mM H<small>₂</small>O<small>₂</small> (1560 ppm) with a faradaic efficiency (FE) of ∼75% at a current density of 20–30 mA cm<small>⁻²</small>. In contrast, pristine and PTFE-treated GDLs resulted in a low H<small>₂</small>O<small>₂</small> FE below 15%. The ozone-treated GDL on the flow channel side was critical for transporting liquid water to recover the generated H<small>₂</small>O<small>₂</small>. The production of H<small>₂</small>O<small>₂</small> in methanol instead of water also achieved ∼80% FE, without applying energy bias.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 7","pages":" 1638-1646"},"PeriodicalIF":3.4,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydrogenation of nitriles to primary amines with a carbon-coated Ni/NiO@C catalyst under friendly conditions†","authors":"Weidong Liu and Jianguo Liu","doi":"10.1039/D5RE00096C","DOIUrl":"https://doi.org/10.1039/D5RE00096C","url":null,"abstract":"<p >Reusable catalysts based on non-noble metals with broad applicability for nitrile catalytic hydrogenation are key to achieving more sustainable primary amine production. Herein, a simple and efficient carbon-coated non-noble nickel-based catalyst (Ni/NiO@C-600-200-1-H<small>₂</small>O) was developed for the hydrogenation of aromatic substituted nitriles to aromatic substituted amines under relatively mild conditions (120 °C, 10 bar H<small>₂</small>, 4 h). The carbon-coated structure endows the catalyst with excellent anti-agglomeration properties, significantly enhancing its cycling stability. The catalyst exhibits high tolerance toward various functional groups, including halogen, methyl, and methoxy, achieving remarkable conversion rates (over 99%) and product selectivity (up to 98.25%). Additionally, the catalyst's magnetic properties facilitate easy recovery and reuse. When applied to a continuous flow reactor for benzonitrile hydrogenation under optimized conditions, the catalyst demonstrated a conversion rate and selectivity exceeding 99%, with continuous operation lasting up to 31 h.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 7","pages":" 1627-1637"},"PeriodicalIF":3.4,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472767","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synthesis of nitrile-containing reactive phenolphthalein polyaryletherketone and synergistic toughening research on the toughening of epoxy resin—phase structure, mechanical and thermal properties","authors":"Jiawei Liu, Tongjia Zhang, Shoutian Qiu, Lixin Song, Guangyuan Zhou and Honghua Wang","doi":"10.1039/D5RE00084J","DOIUrl":"https://doi.org/10.1039/D5RE00084J","url":null,"abstract":"<p >The introduction of reactive groups capable of participating in epoxy cross-linking into the molecular chains of conventional thermoplastic toughening agents effectively enhances the interfacial compatibility between thermoplastic and thermosetting resins, resulting in a significant improvement in system impact toughness. Building on this approach, this study innovatively incorporates polar nitrile groups into the molecular chains of thermoplastic polyaryletherketone agents containing terminal reactive groups, thereby exploring the synergistic mechanism between reactive and nitrile groups. A systematic investigation is conducted to examine how variations in the nitrile group content and the addition level of the toughening agent influence the toughening effect of epoxy resin. Additionally, the influence of different epoxy system phase structures on mechanical properties is assessed. Experimental results reveal that when the toughening agent PEKCN-OH is added at less than 10 parts per hundred resin (phr), the epoxy system exhibits a sea-island morphology, with the impact strength decreasing with increasing nitrile group content. When no nitrile groups are present (using PEKC-OH resin), the impact strength reaches 23.5 kJ m<small>⁻²</small>, representing a 97% increase compared to the control without the toughening agent. For addition levels exceeding 10 phr, the system transitions to a bicontinuous structure. In this regime, the impact strength initially increases before decreasing as the nitrile group content increases. At a nitrile group content of 50% (using PEKCN-OH-2 resin), the impact strength reaches 25.8 kJ m<small>⁻²</small>, representing a 117% increase. Importantly, the addition of these toughening agents not only prevents a reduction in the service temperature of the epoxy resin but also enhances its thermal stability. In conclusion, the PEKCN-OH developed in this study serves as a highly efficient, easily prepared reactive thermoplastic toughening agent suitable for industrial production. It holds great promise for use in demanding industrial applications, including aerospace, electronics and electrical appliances, and automotive manufacturing. The findings are expected to make significant contributions to material innovation and product performance optimization in these sectors.