Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"Study on mechanism of Miao medicine Xinnao Liantong capsule in treatment of myocardial ischemia diseases based on network pharmacology and molecular docking","authors":"Yuan Yao ,&nbsp;Huan Zhang ,&nbsp;Na Zhan ,&nbsp;Yong Deng ,&nbsp;Jianyong Zhang","doi":"10.1016/j.prmcm.2025.100629","DOIUrl":"10.1016/j.prmcm.2025.100629","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the mechanism of Miao Medicine Xinnao Liantong Capsule (XNLTC) in treating myocardial ischemia (MI) using network pharmacology and molecular docking techniques.</div></div><div><h3>Methods</h3><div>Active components of XNLTC were screened from the TCMSP, TCMBANK, and HERB databases, followed by target prediction using SwissTargetPrediction. MI-related targets were obtained from the GEO, GeneCards, and OMIM databases. A \"herb-active components-intersection targets\" network was constructed, and protein-protein interaction analyses were performed using Cytoscape and STRING. Functional enrichment analyses were performed using DAVID, and molecular docking was employed to validate core component-target interactions.</div></div><div><h3>Results</h3><div>Network analysis revealed 282 bioactive components in XNLTC interacting with 1,131 targets and 3,232 MI-related targets. Seven core components (quercetin, eleutheroside B, rutin, puerarin, polydatin, salvianolic acid B, and scutellarin) and six key targets (AKT1, SRC, STAT3, MAPK1, and MAPK3) were identified. Pathway analysis demonstrated significant modulation of lipid metabolism and atherosclerosis, apoptosis, as well as fluid shear stress and atherosclerosis signaling pathways. All binding energies were less than −5.0 kcal/mol, confirming stable molecular interactions.</div></div><div><h3>Conclusions</h3><div>XNLTC exerts therapeutic effects against MI by modulating key pathways, including lipid metabolism and atherosclerosis, apoptosis, and fluid shear stress and atherosclerosis. These findings validate its clinical potential and provide mechanistic insights into the applications of traditional medicine.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100629"},"PeriodicalIF":0.0,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144154886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"“Cassia auriculata-derived silver nanoparticles as a novel male contraceptive agent”","authors":"Prity Yadav ,&nbsp;Neha Bharti ,&nbsp;Phulwanti Kumari Sharma ,&nbsp;Pratap Chand Mali","doi":"10.1016/j.prmcm.2025.100626","DOIUrl":"10.1016/j.prmcm.2025.100626","url":null,"abstract":"<div><h3>Introduction</h3><div>The development of male contraception remains a crucial area of research in reproductive health. Nanotechnology offers innovative solutions, with plant-derived nanoparticles emerging as potential antifertility agents. This study explores the antifertility effects of <em>Cassia auriculata</em>-derived silver nanoparticles (AgNPs) as a novel approach to male contraception. <em>Cassia auriculata</em>, a medicinal plant with known therapeutic properties, plants of the genus Cassia are used mainly in traditional Chinese medicine (TCM) to control type 2 diabetes, skin and wound healing, as a mild laxative, and for urinary tract health, with active constituents including 1-Tetradecanol, Anthraquinone, Emodin, Quercetin-3-glucoside, β-sitosterol, Rutin, β-sitosterol-β-D-glucoside, was utilized for the green synthesis of AgNPs, ensuring eco-friendliness and biocompatibility.</div></div><div><h3>Methods</h3><div>The synthesized nanoparticles were characterized using UV-Vis spectroscopy, XRD (X-Ray diffraction), FTIR (Fourier Transform Infra-Red), DLS (Dynamic Light Scattering), Zeta Potential, and SEM (Scanning Electron Microscopy) to confirm their physicochemical properties.</div></div><div><h3>Results</h3><div>In vivo studies on male albino rats revealed significant reductions in sperm density and motility, alongside alterations in testicular and epididymal histology, indicating impaired spermatogenesis. Hormonal analysis showed a decline in testosterone levels, further supporting the antifertility potential of these nanoparticles. Importantly, toxicity assessments confirmed minimal systemic side effects, highlighting their safety profile.</div></div><div><h3>Discussion</h3><div>The findings suggest that <em>Cassia auriculata</em>-derived AgNPs could be a promising non-hormonal male contraceptive with reversible effects. This research underscores the potential of nanotechnology in reproductive health and paves the way for further clinical investigations into plant-based nanoparticle contraceptives.