Pharmacological Research - Modern Chinese Medicine最新文献

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Imperatorin suppresses NSCLC via interaction with PI3K/AKT pathway and PD-L1: Computational and experimental evidence Imperatorin通过与PI3K/AKT通路和PD-L1相互作用抑制NSCLC:计算和实验证据
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-07-13 DOI: 10.1016/j.prmcm.2025.100661
Yifei Xu , Shunjiang Jia , Zhijian Liang , Shuxian Gong , Zhongyuan Long , Yuwei Wang , Huanling Lai
{"title":"Imperatorin suppresses NSCLC via interaction with PI3K/AKT pathway and PD-L1: Computational and experimental evidence","authors":"Yifei Xu ,&nbsp;Shunjiang Jia ,&nbsp;Zhijian Liang ,&nbsp;Shuxian Gong ,&nbsp;Zhongyuan Long ,&nbsp;Yuwei Wang ,&nbsp;Huanling Lai","doi":"10.1016/j.prmcm.2025.100661","DOIUrl":"10.1016/j.prmcm.2025.100661","url":null,"abstract":"<div><h3>Background</h3><div>Non-small cell lung cancer (NSCLC) remains a leading cause of cancer-related mortality globally, underscoring the critical need for novel therapeutic agents. Imperatorin (IMP), a natural furanocoumarin compound derived from various traditional Chinese medicine plants including <em>Angelica dahurica</em> (Baizhi) and <em>Peucedanum praeruptorum</em> (Qianhu), has shown promising anti-cancer properties. This study aimed to elucidate the therapeutic mechanisms of IMP against NSCLC.</div></div><div><h3>Methods</h3><div>The anti-NSCLC activity of IMP was evaluated through in vitro cytotoxicity and colony formation assays. Network pharmacology analysis was employed to identify potential targets of IMP in NSCLC. Molecular docking simulations predicted binding affinities and interactions between IMP and its targets. The antitumor efficacy and molecular mechanisms of IMP were further validated using in vivo xenograft models.</div></div><div><h3>Results</h3><div>IMP exhibited time-dependent growth inhibition in NSCLC cell lines H1975 and A549, with 48-hour IC50 values of 5.28 ± 0.50 µM and 14.17 ± 3.02 µM, respectively, while showing minimal cytotoxicity toward normal lung CCD19-Lu cells. In vivo, IMP significantly suppressed tumor growth in a nude mouse xenograft model. Network pharmacology identified 379 common targets between IMP and NSCLC, predominantly associated with the PI3K-AKT signaling pathway, with the PD-L1 signaling pathway emerging as an additional relevant target. Molecular docking analysis revealed strong interactions between IMP and key PI3K/AKT pathway proteins. Subsequent in vivo experiments confirmed that IMP treatment inhibited PI3K and AKT activation while downregulating PD-L1 expression.</div></div><div><h3>Conclusions</h3><div>Our findings demonstrate that IMP exerts multi-target effects against NSCLC, particularly through modulation of the PI3K/AKT and PD-L1 pathways, suggesting its potential as both a therapeutic agent and an immunomodulator in NSCLC treatment.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100661"},"PeriodicalIF":0.0,"publicationDate":"2025-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Phytochemical constituents, therapeutic potential and toxicity of Gardenia jasminoides Ellis: An in-depth review 栀子的植物化学成分、治疗潜力和毒性研究进展
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-07-12 DOI: 10.1016/j.prmcm.2025.100662
Mahima Tiwari, Suruchi, Ajay Kumar Gupta, Dipti Pal, Sanmati Kumar Jain
{"title":"Phytochemical constituents, therapeutic potential and toxicity of Gardenia jasminoides Ellis: An in-depth review","authors":"Mahima Tiwari,&nbsp;Suruchi,&nbsp;Ajay Kumar Gupta,&nbsp;Dipti Pal,&nbsp;Sanmati Kumar Jain","doi":"10.1016/j.prmcm.2025.100662","DOIUrl":"10.1016/j.prmcm.2025.100662","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Gardenia jasminoides Ellis</em> (GJE), also known as \"Cape Jasmine,\" is an East Asian blooming species indigenous to East Asia. This plant has extensive utility in the history of Traditional Chinese Medicine and is acknowledged for its ability to combat inflammation, safeguard liver health and possess antioxidant capabilities.</div></div><div><h3>Objective</h3><div>This review seeks to examine the ethnopharmacological importance of GJE<em>,</em> emphasizing its historical applications, bioactive constituents, and possible therapeutic benefits as well as toxicity.