Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"To explore the scientific connotation of Fuyang therapy for liver cancer based on mitochondrial function","authors":"Yang Wang ,&nbsp;Bugao Zhou ,&nbsp;Shanshan Li ,&nbsp;Linxin Zheng ,&nbsp;Bohan Cai ,&nbsp;Huiyu Wang ,&nbsp;Sili Li ,&nbsp;Yuhan Lin ,&nbsp;Yanhe Xu","doi":"10.1016/j.prmcm.2025.100709","DOIUrl":"10.1016/j.prmcm.2025.100709","url":null,"abstract":"<div><h3>Background</h3><div>Liver cancer poses a serious threat to human health,and research into its pathogenesis and exploration of treatment strategies have always been major focuses in the medical field.Recent studies have indicated that mitochondrial dysfunction plays a promoting role in the progression of liver cancer,primarily manifested through disruptions in energy metabolism,decreased mitochondrial outer membrane permeability, and dysregulation of calcium ion homeostasis. In traditional Chinese medicine (TCM), “Yang deficiency and Yin excess” is considered the core pathogenesis of liver cancer, and the fundamental treatment principle of “Fuyang Guben” (supporting Yang and reinforcing the root) has been proposed. The mechanism of action may be associated with the improvement of mitochondrial function, however modern research in this area remains relatively limited.</div></div><div><h3>Methods</h3><div>Through theoretical analysis and comprehensive literature review, this paper elucidates the theoretical basis of Fuyang therapy for liver cancer from the perspective of TCM theory,summarizes the specific roles of mitochondrial function in the progression of liver cancer, and systematically reviews recent advances in modern mechanistic research on how Fuyang therapy inhibits the occurrence and development of liver cancer by regulating mitochondrial function.</div></div><div><h3>Results</h3><div>Fuyang therapy can improve mitochondrial function from multiple perspectives,including restoring energy metabolism,regulating membrane permeability, and maintaining calcium homeostasis,thereby inhibiting the proliferation and progression of liver cancer cells.Existing experimental and clinical studies have preliminarily verified the potential efficacy of Fuyang-based formulas in anti-liver cancer treatments and their regulatory mechanisms involving mitochondrial function-related pathways.</div></div><div><h3>Conclusion</h3><div>Fuyang therapy demonstrates both theoretical rationality and experimental support in the treatment of liver cancer.Its anti-liver cancer effects are achieved through the improvement of mitochondrial function,providing new insights for the formulation of TCM-based treatments and mechanistic research on liver cancer.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100709"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363236","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Assessing the efficacy and safety of traditional Chinese medicine for cancer-related fatigue in lung cancer patients: A comprehensive meta-analysis of randomized controlled trials","authors":"Jingya Yang ,&nbsp;Yuxiao Li ,&nbsp;Yurou Li ,&nbsp;Menghuan Song ,&nbsp;Hao Hu ,&nbsp;Carolina Oi Lam Ung","doi":"10.1016/j.prmcm.2025.100683","DOIUrl":"10.1016/j.prmcm.2025.100683","url":null,"abstract":"<div><h3>Background</h3><div>Cancer-related fatigue (CRF) is a persistent condition that significantly impacts the health of lung oncology patients. While the conventional and non-pharmacological therapy for CRF remain uncertain, traditional Chinese medicine (TCM) has become a trending option. This study aimed to assess the efficacy and safety of TCM for CRF in lung cancer from randomized controlled trials (RCTs).</div></div><div><h3>Methods</h3><div>According to PRISMA guidelines, seven databases were searched up to 30 June 2024. Only TCM interventions were eligible in this review. Meta-analysis and network meta-analysis (NMA) were designed to pool outcomes results and compared various TCM interventions. The CONSORT-CHM and Risk of Bias tool were used to evaluate the quality and potential biases.