Pharmacological Research - Modern Chinese Medicine最新文献

{"title":"Traditional Chinese medicine Yiqi Huoxue Huatan recipe inhibits atherosclerosis by regulating intestinal flora and its associated metabolites","authors":"Hongtao Huang ,&nbsp;Wenqing Lv ,&nbsp;Hanjun Zhao ,&nbsp;Feiyue Xu ,&nbsp;Yu Huang","doi":"10.1016/j.prmcm.2025.100593","DOIUrl":"10.1016/j.prmcm.2025.100593","url":null,"abstract":"<div><h3>Background</h3><div>Yiqi Huoxue Huatan recipe (YHHR) has been shown to possess anti-atherosclerotic effects, as detailed in various studies and clinical observations. However, the potential mechanism underlying atherosclerosis remains unclear. This study aimed to verify the effects of YHHR on gut microbiota composition and plasma metabolite levels in atherosclerotic mice and its mechanism of action.</div></div><div><h3>Materials and Methods</h3><div>SPF apoE-/- mice were fed high-fat chow for 12 weeks to build an atherosclerosis model, Additionally, blank control group mice were fed normal chow, Mice were randomly assigned to the model group, low, medium and high dose YHHR group, antibiotic group and antibiotic + medium dose YHHR group. After three courses of drug administration, aortic plaques were observed by hematoxylin and eosin (HE) and Oil Red O staining, and mouse feces and serum were collected. The feces and serum of mice were analyzed using 16S rRNA sequencing, microbiological analysis, and targeted metabolomics. For cellular experiments, by constructing a foam cell model and applyingglycoursodeoxycholic acid(GUDCA)and Compound C interventions, WB was used to detect macrophage AMPK signaling pathway-related protein (AMPK) and efferocytosis-associated protein (ProS).</div></div><div><h3>Results</h3><div>YHHR was able to attenuate atherosclerotic plaque area, up-regulate the levels of gut bacteria <em>Akkermansia muciniphila (A. muciniphila)</em> and gut bacteria-associated metabolite bile acids GUDCA, and promote macrophage efferocytosis through the AMPK signaling pathway to exert anti-AS effects.</div></div><div><h3>Conclusion</h3><div>YHHR may play a role in preventing atherosclerosis by influencing the production of the intestinal flora and its associated metabolites.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100593"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509296","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the efficacy and mechanism of Qingxuan decoction in treating opioid-induced constipation","authors":"Yarong Zhang ,&nbsp;Haoshi Cao ,&nbsp;Linling Su ,&nbsp;Xianxia Yuan ,&nbsp;Ling Mo ,&nbsp;Wenyu Jiang ,&nbsp;Xiaoli Feng ,&nbsp;Dongling Liu ,&nbsp;Yang Hai","doi":"10.1016/j.prmcm.2025.100592","DOIUrl":"10.1016/j.prmcm.2025.100592","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to investigate the formulation of Qing Xuan Decoction (QXD) and its possible mechanism of action in the treatment of opioid-induced constipation (OIC).</div></div><div><h3>Methods</h3><div>We used orthogonal design experiments to optimize the decoction and ethanol precipitation process for QXD. The efficacy of QXD on loperamide - induced constipation in mice was explored via intestinal motility assay and defecation study. We examined the influence of QXD on the intestinal microbiota of mice through 16S rRNA sequencing. We assessed the alterations in the H₂O₂ and superoxide anion scavenging rates in serum using commercial kits.</div></div><div><h3>Results</h3><div>The optimal decoction protocol for QXD entails boiling it with a 10 - fold volume of water for three consecutive cycles, each lasting 1.5 h. The optimized ethanol precipitation process requires using 85 % ethanol and performing the procedure three times, with each instance of precipitation lasting over 48 h. QXD enhanced small intestine propulsion rate and defecation efficacy, significantly ameliorating loperamide-induced constipation. QXD increased the abundance of Bacteroides, Prevotella, and Akkermansia in the intestine, decreased the abundance of Desulfovibrio, and kept the intestinal flora balanced. QXD mitigated oxidative stress by decreasing H₂O₂ levels and augmenting superoxide anion scavenging ability.