</div></div><div><h3>Methods</h3><div>An investigation into the phytoconstituents, extraction techniques, and pharmacological effects of the GJE was conducted using a variety of academic databases and search engines. These included Google Scholar, PubMed, China National Knowledge Infrastructure (CNKI), Flora of China, Wanfang Database, Plant of the World Online, ChemSpider, European and Mediterranean Plant Protection Organization (EPPO) Global Database, Springer Link, and Science Direct.</div></div><div><h3>Outcomes</h3><div>An examination uncovers a variety of bioactive phytoconstituents, such as flavonoids, iridoid glycosides, gardenia’s yellow pigment, monoterpenoids, sesquiterpenoids, triterpenoids, organic acids and their derivatives, along with other compounds. These components are crucial to the wide-ranging pharmacological applications, which encompass antioxidant, anti-inflammatory, anti-diabetic, cardiovascular disorders, neurodisorders, anti-tumor, treatment of liver injury, anti-hepatic injury, gastrocellular activity, improvement of gut microbiota, atopic dermatitis, anti-viral, improvement of the quality of sleep, protection from blue light and ultraviolet rays, vitiligo, inhibition of retinal damage, antibacterial activity, anti-senescence activity, anti-thrombosis, osteoporosis protection and postmenopausal syndrome treatment.</div></div><div><h3>Conclusion</h3><div>GJE is an important medicinal plant recognized for its diverse pharmacological advantages, which are underpinned by its extensive phytochemical composition. Despite its considerable therapeutic promise, it is essential to take its toxicity into account, especially at elevated doses. Additional research is necessary to evaluate its safety profile and enhance its medicinal uses.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100662"},"PeriodicalIF":0.0,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144687239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Interactions between traditional chinese medicine and gut microbiota in chronic diseases 慢性疾病中中药与肠道菌群的相互作用
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-07-10 DOI: 10.1016/j.prmcm.2025.100659
Lei Chen , Meijun Liu , Xiaoli Chen , Aiping Lyu , Kenneth Cheung , Yongai Xiong
{"title":"Interactions between traditional chinese medicine and gut microbiota in chronic diseases","authors":"Lei Chen ,&nbsp;Meijun Liu ,&nbsp;Xiaoli Chen ,&nbsp;Aiping Lyu ,&nbsp;Kenneth Cheung ,&nbsp;Yongai Xiong","doi":"10.1016/j.prmcm.2025.100659","DOIUrl":"10.1016/j.prmcm.2025.100659","url":null,"abstract":"<div><h3>Introduction</h3><div>The gut microbiota (GM) is a vast and dynamic community of microorganisms residing in the mammalian gastrointestinal tract. It plays a vital role in the absorption, digestion, metabolism, and distribution of food and drugs. Dysbiosis of GM is increasingly recognized as a key contributor to the development of intestinal disorders such as irritable bowel syndrome (IBS), Crohn's disease, and colorectal cancer. Moreover, GM communicates with distant organs through various axes, including the brain-gut, liver-gut, and lung-gut axes, thereby participating in the pathogenesis of systemic diseases such as Alzheimer's disease, non-alcoholic fatty liver disease, liver cancer, and lung cancer.</div></div><div><h3>Methods</h3><div>This review systematically examines the recent literature on the bidirectional interaction between traditional Chinese medicine (TCM) and GM, focusing on preclinical and clinical studies. Emphasis is placed on the mechanisms through which GM influences the pharmacokinetics and pharmacodynamics of TCM, including microbial enzymatic activities such as hydrolysis, redox reactions, and deacetylation.</div></div><div><h3>Results</h3><div>GM can significantly impact both the efficacy and toxicity of TCM by transforming its active ingredients. Conversely, TCM and its active compounds also modulate the composition and function of GM, contributing to the prevention and treatment of chronic diseases. Key chronic conditions covered in this review include gastrointestinal, neurological, hepatic, and pulmonary diseases.</div></div><div><h3>Discussion</h3><div>The interaction between TCM and GM represents a promising avenue for personalized medicine and targeted interventions for GM-related diseases. Understanding these complex interactions provides a theoretical basis for developing novel TCM-based strategies to prevent and treat chronic conditions through modulation of the gut microbiota.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100659"},"PeriodicalIF":0.0,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144657014","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcriptomics revealed potential anti-inflammatory mechanisms of ethanol extracts of propolis and tree gum in lipoteichoic acid and interferon-γ-stimulated RAW264.7 macrophages 转录组学揭示了蜂胶和树胶乙醇提取物对脂壁酸和干扰素γ刺激的RAW264.7巨噬细胞的潜在抗炎机制