</div></div><div><h3>Results</h3><div>This review included 41 RCTs. Compared with the routine treatment (RT), TCM + RT had significant improved efficacy rate (Risk Ratio (RR) = 1.333, 95 % Confidence Intervals (CI): 1.227 to 1.448, <em>P</em> &lt; 0.01), Karnofsky Performance Status scores (KPS) (Mean Difference (MD) = 7.182, 95 % CI: 4.160 to 10.203, <em>P</em> &lt; 0.01) and Quality of Life Questionnaires-C30 scores (QLQ-30) (MD = 9.186, 95 % CI: 6.707 to 11.665, <em>P</em> &lt; 0.01). Also, TCM + RT showed significance in reducing Piper Fatigue Scale scores (PFS) (MD = -1.145, 95 % CI: -1.452 to -0.838, <em>P</em> &lt; 0.01), Cancer-Fatigue Scale scores (MD = -6.411; 95 %CI: -8.837 to -3.985; <em>P</em> &lt; 0.01) and Brief Fatigue Inventory scores (MD = -1.687; 95 %CI: -2.350 to -1.023; <em>P</em> &lt; 0.01). From NMA results, Jianpi Yiqi Huatan Formula + RT was the best for improving efficacy rate, Kangai Injection + RT excelled in reducing PFS scores and enhancing QLQ-C30 scores, and Aidi Injection + RT was the most effective in elevating KPS scores. No serious adverse events were reported. However, poor RCTs quality and uncertain bias risk were common in this study.</div></div><div><h3>Conclusion</h3><div>Our study showed that TCM was effective and safe for CRF in lung cancer. However, given the poor quality and uncertain risk of bias, the results should be interpreted cautiously. More standardized RCTs are needed in the future.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100683"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145050734","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Discovery of antioxidant peptides from Humulus scandens by multi-step virtual screening, molecular docking, ligand efficiency analysis, and molecular dynamics simulation","authors":"Shi Qi Xu ,&nbsp;Wenchao Gong ,&nbsp;Wenjie Qin ,&nbsp;Dong-Hwa Chung ,&nbsp;De Xin Dang","doi":"10.1016/j.prmcm.2025.100715","DOIUrl":"10.1016/j.prmcm.2025.100715","url":null,"abstract":"<div><h3>Background</h3><div>Reactive oxygen species (ROS) are generated under both physiological and pathological conditions, including strenuous exercise, inflammation, and unhealthy dietary intake. Excessive ROS accumulation induces oxidative stress, which damages cellular components and contributes to the onset and progression of chronic diseases. Efficient elimination of ROS is therefore essential for maintaining redox homeostasis and promoting health. Antioxidant peptides derived from herbal medicines have recently gained increasing attention due to their natural origin, safety, and multifunctional biological activities. Compared with synthetic antioxidants, which may raise safety concerns with long-term use, these bioactive peptides represent a promising alternative.</div></div><div><h3>Purpose</h3><div>This study aimed to investigate Humulus scandens (HS), a traditional herbal medicine with reported antioxidant capacity, as a potential source of novel antioxidant peptides.</div></div><div><h3>Methods</h3><div>A systematic in silico workflow was applied, integrating virtual screening, molecular docking, ligand efficiency analysis, and molecular dynamics simulations. Keap1, a critical regulator of oxidative stress signaling, was selected as the molecular target.</div></div><div><h3>Results</h3><div>Seven candidate peptides were identified based on predicted non-toxicity, bioactivity, and favorable intestinal absorption. Among these, the tripeptide PGW demonstrated the greatest potential. Molecular docking revealed that PGW interacts with Keap1 through 10 hydrogen bonds, 1 hydrophobic interaction, and 22 van der Waals forces. Subsequent molecular dynamics simulations confirmed the stability of the PGW-Keap1 complex and supported its strong binding affinity.</div></div><div><h3>Conclusions</h3><div>The tripeptide PGW, derived from HS protein, exhibits promising antioxidant potential through direct interaction with Keap1. These findings highlight PGW as a candidate for development into functional food ingredients or nutraceuticals aimed at preventing oxidative stress-related disorders.