</div></div><div><h3>Conclusion</h3><div>QXD is expected to be a promising therapeutic drug for OIC, and its mechanism of action may be to alleviate constipation by regulating the homeostasis of intestinal flora while reducing oxidative stress.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100592"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143529134","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparative efficacy studies of nine Chinese traditional patent medicines for the treatment of post-myocardial infarction heart failure: A Bayesian network","authors":"Fuyun Jia ,&nbsp;Shengwei Gao ,&nbsp;Qiaochu Zhu ,&nbsp;Opoku Bonsu Francis ,&nbsp;Rui Liu ,&nbsp;Yadong Wang ,&nbsp;Rui Zhang ,&nbsp;Shichuan Chen ,&nbsp;Zilian Zhan ,&nbsp;Xi Zhang ,&nbsp;Qiang Xu","doi":"10.1016/j.prmcm.2025.100595","DOIUrl":"10.1016/j.prmcm.2025.100595","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Heart failure (HF) is a rapidly growing public health issue with an estimated prevalence of 64 million people globally. After many years of use and development, Traditional Chinese Medicine (TCM) has accumulated rich clinical usefulness in many diseases. This network meta-analysis aimed to assess the effectiveness of nine different Chinese traditional patent medicines (CTPMs) in the treatment of heart failure developing after acute myocardial infarction.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Determine the eligibility criteria for inclusion and exclusion in advance. Starting from literature search until September 20, 2024, conduct comprehensive data retrieval on 7 different databases. Network plots, league tables, surface-under-the-cumulative ranking (SUCRA), and funnel plots were created for each outcome. A previous registration (PROSPERO CRD42024519394) of this review protocol was undertaken.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 56 eligible RCTs involving 5,567 patients with heart failure secondary to acute myocardial infarction in which nine CTPMs were used as treatment are included. The CTPMs included &lt;em&gt;Qili Qiangxin&lt;/em&gt; capsule (QLQXC), Compound &lt;em&gt;Danshen Dripping&lt;/em&gt; Pills (CDDP), &lt;em&gt;Shexiang Baoxin&lt;/em&gt; pill (SXBXP), Stilbene &lt;em&gt;yiqi&lt;/em&gt; dropping refs (SYQDR), &lt;em&gt;Xintong&lt;/em&gt; oral liquid (XTOL), &lt;em&gt;Wenxin&lt;/em&gt; granule (WXG), &lt;em&gt;Tongxinluo&lt;/em&gt; capsule (TXLC), and &lt;em&gt;Guanxinshutong&lt;/em&gt; capsule (GXSTC) and &lt;em&gt;Huangqibaoxin&lt;/em&gt; particle (HQBXP). The experimental group received CTPM therapy in addition to conventional Western medicine (CWM) treatment, whereas the control group received just CWM treatment. The results showed that compared to those treated with CWM alone, those treated with CPTM + CWM considerably improved in all relevant measures. When evaluating clinical effectiveness based on left ventricular end-diastolic diameter and the New York Heart Association's (NYHA) cardiac functional classification, WXG + CWM was shown to be the most successful in enhancing cardiac efficiency. The 6-minute walking test results were most improved by SXBXP + CWM, but N-terminal pro-brain natriuretic peptide reduction, left ventricular ejection percent, and left ventricular end-systolic diameter were best achieved by XTOL + CWM. When compared to the other combination treatments, the QLQXC + CWM therapy was the most successful in increasing left ventricular end-diastolic volume while the GXSTC + CWM treatment was the most successful in increasing left ventricular end-systolic volume. There were no appreciable variations in safety between the groups treated with CWM alone and the ones treated with CTPMs plus CWM.