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 7","pages":" 1539-1550"},"PeriodicalIF":3.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472721","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Simultaneous enzymatic esterification and ester extraction in Pickering emulsions for the recovery of butanol from fermentation broth†","authors":"Yaoyao Feng, Pierre-Louis Carrette, Christine Dalmazzone and Etienne Jourdier","doi":"10.1039/D4RE00625A","DOIUrl":"https://doi.org/10.1039/D4RE00625A","url":null,"abstract":"<p >The recovery of biobutanol from highly diluted aqueous fermentation broth usually suffers from intensive energy consumption. In this study, we developed a Pickering emulsion system stabilized by silica nanoparticles for the rapid and efficient recovery of low concentrations of butanol (&lt;20 g L<small>⁻¹</small>) from fermentation broth in the form of esters. Each droplet in the emulsion system serves as a microreactor for enzymatic esterification of butanol in the water phase, and the ester product is spontaneously extracted to the oil phase, thereby promoting the esterification reaction. The system offers a significantly larger interfacial area and a 2–5 times improvement in reaction rate compared to the biphasic system. Under optimal conditions, the conversion and extraction of butanol from the fermentation broth into butyl butyrate achieved a yield of 79% in the presence of a Pickering emulsion. This study presents a sustainable and efficient approach for the recovery of biobased butanol.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 7","pages":" 1606-1614"},"PeriodicalIF":3.4,"publicationDate":"2025-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://pubs.rsc.org/en/content/articlepdf/2025/re/d4re00625a?page=search","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Multi-stage spiral-type structured catalyst system for direct large-scale methanation of industrial CO2 emissions: a feasibility study†","authors":"Hiroshi Akama, Ryo Watanabe, Priyanka Verma and Choji Fukuhara","doi":"10.1039/D4RE00606B","DOIUrl":"https://doi.org/10.1039/D4RE00606B","url":null,"abstract":"<p >Anthropogenic CO<small>₂</small> emission to the atmosphere has led to severe climate changes and global warming worldwide. The conversion of CO<small>₂</small> into value-added products is an important and promising solution to reduce the atmospheric levels of CO<small>₂</small> and overcome the energy crisis. The CO<small>₂</small> methanation reaction is being explored by many researchers and industries for the fixation of CO<small>₂</small> as a power-to-gas technology. In this report, we have attempted CO<small>₂</small> methanation in the presence of O<small>₂</small> using a lab-scale two-stage type reactor system with Ni and Ru-based spiral-type structured catalysts. Furthermore, the thermodynamic properties of both catalysts were evaluated in the presence and absence of O<small>₂</small>. The combustion of H<small>₂</small> due to the coexistence of O<small>₂</small> promoted methanation even under room temperature conditions and showed excellent methanation performance (conv. 90% &amp; selectivity 100%) for relatively larger amounts (5 L min<small>⁻¹</small>) of gas treatment. Additionally, the heat management for the reactors by adiabatic insulation was found to be effective in improving the catalytic performance and thermodynamic properties.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 7","pages":" 1527-1538"},"PeriodicalIF":3.4,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144472752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Continuous-flow synthesis of special Au–Ag bimetallic nanoparticles and their application for SERS detection of thiram in cherry juice†","authors":"Li Sun, Mingjian Jiang, Yuan Zhi, Hua Zhang, Binlin Dou, Yuejin Shan, Jian Chen and Xiangyang Xu","doi":"10.1039/D5RE00063G","DOIUrl":"https://doi.org/10.1039/D5RE00063G","url":null,"abstract":"<p >Here, using quasi-spherical Ag nanoparticles (NPs) as intermediates, continuous-flow synthesis of special Au–Ag bimetallic nanoparticles is efficiently achieved. Meanwhile, the microstructure evolution of Au–Ag bimetallic NPs is revealed, providing a theoretical reference for the microstructure control of bimetallic NPs. Furthermore, these special Au–Ag bimetallic NPs exhibit excellent performance for the SERS detection of thiram in cherry juice, indicating significant application potential in food safety.</p>","PeriodicalId":101,"journal":{"name":"Reaction Chemistry & Engineering","volume":" 5","pages":" 965-969"},"PeriodicalIF":3.4,"publicationDate":"2025-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143888510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}