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100715"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528540","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Geographical origin identification, heavy metal contamination evaluation, and risk assessment of oysters from different regions based on multi-element fingerprinting","authors":"Yuan-sheng Guo ,&nbsp;Tian-tian Zuo ,&nbsp;Hong-yu Jin ,&nbsp;Jing Liu ,&nbsp;Xian-long Cheng ,&nbsp;Feng Wei","doi":"10.1016/j.prmcm.2025.100700","DOIUrl":"10.1016/j.prmcm.2025.100700","url":null,"abstract":"<div><h3>Background</h3><div>Oysters are one of the most important marine biological resources worldwide, with high nutritional and medicinal value. Enhancing the traceability of oyster products can provide crucial information to improve their quality and safety. <em><strong>Methods:</strong></em> This study focuses on oysters from three different production areas. Multi-element analysis was conducted to establish a multi-element fingerprint for oysters from various regions by ICP-MS. Combined with chemometric methods such as Hierarchical Cluster Analysis (HCA) and Principal Component Analysis (PCA), the study aims to trace the geographic origin of the oysters. Additionally, single-factor pollution index and the Nemerow Index were employed to assess the heavy metal contamination levels in oysters from different regions. Based on these findings, a risk assessment was conducted according to industry guidelines to evaluate the potential health risks to humans from consuming oysters from different production areas.</div></div><div><h3>Results</h3><div>Chemometric analysis revealed that oyster samples from different production areas clustered into distinct groups with significant difference. The elements Na, Rb, Sn, and Fe were identified as the primary factors responsible for these differences. Additionally, a comprehensive evaluation of heavy metal contamination in oysters from various regions was conducted using both the single-factor pollution index method and the Nemerow composite index method, providing insight into their contamination levels. Based on these results, a risk assessment strategy was applied to evaluate the edible safety of the oysters. The findings indicated that, except for some oyster samples from the northeastern region, which posed certain health risks, oysters from other areas were found to have acceptable health risk levels.</div></div><div><h3>Conclusion</h3><div>This approach effectively distinguishes the geographical origin of oysters and scientifically assess both heavy metal contamination and health risks, offering valuable strategies for the safety risk assessment of oysters and other traditional Chinese medicines.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100700"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Retraction notice to “Inhibition of oxido-inflammatory and apoptotic pathway is involved in the protective effect of Ginkgo biloba supplement in cyclosporine-A induced vascular dysfunction in Wistar rat” [Pharmacological Research – Modern Chinese Medicine 7 (2023) 100252]","authors":"Jerome Ndudi Asiwe ,&nbsp;Simon Irikefe Ovuakporaye ,&nbsp;Benneth Ben-Azu ,&nbsp;Jamil Usman Dauda ,&nbsp;Vincent-Junior Onoriode Igben ,&nbsp;Endurance Efe Ahama ,&nbsp;Ehizokhale Santos Ehebha ,&nbsp;Vincent Ugochukwu Igbokwe","doi":"10.1016/j.prmcm.2025.100704","DOIUrl":"10.1016/j.prmcm.2025.100704","url":null,"abstract":"","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100704"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145736395","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional wisdom to modern science: Hesperetin and naringenin as emerging traditional Chinese medicine-based treatments for Alzheimer’s disease","authors":"Dhani Ramachandran ,&nbsp;Win Win May ,&nbsp;Abu Bakar Abdul Majeed ,&nbsp;Sakina Ruhi ,&nbsp;Hanish Singh Jayasingh Chellammal","doi":"10.1016/j.prmcm.2025.100718","DOIUrl":"10.1016/j.prmcm.2025.100718","url":null,"abstract":"<div><h3>Background</h3><div>Hesperetin and naringenin are the two flavonoids that are widely applied in Traditional Chinese Medicine (TCM) and mostly found in citrus fruits. Both flavonoids have shown considerable neuroprotective potential. These substances originate from glycosidic precursors, hesperidin and naringin, which are chiefly found in medicinal plants like <em>Zanthoxylum avicennae</em> and <em>Citrus reticulata</em>. In TCM, these botanicals are historically utilized for their analgesic, anti-inflammatory, and digestive properties, but their potential in influencing neurodegenerative processes is receiving growing scrutiny.</div></div><div><h3>Objective</h3><div>The aim of this review is to cumulate the neuroprotective properties by systematically retrieving the peer-reviewed preclinical and clinical trial research and studies performed in hesperetin and naringenin on multiple mechanisms connected with AD.