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-07-07 DOI: 10.1016/j.prmcm.2025.100660
Zongze Li, Zhengxin Liu, Yuyang Guo, Yujing Tang, Ting Li, Shuangshuang Gao, Hongzhuan Xuan
{"title":"Transcriptomics revealed potential anti-inflammatory mechanisms of ethanol extracts of propolis and tree gum in lipoteichoic acid and interferon-γ-stimulated RAW264.7 macrophages","authors":"Zongze Li,&nbsp;Zhengxin Liu,&nbsp;Yuyang Guo,&nbsp;Yujing Tang,&nbsp;Ting Li,&nbsp;Shuangshuang Gao,&nbsp;Hongzhuan Xuan","doi":"10.1016/j.prmcm.2025.100660","DOIUrl":"10.1016/j.prmcm.2025.100660","url":null,"abstract":"<div><h3>Introduction</h3><div>Poplar propolis, a traditional Chinese medicine abundant in phenolic acids and flavonoid compounds, demonstrates remarkable anti-inflammatory activity. It is currently widely applied in the pharmaceutical and health product industries for the prevention and adjuvant treatment of various diseases. However, due to the limited availability of natural propolis, its primary plant source—tree gum—is often used as an adulterant, posing significant challenges for the authenticity and quality control of propolis products. Therefore, this study aimed to compare the anti-inflammatory effects of ethanol extracts of poplar propolis (EEP) and tree gum (EEG) on RAW264.7 macrophages co-stimulated with lipoteichoic acid (LTA) and interferon-gamma (IFN-γ) using in vitro cellular assays. Furthermore, transcriptomic analysis was employed to elucidate the molecular mechanisms underlying the anti-inflammatory activities of EEP and EEG.</div></div><div><h3>Methods</h3><div>Widely targeted metabolomics was used to analyze metabolites of EEP and EEG. A RAW264.7 macrophage inflammation model was established using LTA and IFN-γ co-stimulation, and optimal concentrations of EEP and EEG were determined. ELISA and RT-qPCR were used to assess inflammatory cytokines, inflammation-related genes, and antioxidant genes. Reactive oxygen species (ROS) levels were measured with a DCFH-DA probe. Transcriptomics, RT-qPCR, and Western blotting were employed to evaluate signaling pathway-related markers.</div></div><div><h3>Results</h3><div>The results showed that 1635 metabolites were identified in EEP and 1545 metabolites were identified in EEG by widely targeted metabolomics. Compared to EEG, EEP more effectively inhibited the release of inflammatory factors, regulated inflammatory gene expression, reduced ROS production, and elevated antioxidant gene expression. RT-qPCR and Western blot analyses revealed that EEP and EEG suppressed the inflammatory response in LTA/IFN-γ-stimulated RAW264.7 macrophages by downregulating cell adhesion molecule expression, inhibiting the MAPK signaling pathway, and activating the autophagy pathway.</div></div><div><h3>Discussion</h3><div>Propolis exhibited superior efficacy over tree gum in suppressing inflammatory responses and enhancing antioxidant defenses. These findings offer a theoretical foundation for the quality control and further development of propolis as a potential anti-inflammatory agent.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100660"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604675","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Buyang Huanwu Decoction attenuates silicosis progression via NF-κB/IL-17 signaling axis modulation: a network pharmacology and experimental validation study 补阳还五汤通过NF-κB/IL-17信号轴调节减缓矽肺进展:网络药理学和实验验证研究
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-07-06 DOI: 10.1016/j.prmcm.2025.100657
Hejuntao Chen, Ruiyang Wang, Xu Chen, Wenli Liu, Huihui Fang, Yaya Xie, Fan Yin, Xiaojuan Wang