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100626"},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dysbioactive, hepato-haematological and biochemical systemic health implications of Zingiber officinale Roscoe: an experimental model","authors":"Patience O Adomi ,&nbsp;Bright E Igere ,&nbsp;Anthony Jude Anozie ,&nbsp;Ubreye B Owhe-Ureghe","doi":"10.1016/j.prmcm.2025.100627","DOIUrl":"10.1016/j.prmcm.2025.100627","url":null,"abstract":"<div><h3>Introduction</h3><div>Given the presumed diverse bioactivity of <em>Zingiber officinale roscoe</em> (ginger) in culinary, folkloric and traditional Chinese and alternative medicine, it has emerged as a focus of research with a view to understand its impact on hepatic-haematological indices, biochemical markers, tissue histology, and gastrointestinal microbiota. Jiang as ginger is called in Traditional Chinese Medicine (TCM) has been applied in cold related infection cases, osteo/rheumatoid arthritis, bowel inflammation cases etc. Suffice it to say that the gastrointestinal tract, being an important site of food receipt, nutrient absorption and immune modulation, it is influenced significantly by dietary and phytochemical interventions, including ginger. However, the underlying implications by which ginger affects systemic health and its specific impact on haematological and biochemical markers remain unattended. This study explores the dysbioactive/multifaceted implications of ginger on gut miicrobiota and its impact on hepato-hematological and systemic health indices using experimental models. It also evaluate/establish the preventive/therapeutic, alternative medicinal and TCM potentials of ginger.</div></div><div><h3>Methods</h3><div>Basic and standard microbiological, histological and biochemical approach were employed while sampling forty male albino rats of approximately 12–18 weeks old (130–150 g) and treated with varying concentration of ginger crude water extract.</div></div><div><h3>Results</h3><div>results revealed distinct variations in bacterial profiles across different weeks in relation to the applied treatments compared to the control group, which indicates dysbiotic activity of ginger. A similar and significant (<em>p</em> &gt; 0.01) dysbiotic effect was observed for gut heterotrophic coliform count, while revealing impact on hepatocyte and haematological indices following the dosage applied.</div></div><div><h3>Discussion</h3><div>An investigation into the optimal dosage and concentration of ginger to achieve effective health benefits is suggestive in enhancing hepto-hematological, gastrointestinal health and overall well-being especially as applied in modern Chinese medicine (MCM) and TCM for the production of some seasoning agents as well as white ginger sushi, ginger soy sauce and the white pickled ginger slice etc., as food additive to improve wellbeing.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100627"},"PeriodicalIF":0.0,"publicationDate":"2025-05-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144124999","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Research status and prospects of Chinese medicine herb Asparagus cochinchinensis","authors":"Miao Liu ,&nbsp;Liu Tang ,&nbsp;Yongquan Li ,&nbsp;Gonggu Lv ,&nbsp;Ming-sheng Zhang","doi":"10.1016/j.prmcm.2025.100625","DOIUrl":"10.1016/j.prmcm.2025.100625","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Asparagus cochinchinensis</em> (Lour.) Merr (<em>A. cochinchinensis</em>) well known as traditional Chinese medicinal herb, listed as a homology of medicine and food. It has long been employed in medical applications, including anti-cancer, antibacterial, anti-inflammatory, antioxidant, and anti-aging treatments. In recent years, its edible, feeding, and ornamental values have also attracted widespread attention.</div></div><div><h3>Methods</h3><div>A comprehensive review of scientific databases, including Scopus, PubMed, Web of Science, and the National Knowledge Infrastructure of China, was conducted to gather comprehensive insights. The keywords used included \"<em>A. cochinchinensis</em>\", \"resource distribution\" \"pharmacological properties\" and \"associated quality control\". Studies from both outdoor analysis and in vivo experiments were considered, ensuring a well-rounded evaluation of the herb’s effects.