</div></div><div><h3>Methods</h3><div>A complete systematic review has been employed by applying MeSH search terms through the application of keywords such as “Alzheimer’s Disease”, “Neuroprotection”, “amyloid”, molecular mechanistic pathways of AD which are discussed in this review and “Clinical trials” for the polyphenols naringenin and hesperetin. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) analysis method was used for screening of the research studies conducted on naringenin and hesperetin.</div></div><div><h3>Results and discussion</h3><div>The review retrieved 319 articles in respect to the hesperetin and naringenin on neurodegenerative diseases related to AD. Further scrutinised to 87 with terms of decrease of amyloid-beta aggregation, prevention of tau hyperphosphorylation, mitigation of oxidative stress, and suppression of neuroinflammation. Furthermore, they affect essential molecular cascades, including the PI3K/AKT, NRF2/ARE, and NF-κB signalling pathways, which are intricate for neuronal survival and cognition. It was also found that their ability to cross the blood-brain barrier further amplifies their pharmacological significance in central nervous system illnesses.</div></div><div><h3>Conclusion</h3><div>Hesperetin and naringenin, as natural multifunctional agents derived from traditional practices, present intriguing opportunities for integrative treatment approaches to AD, connecting the insights of TCM with contemporary neuropharmacology. Further, our review reveals several mechanisms; hesperetin and naringenin are yet to be evaluated in aspects of the hypothalamic-pituitary-adrenal axis (HPA) associated with the stress pathway of neurodegeneration, and exploring the HPA renders additional mechanistic neuroprotective recognition.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100718"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579081","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ameliorative effects of traditional Chinese medicine formula NRICM101 on periodontal inflammation: In vitro and in vivo","authors":"Fang-Wei Lin ,&nbsp;Yann-Jen Chen ,&nbsp;Hui-Rong Cheng ,&nbsp;Chi-Tsung Wu ,&nbsp;Hsien-Chung Chiu","doi":"10.1016/j.prmcm.2025.100708","DOIUrl":"10.1016/j.prmcm.2025.100708","url":null,"abstract":"<div><h3>Introduction</h3><div>Taiwan Chingguan Yihau (NRICM101) is a novel anti-inflammatory traditional Chinese medicine formula developed in 2020 for COVID-19 pandemic. This study aimed to evaluate the effect of NRICM101 on periodontal inflammation, using human gingival fibroblasts (HGFs) exposed to <em>Porphyromonas gingivalis</em> lipopolysaccharide (Pg LPS) and rat models of ligature-induced periodontitis.</div></div><div><h3>Methods</h3><div><em>In vitro</em>, HGFs were stimulated with Pg LPS and NRICM101. Cell viability and the expression of pro-inflammatory cytokines, including interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and IL-1β were measured using MTS assay and reverse transcription quantitative polymerase chain reaction (RT-qPCR). <em>In vivo</em>, Sprague-Dawley rats were divided into control, ligature placement, and NRICM101 treatment groups. Ligature placement was performed at day one and oral administration of NRICM101 (50 or 100 mg/kg body weight/day) or saline began one day prior to ligation and the following days. On day 8, the rats were sacrificed, periodontal tissue specimens were analyzed using microcomputed tomography (Micro-CT) imaging, RT-qPCR, and immunohistochemical (IHC) staining to evaluate the effects of the treatments.</div></div><div><h3>Results</h3><div>NRICM101 reduced HGFs viability above 1.0 mg/mL, while Pg LPS caused similar effects at concentrations above 1.0 μg/mL. Co-treatment with Pg LPS (0.5–1.0 μg /mL) and NRICM101 (0.1–0.5 mg/mL) showed no cytotoxicity. <em>In vivo</em>, NRICM101 attenuated alveolar bone loss and significantly decreased IL-6, TNF-α, and partially IL-1β expression, as confirmed by micro-CT, RT-qPCR, and IHC analyses.</div></div><div><h3>Discussion</h3><div>This study demonstrates that NRICM101 exerts protective anti-inflammatory effects in both cellular and animal models of periodontitis. It suppressed pro-inflammatory cytokine expression in HGFs and mitigated alveolar bone loss in ligature-induced periodontitis rats. The effects on IL-6 and TNF-α were pronounced, while the partial reduction of IL-1β may reflect additional regulatory mechanisms such as inflammasome activation, which warrants further investigation. These findings indicate that NRICM101 reduces inflammation without cytotoxicity and supports its potential application in managing chronic periodontal inflammation.