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Discussion&lt;/h3&gt;&lt;div&gt;In contrast to CWM therapy alone, the combination of CTPMs and CWM treatment offers greater therapeutic benefits and is safe for treating heart failure that follows an acute myocardial infarction. For heart failure that develops after an acute myocard","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100595"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143509295","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Wuzang Wenyang Huayu Tang Treatment of vascular dementia by modulation of BCL-2/BAX/Caspase3: An integrated in vitro cellular assay and network pharmacological analysis","authors":"Yu-Cheng Lu ,&nbsp;Yu-Fu Zeng ,&nbsp;Yan-Chun Li ,&nbsp;Chun-Mei Liang ,&nbsp;Ying-Ying Cao ,&nbsp;Ling Zhang ,&nbsp;Meng-Qi Li ,&nbsp;Jia-Jia Zhong ,&nbsp;Li-Mei Liang","doi":"10.1016/j.prmcm.2025.100591","DOIUrl":"10.1016/j.prmcm.2025.100591","url":null,"abstract":"<div><h3>Objective</h3><div>This project explores Wuzang Wenyang Huayu Tang (WWHT) 's potential mechanisms for treating vascular dementia (VD) based on network pharmacology and experimental validation.</div></div><div><h3>Methods</h3><div>TCMSP was used to screen the active ingredients and targets of WWHT; GeneCards was used to identify VD-related targets; Cytoscape 3.10.0 was used to generate an \"active ingredient-target\" network map; STRING and Cytoscape were used to generate a PPI network map; Metascape and WeiShengxin performed GO and KEGG analysis to screen potential signaling pathways and explore the mechanisms; cell experiments were performed to verify the relevant targets.</div></div><div><h3>Results</h3><div>117 active components of WWHT were screened, and 146 gene targets intersected with VD. The high-frequency nodes in the PPI network include CASP3, MMP9, BCL2, etc. GO analysis showed that the biological functions involved hormones, nitrogen compounds, and other responses; KEGG analysis revealed that the pathways were concentrated in the signaling pathways such as AGE-RAGE, MAPK, etc. To treat VD, WWHT may enhance HT22 morphology in ischemia-hypoxia, control apoptosis-related proteins, and promote HT22 proliferation.</div></div><div><h3>Conclusion</h3><div>As a means to effectively treat VD, WWHT may protect neuronal cells, regulate cell apoptosis, and reduce brain damage by using a multi-component, multi-target, and multi-pathway strategy.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"15 ","pages":"Article 100591"},"PeriodicalIF":0.0,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143580698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic potential and mechanisms of puerarin in liver disease: A comprehensive review of pharmacological effects and drug delivery innovations","authors":"Lokeshvar Ravikumar ,&nbsp;Ramaiyan Velmurugan ,&nbsp;J Sam Helinto ,&nbsp;S Yokesh ,&nbsp;B Divya ,&nbsp;Harshitha GS ,&nbsp;Harish Kanna S ,&nbsp;Mahalakshmi Devaraji","doi":"10.1016/j.prmcm.2025.100594","DOIUrl":"10.1016/j.prmcm.2025.100594","url":null,"abstract":"<div><h3>Background</h3><div>Pueraria, a renowned traditional Chinese herb, has been valued for both medicinal and culinary uses. Puerarin, its primary bioactive compound, exhibits a diverse pharmacological profile and has garnered attention for its hepatoprotective properties. This review explores puerarin's potential in managing liver diseases, including hepatic malignancy, alcohol-associated liver disease, and metabolic dysfunction-associated steatotic liver disease.</div></div><div><h3>Methods</h3><div>An extensive literature review was conducted, analyzing studies that examine puerarin's effects on liver disease pathways. Emphasis was placed on its mechanisms involving lipid metabolism regulation, oxidative stress reduction, autophagy induction, and inflammation modulation. The review also evaluates novel drug delivery techniques designed to enhance puerarin's bioavailability, given its limited solubility.</div></div><div><h3>Results</h3><div>Puerarin demonstrates therapeutic efficacy across various liver diseases by targeting key biochemical pathways. Studies show it effectively modulates lipid levels, reduces oxidative stress, induces autophagy, and decreases inflammation. Recent advances in drug delivery have significantly improved puerarin's bioavailability, enhancing its clinical application potential.