{"title":"Buyang Huanwu Decoction attenuates silicosis progression via NF-κB/IL-17 signaling axis modulation: a network pharmacology and experimental validation study","authors":"Hejuntao Chen,&nbsp;Ruiyang Wang,&nbsp;Xu Chen,&nbsp;Wenli Liu,&nbsp;Huihui Fang,&nbsp;Yaya Xie,&nbsp;Fan Yin,&nbsp;Xiaojuan Wang","doi":"10.1016/j.prmcm.2025.100657","DOIUrl":"10.1016/j.prmcm.2025.100657","url":null,"abstract":"<div><h3>Background</h3><div>Silicosis is a prevalent, irreversible occupational pulmonary fibrotic disease caused by crystalline silica dust inhalation. Buyang Huanwu Decoction (BYHWD), a classical Chinese herbal formula with anti-inflammatory and circulation-enhancing properties, shows potential in inhibiting pulmonary fibrosis. This study investigated its preventive mechanism against silicosis based on TCM’s \"preventive treatment\" principle.</div></div><div><h3>Methods</h3><div>Network pharmacology identified BYHWD-silicosis overlapping targets using TCMSP and disease databases. Protein-protein interaction (PPI) networks were constructed (STRING/Cytoscape), followed by GO/KEGG pathway enrichment (Metscape). Mechanistic validation employed in vivo silicosis models: Mice received preventive BYHWD administration prior to silica exposure. Lung fibrosis was assessed via H&amp;E staining and immunohistochemistry (IHC). Key targets in the NF-κB/IL-17 pathway were quantified by Western blotting and qPCR. Liver/kidney toxicity was evaluated through serum biochemical analysis and histopathology.</div></div><div><h3>Results</h3><div>Network pharmacology analysis revealed that the therapeutic effects of BYHWD on silicosis are potentially mediated through regulation of the NF-κB/IL-17 signaling pathway. In vivo mechanistic studies confirmed that preventive administration of BYHWD prior to silica exposure significantly attenuated pulmonary fibrosis progression. This protective effect was associated with suppression of the NF-κB/IL-17 signaling axis. Additionally, BYHWD treatment did not induce significant impairment in liver or kidney function in mice.</div></div><div><h3>Discussion</h3><div>These findings support the therapeutic potential of Buyang Huanwu Decoction in intervening in silicosis progression. The study provides novel insights into the molecular mechanism underlying BYHWD's efficacy, specifically highlighting its role in modulating the NF-κB/IL-17 pathway. The lack of significant hepatorenal toxicity further suggests a favorable safety profile for BYHWD in this context. This study proposes a novel therapeutic strategy for targeting silicosis progression.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100657"},"PeriodicalIF":0.0,"publicationDate":"2025-07-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Inhibition of enzymatic browning and antioxidant activities of Marrubium vulgare L extracts: A promising natural solution 抑制酶褐变和抗氧化活性:一种有前途的天然解决方案
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-07-05 DOI: 10.1016/j.prmcm.2025.100658
Karim Tighilet , Ahmed Adjebli , Abdelaziz Messis
{"title":"Inhibition of enzymatic browning and antioxidant activities of Marrubium vulgare L extracts: A promising natural solution","authors":"Karim Tighilet ,&nbsp;Ahmed Adjebli ,&nbsp;Abdelaziz Messis","doi":"10.1016/j.prmcm.2025.100658","DOIUrl":"10.1016/j.prmcm.2025.100658","url":null,"abstract":"<div><h3>Introduction</h3><div><em>Marrubium vulgare</em> L. (苦薄荷或) has been traditionally utilized in Traditional Chinese Medicine (TCM) for its cooling, detoxifying, and phlegm-resolving properties. Despite its historical use, limited pharmacological evidence exists regarding its phytochemical profile and antioxidant mechanisms in relation to enzymatic browning.</div></div><div><h3>Methods</h3><div>Methanolic and aqueous extracts from the leaves and stems of <em>M. vulgare</em> were assessed for total phenolic, flavonoid, and condensed tannin content. Antioxidant activities were evaluated using DPPH, ABTS, and β-carotene bleaching assays. Inhibitory effects against peroxidase (POD) and polyphenol oxidase (PPO) were examined through enzyme kinetics.</div></div><div><h3>Results</h3><div>Methanolic leaf extracts exhibited the highest phenolic (35.36 ± 0.42 mg GAE/g DW) and flavonoid content (20.56 ± 0.35 mg QE/g DW), correlating with superior antioxidant activity (IC<sub>50</sub> = 20.83 ± 0.62 μg/mL in DPPH assay). Condensed tannins were most abundant in aqueous stem extracts. Enzyme inhibition studies revealed mixed-type inhibition for POD and competitive inhibition for PPO, with methanolic leaf extracts being the most potent (51.40 % PPO inhibition; Km = 0.810 mM, Vmax = 0.595 ΔA/min).