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100708"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145363239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of a combination of Nigella sativa, Momordica charantia, and Anethum graveolens in metabolic syndrome management: An in vivo study","authors":"Rajashekar S. Chavan ,&nbsp;Nayeem A. Khatib ,&nbsp;Vishal S. Patil ,&nbsp;Jagadeesh Dodakallanavar","doi":"10.1016/j.prmcm.2025.100716","DOIUrl":"10.1016/j.prmcm.2025.100716","url":null,"abstract":"<div><h3>Background</h3><div>Metabolic syndrome (MetS) is a multifactorial disorder characterized by abdominal obesity, insulin resistance (IR), hypertension, dyslipidemia, and an increased risk of type 2 diabetes mellitus (T2DM) and cardiovascular diseases (CVDs). Conventional pharmacological interventions primarily manage symptoms but are associated with adverse effects. Bioactive compounds from medicinal plants offer promising multi-targeted therapeutic benefits. This study evaluates the efficacy of a polyherbal formulation containing extracts of <em>Nigella sativa</em> (NS, seed), <em>Momordica charantia</em> (MC, fruit), and <em>Anethum graveolens</em> (AG, fruit) in mitigating MetS-induced complications in an olanzapine (Zyprexa)-induced MetS rat model.</div></div><div><h3>Methods</h3><div>Animals were divided into five groups: normal control (saline), disease control (olanzapine (Zyprexa) 2 mg/kg, i.p., twice daily), and three treatment groups receiving olanzapine (Zyprexa) with formulations containing combination of NS, MC, and AG at 200 mg/kg (100:50:50), 400 mg/kg (200:100:100), and 800 mg/kg (400:200:200) orally. The study assessed metabolic parameters, including blood glucose levels, body weight, food and water intake, lipid profile, and Hemoglobin A1c/ glycated hemoglobin (HbA1c) levels. Cardiac activity function was evaluated using electrocardiography (ECG). Antioxidant status was assessed by estimating superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) levels in tissue homogenates of the heart, liver, and pancreas. Histopathological examinations of these organs were also performed.</div></div><div><h3>Results</h3><div>Polyherbal formulation 800 mg/kg (400:200:200 ratio) significantly reduced blood glucose levels, improved lipid profiles, and mitigated weight gain induced by olanzapine (Zyprexa). ECG analysis demonstrated cardioprotective effects. Antioxidant enzyme activity, including SOD, CAT, and GSH levels, was notably improved in tissue homogenates. Histopathological evaluation further confirmed the protective effects on the liver, heart, and pancreas.</div></div><div><h3>Conclusion</h3><div>The findings suggest that the polyherbal formulation exerts protective effects against MetS by ameliorating blood glucose levels, improving lipid profile, enhancing antioxidant status, and preserving tissue architecture, thereby highlighting its potential as a natural therapeutic alternative for the management of metabolic syndrome.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100716"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145528411","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ailanthus altissima (Mill.) Swingle notably decreases the cholesterol induced hyperlipidemia in albino rats","authors":"Weekar Younus Raja ,&nbsp;Insha Mushtaq ,&nbsp;Nisar Ahmad Dar ,&nbsp;Mohmmad Akbar Dar ,&nbsp;Ishtiyaq Ahmad Chashoo ,&nbsp;Zulfiqar Ali Bhat","doi":"10.1016/j.prmcm.2025.100698","DOIUrl":"10.1016/j.prmcm.2025.100698","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Ailanthus altissima</em>, also known as Chun Pi, is native to central and northern China, and several other parts of Central Asia. <em>Ailanthus altissima</em> is used traditionally in the treatment of various diseases, such as obesity, dysentery, asthma, spasms, gastric and intestinal upsets, hemorrhoids and cardiac problems.