</div></div><div><h3>Results</h3><div>Currently, <em>A. cochinchinensi</em>s is widely distributed in China, mainly in <em>Guizhou, Sichuan</em>, and <em>Yunnan</em> as the main production areas, and usually relies on tissue culture technology for manufacturing purposes. The primary pharmacological characteristics are thought to stem from its saponin and polysaccharide elements present in vivo. Research indicates that <em>A. cochinchinensis</em> exhibits properties of antibacterial agents, reducing inflammation, combating aging, and curbing tumours. Moreover, its alleviation of depression and Alzheimer's disease has ignited curiosity about its possible therapeutic uses. Moreover, its proven nutritional worth has boosted public research and development in the by-products.</div></div><div><h3>Discussion</h3><div>The pharmacological impacts of various <em>A. cochinchinensis</em> origins and sources might differ, and the regulatory routes of saponins and polysaccharides, mainly responsible for these effects, remain ambiguous. Concurrently, additional clinical information is required to substantiate the pharmacological impact of <em>A. cochinchinensis</em>. Consequently, additional studies are imperative regarding the application and safety aspects of herbal medicine.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100625"},"PeriodicalIF":0.0,"publicationDate":"2025-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144108005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional Chinese medicine in prostate cancer: Exploring pharmacological effects and mechanisms as a novel therapeutic dimension","authors":"Sobhanjan Bhunia ,&nbsp;Sonia Mallick ,&nbsp;Asif Iqbal Mondal ,&nbsp;Arkaprava Saha ,&nbsp;Sumana Chatterjee ,&nbsp;Tamalika Chakraborty","doi":"10.1016/j.prmcm.2025.100623","DOIUrl":"10.1016/j.prmcm.2025.100623","url":null,"abstract":"<div><h3>Introduction</h3><div>Prostate cancer (PCa) is a leading malignancy among men worldwide, characterized by the uncontrolled proliferation of malignant prostate cells. Despite advancements in surgical and radiation therapies, androgen deprivation therapy (ADT) remains the primary treatment for advanced PCa. However, treatment resistance often leads to castration-resistant prostate cancer (CRPC), which poses significant therapeutic challenges. Traditional Chinese Medicine (TCM) has been explored as a potential adjunct therapy for PCa due to its multi-targeted approach, enhancing immune response and mitigating drug resistance. This study investigates the molecular mechanisms of PCa progression and the therapeutic potential of TCM formulations in PCa management.</div></div><div><h3>Methodology</h3><div>A thorough literature search was performed across multiple databases, including PubMed, Scopus, Google Scholar, and Web of Science. Articles published between 2000 and 2024 were screened based on relevant keywords such as \"Traditional Chinese Medicine,\" \"formulations,\" “Extracts”, \"bioactive compounds,\" \"prostate cancer,\" \"molecular mechanisms,\" and \"metastasis.\" From an initial collection of 220 articles, 164 were deemed relevant for inclusion. Chemical structures and mechanistic pathways were illustrated using ChemDraw software, adhering to established guidelines and utilizing structural data from the PubChem database.</div></div><div><h3>Results</h3><div>PCa progression is primarily driven by androgen receptor (AR) signaling, with aberrations in oncogenic pathways such as PI3K/Akt/mTOR contributing to tumor proliferation. TCM-derived compounds demonstrated significant anti-PCa activity by inducing apoptosis, proliferation, and cell cycle arrest. Moreover, TCM formulations exhibited the potential to suppress PCa progression and overcome drug resistance in CRPC models. Clinical studies indicated improved survival outcomes and reduced adverse effects when TCM was combined with standard therapies.</div></div><div><h3>Discussion</h3><div>The findings suggest that TCM offers a promising complementary approach to PCa management by targeting multiple oncogenic pathways and reducing treatment-related side effects. However, further clinical trials are necessary to validate these therapeutic effects and establish standardized formulations for integration into modern oncology. Future research should focus on the molecular interactions of TCM with conventional therapies to optimize patient outcomes in PCa treatment.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100623"},"PeriodicalIF":0.