</div></div><div><h3>Discussion and Conclusion</h3><div>Puerarin holds promise as a safe, low-toxicity treatment for liver diseases, backed by favourable pharmacological activity and clinical trial data. Its hepatoprotective actions are further strengthened through innovative drug delivery methods, highlighting puerarin's viability in therapeutic applications. Continued research is recommended to further understand its mechanisms and optimize delivery strategies. Puerarin's unique pharmacological profile positions it as a potential therapeutic agent for liver disease management.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100594"},"PeriodicalIF":0.0,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143464574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of gut microbiota in traditional Chinese medicine processing: A general review","authors":"Rui-Rui Qiao ,&nbsp;Ya-Long Chen ,&nbsp;Ya-Ya Bai ,&nbsp;An-Dong Dong ,&nbsp;Rui Tian ,&nbsp;Ya-Jun Shi ,&nbsp;Chong-Bo Zhao ,&nbsp;Peng Zhao ,&nbsp;Jing Sun ,&nbsp;Qiao Zhang ,&nbsp;Yu-Ping Tang","doi":"10.1016/j.prmcm.2025.100590","DOIUrl":"10.1016/j.prmcm.2025.100590","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Introduction&lt;/h3&gt;&lt;div&gt;Traditional Chinese Medicine Processing (TCMP) is an integral component of Chinese medicine culture, playing a crucial role in altering the pharmacological properties of herbs, increasing their efficacy and mitigating their toxicity and adverse reactions, in order to optimize their therapeutic efficacy. Recent research has established a correlation between the gut microbiota (GM) and various physiological systems, implicating their role in disease pathogenesis. Leveraging advancements in high-throughput technologies, GM has become a prominent focus within the realm of Traditional Chinese Medicine (TCM). Notably, Chinese herbal remedies exhibit the capacity to modulate GM dysbiosis by influencing its structural and composition. Furthermore, GM actively partakes in the metabolic processing of medicinal compounds, thereby influencing their bioavailability. The application of high-throughput sequencing methodologies enables a comprehensive exploration of the intricate mechanisms through which TCM interact with the host organism via the GM, offering insights into the underlying principles governing herbal processing in Chinese medicine.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;Various scientific research articles in PubMed, Google Scholar, Web of Science and CNKI, were explored to find the research progress of GM in TCMP. A total of &gt;200 articles since 2015 were explored among which &gt;100 were shortlisted with the keywords: ‘GM’, ‘Chinese medicine’, ‘efficacy enhancing’, ‘attenuation’, ‘medicinal properties’, ‘theory of processing’. And the rest did not explain the mechanism of TCMP from the perspective of GM. The thus selected research articles were carefully read to summarize the latest and most recent developments in writing of this review.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;Our study summarizes the application progress of GM in the field of TCMP, with a focus on its role in the theory of processing and its effects on enhancing efficacy, reducing toxicity and altering medicinal properties. The results show that the TCMP could restore the structure and diversity of GM to enhance the efficacy of herbs, reduce the toxic and side effects, and change the nature of action of herbs, mainly by increasing the abundance of beneficial bacteria, reducing the abundance of pathogenic bacteria and regulating the balance of GM and short-chain fatty acids (SCFAs). This study provides a reference of methods and ideas for the research of the study of the mechanism of TCMP.