</div></div><div><h3>Discussion</h3><div>These results highlight the pharmacological relevance of <em>M. vulgare</em>, particularly its leaf extracts, as natural antioxidants and anti-browning agents. The variation in inhibition mechanisms suggests differential interaction of bioactive compounds with enzyme targets, aligning with their traditional TCM usage for internal heat and inflammation.</div></div><div><h3>Conclusion</h3><div><em>M. vulgare</em> exhibits significant antioxidant and enzymatic inhibitory properties, supporting its development as a multifunctional ingredient in food, cosmetic, and medicinal applications.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100658"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144604673","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The study of the cold and heat properties of Dianthus superbus and Odontites vulgaris based on multi-sample metabolomics and gut microbiota analysis: Exploring material and energy metabolism mechanisms 基于多样本代谢组学和肠道菌群分析的石竹和齿齿石冷热特性研究:探索物质和能量代谢机制
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-07-03 DOI: 10.1016/j.prmcm.2025.100654
Yafeng Zhuang , Xiangxi Meng , Jiayin Chang , Xiaolei Jiang , Hong Chang , Minhui Li
{"title":"The study of the cold and heat properties of Dianthus superbus and Odontites vulgaris based on multi-sample metabolomics and gut microbiota analysis: Exploring material and energy metabolism mechanisms","authors":"Yafeng Zhuang ,&nbsp;Xiangxi Meng ,&nbsp;Jiayin Chang ,&nbsp;Xiaolei Jiang ,&nbsp;Hong Chang ,&nbsp;Minhui Li","doi":"10.1016/j.prmcm.2025.100654","DOIUrl":"10.1016/j.prmcm.2025.100654","url":null,"abstract":"<div><h3>Objective</h3><div><em>Dianthus superbus</em> (DS)and <em>Odontites vulgaris</em> (OV) are crucial components of the Mongolian medicine \"Bashaga\", each possessing unique efficacy. However, their cold and heat natures remain to be experimentally verified. The aim of this study is to validate the medicinal natures of DS and OV and to elucidate the underlying mechanisms from the perspectives of substance and energy metabolism as well as gut microbiota.</div></div><div><h3>Methods</h3><div>In this study, <em>Anemarrhena asphodeloides</em> (AA, a cold-natured traditional Chinese medicine) and <em>Cinnamomum cassia</em> (CC,a heat-natured traditional Chinese medicine) were used as references to explore the impacts of DS and OV on the material and energy metabolism, multi-sample metabolomics, and gut microbiota in normal rats. This method aims to evaluate the medicinal properties of these plants and clarify their underlying mechanisms.</div></div><div><h3>Results</h3><div>In terms of material and energy metabolism, the content of Sodium-Potassium Adenosine Triphosphatase (Na⁺/ K⁺ -ATP) in DS and OV was lower than the normal level (<em>p &lt; 0.05</em>). In DS, Pyruvate Kinase (PK) was significantly decreased (<em>p</em> &lt; 0.01), Adenylate Kinase (ADK) was decreased (<em>p &lt; 0.001</em>), and Citrate Synthase (CS) was increased (<em>p &lt; 0.05</em>). In OV, ADK was decreased (<em>p &lt; 0.01</em>) and Glycogen Synthase Kinase 3 Alpha (GSK - 3α) was increased (<em>p &lt; 0.05</em>). AA showed a similar situation. In terms of metabolomics, the metabolic profiles and clustering heatmaps of DS, OV, and AA were similar. AA affected the tryptophan-related metabolic pathways, while CC affected the glutamate-related metabolic pathways. Regarding the gut microbiota, DS, OV, and AA all increased the diversity and richness of the microbiota. At the phylum and genus levels, the composition of the microbiota was similar, and the abundances of various microbiota changed differently.</div></div><div><h3>Conclusion</h3><div>DS and OV exhibit cold-natured characteristics, as evidenced by their impacts on metabolism and gut microbiota. These findings provide preliminary insights into the potential mechanisms underlying their medicinal properties.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100654"},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587702","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neuroprotective effects of p-coumaric acid against chemical-induced dementia in mice 对香豆酸对小鼠化学诱导痴呆的神经保护作用
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-07-03 DOI: 10.1016/j.prmcm.2025.100656
Harsimran Singh , Navneet Khurana , Pallavi Anand Bafna , Rupa Mazumder , Neha Sharma