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143931380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of potential neuropharmacological activity and attenuating effect in chronic constriction induced neuropathic pain using Calotropis procera (Aiton) Dryand flower ethanol extract","authors":"Ashutosh Kumar ,&nbsp;Brijesh Kumar ,&nbsp;Rajesh Kumar ,&nbsp;Vinod Tiwari ,&nbsp;Pratistha Singh ,&nbsp;Ajay Kumar ,&nbsp;Manish Singh ,&nbsp;Chandra Shekhar Azad ,&nbsp;Ankit Uniyal","doi":"10.1016/j.prmcm.2025.100624","DOIUrl":"10.1016/j.prmcm.2025.100624","url":null,"abstract":"<div><h3>Background</h3><div><em>Calotropis procera</em>, also known as \"毒竹 du zhu\" in Chainese, is used in several remedies to treat a variety of ailments, including inflammatory diseases, skin concerns, pain disorders, and respiratory issues. It has been observed that the various parts of the plant have been traditionally used for as anti-inflammatory and neuroprotective actions. The flower of this herb has not been investigated for these pharmacological properties.</div></div><div><h3>Purpose</h3><div>The aim of this research is to investigate the neuropharmacological profile and ameliorative potential of ethanolic extract of <em>C. procera</em> flower (EECP) in chronic constriction injury (CCI) induced neuropathic pain in rats.</div></div><div><h3>Methods</h3><div>GCMS analysis was performed to identify the active phytocmpounds of the plant. Neuropharmacological profile has been investigated by maximal electroshock seizure and pentylenetetrazole for antiepileptic, elevated maze plus and open field test for anxiety, tail suspension and forced swim test for depressant activity, and acetylcholinesterase and Morris water maze test for cognition. Anti-neuropathic pain was assessed via heat hyperalgesia and mechanical allodynia tests in rats after inducing CCI. Pro-inflammatory mediators (TNF-α, IL-1β, and IL-6) were determined by ELISA kits. SOD and nitrile level were measured for antioxidant activity. Sciatic nerve’s histopathological changes for nerve deformity were evaluated by H &amp;E staining.</div></div><div><h3>Results</h3><div>GCMS analysis revealed the presence of phytocompounds Lupeool, acetate, n-hexadecanoic acid, γ-sitosterol, hexadecanoic acid methyl ester, Octadecenoic acid (Z)-, methyl ester, β-Amyrin, phytol and other compounds. In neuropharmacological profile, EECP had a significant anticonvulsant effect, a decrease in locomotor activity, indicating a sedative effect but showed no anxiolytic effect. The immobility time decreased significantly in both the forced swim test and tail suspension test. The activity of acetylcholinesterase in the brain was decreased and Morris water test results revealed a shorter escape latency and greater time spent in the target quadrant. In anti-neuropathic pain assessment, the EECP reduced CCI-induced hyperalgesia and mechanical allodynia. TNF-α, IL-1β, and IL-6 levels were reduced while SOD levels increased and nitrite levels decreased in the sciatic nerve. Histological analysis revealed sciatic nerve deformity was reduced.</div></div><div><h3>Conclusion</h3><div>It is concluded that extract showed a potent antiepileptic, antidepressant, cognition enhancer and protective against nerve deformity and neuropathic pain. Phytocompounds identified via GCMS having neuroprotective, antioxidant, and anti-inflammatory properties, which may be correlated with the neuropharmacological and analgesic activities of the extract.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100624"},"PeriodicalIF":0.0,"publicationDate":"2025-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144098387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pharmacodynamic study of Gubi granules in the treatment of osteoarthritis","authors":"Yingxia Bao ,&nbsp;Liyu Hao ,&nbsp;Yiqiu Liao ,&nbsp;Jianhui Sun ,&nbsp;Yiman Chen ,&nbsp;Jianliang Li ,&nbsp;Hongmei Li ,&nbsp;Lingli Wang ,&nbsp;Jiansong Wang","doi":"10.1016/j.prmcm.2025.100621","DOIUrl":"10.1016/j.prmcm.2025.100621","url":null,"abstract":"<div><h3>Background</h3><div>Osteoarthritis (OA) is an aging-associated degenerative disease, primarily characterized by joint stiffness pain and progressive destruction of articular cartilage. Gubi granules is a classic hospital-prepared formulation specifically for the treatment of OA.</div></div><div><h3>Methods</h3><div>Papain-induced and modified Hulth models were established in rats to investigate the protective effects of Gubi granules. Pathological alterations in rat cartilage tissues were observed through hematoxylin and eosin (H&amp;E) staining, and then quantitatively scored using the Mankin score. Commercially available kits were employed to measure the levels of PGE2 and iNOS in rat serum. The anti-inflammatory effects of Gubi Granules were investigated by croton-oil-induced ear swelling model in mice, carrageenan-induced paw swelling and cotton-pellet-induced granuloma models in rats. Moreover, the analgesic effect was evaluated by the acetic acid-induced writhing test in mice.