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Conclusion&lt;/h3&gt;&lt;div&gt;GM has a broad application prospect in the study of the mechanism of TCMP. After the intervention in the body within processing of herbs, the structure and diversity of GM was changed, including an increase in beneficial bacteria and a decrease in pathogenic bacteria. Meanwhile, the efficacy was enhanced, the toxicity/side effects were reduced, and the properties were changed to some extent of herbs. They interact with each o","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100590"},"PeriodicalIF":0.0,"publicationDate":"2025-02-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143428614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progress of Kai-Xin-San in treating AD and depression: The possibility of \"Homotherapy for Heteropathy\"","authors":"Chang Liu ,&nbsp;Jingji Wang ,&nbsp;Guoqi Zhu","doi":"10.1016/j.prmcm.2025.100589","DOIUrl":"10.1016/j.prmcm.2025.100589","url":null,"abstract":"<div><h3>Introduction</h3><div>Alzheimer's disease (AD) and depression are two important neurological disorders with their own causes and pathogenesis. Modern research shows that AD and depression also have a series of common pathologies. Moreover, AD and depression often occur simultaneously, and depression appears in the early stages of AD and can accelerate its progression. Therefore, the common mechanism between AD and depression deserves attention. The classic famous prescription, Kai-Xin-San (KXS) could treat both of AD and depression clinically. In this study, we reviewed the efficacy of KXS against AD and depression, and proposed \"Homotherapy for Heteropathy\" in treating AD and depression based on the analysis of the mechanisms.</div></div><div><h3>Methods</h3><div>CNKI database, Web of science database and PubMed database were used to explore the therapeutic effects of KXS on AD and depression with keywords such as “Alzheimer's disease”, “AD”, “depression” and “Kai-Xin-San”, <em>etc</em>.</div></div><div><h3>Results</h3><div>This review suggests that KXS has exact effects on AD and depression and the mechanisms involve modulations of synaptic function, inflammatory response, oxidative stress, gut microbiota and hippocampal neurogenesis. According to the common mechanisms of AD and depression, and the potential treatment of KXS, we propose the \"Homotherapy for Heteropathy\" efficacy of KXS in treating AD and depression.</div></div><div><h3>Conclusions</h3><div>This review summarizes the common mechanisms between AD and depression, providing important insights for the use of KXS in treating neurological diseases.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100589"},"PeriodicalIF":0.0,"publicationDate":"2025-02-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143420287","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Traditional chinese medicine as a source of anti-diabetic agents: Investigating the potential of Leptadenia reticulata and Marsdenia tenacissima roots","authors":"Sahaya Mercy Jaquline R ,&nbsp;Neeraj Kumar ,&nbsp;Nilajan Saha ,&nbsp;Vidhu Aeri","doi":"10.1016/j.prmcm.2025.100583","DOIUrl":"10.1016/j.prmcm.2025.100583","url":null,"abstract":"<div><h3>Background</h3><div>Diabetes mellitus, a globally prevalent metabolic disorder, often requires treatments focused on glycemic control but with limited long-term efficacy and side effects. Traditional Chinese Medicine (TCM) provides a holistic alternative, addressing metabolic imbalances and preventing complications. This study explores the antidiabetic potential of <em>Leptadenia reticulata</em> (Jivanti) and <em>Marsdenia tenacissima</em> (Tong-guang-san) in a streptozotocin-induced diabetic rat model.</div></div><div><h3>Methods and Materials</h3><div>The root's ethanolic and aqueous ethanolic extracts (8:2) were prepared using a static maceration process. The α-amylase, α-glucosidase inhibition, and anti-glycation assay were performed using the extracts (50 to 300 µg/mL). Further, the extracts (100 and 200 mg/kg b.w.) were subjected to <em>in-vivo</em> anti-diabetic activity in Wistar rats with streptozotocin-induced diabetes. The oral glucose tolerance test (OGTT) was performed, and the fasting blood glucose, biochemical parameters, and lipid profile were measured. After the experimental conditions, the rats were sacrificed for pathological changes in the kidney, pancreas, and liver.