{"title":"Neuroprotective effects of p-coumaric acid against chemical-induced dementia in mice","authors":"Harsimran Singh ,&nbsp;Navneet Khurana ,&nbsp;Pallavi Anand Bafna ,&nbsp;Rupa Mazumder ,&nbsp;Neha Sharma","doi":"10.1016/j.prmcm.2025.100656","DOIUrl":"10.1016/j.prmcm.2025.100656","url":null,"abstract":"<div><h3>Introduction</h3><div>Dementia, a progressive and debilitating neurological disorder, affects millions of people worldwide and remains a significant global health challenge. Traditional plant-based medicines, especially those used in Chinese herbal practices, have shown promise in managing memory-related disorders. One such bioactive compound is <em>p</em>-coumaric acid, a naturally occurring phytoconstituent present in several traditional Chinese medicinal plants, including <em>Hedyotis diffusa, Fagopyrum cymosum</em>, and <em>Viola yedoensis</em>. Known for its antioxidant, anti-inflammatory, and neuroprotective properties, <em>p</em>-coumaric acid was investigated in this study for its potential to mitigate chemically induced dementia in mice.</div></div><div><h3>Methods</h3><div>A total of 54 Swiss albino mice weighing 25-35 g (either sex) were used in the present study, which were distributed into 9 groups Two interoceptive dementia models were utilized. In model 1, mice received aluminum chloride (5 mg/kg, orally) and D-galactose (60 mg/kg, intraperitoneally) for 90 days. In model 2, dementia was induced by administering L-methionine (750 mg/kg at 09:00 and 15 mg/kg, i.p. at 15:00) over seven days. Treatment groups received either <em>p</em>-coumaric acid at low (100 mg/kg, orally) or high (400 mg/kg, orally) doses, or the standard drug donepezil HCl (2 mg/kg, i.p.). Behavioral performance was assessed using the Morris water maze and elevated plus maze. At the end of the treatment period, brains were harvested for biochemical analyses including AChE, TBARS, SOD, catalase, GSH, nitrite, and TNF-α levels.</div></div><div><h3>Results</h3><div><em>p</em>-Coumaric acid significantly improved spatial memory and cognitive function, as evidenced by reduced escape and transfer latency times and increased time spent in the target quadrant. It also restored antioxidant enzyme levels and reduced markers of oxidative stress and inflammation in both models.</div></div><div><h3>Conclusion</h3><div>Overall, the findings suggest that <em>p</em>-coumaric acid enhances cholinergic transmission, mitigates oxidative damage, and reduces neuroinflammation, indicating its potential as a therapeutic agent for dementia management.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100656"},"PeriodicalIF":0.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662618","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The role of Lactobacillus in diseases and its intervention by Chinese herbs 乳酸菌在疾病中的作用及中药的干预作用
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-07-02 DOI: 10.1016/j.prmcm.2025.100655
Hui Lai , Dongmei Yan , Jiarong Zhang , Bin Li , Fei Li
{"title":"The role of Lactobacillus in diseases and its intervention by Chinese herbs","authors":"Hui Lai ,&nbsp;Dongmei Yan ,&nbsp;Jiarong Zhang ,&nbsp;Bin Li ,&nbsp;Fei Li","doi":"10.1016/j.prmcm.2025.100655","DOIUrl":"10.1016/j.prmcm.2025.100655","url":null,"abstract":"<div><h3>Introduction</h3><div>Lactobacilli are a group of Gram-positive bacteria belonging to the family Lactobacillaceae within the phylum Firmicutes. They colonize the intestinal tract and play a significant role in human health and disease treatment, serving irreplaceable functions in numerous disease domains. These include intestinal diseases (such as inflammatory bowel disease, diarrhea, colorectal cancer, etc.), viral respiratory infections, type 2 diabetes-related periodontitis, and urinary system diseases (prevention of vaginal diseases and urinary tract infections).</div></div><div><h3>Aim of the Review</h3><div>This review focuses on the mechanisms of action of lactobacilli in diseases, the regulatory effects of diet and Chinese herbal medicine, and summarizes the impacts of Chinese herbal medicine on lactobacilli. It aims to explain the relationships among diseases, lactobacilli, and Chinese herbal medicine, providing theoretical support for promoting the research and development of related products.</div></div><div><h3>Methods</h3><div>Literature related to lactobacilli was collected by searching the academic databases PubMed and CNKI using keywords such as characteristics of lactobacilli, biological functions, metabolic pathways, roles in diseases, mechanisms of action, and regulation by Chinese herbal medicine.