</div></div><div><h3>Methods</h3><div>The present study aimed to evaluate the effects of A. altissima root bark extracton serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein cholesterol (LDL-c), high-density lipoprotein cholesterol (HDL-c), very low-density lipoprotein cholesterol (VLDL-c), SGOT, SGPT, ALP, total protein, total bilirubin, atherogenic index(AI), cardiac risk index I, atherogenic coefficient, and cardiac risk index II (LDL/HDL ratio). Hyperlipidemia was induced in albino rats via cholesterol administration, and the rats were treated orally with methanol and aqueous extracts at doses of 200 and 400 mg/kg b.w. for 30 days.</div></div><div><h3>Results</h3><div>Treatment with <em>Ailanthus altissima</em> extract significantly reduced serum TG, total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), and low-density lipoprotein cholesterol (VLDL-C) levels and increased high-density lipoprotein cholesterol (HDL-C) levels. The observed effects on the lipid profiles were comparable to those of atorvastatin, a standard antihyperlipidemic drug. Additionally, the plant extracts notably decreased the liver enzyme levels (SGOT, SGPT, and ALP), indicating a protective effect on liver function.</div></div><div><h3>Discussion</h3><div>Our findings demonstrated that the root bark aqueous extract of Ailanthus altissima effectively reduced hyperlipidemia and improved lipid profiles. The extract significantly improved various atherogenic indices and cardiac risk factors, highlighting its potential as a promising therapeutic agent for preventing atherosclerosis and related cardiovascular diseases. The observed benefits underscore its ability to lower cholesterol levels and reduce cardiovascular risk, suggesting that Ailanthus altissima could be a valuable natural alternative for the management of hyperlipidemia and cardiovascular health.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100698"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145268681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of Traditional Chinese medicinal plants in the management of fibromyalgia: A review","authors":"Kaniga Pandi,&nbsp;Binoy Varghese Cheriyan,&nbsp;Kunal R. Kataria","doi":"10.1016/j.prmcm.2025.100707","DOIUrl":"10.1016/j.prmcm.2025.100707","url":null,"abstract":"<div><h3>Introduction</h3><div>Fibromyalgia is a chronic, multifactorial disorder characterized by widespread musculoskeletal pain, fatigue, sleep disturbances, and cognitive impairments, substantially reducing quality of life. Conventional pharmacological therapies, including analgesics, antidepressants, and anticonvulsants, provide only partial relief and are often associated with adverse effects. This highlights the need for safer and more effective alternatives. Traditional Chinese Medicine (TCM) has a long history of managing chronic pain conditions through medicinal plants, which may offer therapeutic benefits in fibromyalgia.</div></div><div><h3>Methods</h3><div>A systematic literature search was performed across PubMed, Scopus, Web of Science, and CNKI databases using predetermined inclusion and exclusion criteria. The focus was on studies reporting the phytochemical composition, pharmacological actions, and clinical outcomes of TCM medicinal plants relevant to fibromyalgia.</div></div><div><h3>Results</h3><div>Several plants with potential therapeutic effects were identified, including <em>Panax ginseng</em> (Ren Shen), <em>Corydalis yanhusuo</em> (Yan Hu Suo), <em>Salvia miltiorrhiza</em> (Dan Shen), and <em>Astragalus membranaceus</em> (Huang Qi). Their bioactive compounds, ginsenosides, tetrahydropalmatine, salvianolic acids, ferulic acid, and astragalosides, exert multimodal actions. These include modulation of neurotransmitter pathways, reduction of pro-inflammatory cytokines, antioxidative activity, and improvement of mitochondrial function. Preclinical studies demonstrate analgesic, anti-fatigue, and neuroprotective effects, while limited clinical evidence suggests improvements in pain, sleep, and overall well-being.</div></div><div><h3>Discussion</h3><div>Although preliminary findings are promising, current evidence is limited by small sample sizes, heterogeneous herbal formulations, and lack of standardized dosing regimens. Well-designed, large-scale randomized controlled trials are essential to validate efficacy, establish safety profiles, and support the integration of TCM herbal therapies into evidence-based fibromyalgia management.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"17 ","pages":"Article 100707"},"PeriodicalIF":0.0,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145417335","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}