</div></div><div><h3>Main Findings</h3><div>The ethanolic extract of L. <em>reticulata</em> (IC₅₀ -106.414 µg/mL) showed good inhibition of α-amylase compared to the standard acarbose (IC₅₀ -120.74 µg/mL). While ethanolic extract of M<em>. tenacissima</em> showed excellent inhibition of α-glucosidase (IC₅₀ -89.645 µg/mL), and anti-glycation activity (IC₅₀ -99.66 µg/mL) at 300 µg/mL exhibiting postprandial hypoglycemic effect. The OGTT test revealed that the ethanolic extracts of the roots of both plants at 100 and 200 mg/kg b.w dose reduced the elevated blood glucose level and restored the elevated liver parameters significantly (<em>p</em> &lt; 0.001). The group treated with ethanolic extract of L. <em>reticulata</em> and M<em>. tenacissima</em> at 100 and 200 mg/kg b.w showed amelioration of the elevated parameters of total cholesterol, triglycerides, high-density lipoproteins, and low-density lipoproteins to baseline state significantly (<em>p</em> &lt; 0.001). On the other hand, the histopathological studies showed restoration of a bunch of β-cells, which stimulated the insulin and glucose uptake by tissue, thus reducing the glucose load and increasing clearance.</div></div><div><h3>Principal Conclusion</h3><div>These investigations revealed the anti-diabetic potential of the L. <em>reticulata</em> and M<em>. tenacissima</em> root extracts, which warrants further clinical and molecular studies to make them applicable to the management of diabetes.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100583"},"PeriodicalIF":0.0,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387544","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Qingyihuaji formula prolongs overall survival time in patients with pancreatic cancer: A retrospective analysis","authors":"Libin Song ,&nbsp;Yu Zeng ,&nbsp;Chuanfang Pan ,&nbsp;Jing Xie ,&nbsp;Xiumei Zhang ,&nbsp;Jiling Feng ,&nbsp;Shengli Li","doi":"10.1016/j.prmcm.2025.100588","DOIUrl":"10.1016/j.prmcm.2025.100588","url":null,"abstract":"<div><h3>Introduction</h3><div>Pancreatic cancer (PC) is recognized for its aggressive nature and poor prognosis. Despite advancements in therapeutic approaches, the survival time for PC patients remains short. Consequently, there is a pressing need for innovative strategies to enhance outcomes and prolong the survival of individuals afflicted with PC.</div></div><div><h3>Methodology</h3><div>This study explores the impact of Qingyihuaji formula (QYHJ), a Chinese herbal medicine, on the survival duration of PC patients. We conduct a retrospective analysis of a 15-year cohort (2002–2017), comprising 2,986 PC patients who received QYHJ treatment. Patients were categorized based on the duration of QYHJ therapy: those treated for more than three months (<em>n</em> = 1,452; 48.6 %) and those treated for less than three months (<em>n</em> = 1,534; 51.4 %). Statistical methods were employed to evaluate survival outcomes, and subgroup analyses were conducted to assess the influence of clinical parameters on QYHJ's efficacy.</div></div><div><h3>Results</h3><div>Patients who underwent QYHJ treatment for over three months exhibited a significantly extended median survival time, surpassing 12 months. Additionally, the three-year survival rate increased from 1.63 % to 8.82 % in this group. Comparatively, QYHJ's protective effect was on par with surgical resection and exceeded the benefits with radiotherapy and chemotherapy. Subgroup analyses revealed that the efficacy of QYHJ was not affected by various clinical parameters, including age, gender, CA199 level, primary tumor site, metastasis status, and concurrent treatments such as radiotherapy, chemotherapy, and surgical intervention.</div></div><div><h3>Conclusion</h3><div>The retrospective analysis underscores that QYHJ treatment for a duration exceeding three months significantly enhances the survival time of PC patients, independent of major clinical characteristics. These findings suggest that QYHJ could serve as a promising adjunctive treatment for PC, with the potential to be integrated into existing therapeutic protocols. Further prospective studies are warranted to validate these results and facilitate the incorporation of QYHJ into standard PC treatment regimens.