Therapeutic role of isoflavones from traditional medicine in the management of polycystic ovary syndrome

Ashwini Armarkar , Prafulla Sabale , Satyendra Prasad , Vidya Sabale , Lata Potey , Dipti Masram
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Abstract

Introduction

Polycystic ovary syndrome (PCOS) is a significant public health problem and one of the most common gynaecological and endocrine disorder.This condition affects an estimated 8–13 % of women of reproductive age worldwide. PCOS manifests as a group of symptoms, including oligomenorrhea, obesity, infertility, increased risk of diabetes, acne, and hirsutism. The etiology of PCOS involves a complex interplay of factors, including genetic predisposition, neuroendocrine dysregulation, contemporary lifestyle practices, and obesity. Numerous traditional chinese formulations have demonstrated success in mitigating PCOS symptoms and addressing its underlying causes.

Methodology

Online databases such as Google Scholar, PubMed, and ScienceDirect Library were employed to find literatures on “Polycystic ovary syndrome,” “Phytoestrogens,” “Pharmacokinetics of Isoflavones” Role of isoflavones in PCOS. considering articles published in the last 20 years to capture recent research.This review summarizes the scientific findings on traditional herbs rich in isoflavones and their bioactive components of the phytoestrogen class for the management of PCOS.

Result

Isoflavones, a subset of polyphenolic compounds, represent a prominent class of phytoestrogens. These secondary plant metabolites, which predominantly occur in the Fabaceae family, exhibit structural similarities to 17β-estradiol, and typically exist in conjugated forms. The estrogenic properties of isoflavone phytoconstituents, such as genistein, biochanin A, daidzein, puerarin, and formononetin, confer substantial therapeutic potential for PCOS management.

Conclusion

Despite their therapeutic potential, there is a paucity of data regarding the safety profile, clinical efficacy, and optimal treatment duration of isoflavones. Further investigations across various domains of isoflavone research are imperative to enhance the understanding of this complex field of study.

Abstract Image

中药异黄酮在多囊卵巢综合征治疗中的作用
多囊卵巢综合征(PCOS)是一个重大的公共卫生问题,也是最常见的妇科和内分泌疾病之一。这种情况影响全世界约8 - 13%的育龄妇女。多囊卵巢综合征表现为一系列症状,包括月经减少、肥胖、不育、糖尿病风险增加、痤疮和多毛症。多囊卵巢综合征的病因涉及多种因素的复杂相互作用,包括遗传易感性、神经内分泌失调、当代生活方式和肥胖。许多传统的中国配方已经证明在减轻多囊卵巢综合征症状和解决其根本原因方面取得了成功。方法利用谷歌Scholar、PubMed、ScienceDirect Library等在线数据库查找“多囊卵巢综合征”、“植物雌激素”、“异黄酮的药代动力学”等异黄酮在PCOS中的作用的文献。考虑过去20年发表的文章来捕捉最新的研究。本文综述了富含异黄酮及其雌激素类生物活性成分的传统中药治疗多囊卵巢综合征的研究进展。结果黄酮类化合物是一类重要的植物雌激素,是多酚类化合物的一个子集。这些次生植物代谢物主要存在于豆科植物中,其结构与17β-雌二醇相似,通常以共轭形式存在。异黄酮植物成分的雌激素特性,如染料木素、生物茶素A、大豆苷元、葛根素和刺芒柄花素,赋予了PCOS管理的巨大治疗潜力。结论尽管异黄酮具有治疗潜力,但关于其安全性、临床疗效和最佳治疗时间的数据缺乏。异黄酮研究的各个领域的进一步调查是必要的,以加强对这一复杂研究领域的理解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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