</div></div><div><h3>Results</h3><div>Based on the collected literature, this review summarizes the characteristics, biological functions, metabolic pathways, roles in diseases, and mechanisms of action of lactobacilli, as well as the regulatory effects of diet, single Chinese herbal medicines, and Chinese herbal compound formulas on the abundance of lactobacilli.</div></div><div><h3>Discussion</h3><div>Dietary and Chinese herbal medicine interventions significantly influence the growth and reproduction of intestinal lactobacilli. A high-protein diet and specific carbohydrates can regulate lactobacilli levels, but their specific mechanisms of action remain unclear. The molecular-level interactions with host cells and the signaling pathways under different disease states are not yet fully understood. Future research could deeply analyze the molecular-level interactions between lactobacilli and host cells, clarify the key signaling pathways activated or inhibited under different disease conditions, and provide a theoretical basis for precision treatment.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100655"},"PeriodicalIF":0.0,"publicationDate":"2025-07-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144587898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green synthesis of europium oxide nanoparticles via Vitex trifolia: Biomedical applications in infection control and cancer therapy 利用三叶荆绿色合成氧化铕纳米颗粒:在感染控制和癌症治疗中的生物医学应用
Pharmacological Research - Modern Chinese Medicine Pub Date : 2025-06-28 DOI: 10.1016/j.prmcm.2025.100652
Tiyah Jimmy Chheda , Rajakumar Govindasamy , Suganya Panneer Selvam , Dhivya Viswanathan
{"title":"Green synthesis of europium oxide nanoparticles via Vitex trifolia: Biomedical applications in infection control and cancer therapy","authors":"Tiyah Jimmy Chheda ,&nbsp;Rajakumar Govindasamy ,&nbsp;Suganya Panneer Selvam ,&nbsp;Dhivya Viswanathan","doi":"10.1016/j.prmcm.2025.100652","DOIUrl":"10.1016/j.prmcm.2025.100652","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to synthesize europium oxide nanoparticles (Eu₂O₃ NPs) using <em>Vitex trifolia</em> leaf extract through a green synthesis approach and evaluate their antibacterial and anticancer properties for potential biomedical applications.</div></div><div><h3>Methodology</h3><div>Eu₂O₃ NPs were synthesized from <em>Vitex trifolia</em> leaf extract using 0.4 M europium nitrate, 1 M sodium borohydride, and ammonia, confirmed by a color change. The nanoparticles were characterized using FTIR, XRD, and SEM, while their antibacterial activity was assessed against <em>Pseudomonas aeruginosa, Streptococcus mutans, Enterococcus sp</em>., and <em>Klebsiella sp</em>. via the agar well diffusion method. Cytotoxicity assays on A549 cancer cells evaluated anticancer potential, with the IC50 value determined through dose-response analysis.</div></div><div><h3>Results</h3><div>XRD and SEM analysis confirmed that the synthesized Eu₂O₃ NPs had an average size of 82 nm, while FTIR spectra revealed the presence of phytochemicals involved in nanoparticle stabilization. Antibacterial assays using the agar well diffusion method demonstrated significant activity, with <em>Enterococcus sp</em>. showing the highest sensitivity, exhibiting inhibition zones of 19 ± 0.49 mm, 15 ± 0.35 mm, 17 ± 0.45 mm, and 18 ± 0.53 mm at varying concentrations. Cytotoxicity assays on A549 cancer cells showed a dose-dependent reduction in cell viability. The IC50 value for anticancer activity was approximately 100 µg/mL, confirming effective cancer cell inhibition.</div></div><div><h3>Conclusion</h3><div>The biogenic synthesis of europium oxide (Eu₂O₃) nanoparticles utilizing extract from <em>Vitex trifolia</em> presents an environmentally friendly and sustainable method for nanoparticle production. These nanoparticles exhibited significant antibacterial properties and notable anticancer potential, positioning them as promising candidates for biomedical applications, particularly in the realms of antimicrobial therapy and cancer treatment.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"16 ","pages":"Article 100652"},"PeriodicalIF":0.0,"publicationDate":"2025-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144557255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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