</div></div>","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100588"},"PeriodicalIF":0.0,"publicationDate":"2025-02-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143387545","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Global research trends in Chinese medicine for the treatment of non-alcoholic fatty liver disease (NAFLD): A bibliometric study","authors":"Kangjie li ,&nbsp;Jie Wang ,&nbsp;Ming Dang ,&nbsp;Runxin Ren ,&nbsp;Maomao Fu ,&nbsp;Jing Wang ,&nbsp;Qiao Zhang ,&nbsp;Chongbo Zhao","doi":"10.1016/j.prmcm.2025.100585","DOIUrl":"10.1016/j.prmcm.2025.100585","url":null,"abstract":"&lt;div&gt;&lt;h3&gt;Background&lt;/h3&gt;&lt;div&gt;The global incidence of non-alcoholic fatty liver disease (NAFLD) is rising due to changes in modern lifestyle and dietary habits, making it one of the leading causes of chronic liver disease. NAFLD can progress to more severe liver conditions, imposing significant economic burdens. Currently, no FDA-approved drugs are available for its treatment. However, Traditional Chinese Medicine (TCM) has gained attention for its unique theoretical framework and therapeutic strategies, particularly its potential to improve liver health by modulating liver function. Recent studies have also highlighted TCM's ability to regulate gut microbiota, offering a promising avenue for NAFLD management. To better understand the evolving role of TCM in treating NAFLD, a comprehensive analysis of existing research is necessary.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Methods&lt;/h3&gt;&lt;div&gt;In this study, the Web of Science database was chosen as the primary data source to investigate the treatment of non-alcoholic fatty liver disease (NAFLD) using traditional Chinese medicine (TCM). Specifically, the search focused on English articles and review articles indexed in the SCI-E and SSCI databases, spanning from January 1, 2012, to October 30, 2024. The search strategy employed the following formula: TS = (“non-alcoholic fatty liver disease” OR “Metabolic dysfunction-associated fatty liver disease” OR “NAFLD”) AND TS = (“TCM” OR “Herbal medicines”). The analysis encompassed various aspects such as authors, keywords, journals, countries, institutions, and references. For this purpose, analytical tools including VOSviewer, Bibliometrix, and CiteSpace were utilized to systematically evaluate the gathered data.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Results&lt;/h3&gt;&lt;div&gt;A total of 306 documents were retrieved, indicating a rising trend in the number of publications, which is expected to accelerate in the future. China is at the forefront in terms of both the quantity of publications and total citations, demonstrating strong international collaboration. Within China, Shanghai University of TCM and Chengdu University of TCM are leading institutions, having established a stable group of collaborating authors. The top 10 key journals account for 49.02 % of the publications, with Frontiers in Pharmacology being the most prolific, while the World Journal of Gastroenterology boasts the highest average number of citations. The most frequently cited journals are Hepatology, Journal of Hepatology, and Journal of Ethnopharmacology. Keyword analysis reveals that high-frequency terms such as steatohepatitis are prevalent, addressing topics like pathogenesis, indirect therapeutic effects, and molecular biological mechanisms. Recent outbreak word analysis highlights 'cell' and 'steatohepatitis' as current hotspots, with 'NASH' anticipated to be a focal point in 2024.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;h3&gt;Discussion&lt;/h3&gt;&lt;div&gt;The number of publications on TCM treatments for NAFLD has steadily increased, with TCM exhibiting therapeut","PeriodicalId":101013,"journal":{"name":"Pharmacological Research - Modern Chinese Medicine","volume":"14 ","pages":"Article 100585"},"PeriodicalIF":0.0,"publicationDate":"2025-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143224975","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}