</div></div><div><h3>Results</h3><div>The results showed that Gubi granules significantly alleviated the pathological changes of osteoarticular tissues, and remarkably decreased the Mankin score of joints and the extent of joint swelling (<em>P</em> &lt; 0.01). Additionally, Gubi Granules led to a significant reduction in the serum levels of PGE2 and iNOS (<em>P</em> &lt; 0.01). Moreover, Gubi granules significantly supressed ear swelling in mice (<em>P</em> &lt; 0.05), paw swelling and cotton-pellet-induced granuloma in rats (<em>P</em> &lt; 0.01), as well as significantly inhibited the writhing response in mice (<em>P</em> &lt; 0.01).</div></div><div><h3>Conclusion</h3><div>These findings indicate that Gubi granules exhibit notable anti-inflammatory and analgesic properties, and demonstrate a significant therapeutic efficacy against osteoarthritis, Overall, these results provide an experimental basis to support the clinical application of Gubi Granules in the management of osteoarthritis.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100621"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143927933","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential of traditional Chinese medicine loaded nanocarriers in wound management: Current status and their future perspective","authors":"Jitendra Gupta ,&nbsp;Devesh Kumar ,&nbsp;Reena Gupta ,&nbsp;Diksha Diwakar ,&nbsp;Kumari Shanno ,&nbsp;Arpan Kumar Tripathi ,&nbsp;Akshay Kumar ,&nbsp;Mohit Kumar","doi":"10.1016/j.prmcm.2025.100622","DOIUrl":"10.1016/j.prmcm.2025.100622","url":null,"abstract":"<div><h3>Introduction</h3><div>Wound healing is the main physiological process that repairs tissue injury and maintains the body’s protective barrier. Traditional Chinese medicine (TCM) has long been known for its herbal remedies promote wound healing. Nanocarriers, which include liposomes, nanoparticles, and hydrogel, enhance the stability, bioavailability, and targeted delivery of TCM’s bioactive component. The integration of nanotechnology and TCM represents and an emerging frontier for advanced wound care.</div></div><div><h3>Methods</h3><div>Data was gathered from PubMed, ScienceDirect, and Google Scholar databases covering the period from 1965 to 2024 to ensure comprehensive inclusion of relevant literature. The search utilized keywords such as Traditional Chinese Medicine, Wound Healing, Herbal TCM, and Nanocarrier Systems. Studies that investigated the pharmacological effects of TCM in combination with nanocarriers were selected for analysis. Experimental wound healing models, in vitro assays, and in vivo animal studies were included to assess the efficacy of nanocarrier systems in enhancing the therapeutic potential of TCM as a nanotheranostic approach.</div></div><div><h3>Results</h3><div>The results showed that TCM compounds in nanocarriers like liposomes, nanoparticles, and hydrogel had a big impact on wound healing. Different TCMs, such as <em>Acorus calamus, Artemisia annua, Angelica dahurica,</em> etc., showed enhanced bioavailability and sustained release when incorporated into nanocarrier systems. In animal tests, they increased collagen production, lowered inflammation, and accelerated epithelialisation in preclinical models.</div></div><div><h3>Conclusion</h3><div>The integration of TCM with nanocarrier technology presents a promising approach to pursuing wound healing therapies. Nanocarriers increase the bioavailability and medical effect of TCM compounds, providing more effective and targeted treatment for wound care. The combination of ancient knowledge of TCM with modern nanotechnology can bring revolution in the future to heal wounds and provide innovative solutions for fast and more effective recovery.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100622"},"PeriodicalIF":0.0,"publicationDate":"2025-04-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143903724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Caloric restriction combined with Linggui Zhugan Decoction improves palmitic acid-induced insulin resistance","authors":"Li Zhang ,&nbsp;Ting-ying Zhang ,&nbsp;Zi-heng Ye,&nbsp;Jia-hao Feng,&nbsp;Jin Zhao,&nbsp;Peng Huang,&nbsp;Jian Qin,&nbsp;Jia-pan Sun,&nbsp;Tao-li Liu","doi":"10.1016/j.prmcm.2025.100620","DOIUrl":"10.1016/j.prmcm.2025.100620","url":null,"abstract":"<div><h3>Introduction</h3><div>To explore the effects and probable mechanisms of caloric restriction (CR) combined with Linggui Zhugan pharmaceutic serum on insulin resistance (IR).</div></div><div><h3>Methods</h3><div>Sprague–Dawley rats were treated with Linggui Zhugan decoction (LGZGD) or equivalent amount of saline as blank control by gavage for one week, after which blood was collected from the abdominal aorta to prepare LGZGD pharmaceutic serum or control serum. HepG2 cells were incubated with normal control medium or 30 % CR culture medium supplemented with LGZGD pharmaceutic serum or control serum for 24 h and then exposed to 250 μM palmitic acid (PA) for another 24 h. Changes in cellular glucose uptake were detected to evaluate the improvements in insulin resistance, and changes in the expression changes of AKT, p-AKT, and AS160 were detected via western blotting and qPCR.</div></div><div><h3>Results</h3><div>Both simple caloric restriction (30 %) and LGZGD pharmaceutic serum treatment significantly improved the decrease in cellular glucose uptake and the downregulation of AKT/p-AKT/AS160 signaling induced by PA, and the combined intervention group had a significantly greater effect than the single intervention groups.</div></div><div><h3>Discussion</h3><div>Linggui Zhugan decoction can enhance the effects of CR on improving insulin resistance in HepG2 cells. The potential mechanism may be related to the modulation of AKT/p-AKT/AS160 signaling, which needs to be verified further with knock-down experiment and in vivo study.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100620"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143891246","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Arjunolic acid from Rhodomyrtus tomentosa suppresses growth of non-small cell lung cancer via inducing autophagy and apoptosis","authors":"Ziying Huang ,&nbsp;Chang Liu ,&nbsp;Chenchen Zhang ,&nbsp;Huanling Wu ,&nbsp;Siqin Li ,&nbsp;Caihong Wei ,&nbsp;Yi Zhang ,&nbsp;Zechi Xing ,&nbsp;Minhui Lin ,&nbsp;Guang Yang ,&nbsp;Jiang Ma ,&nbsp;Bin Jiang ,&nbsp;Min Hong ,&nbsp;Xin He ,&nbsp;Ji Yang","doi":"10.1016/j.prmcm.2025.100616","DOIUrl":"10.1016/j.prmcm.2025.100616","url":null,"abstract":"<div><h3>Introduction</h3><div>non‑small cell lung cancer (NSCLC), a kind of lung cancer (LC), led to a large number of cancer-related deaths. <em>Rhodomyrtus tomentosa</em> (<em>R. tomentosa</em>), a traditional Chinese medicine, has proven to possess potential inhibitory activities in NSCLC, but the active material basis and possible mechanism remain unclear. This study aims to clarify the active compound from <em>R. tomentosa</em> and the mechanism of that inhibits NSCLC.</div></div><div><h3>Methods</h3><div>To clarify the anti-NSCLC material basis of <em>R. tomentosa</em>, a bioassay-guided fractionation of the ethanolic extract of <em>R. tomentosa</em> was performed. The anticancer effects were evaluated through <em>in-vitro</em> and <em>in-vivo</em> models, and the cell viability and the levels of PARP cleavage were measured through MTT assays, flow cytometry, and western blot assays. The core target was recognized by Network pharmacology analysis and further confirmed by western blot and molecular docking experiments.</div></div><div><h3>Results</h3><div>As a result, an active compound, Arjunolic acid (AA), was isolated from the anti-NSCLC fraction which repressed the proliferation and migration of A549, PC9, and H1975 cell lines in a dose- and time-dependent manner. AA exhibited the most potent inhibition of cell viability in PC9 cells for 24 and 48 h (IC₅₀ = 199.0 ± 7.47, 120.8 ± 6.72 <em>μ</em>M) and in A549 cells for 72 h (IC₅₀ = 65.06 ± 18.33 <em>μ</em>M). Moreover, AA induced apoptosis and autophagy in three NSCLC cell lines and also effectively suppressed tumor growth in the Lewis lung cancer (LLC) tumor-bearing C57BL/6 mice. AA-induced apoptosis is associated with increased levels of PARP cleavage. Additionally, AA could induce autophagy through the downregulation of p62 and upregulation of LC3 Ⅱ/I ratio. Network pharmacology analysis indicated that IL-6 might be a core target of AA in the treatment of NSCLC.</div></div><div><h3>Discussion</h3><div>These data reveal that AA exerts anti-NSCLC effects by inducing apoptosis and autophagy which may be associated with the expression of IL-6 protein.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100616"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143935813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}